David W. Litchfield - Publications

The University of Western Ontario (Canada) 
Cell Biology, Biochemistry, Molecular Biology

123 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Gyenis L, Menyhart D, Cruise ES, Jurcic K, Roffey SE, Chai DB, Trifoi F, Fess SR, Desormeaux PJ, Núñez de Villavicencio Díaz T, Rabalski AJ, Zukowski SA, Turowec JP, Pittock P, Lajoie G, ... Litchfield DW, et al. Chemical Genetic Validation of CSNK2 Substrates Using an Inhibitor-Resistant Mutant in Combination with Triple SILAC Quantitative Phosphoproteomics. Frontiers in Molecular Biosciences. 9: 909711. PMID 35755813 DOI: 10.3389/fmolb.2022.909711  0.512
2021 Strum SW, Gyenis L, Litchfield DW. CSNK2 in cancer: pathophysiology and translational applications. British Journal of Cancer. PMID 34773100 DOI: 10.1038/s41416-021-01616-2  0.342
2021 Roffey SE, Litchfield DW. CK2 Regulation: Perspectives in 2021. Biomedicines. 9. PMID 34680478 DOI: 10.3390/biomedicines9101361  0.525
2021 Wells CI, Drewry DH, Pickett JE, Tjaden A, Krämer A, Müller S, Gyenis L, Menyhart D, Litchfield DW, Knapp S, Axtman AD. Development of a potent and selective chemical probe for the pleiotropic kinase CK2. Cell Chemical Biology. PMID 33484635 DOI: 10.1016/j.chembiol.2020.12.013  0.374
2021 Nouri-Nejad D, O'Donnell BL, Patil CS, Sanchez-Pupo RE, Johnston D, Sayedyahossein S, Jurcic K, Lau R, Gyenis L, Litchfield DW, Jackson MF, Gloor GB, Penuela S. Pannexin 1 mutation found in melanoma tumour reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein. Molecular Biology of the Cell. mbcE19100585. PMID 33405952 DOI: 10.1091/mbc.E19-10-0585  0.401
2020 Strum S, Gyenis L, Litchfield DW. CSNK2 in cancer: Pathophysiology and translational applications. Journal of Clinical Oncology. 38: e15594-e15594. DOI: 10.1200/Jco.2020.38.15_Suppl.E15594  0.417
2019 Lefebvre C, Litchfield D, Allan A. Abstract 1282: Understanding the kinomic contributions to tyrosine kinase inhibitor resistance in triple negative breast cancer Cancer Research. 79: 1282-1282. DOI: 10.1158/1538-7445.Am2019-1282  0.463
2018 Bowie LE, Maiuri T, Alpaugh M, Gabriel M, Arbez N, Galleguillos D, Hung CLK, Patel S, Xia J, Hertz NT, Ross CA, Litchfield DW, Sipione S, Truant R. N6-Furfuryladenine is protective in Huntington's disease models by signaling huntingtin phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. PMID 29987005 DOI: 10.1073/Pnas.1801772115  0.415
2017 Kravic B, Harbauer AB, Romanello V, Simeone L, Vögtle FN, Kaiser T, Straubinger M, Huraskin D, Böttcher M, Cerqua C, Martin ED, Poveda-Huertes D, Buttgereit A, Rabalski AJ, Heuss D, ... ... Litchfield D, et al. In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy. Autophagy. 1-65. PMID 29165030 DOI: 10.1080/15548627.2017.1403716  0.398
2017 Münzer P, Walker-Allgaier B, Geue S, Langhauser F, Geuss E, Stegner D, Aurbach K, Semeniak D, Chatterjee M, Gonzalez Menendez I, Märklin M, Quintanilla-Martinez L, Salih HR, Litchfield DW, Buchou T, et al. CK2β critically regulates thrombopoiesis and Ca(2+)-triggered platelet activation in arterial thrombosis in vivo. Blood. PMID 28928125 DOI: 10.1182/Blood-2017-05-784413  0.308
2017 Okumu DO, East MP, Levine M, Herring LE, Zhang R, Gilbert TSK, Litchfield DW, Zhang Y, Graves LM. BIRC6 mediates imatinib resistance independently of Mcl-1. Plos One. 12: e0177871. PMID 28520795 DOI: 10.1371/Journal.Pone.0177871  0.492
2017 Nuñez de Villavicencio-Diaz T, Rabalski AJ, Litchfield DW. Protein Kinase CK2: Intricate Relationships within Regulatory Cellular Networks. Pharmaceuticals (Basel, Switzerland). 10. PMID 28273877 DOI: 10.3390/Ph10010027  0.55
2017 Borst O, Muenzer P, Walker-Allgaier B, Geue S, Langhauser F, Geuss E, Semeniak D, Litchfield D, Buchou T, Kleinschnitz C, Lang F, Schulze H, Gawaz M. 3132Casein Kinase 2 is a critical regulator of platelet Ca2+ signaling and activation in arterial thrombosis European Heart Journal. 38. DOI: 10.1093/Eurheartj/Ehx504.3132  0.381
2016 Bian Y, Li L, Dong M, Liu X, Kaneko T, Cheng K, Liu H, Voss C, Cao X, Wang Y, Litchfield D, Ye M, Li SS, Zou H. Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder. Nature Chemical Biology. PMID 27642862 DOI: 10.1038/Nchembio.2178  0.583
