Thomas Wells Kensler - Publications

Affiliations: 
2010 Johns Hopkins University, Baltimore, MD 
 2010- Pharmacology & Chemical Biology University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Pharmacology, Biochemistry, Molecular Biology, Oncology
Website:
http://www.pharmacology.us/Faculty/ThomasKensler

271 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Tamatam CM, Reddy NM, Potteti HR, Ankireddy A, Noone PM, Yamamoto M, Kensler TW, Reddy SP. Preconditioning the immature lung with enhanced Nrf2 activity protects against oxidant-induced hypoalveolarization in mice. Scientific Reports. 10: 19034. PMID 33149211 DOI: 10.1038/s41598-020-75834-8  0.4
2020 Suzuki T, Uruno A, Yumoto A, Taguchi K, Suzuki M, Harada N, Ryoke R, Naganuma E, Osanai N, Goto A, Suda H, Browne R, Otsuki A, Katsuoka F, Zorzi M, ... ... Kensler TW, et al. Author Correction: Nrf2 contributes to the weight gain of mice during space travel. Communications Biology. 3: 566. PMID 33028949 DOI: 10.1038/s42003-020-01292-7  0.4
2020 Suzuki T, Uruno A, Yumoto A, Taguchi K, Suzuki M, Harada N, Ryoke R, Naganuma E, Osanai N, Goto A, Suda H, Browne R, Otsuki A, Katsuoka F, Zorzi M, ... ... Kensler TW, et al. Nrf2 contributes to the weight gain of mice during space travel. Communications Biology. 3: 496. PMID 32901092 DOI: 10.1038/s42003-020-01227-2  0.4
2020 Yagishita Y, McCallum ML, Kensler TW, Wakabayashi N. Constitutive Activation of Nrf2 in Mice Expands Enterogenesis in Small Intestine Through Negative Regulation of Math1. Cellular and Molecular Gastroenterology and Hepatology. PMID 32896624 DOI: 10.1016/j.jcmgh.2020.08.013  0.72
2020 Rush BM, Bondi CD, Stocker SD, Barry KM, Small SA, Ong J, Jobbagy S, Stolz DB, Bastacky SI, Chartoumpekis DV, Kensler TW, Tan RJ. Genetic or Pharmacologic Nrf2 Activation Increases Proteinuria in Chronic Kidney Disease in Mice. Kidney International. PMID 32818518 DOI: 10.1016/j.kint.2020.07.036  0.4
2020 Palliyaguru DL, Yang L, Chartoumpekis DV, Wendell SG, Fazzari M, Skoko JJ, Liao Y, Oesterreich S, Michalopoulos GK, Kensler TW. Sulforaphane Diminishes the Formation of Mammary Tumors in Rats Exposed to 17β-Estradiol. Nutrients. 12. PMID 32751496 DOI: 10.3390/nu12082282  0.72
2019 Taguchi K, Kensler TW. Nrf2 in liver toxicology. Archives of Pharmacal Research. PMID 31782059 DOI: 10.1007/s12272-019-01192-3  0.4
2019 Yagishita Y, Fahey JW, Dinkova-Kostova AT, Kensler TW. Broccoli or Sulforaphane: Is It the Source or Dose That Matters? Molecules (Basel, Switzerland). 24. PMID 31590459 DOI: 10.3390/molecules24193593  0.32
2019 Livingstone MC, Johnson NM, Roebuck BD, Kensler TW, Groopman JD. Serum miR-182 is a predictive biomarker for dichotomization of risk of hepatocellular carcinoma in rats. Molecular Carcinogenesis. PMID 31373075 DOI: 10.1002/mc.23093  1
2019 Chen JG, Johnson J, Egner P, Ng D, Zhu J, Wang JB, Xue XF, Sun Y, Zhang YH, Lu LL, Chen YS, Wu Y, Zhu YR, Carmella S, Hecht S, ... ... Kensler T, et al. Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China. The American Journal of Clinical Nutrition. PMID 31268126 DOI: 10.1093/ajcn/nqz122  0.4
2019 Paunkov A, Chartoumpekis DV, Ziros PG, Chondrogianni N, Kensler TW, Sykiotis GP. Impact of Antioxidant Natural Compounds on the Thyroid Gland and Implication of the Keap1/Nrf2 Signaling Pathway. Current Pharmaceutical Design. PMID 31267862 DOI: 10.2174/1381612825666190701165821  0.4
2019 Chen J, Zhu J, Wang G, Groopman JD, Kensler TW. Qidong: a crucible for studies on liver cancer etiology and prevention. Cancer Biology & Medicine. 16: 24-37. PMID 31119044 DOI: 10.20892/j.issn.2095-3941.2018.0394  1
2019 Chartoumpekis DV, Ziros PG, Chen JG, Groopman JD, Kensler TW, Sykiotis GP. Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. PMID 30735751 DOI: 10.1016/j.fct.2019.02.004  1
2019 Yagishita Y, Uruno A, Chartoumpekis DV, Kensler TW, Yamamoto M. Nrf2 represses the onset of type 1 diabetes in non-obese diabetic mice. The Journal of Endocrinology. PMID 30625116 DOI: 10.1530/JOE-18-0355  0.4
2018 Lippman SM, Abate-Shen C, Colbert Maresso KL, Colditz GA, Dannenberg AJ, Davidson NE, Disis ML, DuBois RN, Szabo E, Giuliano AR, Hait WN, Lee JJ, Kensler TW, Kramer BS, Limburg P, et al. AACR White Paper: Shaping the Future of Cancer Prevention - A Roadmap for Advancing Science and Public Health. Cancer Prevention Research (Philadelphia, Pa.). 11: 735-778. PMID 30530635 DOI: 10.1158/1940-6207.CAPR-18-0421  1
2018 Ziros PG, Habeos I, Chartoumpekis DV, Ntalampyra E, Somm E, Renaud CO, Bongiovanni M, Trougakos IP, Yamamoto M, Kensler TW, Santisteban P, Carrasco N, Ris-Stalpers C, Amendola E, Liao XH, et al. The NFE2-related transcription factor 2 (Nrf2) coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland. Thyroid : Official Journal of the American Thyroid Association. PMID 29742982 DOI: 10.1089/thy.2018.0018  0.4
2018 Yamamoto M, Kensler TW, Motohashi H. The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis. Physiological Reviews. 98: 1169-1203. PMID 29717933 DOI: 10.1152/physrev.00023.2017  0.4
2018 Chartoumpekis DV, Yagishita Y, Fazzari M, Palliyaguru DL, Rao UN, Zaravinos A, Khoo NK, Schopfer FJ, Weiss KR, Michalopoulos GK, Sipula I, O'Doherty RM, Kensler TW, Wakabayashi N. Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice. Jci Insight. 3. PMID 29515034 DOI: 10.1172/jci.insight.97735  0.72
2018 Chartoumpekis DV, Palliyaguru DL, Wakabayashi N, Fazzari M, Khoo NK, Schopfer FJ, Sipula I, Yagishita Y, Michalopoulos GK, O'Doherty RM, Kensler TW. Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice. American Journal of Physiology. Endocrinology and Metabolism. PMID 29486138 DOI: 10.1152/ajpendo.00311.2017  0.72
2018 Wible RS, Ramanathan C, Sutter CH, Olesen KM, Kensler TW, Liu AC, Sutter TR. NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in. Elife. 7. PMID 29481323 DOI: 10.7554/eLife.31656  0.44
2018 Chen T, Qian G, Fan C, Sun Y, Wang J, Lu P, Xue X, Wu Y, Zhang Q, Jin Y, Wu Y, Gan Y, Lu J, Kensler TW, Groopman JD, et al. Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer. Hepatoma Research. 4. PMID 29479565 DOI: 10.20517/2394-5079.2017.50  1
2018 Palliyaguru DL, Yuan JM, Kensler TW, Fahey JW. Isothiocyanates: Translating the Power of Plants to People. Molecular Nutrition & Food Research. PMID 29468815 DOI: 10.1002/mnfr.201700965  0.32
2018 Wible RS, Tran QT, Fathima S, Sutter CH, Kensler TW, Sutter TR. Pharmacogenomics of chemically distinct classes of Keap1-Nrf2 activators identify common and unique gene, protein, and pathway responses in vivo. Molecular Pharmacology. PMID 29367259 DOI: 10.1124/mol.117.110262  0.44
2017 Dinkova-Kostova AT, Fahey JW, Kostov RV, Kensler TW. KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane. Trends in Food Science & Technology. 69: 257-269. PMID 29242678 DOI: 10.1016/j.tifs.2017.02.002  0.32
2017 Reddy NM, Kleeberger SR, Kensler TW, Yamamoto M, Hassoun PM, Reddy SP. Correction: Disruption of Nrf2 Impairs the Resolution of Hyperoxia-Induced Acute Lung Injury and Inflammation in Mice. Journal of Immunology (Baltimore, Md. : 1950). 198: 3755. PMID 28416718 DOI: 10.4049/jimmunol.1700291  0.4
2017 Copple IM, Dinkova-Kostova AT, Kensler TW, Liby KT, Wigley WC. NRF2 as an Emerging Therapeutic Target. Oxidative Medicine and Cellular Longevity. 2017: 8165458. PMID 28250892 DOI: 10.1155/2017/8165458  0.4
2017 Livingstone MC, Johnson NM, Roebuck BD, Kensler TW, Groopman JD. Profound changes in miRNA expression during cancer initiation by aflatoxin B1 and their abrogation by the chemopreventive triterpenoid CDDO-Im. Molecular Carcinogenesis. PMID 28218475 DOI: 10.1002/mc.22635  1
2016 Tan RJ, Chartoumpekis DV, Rush BM, Zhou D, Fu H, Kensler TW, Liu Y. Keap1 hypomorphism protects against ischemic and obstructive kidney disease. Scientific Reports. 6: 36185. PMID 27804998 DOI: 10.1038/srep36185  0.4
2016 Palliyaguru DL, Chartoumpekis DV, Wakabayashi N, Skoko JJ, Yagishita Y, Singh SV, Kensler TW. Withaferin A induces Nrf2-dependent protection against liver injury: role of Keap1-independent mechanisms. Free Radical Biology & Medicine. PMID 27717869 DOI: 10.1016/j.freeradbiomed.2016.10.003  1
2016 Davidson NE, Armstrong SA, Coussens LM, Cruz-Correa MR, DeBerardinis RJ, Doroshow JH, Foti M, Hwu P, Kensler TW, Morrow M, Mulligan CG, Pao W, Platz EA, Smith TJ, Willman CL. AACR Cancer Progress Report 2016. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 22: S1-S137. PMID 27697776 DOI: 10.1158/1078-0432.CCR-16-1993  1
2016 Bauman JE, Zang Y, Sen M, Li C, Wang L, Egner PA, Fahey JW, Normolle DP, Grandis JR, Kensler TW, Johnson DE. Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane. Cancer Prevention Research (Philadelphia, Pa.). PMID 27339168 DOI: 10.1158/1940-6207.CAPR-15-0290  1
2016 Taguchi K, Takaku M, Egner PA, Morita M, Kaneko T, Mashimo T, Kensler TW, Yamamoto M. Generation of A New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27071940 DOI: 10.1093/toxsci/kfw065  1
