Thomas Wells Kensler - Publications

Affiliations: 
2010 Johns Hopkins University, Baltimore, MD 
 2010- Pharmacology & Chemical Biology University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Pharmacology, Biochemistry, Molecular Biology, Oncology
Website:
http://www.pharmacology.us/Faculty/ThomasKensler

154 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Yagishita Y, Fahey JW, Dinkova-Kostova AT, Kensler TW. Broccoli or Sulforaphane: Is It the Source or Dose That Matters? Molecules (Basel, Switzerland). 24. PMID 31590459 DOI: 10.3390/molecules24193593  0.32
2019 Livingstone MC, Johnson NM, Roebuck BD, Kensler TW, Groopman JD. Serum miR-182 is a predictive biomarker for dichotomization of risk of hepatocellular carcinoma in rats. Molecular Carcinogenesis. PMID 31373075 DOI: 10.1002/mc.23093  1
2019 Paunkov A, Chartoumpekis DV, Ziros PG, Chondrogianni N, Kensler TW, Sykiotis GP. Impact of Antioxidant Natural Compounds on the Thyroid Gland and Implication of the Keap1/Nrf2 Signaling Pathway. Current Pharmaceutical Design. PMID 31267862 DOI: 10.2174/1381612825666190701165821  0.4
2019 Chen J, Zhu J, Wang G, Groopman JD, Kensler TW. Qidong: a crucible for studies on liver cancer etiology and prevention. Cancer Biology & Medicine. 16: 24-37. PMID 31119044 DOI: 10.20892/j.issn.2095-3941.2018.0394  1
2019 Chartoumpekis DV, Ziros PG, Chen JG, Groopman JD, Kensler TW, Sykiotis GP. Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. PMID 30735751 DOI: 10.1016/j.fct.2019.02.004  1
2019 Yagishita Y, Uruno A, Chartoumpekis DV, Kensler TW, Yamamoto M. Nrf2 represses the onset of type 1 diabetes in non-obese diabetic mice. The Journal of Endocrinology. PMID 30625116 DOI: 10.1530/JOE-18-0355  0.4
2018 Lippman SM, Abate-Shen C, Colbert Maresso KL, Colditz GA, Dannenberg AJ, Davidson NE, Disis ML, DuBois RN, Szabo E, Giuliano AR, Hait WN, Lee JJ, Kensler TW, Kramer BS, Limburg P, et al. AACR White Paper: Shaping the Future of Cancer Prevention - A Roadmap for Advancing Science and Public Health. Cancer Prevention Research (Philadelphia, Pa.). 11: 735-778. PMID 30530635 DOI: 10.1158/1940-6207.CAPR-18-0421  1
2018 Ziros PG, Habeos I, Chartoumpekis DV, Ntalampyra E, Somm E, Renaud CO, Bongiovanni M, Trougakos IP, Yamamoto M, Kensler TW, Santisteban P, Carrasco N, Ris-Stalpers C, Amendola E, Liao XH, et al. The NFE2-related transcription factor 2 (Nrf2) coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland. Thyroid : Official Journal of the American Thyroid Association. PMID 29742982 DOI: 10.1089/thy.2018.0018  0.4
2018 Yamamoto M, Kensler TW, Motohashi H. The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis. Physiological Reviews. 98: 1169-1203. PMID 29717933 DOI: 10.1152/physrev.00023.2017  0.4
2018 Chartoumpekis DV, Yagishita Y, Fazzari M, Palliyaguru DL, Rao UN, Zaravinos A, Khoo NK, Schopfer FJ, Weiss KR, Michalopoulos GK, Sipula I, O'Doherty RM, Kensler TW, Wakabayashi N. Nrf2 prevents Notch-induced insulin resistance and tumorigenesis in mice. Jci Insight. 3. PMID 29515034 DOI: 10.1172/jci.insight.97735  0.72
2018 Chartoumpekis DV, Palliyaguru DL, Wakabayashi N, Fazzari M, Khoo NK, Schopfer FJ, Sipula I, Yagishita Y, Michalopoulos GK, O'Doherty RM, Kensler TW. Nrf2 deletion from adipocytes, but not hepatocytes, potentiates systemic metabolic dysfunction after long-term high-fat diet-induced obesity in mice. American Journal of Physiology. Endocrinology and Metabolism. PMID 29486138 DOI: 10.1152/ajpendo.00311.2017  0.72
2018 Wible RS, Ramanathan C, Sutter CH, Olesen KM, Kensler TW, Liu AC, Sutter TR. NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in. Elife. 7. PMID 29481323 DOI: 10.7554/eLife.31656  0.44
2018 Chen T, Qian G, Fan C, Sun Y, Wang J, Lu P, Xue X, Wu Y, Zhang Q, Jin Y, Wu Y, Gan Y, Lu J, Kensler TW, Groopman JD, et al. Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer. Hepatoma Research. 4. PMID 29479565 DOI: 10.20517/2394-5079.2017.50  1
2018 Palliyaguru DL, Yuan JM, Kensler TW, Fahey JW. Isothiocyanates: Translating the Power of Plants to People. Molecular Nutrition & Food Research. PMID 29468815 DOI: 10.1002/mnfr.201700965  0.32
2018 Wible RS, Tran QT, Fathima S, Sutter CH, Kensler TW, Sutter TR. Pharmacogenomics of chemically distinct classes of Keap1-Nrf2 activators identify common and unique gene, protein, and pathway responses in vivo. Molecular Pharmacology. PMID 29367259 DOI: 10.1124/mol.117.110262  0.44
2017 Dinkova-Kostova AT, Fahey JW, Kostov RV, Kensler TW. KEAP1 and Done? Targeting the NRF2 Pathway with Sulforaphane. Trends in Food Science & Technology. 69: 257-269. PMID 29242678 DOI: 10.1016/j.tifs.2017.02.002  0.32
2017 Reddy NM, Kleeberger SR, Kensler TW, Yamamoto M, Hassoun PM, Reddy SP. Correction: Disruption of Nrf2 Impairs the Resolution of Hyperoxia-Induced Acute Lung Injury and Inflammation in Mice. Journal of Immunology (Baltimore, Md. : 1950). 198: 3755. PMID 28416718 DOI: 10.4049/jimmunol.1700291  0.4
2017 Copple IM, Dinkova-Kostova AT, Kensler TW, Liby KT, Wigley WC. NRF2 as an Emerging Therapeutic Target. Oxidative Medicine and Cellular Longevity. 2017: 8165458. PMID 28250892 DOI: 10.1155/2017/8165458  0.4
