| Year |
Citation |
Score |
| 2018 |
Huang Z, Wu J, Zou Y, Yuan H, Zhang Y, Fei Y, Bhardwaj A, Kaur J, Knaus EE, Zhang Y. Glutathione S-Transferase π-Activatable O2-(Sulfonylethyl Derived) Diazeniumdiolates Potently Suppress Melanoma In Vitro and In Vivo. Journal of Medicinal Chemistry. PMID 29420887 DOI: 10.1021/Acs.Jmedchem.7B01178 |
0.375 |
|
| 2017 |
Zou Y, Yan C, Knaus EE, Zhang H, Zhang Y, Huang Z. Discovery of phosphorodiamidate mustard-based O2-phosphorylated diazeniumdiolates with potent anticancer activity Rsc Advances. 7: 18893-18899. DOI: 10.1039/C7Ra00401J |
0.314 |
|
| 2014 |
Abdellatif KR, Moawad A, Knaus EE. Synthesis of new 1-(4-methane(amino)sulfonylphenyl)-5-(4-substituted-aminomethylphenyl)-3-trifluoromethyl-1H-pyrazoles: a search for novel nitric oxide donor anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters. 24: 5015-21. PMID 25304893 DOI: 10.1016/J.Bmcl.2014.09.024 |
0.397 |
|
| 2014 |
Bhardwaj A, Kaur J, Wuest F, Knaus EE. Fluorophore-labeled cyclooxygenase-2 inhibitors for the imaging of cyclooxygenase-2 overexpression in cancer: synthesis and biological studies. Chemmedchem. 9: 109-16, 240. PMID 24376205 DOI: 10.1002/Cmdc.201300355 |
0.312 |
|
| 2013 |
Xia Z, Knaus EE, Wiebe LI. Pharmacokinetics of 3'-O-retinoyl-5-fluoro-2'-deoxyuridine (RFUdR), a dual acting mutually masking prodrug, and its metabolites in tumor bearing mice. Current Drug Delivery. 10: 557-63. PMID 23755721 DOI: 10.2174/15672018113109990038 |
0.521 |
|
| 2013 |
Bhardwaj A, Huang Z, Kaur J, Yang F, Seubert JM, Knaus EE. A diazen-1-ium-1,2-diolate analog of 7-azabenzobicyclo[2.2.1]heptane: synthesis, nitric oxide and nitroxyl release, in vitro hemodynamic, and anti-hypertensive studies. Bioorganic & Medicinal Chemistry Letters. 23: 2769-74. PMID 23541649 DOI: 10.1016/J.Bmcl.2013.02.040 |
0.334 |
|
| 2012 |
Huang Z, Kaur J, Bhardwaj A, Alsaleh N, Reisz JA, DuMond JF, King SB, Seubert JM, Zhang Y, Knaus EE. O2-sulfonylethyl protected isopropylamine diazen-1-ium-1,2-diolates as nitroxyl (HNO) donors: synthesis, β-elimination fragmentation, HNO release, positive inotropic properties, and blood pressure lowering studies. Journal of Medicinal Chemistry. 55: 10262-71. PMID 23072318 DOI: 10.1021/Jm301303P |
0.37 |
|
| 2012 |
Kaur J, Bhardwaj A, Huang Z, Knaus EE. N-1 and C-3 substituted indole Schiff bases as selective COX-2 inhibitors: synthesis and biological evaluation. Bioorganic & Medicinal Chemistry Letters. 22: 2154-9. PMID 22361134 DOI: 10.1016/J.Bmcl.2012.01.130 |
0.372 |
|
| 2012 |
Kaur J, Bhardwaj A, Huang Z, Knaus EE. Aspirin analogues as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, nitric oxide release, molecular modeling, and biological evaluation as anti-inflammatory agents. Chemmedchem. 7: 144-50. PMID 22095955 DOI: 10.1002/Cmdc.201100460 |
0.392 |
|
| 2012 |
Wiebe LI, Sun W, Zhou A, Yang J, Sjuvarsson EV, Eriksson S, Paproski RJ, Cass CE, Kumar P, Knaus EE. Biochemistry and biology of 2'-Fluoro-2'-deoxythymidine (FT), a putative highly selective substrate for thymidine kinase type 2 (TK2). Current Radiopharmaceuticals. 5: 38-46. PMID 21864241 DOI: 10.2174/1874471011205010038 |
0.547 |
|
| 2011 |
Abdur Rahim M, Praveen Rao PN, Bhardwaj A, Kaur J, Huang Z, Knaus EE. Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 6074-80. PMID 21890358 DOI: 10.1016/J.Bmcl.2011.08.053 |
0.349 |
|
| 2011 |
Abdellatif KR, Huang Z, Chowdhury MA, Kaufman S, Knaus EE. A diazen-1-ium-1,2-diolated nitric oxide donor ester prodrug of 3-(4-hydroxymethylphenyl)-4-(4-methanesulfonylphenyl)-5H-furan-2-one: synthesis, biological evaluation and nitric oxide release studies. Bioorganic & Medicinal Chemistry Letters. 21: 3951-6. PMID 21641217 DOI: 10.1016/J.Bmcl.2011.05.017 |
0.363 |
|
| 2011 |
Huang Z, Velázquez CA, Abdellatif KR, Chowdhury MA, Reisz JA, DuMond JF, King SB, Knaus EE. Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies. Journal of Medicinal Chemistry. 54: 1356-64. PMID 21280601 DOI: 10.1021/Jm101403G |
0.344 |
|
| 2011 |
Abdellatif KR, Velázquez CA, Huang Z, Chowdhury MA, Knaus EE. Triaryl (Z)-olefins suitable for radiolabeling with iodine-124 or fluorine-18 radionuclides for positron emission tomography imaging of estrogen positive breast tumors. Bioorganic & Medicinal Chemistry Letters. 21: 1195-8. PMID 21237640 DOI: 10.1016/J.Bmcl.2010.12.091 |
0.314 |
|
| 2010 |
Chowdhury MA, Huang Z, Abdellatif KR, Dong Y, Yu G, Velázquez CA, Knaus EE. Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1,2-dihydropyrid-2-one ring system: a search for novel cyclooxygenase and lipoxygenase inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 5776-80. PMID 20727750 DOI: 10.1016/J.Bmcl.2010.07.132 |
0.404 |
|
| 2010 |
Huang Z, Velázquez C, Abdellatif K, Chowdhury M, Jain S, Reisz J, Dumond J, King SB, Knaus E. Acyclic triaryl olefins possessing a sulfohydroxamic acid pharmacophore: synthesis, nitric oxide/nitroxyl release, cyclooxygenase inhibition, and anti-inflammatory studies. Organic & Biomolecular Chemistry. 8: 4124-30. PMID 20664853 DOI: 10.1039/C005066K |
0.352 |
|
| 2010 |
Abdellatif KR, Velázquez CA, Huang Z, Chowdhury MA, Knaus EE. Triaryl (Z)-olefins suitable for radiolabeling with carbon-11 or fluorine-18 radionuclides for positron emission tomography imaging of cyclooxygenase-2 expression in pathological disease. Bioorganic & Medicinal Chemistry Letters. 20: 5245-50. PMID 20655211 DOI: 10.1016/J.Bmcl.2010.06.155 |
0.333 |
|
| 2010 |
Abdellatif KR, Chowdhury MA, Velázquez CA, Huang Z, Dong Y, Das D, Yu G, Suresh MR, Knaus EE. Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies. Bioorganic & Medicinal Chemistry Letters. 20: 4544-9. PMID 20576432 DOI: 10.1016/J.Bmcl.2010.06.022 |
0.381 |
|
| 2010 |
Yu G, Praveen Rao PN, Chowdhury MA, Abdellatif KR, Dong Y, Das D, Velázquez CA, Suresh MR, Knaus EE. Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase. Bioorganic & Medicinal Chemistry Letters. 20: 2168-73. PMID 20202839 DOI: 10.1016/J.Bmcl.2010.02.040 |
0.413 |
|
| 2010 |
Chowdhury MA, Abdellatif KR, Dong Y, Yu G, Huang Z, Rahman M, Das D, Velázquez CA, Suresh MR, Knaus EE. Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies. Bioorganic & Medicinal Chemistry Letters. 20: 1324-9. PMID 20097072 DOI: 10.1016/J.Bmcl.2010.01.014 |
0.38 |
|
| 2010 |
Yu G, Chowdhury MA, Abdellatif KR, Dong Y, Praveen Rao PN, Das D, Velázquez CA, Suresh MR, Knaus EE. Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. Bioorganic & Medicinal Chemistry Letters. 20: 896-902. PMID 20045320 DOI: 10.1016/J.Bmcl.2009.12.073 |
0.397 |
|
| 2009 |
Stahlschmidt A, Khalili P, Sun W, MacHulla HJ, Knaus EE, Wiebe LI. Biodistribution and imaging of 1-(2-deoxy -β-D-ribofuranosyl)-2,4- difluoro-5-[123/125I]iodobenzene (dRF[123/125I]IB), a nonpolar thymidine-mimetic nucleoside, in rats and tumor-bearing mice Nucleosides, Nucleotides and Nucleic Acids. 28: 379-393. PMID 20183590 DOI: 10.1080/15257770903051072 |
0.536 |
|
| 2009 |
Chowdhury MA, Abdellatif KR, Dong Y, Das D, Yu G, Velázquez CA, Suresh MR, Knaus EE. Synthesis and biological evaluation of salicylic acid and N-acetyl-2-carboxybenzenesulfonamide regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. Bioorganic & Medicinal Chemistry Letters. 19: 6855-61. PMID 19884005 DOI: 10.1016/J.Bmcl.2009.10.083 |
0.393 |
|
| 2009 |
Abdellatif KR, Chowdhury MA, Dong Y, Das D, Yu G, Velázquez C, Suresh MR, Knaus EE. Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies. Bioorganic & Medicinal Chemistry. 17: 5182-8. PMID 19500994 DOI: 10.1016/J.Bmc.2009.05.046 |
0.389 |
|
| 2009 |
Abdellatif KR, Chowdhury MA, Dong Y, Das D, Yu G, Velázquez CA, Suresh MR, Knaus EE. Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies. Bioorganic & Medicinal Chemistry Letters. 19: 3014-8. PMID 19419861 DOI: 10.1016/J.Bmcl.2009.04.059 |
0.37 |
|
| 2009 |
Chowdhury MA, Abdellatif KR, Dong Y, Das D, Suresh MR, Knaus EE. Synthesis of celecoxib analogues possessing a N-difluoromethyl-1,2-dihydropyrid-2-one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. Journal of Medicinal Chemistry. 52: 1525-9. PMID 19296694 DOI: 10.1021/Jm8015188 |
0.358 |
|
| 2009 |
Chowdhury MA, Abdellatif KR, Dong Y, Rahman M, Das D, Suresh MR, Knaus EE. Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. Bioorganic & Medicinal Chemistry Letters. 19: 584-8. PMID 19136259 DOI: 10.1016/J.Bmcl.2008.12.066 |
0.393 |
|
| 2009 |
Sun W, Wilson J, Kumar P, Knaus E, Wiebe L. Radiosynthesis of 2-deoxy-2-[18F]fluorothymidine ([18F]FT), a Putative PET Agent for Imaging HSV-TK Expression Current Radiopharmaceuticalse. 2: 75-82. DOI: 10.2174/1874471010902010075 |
0.544 |
|
| 2009 |
Chowdhury MA, Chen H, Abdellatif KRA, Dong Y, Petruk KC, Knaus EE. Synthesis of new 1-(2-, 3-, or 4-methanesulfonylphenyl)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: A search for novel cyclooxygenase and lipoxygenase inhibitors Journal of Heterocyclic Chemistry. 46: 58-61. DOI: 10.1002/Jhet.23 |
0.397 |
|
| 2008 |
Chowdhury MA, Abdellatif KR, Dong Y, Das D, Suresh MR, Knaus EE. Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. Bioorganic & Medicinal Chemistry Letters. 18: 6138-41. PMID 18945614 DOI: 10.1016/J.Bmcl.2008.10.009 |
0.392 |
|
| 2008 |
Chowdhury MA, Abdellatif KR, Dong Y, Knaus EE. Synthesis of new 4-[2-(4-methyl(amino)sulfonylphenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-1,2,3,6-tetrahydropyridines: a search for novel nitric oxide donor anti-inflammatory agents. Bioorganic & Medicinal Chemistry. 16: 8882-8. PMID 18789699 DOI: 10.1016/J.Bmc.2008.08.059 |
0.384 |
|
| 2008 |
Stahlschmidt A, Machulla HJ, Reischl G, Knaus EE, Wiebe LI. Radioiodination of 1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-iodobenzene (dRFIB), a putative thymidine mimic nucleoside for cell proliferation studies. Applied Radiation and Isotopes : Including Data, Instrumentation and Methods For Use in Agriculture, Industry and Medicine. 66: 1221-8. PMID 18662615 DOI: 10.1016/j.apradiso.2008.01.014 |
0.502 |
|
| 2008 |
