Donald Poirier - Publications

Affiliations: 
Universite Laval (Canada) 
Area:
Pharmaceutical Chemistry

111 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Maltais R, Perreault M, Roy J, Poirier D. Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility. European Journal of Medicinal Chemistry. 188: 111990. PMID 31893547 DOI: 10.1016/j.ejmech.2019.111990  1
2019 Boutin S, Roy J, Maltais R, Poirier D. Formation of 5α-dihydrotestosterone from 5α-androstane-3α,17β-diol in prostate cancer LAPC-4 cells - Identifying inhibitors of non-classical pathways producing the most potent androgen. Bioorganic & Medicinal Chemistry Letters. 126783. PMID 31753699 DOI: 10.1016/j.bmcl.2019.126783  1
2019 Cortés-Benítez F, Roy J, Perreault M, Maltais R, Poirier D. A- and D-ring structural modifications of an androsterone derivative inhibiting 17β-hydroxysteroid dehydrogenase type 3: Chemical synthesis and structure-activity relationships. Journal of Medicinal Chemistry. PMID 31268309 DOI: 10.1021/acs.jmedchem.9b00624  1
2019 Poirier D, Roy J, Maltais R, Ayan D. Antisulfatase, osteogenic and anticancer activities of steroid sulfatase inhibitor EO-33 in mice. Journal of Medicinal Chemistry. PMID 31062594 DOI: 10.1021/acs.jmedchem.9b00382  1
2018 Sancéau JY, Maltais R, Poirier D, Marette A. Total Synthesis of the Antidiabetic (Type 2) Lipid Mediator Protectin DX/PDX. The Journal of Organic Chemistry. PMID 30586310 DOI: 10.1021/acs.joc.8b01973  1
2018 Boutin S, Roy J, Maltais R, Alata W, Calon F, Poirier D. Identification of steroidal derivatives inhibiting the transformations of allopregnanolone and estradiol by 17β-hydroxysteroid dehydrogenase type 10. Bioorganic & Medicinal Chemistry Letters. PMID 30297283 DOI: 10.1016/j.bmcl.2018.09.031  1
2018 Lespérance M, Barbeau X, Roy J, Maltais R, Lagüe P, Poirier D. Chemical Synthesis of C3-oxiranyl/oxiranylmethyl-estrane derivatives targeted by molecular modeling and tested as potential inhibitors of 17β-hydroxysteroid dehydrogenase type 1. Steroids. PMID 30273695 DOI: 10.1016/j.steroids.2018.09.009  1
2018 Dutour R, Roy J, Cortés-Benítez F, Maltais R, Poirier D. Targeting Cytochrome P450 (CYP) 1B1 Enzyme with Four Series of A-ring Substituted Estrane Derivatives: Design, Synthesis, Inhibitory Activity and Selectivity. Journal of Medicinal Chemistry. PMID 30216063 DOI: 10.1021/acs.jmedchem.8b00907  1
2018 Li T, Maltais R, Poirier D, Lin SX. Combined Biophysical Chemistry Reveals the Finding of a New Covalent Inhibitor with a Low-Reactive Alkyl Halide. The Journal of Physical Chemistry Letters. PMID 30148957 DOI: 10.1021/acs.jpclett.8b02225  1
2018 Perreault M, Maltais R, Roy J, Picard S, Popa I, Bertrand N, Poirier D. Induction of endoplasmic reticulum stress by aminosteroid derivative RM-581 leads to tumor regression in PANC-1 xenograft model. Investigational New Drugs. PMID 30062573 DOI: 10.1007/s10637-018-0643-4  1
2018 Sang X, Han H, Poirier D, Lin SX. Steroid sulfatase inhibition success and limitation in breast cancer clinical assays: an underlying mechanism. The Journal of Steroid Biochemistry and Molecular Biology. PMID 29803725 DOI: 10.1016/j.jsbmb.2018.05.009  0.44
2018 Dutour R, Maltais R, Perreault M, Roy J, Poirier D. Parallel Solid-Phase Synthesis Using a New Diethylsilylacetylenic Linker and Leading to Mestranol Derivatives with Potent Antiproliferative Activities on Multiple Cancer Cell Lines. Anti-Cancer Agents in Medicinal Chemistry. PMID 29521249 DOI: 10.2174/1871520618666180307130158  1
2017 Perreault M, Maltais R, Kenmogne LC, Létourneau D, LeHoux JG, Gobeil S, Poirier D. Implication of STARD5 and cholesterol homeostasis disturbance in the endoplasmic reticulum stress-related response induced by pro-apoptotic aminosteroid RM-133. Pharmacological Research. PMID 29287690 DOI: 10.1016/j.phrs.2017.12.024  1