2017 Livingstone MC, Johnson NM, Roebuck BD, Kensler TW, Groopman JD. Profound changes in miRNA expression during cancer initiation by aflatoxin B1 and their abrogation by the chemopreventive triterpenoid CDDO-Im. Molecular Carcinogenesis. PMID 28218475 DOI: 10.1002/mc.22635  1
2016 Tan RJ, Chartoumpekis DV, Rush BM, Zhou D, Fu H, Kensler TW, Liu Y. Keap1 hypomorphism protects against ischemic and obstructive kidney disease. Scientific Reports. 6: 36185. PMID 27804998 DOI: 10.1038/srep36185  0.4
2016 Palliyaguru DL, Chartoumpekis DV, Wakabayashi N, Skoko JJ, Yagishita Y, Singh SV, Kensler TW. Withaferin A induces Nrf2-dependent protection against liver injury: role of Keap1-independent mechanisms. Free Radical Biology & Medicine. PMID 27717869 DOI: 10.1016/j.freeradbiomed.2016.10.003  1
2016 Davidson NE, Armstrong SA, Coussens LM, Cruz-Correa MR, DeBerardinis RJ, Doroshow JH, Foti M, Hwu P, Kensler TW, Morrow M, Mulligan CG, Pao W, Platz EA, Smith TJ, Willman CL. AACR Cancer Progress Report 2016. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 22: S1-S137. PMID 27697776 DOI: 10.1158/1078-0432.CCR-16-1993  1
2016 Bauman JE, Zang Y, Sen M, Li C, Wang L, Egner PA, Fahey JW, Normolle DP, Grandis JR, Kensler TW, Johnson DE. Prevention of Carcinogen-Induced Oral Cancer by Sulforaphane. Cancer Prevention Research (Philadelphia, Pa.). PMID 27339168 DOI: 10.1158/1940-6207.CAPR-15-0290  1
2016 Taguchi K, Takaku M, Egner PA, Morita M, Kaneko T, Mashimo T, Kensler TW, Yamamoto M. Generation of A New Model Rat: Nrf2 Knockout Rats Are Sensitive to Aflatoxin B1 Toxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27071940 DOI: 10.1093/toxsci/kfw065  1
2016 Yang L, Palliyaguru DL, Kensler TW. Frugal chemoprevention: targeting Nrf2 with foods rich in sulforaphane. Seminars in Oncology. 43: 146-53. PMID 26970133 DOI: 10.1053/j.seminoncol.2015.09.013  0.32
2016 Shelar SB, Narasimhan M, Shanmugam G, Litovsky SH, Gounder SS, Karan G, Arulvasu C, Kensler TW, Hoidal JR, Darley-Usmar VM, Rajasekaran NS. Disruption of nuclear factor (erythroid-derived-2)-like 2 antioxidant signaling: a mechanism for impaired activation of stem cells and delayed regeneration of skeletal muscle. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26839378 DOI: 10.1096/fj.201500153  1
2016 Kensler TW, Spira A, Garber JE, Szabo E, Lee JJ, Dong Z, Dannenberg AJ, Hait WN, Blackburn E, Davidson NE, Foti M, Lippman SM. Transforming Cancer Prevention through Precision Medicine and Immune-oncology. Cancer Prevention Research (Philadelphia, Pa.). 9: 2-10. PMID 26744449 DOI: 10.1158/1940-6207.CAPR-15-0406  1
2016 Meyskens FL, Mukhtar H, Rock CL, Cuzick J, Kensler TW, Yang CS, Ramsey SD, Lippman SM, Alberts DS. Cancer Prevention: Obstacles, Challenges and the Road Ahead. Journal of the National Cancer Institute. 108. PMID 26547931 DOI: 10.1093/jnci/djv309  1
2015 Slocum SL, Skoko JJ, Wakabayashi N, Aja S, Yamamoto M, Kensler TW, Chartoumpekis DV. Keap1/Nrf2 pathway activation leads to a repressed hepatic gluconeogenic and lipogenic program in mice on a high-fat diet. Archives of Biochemistry and Biophysics. PMID 26701603 DOI: 10.1016/j.abb.2015.11.040  0.96
2015 Chartoumpekis DV, Wakabayashi N, Kensler TW. Keap1/Nrf2 pathway in the frontiers of cancer and non-cancer cell metabolism. Biochemical Society Transactions. 43: 639-44. PMID 26551705 DOI: 10.1042/BST20150049  0.72
2015 Yang J, Zhu J, Zhang YH, Chen YS, Ding LL, Kensler TW, Chen JG. Lung Cancer in a Rural Area of China: Rapid Rise in Incidence and Poor Improvement in Survival. Asian Pacific Journal of Cancer Prevention : Apjcp. 16: 7295-302. PMID 26514527  0.4
2015 Chartoumpekis DV, Palliyaguru DL, Wakabayashi N, Khoo NK, Schoiswohl G, O'Doherty RM, Kensler TW. Notch intracellular domain overexpression in adipocytes confers lipodystrophy in mice. Molecular Metabolism. 4: 543-50. PMID 26137442 DOI: 10.1016/j.molmet.2015.04.004  1
2015 Wakabayashi N, Chartoumpekis DV, Kensler TW. Crosstalk between Nrf2 and Notch signaling. Free Radical Biology & Medicine. 88: 158-67. PMID 26003520 DOI: 10.1016/j.freeradbiomed.2015.05.017  0.72
2015 Sheth SH, Johnson DE, Kensler TW, Bauman JE. Chemoprevention targets for tobacco-related head and neck cancer: past lessons and future directions. Oral Oncology. 51: 557-64. PMID 25868717 DOI: 10.1016/j.oraloncology.2015.02.101  1
2014 Wu F, Mitchell NJ, Male D, Kensler TW. Reduced foodborne toxin exposure is a benefit of improving dietary diversity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 141: 329-34. PMID 25015663 DOI: 10.1093/toxsci/kfu137  1
2014 Skoko JJ, Wakabayashi N, Noda K, Kimura S, Tobita K, Shigemura N, Tsujita T, Yamamoto M, Kensler TW. Loss of Nrf2 in mice evokes a congenital intrahepatic shunt that alters hepatic oxygen and protein expression gradients and toxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 141: 112-9. PMID 24924401 DOI: 10.1093/toxsci/kfu109  0.72
2014 Egner PA, Chen JG, Zarth AT, Ng DK, Wang JB, Kensler KH, Jacobson LP, Muñoz A, Johnson JL, Groopman JD, Fahey JW, Talalay P, Zhu J, Chen TY, Qian GS, ... ... Kensler TW, et al. Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. Cancer Prevention Research (Philadelphia, Pa.). 7: 813-23. PMID 24913818 DOI: 10.1158/1940-6207.CAPR-14-0103  1