2016 Rabalski AJ, Gyenis L, Litchfield DW. Molecular Pathways: Emergence of Protein Kinase CK2 (CSNK2) as a Potential Target to Inhibit Survival and DNA Damage Response and Repair Pathways in Cancer Cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 22: 2840-7. PMID 27306791 DOI: 10.1158/1078-0432.Ccr-15-1314  0.512
2016 Gandin V, Masvidal L, Cargnello M, Gyenis L, McLaughlan S, Cai Y, Tenkerian C, Morita M, Balanathan P, Jean-Jean O, Stambolic V, Trost M, Furic L, Larose L, Koromilas AE, ... ... Litchfield D, et al. mTORC1 and CK2 coordinate ternary and eIF4F complex assembly. Nature Communications. 7: 11127. PMID 27040916 DOI: 10.1038/Ncomms11127  0.491
2016 Hermosilla V, Rabalski A, Gyenis L, Litchfield DW, Pincheira R. Abstract A39: Sall2 tumor suppressor protein is a novel Casein Kinase 2 target Cancer Research. 76. DOI: 10.1158/1538-7445.Fbcr15-A39  0.581
2015 Gamper I, Fleck D, Barlin M, Spehr M, El Sayad S, Kleine H, Maxeiner S, Schalla C, Aydin G, Hoss M, Litchfield DW, Lüscher B, Zenke M, Sechi A. GAR22β regulates cell migration, sperm motility and axoneme structure. Molecular Biology of the Cell. PMID 26564797 DOI: 10.1091/Mbc.E15-06-0426  0.424
2015 Dick SA, Chang NC, Dumont NA, Bell RA, Putinski C, Kawabe Y, Litchfield DW, Rudnicki MA, Megeney LA. Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 26372956 DOI: 10.1073/Pnas.1512869112  0.38
2015 Sohail M, Zhang M, Litchfield D, Wang L, Kung S, Xie J. Differential Expression, Distinct Localization and Opposite Effect on Golgi Structure and Cell Differentiation by a Novel Splice Variant of Human PRMT5. Biochimica Et Biophysica Acta. PMID 26151339 DOI: 10.1016/J.Bbamcr.2015.07.003  0.362
2015 Litchfield DW, Shilton BH, Brandl CJ, Gyenis L. Pin1: Intimate involvement with the regulatory protein kinase networks in the global phosphorylation landscape. Biochimica Et Biophysica Acta. 1850: 2077-86. PMID 25766872 DOI: 10.1016/J.Bbagen.2015.02.018  0.52
2015 Innes BT, Sowole MA, Gyenis L, Dubinsky M, Konermann L, Litchfield DW, Brandl CJ, Shilton BH. Peroxide-mediated oxidation and inhibition of the peptidyl-prolyl isomerase Pin1. Biochimica Et Biophysica Acta. 1852: 905-12. PMID 25595659 DOI: 10.1016/J.Bbadis.2014.12.025  0.334
2015 St-Denis N, Gabriel M, Turowec JP, Gloor GB, Li SS, Gingras AC, Litchfield DW. Systematic investigation of hierarchical phosphorylation by protein kinase CK2. Journal of Proteomics. 118: 49-62. PMID 25449829 DOI: 10.1016/J.Jprot.2014.10.020  0.615
2014 Turowec JP, Zukowski SA, Knight JD, Smalley DM, Graves LM, Johnson GL, Li SS, Lajoie GA, Litchfield DW. An unbiased proteomic screen reveals caspase cleavage is positively and negatively regulated by substrate phosphorylation. Molecular & Cellular Proteomics : McP. 13: 1184-97. PMID 24556848 DOI: 10.1074/Mcp.M113.037374  0.589
2014 Penuela S, Lohman AW, Lai W, Gyenis L, Litchfield DW, Isakson BE, Laird DW. Diverse post-translational modifications of the pannexin family of channel-forming proteins. Channels (Austin, Tex.). 8: 124-30. PMID 24418849 DOI: 10.4161/Chan.27422  0.359
2013 Estey MP, Di Ciano-Oliveira C, Froese CD, Fung KY, Steels JD, Litchfield DW, Trimble WS. Mitotic regulation of SEPT9 protein by cyclin-dependent kinase 1 (Cdk1) and Pin1 protein is important for the completion of cytokinesis. The Journal of Biological Chemistry. 288: 30075-86. PMID 23990466 DOI: 10.1074/Jbc.M113.474932  0.588
2013 Turowec JP, Vilk G, Gabriel M, Litchfield DW. Characterizing the convergence of protein kinase CK2 and caspase-3 reveals isoform-specific phosphorylation of caspase-3 by CK2α': implications for pathological roles of CK2 in promoting cancer cell survival. Oncotarget. 4: 560-71. PMID 23599180 DOI: 10.18632/Oncotarget.948  0.821
2013 Gyenis L, Turowec JP, Bretner M, Litchfield DW. Chemical proteomics and functional proteomics strategies for protein kinase inhibitor validation and protein kinase substrate identification: applications to protein kinase CK2. Biochimica Et Biophysica Acta. 1834: 1352-8. PMID 23416530 DOI: 10.1016/J.Bbapap.2013.02.006  0.562