2017 Maltais R, Trottier A, Roy J, Ayan D, Bertrand N, Poirier D. Pharmacokinetic profile of PBRM in rodents, a first selective covalent inhibitor of 17β-HSD1 for breast cancer and endometriosis treatments. The Journal of Steroid Biochemistry and Molecular Biology. PMID 29248731 DOI: 10.1016/j.jsbmb.2017.12.007  1
2017 Dutour R, Cortés-Benítez F, Roy J, Poirier D. Structure-Based Design and Synthesis of New Estrane-Pyridine Derivatives as Cytochrome P450 (CYP) 1B1 Inhibitors. Acs Medicinal Chemistry Letters. 8: 1159-1164. PMID 29152048 DOI: 10.1021/acsmedchemlett.7b00265  0.68
2017 Trottier A, Maltais R, Ayan D, Barbeau X, Roy J, Perreault M, Poulin R, Lagüe P, Poirier D. Insight into the mode of action and selectivity of PBRM, a covalent steroidal inhibitor of 17β-hydroxysteroid dehydrogenase type 1. Biochemical Pharmacology. PMID 28800957 DOI: 10.1016/j.bcp.2017.08.004  1
2017 Dutour R, Poirier D. Inhibitors of cytochrome P450 (CYP) 1B1. European Journal of Medicinal Chemistry. 135: 296-306. PMID 28458135 DOI: 10.1016/j.ejmech.2017.04.042  0.6
2017 Cortés-Benítez F, Roy J, Maltais R, Poirier D. Impact of androstane A- and D-ring inversion on 17β-hydroxysteroid dehydrogenase type 3 inhibitory activity, androgenic effect and metabolic stability. Bioorganic & Medicinal Chemistry. PMID 28254377 DOI: 10.1016/j.bmc.2017.02.008  1
2017 Kenmogne LC, Roy J, Maltais R, Rouleau M, Neveu B, Pouliot F, Poirier D. Investigation of the In Vitro and In Vivo efficiency of RM-532-105, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, in LAPC-4 prostate cancer cell and tumor models. Plos One. 12: e0171871. PMID 28182747 DOI: 10.1371/journal.pone.0171871  1
2017 Perreault M, Maltais R, Roy J, Dutour R, Poirier D. Design of a Mestranol 2-N-Piperazino-Substituted Derivative Showing Potent and Selective in vitro and in vivo Activities in MCF-7 Breast Cancer Models. Chemmedchem. PMID 28060448 DOI: 10.1002/cmdc.201600482  1
2016 Poirier D, Roy J, Cortés-Benítez F, Dutour R. Targeting cytochrome P450 (CYP) 1B1 with steroid derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 27687674 DOI: 10.1016/j.bmcl.2016.09.046  0.68
2016 Perreault M, Maltais R, Dutour R, Poirier D. Explorative study on the anticancer activity, selectivity and metabolic stability of related analogs of aminosteroid RM-133. Steroids. PMID 27553727 DOI: 10.1016/j.steroids.2016.08.015  1
2016 Ouellet C, Maltais R, Ouellet É, Barbeau X, Lagüe P, Poirier D. Discovery of a sulfamate-based steroid sulfatase inhibitor with intrinsic selective estrogen receptor modulator properties. European Journal of Medicinal Chemistry. 119: 169-182. PMID 27155470 DOI: 10.1016/j.ejmech.2016.04.044  1
2016 Kenmogne LC, Maltais R, Poirier D. Synthesis of a dansyl-labeled inhibitor of 17β-hydroxysteroid dehydrogenase type 3 for optical imaging. Bioorganic & Medicinal Chemistry Letters. 26: 2179-83. PMID 27025340 DOI: 10.1016/j.bmcl.2016.03.069  1
2015 Talbot A, Maltais R, Kenmogne LC, Roy J, Poirier D. Solid-phase synthesis of libraries of ethynylated aminosteroid derivatives as potential antileukemic agents. Steroids. PMID 26742630 DOI: 10.1016/j.steroids.2015.12.019  1
2015 Kenmogne LC, Ayan D, Roy J, Maltais R, Poirier D. The Aminosteroid Derivative RM-133 Shows In Vitro and In Vivo Antitumor Activity in Human Ovarian and Pancreatic Cancers. Plos One. 10: e0144890. PMID 26660672 DOI: 10.1371/journal.pone.0144890  1
2015 Maltais R, Trottier A, Barbeau X, Lagüe P, Perreault M, Thériault JF, Lin SX, Poirier D. Impact of structural modifications at positions 13, 16 and 17 of 16β-(m-carbamoylbenzyl)-estradiol on 17β-hydroxysteroid dehydrogenase type 1 inhibition and estrogenic activity. The Journal of Steroid Biochemistry and Molecular Biology. PMID 26519987 DOI: 10.1016/j.jsbmb.2015.10.020  1