Chowdhury MA, Chen H, Abdellatif KR, Dong Y, Petruk KC, Knaus EE. Synthesis and biological evaluation of 1-(benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: a novel class of 5-lipoxygenase inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 4195-8. PMID 18541424 DOI: 10.1016/J.Bmcl.2008.05.071 |
0.372 |
|
| 2008 |
Abdellatif KR, Chowdhury MA, Dong Y, Knaus EE. Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 1-(4-methanesulfonylphenyl)-5-aryl-1H-pyrazol-3-carboxylic acids: synthesis, nitric oxide release studies and anti-inflammatory activities. Bioorganic & Medicinal Chemistry. 16: 6528-34. PMID 18513975 DOI: 10.1016/J.Bmc.2008.05.028 |
0.381 |
|
| 2008 |
Velázquez CA, Chen QH, Citro ML, Keefer LK, Knaus EE. Second-generation aspirin and indomethacin prodrugs possessing an O(2)-(acetoxymethyl)-1-(2-carboxypyrrolidin-1-yl)diazenium-1,2-diolate nitric oxide donor moiety: design, synthesis, biological evaluation, and nitric oxide release studies. Journal of Medicinal Chemistry. 51: 1954-61. PMID 18314945 DOI: 10.1021/Jm701450Q |
0.365 |
|
| 2008 |
Li HF, Winkeler A, Moharram S, Knaus EE, Dittmar K, Stöckle M, Heiss WD, Wiebe LI, Jacobs AH, Jacob AJ. In vivo evaluation of the uptake of [(123)I]FIAU, [(123)I]IVFRU and [(123)I]IVFAU by normal mouse brain: potential for noninvasive assessment of HSV-1 thymidine kinase gene expression in gliomas. Nucleosides, Nucleotides & Nucleic Acids. 27: 57-66. PMID 18188770 DOI: 10.1080/15257770701571933 |
0.518 |
|
| 2008 |
Abdellatif KR, Chowdhury MA, Dong Y, Chen QH, Knaus EE. Diazen-1-ium-1,2-diolated and nitrooxyethyl nitric oxide donor ester prodrugs of anti-inflammatory (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic acids: synthesis, cyclooxygenase inhibition, and nitric oxide release studies. Bioorganic & Medicinal Chemistry. 16: 3302-8. PMID 18096394 DOI: 10.1016/J.Bmc.2007.12.006 |
0.372 |
|
| 2008 |
Chowdhury MA, Dong Y, Chen QH, Abdellatif KR, Knaus EE. Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers. Bioorganic & Medicinal Chemistry. 16: 1948-56. PMID 18023187 DOI: 10.1016/J.Bmc.2007.11.003 |
0.387 |
|
| 2008 |
Abdellatif KRA, Chowdhury MA, Knaus EE. Synthesis of new 1-[4-methane(amino)sulfonylphenyl]-5-[4-(aminophenyl)]-3- trifluoromethyl-1H-pyrazoles Journal of Heterocyclic Chemistry. 45: 1707-1710. DOI: 10.1002/Jhet.5570450623 |
0.314 |
|
| 2007 |
Abdellatif KR, Dong Y, Chen QH, Chowdhury MA, Knaus EE. Novel (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic ester prodrugs possessing a diazen-1-ium-1,2-diolate moiety: design, synthesis, cyclooxygenase inhibition, and nitric oxide release studies. Bioorganic & Medicinal Chemistry. 15: 6796-801. PMID 17764958 DOI: 10.1016/J.Bmc.2007.07.021 |
0.352 |
|
| 2007 |
Cristofoli WA, Wiebe LI, De Clercq E, Andrei G, Snoeck R, Balzarini J, Knaus EE. 5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells. Journal of Medicinal Chemistry. 50: 2851-7. PMID 17518459 DOI: 10.1021/Jm0701472 |
0.548 |
|
| 2007 |
Velázquez CA, Praveen Rao PN, Citro ML, Keefer LK, Knaus EE. O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies. Bioorganic & Medicinal Chemistry. 15: 4767-74. PMID 17509888 DOI: 10.1016/J.Bmc.2007.05.009 |
0.354 |
|
| 2007 |
Zarghi A, Praveen Rao PN, Knaus EE. Synthesis and biological evaluation of methanesulfonamide analogues of rofecoxib: Replacement of methanesulfonyl by methanesulfonamido decreases cyclooxygenase-2 selectivity. Bioorganic & Medicinal Chemistry. 15: 1056-61. PMID 17067801 DOI: 10.1016/J.Bmc.2006.10.023 |
0.396 |
|
| 2007 |
Kaur K, Knaus EE. Synthesis of alkyl 6 -methyl -4 -(2 -pyridyl ) -1,2,3,4 -tetrahydro -2H-pyrimidine-2-one-5-carboxylates for evaluation as calcium channel antagonists Journal of Heterocyclic Chemistry. 44: 745-747. DOI: 10.1002/Jhet.5570440339 |
0.353 |
|
| 2007 |
Kaur K, Knaus EE. Synthesis of alkyl 6‐methyl‐4‐(2‐trifluoromethylphenyl)‐1,2,3,4‐tetrahydro‐2H‐pyrimidine‐2‐one‐5‐carboxylates possessing a N‐3 nitro substituent to determine calcium channel modulation structure‐activity relationships Journal of Heterocyclic Chemistry. 44: 669-672. DOI: 10.1002/Jhet.5570440324 |
0.361 |
|
| 2006 |
Moreau A, Chen QH, Praveen Rao PN, Knaus EE. Design, synthesis, and biological evaluation of (E)-3-(4-methanesulfonylphenyl)-2-(aryl)acrylic acids as dual inhibitors of cyclooxygenases and lipoxygenases. Bioorganic & Medicinal Chemistry. 14: 7716-27. PMID 16931030 DOI: 10.1016/J.Bmc.2006.08.008 |
0.423 |
|
| 2006 |
Chen QH, Rao PN, Knaus EE. Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs). Bioorganic & Medicinal Chemistry. 14: 7898-909. PMID 16904331 DOI: 10.1016/J.Bmc.2006.07.047 |
0.398 |
|
| 2006 |
Zarghi A, Zebardast T, Hakimion F, Shirazi FH, Rao PN, Knaus EE. Synthesis and biological evaluation of 1,3-diphenylprop-2-en-1-ones possessing a methanesulfonamido or an azido pharmacophore as cyclooxygenase-1/-2 inhibitors. Bioorganic & Medicinal Chemistry. 14: 7044-50. PMID 16798002 DOI: 10.1016/J.Bmc.2006.06.022 |
0.4 |
|
| 2006 |
Moreau A, Rao PN, Knaus EE. Synthesis and biological evaluation of acyclic triaryl (Z)-olefins possessing a 3,5-di-tert-butyl-4-hydroxyphenyl pharmacophore: dual inhibitors of cyclooxygenases and lipoxygenases. Bioorganic & Medicinal Chemistry. 14: 5340-50. PMID 16677817 DOI: 10.1016/J.Bmc.2006.03.054 |
0.402 |
|
| 2006 |
Anana R, Rao PN, Chen QH, Knaus EE. Synthesis and biological evaluation of linear phenylethynylbenzenesulfonamide regioisomers as cyclooxygenase-1/-2 (COX-1/-2) inhibitors. Bioorganic & Medicinal Chemistry. 14: 5259-65. PMID 16635574 DOI: 10.1016/J.Bmc.2006.03.050 |
0.384 |
|
| 2006 |
Rao PN, Chen QH, Knaus EE. Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases. Journal of Medicinal Chemistry. 49: 1668-83. PMID 16509583 DOI: 10.1021/Jm0510474 |
0.333 |
|
| 2006 |
Zarghi A, Arfaee S, Rao PN, Knaus EE. Design, synthesis, and biological evaluation of 1,3-diarylprop-2-en-1-ones : a novel class of cyclooxygenase-2 inhibitors. Bioorganic & Medicinal Chemistry. 14: 2600-5. PMID 16356730 DOI: 10.1016/J.Bmc.2005.11.041 |
0.39 |
|
| 2006 |
Wiebe LI, Knaus EE, Iwashina T, Misra H, Lee YW. 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-[36Cl]chlorouracil; Radiosynthesis and Preliminary Biodistribution Studies in an Experimental Murine Tumor Model Collection of Czechoslovak Chemical Communications. 71: 1051-1062. DOI: 10.1135/Cccc20061051 |
0.565 |
|
| 2005 |
Rao PN, Chen QH, Knaus EE. Synthesis and biological evaluation of 1,3-diphenylprop-2-yn-1-ones as dual inhibitors of cyclooxygenases and lipoxygenases. Bioorganic & Medicinal Chemistry Letters. 15: 4842-5. PMID 16143531 DOI: 10.1016/J.Bmcl.2005.07.036 |
0.317 |
|
| 2005 |
Chen QH, Rao PN, Knaus EE. Design, synthesis, and biological evaluation of linear 1-(4-, 3- or 2-methylsulfonylphenyl)-2-phenylacetylenes: a novel class of cyclooxygenase-2 inhibitors. Bioorganic & Medicinal Chemistry. 13: 6425-34. PMID 16099663 DOI: 10.1016/J.Bmc.2005.06.064 |
0.352 |
|
| 2005 |
Moharram S, Zhou A, Kumar P, Knaus EE, Wiebe LI. Radiosynthesis, in vitro cellular uptake and in vivo biodistribution of 3'-O-(3-benzenesulfonylfuroxan-4-yl)-5-[125I]iodo-2'-deoxyuridine, a nucleoside-based nitric oxide donor. Nuclear Medicine and Biology. 32: 641-5. PMID 16026711 DOI: 10.1016/J.Nucmedbio.2005.04.011 |
0.529 |
|
| 2005 |
Morin KW, Duan W, Knaus EE, McEwan AJ, Wiebe LI. A human osteosarcoma cell line expressing herpes simplex type-1 thymidine kinase: studies with radiolabeled (E)-5-(2-iodovinyl)-2'-fluoro-2'-deoxyuridine. Nuclear Medicine and Biology. 32: 459-64. PMID 15982576 DOI: 10.1016/J.Nucmedbio.2005.03.006 |
0.512 |
|
| 2005 |
Velázquez C, Praveen Rao PN, Knaus EE. Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies. Journal of Medicinal Chemistry. 48: 4061-7. PMID 15943479 DOI: 10.1021/Jm050211K |
0.334 |
|
| 2005 |
Chen QH, Rao PN, Knaus EE. Design, synthesis, and biological evaluation of N-acetyl-2-(or 3-)carboxymethylbenzenesulfonamides as cyclooxygenase isozyme inhibitors. Bioorganic & Medicinal Chemistry. 13: 4694-703. PMID 15914011 DOI: 10.1016/J.Bmc.2005.04.069 |
0.338 |
|
| 2005 |
Mojarrad JS, Vo D, Velázquez C, Knaus EE. Design and synthesis of alkyl 7,7-dihalo-3-methyl-5-(nitrophenyl)-2-azabicyclo[4.1.0]hept-3-ene-4-carboxylates with calcium channel antagonist activity. Bioorganic & Medicinal Chemistry. 13: 4085-91. PMID 15911322 DOI: 10.1016/J.Bmc.2005.03.047 |
0.393 |
|
| 2005 |
Velázquez C, Rao PN, McDonald R, Knaus EE. Synthesis and biological evaluation of 3,4-diphenyl-1,2,5-oxadiazole-2-oxides and 3,4-diphenyl-1,2,5-oxadiazoles as potential hybrid COX-2 inhibitor/nitric oxide donor agents. Bioorganic & Medicinal Chemistry. 13: 2749-57. PMID 15781386 DOI: 10.1016/J.Bmc.2005.02.034 |
0.353 |
|
| 2005 |
Chen QH, Rao PN, Knaus EE. Design, synthesis, and biological evaluation of N-acetyl-2-carboxybenzenesulfonamides: a novel class of cyclooxygenase-2 (COX-2) inhibitors. Bioorganic & Medicinal Chemistry. 13: 2459-68. PMID 15755648 DOI: 10.1016/J.Bmc.2005.01.039 |
0.362 |
|
| 2005 |
Nguyen JT, Velázquez CA, Knaus EE. Hantzsch 1,4-dihydropyridines containing a diazen-1-ium-1,2-diolate nitric oxide donor moiety to study calcium channel antagonist structure-activity relationships and nitric oxide release. Bioorganic & Medicinal Chemistry. 13: 1725-38. PMID 15698790 DOI: 10.1016/J.Bmc.2004.12.002 |
0.367 |
|
| 2005 |
Uddin MJ, Rao PN, McDonald R, Knaus EE. Design and synthesis of (E)-1,1,2-triarylethenes: novel inhibitors of the cyclooxygenase-2 (COX-2) isozyme. Bioorganic & Medicinal Chemistry Letters. 15: 439-42. PMID 15603969 DOI: 10.1016/J.Bmcl.2004.10.050 |
0.334 |
|
| 2005 |
Uddin MJ, Praveen Rao PN, Knaus EE. Design and synthesis of (Z)-1,2-diphenyl-1-(4-methanesulfonamidophenyl)alk-1-enes and (Z)-1-(4-azidophenyl)-1,2-diphenylalk-1-enes: novel inhibitors of cyclooxygenase-2 (COX-2) with anti-inflammatory and analgesic activity. Bioorganic & Medicinal Chemistry. 13: 417-24. PMID 15598562 DOI: 10.1016/J.Bmc.2004.10.017 |
0.385 |
|
| 2004 |
