Alex Kentsis, MD, PhD - Publications

Affiliations: 
Memorial Sloan-Kettering Cancer Center, Rockville Centre, NY, United States 
Area:
Cancer biology, rational therapy, drug design
Website:
http://alexkentsis.net

52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Ramaswamy K, Forbes L, Minuesa G, Gindin T, Brown F, Kharas MG, Krivtsov AV, Armstrong SA, Still E, de Stanchina E, Knoechel B, Koche R, Kentsis A. Peptidomimetic blockade of MYB in acute myeloid leukemia. Nature Communications. 9: 110. PMID 29317678 DOI: 10.1038/s41467-017-02618-6  0.76
2016 Ortiz MV, Kobos R, Walsh M, Slotkin EK, Roberts S, Berger MF, Hameed M, Solit D, Ladanyi M, Shukla N, Kentsis A. Integrating Genomics Into Clinical Pediatric Oncology Using the Molecular Tumor Board at the Memorial Sloan Kettering Cancer Center. Pediatric Blood & Cancer. PMID 27082517 DOI: 10.1002/pbc.26002  1
2016 Rosenfeld JA, Reeves D, Brugler MR, Narechania A, Simon S, Durrett R, Foox J, Shianna K, Schatz MC, Gandara J, Afshinnekoo E, Lam ET, Hastie AR, Chan S, Cao H, ... ... Kentsis A, et al. Genome assembly and geospatial phylogenomics of the bed bug Cimex lectularius. Nature Communications. 7: 10164. PMID 26836631 DOI: 10.1038/ncomms10164  1
2015 Sabath DE, Bender MA, Sankaran VG, Vamos E, Kentsis A, Yi HS, Greisman HA. Characterization of Deletions of the HBA and HBB Loci by Array Comparative Genomic Hybridization. The Journal of Molecular Diagnostics : Jmd. PMID 26612711 DOI: 10.1016/j.jmoldx.2015.07.011  1
2015 Laszlo GS, Alonzo TA, Gudgeon CJ, Harrington KH, Kentsis A, Gerbing RB, Wang YC, Ries RE, Raimondi SC, Hirsch BA, Gamis AS, Meshinchi S, Walter RB. High expression of myocyte enhancer factor 2C (MEF2C) is associated with adverse-risk features and poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group. Journal of Hematology & Oncology. 8: 115. PMID 26487643 DOI: 10.1186/s13045-015-0215-4  1
2015 Muntel J, Xuan Y, Berger ST, Reiter L, Bachur R, Kentsis A, Steen H. Advancing Urinary Protein Biomarker Discovery by Data-independent Acquisition on a Quadrupole-Orbitrap Mass Spectrometer. Journal of Proteome Research. PMID 26423119 DOI: 10.1021/acs.jproteome.5b00826  1
2015 Henssen AG, Henaff E, Jiang E, Eisenberg AR, Carson JR, Villasante CM, Ray M, Still E, Burns M, Gandara J, Feschotte C, Mason CE, Kentsis A. Genomic DNA transposition induced by human PGBD5. Elife. 4. PMID 26406119 DOI: 10.7554/eLife.10565  1
2015 Berger ST, Ahmed S, Muntel J, Cuevas Polo N, Bachur R, Kentsis A, Steen J, Steen H. MStern blotting - high throughput PVDF membrane-based proteomic sample preparation for 96-well plates. Molecular & Cellular Proteomics : McP. PMID 26223766 DOI: 10.1074/mcp.O115.049650  1
2015 Etchin J, Montero J, Berezovskaya A, Le BT, Kentsis A, Christie AL, Conway AS, Chen WC, Reed C, Mansour MR, Ng CE, Adamia S, Rodig SJ, Galinsky IA, Stone RM, et al. Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-Initiating cells engrafted into immunosuppressed NSG mice. Leukemia. PMID 26202935 DOI: 10.1038/leu.2015.194  1
2015 Dhabaria A, Cifani P, Reed C, Steen H, Kentsis A. A high-efficiency cellular extraction system for biological proteomics. Journal of Proteome Research. PMID 26153614 DOI: 10.1021/acs.jproteome.5b00547  1