2013 Innes BT, Bailey ML, Brandl CJ, Shilton BH, Litchfield DW. Non-catalytic participation of the Pin1 peptidyl-prolyl isomerase domain in target binding. Frontiers in Physiology. 4: 18. PMID 23407864 DOI: 10.3389/Fphys.2013.00018  0.441
2013 Gyenis L, Kuś A, Bretner M, Litchfield DW. Functional proteomics strategy for validation of protein kinase inhibitors reveals new targets for a TBB-derived inhibitor of protein kinase CK2. Journal of Proteomics. 81: 70-9. PMID 23017496 DOI: 10.1016/J.Jprot.2012.09.017  0.543
2012 Martić S, Beheshti S, Kraatz HB, Litchfield DW. Electrochemical investigations of Tau protein phosphorylations and interactions with Pin1. Chemistry & Biodiversity. 9: 1693-702. PMID 22976962 DOI: 10.1002/Cbdv.201100418  0.476
2012 Marti? S, Gabriel M, Turowec JP, Litchfield DW, Kraatz HB. Versatile strategy for biochemical, electrochemical and immunoarray detection of protein phosphorylations. Journal of the American Chemical Society. 134: 17036-45. PMID 22764889 DOI: 10.1021/Ja302586Q  0.552
2012 Penuela S, Gyenis L, Ablack A, Churko JM, Berger AC, Litchfield DW, Lewis JD, Laird DW. Loss of pannexin 1 attenuates melanoma progression by reversion to a melanocytic phenotype. The Journal of Biological Chemistry. 287: 29184-93. PMID 22753409 DOI: 10.1074/Jbc.M112.377176  0.351
2012 Kreutzer JN, Salvador A, Diana P, Cirrincione G, Vedaldi D, Litchfield DW, Issinger OG, Guerra B. 2-Triazenoazaindoles: α novel class of triazenes inducing transcriptional down-regulation of EGFR and HER-2 in human pancreatic cancer cells. International Journal of Oncology. 40: 914-22. PMID 22134789 DOI: 10.3892/Ijo.2011.1272  0.459
2012 Leung KK, Litchfield DW, Shilton BH. Flavin adenine dinucleotide content of quinone reductase 2: analysis and optimization for structure-function studies. Analytical Biochemistry. 420: 84-9. PMID 21971443 DOI: 10.1016/J.Ab.2011.09.011  0.331
2012 Duncan JS, Haystead TA, Litchfield DW. Chemoproteomic characterization of protein kinase inhibitors using immobilized ATP. Methods in Molecular Biology (Clifton, N.J.). 795: 119-34. PMID 21960219 DOI: 10.1007/978-1-61779-337-0_8  0.554
2012 Turowec JP, Duncan JS, Li S, Gloor G, Litchfield DW. Abstract 4970: Convergence of protein kinase and caspase signaling: A mechanism for pathological rewiring of survival pathways by protein kinase CK2 Cancer Research. 72: 4970-4970. DOI: 10.1158/1538-7445.Am2012-4970  0.604
2011 Gyenis L, Duncan JS, Turowec JP, Bretner M, Litchfield DW. Unbiased functional proteomics strategy for protein kinase inhibitor validation and identification of bona fide protein kinase substrates: application to identification of EEF1D as a substrate for CK2. Journal of Proteome Research. 10: 4887-901. PMID 21936567 DOI: 10.1021/Pr2008994  0.622
2011 Turowec JP, Duncan JS, Gloor GB, Litchfield DW. Regulation of caspase pathways by protein kinase CK2: identification of proteins with overlapping CK2 and caspase consensus motifs. Molecular and Cellular Biochemistry. 356: 159-67. PMID 21750976 DOI: 10.1007/S11010-011-0972-5  0.57
2011 Graves LM, Litchfield DW. "Going KiNativ": probing the Native Kinome. Chemistry & Biology. 18: 683-4. PMID 21700204 DOI: 10.1016/J.Chembiol.2011.06.001  0.454
2011 St-Denis NA, Bailey ML, Parker EL, Vilk G, Litchfield DW. Localization of phosphorylated CK2alpha to the mitotic spindle requires the peptidyl-prolyl isomerase Pin1. Journal of Cell Science. 124: 2341-8. PMID 21693590 DOI: 10.1242/Jcs.077446  0.809
2011 Duncan JS, Turowec JP, Duncan KE, Vilk G, Wu C, Lüscher B, Li SS, Gloor GB, Litchfield DW. A peptide-based target screen implicates the protein kinase CK2 in the global regulation of caspase signaling. Science Signaling. 4: ra30. PMID 21558555 DOI: 10.1126/Scisignal.2001682  0.8
2011 Zheng Y, Qin H, Frank SJ, Deng L, Litchfield DW, Tefferi A, Pardanani A, Lin FT, Li J, Sha B, Benveniste EN. A CK2-dependent mechanism for activation of the JAK-STAT signaling pathway. Blood. 118: 156-66. PMID 21527517 DOI: 10.1182/Blood-2010-01-266320  0.518
