Kuo-Hsing Lee - Related publications

Affiliations: 
University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Pharmaceutical Chemistry, Oncology
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Sherbiny FF, Bayoumi AH, El-Morsy AM, Sobhy M, Hagras M. Design, Synthesis, biological Evaluation, and molecular docking studies of novel Pyrazolo[3,4-d]Pyrimidine derivative scaffolds as potent EGFR inhibitors and cell apoptosis inducers. Bioorganic Chemistry. 116: 105325. PMID 34507234 DOI: 10.1016/j.bioorg.2021.105325   
2021 Aliwaini S, Abu Thaher B, Al-Masri I, Shurrab N, El-Kurdi S, Schollmeyer D, Qeshta B, Ghunaim M, Csuk R, Laufer S, Kaiser L, Deigner HP. Design, Synthesis and Biological Evaluation of Novel Pyrazolo[1,2,4]triazolopyrimidine Derivatives as Potential Anticancer Agents. Molecules (Basel, Switzerland). 26. PMID 34279406 DOI: 10.3390/molecules26134065   
2021 Abebe FA, Hopkins MD, Vodnala SN, Sheaff RJ, Lamar AA. Development of a Rapid Screening Assay Using Metabolic Inhibitors to Detect Highly Selective Anticancer Agents. Acs Omega. 6: 18333-18343. PMID 34308064 DOI: 10.1021/acsomega.1c02203   
2021 Abebe FA, Hopkins MD, Vodnala SN, Sheaff RJ, Lamar AA. Development of a Rapid Screening Assay Using Metabolic Inhibitors to Detect Highly Selective Anticancer Agents. Acs Omega. 6: 18333-18343. PMID 34308064 DOI: 10.1021/acsomega.1c02203   
2021 Yang BJ, Wang J, Zeng ZQ, Yang X, Huang AY, Hao XJ, Ding X, Li SL. Sesquiterpene lactones from L. and their activity in inducing protective autophagy. Natural Product Research. 1-4. PMID 34498970 DOI: 10.1080/14786419.2021.1955881   
2021 Zhu PJ, Yu ZZ, Lv YF, Zhao JL, Tong YY, You QD, Jiang ZY. Discovery of 3,5-Dimethyl-4-Sulfonyl-1-Pyrrole-Based Myeloid Cell Leukemia 1 Inhibitors with High Affinity, Selectivity, and Oral Bioavailability. Journal of Medicinal Chemistry. PMID 34342996 DOI: 10.1021/acs.jmedchem.1c00682   
2021 Laamari Y, Oubella A, Bimoussa A, El Mansouri AE, Ketatni EM, Mentre O, Ait Itto MY, Morjani H, Khouili M, Auhmani A. Design, Hemiysnthesis, crystal structure and anticancer activity of 1, 2, 3-triazoles derivatives of totarol. Bioorganic Chemistry. 115: 105165. PMID 34298240 DOI: 10.1016/j.bioorg.2021.105165   
2021 Liang Y, Zhang M, Zhou P, Liu M, Li J, Wang Y. Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitors. Bioorganic Chemistry. 115: 105239. PMID 34399321 DOI: 10.1016/j.bioorg.2021.105239   
2021 Giang VH, Thuy LT, Cham PT, Vinh LB, Ban NK, Linh TM, Mai NC, Hoe PT, Huong TT, Dang NH, Oh H, Quang TH. Chemical constituents from and their anti-inflammatory and cytotoxic activities. Natural Product Research. 1-7. PMID 34498971 DOI: 10.1080/14786419.2021.1958807   
2021 Yaylı N, Kılıç G, Kahriman N, Kanbolat Ş, Bozdeveci A, Alpay Karaoğlu Ş, Aliyazıcıoğlu R, Erdinç Sellitepe H, Selin Doğan İ, Aydın A, Tatar G. Synthesis, biological evaluation (antioxidant, antimicrobial, enzyme inhibition, and cytotoxic) and molecular docking study of hydroxy methoxy benzoin/benzil analogous. Bioorganic Chemistry. 115: 105183. PMID 34339978 DOI: 10.1016/j.bioorg.2021.105183   
