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Linda M. Columbus - Publications

Chemistry University of Virginia, Charlottesville, VA 
magnetic resonance, membrane proteins

79 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Necelis M, McDermott C, Belcher Dufrisne M, Baryiames C, Columbus L. Solution NMR investigations of integral membrane proteins: Challenges and innovations. Current Opinion in Structural Biology. 82: 102654. PMID 37542910 DOI: 10.1016/  0.791
2022 Keller TCS, Lechauve C, Keller AS, Broseghini-Filho GB, Butcher JT, Askew Page HR, Islam A, Tan ZY, DeLalio LJ, Brooks S, Sharma P, Hong K, Xu W, Padilha AS, Ruddiman CA, ... ... Columbus L, et al. Endothelial alpha globin is a nitrite reductase. Nature Communications. 13: 6405. PMID 36302779 DOI: 10.1038/s41467-022-34154-3  0.485
2021 Keller TCS, Lechauve C, Keller AS, Brooks S, Weiss MJ, Columbus L, Ackerman HC, Cortese-Krott MM, Isakson BE. The role of globins in cardiovascular physiology. Physiological Reviews. PMID 34486392 DOI: 10.1152/physrev.00037.2020  0.502
2020 Werner LM, Palmer A, Smirnov A, Dufrisne MB, Columbus L, Criss AK. Imaging Flow Cytometry Analysis of CEACAM Binding to Opa-Expressing Neisseria gonorrhoeae. Cytometry Part A. PMID 32484607 DOI: 10.1002/Cyto.A.24037  0.388
2020 Dufrisne MLB, Columbus LM. Functional and Structural Studies of Opa Proteins from Neisseria Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.1409  0.375
2020 Swope N, Seifert S, Columbus LM. Alpha-Helical Membrane Protein Folding in “Mixed” and “Ideal” Bicelles Biophysical Journal. 118: 226a. DOI: 10.1016/J.Bpj.2019.11.1340  0.404
2020 Caldwell TA, Vickery ON, Stansfeld PJ, Columbus L. Conformational Dynamics of the Membrane Enzyme LspA using EPR and MD Biophysical Journal. 118: 178a. DOI: 10.1016/J.Bpj.2019.11.1087  0.336
2019 Kieber M, Ono T, Oliver RC, Nyenhuis SB, Tieleman DP, Columbus L. The Fluidity of Phosphocholine and Maltoside Micelles and the Effect of CHAPS. Biophysical Journal. PMID 31735325 DOI: 10.1016/J.Bpj.2019.03.019  0.409
2019 Kuhn J, Smirnov A, Criss AK, Columbus L. Quantifying Carcinoembryonic Antigen-like Cell Adhesion Molecule-Targeted Liposome Delivery Using Imaging Flow Cytometry. Molecular Pharmaceutics. 16: 2354-2363. PMID 30995063 DOI: 10.1021/Acs.Molpharmaceut.8B01274  0.347
2019 Shu XH, Ruddiman CA, Keller TS, Keller AS, Yang Y, Good ME, Best AK, Columbus L, Isakson BE. Heterocellular Contact Can Dictate Arterial Function. Circulation Research. PMID 30900949 DOI: 10.1161/Circresaha.118.313926  0.522
2019 Stevenson Keller T, Isakson BE, Columbus L. Molecular Modeling of the Alpha Globin/eNOS Complex via Crosslinking Mass Spectrometry Biophysical Journal. 116: 168a. DOI: 10.1016/J.Bpj.2018.11.933  0.516
2019 Caldwell TA, Columbus L. Investigating the Conformational Dynamics of the Membrane Enzyme LspA Biophysical Journal. 116: 517a. DOI: 10.1016/J.Bpj.2018.11.2786  0.336
2019 Swope N, Columbus L. Impact of Lipid-Protein Interactions on Alpha-Helical Membrane Protein Fold Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.2020  0.45
2019 Martin JN, Criss AK, Columbus L. Molecular Determinants of Neisserial Opa Protein Interactions with Human CEACAMs Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.1888  0.377
2019 Ahn K, Caldwell TA, Columbus L. Solving the Structure of Inclusion Membrane Protein a in C. trachomatis Biophysical Journal. 116: 334a. DOI: 10.1016/J.Bpj.2018.11.1819  0.409
2018 Hays JM, Kieber MK, Li JZ, Han JI, Columbus L, Kasson P. Refinement of highly flexible protein structures using simulation-guided spectroscopy. Angewandte Chemie (International Ed. in English). PMID 30395378 DOI: 10.1002/Anie.201810462  0.379