2011 Lukashova V, Szabó EZ, Jinadasa T, Mokhov A, Litchfield DW, Orlowski J. CK2 phosphorylation of an acidic Ser/Thr di-isoleucine motif in the Na+/H+ exchanger NHE5 isoform promotes association with beta-arrestin2 and endocytosis. The Journal of Biological Chemistry. 286: 11456-68. PMID 21296876 DOI: 10.1074/jbc.M110.182881  0.42
2011 Raaf J, Bischoff N, Klopffleisch K, Brunstein E, Olsen BB, Vilk G, Litchfield DW, Issinger OG, Niefind K. Interaction between CK2α and CK2β, the subunits of protein kinase CK2: thermodynamic contributions of key residues on the CK2α surface. Biochemistry. 50: 512-22. PMID 21142136 DOI: 10.1021/Bi1013563  0.787
2010 Turowec JP, Duncan JS, French AC, Gyenis L, St Denis NA, Vilk G, Litchfield DW. Protein kinase CK2 is a constitutively active enzyme that promotes cell survival: strategies to identify CK2 substrates and manipulate its activity in mammalian cells. Methods in Enzymology. 484: 471-93. PMID 21036246 DOI: 10.1016/B978-0-12-381298-8.00023-X  0.83
2010 Mani RS, Yu Y, Fang S, Lu M, Fanta M, Zolner AE, Tahbaz N, Ramsden DA, Litchfield DW, Lees-Miller SP, Weinfeld M. Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining. The Journal of Biological Chemistry. 285: 37619-29. PMID 20852255 DOI: 10.1074/Jbc.M109.058719  0.581
2010 Stendel C, Roos A, Kleine H, Arnaud E, Ozçelik M, Sidiropoulos PN, Zenker J, Schüpfer F, Lehmann U, Sobota RM, Litchfield DW, Lüscher B, Chrast R, Suter U, Senderek J. SH3TC2, a protein mutant in Charcot-Marie-Tooth neuropathy, links peripheral nerve myelination to endosomal recycling. Brain : a Journal of Neurology. 133: 2462-74. PMID 20826437 DOI: 10.1093/Brain/Awq168  0.309
2010 Bragdon B, Thinakaran S, Moseychuk O, King D, Young K, Litchfield DW, Petersen NO, Nohe A. Casein kinase 2 beta-subunit is a regulator of bone morphogenetic protein 2 signaling. Biophysical Journal. 99: 897-904. PMID 20682268 DOI: 10.1016/J.Bpj.2010.04.070  0.445
2010 Peters W, Willnow S, Duisken M, Kleine H, Macherey T, Duncan KE, Litchfield DW, Lüscher B, Weinhold E. Enzymatic site-specific functionalization of protein methyltransferase substrates with alkynes for click labeling. Angewandte Chemie (International Ed. in English). 49: 5170-3. PMID 20572224 DOI: 10.1002/Anie.201001240  0.366
2010 Hellwig CT, Ludwig-Galezowska AH, Concannon CG, Litchfield DW, Prehn JH, Rehm M. Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation. Journal of Cell Science. 123: 1401-6. PMID 20356928 DOI: 10.1242/jcs.061143  0.327
2010 Mohan RD, Litchfield DW, Torchia J, Tini M. Opposing regulatory roles of phosphorylation and acetylation in DNA mispair processing by thymine DNA glycosylase. Nucleic Acids Research. 38: 1135-48. PMID 19966277 DOI: 10.1093/Nar/Gkp1097  0.407
2010 Duncan JS, Turowec JP, Vilk G, Li SS, Gloor GB, Litchfield DW. Regulation of cell proliferation and survival: convergence of protein kinases and caspases. Biochimica Et Biophysica Acta. 1804: 505-10. PMID 19900592 DOI: 10.1016/J.Bbapap.2009.11.001  0.816
2009 Ji H, Wang J, Nika H, Hawke D, Keezer S, Ge Q, Fang B, Fang X, Fang D, Litchfield DW, Aldape K, Lu Z. EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin. Molecular Cell. 36: 547-59. PMID 19941816 DOI: 10.1016/J.Molcel.2009.09.034  0.417
2009 St-Denis NA, Litchfield DW. Protein kinase CK2 in health and disease: From birth to death: the role of protein kinase CK2 in the regulation of cell proliferation and survival. Cellular and Molecular Life Sciences : Cmls. 66: 1817-29. PMID 19387552 DOI: 10.1007/s00018-009-9150-2  0.51
2009 St-Denis NA, Derksen DR, Litchfield DW. Evidence for regulation of mitotic progression through temporal phosphorylation and dephosphorylation of CK2alpha. Molecular and Cellular Biology. 29: 2068-81. PMID 19188443 DOI: 10.1128/Mcb.01563-08  0.624
2009 Lahiry P, Wang J, Robinson JF, Turowec JP, Litchfield DW, Lanktree MB, Gloor GB, Puffenberger EG, Strauss KA, Martens MB, Ramsay DA, Rupar CA, Siu V, Hegele RA. A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems. American Journal of Human Genetics. 84: 134-47. PMID 19185282 DOI: 10.1016/J.Ajhg.2008.12.017  0.448
