David W. Litchfield - Publications

The University of Western Ontario (Canada) 
Cell Biology, Biochemistry, Molecular Biology

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Bowie LE, Maiuri T, Alpaugh M, Gabriel M, Arbez N, Galleguillos D, Hung CLK, Patel S, Xia J, Hertz NT, Ross CA, Litchfield DW, Sipione S, Truant R. N6-Furfuryladenine is protective in Huntington's disease models by signaling huntingtin phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. PMID 29987005 DOI: 10.1073/pnas.1801772115  0.44
2017 Tse WH, Gyenis L, Litchfield DW, Zhang J. Cellular interaction influenced by surface modification strategies of gelatin-based nanoparticles. Journal of Biomaterials Applications. 31: 1087-1096. PMID 28178901 DOI: 10.1177/0885328216684651  0.44
2016 Rabalski AJ, Gyenis L, Litchfield DW. Molecular Pathways: Emergence of Protein Kinase CK2 (CSNK2) as a Potential Target to Inhibit Survival and DNA Damage Response and Repair Pathways in Cancer Cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 22: 2840-7. PMID 27306791 DOI: 10.1158/1078-0432.CCR-15-1314  0.44
2015 Gamper I, Fleck D, Barlin M, Spehr M, El Sayad S, Kleine H, Maxeiner S, Schalla C, Aydin G, Hoss M, Litchfield DW, Lüscher B, Zenke M, Sechi A. GAR22β regulates cell migration, sperm motility and axoneme structure. Molecular Biology of the Cell. PMID 26564797 DOI: 10.1091/mbc.E15-06-0426  0.32
2015 Dick SA, Chang NC, Dumont NA, Bell RA, Putinski C, Kawabe Y, Litchfield DW, Rudnicki MA, Megeney LA. Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 26372956 DOI: 10.1073/pnas.1512869112  0.32
2015 Litchfield DW, Shilton BH, Brandl CJ, Gyenis L. Pin1: Intimate involvement with the regulatory protein kinase networks in the global phosphorylation landscape. Biochimica Et Biophysica Acta. 1850: 2077-86. PMID 25766872 DOI: 10.1016/j.bbagen.2015.02.018  0.44
2015 Innes BT, Sowole MA, Gyenis L, Dubinsky M, Konermann L, Litchfield DW, Brandl CJ, Shilton BH. Peroxide-mediated oxidation and inhibition of the peptidyl-prolyl isomerase Pin1. Biochimica Et Biophysica Acta. 1852: 905-12. PMID 25595659 DOI: 10.1016/j.bbadis.2014.12.025  0.44
2015 St-Denis N, Gabriel M, Turowec JP, Gloor GB, Li SS, Gingras AC, Litchfield DW. Systematic investigation of hierarchical phosphorylation by protein kinase CK2. Journal of Proteomics. 118: 49-62. PMID 25449829 DOI: 10.1016/j.jprot.2014.10.020  0.32
2014 Deplus R, Blanchon L, Rajavelu A, Boukaba A, Defrance M, Luciani J, Rothé F, Dedeurwaerder S, Denis H, Brinkman AB, Simmer F, Müller F, Bertin B, Berdasco M, Putmans P, ... ... Litchfield DW, et al. Regulation of DNA methylation patterns by CK2-mediated phosphorylation of Dnmt3a. Cell Reports. 8: 743-53. PMID 25066127 DOI: 10.1016/j.celrep.2014.06.048  0.32
2014 Turowec JP, Zukowski SA, Knight JD, Smalley DM, Graves LM, Johnson GL, Li SS, Lajoie GA, Litchfield DW. An unbiased proteomic screen reveals caspase cleavage is positively and negatively regulated by substrate phosphorylation. Molecular & Cellular Proteomics : McP. 13: 1184-97. PMID 24556848 DOI: 10.1074/mcp.M113.037374  0.32
2014 Penuela S, Lohman AW, Lai W, Gyenis L, Litchfield DW, Isakson BE, Laird DW. Diverse post-translational modifications of the pannexin family of channel-forming proteins. Channels (Austin, Tex.). 8: 124-30. PMID 24418849 DOI: 10.4161/chan.27422  0.44