2018 Caldwell T, Baoukina S, Brock AT, Oliver RC, Root KT, Kreuger JK, Glover KJ, Tieleman DP, Columbus L. Low q Bicelles are Mixed Micelles. The Journal of Physical Chemistry Letters. PMID 30024762 DOI: 10.1021/Acs.Jpclett.8B02079  0.336
2018 Hays JM, Kieber M, Columbus L, Kasson PM. Simulation-Guided Selection of Spectroscopic Experiments to Refine Highly Flexible Protein Structures Biophysical Journal. 114: 66a. DOI: 10.1016/J.Bpj.2017.11.407  0.337
2018 Columbus L. Differences Between Micelles, Bicelles, and Membranes and the Impact on Membrane Protein Structure Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.079  0.421
2017 Yang J, Zong Y, Su J, Li H, Zhu H, Columbus L, Zhou L, Liu Q. Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s. Nature Communications. 8: 1201. PMID 29084938 DOI: 10.1038/S41467-017-01310-Z  0.323
2017 Martin J, Kieber M, Columbus L. Investigation of Affinities and Structures of Membrane Protein-Protein Interactions using Comparable Samples Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.1931  0.468
2017 Stevenson Keller T, Swope NK, Isakson BE, Columbus L. Identification of Key Structural Features Determining the Binding of Alpha Globin and Endothelial Nitric Oxide Synthase Biophysical Journal. 112: 344a. DOI: 10.1016/J.Bpj.2016.11.1865  0.549
2017 Hays JM, Kieber M, Nyenhuis D, Columbus L, Cafiso D, Kasson P. Guiding Double Electron Electron Resonance Experiments using Information Theory and Molecular Dynamics Simulations Biophysical Journal. 112: 192a. DOI: 10.1016/J.Bpj.2016.11.1064  0.574
2016 Keller TC, Butcher JT, Broseghini-Filho GB, Marziano C, DeLalio LJ, Rogers S, Ning B, Martin JN, Chechova S, Cabot M, Shu X, Best AK, Good ME, Simão Padilha A, Purdy M, ... ... Columbus L, et al. Modulating Vascular Hemodynamics With an Alpha Globin Mimetic Peptide (HbαX). Hypertension (Dallas, Tex. : 1979). PMID 27802421 DOI: 10.1161/Hypertensionaha.116.08171  0.543
2016 Martin JN, Ball LM, Solomon TL, Dewald AH, Criss AK, Columbus L. Neisserial Opa protein - CEACAM interactions: competition for receptors as a means for bacterial invasion and pathogenesis. Biochemistry. PMID 27442026 DOI: 10.1021/Acs.Biochem.6B00124  0.779
2016 Martin J, Ball LM, Criss AK, Columbus L. Molecular Determinants of Neissserial Opa Protein Interactions with CEACAM Receptors Biophysical Journal. 110: 88a. DOI: 10.1016/J.Bpj.2015.11.533  0.421
2016 Hays JM, Kieber M, Solomon T, Columbus L, Kasson PM. Probing Conformational Equilibria in Flexible Recognition by Molecular Dynamics and EPR Biophysical Journal. 110: 57a. DOI: 10.1016/J.Bpj.2015.11.374  0.322
2016 Kuhn J, Smirnov A, Criss AK, Columbus L. Targeting Liposomes for Uptake into CEACAM-Expressing Human Cells using a Bacterial Membrane Protein Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.3165  0.382
2016 Brock A, Lipes S, Oliver R, Baoukina S, Tieleman P, Columbus L. Micelles and Bicelles as Membrane Mimics for Membrane Protein Characterization Biophysical Journal. 110: 571a-572a. DOI: 10.1016/J.Bpj.2015.11.3058  0.448
2016 Keller TS, Butcher JT, Isakson BE, Columbus LM. Molecular Competitors of the Alpha Globin/eNOS Interaction Biophysical Journal. 110: 541a. DOI: 10.1016/J.Bpj.2015.11.2897  0.562
2016 Kieber MK, Hays J, Solomon T, Kasson P, Columbus L. Neisserial Opa Protein Loop Dynamics and Mechanism of Interaction with Host CEACAM Receptors Biophysical Journal. 110: 221a. DOI: 10.1016/J.Bpj.2015.11.1227  0.448
2015 Shu X, Keller TC, Begandt D, Butcher JT, Biwer L, Keller AS, Columbus L, Isakson BE. Endothelial nitric oxide synthase in the microcirculation. Cellular and Molecular Life Sciences : Cmls. 72: 4561-75. PMID 26390975 DOI: 10.1007/S00018-015-2021-0  0.544