2014 Kensler KH, Slocum SL, Chartoumpekis DV, Dolan PM, Johnson NM, Ilic Z, Crawford DR, Sell S, Groopman JD, Kensler TW, Egner PA. Genetic or pharmacologic activation of Nrf2 signaling fails to protect against aflatoxin genotoxicity in hypersensitive GSTA3 knockout mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 139: 293-300. PMID 24675090 DOI: 10.1093/toxsci/kfu056  1
2014 Johnson NM, Egner PA, Baxter VK, Sporn MB, Wible RS, Sutter TR, Groopman JD, Kensler TW, Roebuck BD. Complete protection against aflatoxin B(1)-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature, and genotoxicity threshold. Cancer Prevention Research (Philadelphia, Pa.). 7: 658-65. PMID 24662598 DOI: 10.1158/1940-6207.CAPR-13-0430  1
2014 Wakabayashi N, Skoko JJ, Chartoumpekis DV, Kimura S, Slocum SL, Noda K, Palliyaguru DL, Fujimuro M, Boley PA, Tanaka Y, Shigemura N, Biswal S, Yamamoto M, Kensler TW. Notch-Nrf2 axis: regulation of Nrf2 gene expression and cytoprotection by notch signaling. Molecular and Cellular Biology. 34: 653-63. PMID 24298019 DOI: 10.1128/MCB.01408-13  1
2014 Chen JG, Kensler TW. Changing rates for liver and lung cancers in Qidong, China. Chemical Research in Toxicology. 27: 3-6. PMID 24215631 DOI: 10.1021/tx400313j  1
2014 Liu M, Reddy NM, Higbee EM, Potteti HR, Noel S, Racusen L, Kensler TW, Sporn MB, Reddy SP, Rabb H. The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia-reperfusion injury in mice. Kidney International. 85: 134-41. PMID 24088953 DOI: 10.1038/ki.2013.357  1
2013 Chen JG, Egner PA, Ng D, Jacobson LP, Muñoz A, Zhu YR, Qian GS, Wu F, Yuan JM, Groopman JD, Kensler TW. Reduced aflatoxin exposure presages decline in liver cancer mortality in an endemic region of China. Cancer Prevention Research (Philadelphia, Pa.). 6: 1038-45. PMID 23963804 DOI: 10.1158/1940-6207.CAPR-13-0168  1
2013 Vitturi DA, Chen CS, Woodcock SR, Salvatore SR, Bonacci G, Koenitzer JR, Stewart NA, Wakabayashi N, Kensler TW, Freeman BA, Schopfer FJ. Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase. The Journal of Biological Chemistry. 288: 25626-37. PMID 23878198 DOI: 10.1074/jbc.M113.486282  1
2013 Yang L, Zahid M, Liao Y, Rogan EG, Cavalieri EL, Davidson NE, Yager JD, Visvanathan K, Groopman JD, Kensler TW. Reduced formation of depurinating estrogen-DNA adducts by sulforaphane or KEAP1 disruption in human mammary epithelial MCF-10A cells. Carcinogenesis. 34: 2587-92. PMID 23843041 DOI: 10.1093/carcin/bgt246  1
2013 Kannan S, Muthusamy VR, Whitehead KJ, Wang L, Gomes AV, Litwin SE, Kensler TW, Abel ED, Hoidal JR, Rajasekaran NS. Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy. Cardiovascular Research. 100: 63-73. PMID 23761402 DOI: 10.1093/cvr/cvt150  1
2013 Uruno A, Furusawa Y, Yagishita Y, Fukutomi T, Muramatsu H, Negishi T, Sugawara A, Kensler TW, Yamamoto M. The Keap1-Nrf2 system prevents onset of diabetes mellitus. Molecular and Cellular Biology. 33: 2996-3010. PMID 23716596 DOI: 10.1128/MCB.00225-13  0.4
2013 Volonte D, Liu Z, Musille PM, Stoppani E, Wakabayashi N, Di YP, Lisanti MP, Kensler TW, Galbiati F. Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence. Molecular Biology of the Cell. 24: 1852-62. PMID 23637463 DOI: 10.1091/mbc.E12-09-0666  1
2013 Fahey JW, Kensler TW. Health span extension through green chemoprevention. The Virtual Mentor : Vm. 15: 311-8. PMID 23566780 DOI: 10.1001/virtualmentor.2013.15.4.stas1-1304  0.32
2013 Kawamura T, Wakabayashi N, Shigemura N, Huang CS, Masutani K, Tanaka Y, Noda K, Peng X, Takahashi T, Billiar TR, Okumura M, Toyoda Y, Kensler TW, Nakao A. Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. American Journal of Physiology. Lung Cellular and Molecular Physiology. 304: L646-56. PMID 23475767 DOI: 10.1152/ajplung.00164.2012  0.72
2013 Chartoumpekis DV, Kensler TW. New player on an old field; the keap1/Nrf2 pathway as a target for treatment of type 2 diabetes and metabolic syndrome. Current Diabetes Reviews. 9: 137-45. PMID 23363332  0.4
2013 Kensler TW, Egner PA, Agyeman AS, Visvanathan K, Groopman JD, Chen JG, Chen TY, Fahey JW, Talalay P. Keap1-nrf2 signaling: a target for cancer prevention by sulforaphane. Topics in Current Chemistry. 329: 163-77. PMID 22752583 DOI: 10.1007/128_2012_339  1
2013 Kaidery NA, Banerjee R, Yang L, Smirnova NA, Hushpulian DM, Liby KT, Williams CR, Yamamoto M, Kensler TW, Ratan RR, Sporn MB, Beal MF, Gazaryan IG, Thomas B. Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease. Antioxidants & Redox Signaling. 18: 139-57. PMID 22746536 DOI: 10.1089/ars.2011.4491  1
2012 Takaya K, Suzuki T, Motohashi H, Onodera K, Satomi S, Kensler TW, Yamamoto M. Validation of the multiple sensor mechanism of the Keap1-Nrf2 system Free Radical Biology and Medicine. 53: 817-827. PMID 22732183 DOI: 10.1016/j.freeradbiomed.2012.06.023  1
2012 Kageyama Y, Zhang Z, Roda R, Fukaya M, Wakabayashi J, Wakabayashi N, Kensler TW, Reddy PH, Iijima M, Sesaki H. Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage. The Journal of Cell Biology. 197: 535-51. PMID 22564413 DOI: 10.1083/jcb.201110034  0.72
2012 Meher AK, Sharma PR, Lira VA, Yamamoto M, Kensler TW, Yan Z, Leitinger N. Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance. Free Radical Biology & Medicine. 52: 1708-15. PMID 22370093 DOI: 10.1016/j.freeradbiomed.2012.02.022  1