2015 Roy J, Fournier MA, Maltais R, Kenmogne LC, Poirier D. Reprint of "In vitro and in vivo evaluation of a 3β-androsterone derivative as inhibitor of 17β-hydroxysteroid dehydrogenase type 3". The Journal of Steroid Biochemistry and Molecular Biology. 153: 170-8. PMID 26291835 DOI: 10.1016/j.jsbmb.2015.08.014  1
2015 Djigoué GB, Kenmogne LC, Roy J, Maltais R, Poirier D. Design, chemical synthesis and biological evaluation of 3-spiromorpholinone/3-spirocarbamate androsterone derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 3. Bioorganic & Medicinal Chemistry. 23: 5433-51. PMID 26277760 DOI: 10.1016/j.bmc.2015.07.049  1
2015 Mansour MF, Pelletier M, Boulet MM, Mayrand D, Brochu G, Lebel S, Poirier D, Fradette J, Cianflone K, Luu-The V, Tchernof A. Oxidative activity of 17β-hydroxysteroid dehydrogenase on testosterone in male abdominal adipose tissues and cellular localization of 17β-HSD type 2. Molecular and Cellular Endocrinology. PMID 26123590 DOI: 10.1016/j.mce.2015.06.016  1
2015 Wang X, Gérard C, Thériault JF, Poirier D, Doillon CJ, Lin SX. Synergistic control of sex hormones by 17β-HSD type 7: a novel target for estrogen-dependent breast cancer. Journal of Molecular Cell Biology. 7: 568-79. PMID 25966904 DOI: 10.1093/jmcb/mjv028  0.44
2015 Maltais R, Trottier A, Delhomme A, Barbeau X, Lagüe P, Poirier D. Identification of fused 16β,17β-oxazinone-estradiol derivatives as a new family of non-estrogenic 17β-hydroxysteroid dehydrogenase type 1 inhibitors. European Journal of Medicinal Chemistry. 93: 470-80. PMID 25728028 DOI: 10.1016/j.ejmech.2015.01.059  1
2015 Ouellet C, Ouellet É, Poirier D. In vitro evaluation of a tetrahydroisoquinoline derivative as a steroid sulfatase inhibitor and a selective estrogen receptor modulator. Investigational New Drugs. 33: 95-103. PMID 25410727 DOI: 10.1007/s10637-014-0187-1  1
2014 Ayan D, Maltais R, Hospital A, Poirier D. Chemical synthesis, cytotoxicity, selectivity and bioavailability of 5α-androstane-3α,17β-diol derivatives. Bioorganic & Medicinal Chemistry. 22: 5847-59. PMID 25300820 DOI: 10.1016/j.bmc.2014.09.026  1
2014 Djigoué GB, Maltais R, Poirier D. Development of a simple and efficient solution-phase parallel synthesis of flexible non-steroidal estradiol mimics. Combinatorial Chemistry & High Throughput Screening. 17: 734-44. PMID 25230027  1
2014 Trottier A, Maltais R, Poirier D. Identification of a first enzymatic activator of a 17β-hydroxysteroid dehydrogenase. Acs Chemical Biology. 9: 1668-73. PMID 24910887 DOI: 10.1021/cb500109e  1
2014 Maltais R, Hospital A, Delhomme A, Roy J, Poirier D. Chemical synthesis, NMR analysis and evaluation on a cancer xenograft model (HL-60) of the aminosteroid derivative RM-133. Steroids. 82: 68-76. PMID 24486462 DOI: 10.1016/j.steroids.2014.01.008  1
2014 Roy J, Fournier MA, Maltais R, Kenmogne LC, Poirier D. In vitro and in vivo evaluation of a 3β-androsterone derivative as inhibitor of 17β-hydroxysteroid dehydrogenase type 3. The Journal of Steroid Biochemistry and Molecular Biology. 141: 44-51. PMID 24434282 DOI: 10.1016/j.jsbmb.2013.12.019  1
2014 Maltais R, Ayan D, Trottier A, Barbeau X, Lagüe P, Bouchard JE, Poirier D. Discovery of a non-estrogenic irreversible inhibitor of 17β-hydroxysteroid dehydrogenase type 1 from 3-substituted-16β-(m-carbamoylbenzyl)-estradiol derivatives. Journal of Medicinal Chemistry. 57: 204-22. PMID 24328103 DOI: 10.1021/jm401639v  1
2013 Djigoué GB, Kenmogne LC, Roy J, Poirier D. Synthesis of 3-spiromorpholinone androsterone derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 3. Bioorganic & Medicinal Chemistry Letters. 23: 6360-2. PMID 24144853 DOI: 10.1016/j.bmcl.2013.09.072  0.84