2016 Yang L, Palliyaguru DL, Kensler TW. Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane. Seminars in Oncology. 43: 146-53. PMID 26970133 DOI: 10.1053/j.seminoncol.2015.09.013  0.32
2016 Shelar SB, Narasimhan M, Shanmugam G, Litovsky SH, Gounder SS, Karan G, Arulvasu C, Kensler TW, Hoidal JR, Darley-Usmar VM, Rajasekaran NS. Disruption of nuclear factor (erythroid-derived-2)-like 2 antioxidant signaling: a mechanism for impaired activation of stem cells and delayed regeneration of skeletal muscle. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26839378 DOI: 10.1096/fj.201500153  1
2016 Kensler TW, Spira A, Garber JE, Szabo E, Lee JJ, Dong Z, Dannenberg AJ, Hait WN, Blackburn E, Davidson NE, Foti M, Lippman SM. Transforming Cancer Prevention through Precision Medicine and Immune-oncology. Cancer Prevention Research (Philadelphia, Pa.). 9: 2-10. PMID 26744449 DOI: 10.1158/1940-6207.CAPR-15-0406  1
2016 Meyskens FL, Mukhtar H, Rock CL, Cuzick J, Kensler TW, Yang CS, Ramsey SD, Lippman SM, Alberts DS. Cancer Prevention: Obstacles, Challenges and the Road Ahead. Journal of the National Cancer Institute. 108. PMID 26547931 DOI: 10.1093/jnci/djv309  1
2015 Slocum SL, Skoko JJ, Wakabayashi N, Aja S, Yamamoto M, Kensler TW, Chartoumpekis DV. Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet. Archives of Biochemistry and Biophysics. PMID 26701603 DOI: 10.1016/j.abb.2015.11.040  0.96
2015 Chartoumpekis DV, Wakabayashi N, Kensler TW. Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism. Biochemical Society Transactions. 43: 639-44. PMID 26551705 DOI: 10.1042/BST20150049  0.72
2015 Yang J, Zhu J, Zhang YH, Chen YS, Ding LL, Kensler TW, Chen JG. Lung Cancer in a Rural Area of China: Rapid Rise in Incidence and Poor Improvement in Survival. Asian Pacific Journal of Cancer Prevention : Apjcp. 16: 7295-302. PMID 26514527  0.4
2015 Chartoumpekis DV, Palliyaguru DL, Wakabayashi N, Khoo NK, Schoiswohl G, O'Doherty RM, Kensler TW. Notch intracellular domain overexpression in adipocytes confers lipodystrophy in mice. Molecular Metabolism. 4: 543-50. PMID 26137442 DOI: 10.1016/j.molmet.2015.04.004  1
2015 Wakabayashi N, Chartoumpekis DV, Kensler TW. Crosstalk between Nrf2 and Notch signaling. Free Radical Biology & Medicine. 88: 158-67. PMID 26003520 DOI: 10.1016/j.freeradbiomed.2015.05.017  0.72
2015 Sheth SH, Johnson DE, Kensler TW, Bauman JE. Chemoprevention targets for tobacco-related head and neck cancer: past lessons and future directions. Oral Oncology. 51: 557-64. PMID 25868717 DOI: 10.1016/j.oraloncology.2015.02.101  1
2014 Wu F, Mitchell NJ, Male D, Kensler TW. Reduced foodborne toxin exposure is a benefit of improving dietary diversity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 141: 329-34. PMID 25015663 DOI: 10.1093/toxsci/kfu137  1
2014 Skoko JJ, Wakabayashi N, Noda K, Kimura S, Tobita K, Shigemura N, Tsujita T, Yamamoto M, Kensler TW. Loss of Nrf2 in mice evokes a congenital intrahepatic shunt that alters hepatic oxygen and protein expression gradients and toxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 141: 112-9. PMID 24924401 DOI: 10.1093/toxsci/kfu109  0.72
2014 Egner PA, Chen JG, Zarth AT, Ng DK, Wang JB, Kensler KH, Jacobson LP, Muñoz A, Johnson JL, Groopman JD, Fahey JW, Talalay P, Zhu J, Chen TY, Qian GS, ... ... Kensler TW, et al. Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. Cancer Prevention Research (Philadelphia, Pa.). 7: 813-23. PMID 24913818 DOI: 10.1158/1940-6207.CAPR-14-0103  1
2014 Kensler KH, Slocum SL, Chartoumpekis DV, Dolan PM, Johnson NM, Ilic Z, Crawford DR, Sell S, Groopman JD, Kensler TW, Egner PA. Genetic or pharmacologic activation of Nrf2 signaling fails to protect against aflatoxin genotoxicity in hypersensitive GSTA3 knockout mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 139: 293-300. PMID 24675090 DOI: 10.1093/toxsci/kfu056  1
2014 Johnson NM, Egner PA, Baxter VK, Sporn MB, Wible RS, Sutter TR, Groopman JD, Kensler TW, Roebuck BD. Complete protection against aflatoxin B(1)-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature, and genotoxicity threshold. Cancer Prevention Research (Philadelphia, Pa.). 7: 658-65. PMID 24662598 DOI: 10.1158/1940-6207.CAPR-13-0430  1
2014 Wakabayashi N, Skoko JJ, Chartoumpekis DV, Kimura S, Slocum SL, Noda K, Palliyaguru DL, Fujimuro M, Boley PA, Tanaka Y, Shigemura N, Biswal S, Yamamoto M, Kensler TW. Notch-Nrf2 axis: regulation of Nrf2 gene expression and cytoprotection by notch signaling. Molecular and Cellular Biology. 34: 653-63. PMID 24298019 DOI: 10.1128/MCB.01408-13  1
2014 Chen JG, Kensler TW. Changing rates for liver and lung cancers in Qidong, China. Chemical Research in Toxicology. 27: 3-6. PMID 24215631 DOI: 10.1021/tx400313j  1
2014 Liu M, Reddy NM, Higbee EM, Potteti HR, Noel S, Racusen L, Kensler TW, Sporn MB, Reddy SP, Rabb H. The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia-reperfusion injury in mice. Kidney International. 85: 134-41. PMID 24088953 DOI: 10.1038/ki.2013.357  1
2013 Chen JG, Egner PA, Ng D, Jacobson LP, Muñoz A, Zhu YR, Qian GS, Wu F, Yuan JM, Groopman JD, Kensler TW. Reduced aflatoxin exposure presages decline in liver cancer mortality in an endemic region of China. Cancer Prevention Research (Philadelphia, Pa.). 6: 1038-45. PMID 23963804 DOI: 10.1158/1940-6207.CAPR-13-0168  1
2013 Vitturi DA, Chen CS, Woodcock SR, Salvatore SR, Bonacci G, Koenitzer JR, Stewart NA, Wakabayashi N, Kensler TW, Freeman BA, Schopfer FJ. Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase. The Journal of Biological Chemistry. 288: 25626-37. PMID 23878198 DOI: 10.1074/jbc.M113.486282  1
2013 Yang L, Zahid M, Liao Y, Rogan EG, Cavalieri EL, Davidson NE, Yager JD, Visvanathan K, Groopman JD, Kensler TW. Reduced formation of depurinating estrogen-DNA adducts by sulforaphane or KEAP1 disruption in human mammary epithelial MCF-10A cells. Carcinogenesis. 34: 2587-92. PMID 23843041 DOI: 10.1093/carcin/bgt246  1
2013 Kannan S, Muthusamy VR, Whitehead KJ, Wang L, Gomes AV, Litwin SE, Kensler TW, Abel ED, Hoidal JR, Rajasekaran NS. Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy. Cardiovascular Research. 100: 63-73. PMID 23761402 DOI: 10.1016/J.FREERADBIOMED.2013.10.593  1
2013 Uruno A, Furusawa Y, Yagishita Y, Fukutomi T, Muramatsu H, Negishi T, Sugawara A, Kensler TW, Yamamoto M. The Keap1-Nrf2 system prevents onset of diabetes mellitus. Molecular and Cellular Biology. 33: 2996-3010. PMID 23716596 DOI: 10.1128/MCB.00225-13  0.4
2013 Volonte D, Liu Z, Musille PM, Stoppani E, Wakabayashi N, Di YP, Lisanti MP, Kensler TW, Galbiati F. Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence. Molecular Biology of the Cell. 24: 1852-62. PMID 23637463 DOI: 10.1091/mbc.E12-09-0666  1
2013 Fahey JW, Kensler TW. Health span extension through green chemoprevention. The Virtual Mentor : Vm. 15: 311-8. PMID 23566780 DOI: 10.1001/virtualmentor.2013.15.4.stas1-1304  0.32
2013 Kawamura T, Wakabayashi N, Shigemura N, Huang CS, Masutani K, Tanaka Y, Noda K, Peng X, Takahashi T, Billiar TR, Okumura M, Toyoda Y, Kensler TW, Nakao A. Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. American Journal of Physiology. Lung Cellular and Molecular Physiology. 304: L646-56. PMID 23475767 DOI: 10.1152/ajplung.00164.2012  0.72
2013 Chartoumpekis DV, Kensler TW. New player on an old field; the keap1/Nrf2 pathway as a target for treatment of type 2 diabetes and metabolic syndrome. Current Diabetes Reviews. 9: 137-45. PMID 23363332  0.4
2013 Kensler TW, Egner PA, Agyeman AS, Visvanathan K, Groopman JD, Chen JG, Chen TY, Fahey JW, Talalay P. Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane. Topics in Current Chemistry. 329: 163-77. PMID 22752583 DOI: 10.1007/128_2012_339  1
2013 Kaidery NA, Banerjee R, Yang L, Smirnova NA, Hushpulian DM, Liby KT, Williams CR, Yamamoto M, Kensler TW, Ratan RR, Sporn MB, Beal MF, Gazaryan IG, Thomas B. Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease. Antioxidants & Redox Signaling. 18: 139-57. PMID 22746536 DOI: 10.1089/ars.2011.4491  1
2013 Strickland PT, Kensler TW. Environmental Factors Abeloff's Clinical Oncology: Fifth Edition. 127-141.e1. DOI: 10.1016/B978-1-4557-2865-7.00009-6  1
2012 Takaya K, Suzuki T, Motohashi H, Onodera K, Satomi S, Kensler TW, Yamamoto M. Validation of the multiple sensor mechanism of the Keap1-Nrf2 system Free Radical Biology and Medicine. 53: 817-827. PMID 22732183 DOI: 10.1016/j.freeradbiomed.2012.06.023  1
2012 Kageyama Y, Zhang Z, Roda R, Fukaya M, Wakabayashi J, Wakabayashi N, Kensler TW, Reddy PH, Iijima M, Sesaki H. Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage. The Journal of Cell Biology. 197: 535-51. PMID 22564413 DOI: 10.1083/jcb.201110034  0.72
2012 Meher AK, Sharma PR, Lira VA, Yamamoto M, Kensler TW, Yan Z, Leitinger N. Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance. Free Radical Biology & Medicine. 52: 1708-15. PMID 22370093 DOI: 10.1016/j.freeradbiomed.2012.02.022  1