2012 Weerachayaphorn J, Mennone A, Soroka CJ, Harry K, Hagey LR, Kensler TW, Boyer JL. Nuclear factor-E2-related factor 2 is a major determinant of bile acid homeostasis in the liver and intestine. American Journal of Physiology. Gastrointestinal and Liver Physiology. 302: G925-36. PMID 22345550 DOI: 10.1152/ajpgi.00263.2011  1
2012 Fahey JW, Wehage SL, Holtzclaw WD, Kensler TW, Egner PA, Shapiro TA, Talalay P. Protection of humans by plant glucosinolates: Efficiency of conversion of glucosinolates to isothiocyanates by the gastrointestinal microflora Cancer Prevention Research. 5: 603-611. PMID 22318753 DOI: 10.1158/1940-6207.CAPR-11-0538  1
2012 Fahey JW, Talalay P, Kensler TW. Notes from the field: "Green" chemoprevention as frugal medicine Cancer Prevention Research. 5: 179-188. PMID 22307565 DOI: 10.1158/1940-6207.CAPR-11-0572  1
2012 Kensler TW, Ng D, Carmella SG, Chen M, Jacobson LP, Muñoz A, Egner PA, Chen JG, Qian GS, Chen TY, Fahey JW, Talalay P, Groopman JD, Yuan JM, Hecht SS. Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China. Carcinogenesis. 33: 101-7. PMID 22045030 DOI: 10.1093/carcin/bgr229  1
2012 Wogan GN, Kensler TW, Groopman JD. Present and future directions of translational research on aflatoxin and hepatocellular carcinoma. A review. Food Additives & Contaminants. Part a, Chemistry, Analysis, Control, Exposure & Risk Assessment. 29: 249-57. PMID 21623489 DOI: 10.1080/19440049.2011.563370  1
2012 Agyeman AS, Chaerkady R, Shaw PG, Davidson NE, Visvanathan K, Pandey A, Kensler TW. Transcriptomic and proteomic profiling of KEAP1 disrupted and sulforaphane-treated human breast epithelial cells reveals common expression profiles. Breast Cancer Research and Treatment. 132: 175-87. PMID 21597922 DOI: 10.1007/s10549-011-1536-9  1
2011 Tolstov YL, Knauer A, Chen JG, Kensler TW, Kingsley LA, Moore PS, Chang Y. Asymptomatic primary Merkel cell polyomavirus infection among adults. Emerging Infectious Diseases. 17: 1371-80. PMID 21801612 DOI: 10.3201/eid1708.110079  1
2011 Davidson NE, Kensler TW. "MAPping" the course of chemoprevention in breast cancer. The New England Journal of Medicine. 364: 2463-4. PMID 21639807 DOI: 10.1056/NEJMe1106052  1
2011 Zhang Z, Wakabayashi N, Wakabayashi J, Tamura Y, Song WJ, Sereda S, Clerc P, Polster BM, Aja SM, Pletnikov MV, Kensler TW, Shirihai OS, Iijima M, Hussain MA, Sesaki H. The dynamin-related GTPase Opa1 is required for glucose-stimulated ATP production in pancreatic beta cells. Molecular Biology of the Cell. 22: 2235-45. PMID 21551073 DOI: 10.1091/mbc.E10-12-0933  1
2011 Muñoz A, Chen JG, Egner PA, Marshall ML, Johnson JL, Schneider MF, Lu JH, Zhu YR, Wang JB, Chen TY, Kensler TW, Groopman JD. Predictive power of hepatitis B 1762T/1764A mutations in plasma for hepatocellular carcinoma risk in Qidong, China. Carcinogenesis. 32: 860-5. PMID 21474708 DOI: 10.1093/carcin/bgr055  1
2011 Egner PA, Chen JG, Wang JB, Wu Y, Sun Y, Lu JH, Zhu J, Zhang YH, Chen YS, Friesen MD, Jacobson LP, Muñoz A, Ng D, Qian GS, Zhu YR, ... ... Kensler TW, et al. Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China. Cancer Prevention Research (Philadelphia, Pa.). 4: 384-95. PMID 21372038 DOI: 10.1158/1940-6207.CAPR-10-0296  1
2011 Slocum SL, Kensler TW. Nrf2: control of sensitivity to carcinogens. Archives of Toxicology. 85: 273-84. PMID 21369766 DOI: 10.1007/s00204-011-0675-4  1
2011 You A, Nam CW, Wakabayashi N, Yamamoto M, Kensler TW, Kwak MK. Transcription factor Nrf2 maintains the basal expression of Mdm2: An implication of the regulation of p53 signaling by Nrf2. Archives of Biochemistry and Biophysics. 507: 356-64. PMID 21211512 DOI: 10.1016/j.abb.2010.12.034  1
2011 Kensler TW, Roebuck BD, Wogan GN, Groopman JD. Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology. Toxicological Sciences : An Official Journal of the Society of Toxicology. 120: S28-48. PMID 20881231 DOI: 10.1093/toxsci/kfq283  1
2010 Wakabayashi N, Shin S, Slocum SL, Agoston ES, Wakabayashi J, Kwak MK, Misra V, Biswal S, Yamamoto M, Kensler TW. Regulation of notch1 signaling by nrf2: implications for tissue regeneration. Science Signaling. 3: ra52. PMID 20628156 DOI: 10.1126/scisignal.2000762  1
2010 Yao Y, Brodie AM, Davidson NE, Kensler TW, Zhou Q. Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer. Breast Cancer Research and Treatment. 124: 585-91. PMID 20623181 DOI: 10.1007/s10549-010-1023-8  1
2010 Malhotra D, Portales-Casamar E, Singh A, Srivastava S, Arenillas D, Happel C, Shyr C, Wakabayashi N, Kensler TW, Wasserman WW, Biswal S. Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis. Nucleic Acids Research. 38: 5718-34. PMID 20460467 DOI: 10.1093/nar/gkq212  0.72
2010 Shah ZA, Li RC, Ahmad AS, Kensler TW, Yamamoto M, Biswal S, Doré S. The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 30: 1951-61. PMID 20442725 DOI: 10.1038/jcbfm.2010.53  1
2010 Wakabayashi N, Slocum SL, Skoko JJ, Shin S, Kensler TW. When NRF2 talks, who's listening? Antioxidants & Redox Signaling. 13: 1649-63. PMID 20367496 DOI: 10.1089/ars.2010.3216  1
2010 Shin DH, Park HM, Jung KA, Choi HG, Kim JA, Kim DD, Kim SG, Kang KW, Ku SK, Kensler TW, Kwak MK. The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis. Free Radical Biology & Medicine. 48: 1051-63. PMID 20096777 DOI: 10.1016/j.freeradbiomed.2010.01.021  1