2021 Sun J, Wang J, Wang X, Hu X, Cao H, Bai J, Li D, Hua H. Design and synthesis of β-carboline derivatives with nitrogen mustard moieties against breast cancer. Bioorganic & Medicinal Chemistry. 45: 116341. PMID 34365102 DOI: 10.1016/j.bmc.2021.116341   
2021 Sisodiya S, Paul S, Chaudhary H, Grewal P, Kumar G, Daniel DP, Das B, Nayak D, Guchhait SK, Kundu CN, Banerjee UC. Exploration of Benzo[b]carbazole-6,11-diones as anticancer agents: Synthesis and studies of hTopoIIα inhibition and Apoptotic effects. Bioorganic & Medicinal Chemistry Letters. 128274. PMID 34303812 DOI: 10.1016/j.bmcl.2021.128274   
2021 Sisodiya S, Paul S, Chaudhary H, Grewal P, Kumar G, Daniel DP, Das B, Nayak D, Guchhait SK, Kundu CN, Banerjee UC. Exploration of Benzo[b]carbazole-6,11-diones as anticancer agents: Synthesis and studies of hTopoIIα inhibition and Apoptotic effects. Bioorganic & Medicinal Chemistry Letters. 128274. PMID 34303812 DOI: 10.1016/j.bmcl.2021.128274   
2021 Vézina-Dawod S, Perreault M, Guay LD, Gerber N, Gobeil S, Biron E. Synthesis and biological evaluation of novel 1,4-benzodiazepin-3-one derivatives as potential antitumor agents against prostate cancer. Bioorganic & Medicinal Chemistry. 45: 116314. PMID 34333393 DOI: 10.1016/j.bmc.2021.116314   
2021 Zheng Q, Xu XB, Jin H, Zhang W, Rao GW. Synthesis and anti-proliferation activity evaluation of novel 2-chloroquinazoline as potential EGFR-TK inhibitors. Chemistry & Biodiversity. PMID 34510749 DOI: 10.1002/cbdv.202100478   
2021 Arshad N, Yaseen M, Hashim J, Ullah I, Khan R, Safi I, Rafique A, Hanif QU, Kulsoom UA. Antiproliferative activity of 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine thione (THTT) derivatives and evaluation as potential prodrug. Pakistan Journal of Pharmaceutical Sciences. 34: 773-779. PMID 34275814   
2021 Elhady SS, Abdelhameed RFA, Zekry SH, Ibrahim AK, Habib ES, Darwish KM, Hazem RM, Mohammad KA, Hassanean HA, Ahmed SA. VEGFR-Mediated Cytotoxic Activity of Isolated Metabolites: A Biological Evaluation and In Silico Study. Life (Basel, Switzerland). 11. PMID 34440504 DOI: 10.3390/life11080759   
2021 El Azab IH, Saied EM, Osman AA, Mehana AE, Saad HA, Elkanzi NA. Novel -bridged pyrazole-1-carbothioamides with potential antiproliferative activity: design, synthesis, and studies. Future Medicinal Chemistry. PMID 34427113 DOI: 10.4155/fmc-2021-0066   
2021 Yang H, Li Q, Su M, Luo F, Liu Y, Wang D, Fan Y. Design, synthesis, and biological evaluation of novel 6-(pyridin-3-yl) quinazolin-4(3H)-one derivatives as potential anticancer agents via PI3K inhibition. Bioorganic & Medicinal Chemistry. 46: 116346. PMID 34403956 DOI: 10.1016/j.bmc.2021.116346   
2021 Wang R, Li Y, Hu H, Persoons L, Daelemans D, De Jonghe S, Luyten W, Krasniqi B, Dehaen W. Antibacterial and antitumoral properties of 1,2,3-triazolo fused triterpenes and their mechanism of inhibiting the proliferation of HL-60 cells. European Journal of Medicinal Chemistry. 224: 113727. PMID 34352711 DOI: 10.1016/j.ejmech.2021.113727   