2012 Weerachayaphorn J, Mennone A, Soroka CJ, Harry K, Hagey LR, Kensler TW, Boyer JL. Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine. American Journal of Physiology. Gastrointestinal and Liver Physiology. 302: G925-36. PMID 22345550 DOI: 10.1152/ajpgi.00263.2011  1
2012 Fahey JW, Wehage SL, Holtzclaw WD, Kensler TW, Egner PA, Shapiro TA, Talalay P. Protection of humans by plant glucosinolates: Efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora Cancer Prevention Research. 5: 603-611. PMID 22318753 DOI: 10.1158/1940-6207.CAPR-11-0538  1
2012 Fahey JW, Talalay P, Kensler TW. Notes from the field: "Green" chemoprevention as frugal medicine Cancer Prevention Research. 5: 179-188. PMID 22307565 DOI: 10.1158/1940-6207.CAPR-11-0572  1
2012 Kensler TW, Ng D, Carmella SG, Chen M, Jacobson LP, Muñoz A, Egner PA, Chen JG, Qian GS, Chen TY, Fahey JW, Talalay P, Groopman JD, Yuan JM, Hecht SS. Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China. Carcinogenesis. 33: 101-7. PMID 22045030 DOI: 10.1093/carcin/bgr229  1
2012 Wogan GN, Kensler TW, Groopman JD. Present and future directions of translational research on aflatoxin and hepatocellular carcinoma. A review. Food Additives & Contaminants. Part a, Chemistry, Analysis, Control, Exposure & Risk Assessment. 29: 249-57. PMID 21623489 DOI: 10.1080/19440049.2011.563370  1
2012 Agyeman AS, Chaerkady R, Shaw PG, Davidson NE, Visvanathan K, Pandey A, Kensler TW. Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles. Breast Cancer Research and Treatment. 132: 175-87. PMID 21597922 DOI: 10.1007/s10549-011-1536-9  1
2012 Kensler TW, Groopman JD, Egner PA, Muñoz A, Qian G, Chen J. Chemoprevention of hepatic cancer in aflatoxin endemic areas Primary Liver Cancer: Challenges and Perspectives. 2147483647: 339-365. DOI: 10.1007/978-3-642-28702-2_11  1
2011 Tolstov YL, Knauer A, Chen JG, Kensler TW, Kingsley LA, Moore PS, Chang Y. Asymptomatic primary Merkel cell polyomavirus infection among adults. Emerging Infectious Diseases. 17: 1371-80. PMID 21801612 DOI: 10.3201/eid1708.110079  1
2011 Davidson NE, Kensler TW. "MAPping" the course of chemoprevention in breast cancer. The New England Journal of Medicine. 364: 2463-4. PMID 21639807 DOI: 10.1056/NEJMe1106052  1
2011 Zhang Z, Wakabayashi N, Wakabayashi J, Tamura Y, Song WJ, Sereda S, Clerc P, Polster BM, Aja SM, Pletnikov MV, Kensler TW, Shirihai OS, Iijima M, Hussain MA, Sesaki H. The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells. Molecular Biology of the Cell. 22: 2235-45. PMID 21551073 DOI: 10.1091/mbc.E10-12-0933  1
2011 Muñoz A, Chen JG, Egner PA, Marshall ML, Johnson JL, Schneider MF, Lu JH, Zhu YR, Wang JB, Chen TY, Kensler TW, Groopman JD. Predictive power of hepatitis B 1762T/1764A mutations in plasma for hepatocellular carcinoma risk in Qidong, China. Carcinogenesis. 32: 860-5. PMID 21474708 DOI: 10.1093/carcin/bgr055  1
2011 Egner PA, Chen JG, Wang JB, Wu Y, Sun Y, Lu JH, Zhu J, Zhang YH, Chen YS, Friesen MD, Jacobson LP, Muñoz A, Ng D, Qian GS, Zhu YR, ... ... Kensler TW, et al. Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China. Cancer Prevention Research (Philadelphia, Pa.). 4: 384-95. PMID 21372038 DOI: 10.1158/1940-6207.CAPR-10-0296  1
2011 Slocum SL, Kensler TW. Nrf2: control of sensitivity to carcinogens. Archives of Toxicology. 85: 273-84. PMID 21369766 DOI: 10.1007/s00204-011-0675-4  1
2011 You A, Nam CW, Wakabayashi N, Yamamoto M, Kensler TW, Kwak MK. Transcription factor Nrf2 maintains the basal expression of Mdm2: An implication of the regulation of p53 signaling by Nrf2. Archives of Biochemistry and Biophysics. 507: 356-64. PMID 21211512 DOI: 10.1016/j.abb.2010.12.034  1
2011 Kensler TW, Roebuck BD, Wogan GN, Groopman JD. Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology. Toxicological Sciences : An Official Journal of the Society of Toxicology. 120: S28-48. PMID 20881231 DOI: 10.1093/toxsci/kfq283  1
2010 Kadl A, Meher AK, Sharma PR, Lee MY, Doran AC, Johnstone SR, Elliott MR, Gruber F, Han J, Chen W, Kensler T, Ravichandran KS, Isakson BE, Wamhoff BR, Leitinger N. Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2. Circulation Research. 107: 737-46. PMID 20651288 DOI: 10.1161/CIRCRESAHA.109.215715  1
2010 Wakabayashi N, Shin S, Slocum SL, Agoston ES, Wakabayashi J, Kwak MK, Misra V, Biswal S, Yamamoto M, Kensler TW. Regulation of notch1 signaling by nrf2: implications for tissue regeneration. Science Signaling. 3: ra52. PMID 20628156 DOI: 10.1126/scisignal.2000762  1
2010 Yao Y, Brodie AM, Davidson NE, Kensler TW, Zhou Q. Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer. Breast Cancer Research and Treatment. 124: 585-91. PMID 20623181 DOI: 10.1007/s10549-010-1023-8  1
2010 Malhotra D, Portales-Casamar E, Singh A, Srivastava S, Arenillas D, Happel C, Shyr C, Wakabayashi N, Kensler TW, Wasserman WW, Biswal S. Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis. Nucleic Acids Research. 38: 5718-34. PMID 20460467 DOI: 10.1093/nar/gkq212  0.72
2010 Shah ZA, Li RC, Ahmad AS, Kensler TW, Yamamoto M, Biswal S, Doré S. The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 30: 1951-61. PMID 20442725 DOI: 10.1038/jcbfm.2014.10  1
2010 Wakabayashi N, Slocum SL, Skoko JJ, Shin S, Kensler TW. When NRF2 talks, who's listening? Antioxidants & Redox Signaling. 13: 1649-63. PMID 20367496 DOI: 10.1089/ars.2010.3216  1
2010 Shin DH, Park HM, Jung KA, Choi HG, Kim JA, Kim DD, Kim SG, Kang KW, Ku SK, Kensler TW, Kwak MK. The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis. Free Radical Biology & Medicine. 48: 1051-63. PMID 20096777 DOI: 10.1016/j.freeradbiomed.2010.01.021  1
2010 Zhou Q, Chaerkady R, Shaw PG, Kensler TW, Pandey A, Davidson NE. Screening for therapeutic targets of vorinostat by SILAC-based proteomic analysis in human breast cancer cells. Proteomics. 10: 1029-39. PMID 20049865 DOI: 10.1002/pmic.200900602  1
2010 Kensler TW, Wakabayashi N. Nrf2: friend or foe for chemoprevention? Carcinogenesis. 31: 90-9. PMID 19793802 DOI: 10.1093/carcin/bgp231  0.72
2010 Kwak MK, Kensler TW. Targeting NRF2 signaling for cancer chemoprevention. Toxicology and Applied Pharmacology. 244: 66-76. PMID 19732782 DOI: 10.1016/j.taap.2009.08.028  0.44
2010 Gruber F, Mayer H, Lengauer B, Mlitz V, Sanders JM, Kadl A, Bilban M, de Martin R, Wagner O, Kensler TW, Yamamoto M, Leitinger N, Tschachler E. NF-E2-related factor 2 regulates the stress response to UVA-1-oxidized phospholipids in skin cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 39-48. PMID 19720622 DOI: 10.1096/fj.09-133520  1
2010 Groopman JD, Kensler TW. Food safety | Mycotoxins Encyclopedia of Human Nutrition. 317-323. DOI: 10.1016/B0-12-226694-3/00134-4  1
2009 Kensler TW, Groopman JD. Is it time to advance the chemoprevention of environmental carcinogenesis with microdosing trials? Cancer Prevention Research (Philadelphia, Pa.). 2: 1003-7. PMID 19952364 DOI: 10.1158/1940-6207.CAPR-09-0232  1
2009 Holland R, Navamal M, Velayutham M, Zweier JL, Kensler TW, Fishbein JC. Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones. Chemical Research in Toxicology. 22: 1427-34. PMID 19785463 DOI: 10.1021/tx900110n  1
2009 Wakabayashi J, Zhang Z, Wakabayashi N, Tamura Y, Fukaya M, Kensler TW, Iijima M, Sesaki H. The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. The Journal of Cell Biology. 186: 805-16. PMID 19752021 DOI: 10.1083/jcb.200903065  0.72
2009 Reddy NM, Suryanarayana V, Kalvakolanu DV, Yamamoto M, Kensler TW, Hassoun PM, Kleeberger SR, Reddy SP. Innate immunity against bacterial infection following hyperoxia exposure is impaired in NRF2-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 183: 4601-8. PMID 19734219 DOI: 10.4049/jimmunol.0901754  1
2009 Shin S, Wakabayashi J, Yates MS, Wakabayashi N, Dolan PM, Aja S, Liby KT, Sporn MB, Yamamoto M, Kensler TW. Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide. European Journal of Pharmacology. 620: 138-44. PMID 19698707 DOI: 10.1016/j.ejphar.2009.08.022  1
2009 Reddy NM, Suryanaraya V, Yates MS, Kleeberger SR, Hassoun PM, Yamamoto M, Liby KT, Sporn MB, Kensler TW, Reddy SP. The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice. American Journal of Respiratory and Critical Care Medicine. 180: 867-74. PMID 19679692 DOI: 10.1164/rccm.200905-0670OC  1
2009 Usera AR, Dolan P, Kensler TW, Posner GH. 'Novel alkyl side chain sulfone 1α,25-dihydroxyvitamin D3 analogs: A comparison of in vitro antiproliferative activities and in vivo calcemic activities' Bioorganic and Medicinal Chemistry. 17: 5627-5631. PMID 19577932 DOI: 10.1016/j.bmc.2009.06.033  1
2009 Reddy NM, Kleeberger SR, Kensler TW, Yamamoto M, Hassoun PM, Reddy SP. Disruption of Nrf2 impairs the resolution of hyperoxia-induced acute lung injury and inflammation in mice. Journal of Immunology (Baltimore, Md. : 1950). 182: 7264-71. PMID 19454723 DOI: 10.4049/jimmunol.0804248  1
2009 Nagai N, Thimmulappa RK, Cano M, Fujihara M, Izumi-Nagai K, Kong X, Sporn MB, Kensler TW, Biswal S, Handa JT. Nrf2 is a critical modulator of the innate immune response in a model of uveitis. Free Radical Biology & Medicine. 47: 300-6. PMID 19410644 DOI: 10.1016/j.freeradbiomed.2009.04.033  0.4