2013 Poirier D. Synthesis and biological testing of steroid derivatives as inhibitors. The Journal of Steroid Biochemistry and Molecular Biology. 137: 174-5. PMID 23851217 DOI: 10.1016/j.jsbmb.2013.07.003  1
2013 Roy J, Lefebvre J, Maltais R, Poirier D. Inhibition of dehydroepiandosterone sulfate action in androgen-sensitive tissues by EM-1913, an inhibitor of steroid sulfatase Molecular and Cellular Endocrinology. 376: 148-155. PMID 23806558 DOI: 10.1016/j.mce.2013.06.022  1
2013 Farhane S, Fournier MA, Poirier D. Chemical synthesis, characterisation and biological evaluation of lactonic-estradiol derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 1. The Journal of Steroid Biochemistry and Molecular Biology. 137: 322-31. PMID 23685015 DOI: 10.1016/j.jsbmb.2013.05.002  1
2013 Djigoué GB, Ngatcha BT, Roy J, Poirier D. Synthesis of 5α-androstane-17-spiro-δ-lactones with a 3-keto, 3-hydroxy, 3-spirocarbamate or 3-spiromorpholinone as inhibitors of 17β-hydroxysteroid dehydrogenases. Molecules (Basel, Switzerland). 18: 914-33. PMID 23344201 DOI: 10.3390/molecules18010914  0.72
2013 Ajeawung NF, Maltais R, Jones C, Poirier D, Kamnasaran D. Viability screen on pediatric low grade glioma cell lines unveils a novel anti-cancer drug of the steroid biosynthesis inhibitor family. Cancer Letters. 330: 96-105. PMID 23201138 DOI: 10.1016/j.canlet.2012.11.034  1
2012 Ayan D, Maltais R, Roy J, Poirier D. A new nonestrogenic steroidal inhibitor of 17β-hydroxysteroid dehydrogenase type I blocks the estrogen-dependent breast cancer tumor growth induced by estrone. Molecular Cancer Therapeutics. 11: 2096-104. PMID 22914440 DOI: 10.1158/1535-7163.MCT-12-0299  1
2012 Jegham H, Maltais R, Dufour P, Roy J, Poirier D. Solid-phase chemical synthesis and in vitro biological evaluation of novel 2β-piperazino-(20R)-5α-pregnane-3α,20-diol N-derivatives as anti-leukemic agents. Steroids. 77: 1403-18. PMID 22910290 DOI: 10.1016/j.steroids.2012.07.012  1
2012 Ayan D, Maltais R, Poirier D. Identification of a 17β-hydroxysteroid dehydrogenase type 10 steroidal inhibitor: a tool to investigate the role of type 10 in Alzheimer's disease and prostate cancer. Chemmedchem. 7: 1181-4. PMID 22674910 DOI: 10.1002/cmdc.201200129  1
2012 Djigoue GB, Simard M, Kenmogne LC, Poirier D. Two androsterone derivatives as inhibitors of androgen biosynthesis. Acta Crystallographica. Section C, Crystal Structure Communications. 68: o231-4. PMID 22669194 DOI: 10.1107/S0108270112021099  0.84
2012 Talbot A, Maltais R, Poirier D. New diethylsilylacetylenic linker for parallel solid-phase synthesis of libraries of hydroxy acetylenic steroid derivatives with improved metabolic stability. Acs Combinatorial Science. 14: 347-51. PMID 22587990 DOI: 10.1021/co300034y  1
2012 Gauthier J, Poirier D, Ayotte C. Characterization of desoxymethyltestosterone main urinary metabolite produced from cultures of human fresh hepatocytes. Steroids. 77: 635-43. PMID 22366110 DOI: 10.1016/j.steroids.2012.02.008  1
2012 Jegham H, Maltais R, Roy J, Doillon C, Poirier D. Biological evaluation of a new family of aminosteroids that display a selective toxicity for various malignant cell lines. Anti-Cancer Drugs. 23: 803-14. PMID 22361842 DOI: 10.1097/CAD.0b013e328351aa8c  1
2012 Jegham H, Roy J, Maltais R, Desnoyers S, Poirier D. A novel aminosteroid of the 5α-androstane-3α,17β-diol family induces cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells. Investigational New Drugs. 30: 176-85. PMID 20890632 DOI: 10.1007/s10637-010-9548-6  1
2011 Maltais R, Ayan D, Poirier D. Crucial Role of 3-Bromoethyl in Removing the Estrogenic Activity of 17β-HSD1 Inhibitor 16β-(m-Carbamoylbenzyl)estradiol. Acs Medicinal Chemistry Letters. 2: 678-681. PMID 21927646 DOI: 10.1021/ml200093v  1