Al-Madhoun AS, Eriksson S, Wang ZX, Naimi E, Knaus EE, Wiebe LI. Phosphorylation of isocarbostyril- and difluorophenyl-nucleoside thymidine mimics by the human deoxynucleoside kinases. Nucleosides, Nucleotides & Nucleic Acids. 23: 1865-74. PMID 15628745 DOI: 10.1081/Ncn-200040634 |
0.514 |
|
| 2004 |
Uddin MJ, Praveen Rao PN, McDonald R, Knaus EE. A new class of acyclic 2-alkyl-1,1,2-triaryl (Z)-olefins as selective cyclooxygenase-2 inhibitors. Journal of Medicinal Chemistry. 47: 6108-11. PMID 15537365 DOI: 10.1021/Jm049523Y |
0.384 |
|
| 2004 |
Ohkura K, Sun WY, Seki K, Knaus EE, Wiebe LI. (2S)-2-[1-(2,4-Difluoro-5-iodophenyl)-2-deoxy-beta-D-ribofuranos-5-yloxy]-8-methyl-4H-1,3,2-benzodioxaphosphole 2-oxide. Acta Crystallographica. Section C, Crystal Structure Communications. 60: o789-91. PMID 15528820 DOI: 10.1107/S0108270104021602 |
0.578 |
|
| 2004 |
Uddin MJ, Rao PN, Knaus EE. Design and synthesis of acyclic triaryl (Z)-olefins: a novel class of cyclooxygenase-2 (COX-2) inhibitors. Bioorganic & Medicinal Chemistry. 12: 5929-40. PMID 15498669 DOI: 10.1016/J.Bmc.2004.08.021 |
0.401 |
|
| 2004 |
Uddin MJ, Rao PN, Rahim MA, McDonald R, Knaus EE. A new class of acyclic 2-alkyl-1,2-diaryl (E)-olefins as selective cyclooxygenase-2 (COX-2) inhibitors. Bioorganic & Medicinal Chemistry Letters. 14: 4911-4. PMID 15341950 DOI: 10.1016/J.Bmcl.2004.07.027 |
0.33 |
|
| 2004 |
Rao PN, Uddin MJ, Knaus EE. Design, synthesis, and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors. Journal of Medicinal Chemistry. 47: 3972-90. PMID 15267236 DOI: 10.1021/Jm049939B |
0.381 |
|
| 2004 |
Morin KW, Duan W, Xu L, Zhou A, Moharram S, Knaus EE, McEwan AJ, Wiebe LI. Cytotoxicity and cellular uptake of pyrimidine nucleosides for imaging herpes simplex type-1 thymidine kinase (HSV-1 TK) expression in mammalian cells. Nuclear Medicine and Biology. 31: 623-30. PMID 15219281 DOI: 10.1016/J.Nucmedbio.2004.02.004 |
0.548 |
|
| 2004 |
Velázquez C, Knaus EE. Synthesis and biological evaluation of 1,4-dihydropyridine calcium channel modulators having a diazen-1-ium-1,2-diolate nitric oxide donor moiety for the potential treatment of congestive heart failure. Bioorganic & Medicinal Chemistry. 12: 3831-40. PMID 15210150 DOI: 10.1016/J.Bmc.2004.05.008 |
0.4 |
|
| 2004 |
Smith KM, Ng AM, Yao SY, Labedz KA, Knaus EE, Wiebe LI, Cass CE, Baldwin SA, Chen XZ, Karpinski E, Young JD. Electrophysiological characterization of a recombinant human Na+-coupled nucleoside transporter (hCNT1) produced in Xenopus oocytes. The Journal of Physiology. 558: 807-23. PMID 15194733 DOI: 10.1113/Jphysiol.2004.068189 |
0.507 |
|
| 2004 |
Mojarrad JS, Miri R, Knaus EE. Design and synthesis of methyl 2-methyl-7,7-dihalo-5-phenyl-2-azabicyclo[4.1.0]hept-3-ene-4-carboxylates with calcium channel antagonist activity. Bioorganic & Medicinal Chemistry. 12: 3215-20. PMID 15158789 DOI: 10.1016/J.Bmc.2004.03.063 |
0.368 |
|
| 2004 |
Zarghi A, Praveen Rao PN, Knaus EE. Sulfonamido, azidosulfonyl and N-acetylsulfonamido analogues of rofecoxib: 4-[4-(N-acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone is a potent and selective cyclooxygenase-2 inhibitor. Bioorganic & Medicinal Chemistry Letters. 14: 1957-60. PMID 15050636 DOI: 10.1016/J.Bmcl.2004.01.076 |
0.318 |
|
| 2004 |
Uddin MJ, Rao PN, Knaus EE. Design of acyclic triaryl olefins: a new class of potent and selective cyclooxygenase-2 (COX-2) inhibitors. Bioorganic & Medicinal Chemistry Letters. 14: 1953-6. PMID 15050635 DOI: 10.1016/J.Bmcl.2004.01.075 |
0.389 |
|
| 2004 |
Moharram S, Zhou A, Wiebe LI, Knaus EE. Design and synthesis of 3'- and 5'-O-(3-benzenesulfonylfuroxan-4-yl)-2'-deoxyuridines: biological evaluation as hybrid nitric oxide donor-nucleoside anticancer agents. Journal of Medicinal Chemistry. 47: 1840-6. PMID 15027876 DOI: 10.1021/Jm030544M |
0.58 |
|
| 2004 |
Shan R, Velazquez C, Knaus EE. Syntheses, calcium channel agonist-antagonist modulation activities, and nitric oxide release studies of nitrooxyalkyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(2,1,3-benzoxadiazol-4-yl)pyridine-5-carboxylate racemates, enantiomers, and diastereomers. Journal of Medicinal Chemistry. 47: 254-61. PMID 14695839 DOI: 10.1021/Jm030333H |
0.378 |
|
| 2004 |
Uddin J, Rao PNP, Knaus EE. Methylsulfonyl and hydroxyl substituents induce Z-stereocontrol in the McMurry olefination reaction Synlett. 2004: 1513-1516. DOI: 10.1055/S-2004-829087 |
0.311 |
|
| 2004 |
Fassihi A, Velazquez C, Knaus EE. Synthesis of dialkyl 1,4‐dihydro‐2,6‐dimethylpyridine‐3,5‐dicarboxylates and alkyl 1,4‐dihydro‐2,6‐dimethyl‐3‐nitropyridine‐5‐carboxylates possessing a c‐4 2,4‐dioxo‐1,2,3,4‐tetrahydropyrimidin‐5‐yl (uracil) substituent to determine calcium channel modulation structure‐activity relationships Journal of Heterocyclic Chemistry. 41: 263-266. DOI: 10.1002/Jhet.5570410218 |
0.355 |
|
| 2003 |
Sun WY, Zhou A, Wiebe LI, Knaus EE. Cyclosaligenyl pronucleotides of 5-iodo and 5-trifluoromethyl-1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluorobenzene mimics of thymidine: synthesis and evaluation of this pronucleotide monophosphate delivery system for compounds with potential anticancer activity. Nucleosides, Nucleotides & Nucleic Acids. 22: 2121-32. PMID 14714761 DOI: 10.1081/Ncn-120026634 |
0.585 |
|
| 2003 |
Khalili P, Naimi E, Sun WY, Knaus EE, Wiebe LI. Dose-dependent pharmacokinetics of 1(2-deoxy-β-D-ribofuranosyl)-2,4-difluoro-5-iodobenzene: A potential mimic of 5-iodo-2′-deoxyuridine Biopharmaceutics and Drug Disposition. 24: 385-395. PMID 14689467 DOI: 10.1002/Bdd.375 |
0.495 |
|
| 2003 |
Uddin MJ, Rao PN, Knaus EE. Design and synthesis of novel celecoxib analogues as selective cyclooxygenase-2 (COX-2) inhibitors: replacement of the sulfonamide pharmacophore by a sulfonylazide bioisostere. Bioorganic & Medicinal Chemistry. 11: 5273-80. PMID 14604691 DOI: 10.1016/J.Bmc.2003.07.005 |
0.356 |
|
| 2003 |
Praveen Rao PN, Amini M, Li H, Habeeb AG, Knaus EE. Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors. Journal of Medicinal Chemistry. 46: 4872-82. PMID 14584938 DOI: 10.1021/Jm0302391 |
0.566 |
|
| 2003 |
Khalili P, Naimi E, Sun WY, Knaus EE, Wiebe LI. Biochemical and pharmacokinetic evaluation of a novel pyrimidine nucleoside nitric oxide donor as a potential anticancer/antiviral agent European Journal of Pharmaceutical Sciences. 19: 305-313. PMID 12885396 DOI: 10.1016/S0928-0987(03)00132-5 |
0.55 |
|
| 2003 |
Rao PN, Amini M, Li H, Habeeb AG, Knaus EE. 6-Alkyl, alkoxy, or alkylthio-substituted 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors. Bioorganic & Medicinal Chemistry Letters. 13: 2205-9. PMID 12798335 DOI: 10.1002/CHIN.200341139 |
0.55 |
|
| 2003 |
Naimi E, Zhou A, Khalili P, Wiebe LI, Balzarini J, De Clercq E, Knaus EE. Synthesis of 3′- and 5′-nitrooxy pyrimidine nucleoside nitrate esters: "Nitric oxide donor" agents for evaluation as anticancer and antiviral agents Journal of Medicinal Chemistry. 46: 995-1004. PMID 12620076 DOI: 10.1021/Jm020299R |
0.603 |
|
| 2003 |
Uddin MJ, Rao PNP, Knaus EE. Design and synthesis of novel rofecoxib analogs as potential cyclooxygenase (COX-2) inhibitors: Replacement of the methylsulfonyl pharmacophore by a sulfonylazide bioisostere Journal of Heterocyclic Chemistry. 40: 861-868. DOI: 10.1002/Jhet.5570400518 |
0.364 |
|
| 2003 |
Velazquez C, Vo D, Knaus EE. Syntheses, Calcium Channel Modulation Effects, and Nitric Oxide Release Studies of O2-Alkyl-1-(pyrrolidin-1-yl) diazen-1-ium-1,2-diolate 4-Aryl(heteroaryl)-1,4-dihydro-2,6-dimethyl-3-nitropyridine-5-carboxylates Drug Development Research. 60: 204-216. DOI: 10.1002/Ddr.10285 |
0.438 |
|
| 2002 |
Rahim MA, Rao PN, Knaus EE. Isomeric acetoxy analogues of rofecoxib: a novel class of highly potent and selective cyclooxygenase-2 inhibitors. Bioorganic & Medicinal Chemistry Letters. 12: 2753-6. PMID 12217369 DOI: 10.1016/S0960-894X(02)00537-1 |
0.361 |
|
| 2002 |
Nanda D, de Jong M, Vogels R, Havenga M, Driesse M, Bakker W, Bijster M, Avezaat C, Cox P, Morin K, Naimi E, Knaus E, Wiebe L, Smitt PS. Imaging expression of adenoviral HSV1-tk suicide gene transfer using the nucleoside analogue FIRU. European Journal of Nuclear Medicine and Molecular Imaging. 29: 939-47. PMID 12212546 DOI: 10.1007/S00259-002-0839-9 |
0.542 |
|
| 2002 |
Khalili P, Naimi E, Knaus EE, Wiebe LI. Pharmacokinetics and metabolism of the novel synthetic C-nucleoside, 1-(2-deoxy-β-D-ribofuranosyl)-2,4-difluoro-5-iodobenzene: A potential mimic of 5-iodo-2′-deoxyuridine Biopharmaceutics and Drug Disposition. 23: 105-113. PMID 12173545 DOI: 10.1002/Bdd.301 |
0.57 |
|
| 2002 |
Kumar R, Wang L, Wiebe LI, Knaus EE. Synthesis and biological investigations of 5-substituted pyrimidine nucleosides coupled to a dihydropyridine/pyridinium salt redox chemical delivery system. Archiv Der Pharmazie. 334: 351-6. PMID 11822172 DOI: 10.1002/1521-4184(200112)334:11<351::Aid-Ardp351>3.0.Co;2-D |
0.583 |
|
| 2002 |
Wiebe LI, Knaus EE. Enzyme-targeted, nucleoside-based radiopharmaceuticals for scintigraphic monitoring of gene transfer and expression. Current Pharmaceutical Design. 7: 1893-906. PMID 11772356 DOI: 10.2174/1381612013396817 |
0.485 |
|
| 2002 |
Rahim MA, Rao PNP, Knaus EE. Synthesis of 4‐alkyl‐1,2‐diphenyl‐3,5‐dioxopyrazolidines possessing aryl methylsulfonyl and sulfonamide pharmacophores for evaluation as selective cyclooxygenase‐2 (COX‐2) inhibitors Journal of Heterocyclic Chemistry. 39: 1309-1314. DOI: 10.1002/Jhet.5570390631 |
0.411 |
|
| 2002 |
Rao PNP, Habeeb AG, Knaus EE. Design, syntheses, and evaluation of novel 1,1‐dihalo‐2,3‐diphenylcyclopropanes as potential cyclooxygenase‐2 (COX‐2) inhibitors with analgesic‐antiinflammatory activity Drug Development Research. 55: 79-90. DOI: 10.1002/Ddr.3000 |
0.409 |
|
| 2002 |
Li H, Praveen Rao P, Habeeb AG, Knaus EE. Design, syntheses, and evaluation of 2,3-diphenylcycloprop-2-en-1-ones and oxime derivatives as potential cyclooxygenase-2 (COX-2) inhibitors with analgesic-antiinflammatory activity Drug Development Research. 57: 6-17. DOI: 10.1002/Ddr.10102 |