2013 Estey MP, Di Ciano-Oliveira C, Froese CD, Fung KY, Steels JD, Litchfield DW, Trimble WS. Mitotic regulation of SEPT9 protein by cyclin-dependent kinase 1 (Cdk1) and Pin1 protein is important for the completion of cytokinesis. The Journal of Biological Chemistry. 288: 30075-86. PMID 23990466 DOI: 10.1074/jbc.M113.474932  0.32
2013 Turowec JP, Vilk G, Gabriel M, Litchfield DW. Characterizing the convergence of protein kinase CK2 and caspase-3 reveals isoform-specific phosphorylation of caspase-3 by CK2α': implications for pathological roles of CK2 in promoting cancer cell survival. Oncotarget. 4: 560-71. PMID 23599180  0.52
2013 Gyenis L, Turowec JP, Bretner M, Litchfield DW. Chemical proteomics and functional proteomics strategies for protein kinase inhibitor validation and protein kinase substrate identification: applications to protein kinase CK2. Biochimica Et Biophysica Acta. 1834: 1352-8. PMID 23416530 DOI: 10.1016/j.bbapap.2013.02.006  0.44
2013 Innes BT, Bailey ML, Brandl CJ, Shilton BH, Litchfield DW. Non-catalytic participation of the Pin1 peptidyl-prolyl isomerase domain in target binding. Frontiers in Physiology. 4: 18. PMID 23407864 DOI: 10.3389/fphys.2013.00018  0.32
2013 Gyenis L, Kuś A, Bretner M, Litchfield DW. Functional proteomics strategy for validation of protein kinase inhibitors reveals new targets for a TBB-derived inhibitor of protein kinase CK2. Journal of Proteomics. 81: 70-9. PMID 23017496 DOI: 10.1016/j.jprot.2012.09.017  0.44
2012 Martić S, Beheshti S, Kraatz HB, Litchfield DW. Electrochemical investigations of Tau protein phosphorylations and interactions with Pin1. Chemistry & Biodiversity. 9: 1693-702. PMID 22976962 DOI: 10.1002/cbdv.201100418  0.32
2012 Marti? S, Gabriel M, Turowec JP, Litchfield DW, Kraatz HB. Versatile strategy for biochemical, electrochemical and immunoarray detection of protein phosphorylations. Journal of the American Chemical Society. 134: 17036-45. PMID 22764889 DOI: 10.1021/ja302586q  0.32
2012 Penuela S, Gyenis L, Ablack A, Churko JM, Berger AC, Litchfield DW, Lewis JD, Laird DW. Loss of pannexin 1 attenuates melanoma progression by reversion to a melanocytic phenotype. The Journal of Biological Chemistry. 287: 29184-93. PMID 22753409 DOI: 10.1074/jbc.M112.377176  0.32
2012 Duncan JS, Haystead TA, Litchfield DW. Chemoproteomic characterization of protein kinase inhibitors using immobilized ATP. Methods in Molecular Biology (Clifton, N.J.). 795: 119-34. PMID 21960219 DOI: 10.1007/978-1-61779-337-0_8  0.32
2011 Gyenis L, Duncan JS, Turowec JP, Bretner M, Litchfield DW. Unbiased functional proteomics strategy for protein kinase inhibitor validation and identification of bona fide protein kinase substrates: application to identification of EEF1D as a substrate for CK2. Journal of Proteome Research. 10: 4887-901. PMID 21936567 DOI: 10.1021/pr2008994  0.32
2011 Turowec JP, Duncan JS, Gloor GB, Litchfield DW. Regulation of caspase pathways by protein kinase CK2: identification of proteins with overlapping CK2 and caspase consensus motifs. Molecular and Cellular Biochemistry. 356: 159-67. PMID 21750976 DOI: 10.1007/s11010-011-0972-5  0.32
2011 Graves LM, Litchfield DW. "Going KiNativ": probing the Native Kinome. Chemistry & Biology. 18: 683-4. PMID 21700204 DOI: 10.1016/j.chembiol.2011.06.001  0.32