2010 Zhou Q, Chaerkady R, Shaw PG, Kensler TW, Pandey A, Davidson NE. Screening for therapeutic targets of vorinostat by SILAC-based proteomic analysis in human breast cancer cells. Proteomics. 10: 1029-39. PMID 20049865 DOI: 10.1002/pmic.200900602  1
2010 Kensler TW, Wakabayashi N. Nrf2: friend or foe for chemoprevention? Carcinogenesis. 31: 90-9. PMID 19793802 DOI: 10.1093/carcin/bgp231  0.72
2010 Kwak MK, Kensler TW. Targeting NRF2 signaling for cancer chemoprevention. Toxicology and Applied Pharmacology. 244: 66-76. PMID 19732782 DOI: 10.1016/j.taap.2009.08.028  0.44
2010 Gruber F, Mayer H, Lengauer B, Mlitz V, Sanders JM, Kadl A, Bilban M, de Martin R, Wagner O, Kensler TW, Yamamoto M, Leitinger N, Tschachler E. NF-E2-related factor 2 regulates the stress response to UVA-1-oxidized phospholipids in skin cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 39-48. PMID 19720622 DOI: 10.1096/fj.09-133520  1
2009 Kensler TW, Groopman JD. Is it time to advance the chemoprevention of environmental carcinogenesis with microdosing trials? Cancer Prevention Research (Philadelphia, Pa.). 2: 1003-7. PMID 19952364 DOI: 10.1158/1940-6207.CAPR-09-0232  1
2009 Holland R, Navamal M, Velayutham M, Zweier JL, Kensler TW, Fishbein JC. Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones. Chemical Research in Toxicology. 22: 1427-34. PMID 19785463 DOI: 10.1021/tx900110n  1
2009 Wakabayashi J, Zhang Z, Wakabayashi N, Tamura Y, Fukaya M, Kensler TW, Iijima M, Sesaki H. The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice. The Journal of Cell Biology. 186: 805-16. PMID 19752021 DOI: 10.1083/jcb.200903065  0.72
2009 Reddy NM, Suryanarayana V, Kalvakolanu DV, Yamamoto M, Kensler TW, Hassoun PM, Kleeberger SR, Reddy SP. Innate immunity against bacterial infection following hyperoxia exposure is impaired in NRF2-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 183: 4601-8. PMID 19734219 DOI: 10.4049/jimmunol.0901754  1
2009 Shin S, Wakabayashi J, Yates MS, Wakabayashi N, Dolan PM, Aja S, Liby KT, Sporn MB, Yamamoto M, Kensler TW. Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide. European Journal of Pharmacology. 620: 138-44. PMID 19698707 DOI: 10.1016/j.ejphar.2009.08.022  1
2009 Reddy NM, Suryanaraya V, Yates MS, Kleeberger SR, Hassoun PM, Yamamoto M, Liby KT, Sporn MB, Kensler TW, Reddy SP. The triterpenoid CDDO-imidazolide confers potent protection against hyperoxic acute lung injury in mice. American Journal of Respiratory and Critical Care Medicine. 180: 867-74. PMID 19679692 DOI: 10.1164/rccm.200905-0670OC  1
2009 Usera AR, Dolan P, Kensler TW, Posner GH. 'Novel alkyl side chain sulfone 1α,25-dihydroxyvitamin D3 analogs: A comparison of in vitro antiproliferative activities and in vivo calcemic activities' Bioorganic and Medicinal Chemistry. 17: 5627-5631. PMID 19577932 DOI: 10.1016/j.bmc.2009.06.033  1
2009 Reddy NM, Kleeberger SR, Kensler TW, Yamamoto M, Hassoun PM, Reddy SP. Disruption of Nrf2 impairs the resolution of hyperoxia-induced acute lung injury and inflammation in mice. Journal of Immunology (Baltimore, Md. : 1950). 182: 7264-71. PMID 19454723 DOI: 10.4049/jimmunol.0804248  1
2009 Nagai N, Thimmulappa RK, Cano M, Fujihara M, Izumi-Nagai K, Kong X, Sporn MB, Kensler TW, Biswal S, Handa JT. Nrf2 is a critical modulator of the innate immune response in a model of uveitis. Free Radical Biology & Medicine. 47: 300-6. PMID 19410644 DOI: 10.1016/j.freeradbiomed.2009.04.033  0.4
2009 Yates MS, Tran QT, Dolan PM, Osburn WO, Shin S, McCulloch CC, Silkworth JB, Taguchi K, Yamamoto M, Williams CR, Liby KT, Sporn MB, Sutter TR, Kensler TW. Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. Carcinogenesis. 30: 1024-31. PMID 19386581 DOI: 10.1093/carcin/bgp100  1
2009 Blackford A, Parmigiani G, Kensler TW, Wolfgang C, Jones S, Zhang X, Parsons DW, Lin JCH, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Klein A, et al. Genetic mutations associated with Cigarette smoking in pancreatic cancer Cancer Research. 69: 3681-3688. PMID 19351817 DOI: 10.1158/0008-5472.CAN-09-0015  1
2009 An SS, Kim J, Ahn K, Trepat X, Drake KJ, Kumar S, Ling G, Purington C, Rangasamy T, Kensler TW, Mitzner W, Fredberg JJ, Biswal S. Cell stiffness, contractile stress and the role of extracellular matrix. Biochemical and Biophysical Research Communications. 382: 697-703. PMID 19327344 DOI: 10.1016/j.bbrc.2009.03.118  0.4
2009 Roebuck BD, Johnson DN, Sutter CH, Egner PA, Scholl PF, Friesen MD, Baumgartner KJ, Ware NM, Bodreddigari S, Groopman JD, Kensler TW, Sutter TR. Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat. Toxicological Sciences : An Official Journal of the Society of Toxicology. 109: 41-9. PMID 19168568 DOI: 10.1093/toxsci/kfp003  1
2009 Tran QT, Xu L, Phan V, Goodwin SB, Rahman M, Jin VX, Sutter CH, Roebuck BD, Kensler TW, George EO, Sutter TR. Chemical genomics of cancer chemopreventive dithiolethiones. Carcinogenesis. 30: 480-6. PMID 19126641 DOI: 10.1093/carcin/bgn292  1
2009 Sussan TE, Rangasamy T, Blake DJ, Malhotra D, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, Sporn MB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, et al. Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 250-5. PMID 19104057 DOI: 10.1073/pnas.0804333106  1