2015 Gray C, Price CW, Lee CT, Dewald AH, Cline MA, McAnany CE, Columbus L, Mura C. Known structure, unknown function: An inquiry-based undergraduate biochemistry laboratory course. Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology. PMID 26148241 DOI: 10.1002/Bmb.20873  0.715
2015 Columbus L. Post-expression strategies for structural investigations of membrane proteins. Current Opinion in Structural Biology. 32: 131-138. PMID 25951412 DOI: 10.1016/J.Sbi.2015.04.005  0.461
2015 Columbus L, Kroncke B. Solution NMR Structure Determination of Polytopic α-Helical Membrane Proteins: A Guide to Spin Label Paramagnetic Relaxation Enhancement Restraints. Methods in Enzymology. 557: 329-48. PMID 25950972 DOI: 10.1016/Bs.Mie.2014.12.005  0.72
2015 Johnson MB, Ball LM, Daily KP, Martin JN, Columbus L, Criss AK. Opa+ Neisseria gonorrhoeae exhibits reduced survival in human neutrophils via Src family kinase-mediated bacterial trafficking into mature phagolysosomes. Cellular Microbiology. 17: 648-65. PMID 25346239 DOI: 10.1111/Cmi.12389  0.307
2015 Kieber MK, Solomon T, Columbus L. Neisserial Opa Protein Dynamics and Interaction with Host Ceacam Receptors Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.531  0.435
2015 Columbus L. Tuning Micelle Dimensions and Properties for Stabilizing Membrane Protein Fold and Function Biophysical Journal. 108: 43a. DOI: 10.1016/J.Bpj.2014.11.266  0.452
2015 Brock A, Lipes S, Columbus L. Systematic Perturbations of Micelle Properties to Investigate the Stabilization of Membrane Protein Structure and Function Biophysical Journal. 108: 254a. DOI: 10.1016/J.Bpj.2014.11.1407  0.464
2015 Martin JN, Lo RH, Criss AK, Columbus L. Insights into the Specificity of Neisserial Opa Protein Interactions with Human Receptors Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.1114  0.438
2014 Oliver RC, Lipfert J, Fox DA, Lo RH, Kim JJ, Doniach S, Columbus L. Tuning micelle dimensions and properties with binary surfactant mixtures. Langmuir : the Acs Journal of Surfaces and Colloids. 30: 13353-61. PMID 25312254 DOI: 10.1021/La503458N  0.369
2014 Lo RH, Kroncke BM, Solomon TL, Columbus L. Mapping membrane protein backbone dynamics: a comparison of site-directed spin labeling with NMR 15N-relaxation measurements. Biophysical Journal. 107: 1697-702. PMID 25296323 DOI: 10.1016/J.Bpj.2014.08.018  0.739
2014 Straub AC, Butcher JT, Billaud M, Mutchler SM, Artamonov MV, Nguyen AT, Johnson T, Best AK, Miller MP, Palmer LA, Columbus L, Somlyo AV, Le TH, Isakson BE. Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 2594-600. PMID 25278292 DOI: 10.1016/J.Niox.2014.09.126  0.544
2014 Butcher JT, Johnson T, Beers J, Columbus L, Isakson BE. Hemoglobin α in the blood vessel wall. Free Radical Biology & Medicine. 73: 136-42. PMID 24832680 DOI: 10.1016/J.Freeradbiomed.2014.04.019  0.542
2014 Fox DA, Larsson P, Lo RH, Kroncke BM, Kasson PM, Columbus L. Structure of the Neisserial outer membrane protein Opa₆₀: loop flexibility essential to receptor recognition and bacterial engulfment. Journal of the American Chemical Society. 136: 9938-46. PMID 24813921 DOI: 10.1021/Ja503093Y  0.722
2014 Columbus L, Fox D, Larsson P, Lo R, Kroncke B, Kasson P. Solution Structure Of Opa60 From N. Gonorrhoeae Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Maf/Pdb  0.64
2014 Lo RH, Fox DA, Columbus L. Structure, Dynamics, and Receptor Binding of Opa Proteins Biophysical Journal. 106: 266a-267a. DOI: 10.1016/J.Bpj.2013.11.1561  0.499
2014 Brock AT, Columbus L. Influence of Detergent Properties on the Solubilization and Function of Membrane Proteins Biophysical Journal. 106: 222a. DOI: 10.1016/J.Bpj.2013.11.1298  0.451