2009 Yates MS, Tran QT, Dolan PM, Osburn WO, Shin S, McCulloch CC, Silkworth JB, Taguchi K, Yamamoto M, Williams CR, Liby KT, Sporn MB, Sutter TR, Kensler TW. Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. Carcinogenesis. 30: 1024-31. PMID 19386581 DOI: 10.1093/carcin/bgp100  1
2009 Blackford A, Parmigiani G, Kensler TW, Wolfgang C, Jones S, Zhang X, Parsons DW, Lin JCH, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Klein A, et al. Genetic mutations associated with Cigarette smoking in pancreatic cancer Cancer Research. 69: 3681-3688. PMID 19351817 DOI: 10.1158/0008-5472.CAN-09-0015  1
2009 An SS, Kim J, Ahn K, Trepat X, Drake KJ, Kumar S, Ling G, Purington C, Rangasamy T, Kensler TW, Mitzner W, Fredberg JJ, Biswal S. Cell stiffness, contractile stress and the role of extracellular matrix. Biochemical and Biophysical Research Communications. 382: 697-703. PMID 19327344 DOI: 10.1016/j.bbrc.2009.03.118  0.4
2009 Roebuck BD, Johnson DN, Sutter CH, Egner PA, Scholl PF, Friesen MD, Baumgartner KJ, Ware NM, Bodreddigari S, Groopman JD, Kensler TW, Sutter TR. Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat. Toxicological Sciences : An Official Journal of the Society of Toxicology. 109: 41-9. PMID 19168568 DOI: 10.1093/toxsci/kfp003  1
2009 Tran QT, Xu L, Phan V, Goodwin SB, Rahman M, Jin VX, Sutter CH, Roebuck BD, Kensler TW, George EO, Sutter TR. Chemical genomics of cancer chemopreventive dithiolethiones. Carcinogenesis. 30: 480-6. PMID 19126641 DOI: 10.1093/carcin/bgn292  1
2009 Sussan TE, Rangasamy T, Blake DJ, Malhotra D, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, Sporn MB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, et al. Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 250-5. PMID 19104057 DOI: 10.1073/pnas.0804333106  1
2009 Singh A, Ling G, Suhasini AN, Zhang P, Yamamoto M, Navas-Acien A, Cosgrove G, Tuder RM, Kensler TW, Watson WH, Biswal S. Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs. Free Radical Biology & Medicine. 46: 376-86. PMID 19027064 DOI: 10.1016/j.freeradbiomed.2008.10.026  1
2008 Colburn NH, Kensler TW. Targeting transcription factors for cancer prevention--the case of Nrf2. Cancer Prevention Research (Philadelphia, Pa.). 1: 153-5. PMID 19138949 DOI: 10.1158/1940-6207.CAPR-08-0025  1
2008 Williams MA, Rangasamy T, Bauer SM, Killedar S, Karp M, Kensler TW, Yamamoto M, Breysse P, Biswal S, Georas SN. Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter. Journal of Immunology (Baltimore, Md. : 1950). 181: 4545-59. PMID 18802057  1
2008 Egner PA, Kensler TW, Chen JG, Gange SJ, Groopman JD, Friesen MD. Quantification of sulforaphane mercapturic acid pathway conjugates in human urine by high-performance liquid chromatography and isotope-dilution tandem mass spectrometry. Chemical Research in Toxicology. 21: 1991-6. PMID 18729326 DOI: 10.1021/tx800210k  1
2008 Liby K, Yore MM, Roebuck BD, Baumgartner KJ, Honda T, Sundararajan C, Yoshizawa H, Gribble GW, Williams CR, Risingsong R, Royce DB, Dinkova-Kostova AT, Stephenson KK, Egner PA, Yates MS, ... ... Kensler TW, et al. A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin Cancer Research. 68: 6727-6733. PMID 18701497 DOI: 10.1158/0008-5472.CAN-08-1123  1
2008 Bransfield LA, Rennie A, Visvanathan K, Odwin SA, Kensler TW, Yager JD, Friesen MD, Groopman JD. Formation of two novel estrogen guanine adducts and HPLC/MS detection of 4-hydroxyestradiol-N7-guanine in human urine. Chemical Research in Toxicology. 21: 1622-30. PMID 18582124 DOI: 10.1021/tx800145w  1
2008 Reddy NM, Kleeberger SR, Bream JH, Fallon PG, Kensler TW, Yamamoto M, Reddy SP. Genetic disruption of the Nrf2 compromises cell-cycle progression by impairing GSH-induced redox signaling. Oncogene. 27: 5821-32. PMID 18542053 DOI: 10.1038/onc.2008.188  1
2008 Osburn WO, Yates MS, Dolan PD, Chen S, Liby KT, Sporn MB, Taguchi K, Yamamoto M, Kensler TW. Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 104: 218-27. PMID 18417483 DOI: 10.1093/toxsci/kfn079  1
2008 Bodreddigari S, Jones LK, Egner PA, Groopman JD, Sutter CH, Roebuck BD, Guengerich FP, Kensler TW, Sutter TR. Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3. Chemical Research in Toxicology. 21: 1134-42. PMID 18416522 DOI: 10.1021/tx7004458  1
2008 Pearson KJ, Lewis KN, Price NL, Chang JW, Perez E, Cascajo MV, Tamashiro KL, Poosala S, Csiszar A, Ungvari Z, Kensler TW, Yamamoto M, Egan JM, Longo DL, Ingram DK, et al. Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proceedings of the National Academy of Sciences of the United States of America. 105: 2325-30. PMID 18287083 DOI: 10.1073/pnas.0712162105  1
2008 Johnson DN, Egner PA, Obrian G, Glassbrook N, Roebuck BD, Sutter TR, Payne GA, Kensler TW, Groopman JD. Quantification of urinary aflatoxin B1 dialdehyde metabolites formed by aflatoxin aldehyde reductase using isotope dilution tandem mass spectrometry. Chemical Research in Toxicology. 21: 752-60. PMID 18266327 DOI: 10.1021/tx700397n  1
2008 Osburn WO, Kensler TW. Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. Mutation Research. 659: 31-9. PMID 18164232 DOI: 10.1016/j.mrrev.2007.11.006  0.88
2008 Groopman JD, Kensler TW, Wild CP. Protective interventions to prevent aflatoxin-induced carcinogenesis in developing countries. Annual Review of Public Health. 29: 187-203. PMID 17914931 DOI: 10.1146/annurev.publhealth.29.020907.090859  1
2008 Groopman JD, Kensler TW, Wild C. Aflatoxin, Hepatitis B Virus and Liver Cancer: A Paradigm for Molecular Epidemiology Molecular Epidemiology of Chronic Diseases. 323-342. DOI: 10.1002/9780470725726.ch25  1
2007 Petersen KS, Dolan PM, Kensler TW, Peleg S, Posner GH. Low-calcemic, highly antiproliferative, 23-oxa ether analogs of the natural hormone 1α,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation Journal of Medicinal Chemistry. 50: 5824-5832. PMID 17924616 DOI: 10.1021/jm070882d  1
2007 Papaiahgari S, Yerrapureddy A, Reddy SR, Reddy NM, Dodd-O JM, Crow MT, Grigoryev DN, Barnes K, Tuder RM, Yamamoto M, Kensler TW, Biswal S, Mitzner W, Hassoun PM, Reddy SP. Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice. American Journal of Respiratory and Critical Care Medicine. 176: 1222-35. PMID 17901416 DOI: 10.1164/rccm.200701-060OC  1
2007 Reddy NM, Kleeberger SR, Yamamoto M, Kensler TW, Scollick C, Biswal S, Reddy SP. Genetic dissection of the Nrf2-dependent redox signaling-regulated transcriptional programs of cell proliferation and cytoprotection. Physiological Genomics. 32: 74-81. PMID 17895394 DOI: 10.1152/physiolgenomics.00126.2007  1
2007 Manandhar S, Cho JM, Kim JA, Kensler TW, Kwak MK. Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes. European Journal of Pharmacology. 577: 17-27. PMID 17854798 DOI: 10.1016/j.ejphar.2007.08.018  1
2007 Thimmulappa RK, Fuchs RJ, Malhotra D, Scollick C, Traore K, Bream JH, Trush MA, Liby KT, Sporn MB, Kensler TW, Biswal S. Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils. Antioxidants & Redox Signaling. 9: 1963-70. PMID 17822364 DOI: 10.1089/ars.2007.1745  1
2007 Yates MS, Kensler TW. Keap1 eye on the target: chemoprevention of liver cancer. Acta Pharmacologica Sinica. 28: 1331-42. PMID 17723167 DOI: 10.1111/j.1745-7254.2007.00688.x  0.96
2007 Shin S, Wakabayashi N, Misra V, Biswal S, Lee GH, Agoston ES, Yamamoto M, Kensler TW. NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis. Molecular and Cellular Biology. 27: 7188-97. PMID 17709388 DOI: 10.1128/MCB.00915-07  0.72
2007 Kwak MK, Cho JM, Huang B, Shin S, Kensler TW. Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells. Free Radical Biology & Medicine. 43: 809-17. PMID 17664144 DOI: 10.1016/j.freeradbiomed.2007.05.029  0.72
2007 Osburn WO, Karim B, Dolan PM, Liu G, Yamamoto M, Huso DL, Kensler TW. Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment. International Journal of Cancer. 121: 1883-91. PMID 17631644 DOI: 10.1002/ijc.22943  0.88
2007 Wang J, Fields J, Zhao C, Langer J, Thimmulappa RK, Kensler TW, Yamamoto M, Biswal S, Doré S. Role of Nrf2 in protection against intracerebral hemorrhage injury in mice. Free Radical Biology & Medicine. 43: 408-14. PMID 17602956 DOI: 10.1016/j.freeradbiomed.2007.04.020  1
2007 Usera AR, Dolan PM, Kensler TW, Posner GH. Antiproliferative, low-calcemic, fluorinated sulfone analogs of 1α,25-dihydroxyvitamin D3: Chemical synthesis and biological evaluation Bioorganic and Medicinal Chemistry. 15: 5509-5518. PMID 17560112 DOI: 10.1016/j.bmc.2007.05.051  1
2007 Chen JG, Kuang SY, Egner PA, Lu JH, Zhu YR, Wang JB, Zhang BC, Chen TY, Muñoz A, Kensler TW, Groopman JD. Acceleration to death from liver cancer in people with hepatitis B viral mutations detected in plasma by mass spectrometry. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 16: 1213-8. PMID 17548687 DOI: 10.1158/1055-9965.EPI-06-0905  1