0.414 |
|
| 2002 |
Vo D, Nguyen JT, McEwen CA, Shan R, Knaus EE. Syntheses, calcium channel agonist-antagonist modulation effects, and nitric oxide release studies of [3-(benzenesulfonyl)furoxan-4-yloxy]alkyl 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-trifluoromethylphenyl, benzofurazan-4-yl, 2-, 3-, or 4-pyridyl)-3-pyridinecarboxylates Drug Development Research. 56: 1-16. DOI: 10.1002/Ddr.10050 |
0.381 |
|
| 2001 |
Naimi E, Duan W, Wiebe LI, Knaus EE. Synthesis of unnatural 7-substituted-1-(2-deoxy-beta-D-ribofuranosyl)isocarbostyrils: "thymine replacement" analogs of deoxythymidine for evaluation as antiviral and anticancer agents. Nucleosides, Nucleotides & Nucleic Acids. 20: 1533-53. PMID 11554544 DOI: 10.1081/Ncn-100105246 |
0.582 |
|
| 2001 |
Habeeb AG, Rao PNP, Knaus EE. Design and synthesis of celecoxib and rofecoxib analogues as selective cyclooxygenase-2 (COX-2) inhibitors: Replacement of sulfonamide and methylsulfonyl pharmacophores by an azido bioisostere Journal of Medicinal Chemistry. 44: 3039-3042. PMID 11520213 DOI: 10.1021/Jm010153C |
0.326 |
|
| 2001 |
Habeeb AG, Rao PNP, Knaus EE. Design and Synthesis of 4,5-Diphenyl-4-isoxazolines: Novel Inhibitors of Cyclooxygenase-2 with Analgesic and Antiinflammatory Activity Journal of Medicinal Chemistry. 44: 2921-2927. PMID 11520200 DOI: 10.1021/Jm0101287 |
0.39 |
|
| 2001 |
Mark BL, Parrish JC, Wang ZX, Wiebe LI, Knaus EE, James MN. (E)-1-(2'-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-(2-iodovinyl)benzene. Acta Crystallographica. Section C, Crystal Structure Communications. 57: 758-60. PMID 11408697 DOI: 10.1107/S0108270101005029 |
0.531 |
|
| 2001 |
Wang ZX, Duan W, Wiebe LI, Balzarini J, De Clercq E, Knaus EE. Synthesis of 1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-substituted-benzenes: "thymine replacement" analogs of thymidine for evaluation as anticancer and antiviral agents. Nucleosides, Nucleotides & Nucleic Acids. 20: 41-58. PMID 11303562 DOI: 10.1081/Ncn-100001436 |
0.577 |
|
| 2001 |
Wang ZX, Duan W, Wiebe LI, Balzarini J, De Clercq E, Knaus EE. Synthesis of 1-(2-deoxy-beta-D-ribofuranosyl)-2,4-difluoro-5-substituted-benzene thymidine mimics, some related alpha-anomers, and their evaluation as antiviral and anticancer agents. Nucleosides, Nucleotides & Nucleic Acids. 20: 11-40. PMID 11303557 DOI: 10.1081/Ncn-100001435 |
0.551 |
|
| 2001 |
Wang ZX, Wiebe LI, Balzarini J, De Clercq E, Knaus EE. Chiral synthesis of 4-[1-(2-deoxy-beta-L-ribofuranosyl)] derivatives of 2-substituted 5-fluoroaniline: "cytosine replacement" analogues of deoxy-beta-L-cytidine. The Journal of Organic Chemistry. 65: 9214-9. PMID 11149873 DOI: 10.1021/Jo000510B |
0.515 |
|
| 2001 |
Wang ZX, Duan W, Wiebe LI, De Clercq E, Balzarini J, Knaus EE. Syntheses of 1-[(2-hydroxyethoxy)methyl]- and 1-[(1,3-dihydroxy-2-propoxy)methyl]- derivatives of 5-substituted-2,4-difluorobenzene: unnatural acyclo thymidine mimics for evaluation as anticancer and antiviral agents. Nucleosides, Nucleotides & Nucleic Acids. 19: 1397-411. PMID 11092311 DOI: 10.1080/15257770008033850 |
0.6 |
|
| 2001 |
Amini M, McEwen C, Knaus EE. Design and syntheses of 4-[3-(1-methoxycarbonyl-1,6-dihydropyridyl)]- and 4-[3-(1-methoxycarbonyl-4-substituted-1,4-dihydropyridyl)]- derivatives of alkyl 1,4-dihydro-2,6-dimethyl-3-nitro-5-pyridine-carboxylates with calcium channel modulating activities Arkivoc. 2001. DOI: 10.3998/Ark.5550190.0002.604 |
0.579 |
|
| 2001 |
Naimi E, Wiebe LI, Balzarini J, De Clercq E, Knaus EE. Synthesis of 1-(2-deoxy-?-D-ribofuranosyl)-2,4- difluoro-5-(2-halo-1-hydroxyethyl)benzenes and related derivatives: ?thymine replacement? analogs of deoxythymidine for evaluation as antiviral and anticancer agents Drug Development Research. 52: 492-499. DOI: 10.1002/Ddr.1151 |
0.605 |
|
| 2000 |
Iqbal N, McEwen CA, Sardari S, Daneshtalab M, Knaus EE. Evaluation of methylthio-, methylsulfinyl-, and methylsulfonyl-analogs of alkanes and alkanoic acids as cardiac inotropic and antifungal agents. Archiv Der Pharmazie. 333: 293-8. PMID 11039185 DOI: 10.1002/1521-4184(20009)333:9<293::Aid-Ardp293>3.0.Co;2-2 |
0.342 |
|
| 2000 |
Parang K, Wiebe LI, Knaus EE. Novel approaches for designing 5'-O-ester prodrugs of 3'-Azido-2',3'-dideoxythymidine (AZT) Current Medicinal Chemistry. 7: 995-1039. PMID 10911016 DOI: 10.2174/0929867003374372 |
0.683 |
|
| 2000 |
Mazumdar G, De M, Mukhopadhyay A, Mazumdar SK, Mazumder N, Das AK, Knaus EE. Ethyl 3-(2'-deoxyuridin-5-yl)-3-hydroxy-2-iodopropanoate, a nucleoside analogue. Acta Crystallographica. Section C, Crystal Structure Communications. 56: 494-5. PMID 10815224 DOI: 10.1107/S0108270100000998 |
0.316 |
|
| 2000 |
Parrish JC, Shan R, Knaus EE, James MN. Racemic isopropyl 1,4-dihydro-2,6-dimethyl-4-(6-methyl-2-pyridyl)-3- nitropyridine-5-carboxylate hemibenzene solvate. Acta Crystallographica. Section C, Crystal Structure Communications. 56: 107-9. PMID 10710689 DOI: 10.1107/S0108270199013049 |
0.323 |
|
| 2000 |
Wang Z, Wiebe LI, Clercq ED, Balzarini J, Knaus EE. Syntheses of 4-[1-(2-deoxy-β-D-ribofuranosyl)]-derivatives of 2-substituted-5-fluoroaniline: "cytosine replacement" analogs of deoxycytidine for evaluation as anticancer and antihuman immunodeficiency virus (anti-HIV) agents Canadian Journal of Chemistry. 78: 1081-1088. DOI: 10.1139/V00-105 |
0.614 |
|
| 2000 |
Agudoawu SA, Knaus EE. Synthesis and analgesic-antiinflammatory activities of ethyl 2-[3-(1-phenoxy(methoxy)carbonyl-4-aryl-(alkyl)-1,4-dihydropyridyl)]acetates Journal of Heterocyclic Chemistry. 37: 303-306. DOI: 10.1002/Jhet.5570370214 |
0.424 |
|
| 2000 |
Habeeb AG, Rao PNP, Knaus EE. Design and syntheses of diarylisoxazoles: Novel inhibitors of cyclooxygenase‐2 (COX‐2) with analgesic‐antiinflammatory activity Drug Development Research. 51: 273-286. DOI: 10.1002/Ddr.9 |
0.364 |
|
| 2000 |
Nguyen JT, McEwen CA, Knaus EE. Hantzsch 1,4-dihydropyridines containing a nitrooxyalkyl ester moiety to study calcium channel antagonist structure-activity relationships and nitric oxide release Drug Development Research. 51: 233-243. DOI: 10.1002/Ddr.4 |
0.398 |
|
| 2000 |
Miri R, McEwen C, Knaus EE. Synthesis and calcium channel modulating effects of modified Hantzsch nitrooxyalkyl 1,4‐dihydro‐2,6‐dimethyl‐3‐nitro‐4‐(pyridinyl or 2‐trifluoromethylphenyl)‐5‐pyridinecarboxylates Drug Development Research. 51: 225-232. DOI: 10.1002/Ddr.3 |
0.368 |
|
| 2000 |
Iqbal N, McEwen C, Knaus EE. Synthesis and calcium channel modulation effects of isopropyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-phenylpyridine-5-carboxylates possessing ortho-, meta-, and para-CH2S(O)nMe and –S(O)nMe (n = 0–2) phenyl substituents Drug Development Research. 51: 177-186. DOI: 10.1002/1098-2299(200011)51:3<177::Aid-Ddr6>3.0.Co;2-A |
0.374 |
|
| 2000 |
Ramesh M, Matowe WC, Wolowyk MW, Knaus EE. Design and syntheses of C‐4 4‐(1‐methoxycarbonyl‐1,2‐dihydropyridyl)‐, and 3‐[1‐methoxycarbonyl‐1,2‐(and 1,6‐)dihydropyridyl]‐, derivatives of alkyl 1,4‐dihydro‐2,6‐dimethyl‐3‐nitro‐5‐pyridinecarboxylates with cardiospecific calcium channel agonist activity Drug Development Research. 49: 245-252. DOI: 10.1002/1098-2299(200004)49:4<245::Aid-Ddr3>3.0.Co;2-# |
0.38 |
|
| 2000 |
Agudoawu S, Li H, Habeeb AG, Rao PNP, Suresh MR, Knaus EE. Design and syntheses of methyl 2-methyl-2-[2-(4-benzoyl-5-phenyl-7-halo-2-azabicyclo[4.1.0]hept-3-ene)]acetates : Novel inhibitors of cyclooxygenase-2 (cox-2) with analgesic-antiinflammatory activity Drug Development Research. 49: 75-84. DOI: 10.1002/(Sici)1098-2299(200002)49:2<75::Aid-Ddr1>3.0.Co;2-# |
0.418 |
|
| 1999 |
Wiebe LI, Knaus EE. Concepts for the design of anti-HIV nucleoside prodrugs for treating cephalic HIV infection. Advanced Drug Delivery Reviews. 39: 63-80. PMID 10837768 DOI: 10.1016/S0169-409X(99)00020-4 |
0.559 |
|
| 1999 |
Ramesh M, Matowe WC, Wolowyk MW, Knaus EE. Synthesis and calcium channel antagonist activity of dialkyl 1,4-dihydro-2,6-dimethyl-4-[4-(1-methoxycarbonyl-1,4-dihydropyridyl)]-3,5-pyridinedicarboxylates Archiv Der Pharmazie. 332: 385-388. PMID 10605379 DOI: 10.1002/(Sici)1521-4184(199911)332:11<385::Aid-Ardp385>3.0.Co;2-9 |
0.377 |
|
| 1999 |
Yiu S, Knaus EE. Synthesis, calcium channel antagonist activity, and anticonvulsant activity of 3-ethyl 5-methyl 1,4-dihydro-2-[(2-hydroxyethoxy) methyl]-6-methyl-4-(2,3-dichlorophenyl)-3,5-pyridinedicarboxylate coupled to a 1-methyl-1,4-dihydropyridyl-3-carbonyl chemical delivery system. Archiv Der Pharmazie. 332: 363-367. PMID 10575370 DOI: 10.1002/(Sici)1521-4184(199910)332:10<363::Aid-Ardp363>3.0.Co;2-T |
0.353 |
|
| 1999 |
Xia Z, Wiebe LI, Miller GG, Knaus EE. Synthesis and biological evaluation of butanoate, retinoate, and bis(2,2,2-trichloroethyl)phosphate derivatives of 5-fluoro-2'-deoxyuridine and 2',5-difluoro-2'-deoxyuridine as potential dual action anticancer prodrugs. Archiv Der Pharmazie. 332: 286-94. PMID 10489539 DOI: 10.1002/(Sici)1521-4184(19998)332:8<286::Aid-Ardp286>3.0.Co;2-9 |
0.563 |
|
| 1999 |
Wiebe LI, Knaus EE, Morin KW. Radiolabelled pyrimidine nucleosides to monitor the expression of HSV-1 thymidine kinase in gene therapy. Nucleosides & Nucleotides. 18: 1065-6. PMID 10432739 DOI: 10.1080/15257779908041646 |
0.511 |
|
| 1999 |
Agudoawu SA, Yiu SH, Wallace JL, Knaus EE. Synthesis and analgesic activity of 2-methyl-2-[1-(3-benzoyl-4-substituted-1,4-dihydropyridyl)]acetic acid methyl esters, acetic acids, and acetamides. Archiv Der Pharmazie. 332: 213-8. PMID 10399491 DOI: 10.1002/(Sici)1521-4184(19996)332:6<213::Aid-Ardp213>3.0.Co;2-G |
0.386 |
|
| 1999 |
Phillips OA, Murthy KK, Fiakpui CY, Knaus EE. Synthesis of 5-phenyl-10-methyl-7H- pyrimido[4,5-f][1,2,4]triazolo[4,3-a][1,4]diazepine and its evaluation as an anticonvulsant agent Canadian Journal of Chemistry. 77: 216-222. DOI: 10.1139/V98-221 |
0.349 |
|
| 1999 |