2013 Li J, Liu Q, Xiao L, Haverstick DM, Dewald A, Columbus L, Kelly K, Landers JP. Label-free method for cell counting in crude biological samples via paramagnetic bead aggregation. Analytical Chemistry. 85: 11233-9. PMID 24187938 DOI: 10.1021/Ac401402H  0.74
2013 Fox DA, Columbus L. Solution NMR resonance assignment strategies for β-barrel membrane proteins. Protein Science : a Publication of the Protein Society. 22: 1133-40. PMID 23754333 DOI: 10.1002/Pro.2291  0.396
2013 Oliver RC, Lipfert J, Fox DA, Lo RH, Doniach S, Columbus L. Dependence of micelle size and shape on detergent alkyl chain length and head group. Plos One. 8: e62488. PMID 23667481 DOI: 10.1371/Journal.Pone.0062488  0.359
2013 Kroncke BM, Columbus L. Backbone ¹H, ¹³C and ¹⁵N resonance assignments of the α-helical membrane protein TM0026 from Thermotoga maritima. Biomolecular Nmr Assignments. 7: 203-6. PMID 23011877 DOI: 10.1007/S12104-012-9410-1  0.744
2013 Oliver RC, Lipfert J, Columbus L. Modulating the Physical Properties of Micelles for Membrane Protein Investigations Biophysical Journal. 104: 44a. DOI: 10.1016/J.Bpj.2012.11.282  0.42
2013 Fox DA, Columbus L. NMR Solution Structure of Opa60: A Neisserial Membrane Protein that Mediates Host Phagocytosis Biophysical Journal. 104: 179a-180a. DOI: 10.1016/J.Bpj.2012.11.1010  0.427
2012 Straub AC, Lohman AW, Billaud M, Johnstone SR, Dwyer ST, Lee MY, Bortz PS, Best AK, Columbus L, Gaston B, Isakson BE. Endothelial cell expression of haemoglobin α regulates nitric oxide signalling. Nature. 491: 473-7. PMID 23123858 DOI: 10.1038/Nature11626  0.549
2012 Johnstone SR, Kroncke BM, Straub AC, Best AK, Dunn CA, Mitchell LA, Peskova Y, Nakamoto RK, Koval M, Lo CW, Lampe PD, Columbus L, Isakson BE. MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation. Circulation Research. 111: 201-11. PMID 22652908 DOI: 10.1161/Circresaha.112.272302  0.725
2012 Kroncke BM, Columbus L. Identification and removal of nitroxide spin label contaminant: impact on PRE studies of α-helical membrane proteins in detergent. Protein Science : a Publication of the Protein Society. 21: 589-95. PMID 22389096 DOI: 10.1002/Pro.2038  0.738
2012 Columbus L, Fox DA, Lo RH. Strategies for the Solution NMR Structure Determination of Beta-Barrel Membrane Proteins Biophysical Journal. 102: 422a-423a. DOI: 10.1016/J.Bpj.2011.11.2311  0.431
2011 Dewald AH, Hodges JC, Columbus L. Physical determinants of β-barrel membrane protein folding in lipid vesicles. Biophysical Journal. 100: 2131-40. PMID 21539780 DOI: 10.1016/J.Bpj.2011.03.025  0.781
2011 Kroncke BM, Kim J, Columbus LM. Nitroxide Spin Label Side Chain Dynamics of Solvent Exposed Sites on Membrane Proteins Biophysical Journal. 100: 143a-144a. DOI: 10.1016/J.Bpj.2010.12.989  0.741
2011 Hodges JC, Dewald AH, Columbus L. The Characterization of the Binding of Opacity-Associated Proteins to Human Host Cell Receptors Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.3186  0.782
2011 Fox DA, Columbus L. NMR Backbone Assignment of Opai: A Mediator of Host:Neisseria Interactions Biophysical Journal. 100: 385a. DOI: 10.1016/J.Bpj.2010.12.2290  0.446
2011 Oliver R, Lo R, Kim J, Columbus L. Investigating the Relationship Between Physical Properties of Detergents and Membrane Protein Structure Determination Biophysical Journal. 100: 385a. DOI: 10.1016/J.Bpj.2010.12.2289  0.471
2011 Keller A, Columbus L. Structural Investigations of Inclusion Membrane Protein a (INCA) of Chlamydia Trachomatis Biophysical Journal. 100: 381a. DOI: 10.1016/J.Bpj.2010.12.2268  0.464