2015 McGee SF, Kornblau SM, Qiu Y, Look AT, Zhang N, Yoo SY, Coombes KR, Kentsis A. Biological properties of ligand-dependent activation of the MET receptor kinase in acute myeloid leukemia. Leukemia. 29: 1218-21. PMID 25541150 DOI: 10.1038/leu.2014.348  1
2015 Mansour MR, Reed C, Eisenberg AR, Tseng JC, Twizere JC, Daakour S, Yoda A, Rodig SJ, Tal N, Shochat C, Berezovskaya A, DeAngelo DJ, Sallan SE, Weinstock DM, Izraeli S, ... ... Kentsis A, et al. Targeting oncogenic interleukin-7 receptor signalling with N-acetylcysteine in T cell acute lymphoblastic leukaemia. British Journal of Haematology. 168: 230-8. PMID 25256574 DOI: 10.1111/bjh.13115  1
2015 Ramaswamy K, Spitzer B, Kentsis A. Therapeutic re-activation of protein phosphatase 2A in acute myeloid leukemia Frontiers in Oncology. 5. DOI: 10.3389/fonc.2015.00016  1
2014 Gutierrez A, Pan L, Groen RWJ, Baleydier F, Kentsis A, Marineau J, Grebliunaite R, Kozakewich E, Reed C, Pflumio F, Poglio S, Uzan B, Clemons P, VerPlank L, An F, et al. Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia Journal of Clinical Investigation. 124: 644-655. PMID 24401270 DOI: 10.1172/JCI65093  1
2013 Abdolvahabi A, Taylor BW, Holden RL, Shaw EV, Kentsis A, Rodriguez-Galindo C, Mukai S, Shaw BF. Colorimetric and longitudinal analysis of leukocoria in recreational photographs of children with retinoblastoma. Plos One. 8: e76677. PMID 24204654 DOI: 10.1371/journal.pone.0076677  1
2013 Etchin J, Sanda T, Mansour MR, Kentsis A, Montero J, Le BT, Christie AL, McCauley D, Rodig SJ, Kauffman M, Shacham S, Stone R, Letai A, Kung AL, Thomas Look A. KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. British Journal of Haematology. 161: 117-27. PMID 23373539 DOI: 10.1111/bjh.12231  1
2013 Kentsis A, Shulman A, Ahmed S, Brennan E, Monuteaux MC, Lee YH, Lipsett S, Paulo JA, Dedeoglu F, Fuhlbrigge R, Bachur R, Bradwin G, Arditi M, Sundel RP, Newburger JW, et al. Urine proteomics for discovery of improved diagnostic markers of Kawasaki disease Embo Molecular Medicine. 5: 210-220. PMID 23281308 DOI: 10.1002/emmm.201201494  1
2013 Etchin J, Sun Q, Kentsis A, Farmer A, Zhang ZC, Sanda T, Mansour MR, Barcelo C, McCauley D, Kauffman M, Shacham S, Christie AL, Kung AL, Rodig SJ, Chook YM, et al. Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia. 27: 66-74. PMID 22847027 DOI: 10.1038/leu.2012.219  1
2012 Kentsis A, Reed C, Rice KL, Sanda T, Rodig SJ, Tholouli E, Christie A, Valk PJ, Delwel R, Ngo V, Kutok JL, Dahlberg SE, Moreau LA, Byers RJ, Christensen JG, et al. Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia. Nature Medicine. 18: 1118-22. PMID 22683780 DOI: 10.1038/nm.2819  1
2012 Kentsis A, Ahmed S, Kurek K, Brennan E, Bradwin G, Steen H, Bachur R. Detection and diagnostic value of urine leucine-rich α-2-glycoprotein in children with suspected acute appendicitis Annals of Emergency Medicine. 60: 78-83. PMID 22305331 DOI: 10.1016/j.annemergmed.2011.12.015  1
2012 Kentsis A, Look AT. Distinct and dynamic requirements for mTOR signaling in hematopoiesis and leukemogenesis Cell Stem Cell. 11: 281-282. DOI: 10.1016/j.stem.2012.08.007  1
2011 Gutierrez A, Kentsis A, Sanda T, Holmfeldt L, Chen SC, Zhang J, Protopopov A, Chin L, Dahlberg SE, Neuberg DS, Silverman LB, Winter SS, Hunger SP, Sallan SE, Zha S, et al. The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. Blood. 118: 4169-73. PMID 21878675 DOI: 10.1182/blood-2010-11-318873  1