2008 Kerman K, Song H, Duncan JS, Litchfield DW, Kraatz HB. Peptide biosensors for the electrochemical measurement of protein kinase activity. Analytical Chemistry. 80: 9395-401. PMID 18989981 DOI: 10.1021/Ac801208E  0.563
2008 Kleine H, Poreba E, Lesniewicz K, Hassa PO, Hottiger MO, Litchfield DW, Shilton BH, Lüscher B. Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation. Molecular Cell. 32: 57-69. PMID 18851833 DOI: 10.1016/J.Molcel.2008.08.009  0.362
2008 Bailey ML, Shilton BH, Brandl CJ, Litchfield DW. The dual histidine motif in the active site of Pin1 has a structural rather than catalytic role. Biochemistry. 47: 11481-9. PMID 18844375 DOI: 10.1021/Bi800964Q  0.343
2008 Vilk G, Weber JE, Turowec JP, Duncan JS, Wu C, Derksen DR, Zien P, Sarno S, Donella-Deana A, Lajoie G, Pinna LA, Li SS, Litchfield DW. Protein kinase CK2 catalyzes tyrosine phosphorylation in mammalian cells. Cellular Signalling. 20: 1942-51. PMID 18662771 DOI: 10.1016/J.Cellsig.2008.07.002  0.835
2008 Sarker R, Grønborg M, Cha B, Mohan S, Chen Y, Pandey A, Litchfield D, Donowitz M, Li X. Casein kinase 2 binds to the C terminus of Na+/H+ exchanger 3 (NHE3) and stimulates NHE3 basal activity by phosphorylating a separate site in NHE3. Molecular Biology of the Cell. 19: 3859-70. PMID 18614797 DOI: 10.1091/Mbc.E08-01-0019  0.546
2008 Gyenis L, Litchfield DW. The emerging CK2 interactome: insights into the regulation and functions of CK2. Molecular and Cellular Biochemistry. 316: 5-14. PMID 18553055 DOI: 10.1007/S11010-008-9830-5  0.573
2008 Duncan JS, Gyenis L, Lenehan J, Bretner M, Graves LM, Haystead TA, Litchfield DW. An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets. Molecular & Cellular Proteomics : McP. 7: 1077-88. PMID 18258654 DOI: 10.1074/Mcp.M700559-Mcp200  0.479
2008 Duncan JS, Litchfield DW. Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2. Biochimica Et Biophysica Acta. 1784: 33-47. PMID 17931986 DOI: 10.1016/J.Bbapap.2007.08.017  0.516
2007 French AC, Luscher B, Litchfield DW. Development of a stabilized form of the regulatory CK2beta subunit that inhibits cell proliferation. The Journal of Biological Chemistry. 282: 29667-77. PMID 17681943 DOI: 10.1074/Jbc.M706457200  0.495
2007 Behrsin CD, Bailey ML, Bateman KS, Hamilton KS, Wahl LM, Brandl CJ, Shilton BH, Litchfield DW. Functionally important residues in the peptidyl-prolyl isomerase Pin1 revealed by unigenic evolution. Journal of Molecular Biology. 365: 1143-62. PMID 17113106 DOI: 10.1016/J.Jmb.2006.10.078  0.424
2006 Canton DA, Olsten ME, Niederstrasser H, Cooper JA, Litchfield DW. The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein. The Journal of Biological Chemistry. 281: 36347-59. PMID 16987810 DOI: 10.1074/Jbc.M607595200  0.478
2006 Panasyuk G, Nemazanyy I, Zhyvoloup A, Bretner M, Litchfield DW, Filonenko V, Gout IT. Nuclear export of S6K1 II is regulated by protein kinase CK2 phosphorylation at Ser-17. The Journal of Biological Chemistry. 281: 31188-201. PMID 16895915 DOI: 10.1074/Jbc.M602618200  0.566
2006 Behrsin CD, Brandl CJ, Litchfield DW, Shilton BH, Wahl LM. Development of an unbiased statistical method for the analysis of unigenic evolution. Bmc Bioinformatics. 7: 150. PMID 16545116 DOI: 10.1186/1471-2105-7-150  0.339
2006 Canton DA, Litchfield DW. The shape of things to come: an emerging role for protein kinase CK2 in the regulation of cell morphology and the cytoskeleton. Cellular Signalling. 18: 267-75. PMID 16126370 DOI: 10.1016/J.Cellsig.2005.07.008  0.588
2006 Olsten ME, Litchfield D. Casein kinase II alpha 1 Afcs-Nature Molecule Pages. DOI: 10.1038/Mp.A000109.01  0.402
2005 Olsten ME, Weber JE, Litchfield DW. CK2 interacting proteins: emerging paradigms for CK2 regulation? Molecular and Cellular Biochemistry. 274: 115-24. PMID 16335533 DOI: 10.1007/S11010-005-3072-6  0.573
2005 Zien P, Duncan JS, Skierski J, Bretner M, Litchfield DW, Shugar D. Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2. Biochimica Et Biophysica Acta. 1754: 271-80. PMID 16203192 DOI: 10.1016/J.Bbapap.2005.07.039  0.533