2009 Singh A, Ling G, Suhasini AN, Zhang P, Yamamoto M, Navas-Acien A, Cosgrove G, Tuder RM, Kensler TW, Watson WH, Biswal S. Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs. Free Radical Biology & Medicine. 46: 376-86. PMID 19027064 DOI: 10.1016/j.freeradbiomed.2008.10.026  1
2008 Colburn NH, Kensler TW. Targeting transcription factors for cancer prevention--the case of Nrf2. Cancer Prevention Research (Philadelphia, Pa.). 1: 153-5. PMID 19138949 DOI: 10.1158/1940-6207.CAPR-08-0025  1
2008 Williams MA, Rangasamy T, Bauer SM, Killedar S, Karp M, Kensler TW, Yamamoto M, Breysse P, Biswal S, Georas SN. Disruption of the transcription factor Nrf2 promotes pro-oxidative dendritic cells that stimulate Th2-like immunoresponsiveness upon activation by ambient particulate matter. Journal of Immunology (Baltimore, Md. : 1950). 181: 4545-59. PMID 18802057  1
2008 Egner PA, Kensler TW, Chen JG, Gange SJ, Groopman JD, Friesen MD. Quantification of sulforaphane mercapturic acid pathway conjugates in human urine by high-performance liquid chromatography and isotope-dilution tandem mass spectrometry. Chemical Research in Toxicology. 21: 1991-6. PMID 18729326 DOI: 10.1021/tx800210k  1
2008 Liby K, Yore MM, Roebuck BD, Baumgartner KJ, Honda T, Sundararajan C, Yoshizawa H, Gribble GW, Williams CR, Risingsong R, Royce DB, Dinkova-Kostova AT, Stephenson KK, Egner PA, Yates MS, ... ... Kensler TW, et al. A novel acetylenic tricyclic bis-(cyano enone) potently induces phase 2 cytoprotective pathways and blocks liver carcinogenesis induced by aflatoxin Cancer Research. 68: 6727-6733. PMID 18701497 DOI: 10.1158/0008-5472.CAN-08-1123  1
2008 Bransfield LA, Rennie A, Visvanathan K, Odwin SA, Kensler TW, Yager JD, Friesen MD, Groopman JD. Formation of two novel estrogen guanine adducts and HPLC/MS detection of 4-hydroxyestradiol-N7-guanine in human urine. Chemical Research in Toxicology. 21: 1622-30. PMID 18582124 DOI: 10.1021/tx800145w  1
2008 Osburn WO, Yates MS, Dolan PD, Chen S, Liby KT, Sporn MB, Taguchi K, Yamamoto M, Kensler TW. Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 104: 218-27. PMID 18417483 DOI: 10.1093/toxsci/kfn079  1
2008 Bodreddigari S, Jones LK, Egner PA, Groopman JD, Sutter CH, Roebuck BD, Guengerich FP, Kensler TW, Sutter TR. Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3. Chemical Research in Toxicology. 21: 1134-42. PMID 18416522 DOI: 10.1021/tx7004458  1
2008 Pearson KJ, Lewis KN, Price NL, Chang JW, Perez E, Cascajo MV, Tamashiro KL, Poosala S, Csiszar A, Ungvari Z, Kensler TW, Yamamoto M, Egan JM, Longo DL, Ingram DK, et al. Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proceedings of the National Academy of Sciences of the United States of America. 105: 2325-30. PMID 18287083 DOI: 10.1073/pnas.0712162105  1
2008 Johnson DN, Egner PA, Obrian G, Glassbrook N, Roebuck BD, Sutter TR, Payne GA, Kensler TW, Groopman JD. Quantification of urinary aflatoxin B1 dialdehyde metabolites formed by aflatoxin aldehyde reductase using isotope dilution tandem mass spectrometry. Chemical Research in Toxicology. 21: 752-60. PMID 18266327 DOI: 10.1021/tx700397n  1
2008 Osburn WO, Kensler TW. Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults. Mutation Research. 659: 31-9. PMID 18164232 DOI: 10.1016/j.mrrev.2007.11.006  0.88
2008 Groopman JD, Kensler TW, Wild CP. Protective interventions to prevent aflatoxin-induced carcinogenesis in developing countries. Annual Review of Public Health. 29: 187-203. PMID 17914931 DOI: 10.1146/annurev.publhealth.29.020907.090859  1
2007 Petersen KS, Dolan PM, Kensler TW, Peleg S, Posner GH. Low-calcemic, highly antiproliferative, 23-oxa ether analogs of the natural hormone 1α,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation Journal of Medicinal Chemistry. 50: 5824-5832. PMID 17924616 DOI: 10.1021/jm070882d  1
2007 Papaiahgari S, Yerrapureddy A, Reddy SR, Reddy NM, Dodd-O JM, Crow MT, Grigoryev DN, Barnes K, Tuder RM, Yamamoto M, Kensler TW, Biswal S, Mitzner W, Hassoun PM, Reddy SP. Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice. American Journal of Respiratory and Critical Care Medicine. 176: 1222-35. PMID 17901416 DOI: 10.1164/rccm.200701-060OC  1
2007 Reddy NM, Kleeberger SR, Yamamoto M, Kensler TW, Scollick C, Biswal S, Reddy SP. Genetic dissection of the Nrf2-dependent redox signaling-regulated transcriptional programs of cell proliferation and cytoprotection. Physiological Genomics. 32: 74-81. PMID 17895394 DOI: 10.1152/physiolgenomics.00126.2007  1
2007 Manandhar S, Cho JM, Kim JA, Kensler TW, Kwak MK. Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes. European Journal of Pharmacology. 577: 17-27. PMID 17854798 DOI: 10.1016/j.ejphar.2007.08.018  1
2007 Thimmulappa RK, Fuchs RJ, Malhotra D, Scollick C, Traore K, Bream JH, Trush MA, Liby KT, Sporn MB, Kensler TW, Biswal S. Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils. Antioxidants & Redox Signaling. 9: 1963-70. PMID 17822364 DOI: 10.1089/ars.2007.1745  1
2007 Yates MS, Kensler TW. Keap1 eye on the target: chemoprevention of liver cancer. Acta Pharmacologica Sinica. 28: 1331-42. PMID 17723167 DOI: 10.1111/j.1745-7254.2007.00688.x  0.96
2007 Shin S, Wakabayashi N, Misra V, Biswal S, Lee GH, Agoston ES, Yamamoto M, Kensler TW. NRF2 modulates aryl hydrocarbon receptor signaling: influence on adipogenesis. Molecular and Cellular Biology. 27: 7188-97. PMID 17709388 DOI: 10.1128/MCB.00915-07  0.72
