Robert H. E. Hudson - Publications

Affiliations: 
The University of Western Ontario (Canada) 
Area:
Organic Chemistry

65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Workentin MS, Hudson RH. Tribute to J. Peter Guthrie, FCIC, FRSC 1942–2017 Canadian Journal of Chemistry. 96: iii-iv. DOI: 10.1139/Cjc-2018-0144  0.563
2016 Suchy M, Ettles C, Wisner JA, Matarazzo A, Hudson RH. Unusual C7- versus Normal 5'-O-Dimethoxytritylation of 6-Arylpyrrolocytidine Analogs. The Journal of Organic Chemistry. PMID 27529362 DOI: 10.1021/Acs.Joc.6B01584  0.71
2015 Snir JA, Suchy M, Lawrence KS, Hudson RH, Pasternak SH, Bartha R. Prolonged In Vivo Retention of a Cathepsin D Targeted Optical Contrast Agent in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. 48: 73-87. PMID 26401930 DOI: 10.3233/Jad-150123  0.779
2015 Wang X, Hudson RH. PNA Molecular Beacons Assembled by Post-Synthetic "Click" Chemistry Functionalization. Chembiochem : a European Journal of Chemical Biology. PMID 26227668 DOI: 10.1002/Cbic.201500248  0.607
2015 Suchý M, Milne M, Elmehriki AA, McVicar N, Li AX, Bartha R, Hudson RH. Introduction of Peripheral Carboxylates to Decrease the Charge on Tm(3+) DOTAM-Alkyl Complexes: Implications for Detection Sensitivity and in Vivo Toxicity of PARACEST MRI Contrast Agents. Journal of Medicinal Chemistry. 58: 6516-32. PMID 26214576 DOI: 10.1021/Acs.Jmedchem.5B00621  0.789
2015 Gobbo P, Luo W, Cho SJ, Wang X, Biesinger MC, Hudson RH, Workentin MS. Small gold nanoparticles for interfacial Staudinger-Bertozzi ligation. Organic & Biomolecular Chemistry. 13: 4605-12. PMID 25786777 DOI: 10.1039/C5Ob00372E  0.696
2014 Elmehriki AA, Suchý M, Chicas KJ, Wojciechowski F, Hudson RH. Synthesis and spectral characterization of environmentally responsive fluorescent deoxycytidine analogs. Artificial Dna, Pna & Xna. 5: e29174. PMID 25483932 DOI: 10.4161/adna.29174  0.764
2014 Hudson RH, Moustafa ME, Boyle PD. (E)-tert-Butyl 2-(5-{[4-(dimethylamino)phenyl]diazenyl}-2,6-dioxo-1H-pyrimid-in-3-yl)acetate dichloromethane monosolvate. Acta Crystallographica. Section E, Structure Reports Online. 70: o556-7. PMID 24860364 DOI: 10.1107/S1600536814007521  0.62
2014 Suchý M, Hudson RH. Pyrimidine-fused heterocyclic frameworks based on an N4-arylcytosine scaffold: synthesis, characterization, and PNA oligomerization of the fluorescent cytosine analogue 5,6-benzopC. The Journal of Organic Chemistry. 79: 3336-47. PMID 24666330 DOI: 10.1021/Jo402873E  0.54
2013 Stevens TK, Milne M, Elmehriki AA, Suchý M, Bartha R, Hudson RH. A DOTAM-based paraCEST agent favoring TSAP geometry for enhanced amide proton chemical shift dispersion and temperature sensitivity. Contrast Media & Molecular Imaging. 8: 289-92. PMID 23606433 DOI: 10.1002/Cmmi.1527  0.781
2013 St Amant AH, Engbers C, Hudson RH. A solid-phase CuAAC strategy for the synthesis of PNA containing nucleobase surrogates. Artificial Dna, Pna & Xna. 4: 4-10. PMID 23422048 DOI: 10.4161/adna.23982  0.37
2013 Ta R, Suchy M, Tam JH, Li AX, Martinez-Santiesteban FS, Scholl TJ, Hudson RH, Bartha R, Pasternak SH. A dual magnetic resonance imaging/fluorescent contrast agent for Cathepsin-D detection. Contrast Media & Molecular Imaging. 8: 127-39. PMID 23281285 DOI: 10.1002/Cmmi.1502  0.791