2005 Bibby AC, Litchfield DW. The multiple personalities of the regulatory subunit of protein kinase CK2: CK2 dependent and CK2 independent roles reveal a secret identity for CK2beta. International Journal of Biological Sciences. 1: 67-79. PMID 15951851  0.519
2005 Canton DA, Olsten ME, Kim K, Doherty-Kirby A, Lajoie G, Cooper JA, Litchfield DW. The pleckstrin homology domain-containing protein CKIP-1 is involved in regulation of cell morphology and the actin cytoskeleton and interaction with actin capping protein. Molecular and Cellular Biology. 25: 3519-34. PMID 15831458 DOI: 10.1128/Mcb.25.9.3519-3534.2005  0.456
2005 Stolk M, Cooper E, Vilk G, Litchfield DW, Hammond JR. Subtype-specific regulation of equilibrative nucleoside transporters by protein kinase CK2. The Biochemical Journal. 386: 281-9. PMID 15500446 DOI: 10.1042/Bj20041571  0.773
2004 Olsten ME, Litchfield DW. Order or chaos? An evaluation of the regulation of protein kinase CK2. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 82: 681-93. PMID 15674436 DOI: 10.1139/O04-116  0.564
2004 Olsten ME, Canton DA, Zhang C, Walton PA, Litchfield DW. The Pleckstrin homology domain of CK2 interacting protein-1 is required for interactions and recruitment of protein kinase CK2 to the plasma membrane. The Journal of Biological Chemistry. 279: 42114-27. PMID 15254037 DOI: 10.1074/Jbc.M407628200  0.413
2003 Donella-Deana A, Cesaro L, Sarno S, Ruzzene M, Brunati AM, Marin O, Vilk G, Doherty-Kirby A, Lajoie G, Litchfield DW, Pinna LA. Tyrosine phosphorylation of protein kinase CK2 by Src-related tyrosine kinases correlates with increased catalytic activity. The Biochemical Journal. 372: 841-9. PMID 12628006 DOI: 10.1042/Bj20021905  0.822
2003 Litchfield DW. Protein kinase CK2: structure, regulation and role in cellular decisions of life and death. The Biochemical Journal. 369: 1-15. PMID 12396231 DOI: 10.1042/Bj20021469  0.592
2002 Sun JM, Chen HY, Moniwa M, Litchfield DW, Seto E, Davie JR. The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2. The Journal of Biological Chemistry. 277: 35783-6. PMID 12176973 DOI: 10.1074/Jbc.C200378200  0.301
2002 Zhang C, Vilk G, Canton DA, Litchfield DW. Phosphorylation regulates the stability of the regulatory CK2beta subunit. Oncogene. 21: 3754-64. PMID 12032843 DOI: 10.1038/Sj.Onc.1205467  0.828
2002 Messenger MM, Saulnier RB, Gilchrist AD, Diamond P, Gorbsky GJ, Litchfield DW. Interactions between protein kinase CK2 and Pin1. Evidence for phosphorylation-dependent interactions. The Journal of Biological Chemistry. 277: 23054-64. PMID 11940573 DOI: 10.1074/Jbc.M200111200  0.412
2002 Hanawa H, Ma Y, Mikolajczak SA, Charles ML, Yoshida T, Yoshida R, Strathdee CA, Litchfield DW, Ochi A. A novel costimulatory signaling in human T lymphocytes by a splice variant of CD28. Blood. 99: 2138-45. PMID 11877290 DOI: 10.1182/Blood.V99.6.2138  0.301
2001 Litchfield DW, Bosc DG, Canton DA, Saulnier RB, Vilk G, Zhang C. Functional specialization of CK2 isoforms and characterization of isoform-specific binding partners. Molecular and Cellular Biochemistry. 227: 21-9. PMID 11827170 DOI: 10.1007/978-1-4615-1723-8_3  0.802
2001 Vilk G, Derksen DR, Litchfield DW. Inducible expression of the regulatory protein kinase CK2beta subunit: incorporation into complexes with catalytic CK2 subunits and re-examination of the effects of CK2beta on cell proliferation. Journal of Cellular Biochemistry. 84: 84-99. PMID 11746518 DOI: 10.1002/Jcb.1268  0.799
2001 Canton DA, Zhang C, Litchfield DW. Assembly of protein kinase CK2: investigation of complex formation between catalytic and regulatory subunits using a zinc-finger-deficient mutant of CK2beta. The Biochemical Journal. 358: 87-94. PMID 11485555 DOI: 10.1042/0264-6021:3580087  0.47
2001 Tan CM, Kelvin DJ, Litchfield DW, Ferguson SS, Feldman RD. Tyrosine kinase-mediated serine phosphorylation of adenylyl cyclase. Biochemistry. 40: 1702-9. PMID 11327830 DOI: 10.1021/Bi0015818  0.573