2011 St-Denis NA, Bailey ML, Parker EL, Vilk G, Litchfield DW. Localization of phosphorylated CK2alpha to the mitotic spindle requires the peptidyl-prolyl isomerase Pin1. Journal of Cell Science. 124: 2341-8. PMID 21693590 DOI: 10.1242/jcs.077446  0.32
2011 Duncan JS, Turowec JP, Duncan KE, Vilk G, Wu C, Lüscher B, Li SS, Gloor GB, Litchfield DW. A peptide-based target screen implicates the protein kinase CK2 in the global regulation of caspase signaling. Science Signaling. 4: ra30. PMID 21558555 DOI: 10.1126/scisignal.2001682  0.32
2011 Duncan KE, Dempsey BR, Killip LE, Adams J, Bailey ML, Lajoie GA, Litchfield DW, Brandl CJ, Shaw GS, Shilton BH. Discovery and characterization of a nonphosphorylated cyclic peptide inhibitor of the peptidylprolyl isomerase, Pin1. Journal of Medicinal Chemistry. 54: 3854-65. PMID 21545152 DOI: 10.1021/jm200156c  0.32
2011 Zheng Y, Qin H, Frank SJ, Deng L, Litchfield DW, Tefferi A, Pardanani A, Lin FT, Li J, Sha B, Benveniste EN. A CK2-dependent mechanism for activation of the JAK-STAT signaling pathway. Blood. 118: 156-66. PMID 21527517 DOI: 10.1182/blood-2010-01-266320  0.32
2011 Lukashova V, Szabó EZ, Jinadasa T, Mokhov A, Litchfield DW, Orlowski J. CK2 phosphorylation of an acidic Ser/Thr di-isoleucine motif in the Na+/H+ exchanger NHE5 isoform promotes association with beta-arrestin2 and endocytosis. The Journal of Biological Chemistry. 286: 11456-68. PMID 21296876 DOI: 10.1074/jbc.M110.182881  0.32
2011 Raaf J, Bischoff N, Klopffleisch K, Brunstein E, Olsen BB, Vilk G, Litchfield DW, Issinger OG, Niefind K. Interaction between CK2α and CK2β, the subunits of protein kinase CK2: thermodynamic contributions of key residues on the CK2α surface. Biochemistry. 50: 512-22. PMID 21142136 DOI: 10.1021/bi1013563  0.52
2010 Turowec JP, Duncan JS, French AC, Gyenis L, St Denis NA, Vilk G, Litchfield DW. Protein kinase CK2 is a constitutively active enzyme that promotes cell survival: strategies to identify CK2 substrates and manipulate its activity in mammalian cells. Methods in Enzymology. 484: 471-93. PMID 21036246 DOI: 10.1016/B978-0-12-381298-8.00023-X  0.52
2010 Mani RS, Yu Y, Fang S, Lu M, Fanta M, Zolner AE, Tahbaz N, Ramsden DA, Litchfield DW, Lees-Miller SP, Weinfeld M. Dual modes of interaction between XRCC4 and polynucleotide kinase/phosphatase: implications for nonhomologous end joining. The Journal of Biological Chemistry. 285: 37619-29. PMID 20852255 DOI: 10.1074/jbc.M109.058719  0.32
2010 Stendel C, Roos A, Kleine H, Arnaud E, Ozçelik M, Sidiropoulos PN, Zenker J, Schüpfer F, Lehmann U, Sobota RM, Litchfield DW, Lüscher B, Chrast R, Suter U, Senderek J. SH3TC2, a protein mutant in Charcot-Marie-Tooth neuropathy, links peripheral nerve myelination to endosomal recycling. Brain : a Journal of Neurology. 133: 2462-74. PMID 20826437 DOI: 10.1093/brain/awq168  0.32
2010 Bragdon B, Thinakaran S, Moseychuk O, King D, Young K, Litchfield DW, Petersen NO, Nohe A. Casein kinase 2 beta-subunit is a regulator of bone morphogenetic protein 2 signaling. Biophysical Journal. 99: 897-904. PMID 20682268 DOI: 10.1016/j.bpj.2010.04.070  0.32
2010 Peters W, Willnow S, Duisken M, Kleine H, Macherey T, Duncan KE, Litchfield DW, Lüscher B, Weinhold E. Enzymatic site-specific functionalization of protein methyltransferase substrates with alkynes for click labeling. Angewandte Chemie (International Ed. in English). 49: 5170-3. PMID 20572224 DOI: 10.1002/anie.201001240  0.32