Fiakpui CY, Phillips OA, Murthy KSK, Knaus EE. Synthesis and anticonvulsant activities of 5-(2-Chlorophenyl)-7H-pyrido[4,3-f][1,2,4]triazolo[4,3-a][1,4]diazepines Journal of Heterocyclic Chemistry. 36: 377-380. DOI: 10.1002/Jhet.5570360208 |
0.348 |
|
| 1999 |
Arora VK, Knaus EE. Synthesis And Anticonvulsant Activity Of 3-3-(Dimethylamino)-Methyl-5-Methyl-4H-1, 2,4-Triazol-4-Yl-4-(O-Chlorobenzoyl)Pyridine Journal of Heterocyclic Chemistry. 36: 201-203. DOI: 10.1002/Jhet.5570360130 |
0.365 |
|
| 1999 |
Yiu S, Knaus EE. Synthesis of valproate, valerate, and 1-methyl-1, 4-dihydropyridyl-3-carbonyloxy ester derivatives of Hantzsch 1,4-dihydropyridines as potential prodrugs and their evaluation as calcium channel antagonist and anticonvulsant agents Drug Development Research. 48: 26-37. DOI: 10.1002/(Sici)1098-2299(199909)48:1<26::Aid-Ddr4>3.0.Co;2-M |
0.405 |
|
| 1999 |
Murthy KSK, Knaus EE. Synthesis of pyrimido[1,4]diazepin-2-one analogs and their evaluation as anticonvulsant agents Drug Development Research. 46: 155-162. DOI: 10.1002/(Sici)1098-2299(199902)46:2<155::Aid-Ddr9>3.0.Co;2-W |
0.392 |
|
| 1998 |
Parang K, Wiebe LI, Knaus EE. Synthesis, in vitro anti-human immunodeficiency virus structure-activity relationships and biological stability of 5'-O-myristoyl analogue derivatives of 3'-azido-2',3'-dideoxythymidine (AZT) as potential prodrugs Antiviral Chemistry and Chemotherapy. 9: 311-323. PMID 9875410 DOI: 10.1177/095632029800900403 |
0.689 |
|
| 1998 |
Parang K, Wiebe LI, Knaus EE. Pharmacokinetics and tissue distribution of (±)-3'-azido-2',3'-dideoxy-5'-O-(2-bromomyristoyl)thymidine, a prodrug of 3'-azido-2',3'-dideoxythymidine (AZT) in mice Journal of Pharmacy and Pharmacology. 50: 989-996. PMID 9811159 DOI: 10.1111/J.2042-7158.1998.Tb06913.X |
0.641 |
|
| 1998 |
Parang K, Knaus EE, Wiebe LI. Synthesis, in vitro anti-HIV activity, and biological stability of 5'- O-myristoyl analogue derivatives of 3'-fluoro-2',3'dideoxythymidine (FLT) as potential bifunctional prodrugs of FLT Nucleosides and Nucleotides. 17: 987-1008. PMID 9708320 DOI: 10.1080/07328319808004216 |
0.668 |
|
| 1998 |
Iqbal N, Akula MR, Vo D, Matowe WC, McEwen CA, Wolowyk MW, Knaus EE. Synthesis, rotamer orientation, and calcium channel modulation activities of alkyl and 2-phenethyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(3- or 6-substituted-2-pyridyl)-5-pyridinecarboxylates. Journal of Medicinal Chemistry. 41: 1827-37. PMID 9599233 DOI: 10.1021/Jm970529F |
0.369 |
|
| 1998 |
Ramesh M, Matowe WC, Akula MR, Vo D, Dagnino L, Li-Kwong-Ken MC, Wolowyk MW, Knaus EE. Synthesis and calcium channel-modulating effects of alkyl (or cycloalkyl) 1,4-dihydro-2,6-dimethyl-3-nitro-4-pyridyl-5-pyridinecarboxylate racemates and enantiomers. Journal of Medicinal Chemistry. 41: 509-14. PMID 9484501 DOI: 10.1021/Jm9704006 |
0.34 |
|
| 1998 |
Miri R, Howlett SE, Knaus EE. Synthesis and calcium channel modulating effects of isopropyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-(thienyl)-5-pyridinecarboxylates. Archiv Der Pharmazie. 330: 290-4. PMID 9396387 DOI: 10.1002/Ardp.19973300905 |
0.359 |
|
| 1997 |
Degrève B, Andrei G, Izquierdo M, Piette J, Morin K, Knaus EE, Wiebe LI, Basrah I, Walker RT, De Clercq E, Balzarini J. Varicella-zoster virus thymidine kinase gene and antiherpetic pyrimidine nucleoside analogues in a combined gene/chemotherapy treatment for cancer. Gene Therapy. 4: 1107-14. PMID 9415318 DOI: 10.1038/Sj.Gt.3300502 |
0.564 |
|
| 1997 |
Kumar R, Wiebe LI, Knaus EE. Synthesis and antiviral activity of 5-ethyl-5-halo-6-alkoxy-(or azido)-5,6-dihydro-2'-deoxyuridine diastereomers as potential prodrugs to 5-ethyl-2'-deoxyuridine. Archiv Der Pharmazie. 330: 259-63. PMID 9361522 DOI: 10.1002/Ardp.19973300806 |
0.577 |
|
| 1997 |
Morin KW, Atrazheva ED, Knaus EE, Wiebe LI. Synthesis and cellular uptake of 2'-substituted analogues of (E)-5-(2-[125I]iodovinyl)-2'-deoxyuridine in tumor cells transduced with the herpes simplex type-1 thymidine kinase gene. Evaluation as probes for monitoring gene therapy. Journal of Medicinal Chemistry. 40: 2184-90. PMID 9216837 DOI: 10.1021/Jm9606406 |
0.572 |
|
| 1997 |
Parang K, Wiebe LI, Knaus EE, Huang JS, Tyrrell DL, Csizmadia F. In vitro antiviral activities of myristic acid analogs against human immunodeficiency and hepatitis B viruses Antiviral Research. 34: 75-90. PMID 9191015 DOI: 10.1016/S0166-3542(96)01022-4 |
0.669 |
|
| 1997 |
Anana RD, Ng H, Howlett SE, Knaus EE. Synthesis and smooth muscle calcium channel effects of dialkyl 1,4-dihydro-2,6-dimethyl-4-aryl-3,5-pyridinedicarboxylates containing a nitrone moiety in the 4-aryl substituent. Archiv Der Pharmazie. 330: 53-8. PMID 9167447 DOI: 10.1002/Ardp.19973300303 |
0.425 |
|
| 1997 |
Yiu S, Knaus EE. Syntheses, Calcium Channel Antagonist and Anticonvulsant Activities of Substituted 1,4-Dihydro-3,5-pyridinedicarboxylates Containing Various 3-Alkyl Ester Substituents Archiv Der Pharmazie. 330: 35-43. PMID 9112813 DOI: 10.1002/Ardp.19973300109 |
0.334 |
|
| 1997 |
Parang K, Wiebe LI, Knaus EE. Syntheses and biological evaluation of 5'-O-myristoyl derivatives of thymidine against human immunodeficiency virus Antiviral Chemistry and Chemotherapy. 8: 417-427. DOI: 10.1177/095632029700800504 |
0.666 |
|
| 1997 |
Agudoawu SA, Yiu S, Knaus EE. Synthesis of 2-methyl-2-[1-(3-benzoyl-4-phenyl-1,4-dihydropyridyl)]acetic acid methyl ester, acetic acid, and acetamide analogs as potential antiarthritic agents Canadian Journal of Chemistry. 75: 1106-1109. DOI: 10.1139/V97-131 |
0.32 |
|
| 1997 |
Iqbal N, Wei Z, Baker GB, Knaus EE. Synthesis of 4,4-bis(2-methylphenyl)-3-butenyl (and butyl) analogs of 4-phenyl-1,4- and 6-phenyl-1,6-dihydropyridine-3-carboxylic acids and their evaluation as neuronal GABA-uptake inhibitors Canadian Journal of Chemistry. 75: 601-610. DOI: 10.1139/V97-071 |
0.406 |
|
| 1997 |
Kumar R, Wiebe LI, Knaus EE. Synthesis of 5-(1-azido-2-haloethyl)arabinouridines Journal of Heterocyclic Chemistry. 34: 1369-1370. DOI: 10.1002/Jhet.5570340445 |
0.544 |
|
| 1997 |
Anana RD, Knaus EE. Synthesis of Dialkyl 1,4-Dihydro-2,6-dimethyl-4-(heteroaryl)-pyridine-3,5-dicarboxylates as Calcium Channel Antagonists Journal of Heterocyclic Chemistry. 34: 585-588. DOI: 10.1002/Jhet.5570340240 |
0.364 |
|
| 1997 |
Iqbal N, Triggle CR, Knaus EE. Novel Hantzsch 1,4-dihydropyridines to study the structure-function relationships of calcium channels and photoinduced relaxation Drug Development Research. 42: 120-130. DOI: 10.1002/(Sici)1098-2299(199711/12)42:3/4<120::Aid-Ddr3>3.0.Co;2-S |
0.404 |
|
| 1996 |
Parang K, Knaus EE, Wiebe LI, Sardari S, Daneshtalab M, Csizmadia F. Synthesis and antifungal activities of myristic acid analogs Archiv Der Pharmazie. 329: 475-482. PMID 8997896 DOI: 10.1002/Ardp.19963291102 |
0.664 |
|
| 1996 |
Yiu S, Knaus EE. Synthesis, Biological Evaluation, Calcium Channel Antagonist Activity, and Anticonvulsant Activity of Felodipine Coupled to a Dihydropyridine−Pyridinium Salt Redox Chemical Delivery System Journal of Medicinal Chemistry. 39: 4576-4582. PMID 8917646 DOI: 10.1021/Jm960531R |
0.321 |
|
| 1996 |
Anana RD, Knaus EE. Synthesis and Smooth Muscle Calcium Channel Antagonist Effects of Alkyl 1,4-Dihydro-2,6-dimethyl-4-(pyridinyl)-5-[2-(4,5-dihydro-4,4-dimethyloxazolin-2-yl)]-3-pyridinecarboxylates Archiv Der Pharmazie. 329: 408-412. PMID 8915102 DOI: 10.1002/Ardp.19963290807 |
0.399 |
|
| 1996 |
Iqbal N, Knaus EE. Synthesis and Smooth Muscle Calcium Channel Antagonist Effects of Dialkyl 1,4‐Dihydro‐2,6‐dimethyl‐4‐aryl‐3,5‐pyridinedicarboxylates Containing a Nitrooxy or Nitrophenyl Moiety in the 3‐Alkyl Ester Substituent Archiv Der Pharmazie. 329: 23-26. PMID 8687280 DOI: 10.1002/Ardp.19963290105 |
0.385 |
|
| 1996 |
Wang L, Morin KW, Kumar R, Cheraghali M, Todd KG, Baker GB, Knaus EE, Wiebe LI. In vivo biodistribution, pharmacokinetic parameters, and brain uptake of 5-halo-y-methoxy(or ethoxy)-5,6-dihydro-3'-azido-3'-deoxythymidine diastereomers as potential prodrugs of 3'-azido-3'-deoxythymidine. Journal of Medicinal Chemistry. 39: 826-33. PMID 8632406 DOI: 10.1021/Jm9408326 |
0.525 |
|
| 1996 |
Kumar R, Wiebe LI, Knaus EE. Synthesis of 5-(1-azidovinyl) and 5-[2-(1-azirinyl)] analogs of 2′-deoxyuridine Canadian Journal of Chemistry. 74: 1609-1615. DOI: 10.1139/V96-178 |
0.583 |
|
| 1996 |
Kumar R, Wang L, Wiebe LI, Knaus EE. Synthesis, In Vitro Biological Stability, and Anti-HIV Activity of 5-Halo (or Methoxy)-6-Alkoxy (Azido or Hydroxy)-5,6-Dihydro-2′,3′-Didehydro-3′-Deoxythymidine Diastereomers as Potential Prodrugs of 2′,3′-Didehydro-3′-deoxythymidine (D4T) Nucleosides and Nucleotides. 15: 265-286. DOI: 10.1080/07328319608002384 |
0.607 |
|
| 1996 |
Iqbal N, Knaus EE. Synthesis of 3-(2-guanidinoethyl) and 3-[2-(S-methylisothioureidoethyl)] analogs of 5-isopropyl 2,6-dimethyl-1,4-dihydro-4-(2,3-dichlorophenyl)pyridine-3,5-dicarboxylate as a respective releaser of nitric oxide and inhibitor of nitric oxide synthase Journal of Heterocyclic Chemistry. 33: 157-160. DOI: 10.1002/Jhet.5570330127 |
0.368 |
|
| 1996 |
Minakawa N, Matsuda A, Xia Z, Wiebe LI, Knaus EE. Syntheses of [2-2H]-5-ethynyl-1-(β-D-ribofuranosyl)imidazole-4-carboxamide and 5-ethynyl-1-([5-3H]-β-D-ribofuranosyl)imidazole-4-carboxamide (EICAR) Journal of Labelled Compounds and Radiopharmaceuticals. 38: 809-824. DOI: 10.1002/(Sici)1099-1344(199609)38:9<809::Aid-Jlcr899>3.0.Co;2-0 |
0.564 |
|
| 1995 |
Cheraghali AM, Knaus EE, Wiebe LI. Bioavailability and pharmacokinetic parameters for 5-ethyl-2'-deoxyuridine. Antiviral Research. 25: 259-67. PMID 7710272 DOI: 10.1016/0166-3542(94)90008-6 |
0.496 |
|
| 1995 |
Balzarini J, Andrei G, Kumar R, Knaus EE, Wiebe LI, De Clercq E. The cytostatic activity of 5-(1-azidovinyl)-2'-deoxyuridine (AzVDU) against herpes simplex virus thymidine kinase gene-transfected FM3A cells is due to inhibition of thymidylate synthase and enhanced by UV light (lambda = 254 nm) exposure. Febs Letters. 373: 41-4. PMID 7589430 DOI: 10.1016/0014-5793(95)00994-K |
0.536 |
|
| 1995 |