2001 CANTON DA, ZHANG C, LITCHFIELD DW. Assembly of protein kinase CK2: investigation of complex formation between catalytic and regulatory subunits using a zinc-finger-deficient mutant of CK2β Biochemical Journal. 358: 87-94. DOI: 10.1042/bj3580087  0.387
2000 Bosc DG, Graham KC, Saulnier RB, Zhang C, Prober D, Gietz RD, Litchfield DW. Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2. The Journal of Biological Chemistry. 275: 14295-306. PMID 10799509 DOI: 10.1074/Jbc.275.19.14295  0.507
2000 Graham KC, Litchfield DW. The regulatory beta subunit of protein kinase CK2 mediates formation of tetrameric CK2 complexes. The Journal of Biological Chemistry. 275: 5003-10. PMID 10671540 DOI: 10.1074/Jbc.275.7.5003  0.426
1999 Vilk G, Saulnier RB, St Pierre R, Litchfield DW. Inducible expression of protein kinase CK2 in mammalian cells. Evidence for functional specialization of CK2 isoforms. The Journal of Biological Chemistry. 274: 14406-14. PMID 10318865 DOI: 10.1074/Jbc.274.20.14406  0.818
1999 Chan AK, Persad S, Litchfield DW, Wright JA. Ribonucleotide reductase R2 protein is phosphorylated at serine-20 by P34cdc2 kinase. Biochimica Et Biophysica Acta. 1448: 363-71. PMID 9990288 DOI: 10.1016/S0167-4889(98)00115-3  0.452
1999 Bosc DG, Lüscher B, Litchfield DW. Expression and regulation of protein kinase CK2 during the cell cycle Molecular and Cellular Biochemistry. 191: 213-222. DOI: 10.1007/978-1-4419-8624-5_26  0.548
1998 Saleh A, Schieltz D, Ting N, McMahon SB, Litchfield DW, Yates JR, Lees-Miller SP, Cole MD, Brandl CJ. Tra1p is a component of the yeast Ada.Spt transcriptional regulatory complexes. The Journal of Biological Chemistry. 273: 26559-65. PMID 9756893 DOI: 10.1074/Jbc.273.41.26559  0.475
1998 Raman C, Kuo A, Deshane J, Litchfield DW, Kimberly RP. Regulation of casein kinase 2 by direct interaction with cell surface receptor CD5. The Journal of Biological Chemistry. 273: 19183-9. PMID 9668105 DOI: 10.1074/Jbc.273.30.19183  0.305
1998 Yee AA, Yin P, Siderovski DP, Mak TW, Litchfield DW, Arrowsmith CH. Cooperative interaction between the DNA-binding domains of PU.1 and IRF4 Journal of Molecular Biology. 279: 1075-1083. PMID 9642085 DOI: 10.1006/Jmbi.1998.1838  0.306
1998 Coqueret O, Martin N, Bérubé G, Rabbat M, Litchfield DW, Nepveu A. DNA binding by cut homeodomain proteins is down-modulated by casein kinase II. The Journal of Biological Chemistry. 273: 2561-6. PMID 9446557 DOI: 10.1074/jbc.273.5.2561  0.383
1997 Penner CG, Wang Z, Litchfield DW. Expression and localization of epitope-tagged protein kinase CK2. Journal of Cellular Biochemistry. 64: 525-37. PMID 9093902 DOI: 10.1002/(Sici)1097-4644(19970315)64:4<525::Aid-Jcb1>3.0.Co;2-T  0.449
1996 Doble BW, Chen Y, Bosc DG, Litchfield DW, Kardami E. Fibroblast growth factor-2 decreases metabolic coupling and stimulates phosphorylation as well as masking of connexin43 epitopes in cardiac myocytes. Circulation Research. 79: 647-58. PMID 8831488 DOI: 10.1161/01.Res.79.4.647  0.419
1996 Zhou X, Lu X, Richard C, Xiong W, Litchfield DW, Bittman R, Arthur G. 1-O-octadecyl-2-O-methyl-glycerophosphocholine inhibits the transduction of growth signals via the MAPK cascade in cultured MCF-7 cells. The Journal of Clinical Investigation. 98: 937-44. PMID 8770865 DOI: 10.1172/Jci118877  0.315
1995 Gietz RD, Graham KC, Litchfield DW. Interactions between the subunits of casein kinase II. The Journal of Biological Chemistry. 270: 13017-21. PMID 7768894 DOI: 10.1074/Jbc.270.22.13017  0.323
1995 Bosc DG, Slominski E, Sichler C, Litchfield DW. Phosphorylation of casein kinase II by p34cdc2. Identification of phosphorylation sites using phosphorylation site mutants in vitro. The Journal of Biological Chemistry. 270: 25872-8. PMID 7592773 DOI: 10.1074/Jbc.270.43.25872  0.561
1995 Litchfield DW, Bosc DG, Slominski E. The protein kinase from mitotic human cells that phosphorylates Ser-209 on the casein kinase II beta-subunit is p34cdc2. Biochimica Et Biophysica Acta. 1269: 69-78. PMID 7578274 DOI: 10.1016/0167-4889(95)00100-7  0.613