2007 Kwak MK, Cho JM, Huang B, Shin S, Kensler TW. Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells. Free Radical Biology & Medicine. 43: 809-17. PMID 17664144 DOI: 10.1016/j.freeradbiomed.2007.05.029  0.72
2007 Osburn WO, Karim B, Dolan PM, Liu G, Yamamoto M, Huso DL, Kensler TW. Increased colonic inflammatory injury and formation of aberrant crypt foci in Nrf2-deficient mice upon dextran sulfate treatment. International Journal of Cancer. 121: 1883-91. PMID 17631644 DOI: 10.1002/ijc.22943  0.88
2007 Wang J, Fields J, Zhao C, Langer J, Thimmulappa RK, Kensler TW, Yamamoto M, Biswal S, Doré S. Role of Nrf2 in protection against intracerebral hemorrhage injury in mice. Free Radical Biology & Medicine. 43: 408-14. PMID 17602956 DOI: 10.1016/j.freeradbiomed.2007.04.020  1
2007 Usera AR, Dolan PM, Kensler TW, Posner GH. Antiproliferative, low-calcemic, fluorinated sulfone analogs of 1α,25-dihydroxyvitamin D3: Chemical synthesis and biological evaluation Bioorganic and Medicinal Chemistry. 15: 5509-5518. PMID 17560112 DOI: 10.1016/j.bmc.2007.05.051  1
2007 Chen JG, Kuang SY, Egner PA, Lu JH, Zhu YR, Wang JB, Zhang BC, Chen TY, Muñoz A, Kensler TW, Groopman JD. Acceleration to death from liver cancer in people with hepatitis B viral mutations detected in plasma by mass spectrometry. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 16: 1213-8. PMID 17548687 DOI: 10.1158/1055-9965.EPI-06-0905  1
2007 Kwak MK, Huang B, Chang H, Kim JA, Kensler TW. Tissue specific increase of the catalytic subunits of the 26S proteasome by indirect antioxidant dithiolethione in mice: enhanced activity for degradation of abnormal protein. Life Sciences. 80: 2411-20. PMID 17521679 DOI: 10.1016/j.lfs.2007.04.014  0.44
2007 Yates MS, Kensler TW. Chemopreventive promise of targeting the Nrf2 pathway. Drug News & Perspectives. 20: 109-17. PMID 17440634 DOI: 10.1358/dnp.2007.20.2.108343  0.96
2007 Reddy NM, Kleeberger SR, Cho HY, Yamamoto M, Kensler TW, Biswal S, Reddy SP. Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants. American Journal of Respiratory Cell and Molecular Biology. 37: 3-8. PMID 17413030 DOI: 10.1165/rcmb.2007-0004RC  1
2007 Fahey JW, Kensler TW. Role of dietary supplements/nutraceuticals in chemoprevention through induction of cytoprotective enzymes. Chemical Research in Toxicology. 20: 572-6. PMID 17362031 DOI: 10.1021/tx7000459  0.32
2007 Cornblatt BS, Ye L, Dinkova-Kostova AT, Erb M, Fahey JW, Singh NK, Chen MSA, Stierer T, Garrett-Mayer E, Argani P, Davidson NE, Talalay P, Kensler TW, Visvanathan K. Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast Carcinogenesis. 28: 1485-1490. PMID 17347138 DOI: 10.1093/carcin/bgm049  1
2007 Simonich MT, Egner PA, Roebuck BD, Orner GA, Jubert C, Pereira C, Groopman JD, Kensler TW, Dashwood RH, Williams DE, Bailey GS. Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat. Carcinogenesis. 28: 1294-302. PMID 17290047 DOI: 10.1093/carcin/bgm027  1
2007 Gong J, Vaidyanathan VG, Yu X, Kensler TW, Peterson LA, Sturla SJ. Depurinating acylfulvene-DNA adducts: characterizing cellular chemical reactions of a selective antitumor agent. Journal of the American Chemical Society. 129: 2101-11. PMID 17256933 DOI: 10.1021/ja0665951  1
2007 Yates MS, Tauchi M, Katsuoka F, Flanders KC, Liby KT, Honda T, Gribble GW, Johnson DA, Johnson JA, Burton NC, Guilarte TR, Yamamoto M, Sporn MB, Kensler TW. Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes. Molecular Cancer Therapeutics. 6: 154-62. PMID 17237276 DOI: 10.1158/1535-7163.MCT-06-0516  1
2007 Posner GH, Suh BC, Petersen KS, Dolan P, Agoston ES, Kensler TW, Koh JT, Peleg S. Difluoromethyl analogs of the natural hormone 1α,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation Journal of Steroid Biochemistry and Molecular Biology. 103: 213-221. PMID 17218093 DOI: 10.1016/j.jsbmb.2006.12.024  1
2007 Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annual Review of Pharmacology and Toxicology. 47: 89-116. PMID 16968214 DOI: 10.1146/annurev.pharmtox.46.120604.141046  0.72
2006 Peleg S, Petersen KS, Suh BC, Dolan P, Agoston ES, Kensler TW, Posner GH. Low-calcemic, highly antiproliferative, 1-difluoromethyl hybrid analogs of the natural hormone 1α,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation Journal of Medicinal Chemistry. 49: 7513-7517. PMID 17149880 DOI: 10.1021/jm0609925  1
2006 Thimmulappa RK, Scollick C, Traore K, Yates M, Trush MA, Liby KT, Sporn MB, Yamamoto M, Kensler TW, Biswal S. Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. Biochemical and Biophysical Research Communications. 351: 883-9. PMID 17097057 DOI: 10.1016/j.bbrc.2006.10.102  1
2006 Egner PA, Groopman JD, Wang JS, Kensler TW, Friesen MD. Quantification of aflatoxin-B1-N7-Guanine in human urine by high-performance liquid chromatography and isotope dilution tandem mass spectrometry. Chemical Research in Toxicology. 19: 1191-5. PMID 16978023 DOI: 10.1021/tx060108d  1
2006 Osburn WO, Wakabayashi N, Misra V, Nilles T, Biswal S, Trush MA, Kensler TW. Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion. Archives of Biochemistry and Biophysics. 454: 7-15. PMID 16962985 DOI: 10.1016/j.abb.2006.08.005  0.88