2021 Gade IS, Chadeneau C, Richard TS, Atchade AT, Talla E, Seite P, Vannier B, Guillard J, Laurent S, Henoumont C, Nwabo AHK, Muller JM. A new flavonoid glycoside from (Loranthaceae) and evaluation of anticancer activity of extract and some isolated compounds. Natural Product Research. 1-9. PMID 34380347 DOI: 10.1080/14786419.2021.1963243   
2021 Grigolo TA, Braga CB, Ornelas C, Russowsky D, Ferreira-Silva GA, Ionta M, Pilli RA. Hybrids of 4-hydroxy derivatives of goniothalamin and piplartine bearing a diester or a 1,2,3-triazole linker as antiproliferative agents. Bioorganic Chemistry. 116: 105292. PMID 34509797 DOI: 10.1016/j.bioorg.2021.105292   
2021 Soliman AM, Khalil A, Ramadan E, Ghorab MM. Induction of apoptosis, cytotoxicity and radiosensitization by novel 3,4-dihydroquinazolinone derivatives. Bioorganic & Medicinal Chemistry Letters. 128308. PMID 34363937 DOI: 10.1016/j.bmcl.2021.128308   
2021 Unadkat V, Rohit S, Parikh P, Sanna V, Singh S. Rational design-aided discovery of novel 1,2,4-oxadiazole derivatives as potential EGFR inhibitors. Bioorganic Chemistry. 114: 105124. PMID 34328857 DOI: 10.1016/j.bioorg.2021.105124   
2021 Dawood KM, Raslan MA, Abbas AA, Mohamed BE, Abdellattif MH, Nafie MS, Hassan MK. Novel -Thiazole Derivatives: Synthesis and Potential Cytotoxic Activity Through Apoptosis With Molecular Docking Approaches. Frontiers in Chemistry. 9: 694870. PMID 34458233 DOI: 10.3389/fchem.2021.694870   
2021 Prakash P, Kumari N, Gayathiri E, Selvam K, Ragunathan MG, Chandrasekaran M, Al-Dosary MA, Hatamleh AA, Nadda AK, Kumar M. In Vitro and In Silico Toxicological Properties of Natural Antioxidant Therapeutic Agent . LAM. Antioxidants (Basel, Switzerland). 10. PMID 34439555 DOI: 10.3390/antiox10081307   
2021 Han X, Song N, Saidahmatov A, Wang P, Wang Y, Hu X, Kan W, Zhu W, Gao L, Zeng M, Wang Y, Li C, Li J, Liu H, Zhou Y, et al. Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia. Journal of Medicinal Chemistry. PMID 34477384 DOI: 10.1021/acs.jmedchem.1c01148   
2021 Patel PA, Bruun T, Ilina P, Mäkkylä H, Lempinen A, Yli-Kauhaluoma J, Tammela P, Kiuru PS. Synthesis and Cytotoxicity Evaluation of Spirocyclic Bromotyrosine Clavatadine C Analogs. Marine Drugs. 19. PMID 34356825 DOI: 10.3390/md19070400   
2021 Liu L, Wang Z, Gao C, Dai H, Si X, Zhang Y, Meng Y, Zheng J, Ke Y, Liu H, Zhang Q. Design, synthesis and antitumor activity evaluation of trifluoromethyl-substituted pyrimidine derivatives. Bioorganic & Medicinal Chemistry Letters. 128268. PMID 34302974 DOI: 10.1016/j.bmcl.2021.128268   
2021 Liu L, Wang Z, Gao C, Dai H, Si X, Zhang Y, Meng Y, Zheng J, Ke Y, Liu H, Zhang Q. Design, synthesis and antitumor activity evaluation of trifluoromethyl-substituted pyrimidine derivatives. Bioorganic & Medicinal Chemistry Letters. 128268. PMID 34302974 DOI: 10.1016/j.bmcl.2021.128268   
2021 Sim S, Lee S, Ko S, Phuong Bui B, Linh Nguyen P, Cho J, Lee K, Kang JS, Jung JK, Lee H. Design, synthesis, and biological evaluation of potent 1,2,3,4-tetrahydroisoquinoline derivatives as anticancer agents targeting NF-κB signaling pathway. Bioorganic & Medicinal Chemistry. 46: 116371. PMID 34500188 DOI: 10.1016/j.bmc.2021.116371   