2013 McVicar N, Li AX, Suchý M, Hudson RH, Menon RS, Bartha R. Simultaneous in vivo pH and temperature mapping using a PARACEST-MRI contrast agent. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 70: 1016-25. PMID 23165779 DOI: 10.1002/Mrm.24539  0.556
2012 Suchý M, Li AX, Milne M, Bartha R, Hudson RH. DOTAM-type ligands possessing arginine pendant groups for use in PARACEST MRI. Contrast Media & Molecular Imaging. 7: 441-9. PMID 22821878 DOI: 10.1002/Cmmi.1461  0.787
2012 St Amant AH, Bean LA, Guthrie JP, Hudson RH. Click fleximers: a modular approach to purine base-expanded ribonucleoside analogues. Organic & Biomolecular Chemistry. 10: 6521-5. PMID 22752020 DOI: 10.1039/C2Ob25678A  0.665
2012 St Amant AH, Hudson RH. Synthesis and oligomerization of Fmoc/Boc-protected PNA monomers of 2,6-diaminopurine, 2-aminopurine and thymine. Organic & Biomolecular Chemistry. 10: 876-81. PMID 22159214 DOI: 10.1039/C1Ob06582C  0.476
2012 Torres AG, Fabani MM, Vigorito E, Williams D, Al-Obaidi N, Wojciechowski F, Hudson RH, Seitz O, Gait MJ. Chemical structure requirements and cellular targeting of microRNA-122 by peptide nucleic acids anti-miRs. Nucleic Acids Research. 40: 2152-67. PMID 22070883 DOI: 10.1093/Nar/Gkr885  0.708
2012 Milne M, Chicas K, Li A, Bartha R, Hudson RH. ParaCEST MRI contrast agents capable of derivatization via"click" chemistry. Organic & Biomolecular Chemistry. 10: 287-92. PMID 22069041 DOI: 10.1039/C1Ob06162C  0.758
2011 Moustafa ME, Hudson RH. An azo-based PNA monomer: synthesis and spectroscopic study. Nucleosides, Nucleotides & Nucleic Acids. 30: 740-51. PMID 21902475 DOI: 10.1080/15257770.2011.604661  0.708
2011 Swanick KN, Dodd DW, Price JT, Brazeau AL, Jones ND, Hudson RH, Ding Z. Electrogenerated chemiluminescence of triazole-modified deoxycytidine analogues in N,N-dimethylformamide. Physical Chemistry Chemical Physics : Pccp. 13: 17405-12. PMID 21887431 DOI: 10.1039/C1Cp22116G  0.782
2011 Milne M, Hudson RH. Contrast agents possessing high temperature sensitivity. Chemical Communications (Cambridge, England). 47: 9194-6. PMID 21748170 DOI: 10.1039/C1Cc13073K  0.741
2011 Suchý M, Elmehriki AA, Hudson RH. A remarkably simple protocol for the N-formylation of amino acid esters and primary amines. Organic Letters. 13: 3952-5. PMID 21707118 DOI: 10.1021/Ol201475J  0.428
2011 Wahba AS, Azizi F, Deleavey GF, Brown C, Robert F, Carrier M, Kalota A, Gewirtz AM, Pelletier J, Hudson RH, Damha MJ. Phenylpyrrolocytosine as an unobtrusive base modification for monitoring activity and cellular trafficking of siRNA. Acs Chemical Biology. 6: 912-9. PMID 21667942 DOI: 10.1021/Cb200070K  0.619
2011 Li AX, Suchy M, Li C, Gati JS, Meakin S, Hudson RH, Menon RS, Bartha R. In vivo detection of MRI-PARACEST agents in mouse brain tumors at 9.4 T. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 66: 67-72. PMID 21254213 DOI: 10.1002/Mrm.22772  0.778
2011 Guza R, Kotandeniya D, Murphy K, Dissanayake T, Lin C, Giambasu GM, Lad RR, Wojciechowski F, Amin S, Sturla SJ, Hudson RH, York DM, Jankowiak R, Jones R, Tretyakova NY. Influence of C-5 substituted cytosine and related nucleoside analogs on the formation of benzo[a]pyrene diol epoxide-dG adducts at CG base pairs of DNA. Nucleic Acids Research. 39: 3988-4006. PMID 21245046 DOI: 10.1093/Nar/Gkq1341  0.743