2006 Burton NC, Kensler TW, Guilarte TR. In vivo modulation of the Parkinsonian phenotype by Nrf2. Neurotoxicology. 27: 1094-100. PMID 16959318 DOI: 10.1016/j.neuro.2006.07.019  1
2006 Skipper PL, Trudel LJ, Kensler TW, Groopman JD, Egner PA, Liberman RG, Wogan GN, Tannenbaum SR. DNA adduct formation by 2,6-dimethyl-, 3,5-dimethyl-, and 3-ethylaniline in vivo in mice. Chemical Research in Toxicology. 19: 1086-90. PMID 16918249 DOI: 10.1021/tx060082q  1
2006 Yu X, Egner PA, Wakabayashi J, Wakabayashi N, Yamamoto M, Kensler TW. Nrf2-mediated induction of cytoprotective enzymes by 15-deoxy-Delta12,14-prostaglandin J2 is attenuated by alkenal/one oxidoreductase. The Journal of Biological Chemistry. 281: 26245-52. PMID 16857669 DOI: 10.1074/jbc.M604620200  1
2006 Singh A, Rangasamy T, Thimmulappa RK, Lee H, Osburn WO, Brigelius-Flohé R, Kensler TW, Yamamoto M, Biswal S. Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2. American Journal of Respiratory Cell and Molecular Biology. 35: 639-50. PMID 16794261 DOI: 10.1165/rcmb.2005-0325OC  0.88
2006 Sinishtaj S, Jeon HB, Dolan P, Kensler TW, Posner GH. Highly antiproliferative, low-calcemic, side-chain amide and hydroxamate analogs of the hormone 1α,25-dihydroxyvitamin D3 Bioorganic and Medicinal Chemistry. 14: 6341-6348. PMID 16765598 DOI: 10.1016/j.bmc.2006.05.050  1
2006 Yates MS, Kwak MK, Egner PA, Groopman JD, Bodreddigari S, Sutter TR, Baumgartner KJ, Roebuck BD, Liby KT, Yore MM, Honda T, Gribble GW, Sporn MB, Kensler TW. Potent protection against aflatoxin-induced tumorigenesis through induction of Nrf2-regulated pathways by the triterpenoid 1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole. Cancer Research. 66: 2488-94. PMID 16489057 DOI: 10.1158/0008-5472.CAN-05-3823  1
2006 Agoston ES, Hatcher MA, Kensler TW, Posner GH. Vitamin D analogs as anti-carcinogenic agents Anti-Cancer Agents in Medicinal Chemistry. 6: 53-71. PMID 16475927 DOI: 10.2174/187152006784111369  1
2005 Groopman JD, Johnson D, Kensler TW. Aflatoxin and hepatitis B virus biomarkers: a paradigm for complex environmental exposures and cancer risk. Cancer Biomarkers : Section a of Disease Markers. 1: 5-14. PMID 17192028  1
2004 Dick RA, Yu X, Kensler TW. NADPH alkenal/one oxidoreductase activity determines sensitivity of cancer cells to the chemotherapeutic alkylating agent irofulven. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 1492-9. PMID 14977853  1
2004 Dick RA, Kensler TW. The catalytic and kinetic mechanisms of NADPH-dependent alkenal/one oxidoreductase. The Journal of Biological Chemistry. 279: 17269-77. PMID 14966122 DOI: 10.1074/jbc.M400427200  1
2002 Dick RA, Kensler TW. Chemoprotective potential of phase 2 enzyme inducers. Expert Review of Anticancer Therapy. 2: 581-92. PMID 12382526 DOI: 10.1586/14737140.2.5.581  1
2001 Nelson WG, De Marzo AM, Deweese TL, Lin X, Brooks JD, Putzi MJ, Nelson CP, Groopman JD, Kensler TW. Preneoplastic prostate lesions: an opportunity for prostate cancer prevention. Annals of the New York Academy of Sciences. 952: 135-44. PMID 11795433  1
2001 Parsons JK, Nelson CP, Gage WR, Nelson WG, Kensler TW, De Marzo AM. GSTA1 expression in normal, preneoplastic, and neoplastic human prostate tissue. The Prostate. 49: 30-7. PMID 11550208 DOI: 10.1002/pros.1115  0.4
2001 Dick RA, Kwak MK, Sutter TR, Kensler TW. Antioxidative function and substrate specificity of NAD(P)H-dependent alkenal/one oxidoreductase. A new role for leukotriene B4 12-hydroxydehydrogenase/15-oxoprostaglandin 13-reductase. The Journal of Biological Chemistry. 276: 40803-10. PMID 11524419 DOI: 10.1074/jbc.M105487200  1
2001 Nelson CP, Kidd LC, Sauvageot J, Isaacs WB, De Marzo AM, Groopman JD, Nelson WG, Kensler TW. Protection against 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine cytotoxicity and DNA adduct formation in human prostate by glutathione S-transferase P1. Cancer Research. 61: 103-9. PMID 11196146  1
1999 Kensler TW, Tsuda H, Wogan GN. United States-Japan workshop on New Rodent Models for the Analysis and Prevention of Carcinogenesis. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 8: 1033-7. PMID 10566560  1
1996 Kensler TW, Groopman JD, Wogan GN. Use of carcinogen-DNA and carcinogen-protein adduct biomarkers for cohort selection and as modifiable end points in chemoprevention trials. Iarc Scientific Publications. 237-48. PMID 8923034  1
1994 Groopman JD, Wogan GN, Roebuck BD, Kensler TW. Molecular biomarkers for aflatoxins and their application to human cancer prevention. Cancer Research. 54: 1907s-1911s. PMID 8137310  1
1993 Groopman JD, Wild CP, Hasler J, Junshi C, Wogan GN, Kensler TW. Molecular epidemiology of aflatoxin exposures: validation of aflatoxin-N7-guanine levels in urine as a biomarker in experimental rat models and humans. Environmental Health Perspectives. 99: 107-13. PMID 8319607  1
1976 Kensler TW, Busby WF, Davidson NE, Wogan GN. Effect of hepatocarcinogens on the binding of glucocorticoid receptor complex in rat liver nuclei Cancer Research. 36: 4647-4651. PMID 1000507  1
1976 Kensler TW, Busby WF, Davidson NE, Wogan GN. Aflatoxin inhibition of glucocorticoid binding capacity of rat liver nuclei Bba - General Subjects. 437: 200-210. PMID 181075 DOI: 10.1016/0304-4165(76)90361-5  1
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