2007 Kwak MK, Huang B, Chang H, Kim JA, Kensler TW. Tissue specific increase of the catalytic subunits of the 26S proteasome by indirect antioxidant dithiolethione in mice: enhanced activity for degradation of abnormal protein. Life Sciences. 80: 2411-20. PMID 17521679 DOI: 10.1016/j.lfs.2007.04.014  0.44
2007 Shah ZA, Li RC, Thimmulappa RK, Kensler TW, Yamamoto M, Biswal S, Doré S. Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury. Neuroscience. 147: 53-9. PMID 17507167 DOI: 10.1016/j.neuroscience.2007.02.066  1
2007 Yates MS, Kensler TW. Chemopreventive promise of targeting the Nrf2 pathway. Drug News & Perspectives. 20: 109-17. PMID 17440634 DOI: 10.1358/dnp.2007.20.2.108343  0.96
2007 Reddy NM, Kleeberger SR, Cho HY, Yamamoto M, Kensler TW, Biswal S, Reddy SP. Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants. American Journal of Respiratory Cell and Molecular Biology. 37: 3-8. PMID 17413030 DOI: 10.1165/rcmb.2007-0004RC  1
2007 Fahey JW, Kensler TW. Role of dietary supplements/nutraceuticals in chemoprevention through induction of cytoprotective enzymes. Chemical Research in Toxicology. 20: 572-6. PMID 17362031 DOI: 10.1021/tx7000459  0.32
2007 Cornblatt BS, Ye L, Dinkova-Kostova AT, Erb M, Fahey JW, Singh NK, Chen MSA, Stierer T, Garrett-Mayer E, Argani P, Davidson NE, Talalay P, Kensler TW, Visvanathan K. Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast Carcinogenesis. 28: 1485-1490. PMID 17347138 DOI: 10.1093/carcin/bgm049  1
2007 Simonich MT, Egner PA, Roebuck BD, Orner GA, Jubert C, Pereira C, Groopman JD, Kensler TW, Dashwood RH, Williams DE, Bailey GS. Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat. Carcinogenesis. 28: 1294-302. PMID 17290047 DOI: 10.1093/carcin/bgm027  1
2007 Gong J, Vaidyanathan VG, Yu X, Kensler TW, Peterson LA, Sturla SJ. Depurinating acylfulvene-DNA adducts: characterizing cellular chemical reactions of a selective antitumor agent. Journal of the American Chemical Society. 129: 2101-11. PMID 17256933 DOI: 10.1021/ja0665951  1
2007 Yates MS, Tauchi M, Katsuoka F, Flanders KC, Liby KT, Honda T, Gribble GW, Johnson DA, Johnson JA, Burton NC, Guilarte TR, Yamamoto M, Sporn MB, Kensler TW. Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. Molecular Cancer Therapeutics. 6: 154-62. PMID 17237276 DOI: 10.1158/1535-7163.MCT-06-0516  1
2007 Posner GH, Suh BC, Petersen KS, Dolan P, Agoston ES, Kensler TW, Koh JT, Peleg S. Difluoromethyl analogs of the natural hormone 1α,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation Journal of Steroid Biochemistry and Molecular Biology. 103: 213-221. PMID 17218093 DOI: 10.1016/j.jsbmb.2006.12.024  1
2007 Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annual Review of Pharmacology and Toxicology. 47: 89-116. PMID 16968214 DOI: 10.1146/annurev.pharmtox.46.120604.141046  0.72
2006 Peleg S, Petersen KS, Suh BC, Dolan P, Agoston ES, Kensler TW, Posner GH. Low-calcemic, highly antiproliferative, 1-difluoromethyl hybrid analogs of the natural hormone 1α,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation Journal of Medicinal Chemistry. 49: 7513-7517. PMID 17149880 DOI: 10.1021/jm0609925  1
2006 Thimmulappa RK, Scollick C, Traore K, Yates M, Trush MA, Liby KT, Sporn MB, Yamamoto M, Kensler TW, Biswal S. Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. Biochemical and Biophysical Research Communications. 351: 883-9. PMID 17097057 DOI: 10.1016/j.bbrc.2006.10.102  1
2006 Egner PA, Groopman JD, Wang JS, Kensler TW, Friesen MD. Quantification of aflatoxin-B1-N7-Guanine in human urine by high-performance liquid chromatography and isotope dilution tandem mass spectrometry. Chemical Research in Toxicology. 19: 1191-5. PMID 16978023 DOI: 10.1021/tx060108d  1
2006 Osburn WO, Wakabayashi N, Misra V, Nilles T, Biswal S, Trush MA, Kensler TW. Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion. Archives of Biochemistry and Biophysics. 454: 7-15. PMID 16962985 DOI: 10.1016/j.abb.2006.08.005  0.88
2006 Burton NC, Kensler TW, Guilarte TR. In vivo modulation of the Parkinsonian phenotype by Nrf2. Neurotoxicology. 27: 1094-100. PMID 16959318 DOI: 10.1016/j.neuro.2006.07.019  1
2006 Skipper PL, Trudel LJ, Kensler TW, Groopman JD, Egner PA, Liberman RG, Wogan GN, Tannenbaum SR. DNA adduct formation by 2,6-dimethyl-, 3,5-dimethyl-, and 3-ethylaniline in vivo in mice. Chemical Research in Toxicology. 19: 1086-90. PMID 16918249 DOI: 10.1021/tx060082q  1
2006 Yu X, Egner PA, Wakabayashi J, Wakabayashi N, Yamamoto M, Kensler TW. Nrf2-mediated induction of cytoprotective enzymes by 15-deoxy-Delta12,14-prostaglandin J2 is attenuated by alkenal/one oxidoreductase. The Journal of Biological Chemistry. 281: 26245-52. PMID 16857669 DOI: 10.1074/jbc.M604620200  1
2006 Singh A, Rangasamy T, Thimmulappa RK, Lee H, Osburn WO, Brigelius-Flohé R, Kensler TW, Yamamoto M, Biswal S. Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2. American Journal of Respiratory Cell and Molecular Biology. 35: 639-50. PMID 16794261 DOI: 10.1165/rcmb.2005-0325OC  0.88
2006 Sinishtaj S, Jeon HB, Dolan P, Kensler TW, Posner GH. Highly antiproliferative, low-calcemic, side-chain amide and hydroxamate analogs of the hormone 1α,25-dihydroxyvitamin D3 Bioorganic and Medicinal Chemistry. 14: 6341-6348. PMID 16765598 DOI: 10.1016/j.bmc.2006.05.050  1
2006 Gong J, Neels JF, Yu X, Kensler TW, Peterson LA, Sturla SJ. Investigating the role of stereochemistry in the activity of anticancer acylfulvenes: synthesis, reductase-mediated bioactivation, and cellular toxicity. Journal of Medicinal Chemistry. 49: 2593-9. PMID 16610802 DOI: 10.1021/jm051104t  1
2006 Thimmulappa RK, Lee H, Rangasamy T, Reddy SP, Yamamoto M, Kensler TW, Biswal S. Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. The Journal of Clinical Investigation. 116: 984-95. PMID 16585964 DOI: 10.1172/JCI25790  1
2006 Yates MS, Kwak MK, Egner PA, Groopman JD, Bodreddigari S, Sutter TR, Baumgartner KJ, Roebuck BD, Liby KT, Yore MM, Honda T, Gribble GW, Sporn MB, Kensler TW. Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole. Cancer Research. 66: 2488-94. PMID 16489057 DOI: 10.1158/0008-5472.CAN-05-3823  1
2006 Agoston ES, Hatcher MA, Kensler TW, Posner GH. Vitamin D analogs as anti-carcinogenic agents Anti-Cancer Agents in Medicinal Chemistry. 6: 53-71. PMID 16475927 DOI: 10.2174/187152006784111369  1
2006 Scholl PF, McCoy L, Kensler TW, Groopman JD. Quantitative analysis and chronic dosimetry of the aflatoxin B1 plasma albumin adduct Lys-AFB1 in rats by isotope dilution mass spectrometry. Chemical Research in Toxicology. 19: 44-9. PMID 16411655 DOI: 10.1021/tx050251r  1
2006 Karuri AR, Huang Y, Bodreddigari S, Sutter CH, Roebuck BD, Kensler TW, Sutter TR. 3H-1,2-dithiole-3-thione targets nuclear factor kappaB to block expression of inducible nitric-oxide synthase, prevents hypotension, and improves survival in endotoxemic rats. The Journal of Pharmacology and Experimental Therapeutics. 317: 61-7. PMID 16371450 DOI: 10.1124/jpet.105.096396  1
2006 Huang Y, Yan J, Lubet R, Kensler TW, Sutter TR. Identification of novel transcriptional networks in response to treatment with the anticarcinogen 3H-1,2-dithiole-3-thione. Physiological Genomics. 24: 144-53. PMID 16317079 DOI: 10.1152/physiolgenomics.00258.2005  0.44
2006 Okawa H, Motohashi H, Kobayashi A, Aburatani H, Kensler TW, Yamamoto M. Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity. Biochemical and Biophysical Research Communications. 339: 79-88. PMID 16293230 DOI: 10.1016/j.bbrc.2005.10.185  0.4
2005 Groopman JD, Johnson D, Kensler TW. Aflatoxin and hepatitis B virus biomarkers: a paradigm for complex environmental exposures and cancer risk. Cancer Biomarkers : Section a of Disease Markers. 1: 5-14. PMID 17192028  1
2005 Cutler R, Guarante LP, Kensler TW, Naftolin F, Jones DP, Cantor CR, Martin GM. Longevity determinant genes: what is the evidence? What's the importance? Panel discussion. Annals of the New York Academy of Sciences. 1055: 58-63. PMID 16387718 DOI: 10.1196/annals.1323.010  1
2005 Kensler TW, Chen JG, Egner PA, Fahey JW, Jacobson LP, Stephenson KK, Ye L, Coady JL, Wang JB, Wu Y, Sun Y, Zhang QN, Zhang BC, Zhu YR, Qian GS, et al. Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People's Republic of China. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 14: 2605-13. PMID 16284385 DOI: 10.1158/1055-9965.EPI-05-0368  1
2005 Healy ZR, Lee NH, Gao X, Goldring MB, Talalay P, Kensler TW, Konstantopoulos K. Divergent responses of chondrocytes and endothelial cells to shear stress: Cross-talk among COX-2, the phase 2 response, and apoptosis Proceedings of the National Academy of Sciences of the United States of America. 102: 14010-14015. PMID 16172382 DOI: 10.1073/pnas.0506620102  1
2005 Posner GH, Hyung JK, Kahraman M, Heung BJ, Byung CS, Li H, Dolan P, Kensler TW. Highly antiproliferative, low-calcemic, side-chain ketone analogs of the hormone 1α,25-dihydroxyvitamin D3 Bioorganic and Medicinal Chemistry. 13: 5569-5580. PMID 16039132 DOI: 10.1016/j.bmc.2005.06.031  1