2010 Kroncke BM, Horanyi PS, Columbus L. Structural origins of nitroxide side chain dynamics on membrane protein α-helical sites. Biochemistry. 49: 10045-60. PMID 20964375 DOI: 10.1021/Bi101148W  0.736
2010 Beuck C, Szymczyna BR, Kerkow DE, Carmel AB, Columbus L, Stanfield RL, Williamson JR. Structure of the GLD-1 homodimerization domain: insights into STAR protein-mediated translational regulation. Structure (London, England : 1993). 18: 377-89. PMID 20223220 DOI: 10.1016/J.Str.2009.12.016  0.357
2010 Dewald AH, Hodges JC, Columbus L. The Spontaneous Refolding of Opacity-Associated Proteins into Lipid Membranes Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.3417  0.799
2009 Columbus L, Lipfert J, Jambunathan K, Fox DA, Sim AY, Doniach S, Lesley SA. Mixing and matching detergents for membrane protein NMR structure determination. Journal of the American Chemical Society. 131: 7320-6. PMID 19425578 DOI: 10.1021/Ja808776J  0.484
2009 Reyes C, Fox DA, Jambunathan K, Nguyen T, Bielnicka I, Columbus L. Molecular Determinants of Neisserial Pathogenesis: Mapping the Interaction Between Opa I and a Human Binding Partner CEACAM1 Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.3819  0.436
2008 McCleverty CJ, Columbus L, Kreusch A, Lesley SA. Structure and ligand binding of the soluble domain of a Thermotoga maritima membrane protein of unknown function TM1634. Protein Science : a Publication of the Protein Society. 17: 869-77. PMID 18369189 DOI: 10.1110/Ps.083432208  0.414
2007 Lipfert J, Columbus L, Chu VB, Lesley SA, Doniach S. Size and shape of detergent micelles determined by small-angle X-ray scattering. The Journal of Physical Chemistry. B. 111: 12427-38. PMID 17924686 DOI: 10.1021/Jp073016L  0.324
2006 Columbus L, Lipfert J, Klock H, Millett I, Doniach S, Lesley SA. Expression, purification, and characterization of Thermotoga maritima membrane proteins for structure determination. Protein Science : a Publication of the Protein Society. 15: 961-75. PMID 16597824 DOI: 10.1110/Ps.051874706  0.486
2005 Columbus L, Peti W, Etezady-Esfarjani T, Herrmann T, Wüthrich K. NMR structure determination of the conserved hypothetical protein TM1816 from Thermotoga maritima. Proteins. 60: 552-7. PMID 15937903 DOI: 10.1002/Prot.20465  0.638
2004 Columbus L, Hubbell WL. Mapping backbone dynamics in solution with site-directed spin labeling: GCN4-58 bZip free and bound to DNA. Biochemistry. 43: 7273-87. PMID 15182173 DOI: 10.1021/Bi0497906  0.554
2004 Liang Z, Lou Y, Freed JH, Columbus L, Hubbell WL. A multifrequency electron spin resonance study of T4 lysozyme dynamics using the slowly relaxing local Structure model Journal of Physical Chemistry B. 108: 17649-17659. DOI: 10.1021/Jp0484837  0.495
2002 Columbus L, Hubbell WL. A new spin on protein dynamics. Trends in Biochemical Sciences. 27: 288-95. PMID 12069788 DOI: 10.1016/S0968-0004(02)02095-9  0.617
2001 Columbus L, Kálai T, Jekö J, Hideg K, Hubbell WL. Molecular motion of spin labeled side chains in alpha-helices: analysis by variation of side chain structure. Biochemistry. 40: 3828-46. PMID 11300763 DOI: 10.1021/Bi002645H  0.541
2000 Gaponenko V, Howarth JW, Columbus L, Gasmi-Seabrook G, Yuan J, Hubbell WL, Rosevear PR. Protein global fold determination using site-directed spin and isotope labeling. Protein Science : a Publication of the Protein Society. 9: 302-9. PMID 10716182 DOI: 10.1110/Ps.9.2.302  0.576
1999 Gross A, Columbus L, Hideg K, Altenbach C, Hubbell WL. Structure of the KcsA potassium channel from Streptomyces lividans: a site-directed spin labeling study of the second transmembrane segment. Biochemistry. 38: 10324-35. PMID 10441126 DOI: 10.1021/Bi990856K  0.658
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