2021 Wang G, Liu W, Fan M, He M, Li Y, Peng Z. Design, synthesis and biological evaluation of novel thiazole-naphthalene derivatives as potential anticancer agents and tubulin polymerisation inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 36: 1694-1702. PMID 34309466 DOI: 10.1080/14756366.2021.1958213   
2021 Parmar DR, Soni JY, Guduru R, Rayani RH, Kusurkar RV, Vala AG, Talukdar SN, Eissa IH, Metwaly AM, Khalil A, Zunjar V, Battula S. Discovery of new anticancer thiourea-azetidine hybrids: design, synthesis, in vitro antiproliferative, SAR, in silico molecular docking against VEGFR-2, ADMET, toxicity, and DFT studies. Bioorganic Chemistry. 115: 105206. PMID 34339975 DOI: 10.1016/j.bioorg.2021.105206   
2021 Wang S, Wang X, Shao Y, Shao K, Wang Y, Guo X, Dong H, Zhao W, Li Y, Li G. Synthesis and evaluation of 3-(phenylethynyl)-1,1'-biphenyl-2-carboxylate derivatives as new HIF-1 inhibitors. Bioorganic Chemistry. 116: 105298. PMID 34454298 DOI: 10.1016/j.bioorg.2021.105298   
2021 Ali A, Ali A, Tahir A, Bakht MA, Salahuddin, Ahsan MJ. Molecular Engineering of Curcumin, an Active Constituent of L. (Turmeric) of the Family with Improved Antiproliferative Activity. Plants (Basel, Switzerland). 10. PMID 34451604 DOI: 10.3390/plants10081559   
2021 Gomes AR, Pires AS, Abrantes AM, Gonçalves AC, Costa SC, Varela CL, Silva ET, Botelho MF, Roleira FMF. Design, synthesis, and antitumor activity evaluation of steroidal oximes. Bioorganic & Medicinal Chemistry. 46: 116360. PMID 34425478 DOI: 10.1016/j.bmc.2021.116360   
2021 Zhou B, Gao XH, Zhang MM, Zheng CY, Liu HC, Yue JM. Discovery of four modified classes of triterpenoids delineated a metabolic cascade: compound characterization and biomimetic synthesis. Chemical Science. 12: 9831-9838. PMID 34349957 DOI: 10.1039/d1sc02710g   
2021 Hayat K, Tariq U, Wong QA, Quah CK, Majid ASA, Nazari V M, Ahamed MBK, Iqbal MA, Tirmizi SA. Green synthesis of selenium based N-heterocyclic carbene compounds; structural, in-vitro anticancer and molecular docking studies. Computational Biology and Chemistry. 94: 107567. PMID 34500323 DOI: 10.1016/j.compbiolchem.2021.107567   
2021 Delbart DI, Giri GF, Cammarata A, Bareño LA, Amigo NL, Bechis A, Suarez AG, Spanevello RÁ, Todaro LB, Urtreger AJ. Antineoplastic activity of products derived from cellulose-containing materials: levoglucosenone and structurally-related derivatives as new alternatives for breast cancer treatment. Investigational New Drugs. PMID 34478029 DOI: 10.1007/s10637-021-01167-6   
2021 Niu JB, Hua CQ, Liu Y, Yu GX, Yang JJ, Li YR, Zhang YB, Qi YQ, Song J, Jin CY, Zhang SY. Discovery of -aryl sulphonamide-quinazoline derivatives as anti-gastric cancer agents and activating the Hippo signalling pathway. Journal of Enzyme Inhibition and Medicinal Chemistry. 36: 1715-1731. PMID 34425716 DOI: 10.1080/14756366.2021.1958211   