2005 Rangasamy T, Guo J, Mitzner WA, Roman J, Singh A, Fryer AD, Yamamoto M, Kensler TW, Tuder RM, Georas SN, Biswal S. Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. The Journal of Experimental Medicine. 202: 47-59. PMID 15998787 DOI: 10.1084/jem.20050538  1
2005 Groopman JD, Kensler TW. Role of metabolism and viruses in aflatoxin-induced liver cancer. Toxicology and Applied Pharmacology. 206: 131-7. PMID 15967201 DOI: 10.1016/j.taap.2004.09.020  1
2005 Hatcher MA, Peleg S, Dolan P, Kensler TW, Sarjeant A, Posner GH. A-ring hydroxymethyl 19-nor analogs of the natural hormone 1α,25-dihydroxyvitamin D3: Synthesis and preliminary biological evaluation Bioorganic and Medicinal Chemistry. 13: 3964-3976. PMID 15878279 DOI: 10.1016/j.bmc.2005.04.010  1
2005 Chu H, Kensler TW, Muñoz A. Assessing the effect of interventions in the context of mixture distributions with detection limits. Statistics in Medicine. 24: 2053-67. PMID 15803450 DOI: 10.1002/sim.2079  0.36
2005 Posner GH, Lee SHT, Kim HJ, Peleg S, Dolan P, Kensler TW. Novel A-ring analogs of the hormone 1α,25-dihydroxyvitamin D 3: Synthesis and preliminary biological evaluation Bioorganic and Medicinal Chemistry. 13: 2959-2966. PMID 15781405 DOI: 10.1016/j.bmc.2005.02.005  1
2005 Fahey JW, Stephenson KK, Dinkova-Kostova AT, Egner PA, Kensler TW, Talalay P. Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes Carcinogenesis. 26: 1247-1255. PMID 15774490 DOI: 10.1093/carcin/bgi068  1
2004 Kahraman M, Sinishtaj S, Dolan PM, Kensler TW, Peleg S, Saha U, Chuang SS, Bernstein G, Korczak B, Posner GH. Potent, selective and low-calcemic inhibitors of CYP24 Hydroxylase: 24-Sulfoximine analogues of the hormone 1α,25-dihydroxyvitamin D 3 Journal of Medicinal Chemistry. 47: 6854-6863. PMID 15615534 DOI: 10.1021/jm040129  1
2004 Posner GH, Jeon HB, Sarjeant A, Riccio ES, Doppalapudi RS, Kapetanovic IM, Saha U, Dolan P, Kensler TW. Low-calcemic, efficacious, 1α,25-dihydroxyvitamin D 3 analog QW-1624F 2-2: Calcemic dose-response determination, preclinical genotoxicity testing, and revision of A-ring stereochemistry Steroids. 69: 757-762. PMID 15579327 DOI: 10.1016/j.steroids.2004.09.004  1
2004 Rangasamy T, Cho CY, Thimmulappa RK, Zhen L, Srisuma SS, Kensler TW, Yamamoto M, Petrache I, Tuder RM, Biswal S. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. The Journal of Clinical Investigation. 114: 1248-59. PMID 15520857 DOI: 10.1172/JCI21146  1
2004 Kensler TW, Egner PA, Wang JB, Zhu YR, Zhang BC, Lu PX, Chen JG, Qian GS, Kuang SY, Jackson PE, Gange SJ, Jacobson LP, Muñoz A, Groopman JD. Chemoprevention of hepatocellular carcinoma in aflatoxin endemic areas. Gastroenterology. 127: S310-8. PMID 15508099 DOI: 10.1053/j.gastro.2004.09.046  1
2004 Anderson SP, Howroyd P, Liu J, Qian X, Bahnemann R, Swanson C, Kwak MK, Kensler TW, Corton JC. The transcriptional response to a peroxisome proliferator-activated receptor alpha agonist includes increased expression of proteome maintenance genes. The Journal of Biological Chemistry. 279: 52390-8. PMID 15375163 DOI: 10.1074/jbc.M409347200  0.44
2004 Corton JC, Apte U, Anderson SP, Limaye P, Yoon L, Latendresse J, Dunn C, Everitt JI, Voss KA, Swanson C, Kimbrough C, Wong JS, Gill SS, Chandraratna RA, Kwak MK, ... Kensler TW, et al. Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors. The Journal of Biological Chemistry. 279: 46204-12. PMID 15302862 DOI: 10.1074/jbc.M406739200  1
2004 Kwak MK, Ramos-Gomez M, Wakabayashi N, Kensler TW. Chemoprevention by 1,2-dithiole-3-thiones through induction of NQO1 and other phase 2 enzymes. Methods in Enzymology. 382: 414-23. PMID 15047114 DOI: 10.1016/S0076-6879(04)82022-6  1
2004 Kuang SY, Jackson PE, Wang JB, Lu PX, Muñoz A, Qian GS, Kensler TW, Groopman JD. Specific mutations of hepatitis B virus in plasma predict liver cancer development. Proceedings of the National Academy of Sciences of the United States of America. 101: 3575-80. PMID 14990795 DOI: 10.1073/pnas.0308232100  1
2004 Dick RA, Yu X, Kensler TW. NADPH alkenal/one oxidoreductase activity determines sensitivity of cancer cells to the chemotherapeutic alkylating agent irofulven. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 1492-9. PMID 14977853  1
2004 Dick RA, Kensler TW. The catalytic and kinetic mechanisms of NADPH-dependent alkenal/one oxidoreductase. The Journal of Biological Chemistry. 279: 17269-77. PMID 14966122 DOI: 10.1074/jbc.M400427200  1
2004 Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang MI, Kobayashi A, Yamamoto M, Kensler TW, Talalay P. Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers Proceedings of the National Academy of Sciences of the United States of America. 101: 2040-2045. PMID 14764894 DOI: 10.1073/pnas.0307301101  1
2003 Petzer JP, Navamal M, Johnson JK, Kwak MK, Kensler TW, Fishbein JC. Phase 2 enzyme induction by the major metabolite of oltipraz. Chemical Research in Toxicology. 16: 1463-9. PMID 14615973 DOI: 10.1021/tx034154e  1
2003 Roebuck BD, Curphey TJ, Li Y, Baumgartner KJ, Bodreddigari S, Yan J, Gange SJ, Kensler TW, Sutter TR. Evaluation of the cancer chemopreventive potency of dithiolethione analogs of oltipraz. Carcinogenesis. 24: 1919-28. PMID 14555609 DOI: 10.1093/carcin/bgg173  1
2003 Egner PA, Yu X, Johnson JK, Nathasingh CK, Groopman JD, Kensler TW, Roebuck BD. Identification of aflatoxin M1-N7-guanine in liver and urine of tree shrews and rats following administration of aflatoxin B1. Chemical Research in Toxicology. 16: 1174-80. PMID 12971806 DOI: 10.1021/tx034106u  1
2003 Guyton KZ, Kensler TW, Posner GH. Vitamin D and vitamin D analogs as cancer chemopreventive agents. Nutrition Reviews. 61: 227-38. PMID 12918875 DOI: 10.1301/nr.2003.jul.227-238  1
2003 Jackson PE, Kuang SY, Wang JB, Strickland PT, Muñoz A, Kensler TW, Qian GS, Groopman JD. Prospective detection of codon 249 mutations in plasma of hepatocellular carcinoma patients. Carcinogenesis. 24: 1657-63. PMID 12869416 DOI: 10.1093/carcin/bgg101  1
2003 Kwak MK, Kensler TW, Casero RA. Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein. Biochemical and Biophysical Research Communications. 305: 662-70. PMID 12763045 DOI: 10.1016/S0006-291X(03)00834-9  0.44
2003 Kensler TW, Qian GS, Chen JG, Groopman JD. Translational strategies for cancer prevention in liver. Nature Reviews. Cancer. 3: 321-9. PMID 12724730 DOI: 10.1038/nrc1076  1
2003 Ramos-Gomez M, Dolan PM, Itoh K, Yamamoto M, Kensler TW. Interactive effects of nrf2 genotype and oltipraz on benzo[a]pyrene-DNA adducts and tumor yield in mice. Carcinogenesis. 24: 461-7. PMID 12663505 DOI: 10.1093/carcin/24.3.461  1
2003 Egner PA, Muñoz A, Kensler TW. Chemoprevention with chlorophyllin in individuals exposed to dietary aflatoxin. Mutation Research. 523: 209-16. PMID 12628519 DOI: 10.1016/S0027-5107(02)00337-8  1
2002 Dick RA, Kensler TW. Chemoprotective potential of phase 2 enzyme inducers. Expert Review of Anticancer Therapy. 2: 581-92. PMID 12382526 DOI: 10.1586/14737140.2.5.581  1
2002 Fahey JW, Haristoy X, Dolan PM, Kensler TW, Scholtus I, Stephenson KK, Talalay P, Lozniewski A. Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors Proceedings of the National Academy of Sciences of the United States of America. 99: 7610-7615. PMID 12032331 DOI: 10.1073/pnas.112203099  1
2002 Posner GH, Woodard BT, Crawford KR, Peleg S, Brown AJ, Dolan P, Kensler TW. 2,2-Disubstituted analogues of the natural hormone 1 alpha,25-dihydroxyvitamin D(3): chemistry and biology. Bioorganic & Medicinal Chemistry. 10: 2353-65. PMID 11983533 DOI: 10.1016/S0968-0896(02)00058-5  1
2002 Posner GH, Halford BA, Peleg S, Dolan P, Kensler TW. Conceptually new low-calcemic oxime analogues of the hormone 1 alpha,25-dihydroxyvitamin D(3): synthesis and biological testing. Journal of Medicinal Chemistry. 45: 1723-30. PMID 11931627 DOI: 10.1021/jm010560o  1
2002 Cho HY, Jedlicka AE, Reddy SP, Kensler TW, Yamamoto M, Zhang LY, Kleeberger SR. Role of NRF2 in protection against hyperoxic lung injury in mice. American Journal of Respiratory Cell and Molecular Biology. 26: 175-82. PMID 11804867 DOI: 10.1165/ajrcmb.26.2.4501  0.4
2002 Cho HY, Jedlicka AE, Reddy SP, Zhang LY, Kensler TW, Kleeberger SR. Linkage analysis of susceptibility to hyperoxia. Nrf2 is a candidate gene. American Journal of Respiratory Cell and Molecular Biology. 26: 42-51. PMID 11751202 DOI: 10.1165/ajrcmb.26.1.4536  0.32
2002 Posner GH, Northrop J, Paik IH, Borstnik K, Dolan P, Kensler TW, Xie S, Shapiro TA. New chemical and biological aspects of artemisinin-derived trioxane dimers. Bioorganic & Medicinal Chemistry. 10: 227-32. PMID 11738625 DOI: 10.1016/S0968-0896(01)00270-X  1
2001 Nelson WG, De Marzo AM, Deweese TL, Lin X, Brooks JD, Putzi MJ, Nelson CP, Groopman JD, Kensler TW. Preneoplastic prostate lesions: an opportunity for prostate cancer prevention. Annals of the New York Academy of Sciences. 952: 135-44. PMID 11795433  1