Vo D, Matowe WC, Ramesh M, Iqbal N, Wolowyk MW, Howlett SE, Knaus EE. Syntheses, calcium channel agonist-antagonist modulation activities, and voltage-clamp studies of isopropyl 1,4-dihydro-2,6-dimethyl-3-nitro-4-pyridinylpyridine-5-carboxylate racemates and enantiomers. Journal of Medicinal Chemistry. 38: 2851-9. PMID 7543577 DOI: 10.1021/Jm00015A007 |
0.303 |
|
| 1995 |
Cheraghali AM, Kumar R, Morin KW, De Clercq E, Knaus EE, Wiebe LI. A Comparative Study of 5-ethyl-2′-Deoxyuridine and Selected Lipophilic 5,6-Dihydro Double/Triple Prodrugs Antiviral Chemistry and Chemotherapy. 6: 356-364. DOI: 10.1177/095632029500600602 |
0.584 |
|
| 1995 |
Cheraghali AM, Morin KW, Kumar R, Knaus EE, Wiebe LI. Accumulation of 5-Ethyl-2′-deoxyuridine and its 5,6-Dihydro Prodrugs in Murine Lung and its Potential Clinical Application Journal of Pharmacy and Pharmacology. 47: 595-600. DOI: 10.1111/J.2042-7158.1995.Tb06721.X |
0.524 |
|
| 1995 |
Wiebe L, Knaus E, Cheraghali AM, Kumar R, Morin K, Wang L. 5-Halo-6-alkoxy-5,6-dihydro-pyrimidine Nucleosides: Antiviral Nucleosides or Nucleoside Prodrugs? Nucleosides, Nucleotides and Nucleic Acids. 14: 501-505. DOI: 10.1080/15257779508012413 |
0.552 |
|
| 1995 |
Iqbal N, Knaus EE. Synthesis and Calcium Channel Modulating Effects of Alkyl 1,4‐Dihydro‐2,6‐dimethyl‐4‐(pyridinyl or 2‐trifluoromethylphenyl)‐5‐(1H‐tetrazol‐5‐yl)‐3‐pyridinecarboxylates Archiv Der Pharmazie. 328: 750-754. DOI: 10.1002/Ardp.19953281104 |
0.383 |
|
| 1994 |
Morin KW, Wiebe LI, Knaus EE. Synthesis of brain-targeted 1-(2-deoxy-2-fluoro-beta-D-ribofuranosyl)-(E)-5-(2-iodovinyl)uracil coupled to a dihydropyridine <---> pyridinium salt redox chemical-delivery system. Carbohydrate Research. 249: 109-16. PMID 8252549 DOI: 10.1016/0008-6215(93)84064-D |
0.576 |
|
| 1994 |
Cheraghali AM, Kumar R, Wang L, Knaus EE, Wiebe LI. Synthesis, biotransformation, pharmacokinetics, and antiviral properties of 5-ethyl-5-halo-6-methoxy-5,6-dihydro-2'-deoxyuridine diastereomers. Biochemical Pharmacology. 47: 1615-25. PMID 8185676 DOI: 10.1016/0006-2952(94)90540-1 |
0.565 |
|
| 1994 |
Kumar R, Wang L, Wiebe LI, Knaus EE. Synthesis, in vitro biological stability, and anti-HIV activity of 5-halo-6-alkoxy(or azido)-5,6-dihydro-3'-azido-3'-deoxythymidine diastereomers as potential prodrugs to 3'-azido-3'-deoxythymidine (AZT). Journal of Medicinal Chemistry. 37: 4297-306. PMID 7996541 DOI: 10.1021/Jm00051A006 |
0.61 |
|
| 1994 |
Kumar R, Knaus EE, Wiebe LF, Allen TM. Synthesis of 5-[1-hydroxy (or methoxy)-2,2-dihaloethyl]-2′-deoxyuridines with antiviral and cytotoxic activity Antiviral Research. 24: 315-325. PMID 7993076 DOI: 10.1016/0166-3542(94)90078-7 |
0.402 |
|
| 1994 |
Kumar R, Wang L, Wiebe LI, Knaus EE. Synthesis and antiviral (HIV-1, HBV) activities of 5-halo-6-methoxy(or azido)-5,6-dihydro-3'-fluoro-3'-deoxythymidine diastereomers. Potential prodrugs to 3'-fluoro-3'-deoxythymidine. Journal of Medicinal Chemistry. 37: 3554-60. PMID 7932583 DOI: 10.1021/Jm00047A013 |
0.589 |
|
| 1994 |
Kumar R, Wiebe LI, Knaus EE. A mild and efficient methodology for the synthesis of 5-halogeno uracil nucleosides that occurs via a 5-halogeno-6-azido-5,6-dihydro intermediate Canadian Journal of Chemistry. 72: 2005-2010. DOI: 10.1139/V94-256 |
0.595 |
|
| 1994 |
Zhong-Yong W, Knaus EE. Asymmetric synthesis of both enantiomers of vigabatrin®: An approach using methionine as the chiral pool Tetrahedron. 50: 5569-5578. DOI: 10.1016/S0040-4020(01)85629-5 |
0.325 |
|
| 1994 |
Wei Z, Knaus EE. A regioselective tandem reduction — Wittig-Horner reaction involving the α-ester moiety of diethyl aspartate or glutamate Tetrahedron Letters. 35: 2305-2308. DOI: 10.1016/0040-4039(94)85205-7 |
0.314 |
|
| 1993 |
Kumar R, Wiebe LI, Knaus EE. Synthesis and antiviral activity of novel 5-(1-azido-2-haloethyl) and 5-(1-azido-, amino-, or methoxyethyl) analogs of 2'-deoxyuridine. Journal of Medicinal Chemistry. 36: 2470-4. PMID 8394933 DOI: 10.1021/Jm00069A004 |
0.604 |
|
| 1993 |
Blanchard H, James MNG, Kumar R, Wiebe LI, Knaus EE. Structure of (+)-(5R,6R)-5-chloro-6-methoxy-5,6-dihydro-1-(2',3'-didehydro-2',3'-dideoxy-β-d-glycero-2-enopentofuranosyl)thymine Acta Crystallographica Section C-Crystal Structure Communications. 49: 246-250. DOI: 10.1107/S0108270192003470 |
0.533 |
|
| 1993 |
Kumar R, Wiebe LI, Knaus EE. Synthesis and Antiviral Activity of 1-β-D-Arabinofuranosyluracils and Uridines Containing 5-[2-Bromo-2-chloro (or Bromo)-1-Hydroxy (or Methoxy) Ethyl] Substituents Nucleosides and Nucleotides. 12: 537-545. DOI: 10.1080/07328319308021221 |
0.584 |
|
| 1993 |
Kumar R, Knaus EE, Wiebe LI. Synthesis of (E)-5-(2-cIOdovinyl)-3′-0-(1-Methyl-1,4-Dihydropyridyl-3 -Carbonyl)-2′-Fluoro-2′-Deoxyuridine (Ivfru-Cds) for Brain Targetted Delivery of Ivfru, an Antiviral Nucleoside Nucleosides and Nucleotides. 12: 895-904. DOI: 10.1080/07328319308018560 |
0.586 |
|
| 1993 |
Knaus E, Kumar P. Synthesis and antiinflammatory activity of 5-(1,2-dihydropyridyl)-tetrazol-2-acetic acids, esters and amides European Journal of Medicinal Chemistry. 28: 881-885. DOI: 10.1016/0223-5234(93)90040-L |
0.409 |
|
| 1993 |
Buolamwini J, Knaus E. Synthesis and antinociceptive activity of 1-methylpiperidylidene-2-(pyridyl)sulfonamides and related dihydropyridyl analogs European Journal of Medicinal Chemistry. 28: 447-453. DOI: 10.1016/0223-5234(93)90012-4 |
0.442 |
|
| 1993 |
Wei Z, Knaus EE. Synthesis of chiral 5-substituted 2-pyrrolidinones: An unusual one-step transformation Tetrahedron Letters. 34: 4439-4442. DOI: 10.1016/0040-4039(93)88053-L |
0.338 |
|
| 1993 |
Fiakpui CY, Arora VK, Knaus EE. Synthesis of 3-alkoxycarbonylaminomethylcarbonylamino-4-benzoyl-1,2-dihydropyridines and their cyclization to 5-phenyl-1,3,8,9-tetrahydro-2H-pyrido[3,4-e]-1,4-diazepin-2-ones Journal of Heterocyclic Chemistry. 30: 699-705. DOI: 10.1002/Jhet.5570300320 |
0.401 |
|
| 1993 |
Phillips OA, Knaus EE. Synthesis of 6,7,8,9‐tetrahydro‐5H‐pyrimido‐[4,5‐b][1,4]diazepine‐6,8‐diones Journal of Heterocyclic Chemistry. 30: 283-285. DOI: 10.1002/Jhet.5570300148 |
0.315 |
|
| 1992 |
Kumar R, Knaus EE, Wiebe LI. Synthesis and Anti-Hiv Activity of 3′-0-Formyl Derivatives of Thymidine and 2′-Deoxyuridine Nucleosides and Nucleotides. 11: 1219-1228. DOI: 10.1080/07328319208018337 |
0.588 |
|
| 1992 |
Buolamwini J, Knaus E. Synthesis and analgesic activity of 3-methyl derivatives of 4-(pyridyl) isosteres of ketobemidone European Journal of Medicinal Chemistry. 27: 81-86. DOI: 10.1016/0223-5234(92)90065-9 |
0.375 |
|
| 1991 |
Kumar R, Knaus E, Wiebe L, Allen T, Tempest M. Synthesis and cytotoxic activity of 5-(1-hydroxy-2-haloethyl)-, 5-oxiranyl- and (E)-5-(2-iodovinyl)-2,4-dichloro (or dimethoxy) pyrimidines European Journal of Medicinal Chemistry. 26: 557-562. DOI: 10.1016/0223-5234(91)90153-E |
0.578 |
|
| 1991 |
Knaus E, Tandon M, Temptest M, Wiebe L. Design, synthesis and configuration of 5-[2,2-Dichloro )or 2-chloro) cyclopropyl]-2′-deoxyuridines Antiviral Research. 15: 44. DOI: 10.1016/0166-3542(91)90088-9 |
0.531 |
|
| 1991 |
Kumar R, Knaus EE, Wiebe LI. Synthesis and properties of 5-(1,2-dihaloethyl)-2′-deoxyuridines and related analogues Journal of Heterocyclic Chemistry. 28: 1917-1925. DOI: 10.1002/Jhet.5570280819 |
0.6 |
|
| 1991 |
Kumar R, Wiebe LI, Knaus EE, Nakashima TT. Aziridination of the uracil 5,6-olefinic bond of 3-N-3′,5′-Di-O-tribenzoyl-5-vinyl-2′-deoxyuridine Journal of Heterocyclic Chemistry. 28: 1467-1468. DOI: 10.1002/Jhet.5570280549 |
0.572 |
|
| 1991 |
Morin KW, Kumar R, Knaus EE, Wiebe LI. Design and synthesis of the 3′-aminocarbonylamino, aminothiocarbonylamino andN-(Hydroxy)guanidinyl derivatives of thymidine as potential anti-HIV agents Journal of Heterocyclic Chemistry. 28: 807-809. DOI: 10.1002/Jhet.5570280346 |
0.614 |
|
| 1991 |
Kumar R, Ji G, Wiebe LI, Knaus EE. Synthesis of brain-targeted 5-iodo-, 5-vinyl- and (E)-5-(2-iodovinyl)-2′-deoxyuridines coupled to a dihydropyridine ⇌ pyridinium salt redox chemical delivery system Journal of Heterocyclic Chemistry. 28: 711-715. DOI: 10.1002/Jhet.5570280327 |
0.595 |
|
| 1991 |
Kumar R, Wiebe LI, Knaus EE, Tempest ML. Synthesis and biological evaluation of 5-(1-alkoxy-2-haloethyl)-2′-deoxyuridines and related uracil analogues Journal of Heterocyclic Chemistry. 28: 237-240. DOI: 10.1002/Jhet.5570280206 |
0.591 |
|
| 1990 |
Akula MR, Matowe WC, Wolowyk MW, Knaus EE. Synthesis and Calcium Channel Antagonist Activity of 3-Arylmethyl 5-Isopropyl l,4-Dihydro-2,6-dimethyl-4-(pyridyl)-3,5-pyridinedicarboxylates Pharmaceutical Research. 7: 919-922. PMID 2235890 DOI: 10.1023/A:1015941706008 |
0.406 |
|
| 1990 |
Wiebe LI, Knaus EE, Gati WP, Iwashina T, McQueen L. Drug-induced perturbations in the in vivo distribution of oncological radiotracers--II. 5-[125I]iodo-2'-deoxyuridine influenced by nitrobenzylthioinosine-5'-phosphate (NBMPR-P) and acyclothymidine (ACT). International Journal of Radiation Applications and Instrumentation. Part a, Applied Radiation and Isotopes. 41: 159-62. PMID 2158945 DOI: 10.1016/0883-2889(90)90101-L |
0.535 |
|
| 1990 |
Mosimann SC, Santarsiero BD, James MNG, Tandon M, Wiebe LI, Knaus EE. Structure of 5-[(1S,2S)-2-chlorocyclopropyl]-1-(2-deoxy-β-D-ribofuranosyl)uracil Acta Crystallographica Section C Crystal Structure Communications. 46: 2115-2117. DOI: 10.1107/S0108270190000634 |
0.543 |
|
| 1990 |
Iwashina T, Knaus EE, Wiebe LI, Xu L, Tyrrell D, Tovell DR. Synthesis and biological properties of (E)-5-(2-[82Br]bromovinyl)-1-(2-deoxy-2-fluoro-β-d-ribofuranosyl)uracil ([82Br]BVFRU) International Journal of Radiation Applications and Instrumentation. Part a. Applied Radiation and Isotopes. 41: 675-678. DOI: 10.1016/0883-2889(90)90083-S |
0.574 |
|
| 1990 |
Iwashina T, Kumar R, Knaus EE, Wiebe LI. An efficient, high specific activity radioiodination of 5-(1-hydroxy/methoxy-2-iodoethyl)-2′-deoxyuridine by isotope exchange labelling in pivalic acid melt Journal of Labelled Compounds and Radiopharmaceuticals. 28: 247-255. DOI: 10.1002/Jlcr.2580280302 |
0.567 |
|
| 1989 |