2021 Oliveira AR, Dos Santos FA, Ferreira LPL, Pitta MGDR, Silva MVO, Cardoso MVO, Pinto AF, Marchand P, de Melo Rêgo MJB, Leite ACL. Synthesis, anticancer activity and mechanism of action of new phthalimido-1,3-thiazoles derivatives. Chemico-Biological Interactions. 109597. PMID 34303695 DOI: 10.1016/j.cbi.2021.109597   
2021 Akkol EK, Tatlı II, Karatoprak GŞ, Ağar OT, Yücel Ç, Sobarzo-Sánchez E, Capasso R. Is Emodin with Anticancer Effects Completely Innocent? Two Sides of the Coin. Cancers. 13. PMID 34073059 DOI: 10.3390/cancers13112733   
2021 Hafez DE, Hafez E, Eddiasty I, Shih SP, Chien LC, Hong YJ, Lin HY, Keeton AB, Piazza GA, Abdel-Halim M, Abadi AH. Novel thiazolidine derivatives as potent selective pro-apoptotic agents. Bioorganic Chemistry. 114: 105143. PMID 34328854 DOI: 10.1016/j.bioorg.2021.105143   
2021 Xu T, Tian W, Zhang Q, Liu J, Liu Z, Jin J, Guo Y, Bai LP. Novel 1,3,4-thiadiazole/oxadiazole-linked honokiol derivatives suppress cancer via inducing PI3K/Akt/mTOR-dependent autophagy. Bioorganic Chemistry. 115: 105257. PMID 34426156 DOI: 10.1016/j.bioorg.2021.105257   
2021 Kardile RA, Sarkate AP, Borude AS, Mane RS, Lokwani DK, Tiwari SV, Azad R, Burra PVLS, Thopate SR. Design and synthesis of novel conformationally constrained 7,12-dihydrodibenzo[b,h][1,6] naphthyridine and 7H-Chromeno[3,2-c] quinoline derivatives as topoisomerase I inhibitors: In vitro screening, molecular docking and ADME predictions. Bioorganic Chemistry. 115: 105174. PMID 34314913 DOI: 10.1016/j.bioorg.2021.105174   
2021 Chen XH, Zhao YY, Wang Q, Li ZL, Li FX, Tan HY, Huang YY. Chemical constituents from the stems of with their cytotoxic activities. Journal of Asian Natural Products Research. 1-6. PMID 34308726 DOI: 10.1080/10286020.2021.1951713   
2021 Yuan P, Gu X, Ni X, Qi Y, Shao X, Xu X, Liu J, Qian X. Non-alkylator anti-glioblastoma agents induced cell cycle G2/M arrest and apoptosis:Design, In silico physicochemical and SAR Studies of 2-Aminoquinoline-3-carboxamides. Bioorganic & Medicinal Chemistry Letters. 128371. PMID 34534673 DOI: 10.1016/j.bmcl.2021.128371   
2021 Zagórska A, Czopek A, Jaromin A, Mielczarek-Puta M, Struga M, Stary D, Bajda M. Design, Synthesis, and In Vitro Antiproliferative Activity of Hydantoin and Purine Derivatives with the 4-Acetylphenylpiperazinylalkyl Moiety. Materials (Basel, Switzerland). 14. PMID 34361351 DOI: 10.3390/ma14154156   
2021 Islam MK, Baek AR, Sung B, Yang BW, Choi G, Park HJ, Kim YH, Kim M, Ha S, Lee GH, Kim HK, Chang Y. Synthesis, Characterization, and Anticancer Activity of Benzothiazole Aniline Derivatives and Their Platinum (II) Complexes as New Chemotherapy Agents. Pharmaceuticals (Basel, Switzerland). 14. PMID 34451928 DOI: 10.3390/ph14080832   
2021 Khalil NA, Ahmed EM, Zaher AF, Sobh EA, El-Sebaey SA, El-Zoghbi MS. New benzothieno[2,3-]pyridines as non-steroidal CYP17 inhibitors: design, synthesis, anticancer screening, apoptosis induction, and ADME profile studies. Journal of Enzyme Inhibition and Medicinal Chemistry. 36: 1839-1859. PMID 34338119 DOI: 10.1080/14756366.2021.1958212