2001 Egner PA, Wang JB, Zhu YR, Zhang BC, Wu Y, Zhang QN, Qian GS, Kuang SY, Gange SJ, Jacobson LP, Helzlsouer KJ, Bailey GS, Groopman JD, Kensler TW. Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer Proceedings of the National Academy of Sciences of the United States of America. 98: 14601-14606. PMID 11724948 DOI: 10.1073/pnas.251536898  1
2001 Posner GH, Crawford KR, Peleg S, Welsh JE, Romu S, Gewirtz DA, Gupta MS, Dolan P, Kensler TW. A non-calcemic sulfone version of the vitamin D(3) analogue seocalcitol (EB 1089): chemical synthesis, biological evaluation and potency enhancement of the anticancer drug adriamycin. Bioorganic & Medicinal Chemistry. 9: 2365-71. PMID 11553477 DOI: 10.1016/S0968-0896(01)00159-6  1
2001 Parsons JK, Nelson CP, Gage WR, Nelson WG, Kensler TW, De Marzo AM. GSTA1 expression in normal, preneoplastic, and neoplastic human prostate tissue. The Prostate. 49: 30-7. PMID 11550208 DOI: 10.1002/pros.1115  0.4
2001 Dick RA, Kwak MK, Sutter TR, Kensler TW. Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase. The Journal of Biological Chemistry. 276: 40803-10. PMID 11524419 DOI: 10.1074/jbc.M105487200  1
2001 Carey KA, Kensler TW, Fishbein JC. Kinetic constraints for the thiolysis of 4-methyl-5-(pyrazin-2-yl)-1,2-dithiole-3-thione (oltipraz) and related dithiole-3-thiones in aqueous solution Chemical Research in Toxicology. 14: 939-945. PMID 11511166 DOI: 10.1021/tx0100340  1
2001 Kwak MK, Egner PA, Dolan PM, Ramos-Gomez M, Groopman JD, Itoh K, Yamamoto M, Kensler TW. Role of phase 2 enzyme induction in chemoprotection by dithiolethiones. Mutation Research. 480: 305-15. PMID 11506823  1
2001 Walton M, Egner P, Scholl PF, Walker J, Kensler TW, Groopman JD. Liquid chromatography electrospray-mass spectrometry of urinary aflatoxin biomarkers: Characterization and application to dosimetry and chemoprevention in rats Chemical Research in Toxicology. 14: 919-926. PMID 11453740 DOI: 10.1021/tx010063a  1
2001 Guyton KZ, Kensler TW, Posner GH. Cancer chemoprevention using natural vitamin D and synthetic analogs. Annual Review of Pharmacology and Toxicology. 41: 421-42. PMID 11264464 DOI: 10.1146/annurev.pharmtox.41.1.421  1
2001 Ramos-Gomez M, Kwak MK, Dolan PM, Itoh K, Yamamoto M, Talalay P, Kensler TW. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice Proceedings of the National Academy of Sciences of the United States of America. 98: 3410-3415. PMID 11248092 DOI: 10.1073/pnas.051618798  1
2001 Nelson CP, Kidd LC, Sauvageot J, Isaacs WB, De Marzo AM, Groopman JD, Nelson WG, Kensler TW. Protection against 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine cytotoxicity and DNA adduct formation in human prostate by glutathione S-transferase P1. Cancer Research. 61: 103-9. PMID 11196146  1
2000 Posner GH, Crawford K, Siu-Caldera ML, Reddy GS, Sarabia SF, Feldman D, van Etten E, Mathieu C, Gennaro L, Vouros P, Peleg S, Dolan PM, Kensler TW. Conceptually new 20-epi-22-oxa sulfone analogues of the hormone 1alpha,25-dihydroxyvitamin D(3): synthesis and biological evaluation. Journal of Medicinal Chemistry. 43: 3581-6. PMID 11000014 DOI: 10.1021/jm000215j  1
2000 Egner PA, Stansbury KH, Snyder EP, Rogers ME, Hintz PA, Kensler TW. Identification and characterization of chlorin e4 ethyl ester in sera of individuals participating in the chlorophyllin chemoprevention trial Chemical Research in Toxicology. 13: 900-906. PMID 10995263 DOI: 10.1021/tx000069k  1
2000 Kensler TW, Dolan PM, Gange SJ, Lee JK, Wang Q, Posner GH. Conceptually new deltanoids (vitamin D analogs) inhibit multistage skin tumorigenesis. Carcinogenesis. 21: 1341-5. PMID 10874012  1
2000 Li Y, Su JJ, Qin LL, Egner PA, Wang JS, Groopman JD, Kensler TW, Roebuck BD. Reduction of aflatoxin B1 adduct biomarkers by oltipraz in the tree shrew (Tupaia belangeri chinensis) Cancer Letters. 154: 79-83. PMID 10799742 DOI: 10.1016/S0304-3835(00)00382-7  1
1999 Kensler TW, Tsuda H, Wogan GN. United States-Japan workshop on New Rodent Models for the Analysis and Prevention of Carcinogenesis. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 8: 1033-7. PMID 10566560  1
1999 Wang SS, O'Neill JP, Qian GS, Zhu YR, Wang JB, Armenian H, Zarba A, Wang JS, Kensler TW, Cariello NF, Groopman JD, Swenberg JA. Elevated HPRT mutation frequencies in aflatoxin-exposed residents of daxin, Qidong county, People's Republic of China. Carcinogenesis. 20: 2181-4. PMID 10545423 DOI: 10.1093/carcin/20.11.2181  1
1999 Posner GH, Ploypradith P, Parker MH, O'Dowd H, Woo SH, Northrop J, Krasavin M, Dolan P, Kensler TW, Xie S, Shapiro TA. Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers. Journal of Medicinal Chemistry. 42: 4275-80. PMID 10543871 DOI: 10.1021/jm990363d  1
1999 Posner GH, Wang Q, Han G, Lee JK, Crawford K, Zand S, Brem H, Peleg S, Dolan P, Kensler TW. Conceptually new sulfone analogues of the hormone 1alpha, 25-dihydroxyvitamin D(3): synthesis and preliminary biological evaluation. Journal of Medicinal Chemistry. 42: 3425-35. PMID 10479276 DOI: 10.1021/jm990267c  1
1999 Knight LP, Primiano T, Groopman JD, Kensler TW, Sutter TR. cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3 Carcinogenesis. 20: 1215-1223. PMID 10383892 DOI: 10.1093/carcin/20.7.1215  1
1999 Links JM, Kensler TW, Groopman JD. Biomarkers in environmental health research & practice. Drug and Chemical Toxicology. 22: 1-14. PMID 10189567 DOI: 10.3109/01480549909029720  1
1999 Wang JS, Shen X, He X, Zhu YR, Zhang BC, Wang JB, Qian GS, Kuang SY, Zarba A, Egner PA, Jacobson LP, Muñoz A, Helzlsouer KJ, Groopman JD, Kensler TW. Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 oltipraz in residents of Qidong, People's Republic of China Journal of the National Cancer Institute. 91: 347-354. PMID 10050868  1
1999 Kensler TW, Groopman JD, Sutter TR, Curphey TJ, Roebuck BD. Development of cancer chemopreventive agents: Oltipraz as a paradigm Chemical Research in Toxicology. 12: 113-126. PMID 10027787 DOI: 10.1021/tx980185b  1
1999 Groopman JD, Kensler TW. The light at the end of the tunnel for chemical-specific biomarkers: Daylight or headlight? Carcinogenesis. 20: 1-11. PMID 9934843 DOI: 10.1093/carcin/20.1.1  1
1998 Maxuitenko YY, Libby AH, Joyner HH, Curphey TJ, MacMillan DL, Kensler TW, Roebuck BD. Identification of dithiolethiones with better chemopreventive properties than oltipraz. Carcinogenesis. 19: 1609-15. PMID 9771932 DOI: 10.1093/carcin/19.9.1609  1
1998 Posner GH, Lee JK, Wang Q, Peleg S, Burke M, Brem H, Dolan P, Kensler TW. Noncalcemic, antiproliferative, transcriptionally active, 24-fluorinated hybrid analogues of the hormone 1alpha, 25-dihydroxyvitamin D3. Synthesis and preliminary biological evaluation. Journal of Medicinal Chemistry. 41: 3008-14. PMID 9685240 DOI: 10.1021/jm980031t  1
1998 Kensler TW, Groopman JD, Roebuck BD. Use of aflatoxin adducts as intermediate endpoints to assess the efficacy of chemopreventive interventions in animals and man Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 402: 165-172. PMID 9675269 DOI: 10.1016/S0027-5107(97)00294-7  1
1997 Posner GH, Ploypradith P, Hapangama W, Wang D, Cumming JN, Dolan P, Kensler TW, Klinedinst D, Shapiro TA, Zheng QY, Murray CK, Pilkington LG, Jayasinghe LR, Bray JF, Daughenbaugh R. Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro. Bioorganic & Medicinal Chemistry. 5: 1257-65. PMID 9377085 DOI: 10.1016/S0968-0896(97)00079-5  1
1997 Posner GH, Lee JK, White MC, Hutchings RH, Dai H, Kachinski JL, Dolan P, Kensler TW. Antiproliferative Hybrid Analogs of the Hormone 1α,25-Dihydroxyvitamin D3: Design, Synthesis, and Preliminary Biological Evaluation Journal of Organic Chemistry. 62: 3291-3298. DOI: 10.1021/jo970049w  1
1997 Posner GH, Lee JK, White MC, Hutchings RH, Dai H, Kachinski JL, Dolan P, Kensler TW. Antiproliferative Hybrid Analogs of the Hormone 1α,25-Dihydroxyvitamin D3: Design, Synthesis, and Preliminary Biological Evaluation Journal of Organic Chemistry. 62: 3291-3298.  1
1996 Kensler TW, Groopman JD. Carcinogen-DNA and protein adducts: Biomarkers for cohort selection and modifiable endpoints in chemoprevention trials Journal of Cellular Biochemistry. 63: 85-91. PMID 9027603 DOI: 10.1002/(SICI)1097-4644(1996)25+<85::AID-JCB12>3.0.CO;2-M  1
1996 Primiano T, Kensler TW, Kuppusamy P, Zweier JL, Sutter TR. Induction of hepatic heme oxygenase-1 and ferritin in rats by cancer chemopreventive dithiolethiones Carcinogenesis. 17: 2291-2296. PMID 8968040 DOI: 10.1093/carcin/17.11.2291  1
1996 Kensler TW, Groopman JD, Wogan GN. Use of carcinogen-DNA and carcinogen-protein adduct biomarkers for cohort selection and as modifiable end points in chemoprevention trials. Iarc Scientific Publications. 237-48. PMID 8923034  1
1996 Scholl P, Musser SM, Kensler TW, Groopman JD. Inhibition of aflatoxin Ml excretion in rat urine during dietary intervention with oltipraz. Carcinogenesis. 17: 1385-8. PMID 8681461 DOI: 10.1093/carcin/17.6.1385  1
1995 Groopman JD, Kensler TW, Links JM. Molecular epidemiology and human risk monitoring Toxicology Letters. 82: 763-769. PMID 8597140 DOI: 10.1016/0378-4274(95)03594-X  1