2010 Dodd DW, Jones ND, Hudson RH. Hydrogelation abilities of nucleobase-modified cytidines possessing substituted triazoles. Artificial Dna, Pna & Xna. 1: 90-95. PMID 21686244 DOI: 10.4161/adna.1.2.13975  0.769
2010 Suchý M, Li AX, Bartha R, Hudson RH. Synthesis of MRI contrast agents derived from DOTAM-Gly-L-Phe-OH incorporating a disulfide bridge: conjugation to a cell penetrating peptide and preparation of a dimeric agent. Bioorganic & Medicinal Chemistry Letters. 20: 5521-6. PMID 20705462 DOI: 10.1016/J.Bmcl.2010.07.070  0.629
2010 Suchý M, Ta R, Li AX, Wojciechowski F, Pasternak SH, Bartha R, Hudson RH. A paramagnetic chemical exchange-based MRI probe metabolized by cathepsin D: design, synthesis and cellular uptake studies. Organic & Biomolecular Chemistry. 8: 2560-6. PMID 20485791 DOI: 10.1039/B926639A  0.784
2010 Jones CK, Li AX, Suchý M, Hudson RH, Menon RS, Bartha R. In vivo detection of PARACEST agents with relaxation correction. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 63: 1184-92. PMID 20432289 DOI: 10.1002/Mrm.22340  0.54
2010 Dodd DW, Swanick KN, Price JT, Brazeau AL, Ferguson MJ, Jones ND, Hudson RH. Blue fluorescent deoxycytidine analogues: convergent synthesis, solid-state and electronic structure, and solvatochromism. Organic & Biomolecular Chemistry. 8: 663-6. PMID 20090985 DOI: 10.1039/B919921G  0.8
2010 Wahba AS, Esmaeili A, Damha MJ, Hudson RH. A single-label phenylpyrrolocytidine provides a molecular beacon-like response reporting HIV-1 RT RNase H activity. Nucleic Acids Research. 38: 1048-56. PMID 19933258 DOI: 10.1093/Nar/Gkp1022  0.602
2009 Wojciechowski F, Hudson RH. Peptide nucleic acid containing a meta-substituted phenylpyrrolocytosine exhibits a fluorescence response and increased binding affinity toward RNA. Organic Letters. 11: 4878-81. PMID 19788268 DOI: 10.1021/Ol9019474  0.754
2009 Hu J, Dodd DW, Hudson RH, Corey DR. Cellular localization and allele-selective inhibition of mutant huntingtin protein by peptide nucleic acid oligomers containing the fluorescent nucleobase [bis-o-(aminoethoxy)phenyl]pyrrolocytosine. Bioorganic & Medicinal Chemistry Letters. 19: 6181-4. PMID 19783436 DOI: 10.1016/J.Bmcl.2009.09.004  0.798
2009 Li AX, Suchy M, Jones CK, Hudson RH, Menon RS, Bartha R. Optimized MRI contrast for on-resonance proton exchange processes of PARACEST agents in biological systems. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 62: 1282-91. PMID 19780147 DOI: 10.1002/Mrm.22134  0.777
2009 Gantchev TG, Girouard S, Dodd DW, Wojciechowski F, Hudson RH, Hunting DJ. Gamma-radiation induced interstrand cross-links in PNA:DNA heteroduplexes. Biochemistry. 48: 7032-44. PMID 19469551 DOI: 10.1021/Bi9002474  0.771
2008 Suchý M, Li AX, Bartha R, Hudson RH. A new synthesis of cystamine modified Eu3+ DOTAM-Gly-Phe-OH: a conjugation ready temperature sensitive MRI contrast agent. Organic & Biomolecular Chemistry. 6: 3588-96. PMID 19082160 DOI: 10.1039/B808282K  0.629
2008 Li AX, Hudson RH, Barrett JW, Jones CK, Pasternak SH, Bartha R. Four-pool modeling of proton exchange processes in biological systems in the presence of MRI-paramagnetic chemical exchange saturation transfer (PARACEST) agents. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 60: 1197-206. PMID 18958857 DOI: 10.1002/Mrm.21752  0.603