2011 Ayan D, Roy J, Maltais R, Poirier D. Impact of estradiol structural modifications (18-methyl and/or 17-hydroxy inversion of configuration) on the in vitro and in vivo estrogenic activity. The Journal of Steroid Biochemistry and Molecular Biology. 127: 324-30. PMID 21827856 DOI: 10.1016/j.jsbmb.2011.07.009  1
2011 Ouellet E, Ayan D, Poirier D. Synthesis and preliminary evaluation of a modified estradiol-core bearing a fused γ-lactone as non-estrogenic inhibitor of 17β-hydroxysteroid dehydrogenase type 1. Bioorganic & Medicinal Chemistry Letters. 21: 5510-3. PMID 21782424 DOI: 10.1016/j.bmcl.2011.06.110  1
2011 Fournier D, Poirier D. Chemical synthesis and evaluation of 17α-alkylated derivatives of estradiol as inhibitors of steroid sulfatase. European Journal of Medicinal Chemistry. 46: 4227-37. PMID 21782294 DOI: 10.1016/j.ejmech.2011.06.027  1
2011 Maltais R, Fournier MA, Poirier D. Development of 3-substituted-androsterone derivatives as potent inhibitors of 17β-hydroxysteroid dehydrogenase type 3. Bioorganic & Medicinal Chemistry. 19: 4652-68. PMID 21741247 DOI: 10.1016/j.bmc.2011.06.003  1
2011 Maltais R, Poirier D. Steroid sulfatase inhibitors: a review covering the promising 2000-2010 decade. Steroids. 76: 929-48. PMID 21458474 DOI: 10.1016/j.steroids.2011.03.010  1
2011 Farhane S, Laplante Y, Poirier D. Chemical synthesis, characterisation and biological evaluation of furanic-estradiol derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 1. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 7: 80-91. PMID 21222612  1
2011 Poirier D. Contribution to the development of inhibitors of 17β-hydroxysteroid dehydrogenase types 1 and 7: key tools for studying and treating estrogen-dependent diseases. The Journal of Steroid Biochemistry and Molecular Biology. 125: 83-94. PMID 21182944 DOI: 10.1016/j.jsbmb.2010.12.007  1
2011 Roy J, Maltais R, Jegham H, Poirier D. Libraries of 2β-(N-substituted piperazino)-5α-androstane-3α, 17β-diols: chemical synthesis and cytotoxic effects on human leukemia HL-60 cells and on normal lymphocytes. Molecular Diversity. 15: 317-39. PMID 20827507 DOI: 10.1007/s11030-010-9273-2  1
2010 Poirier D. 17beta-Hydroxysteroid dehydrogenase inhibitors: a patent review. Expert Opinion On Therapeutic Patents. 20: 1123-45. PMID 20645882 DOI: 10.1517/13543776.2010.505604  1
2010 Lin SX, Chen J, Mazumdar M, Poirier D, Wang C, Azzi A, Zhou M. Molecular therapy of breast cancer: progress and future directions. Nature Reviews. Endocrinology. 6: 485-93. PMID 20644568 DOI: 10.1038/nrendo.2010.92  0.44
2010 Bérubé M, Delagoutte F, Poirier D. Preparation of 6beta-estradiol derivative libraries as bisubstrate inhibitors of 7beta-hydroxysteroid dehydrogenase type using the multidetachable sulfamate linker. Molecules (Basel, Switzerland). 15: 1590-631. PMID 20336003 DOI: 10.3390/molecules15031590  1
2010 Aka JA, Mazumdar M, Chen CQ, Poirier D, Lin SX. 17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production. Molecular Endocrinology (Baltimore, Md.). 24: 832-45. PMID 20172961 DOI: 10.1210/me.2009-0468  0.44
2009 Mazumdar M, Fournier D, Zhu DW, Cadot C, Poirier D, Lin SX. Binary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy. The Biochemical Journal. 424: 357-66. PMID 19929851 DOI: 10.1042/BJ20091020  0.44
2009 Bellavance E, Luu-The V, Poirier D. Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone. Journal of Medicinal Chemistry. 52: 7488-502. PMID 19772289 DOI: 10.1021/jm900921c  1
2009 Poirier D. Advances in development of inhibitors of 17beta hydroxysteroid dehydrogenases. Anti-Cancer Agents in Medicinal Chemistry. 9: 642-60. PMID 19601747  1
2009 Hojo Y, Higo S, Ishii H, Ooishi Y, Mukai H, Murakami G, Kominami T, Kimoto T, Honma S, Poirier D, Kawato S. Comparison between hippocampus-synthesized and circulation-derived sex steroids in the hippocampus. Endocrinology. 150: 5106-12. PMID 19589866 DOI: 10.1210/en.2009-0305  1