Kumar R, Wiebe LI, Hall TW, Knaus EE, Tovell DR, Tyrrell DL, Allen TM, Fathi-Afshar R. Synthesis of 5-[1-hydroxy(or methoxy)-2-bromo(or chloro)ethyl]-2'-deoxyuridines and related halohydrin analogues with antiviral and cytotoxic activity. Journal of Medicinal Chemistry. 32: 941-4. PMID 2709380 DOI: 10.1021/Jm00125A003 |
0.574 |
|
| 1989 |
Mercer JR, Xu LH, Knaus EE, Wiebe LI. Synthesis and tumor uptake of 5-82Br- and 5-131I-labeled 5-halo-1-(2-fluoro-2-deoxy-beta-D-ribofuranosyl)uracils. Journal of Medicinal Chemistry. 32: 1289-94. PMID 2524593 DOI: 10.1021/Jm00126A024 |
0.586 |
|
| 1989 |
Tandon M, Wiebe LI, Knaus EE. Synthesis, separation, and absolute configuration of the two 5-(2,2-dibromocyclopropyl) and four 5-(2-bromocyclopropyl) diastereomers of 2′-deoxyuridine Canadian Journal of Chemistry. 67: 1484-1488. DOI: 10.1139/V89-226 |
0.561 |
|
| 1989 |
Moore SA, Santarsiero BD, Lin T, James MNG, Tandon M, Wiebe LI, Knaus EE. Structure of 1-(2-deoxy-β-D-ribofuranosyl)-5-[(1S)-2,2-dibromocyclopropyl]uracil Acta Crystallographica Section C Crystal Structure Communications. 45: 647-650. DOI: 10.1107/S0108270188012867 |
0.49 |
|
| 1989 |
Somayaji VV, Hall TW, Wiebe LI, Knaus EE, Demers JP. Synthesis of [5-14C]-1,1,12,12-tetraethoxy-4,9-diazadodecane dinitrate Journal of Labelled Compounds and Radiopharmaceuticals. 27: 449-455. DOI: 10.1002/Jlcr.2580270412 |
0.571 |
|
| 1989 |
Tandon M, Xu L, Iwashina T, Tovell D, Knaus E, Tyrrell D, Wiebe L. Synthesis and evaluation of {125I}-(E)-5-(2-iodovinyl)-N3-methyl-2′-deoxy-uridine as a potential probe for the non-invasive diagnosis of herpes simplex encephalitis Journal of Labelled Compounds and Radiopharmaceuticals. 26: 93-94. DOI: 10.1002/Jlcr.2580260141 |
0.54 |
|
| 1988 |
Vo D, Agarwal KC, Knaus EE, Allen TM, Fathi-Afshar R. Heterocyclic 1,2-epoxyalkan-3-ones as cytotoxic agents European Journal of Medicinal Chemistry. 23: 39-44. DOI: 10.1016/0223-5234(88)90165-1 |
0.335 |
|
| 1988 |
Somayaji VV, Hall TW, Wiebe LI, Knaus EE. An improved synthesis of [1-14C]-labelled 2-butynedioic acid, succinic acid and succinyl chloride Journal of Labelled Compounds and Radiopharmaceuticals. 25: 1325-1331. DOI: 10.1002/Jlcr.2580251206 |
0.561 |
|
| 1988 |
Warren BK, Knaus EE. Some reactions of 1‐alkyl‐1,2,3,4‐tetrahydropyridines with organic azides. Synthesis of 1‐alkylpiperidylidene‐2‐sulfonamides Journal of Heterocyclic Chemistry. 25: 1379-1381. DOI: 10.1002/Jhet.5570250521 |
0.319 |
|
| 1987 |
Yeung JM, Knaus EE. Synthesis of N-(3,6-dihydro-1(2H)-pyridinyl)benzamides with hyperglycemic-hypoglycemic activity. Journal of Medicinal Chemistry. 30: 104-108. PMID 3806586 DOI: 10.1021/Jm00384A018 |
0.331 |
|
| 1987 |
Dagnino L, Li-Kwong-Ken MC, Wolowyk MW, Wynn H, Triggle CR, Knaus EE. Synthesis and calcium channel antagonist activity of dialkyl 1,4-dihydro-2,6-dimethyl-4-(pyridinyl)-3,5-pyridinedicarboxylates. Journal of Medicinal Chemistry. 29: 2524-9. PMID 3783612 DOI: 10.1021/Jm00162A016 |
0.412 |
|
| 1987 |
Gati WP, Wiebe LI, Knaus EE, Paterson AR. [125I]iodohydroxynitrobenzylthioinosine: a new high-affinity nucleoside transporter probe. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 65: 467-73. PMID 3620162 DOI: 10.1139/O87-060 |
0.511 |
|
| 1987 |
Dagnino L, Li-Kwong-Ken MC, Wynn H, Wolowyk MW, Triggle CR, Knaus EE. Synthesis and calcium channel antagonist activity of dialkyl 4- (dihydropyridinyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylates. Journal of Medicinal Chemistry. 30: 640-6. PMID 3560157 DOI: 10.1021/Jm00387A010 |
0.42 |
|
| 1987 |
Tovell DR, Yacyshyn HP, Misra HK, Knaus EE, Wiebe LI, Samuel J, Gill MJ, Tyrrell DL. Effect of acyclovir on the uptake of 131I-labelled 1-(2'fluoro-2'-deoxy-beta-D-arabinofuranosyl)-5-iodouracil in herpes infected cells. Journal of Medical Virology. 22: 183-8. PMID 3039053 DOI: 10.1002/Jmv.1890220210 |
0.535 |
|
| 1987 |
Mercer JR, Knaus EE, Wiebe LI. Synthesis and tumor uptake of 5-halo-1-(2'-fluoro-2'-deoxy-beta-D-ribofuranosyl)[2-14C]uracils. Journal of Medicinal Chemistry. 30: 670-5. PMID 2951522 DOI: 10.1021/Jm00387A015 |
0.586 |
|
| 1987 |
Fiakpui CY, Knaus EE. An improved synthesis of 1,3-dihydro-1-methyl-5-phenyl-2H-pyrido[3,4-e]-1,4-diazepin-2-one via ortho-directed lithiation of 3-tert-butyl and 3-tert-butoxycarbonylaminopyridine Canadian Journal of Chemistry. 65: 1158-1161. DOI: 10.1139/V87-193 |
0.376 |
|
| 1987 |
El-Badry OM, Knaus EE, McNeill JH. Pyridine and reduced pyridine analogues of cimetidine as histamine H2-receptor antagonists European Journal of Medicinal Chemistry. 22: 579-582. DOI: 10.1016/0223-5234(87)90300-X |
0.317 |
|
| 1987 |
Dagnino L, Li-Kwong-Ken MC, Wolowyk MW, Triggle CR, Knaus EE. Synthesis and calcium channel antagonist activity of dialkyl hexahydro-1,2′,6′-trimethyl[bipyridine]-3′,5′-dicarboxylates European Journal of Medicinal Chemistry. 22: 499-503. DOI: 10.1016/0223-5234(87)90289-3 |
0.398 |
|
| 1987 |
Agrawal VK, Knaus EE, McNeill JH. Pyridine and reduced pyridine analogues of 1,2,5-thiadiazoles as histamine H2-receptor antagonists European Journal of Medicinal Chemistry. 22: 319-323. DOI: 10.1016/0223-5234(87)90269-8 |
0.391 |
|
| 1987 |
Warren BK, Knaus EE. Pyridine and reduced pyridine analogues of 10H-pyrido[3,4-b][1,4]benzothiazines with analgesic activity European Journal of Medicinal Chemistry. 22: 411-415. DOI: 10.1016/0223-5234(87)90028-6 |
0.385 |
|
| 1987 |
Misra HK, Wiebe LI, Knaus EE. Synthesis of [2-14C]-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-fluoro(chloro)uracil Journal of Labelled Compounds and Radiopharmaceuticals. 24: 1107-1116. DOI: 10.1002/Jlcr.2580240912 |
0.587 |
|
| 1987 |
Warren BK, Knaus EE. Some reactions of 1-methyl-(2-phenylethyl)-1,2,3,4-tetrahydropyridines with organic azides. Synthesis of 1-methyl-(2-phenylethyl)piperidylidene-2-sulfonamides Journal of Heterocyclic Chemistry. 24: 1413-1416. DOI: 10.1002/Jhet.5570240537 |
0.36 |
|
| 1987 |
Agarwal KC, Knaus EE. Synthesis and reactions of heterocyclic 2,3-epoxypropionitriles with pyrrolidine Journal of Heterocyclic Chemistry. 24: 15-17. DOI: 10.1002/Jhet.5570240103 |
0.332 |
|
| 1986 |
Wiebe LI, Knaus EE. Drug-induced perturbations in the in vivo distribution of oncological radiotracers--I. 5-Fluoro-6-3H-2'-deoxyuridine influenced by nitrobenzylthioinosine 5'-phosphate (NBMPR-P). International Journal of Radiation Applications and Instrumentation. Part B, Nuclear Medicine and Biology. 13: 257-9. PMID 2945804 DOI: 10.1016/0883-2897(86)90105-4 |
0.526 |
|
| 1986 |
Misra HK, Knaus EE, Wiebe LI, Tyrrell D. Synthesis of 131I, 125I, 123I and 82Br labelled 5-halo-1-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)uracils International Journal of Radiation Applications and Instrumentation. Part a. Applied Radiation and Isotopes. 37: 901-905. DOI: 10.1016/0883-2889(86)90290-X |
0.573 |
|
| 1986 |
Mercer JR, Knaus EE, Wiebe LI. An improved synthesis of 14C-labelled 2,2′-anhydrouridine, 2′-deoxyuridine and 5-ethyl-2′-deoxyuridine International Journal of Radiation Applications and Instrumentation. Part a. Applied Radiation and Isotopes. 37: 613-619. DOI: 10.1016/0883-2889(86)90081-X |
0.562 |
|
| 1985 |
Lee YW, Abrams DN, Wiebe LI, Knaus EE. Tumor uptake of radiolabelled pyrimidine bases and pyrimidine nucleosides in animal models--V. 6-[36Cl]chlorouracil, 6-[82Br]bromouracil and 6-[123I]iodouracil. International Journal of Nuclear Medicine and Biology. 11: 262-6. PMID 6549392 DOI: 10.1016/0047-0740(84)90010-X |
0.509 |
|
| 1985 |
Lee YW, Mercer JR, Wiebe LI, Knaus EE. Tumor uptake of radiolabelled pyrimidine bases and pyrimidine nucleosides in animal models: VI. 1-(3'-[36Cl]-chloro-, 1-(3'-[82Br]-bromo- and 1-(3'-[123I]-Iodo-3'-deoxy-beta-D-arabinofuranosyl)uracil. The International Journal of Applied Radiation and Isotopes. 35: 1057-61. PMID 6526522 DOI: 10.1016/0020-708X(84)90010-3 |
0.565 |
|
| 1985 |
Lee YW, Mercer JR, Knaus EE, Wiebe LI. The synthesis of [36Cl]-, [82Br]- and [123I]-labelled 1-(3'-chloro-(bromo and iodo)-3'-deoxy-beta-D-arabinofuranosyl)uracil. The International Journal of Applied Radiation and Isotopes. 35: 1053-6. PMID 6526521 DOI: 10.1016/0020-708X(84)90009-7 |
0.56 |
|
| 1985 |
Lee YW, Giziewicz JB, Knaus EE, Wiebe LI. Tumor uptake of radiolabelled pyrimidine bases and pyrimidine nucleosides in animal models: VII. [2-14C]-5-ethyl-1-(2'-deoxy-beta-D-ribofuranosyl)uracil. The International Journal of Applied Radiation and Isotopes. 35: 1063-6. PMID 6335492 DOI: 10.1016/0020-708X(84)90011-5 |
0.54 |
|
| 1985 |
Wiebe LI, Flanagan RJ, Helus F, Knapp WH, Knaus EE, Maier-Borst W. Radiolabeled L-fucose for diagnostic oncology: preliminary studies in mice and rats using L-1-14C-fucose. International Journal of Nuclear Medicine and Biology. 12: 111-4. PMID 4044139 DOI: 10.1016/0047-0740(85)90165-2 |
0.517 |
|
| 1985 |
Lee YW, Iwashina T, Gati WP, Knaus EE, Wiebe LI. Tumor uptake of radiolabelled pyrimidine bases and pyrimidine nucleosides in animal models--VIII. Synthesis and tissue distribution of N-[2-(hydroxyethoxy) methyl]-5-[3H]methyluracil. The International Journal of Applied Radiation and Isotopes. 36: 395-8. PMID 4018900 DOI: 10.1016/0020-708X(85)90281-9 |
0.551 |
|
| 1985 |
Ondrus TA, Pednekar PR, Knaus EE. Some reactions of 1-methyl-1,2-dihydropyridines with organic azides. Synthesis and reactions of 1,2,5,6-tetrahydropyridylidene-2-cyan(sulfon)amides and piperidylidene-2-cyan(sulfon)amides Canadian Journal of Chemistry. 63: 2362-2368. DOI: 10.1139/V85-391 |
0.358 |
|
| 1985 |
Dubey SK, Knaus EE. Synthesis of heterocyclic 1,4-dihydropyridylacetic acid derivatives of 6-aminopenicillanic acid and D-α-aminobenzylpenicillin with antibacterial activity Canadian Journal of Chemistry. 63: 559-564. DOI: 10.1139/V85-091 |
0.37 |
|
| 1985 |
Abrams DN, Mercer JR, Knaus EE, Wiebe LI. The synthesis of radiolabelled 1-(2′-Fluoro-2′-deoxy-β-D-ribofuranosyl)-uracil and 1-(2′-chloro-2′-deoxy-β-D-ribofuranosyl)uracil The International Journal of Applied Radiation and Isotopes. 36: 233-238. DOI: 10.1016/0020-708X(85)90074-2 |