2008 Wojciechowski F, Hudson RH. Exceptional fluorescence and hybridization properties of a phenylpyrrolocytosine in peptide nucleic acid. Nucleic Acids Symposium Series (2004). 401-2. PMID 18776423 DOI: 10.1093/nass/nrn204  0.75
2008 Wahba AS, Damha MJ, Hudson RH. RNA containing pyrrolocytidine base analogs: good binding affinity and fluorescence that responds to hybridization. Nucleic Acids Symposium Series (2004). 399-400. PMID 18776422 DOI: 10.1093/nass/nrn203  0.602
2008 Wahba AS, Damha MJ, Hudson RH. RNA containing pyrrolocytidine base analogs: increased binding affinity and fluorescence that responds to hybridization. Nucleic Acids Symposium Series (2004). 397-8. PMID 18776421 DOI: 10.1093/nass/nrn202  0.59
2008 Wojciechowski F, Hudson RH. Fluorescence and hybridization properties of peptide nucleic acid containing a substituted phenylpyrrolocytosine designed to engage Guanine with an additional H-bond. Journal of the American Chemical Society. 130: 12574-5. PMID 18761442 DOI: 10.1021/Ja804233G  0.769
2008 Suchý M, Li AX, Bartha R, Hudson RH. Analogs of Eu3+ DOTAM-Gly-Phe-OH and Tm3+ DOTAM-Gly-Lys-OH: synthesis and magnetic properties of potential PARACEST MRI contrast agents. Bioorganic & Medicinal Chemistry. 16: 6156-66. PMID 18457955 DOI: 10.1016/J.Bmc.2008.04.038  0.637
2008 Wojciechowski F, Hudson RH. A convenient route to N-[2-(Fmoc)aminoethyl]glycine esters and PNA oligomerization using a Bis-N-Boc nucleobase protecting group strategy. The Journal of Organic Chemistry. 73: 3807-16. PMID 18412392 DOI: 10.1021/Jo800195J  0.758
2008 Li AX, Wojciechowski F, Suchy M, Jones CK, Hudson RH, Menon RS, Bartha R. A sensitive PARACEST contrast agent for temperature MRI: Eu3+-DOTAM-glycine (Gly)-phenylalanine (Phe). Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 59: 374-81. PMID 18228602 DOI: 10.1002/Mrm.21482  0.773
2007 Hudson RH, Choghamarani AG. The 6-methoxymethyl derivative of pyrrolo-dC for selective fluorometric detection of guanosine-containing sequences. Nucleosides, Nucleotides & Nucleic Acids. 26: 533-7. PMID 18066851 DOI: 10.1080/15257770701489839  0.765
2007 Wojciechowski F, Hudson RH. Synthesis of a fluorescent PNA monomer containing 5-((9H-fluoren-2-yl)ethynyl)uracil. Nucleosides, Nucleotides & Nucleic Acids. 26: 1199-202. PMID 18058565 DOI: 10.1080/15257770701527802  0.779
2007 Wojciechowski F, Hudson RH. Introduction of chirality into PNA by replacement of the achiral methylene carbonyl linkage to the nucleobase. Nucleosides, Nucleotides & Nucleic Acids. 26: 1195-8. PMID 18058564 DOI: 10.1080/15257770701527794  0.771
2007 Dodd DW, Hudson RH. Analysis and purification of peptide nucleic acids by denaturing PAGE. Electrophoresis. 28: 3884-9. PMID 17922504 DOI: 10.1002/Elps.200700192  0.785
2007 Wojciechowski F, Suchy M, Li AX, Azab HA, Bartha R, Hudson RH. A robust and convergent synthesis of dipeptide-DOTAM conjugates as chelators for lanthanide ions: new PARACEST MRI agents. Bioconjugate Chemistry. 18: 1625-36. PMID 17711349 DOI: 10.1021/Bc0701287  0.789