1995 Chen G, Shi L, Litchfield DW, Greenberg AH. Rescue from granzyme B-induced apoptosis by Wee1 kinase. The Journal of Experimental Medicine. 181: 2295-300. PMID 7539047 DOI: 10.1084/Jem.181.6.2295  0.552
1994 Lüscher B, Litchfield DW. Biosynthesis of casein kinase II in lymphoid cell lines. European Journal of Biochemistry. 220: 521-6. PMID 8125110 DOI: 10.1111/J.1432-1033.1994.Tb18651.X  0.411
1994 Shi L, Nishioka WK, Th'ng J, Bradbury EM, Litchfield DW, Greenberg AH. Premature p34cdc2 activation required for apoptosis. Science (New York, N.Y.). 263: 1143-5. PMID 8108732 DOI: 10.1126/Science.8108732  0.475
1994 Litchfield DW, Lüscher B. Casein kinase II in signal transduction and cell cycle regulation. Molecular and Cellular Biochemistry. 187-99. PMID 7935350 DOI: 10.1007/Bf01076770  0.582
1994 Lee W, Harvey TS, Yin Y, Yau P, Litchfield D, Arrowsmith CH. Solution structure of the tetrameric minimum transforming domain of p53 Nature Structural Biology. 1: 877-890. PMID 7773777 DOI: 10.1038/Nsb1294-877  0.383
1994 Hoyt C, Oh C, Beekman J, Litchfield D, Lerea K. Identifying and characterizing casein kinase II in human platelets Blood. 83: 3517-3523. DOI: 10.1182/blood.V83.12.3517.3517  0.446
1993 Chan AK, Litchfield DW, Wright JA. Phosphorylation of ribonucleotide reductase R2 protein: in vivo and in vitro evidence of a role for p34cdc2 and CDK2 protein kinases. Biochemistry. 32: 12835-40. PMID 8251505 DOI: 10.1021/Bi00210A036  0.514
1992 Litchfield D, Lüscher B, Lozeman F, Eisenman R, Krebs E. Phosphorylation of casein kinase II by p34cdc2 in vitro and at mitosis. Journal of Biological Chemistry. 267: 13943-13951. DOI: 10.1016/s0021-9258(19)49661-0  0.433
1991 Apel E, Litchfield D, Clark R, Krebs E, Storm D. Phosphorylation of neuromodulin (GAP-43) by casein kinase II. Identification of phosphorylation sites and regulation by calmodulin Journal of Biological Chemistry. 266: 10544-10551. DOI: 10.1016/s0021-9258(18)99258-6  0.468
1991 Litchfield D, Lozeman F, Cicirelli M, Harrylock M, Ericsson L, Piening C, Krebs E. Phosphorylation of the beta subunit of casein kinase II in human A431 cells. Identification of the autophosphorylation site and a site phosphorylated by p34cdc2. Journal of Biological Chemistry. 266: 20380-20389. DOI: 10.1016/s0021-9258(18)54934-6  0.414
1990 Litchfield DW, Arendt A, Lozeman FJ, Krebs EG, Hargrave PA, Palczewski K. Synthetic phosphopeptides are substrates for casein kinase II. Febs Letters. 261: 117-20. PMID 2307228 DOI: 10.1016/0014-5793(90)80650-8  0.552
1990 Lozeman FJ, Litchfield DW, Piening C, Takio K, Walsh KA, Krebs EG. Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II. Biochemistry. 29: 8436-47. PMID 2174700 DOI: 10.1021/Bi00488A034  0.387
1990 Lüscher B, Christenson E, Litchfield DW, Krebs EG, Eisenman RN. Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation. Nature. 344: 517-22. PMID 2157164 DOI: 10.1038/344517A0  0.452
1990 Haystead TA, Weiel JE, Litchfield DW, Tsukitani Y, Fischer EH, Krebs EG. Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal. Journal of Biological Chemistry. 265: 16571-16580. DOI: 10.1016/s0021-9258(17)46261-2  0.314
1988 Krebs EG, Eisenman RN, Kuenzel EA, Litchfield DW, Lozeman FJ, Lüscher B, Sommercorn J. Casein kinase II as a potentially important enzyme concerned with signal transduction. Cold Spring Harbor Symposia On Quantitative Biology. 53: 77-84. PMID 3076090 DOI: 10.1101/Sqb.1988.053.01.012  0.432
1987 Cates GA, Litchfield DW, Narindrasorasak S, Nandan D, Ball EH, Sanwal BD. Phosphorylation of a gelatin-binding protein from L6 myoblasts by protein kinase C. Febs Letters. 218: 195-9. PMID 3595866 DOI: 10.1016/0014-5793(87)81045-1  0.556
1987 Litchfield DW, Ball EH. Phosphorylation of caldesmon77 by protein kinase C in vitro and in intact human platelets. Journal of Biological Chemistry. 262: 8056-8060. DOI: 10.1016/s0021-9258(18)47526-6  0.425
1986 Litchfield DW, Ball EH. Phosphorylation of the cytoskeletal protein talin by protein kinase C. Biochemical and Biophysical Research Communications. 134: 1276-83. PMID 3080999 DOI: 10.1016/0006-291X(86)90388-8  0.583
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