2009 Higo S, Hojo Y, Ishii H, Kominami T, Nakajima K, Poirier D, Kimoto T, Kawato S. Comparison of sex-steroid synthesis between neonatal and adult rat hippocampus. Biochemical and Biophysical Research Communications. 385: 62-6. PMID 19426711 DOI: 10.1016/j.bbrc.2009.05.005  1
2009 Fournier D, Breuil PA, Poirier D. Synthesis of aryl sulfamate and phenol small peptide derivatives using a multidetachable sulfamate linker strategy. Advances in Experimental Medicine and Biology. 611: 219-20. PMID 19400168 DOI: 10.1007/978-0-387-73657-0_101  1
2009 Fournier D, Poirier D. Estradiol dimers as a new class of steroid sulfatase reversible inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 693-6. PMID 19128967 DOI: 10.1016/j.bmcl.2008.12.047  1
2009 Bérubé M, Poirier D. Improved synthesis of EM-1745, preparation of its C17-ketone analogue and comparison of their inhibitory potency on 17beta-hydroxysteroid dehydrogenase type 1. Journal of Enzyme Inhibition and Medicinal Chemistry. 24: 832-43. PMID 19003559 DOI: 10.1080/14756360802399761  1
2009 Fournier MA, Poirier D. Estrogen formation in endometrial and cervix cancer cell lines: involvement of aromatase, steroid sulfatase and 17beta-hydroxysteroid dehydrogenases (types 1, 5, 7 and 12). Molecular and Cellular Endocrinology. 301: 142-5. PMID 18817841 DOI: 10.1016/j.mce.2008.08.027  1
2009 Laplante Y, Rancourt C, Poirier D. Relative involvement of three 17beta-hydroxysteroid dehydrogenases (types 1, 7 and 12) in the formation of estradiol in various breast cancer cell lines using selective inhibitors. Molecular and Cellular Endocrinology. 301: 146-53. PMID 18812208 DOI: 10.1016/j.mce.2008.08.026  1
2009 Chura JC, Ryu HS, Simard M, Poirier D, Tremblay Y, Brooker DC, Blomquist CH, Argenta PA. Steroid-converting enzymes in human ovarian carcinomas. Molecular and Cellular Endocrinology. 301: 51-8. PMID 18723074 DOI: 10.1016/j.mce.2008.07.015  0.4
2009 Bydal P, Luu-The V, Labrie F, Poirier D. Steroidal lactones as inhibitors of 17beta-hydroxysteroid dehydrogenase type 5: chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities. European Journal of Medicinal Chemistry. 44: 632-44. PMID 18472187 DOI: 10.1016/j.ejmech.2008.03.020  0.6
2008 Gulea A, Poirier D, Roy J, Stavila V, Bulimestru I, Tapcov V, Birca M, Popovschi L. In vitro antileukemia, antibacterial and antifungal activities of some 3d metal complexes: chemical synthesis and structure - activity relationships. Journal of Enzyme Inhibition and Medicinal Chemistry. 23: 806-18. PMID 18618364 DOI: 10.1080/14756360701743002  0.68
2008 Thibeault D, Roy J, DeRoy P, Poirier D. Chemical synthesis of 2beta-amino-5alpha-androstane-3alpha,17beta-diol N-derivatives and their antiproliferative effect on HL-60 human leukemia cells. Bioorganic & Medicinal Chemistry. 16: 5062-77. PMID 18375126 DOI: 10.1016/j.bmc.2008.03.031  0.68
2008 Laplante Y, Poirier D. Proliferative effect of androst-4-ene-3,17-dione and its metabolites in the androgen-sensitive LNCaP cell line. Steroids. 73: 266-71. PMID 18082864 DOI: 10.1016/j.steroids.2007.10.009  1
2008 Laplante Y, Cadot C, Fournier MA, Poirier D. Estradiol and estrone C-16 derivatives as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: blocking of ER+ breast cancer cell proliferation induced by estrone. Bioorganic & Medicinal Chemistry. 16: 1849-60. PMID 18035543 DOI: 10.1016/j.bmc.2007.11.007  0.64
2007 Bérubé M, Poirier D. Chemical synthesis and in vitro biological evaluation of a phosphorylated bisubstrate inhibitor of type 3 17beta-hydroxysteroid dehydrogenase. Journal of Enzyme Inhibition and Medicinal Chemistry. 22: 201-11. PMID 17518347 DOI: 10.1080/14756360601051423  1