2007 Hudson RH, Ghorbani-Choghamarani A. Oligodeoxynucleotides incorporating structurally simple 5-alkynyl-2'-deoxyuridines fluorometrically respond to hybridization. Organic & Biomolecular Chemistry. 5: 1845-8. PMID 17551631 DOI: 10.1039/B705805E  0.405
2007 Wojciechowski F, Hudson RH. Nucleobase modifications in peptide nucleic acids. Current Topics in Medicinal Chemistry. 7: 667-79. PMID 17430208 DOI: 10.2174/156802607780487795  0.76
2007 Pâtureau BM, Hudson RH, Damha MJ. Induction of RNase H activity by Arabinose-peptide nucleic acid chimeras. Bioconjugate Chemistry. 18: 421-30. PMID 17373768 DOI: 10.1021/Bc060300R  0.608
2006 Hudson R, Moszynski J. A Facile Synthesis of Fluorophores Based on 5-Phenylethynyluracils Synlett. 2006: 2997-3000. DOI: 10.1055/S-2006-948176  0.802
2005 Hudson RH, Wojciechowski F. Synthesis and properties of PNA oligomers containing orotic acid derivatives. Nucleosides, Nucleotides & Nucleic Acids. 24: 1123-6. PMID 16248105 DOI: 10.1081/Ncn-200065964  0.759
2005 Hudson RH, Dambenieks AK, Viirre RD. A direct synthesis of pyrrolocytosine from 5-iodocytosine. Nucleosides, Nucleotides & Nucleic Acids. 24: 581-4. PMID 16247992 DOI: 10.1081/Ncn-200061905  0.793
2003 Hudson RH, Viirre RD, McCourt N, Tse J. Nucleobase modified peptide nucleic acid. Nucleosides, Nucleotides & Nucleic Acids. 22: 1029-33. PMID 14565336 DOI: 10.1081/Ncn-120022728  0.773
2003 Hudson RH, Tse J. Towards a circular bis-peptide nucleic acid. Nucleosides, Nucleotides & Nucleic Acids. 22: 1023-7. PMID 14565335 DOI: 10.1081/Ncn-120022727  0.455
2003 Hudson RH, Viirre RD. Progress towards a submonomer synthesis of peptide nucleic acid. Nucleosides, Nucleotides & Nucleic Acids. 22: 1017-22. PMID 14565334 DOI: 10.1081/Ncn-120022726  0.462
2003 Viirre RD, Hudson RH. A convenient and scalable synthesis of ethyl N-[(2-Boc-amino)ethyl]glycinate and its hydrochloride. Key intermediates for peptide nucleic acid synthesis. The Journal of Organic Chemistry. 68: 1630-2. PMID 12585923 DOI: 10.1021/Jo026590W  0.804
2001 Viirre RD, Hudson RH. Optimization of a solid-phase synthesis of a PNA monomer. Organic Letters. 3: 3931-4. PMID 11720572 DOI: 10.1021/Ol016822Y  0.45
2001 Carriero S, Braich RS, Hudson RH, Anglin D, Friesen JD, Damha MJ. Inhibition of in vitro pre-mRNA splicing in S. cerevisiae by branched oligonucleotides. Nucleosides, Nucleotides & Nucleic Acids. 20: 873-7. PMID 11563135 DOI: 10.1081/Ncn-100002449  0.766
1998 Hudson RH, Robidoux S, Damha MJ. Divergent solid-phase synthesis of nucleic acid dendrimers Tetrahedron Letters. 39: 1299-1302. DOI: 10.1016/S0040-4039(97)10871-1  0.62
1997 Uddin AH, Piunno PA, Hudson RH, Damha MJ, Krull UJ. A fiber optic biosensor for fluorimetric detection of triple-helical DNA. Nucleic Acids Research. 25: 4139-46. PMID 9321670 DOI: 10.1093/Nar/25.20.4139  0.612
1997 Hudson RH, Poë AJ. Systematic CO dissociation kinetics of (μ2-H)(H)Os3(CO)10L, clusters (L = P-donor ligands) Inorganica Chimica Acta. 259: 257-263. DOI: 10.1016/S0020-1693(97)05466-2  0.602
1993 Damha MJ, Ganeshan K, Hudson RH, Zabarylo SV. Solid-phase synthesis of branched oligoribonucleotides related to messenger RNA splicing intermediates. Nucleic Acids Research. 20: 6565-73. PMID 1480476 DOI: 10.1093/Nar/20.24.6565  0.585
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