0.585 |
|
| 1985 |
Giziewicz J, Gati LJ, Knaus EE, Mercer JR, Flanagan RJ, Wiebe LI. Synthesis of [2-14C]-labelled 2,2′-anhydrouridine and 2'-deoxyuridine derivatives. A convenient route to [2-14C]-labelled 5-ethynyl- and 5-ethyl-2′-deoxyuridine The International Journal of Applied Radiation and Isotopes. 36: 227-231. DOI: 10.1016/0020-708X(85)90073-0 |
0.593 |
|
| 1985 |
Agarwal KC, Knaus EE. Synthesis and reactions of heterocyclic methyl 2-propenoates and 2,3-epoxypropanoates with nucleophiles Journal of Heterocyclic Chemistry. 22: 65-69. DOI: 10.1002/Jhet.5570220117 |
0.354 |
|
| 1984 |
Samuel J, Knaus EE, Wiebe LI, Tyrrell DL. Synthesis of 131I, 125I and 82Br labelled (E)-5-(2-halovinyl)-2'-deoxyuridines. The International Journal of Applied Radiation and Isotopes. 35: 1049-52. PMID 6526520 DOI: 10.1016/0020-708X(84)90008-5 |
0.54 |
|
| 1984 |
Gati WP, Misra HK, Knaus EE, Wiebe LI. Structural modifications at the 2'- and 3'-positions of some pyrimidine nucleosides as determinants of their interaction with the mouse erythrocyte nucleoside transporter. Biochemical Pharmacology. 33: 3325-31. PMID 6497896 DOI: 10.1016/0006-2952(84)90101-1 |
0.532 |
|
| 1984 |
Abrams DN, Lee Y, Knaus EE, Wiebe LI. Synthesis of [6-36Cl]chlorouracil, [6-82Br]bromouracil and [6-123I]iodouracil The International Journal of Applied Radiation and Isotopes. 35: 531-535. DOI: 10.1016/0020-708X(84)90176-5 |
0.555 |
|
| 1984 |
Abrams DN, Knaus EE, Wiebe LI, Helus F, Maier-Borst W. Production of 34m Cl from a gaseous hydrogen sulfide target The International Journal of Applied Radiation and Isotopes. 35: 1045-1048. DOI: 10.1016/0020-708X(84)90007-3 |
0.525 |
|
| 1984 |
Misra HK, Gati WP, Knaus EE, Wiebe LI. Reaction of 1-(2′,3′-epoxy-β-D-lyxofuranosyl)uracil with hydrogen fluoride. The unexpected formation of 1-(3′-fluoro-3′-deoxy-β-D-ribofuranosyl)uracil Journal of Heterocyclic Chemistry. 21: 773-775. DOI: 10.1002/Jhet.5570210327 |
0.558 |
|
| 1982 |
Yeung JM, Corleto LA, Knaus EE. Synthesis of N-[[(substituted-phenyl)carbonyl]amino]-1,2,3,6-tetrahydropyridines with analgesic and hyperglycemic activity. Journal of Medicinal Chemistry. 25: 720-723. PMID 7097725 DOI: 10.1021/Jm00348A021 |
0.368 |
|
| 1982 |
Yeung JM, Corleto LA, Knaus EE. Synthesis of N-(carbonylamino)-1,2,3,6-tetrahydropyridines with analgesic, antiinflammatory, and hyperglycemic activity. Journal of Medicinal Chemistry. 25: 191-195. PMID 7057427 DOI: 10.1021/Jm00344A020 |
0.349 |
|
| 1982 |
Din MGE, Knaus EE, Giam C. Some reactions of 3-cyano(diethylaminocarbonyl, methoxycarbonyl) pyridines with organolithium reagents. Synthesis of stabilized 1,2-, 1,4-, and 1,6-dihydropyridines Canadian Journal of Chemistry. 60: 1821-1827. DOI: 10.1139/V82-251 |
0.35 |
|
| 1982 |
Krow GR, Carey JT, Zacharias DE, Knaus EE. Reexamination of stereochemical issues concerning 2-phenyl-1,2-dihydropyridine-maleimide cycloadditions Journal of Organic Chemistry. 47: 1989-1993. DOI: 10.1021/Jo00132A002 |
0.346 |
|
| 1982 |
Warren BK, Knaus EE. Some reactions of 1-methyl-1,2,3,4-tetrahydropyridine with organic azides. Synthesis of 1-methylpiperidylidene-2-sulfon(cyan)amides Journal of Heterocyclic Chemistry. 19: 1259-1260. DOI: 10.1002/Jhet.5570190562 |
0.322 |
|
| 1982 |
Yeung JM, Corleto LA, Knaus EE. Synthesis Of N-(((Substituted-Phenyl)Carbonyl)Amino)-1,2,3,6-Tetrahydropyridines With Analgesic And Hyperglycemic Activity Cheminform. 13. DOI: 10.1002/Chin.198246202 |
0.367 |
|
| 1982 |
Yeung JM, Corleto LA, Knaus EE. Synthesis Of N-(Carbonylamino)-1,2,3,6-Tetrahydropyridines With Analgesic, Antiinflammatory, And Hyperglycemic Activity Cheminform. 13. DOI: 10.1002/Chin.198227208 |
0.318 |
|
| 1981 |
Warren BK, Knaus EE. Some reactions of 1,4-dihydropyridines with organic azides. Synthesis of 2,7-diazabicyclo[4.1.0]hept-3-enes with analgesic and antiprotozoal activity. Journal of Medicinal Chemistry. 24: 462-464. PMID 7265132 DOI: 10.1021/Jm00136A017 |
0.368 |
|
| 1981 |
Abrams DN, Knaus EE, Wiebe LI, Helus F, Maier-Borst W. Tumour uptake of radiolabelled pyrimidine bases and pyrimidine nucleosides in animal models--IV. 2'-123I-iodo-2'-deoxyuridine. The International Journal of Applied Radiation and Isotopes. 32: 105-8. PMID 7203701 DOI: 10.1016/0020-708X(81)90142-3 |
0.554 |
|
| 1981 |
Mercer JR, Wiebe LI, Knaus EE. Synthesis of N-(4-pyridyl[14C]carbonylamino)-1,2,[3H]3,6-tetrahydropyridine and the mono-labelled [14C]- and [3H]-analogues Journal of Labelled Compounds and Radiopharmaceuticals. 18: 621-628. DOI: 10.1002/Jlcr.2580180503 |
0.569 |
|
| 1981 |
Avasthi K, Knaus EE. Synthesis and reactions of 1‐[1‐oxido‐2‐(3,4)‐pyridinyl]‐2‐methyloxiranes with nitrogen nucleophiles Journal of Heterocyclic Chemistry. 18: 375-382. DOI: 10.1002/Jhet.5570180230 |
0.375 |
|
| 1981 |
Warren BK, Knaus EE. Some Reactions Of 1,4-Dihydropyridines With Organic Azides. Synthesis Of 2,7-Diazabicyclo(4.1.0)Hept-3-Enes With Analgesic And Antiprotozoal Activity Cheminform. 12. DOI: 10.1002/Chin.198135264 |
0.3 |
|
| 1980 |
Knaus EE, Avasthi K, Giam CS. Diels–Alder cycloadditions of N-substituted-1,2-dihydropyridines with nitrosobenzene. Synthesis of 3-phenyl-2-oxa-3,6-diazabicyclo[2.2.2]oct-7-enes Canadian Journal of Chemistry. 58: 2447-2451. DOI: 10.1139/V80-394 |
0.385 |
|
| 1980 |
Knaus EE, Avasthi K, Redda K, Benderly A. Synthesis and reactions of 1-hydroxy-1-(pyridinyl)-2-propanones Canadian Journal of Chemistry. 58: 130-133. DOI: 10.1139/V80-020 |
0.339 |
|
| 1980 |
Knaus EE, Avasthi K, Redda K, Benderly A. Synthesis And Reactions Of 1-Hydroxy-1-(Pyridinyl)-2-Propanones Cheminform. 11. DOI: 10.1002/Chin.198023229 |
0.302 |
|
| 1980 |
Redda K, Corleto LA, Knaus EE. Syntheses Of N-Substituted 2(3,4)-Pyridylcarboxylic Acid Hydrazides With Analgesic And Antiinflammatory Activity Cheminform. 11. DOI: 10.1002/Chin.198005258 |
0.341 |
|
| 1980 |
Pasutto FM, Knaus EE. Some Reactions Of 10-Substituted-10H-Pyrido(3,2-B)(1,4)Benzothiazine-N-Butyllithium Adducts With Acyl And Sulfonyl Chlorides Cheminform. 11. DOI: 10.1002/Chin.198004272 |
0.334 |
|
| 1979 |
Abrams DN, Knaus EE, Wiebe LI. Tumor uptake of radiolabeled pyrimidine bases and pyrimidine nucleosides in animal models--I. 6-[3H]-5-fluorouracil. International Journal of Nuclear Medicine and Biology. 6: 97-101. PMID 478772 DOI: 10.1016/0047-0740(79)90003-2 |
0.516 |
|
| 1979 |
Redda K, Corleto LA, Knaus EE. Syntheses of N-substituted 2(3,4)-pyridylcarboxylic acid hydrazides with analgesic and antiinflammatory activity. Journal of Medicinal Chemistry. 22: 1079-1082. PMID 314983 DOI: 10.1021/Jm00195A013 |
0.394 |
|
| 1979 |
Lee YW, Knaus EE, Wiebe LI. Tumor uptake of radiolabeled pyrimidine bases and pyrimidine nucleosides in animal models--III. 2'-[82Br]-bromo-2'-deoxyuridine. International Journal of Nuclear Medicine and Biology. 6: 109-112. PMID 113355 DOI: 10.1016/0047-0740(79)90005-6 |
0.544 |
|
| 1979 |
Redda K, Corleto LA, Knaus EE. Quaternization and sodium borohydride reduction of N-(4-pyridylcarbonylamino)-1,2,3,6-tetrahydropyridine. Synthesis of N-amino-1,2,3,6-tetrahydropyridines Canadian Journal of Chemistry. 57: 2981-2985. DOI: 10.1139/V79-485 |
0.359 |
|
| 1979 |
Pasutto FM, Knaus EE. Some reactions of 10-substituted-10H-pyrido[3,2-b][1,4]benzothiazine-n-butyllithium adducts with acyl and sulfonyl chlorides Canadian Journal of Chemistry. 57: 2371-2378. DOI: 10.1139/V79-381 |
0.397 |
|
| 1979 |
Ondrus TA, Knaus EE, Ciam CS. Some reactions of 1,2‐dihydropyridines with cyanogen azide. Synthesis of üiazabieyclo[4.1.0]hept‐4‐enes Journal of Heterocyclic Chemistry. 16: 409-410. DOI: 10.1002/Jhet.5570160246 |
0.305 |
|
| 1978 |
Pasutto FM, Knaus EE. Some reactions of 10-methyl-10H-pyrido[3,2-b][1,4]benzothiazine-n-butyllithium adduct with electrophiles Canadian Journal of Chemistry. 56: 2365-2368. DOI: 10.1139/V78-387 |
0.35 |
|
| 1978 |
Ondrus TA, Pasutto FM, Knaus EE, Giam CS. Some reactions of 2-n-butyl(phenyl)-1,2-dihydropyridines with isocyanates, pyridyl esters, and diethyl chlorophosphate Canadian Journal of Chemistry. 56: 1913-1918. DOI: 10.1139/V78-311 |
0.344 |
|
| 1978 |
Ondrus TA, Knaus EE, Giam CS. Some reactions of N-substituted-1,2-dihydropyridines with cyanogen azide. Synthesis of 1,2,3,4-tetrahydropyridylidene-4-cyanamides Canadian Journal of Chemistry. 56: 1026-1030. DOI: 10.1139/V78-172 |
0.312 |
|
| 1978 |
Pasutto FM, Knaus EE. Some Reactions Of 10-Methyl-10H-Pyrido(3,2-B)(1,4)Benzothiazine-N-Butyllithium Adduct With Electrophiles Cheminform. 9. DOI: 10.1002/Chin.197849264 |
0.321 |
|
| 1978 |
Ondrus TA, Pasutto FM, Knaus EE, Giam CS. Some Reactions Of 2-Butyl(Phenyl)-1,2-Dihydropyridines With Isocyanates, Pyridyl Esters, And Diethyl Chlorophosphate Cheminform. 9. DOI: 10.1002/Chin.197845201 |
0.313 |
|
| 1978 |
Ondrus TA, Knaus EE, Giam CS. Some Reactions Of N-Substituted-1,2-Dihydropyridines With Cyanogen Azide. Synthesis Of 1,2,3,4-Tetrahydropyridylidene-4-Cyanamides Cheminform. 9. DOI: 10.1002/Chin.197832226 |
0.33 |
|
| 1977 |
Knaus EE, Redda K. The sodium borohydride reduction of N-sulfonylpyridinium salts. Synthesis of N-sulfonyl-1,4-(1,2-) dihydropyridines Canadian Journal of Chemistry. 55: 1788-1791. DOI: 10.1139/V77-251 |
0.341 |
|
| 1976 |
Knaus EE, Ondrus TA, Giam CS. Some reactions of 1‐lithio‐2‐n‐butyl‐1,2‐dihydropyridine. VI. Synthesis of β‐substituted pyridines Journal of Heterocyclic Chemistry. 13: 789-792. DOI: 10.1002/Jhet.5570130420 |
0.332 |
|
| 1976 |
Knaus EE, Pasutto FM, Giam CS, Swinyard EA. Diels‐alder cycloadditions of N‐substituted‐1,2‐dihydropyridines with 1,2,4‐triazoline‐3,5‐diones and maleimides Journal of Heterocyclic Chemistry. 13: 481-486. DOI: 10.1002/Jhet.5570130312 |
0.337 |
|
| 1974 |
Knaus EE, Pasutto FM, Giam CS. Diels-Alder Cycloadditions Of 1,2,4-Triazoline-3,5-Diones With N-Substituted-1,2-Dihydropyridines Journal of Heterocyclic Chemistry. 11: 843-844. DOI: 10.1002/Jhet.5570110539 |
0.315 |
|
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