2011 Kentsis A. Challenges and opportunities for discovery of disease biomarkers using urine proteomics Pediatrics International. 53: 1-6. PMID 20840485 DOI: 10.1111/j.1442-200X.2010.03253.x  1
2010 Kentsis A, Lin YY, Kurek K, Calicchio M, Wang YY, Monigatti F, Campagne F, Lee R, Horwitz B, Steen H, Bachur R. Discovery and validation of urine markers of acute pediatric appendicitis using high-accuracy mass spectrometry. Annals of Emergency Medicine. 55: 62-70.e4. PMID 19556024 DOI: 10.1016/j.annemergmed.2009.04.020  1
2009 Kentsis A, Bradwin G, Miller DT, Trenor CC. Venous thrombosis associated with gene deletion of tissue factor pathway inhibitor. American Journal of Hematology. 84: 775-6. PMID 19806663 DOI: 10.1002/ajh.21542  1
2009 Kentsis A, Anewalt R, Ganguly A, Allen JB, Neufeld EJ. Discordant haemophilia A in male siblings due to a de novo mutation on a familial missense mutant allele. Haemophilia : the Official Journal of the World Federation of Hemophilia. 15: 971-2. PMID 19456877 DOI: 10.1111/j.1365-2516.2009.02035.x  1
2009 Kentsis A, Monigatti F, Dorff K, Campagne F, Bachur R, Steen H. Urine proteomics for profiling of human disease using high accuracy mass spectrometry Proteomics - Clinical Applications. 3: 1052-1061. DOI: 10.1002/prca.200900008  1
2007 Kentsis A, Gindin T, Mezei M, Osman R. Calculation of the free energy and cooperativity of protein folding Plos One. 2. PMID 17505540 DOI: 10.1371/journal.pone.0000446  1
2007 Poyurovsky MV, Priest C, Kentsis A, Borden KLB, Pan ZQ, Pavletich N, Prives C. The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity Embo Journal. 26: 90-101. PMID 17170710 DOI: 10.1038/sj.emboj.7601465  1
2006 Kentsis A. Correspondence patterns: mechanisms and models of human dynamics. Nature.. 441: E5; discussion E5-6. PMID 16724015  1
2006 Kentsis A. Mechanisms and models of human dynamics Nature. 441: E5. DOI: 10.1038/nature04901  1
2005 Kentsis A, Volpon L, Topisirovic I, Soll CE, Culjkovic B, Shao L, Borden KLB. Further evidence that ribavirin interacts with eIF4E Rna. 11: 1762-1766. PMID 16251386 DOI: 10.1261/rna.2238705  1
2005 Kentsis A, Mezei M, Osman R. Origin of the sequence-dependent polyproline II structure in unfolded peptides Proteins: Structure, Function and Genetics. 61: 769-776. PMID 16193481 DOI: 10.1002/prot.20655  1
2005 Ulane CM, Kentsis A, Cruz CD, Parisien JP, Schneider KL, Horvath CM. Composition and assembly of STAT-targeting ubiquitin ligase complexes: paramyxovirus V protein carboxyl terminus is an oligomerization domain. Journal of Virology. 79: 10180-9. PMID 16051811 DOI: 10.1128/JVI.79.16.10180-10189.2005  1
2005 Topisirovic I, Kentsis A, Perez JM, Guzman ML, Jordan CT, Borden KL. Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels. Molecular and Cellular Biology. 25: 1100-12. PMID 15657436 DOI: 10.1128/MCB.25.3.1100-1112.2005  1
2005 Miller F, Kentsis A, Osman R, Pan ZQ. Inactivation of VHL by tumorigenic mutations that disrupt dynamic coupling of the pVHL·hypoxia-inducible transcription factor-1α complex Journal of Biological Chemistry. 280: 7985-7996. PMID 15611064 DOI: 10.1074/jbc.M413160200  1
2004 Kentsis A, Topisirovic I, Culjkovic B, Shao L, Borden KLB. Ribavirin suppresses elF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap Proceedings of the National Academy of Sciences of the United States of America. 101: 18105-18110. PMID 15601771 DOI: 10.1073/pnas.0406927102  1