2007 Roy J, DeRoy P, Poirier D. 2beta-(N-substituted piperazino)-5alpha-androstane-3alpha,17beta-diols: parallel solid-phase synthesis and antiproliferative activity on human leukemia HL-60 cells. Journal of Combinatorial Chemistry. 9: 347-58. PMID 17441773 DOI: 10.1021/cc060098z  1
2007 Roy J, Breton R, Martel C, Labrie F, Poirier D. Chemical synthesis and biological activities of 16alpha-derivatives of 5alpha-androstane-3alpha,17beta-diol as antiandrogens. Bioorganic & Medicinal Chemistry. 15: 3003-18. PMID 17336533 DOI: 10.1016/j.bmc.2007.02.007  0.68
2007 Cadot C, Laplante Y, Kamal F, Luu-The V, Poirier D. C6-(N,N-butyl-methyl-heptanamide) derivatives of estrone and estradiol as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: Chemical synthesis and biological evaluation. Bioorganic & Medicinal Chemistry. 15: 714-26. PMID 17110114 DOI: 10.1016/j.bmc.2006.10.055  1
2006 Ciobanu LC, Poirier D. Synthesis of libraries of 16beta-aminopropyl estradiol derivatives for targeting two key steroidogenic enzymes. Chemmedchem. 1: 1249-59. PMID 16986200 DOI: 10.1002/cmdc.200600071  1
2006 Bérubé M, Laplante Y, Poirier D. Design, synthesis and in vitro evaluation of 4-androstene-3,17-dione/adenosine hybrid compounds as bisubstrate inhibitors of type 3 17beta-hydroxysteroid dehydrogenase. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 2: 329-47. PMID 16848745 DOI: 10.2174/157340606777724086  1
2006 Couse JF, Yates MM, Rodriguez KF, Johnson JA, Poirier D, Korach KS. The intraovarian actions of estrogen receptor-alpha are necessary to repress the formation of morphological and functional Leydig-like cells in the female gonad. Endocrinology. 147: 3666-78. PMID 16627580 DOI: 10.1210/en.2006-0276  1
2006 Poirier D, Maltais R. Solid-phase organic synthesis (SPOS) of modulators of estrogenic and androgenic action. Mini Reviews in Medicinal Chemistry. 6: 37-52. PMID 16457631 DOI: 10.2174/138955706775197802  1
2006 Ngatcha BT, Laplante Y, Labrie F, Luu-The V, Poirier D. 3Beta-alkyl-androsterones as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase: inhibitory potency in intact cells, selectivity towards isoforms 1, 2, 5 and 7, binding affinity for steroid receptors, and proliferative/antiproliferative activities on AR+ and ER+ cell lines. Molecular and Cellular Endocrinology. 248: 225-32. PMID 16359782 DOI: 10.1016/j.mce.2005.10.023  0.6
2006 Poirier D, Chang HJ, Azzi A, Boivin RP, Lin SX. Estrone and estradiol C-16 derivatives as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase. Molecular and Cellular Endocrinology. 248: 236-8. PMID 16337735 DOI: 10.1016/j.mce.2005.10.017  0.56
2005 Poirier D, Boivin RP, Tremblay MR, Bérubé M, Qiu W, Lin SX. Estradiol-adenosine hybrid compounds designed to inhibit type 1 17beta-hydroxysteroid dehydrogenase. Journal of Medicinal Chemistry. 48: 8134-47. PMID 16366595 DOI: 10.1021/jm058235e  0.6
2005 Tchédam Ngatcha B, Luu-The V, Labrie F, Poirier D. Androsterone 3alpha-ether-3beta-substituted and androsterone 3beta-substituted derivatives as inhibitors of type 3 17beta-hydroxysteroid dehydrogenase: chemical synthesis and structure-activity relationship. Journal of Medicinal Chemistry. 48: 5257-68. PMID 16078844 DOI: 10.1021/jm058179h  0.6
2005 Tremblay MR, Boivin RP, Luu-The V, Poirier D. Inhibitors of type 1 17beta-hydroxysteroid dehydrogenase with reduced estrogenic activity: modifications of the positions 3 and 6 of estradiol. Journal of Enzyme Inhibition and Medicinal Chemistry. 20: 153-63. PMID 15968820 DOI: 10.1080/14756360500043307  0.6
2005 Maltais R, Mercier C, Labrie F, Poirier D. Solid-phase synthesis of model libraries of 3alpha,17beta-dihydroxy-16alpha-(aminoethyl-N-substituted)-5alpha-androstanes for the development of steroidal therapeutic agents. Molecular Diversity. 9: 67-79. PMID 15789554  1