1995 Kensler TW, Helzlsouer KJ. Oltipraz: clinical opportunities for cancer chemoprevention. p Journal of Cellular Biochemistry. Supplement. 22: 101-107. PMID 8538185 DOI: 10.1002/jcb.240590813  1
1995 Links JM, Kensler TW, Groopman JD. Biomarkers and mechanistic approaches in environmental epidemiology Annual Review of Public Health. 16: 83-103. PMID 7639885  1
1995 Egner PA, Gange SJ, Dolan PM, Groopman JD, Muñoz A, Kensler TW. Levels of aflatoxin-albumin biomarkers in rat plasma are modulated by both long-term and transient interventions with oltipraz Carcinogenesis. 16: 1769-1773. PMID 7634402 DOI: 10.1093/carcin/16.8.1769  1
1995 Scholl P, Musser SM, Kensler TW, Groopman JD. Molecular biomarkers for aflatoxins and their application to human liver cancer. Pharmacogenetics. 5: S171-6. PMID 7581490  1
1995 Posner GH, Li Z, White MC, Vinader V, Takeuchi K, Guggino SE, Dolan P, Kensler TW. 1 alpha,25-dihydroxyvitamin D3 analogs featuring aromatic and heteroaromatic rings: design, synthesis, and preliminary biological testing. Journal of Medicinal Chemistry. 38: 4529-37. PMID 7473581 DOI: 10.1021/jm00022a019  1
1995 Posner GH, Lee JK, Li Z, Takeuchi K, Guggino SE, Dolan P, Kensler TW. 1α,25-Dihydroxyvitamin D3 Hybrid Analogs with Structural changes at both the A-ring and the C,D-ring side-chain. II Bioorganic and Medicinal Chemistry Letters. 5: 2163-2168. DOI: 10.1016/0960-894X(95)00376-5  1
1994 Egner PA, Kensler TW, Prestera T, Talalay P, Libby AH, Joyner HH, Curphey TJ. Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones. Carcinogenesis. 15: 177-81. PMID 8313505  1
1994 Zhang Y, Kensler TW, Cho CG, Posner GH, Talalay P. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates. Proceedings of the National Academy of Sciences of the United States of America. 91: 3147-50. PMID 8159717  1
1994 Groopman JD, Wogan GN, Roebuck BD, Kensler TW. Molecular biomarkers for aflatoxins and their application to human cancer prevention. Cancer Research. 54: 1907s-1911s. PMID 8137310  1
1994 Groopman JD, Roebuck BD, Kensler TW. Carcinogen-DNA and protein adducts as intermediate biomarkers for human chemoprotection trials Advances in Experimental Medicine and Biology. 354: 149-160. PMID 8067283  1
1993 Meyer DJ, Harris JM, Gilmore KS, Coles B, Kensler TW, Ketterer B. Quantitation of tissue- and sex-specific induction of rat GSH transferase subunits by dietary 1,2-dithiole-3-thiones Carcinogenesis. 14: 567-572. PMID 8472316 DOI: 10.1093/carcin/14.4.567  1
1993 Akman SA, Kensler TW, Doroshow JH, Dizdaroglu M. Copper ion-mediated modification of bases in dna in vitro by benzoyl peroxide Carcinogenesis. 14: 1971-1974. PMID 8403227 DOI: 10.1093/carcin/14.9.1971  1
1993 Groopman JD, Wild CP, Hasler J, Junshi C, Wogan GN, Kensler TW. Molecular epidemiology of aflatoxin exposures: validation of aflatoxin-N7-guanine levels in urine as a biomarker in experimental rat models and humans. Environmental Health Perspectives. 99: 107-13. PMID 8319607  1
1993 Westra WH, Slebos RJC, Offerhaus GJA, Goodman SN, Evers SG, Kensler TW, Askin FB, Rodenhuis S, Hruban RH. K-ras oncogene activation in lung adenocarcinomas from former smokers: Evidence that K-ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung Cancer. 72: 432-438. PMID 8319174 DOI: 10.1002/1097-0142(19930715)72:2<432::AID-CNCR2820720219>3.0.CO;2  1
1993 Kensler TW, Davidson NE, Groopman JD, Roebuck BD, Prochaska HJ, Talalay P. Chemoprotection by inducers of electrophile detoxication enzymes. Basic Life Sciences. 61: 127-36. PMID 8304925  1
1993 Maxuitenko YY, MacMillan DL, Kensler TW, Roebuck BD. Evaluation of the post-initiation effects of oltipraz on aflatoxin B1-induced preneoplastic foci in a rat model of hepatic tumorigenesis. Carcinogenesis. 14: 2423-5. PMID 8242875 DOI: 10.1093/carcin/14.11.2423  1
1993 Helzlsouer KJ, Kensler TW. Cancer Chemoprotection by Oltipraz: Experimental and Clinical Considerations Preventive Medicine. 22: 783-795. PMID 8234218 DOI: 10.1006/pmed.1993.1072  1
1993 Styczynski PB, Blackmon RC, Groopman JD, Kensler TW. The direct glucuronidation of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) by human and rabbit liver microsomes. Chemical Research in Toxicology. 6: 846-51. PMID 8117924 DOI: 10.1021/tx00036a014  1
1993 Groopman JD, Kensler TW. Molecular biomarkers for human chemical carcinogen exposures Chemical Research in Toxicology. 6: 764-770. PMID 8117914 DOI: 10.1021/tx00036a004  1
1993 Posner GH, Guyton KZ, Kensler TW, Barsony J, Lieberman ME, Reddy GS, Clark JW, Wankadiya KF, Tserng KT. 1-(hydroxyalkyl)-25-hydroxyvitamin D3 analogs of calcitriol. 2. Preliminary biological evaluation Bioorganic and Medicinal Chemistry Letters. 3: 1835-1840. DOI: 10.1016/S0960-894X(00)80115-8  1
1993 Posner GH, Dai H, Afarinkia K, Murthy NN, Guyton KZ, Kensler TW. Asymmetric total synthesis, X-ray crystallography, and preliminary biological evaluation of 1-(1′-hydroxyethyl)-25-hydroxyvitamin D3 analogs of natural calcitriol Journal of Organic Chemistry. 58: 7209-7215.  1
1992 Groopman JD, Dematos P, Egner PA, Love-hunt A, Kensler TW. Molecular dosimetry of urinary aflatoxin-N-guanine and serum aflatoxin-albumin adducts predicts chemoprotection by l,2-dithiole-3-thione in rats Carcinogenesis. 13: 101-106. PMID 1733561 DOI: 10.1093/carcin/13.1.101  1
1992 Akman SA, Doroshow JH, Kensler TW. Copper-dependent site-specific mutagenesis by benzoyl peroxide in the supf gene of the mutation reporter plasmid ps189 Carcinogenesis. 13: 1783-1787. PMID 1423838 DOI: 10.1093/carcin/13.10.1783  1
1992 Kensler TW, Groopman JD, Eaton DL, Curphey TJ, Roebuck BD. Potent inhibition of aflatoxin-induced hepatic tumorigenesis by the monofunctional enzyme inducer l,2-dithiole-3-thione Carcinogenesis. 13: 95-100. PMID 1346373 DOI: 10.1093/carcin/13.1.95  1
1992 Posner GH, Nelson TD, Guyton KZ, Kensler TW. New vitamin D3 derivatives with unexpected antiproliferative activity: 1-(hydroxymethyl)-25-hydroxyvitamin D3 homologs. Journal of Medicinal Chemistry. 35: 3280-7. PMID 1324319  1
1991 Guyton KZ, Bhan P, Kuppusamy P, Zweier JL, Trush MA, Kensler TW. Free radical-derived quinone methide mediates skin tumor promotion by butylated hydroxytoluene hydroperoxide: Expanded role for electrophiles in multistage carcinogenesis Proceedings of the National Academy of Sciences of the United States of America. 88: 946-950. PMID 1846971  1
1991 Swauger JE, Dolan PM, Zweier JL, Kuppusamy P, Kensler TW. Role of the benzoyloxyl radical in DNA damage mediated by benzoyl peroxide Chemical Research in Toxicology. 4: 223-228. PMID 1782351  1
1988 Liu YL, Roebuck BD, Yager JD, Groopman JD, Kensler TW. Protection by 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) against the hepatotoxicity of aflatoxin B1 in the rat Toxicology and Applied Pharmacology. 93: 442-451. PMID 3130679 DOI: 10.1016/0041-008X(88)90047-6  1
1988 Groopman JD, Cain LG, Kensler TW, Harris CC. Aflatoxin exposure in human populations: Measurements and relationship to cancer Critical Reviews in Toxicology. 19: 113-145. PMID 3069332 DOI: 10.3109/10408448809014902  1
1987 Groopman JD, Kensler TW. The use of monoclonal antibody affinity columns for assessing DNA damage and repair following exposure to aflatoxin B1 Pharmacology and Therapeutics. 34: 321-334. PMID 3120202 DOI: 10.1016/0163-7258(87)90016-7  1
1987 Groopman JD, Roebuck BD, Kensler TW. Application of monoclonal antibodies and dietary antioxidant-based animal models to define human exposure to aflatoxin B1 Progress in Experimental Tumor Research. Fortschritte Der Experimentellen Tumorforschung. Progres De La Recherche Experimentale Des Tumeurs. 31: 52-62. PMID 2882562  1
1985 Egner PA, Kensler TW. Effects of a biomimetic superoxide dismutase on complete and multistage carcinogenesis in mouse skin. Carcinogenesis. 6: 1167-72. PMID 3926337 DOI: 10.1093/carcin/6.8.1167  0.36
1985 Kensler TW, Egner PA, Trush MA, Bueding E, Groopman JD. Modification of aflatoxin B1 binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquin and a dithiothione Carcinogenesis. 6: 759-763. PMID 3924431 DOI: 10.1093/carcin/6.5.759  1
1983 Sorenson JR, Oberley LW, Crouch RK, Kensler TW, Kishore V, Leuthauser SW, Oberley TD, Pezeshk A. Pharmacologic activities of copper compounds in chronic diseases. Biological Trace Element Research. 5: 257-73. PMID 24263565 DOI: 10.1007/BF02987212  1
1981 Kensler TW, Han N, Cooney DA. A straightforward method for the simultaneous preparation of radiolabeled l-dihydroörotic and N-carbamyl-l-aspartic acids Analytical Biochemistry. 111: 49-53. PMID 7235240 DOI: 10.1016/0003-2697(81)90226-8  1
1976 Kensler TW, Busby WF, Davidson NE, Wogan GN. Effect of hepatocarcinogens on the binding of glucocorticoid receptor complex in rat liver nuclei Cancer Research. 36: 4647-4651. PMID 1000507  1
1976 Kensler TW, Busby WF, Davidson NE, Wogan GN. Aflatoxin inhibition of glucocorticoid binding capacity of rat liver nuclei Bba - General Subjects. 437: 200-210. PMID 181075 DOI: 10.1016/0304-4165(76)90361-5  1
Show low-probability matches.