2010 Hellwig CT, Ludwig-Galezowska AH, Concannon CG, Litchfield DW, Prehn JH, Rehm M. Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation. Journal of Cell Science. 123: 1401-6. PMID 20356928 DOI: 10.1242/jcs.061143  0.32
2010 Duncan JS, Turowec JP, Vilk G, Li SS, Gloor GB, Litchfield DW. Regulation of cell proliferation and survival: convergence of protein kinases and caspases. Biochimica Et Biophysica Acta. 1804: 505-10. PMID 19900592 DOI: 10.1016/j.bbapap.2009.11.001  0.32
2009 St-Denis NA, Derksen DR, Litchfield DW. Evidence for regulation of mitotic progression through temporal phosphorylation and dephosphorylation of CK2alpha. Molecular and Cellular Biology. 29: 2068-81. PMID 19188443 DOI: 10.1128/MCB.01563-08  0.32
2009 Lahiry P, Wang J, Robinson JF, Turowec JP, Litchfield DW, Lanktree MB, Gloor GB, Puffenberger EG, Strauss KA, Martens MB, Ramsay DA, Rupar CA, Siu V, Hegele RA. A multiplex human syndrome implicates a key role for intestinal cell kinase in development of central nervous, skeletal, and endocrine systems. American Journal of Human Genetics. 84: 134-47. PMID 19185282 DOI: 10.1016/j.ajhg.2008.12.017  0.32
2008 Kerman K, Song H, Duncan JS, Litchfield DW, Kraatz HB. Peptide biosensors for the electrochemical measurement of protein kinase activity. Analytical Chemistry. 80: 9395-401. PMID 18989981 DOI: 10.1021/ac801208e  0.32
2008 Kleine H, Poreba E, Lesniewicz K, Hassa PO, Hottiger MO, Litchfield DW, Shilton BH, Lüscher B. Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation. Molecular Cell. 32: 57-69. PMID 18851833 DOI: 10.1016/j.molcel.2008.08.009  0.32
2008 Bailey ML, Shilton BH, Brandl CJ, Litchfield DW. The dual histidine motif in the active site of Pin1 has a structural rather than catalytic role. Biochemistry. 47: 11481-9. PMID 18844375 DOI: 10.1021/bi800964q  0.32
2008 Maingret F, Coste B, Hao J, Giamarchi A, Allen D, Crest M, Litchfield DW, Adelman JP, Delmas P. Neurotransmitter modulation of small-conductance Ca2+-activated K+ channels by regulation of Ca2+ gating. Neuron. 59: 439-49. PMID 18701069 DOI: 10.1016/j.neuron.2008.05.026  0.32
2008 Vilk G, Weber JE, Turowec JP, Duncan JS, Wu C, Derksen DR, Zien P, Sarno S, Donella-Deana A, Lajoie G, Pinna LA, Li SS, Litchfield DW. Protein kinase CK2 catalyzes tyrosine phosphorylation in mammalian cells. Cellular Signalling. 20: 1942-51. PMID 18662771 DOI: 10.1016/j.cellsig.2008.07.002  0.32
2008 Gyenis L, Litchfield DW. The emerging CK2 interactome: insights into the regulation and functions of CK2. Molecular and Cellular Biochemistry. 316: 5-14. PMID 18553055 DOI: 10.1007/s11010-008-9830-5  0.44
2008 Duncan JS, Gyenis L, Lenehan J, Bretner M, Graves LM, Haystead TA, Litchfield DW. An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets. Molecular & Cellular Proteomics : McP. 7: 1077-88. PMID 18258654 DOI: 10.1074/mcp.M700559-MCP200  0.32
2008 Duncan JS, Litchfield DW. Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2. Biochimica Et Biophysica Acta. 1784: 33-47. PMID 17931986 DOI: 10.1016/j.bbapap.2007.08.017  0.44
2007 French AC, Luscher B, Litchfield DW. Development of a stabilized form of the regulatory CK2beta subunit that inhibits cell proliferation. The Journal of Biological Chemistry. 282: 29667-77. PMID 17681943 DOI: 10.1074/jbc.M706457200  0.44
2006 Canton DA, Olsten ME, Niederstrasser H, Cooper JA, Litchfield DW. The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein. The Journal of Biological Chemistry. 281: 36347-59. PMID 16987810 DOI: 10.1074/jbc.M607595200  0.32