2004 Bérubé M, Poirier D. Synthesis of simplified hybrid inhibitors of type 1 17beta-hydroxysteroid dehydrogenase via cross-metathesis and sonogashira coupling Reactions. Organic Letters. 6: 3127-30. PMID 15330604 DOI: 10.1021/ol048820u  1
2004 Maltais R, Tremblay MR, Ciobanu LC, Poirier D. Steroids and combinatorial chemistry. Journal of Combinatorial Chemistry. 6: 443-56. PMID 15244402 DOI: 10.1021/cc030118m  1
2004 Bydal P, Auger S, Poirier D. Inhibition of type 2 17beta-hydroxysteroid dehydrogenase by estradiol derivatives bearing a lactone on the D-ring: structure-activity relationships. Steroids. 69: 325-42. PMID 15219411 DOI: 10.1016/j.steroids.2004.03.002  1
2003 Ciobanu LC, Luu-The V, Martel C, Labrie F, Poirier D. Inhibition of estrone sulfate-induced uterine growth by potent nonestrogenic steroidal inhibitors of steroid sulfatase. Cancer Research. 63: 6442-6. PMID 14559834  1
2003 Ciobanu LC, Poirier D. Solid-phase parallel synthesis of 17alpha-substituted estradiol sulfamate and phenol libraries using the multidetachable sulfamate linker. Journal of Combinatorial Chemistry. 5: 429-40. PMID 12857111 DOI: 10.1021/cc020115u  1
2003 Ciobanu LC, Boivin RP, Luu-The V, Poirier D. 3Beta-sulfamate derivatives of C19 and C21 steroids bearing a t-butylbenzyl or a benzyl group: synthesis and evaluation as non-estrogenic and non-androgenic steroid sulfatase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 18: 15-26. PMID 12751816 DOI: 10.1080/1475636031000069282  0.96
2003 Poirier D. Inhibitors of 17 beta-hydroxysteroid dehydrogenases. Current Medicinal Chemistry. 10: 453-77. PMID 12570693  1
2002 Tchédam-Ngatcha B, Luu-The V, Poirier D. Androsterone derivatives substituted at position 16: chemical synthesis, inhibition of type 3 17beta-hydroxysteroid dehydrogenase, binding affinity for steroid receptors and proliferative/antiproliferative activity on Shionogi (AR+) cells. Journal of Enzyme Inhibition and Medicinal Chemistry. 17: 155-65. PMID 12443041 DOI: 10.1080/1475636021000002067  1
2002 Poirier D, Ciobanu LC, Bérubé M. A multidetachable sulfamate linker successfully used in a solid-phase strategy to generate libraries of sulfamate and phenol derivatives. Bioorganic & Medicinal Chemistry Letters. 12: 2833-8. PMID 12270157 DOI: 10.1016/S0960-894X(02)00637-6  1
2002 Qiu W, Campbell RL, Gangloff A, Dupuis P, Boivin RP, Tremblay MR, Poirier D, Lin SX. A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 1829-31. PMID 12223444 DOI: 10.1096/fj.02-0026fje  0.6
2002 Ciobanu LC, Luu-The V, Poirier D. Nonsteroidal compounds designed to mimic potent steroid sulfatase inhibitors. The Journal of Steroid Biochemistry and Molecular Biology. 80: 339-53. PMID 11948019 DOI: 10.1016/S0960-0760(02)00024-9  1
2002 Maltais R, Luu-The V, Poirier D. Synthesis and optimization of a new family of type 3 17 beta-hydroxysteroid dehydrogenase inhibitors by parallel liquid-phase chemistry. Journal of Medicinal Chemistry. 45: 640-53. PMID 11806715 DOI: 10.1021/jm010286y  1
2001 Ciobanu LC, Boivin RP, Luu-The V, Poirier D. Synthesis and steroid sulphatase inhibitory activity of C19- and C21-steroidal derivatives bearing a benzyl-inhibiting group. European Journal of Medicinal Chemistry. 36: 659-71. PMID 11600235  0.96
2000 Ciobanu LC, Maltais R, Poirier D. The sulfamate functional group as a new anchor for solid-phase organic synthesis Organic Letters. 2: 445-8. PMID 10814347  1
1999 Ciobanu LC, Boivin RP, Luu-The V, Labrie F, Poirier D. Potent inhibition of steroid sulfatase activity by 3-O-sulfamate 17alpha-benzyl(or 4'-tert-butylbenzyl)estra-1,3,5(10)-trienes: combination of two substituents at positions C3 and c17alpha of estradiol. Journal of Medicinal Chemistry. 42: 2280-6. PMID 10377235 DOI: 10.1021/jm980677l  0.96
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