2004 Kentsis A, Mezei M, Gindin T, Osman R. Unfolded State of Polyalanine Is a Segmented Polyproline II Helix Proteins: Structure, Function and Genetics. 55: 493-501. PMID 15103613 DOI: 10.1002/prot.20051  1
2004 Kentsis A, Borden KLB. Physical mechanisms and biological significance of supramolecular protein self-assembly Current Protein and Peptide Science. 5: 125-134. PMID 15078223 DOI: 10.2174/1389203043486856  1
2004 Pan ZQ, Kentsis A, Dias DC, Yamoah K, Wu K. Nedd8 on cullin: Building an expressway to protein destruction Oncogene. 23: 1985-1997. PMID 15021886 DOI: 10.1038/sj.onc.1207414  1
2003 Kentsis A, Mezei M, Osman R. MC-PHS: A Monte Carlo implementation of the primary hydration shell for protein folding and design Biophysical Journal. 84: 805-815. PMID 12547765  1
2002 Kentsis A, Gordon RE, Borden KLB. Control of biochemical reactions through supramolecular RING domain self-assembly Proceedings of the National Academy of Sciences of the United States of America. 99: 15404-15409. PMID 12438698 DOI: 10.1073/pnas.202608799  1
2002 Kentsis A, Gordon RE, Borden KLB. Self-assembly properties of a model RING domain Proceedings of the National Academy of Sciences of the United States of America. 99: 667-672. PMID 11792829 DOI: 10.1073/pnas.012317299  1
2001 Kentsis A, Dwyer EC, Perez JM, Sharma M, Chen A, Pan ZQ, Borden KLB. The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E Journal of Molecular Biology. 312: 609-623. PMID 11575918 DOI: 10.1006/jmbi.2001.5003  1
2001 Cohen N, Sharma M, Kentsis A, Perez JM, Strudwick S, Borden KLB. PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA Embo Journal. 20: 4547-4559. PMID 11500381 DOI: 10.1093/emboj/20.16.4547  1
2000 Kentsis A, Borden KLB. Construction of Macromolecular Assemblages in Eukaryotic Processes and their Role in Human Disease: Linking RINGs Together Current Protein and Peptide Science. 1: 49-73. PMID 12369920  1
2000 Krantz BA, Moran LB, Kentsis A, Sosnick TR. D/H amide kinetic isotope effects reveal when hydrogen bonds form during protein folding. Nature Structural Biology. 7: 62-71. PMID 10625430 DOI: 10.1038/71265  1
2000 Kentsis A, Sharma M, Ferez JM, Borden KLB. Reconstructing the pml nuclear body: pml binds eif4e and lowers its affinity for 5' cap of mrna Blood. 96: 91a.  1
1999 Moran LB, Schneider JP, Kentsis A, Reddy GA, Sosnick TR. Transition state heterogeneity in GCN4 coiled coil folding studied by using multisite mutations and crosslinking. Proceedings of the National Academy of Sciences of the United States of America. 96: 10699-704. PMID 10485889 DOI: 10.1073/pnas.96.19.10699  1
1999 Rosenfield RL, Kentsis A, Deplewski D, Ciletti N. Rat preputial sebocyte differentiation involves peroxisome proliferator- activated receptors Journal of Investigative Dermatology. 112: 226-232. PMID 9989800 DOI: 10.1046/j.1523-1747.1999.00487.x  1
1998 Kentsis A, Sosnick TR. Trifluoroethanol promotes helix formation by destabilizing backbone exposure: desolvation rather than native hydrogen bonding defines the kinetic pathway of dimeric coiled coil folding. Biochemistry. 37: 14613-22. PMID 9772190 DOI: 10.1021/bi981641y  1
1998 Rosenfield RL, Deplewski D, Kentsis A, Ciletti N. Mechanisms of androgen induction of sebocyte differentiation Dermatology. 196: 43-46. PMID 9557223 DOI: 10.1159/000017864  1
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