2006 Canton DA, Litchfield DW. The shape of things to come: an emerging role for protein kinase CK2 in the regulation of cell morphology and the cytoskeleton. Cellular Signalling. 18: 267-75. PMID 16126370 DOI: 10.1016/j.cellsig.2005.07.008  0.52
2005 Zien P, Duncan JS, Skierski J, Bretner M, Litchfield DW, Shugar D. Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2. Biochimica Et Biophysica Acta. 1754: 271-80. PMID 16203192 DOI: 10.1016/j.bbapap.2005.07.039  0.44
2005 Canton DA, Olsten ME, Kim K, Doherty-Kirby A, Lajoie G, Cooper JA, Litchfield DW. The pleckstrin homology domain-containing protein CKIP-1 is involved in regulation of cell morphology and the actin cytoskeleton and interaction with actin capping protein. Molecular and Cellular Biology. 25: 3519-34. PMID 15831458 DOI: 10.1128/MCB.25.9.3519-3534.2005  0.32
2005 Stolk M, Cooper E, Vilk G, Litchfield DW, Hammond JR. Subtype-specific regulation of equilibrative nucleoside transporters by protein kinase CK2. The Biochemical Journal. 386: 281-9. PMID 15500446 DOI: 10.1042/BJ20041571  0.32
2004 Olsten ME, Canton DA, Zhang C, Walton PA, Litchfield DW. The Pleckstrin homology domain of CK2 interacting protein-1 is required for interactions and recruitment of protein kinase CK2 to the plasma membrane. The Journal of Biological Chemistry. 279: 42114-27. PMID 15254037 DOI: 10.1074/jbc.M407628200  0.32
2003 Donella-Deana A, Cesaro L, Sarno S, Ruzzene M, Brunati AM, Marin O, Vilk G, Doherty-Kirby A, Lajoie G, Litchfield DW, Pinna LA. Tyrosine phosphorylation of protein kinase CK2 by Src-related tyrosine kinases correlates with increased catalytic activity. The Biochemical Journal. 372: 841-9. PMID 12628006 DOI: 10.1042/BJ20021905  0.32
2002 Sun JM, Chen HY, Moniwa M, Litchfield DW, Seto E, Davie JR. The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2. The Journal of Biological Chemistry. 277: 35783-6. PMID 12176973 DOI: 10.1074/jbc.C200378200  0.32
2002 Zhang C, Vilk G, Canton DA, Litchfield DW. Phosphorylation regulates the stability of the regulatory CK2beta subunit. Oncogene. 21: 3754-64. PMID 12032843 DOI: 10.1038/sj.onc.1205467  0.52
2002 Messenger MM, Saulnier RB, Gilchrist AD, Diamond P, Gorbsky GJ, Litchfield DW. Interactions between protein kinase CK2 and Pin1. Evidence for phosphorylation-dependent interactions. The Journal of Biological Chemistry. 277: 23054-64. PMID 11940573 DOI: 10.1074/jbc.M200111200  0.32
2001 Litchfield DW, Bosc DG, Canton DA, Saulnier RB, Vilk G, Zhang C. Functional specialization of CK2 isoforms and characterization of isoform-specific binding partners. Molecular and Cellular Biochemistry. 227: 21-9. PMID 11827170  0.52
2001 Vilk G, Derksen DR, Litchfield DW. Inducible expression of the regulatory protein kinase CK2beta subunit: incorporation into complexes with catalytic CK2 subunits and re-examination of the effects of CK2beta on cell proliferation. Journal of Cellular Biochemistry. 84: 84-99. PMID 11746518 DOI: 10.1002/jcb.1268  0.52
1999 Vilk G, Saulnier RB, St Pierre R, Litchfield DW. Inducible expression of protein kinase CK2 in mammalian cells. Evidence for functional specialization of CK2 isoforms. The Journal of Biological Chemistry. 274: 14406-14. PMID 10318865  0.52
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