Anna Marie Pyle - Publications

Yale University, Columbia University 

210 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Li K, Zheng J, Wirawan M, Trinh NM, Fedorova O, Griffin PR, Pyle AM, Luo D. Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3). Nucleic Acids Research. PMID 34403472 DOI: 10.1093/nar/gkab712  1
2021 Mao T, Israelow B, Lucas C, Vogels CBF, Fedorova O, Breban MI, Menasche BL, Dong H, Linehan M, Wilen CB, Landry ML, Grubaugh ND, Pyle AM, Iwasaki A. A stem-loop RNA RIG-I agonist confers prophylactic and therapeutic protection against acute and chronic SARS-CoV-2 infection in mice. Biorxiv : the Preprint Server For Biology. PMID 34159330 DOI: 10.1101/2021.06.16.448754  1
2020 Jacobson ME, Becker KW, Palmer CR, Pastora LE, Fletcher RB, Collins KA, Fedorova O, Duvall CL, Pyle AM, Wilson JT. Structural Optimization of Polymeric Carriers to Enhance the Immunostimulatory Activity of Molecularly Defined RIG-I Agonists. Acs Central Science. 6: 2008-2022. PMID 33274278 DOI: 10.1021/acscentsci.0c00568  1
2020 Manigrasso J, Chillón I, Genna V, Vidossich P, Somarowthu S, Pyle AM, De Vivo M, Marcia M. Visualizing group II intron dynamics between the first and second steps of splicing. Nature Communications. 11: 2837. PMID 32503992 DOI: 10.1038/S41467-020-16741-4  1
2020 Guo LT, Adams RL, Wan H, Huston NC, Potapova O, Olson S, Gallardo CM, Graveley BR, Torbett BE, Pyle AM. Sequencing and structure probing of long RNAs using MarathonRT: a next-generation reverse transcriptase. Journal of Molecular Biology. PMID 32259542 DOI: 10.1016/J.Jmb.2020.03.022  1
2020 Rawling DC, Jagdmann GE, Potapova O, Pyle AM. Small-Molecule Antagonists of the RIG-I Innate Immune Receptor. Acs Chemical Biology. 15: 311-317. PMID 31944652 DOI: 10.1021/Acschembio.9B00810  0.01
2019 Ren X, Linehan MM, Iwasaki A, Pyle AM. RIG-I Recognition of RNA Targets: The Influence of Terminal Base Pair Sequence and Overhangs on Affinity and Signaling. Cell Reports. 29: 3807-3815.e3. PMID 31851914 DOI: 10.1016/J.Celrep.2019.11.052  1
2019 Dickey TH, Song B, Pyle AM. RNA binding activates RIG-I by releasing an autorepressed signaling domain. Science Advances. 5: eaax3641. PMID 31616790 DOI: 10.1126/Sciadv.Aax3641  1
2019 Jiang X, Muthusamy V, Fedorova O, Kong Y, Kim DJ, Bosenberg M, Pyle AM, Iwasaki A. Intratumoral delivery of RIG-I agonist SLR14 induces robust antitumor responses. The Journal of Experimental Medicine. PMID 31601678 DOI: 10.1084/Jem.20190801  1
2019 Van Zandt MC, Jagdmann GE, Whitehouse D, Ji MK, Savoy J, Potapova O, Cousido-Siah A, Mitschler A, Howard EI, Pyle AM, Podjarny AD. Discovery of N-substituted 3-amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic acids as highly potent third generation inhibitors of human arginase I and II. Journal of Medicinal Chemistry. PMID 31408339 DOI: 10.1021/Acs.Jmedchem.9B00931  1
2019 Adams RL, Huston NC, Tavares RCA, Pyle AM. Sensitive detection of structural features and rearrangements in long, structured RNA molecules. Methods in Enzymology. 623: 249-289. PMID 31239050 DOI: 10.1016/Bs.Mie.2019.04.002  1
2019 Tavares RCA, Pyle AM, Somarowthu S. Phylogenetic Analysis with Improved Parameters Reveals Conservation in lncRNA Structures. Journal of Molecular Biology. PMID 30890332 DOI: 10.1016/J.Jmb.2019.03.012  1
2019 Ren X, Linehan MM, Iwasaki A, Pyle AM. RIG-I Selectively Discriminates against 5'-Monophosphate RNA. Cell Reports. 26: 2019-2027.e4. PMID 30784585 DOI: 10.1016/J.Celrep.2019.01.107  1
2019 Elion DL, Jacobson ME, Hicks DJ, Rahman B, Sanchez V, Gonzales-Ericsson PI, Fedorova O, Pyle AM, Wilson JT, Cook RS. Abstract A187: RIG-I agonists reinforce antitumor adaptive immunity and decrease Treg activity in breast cancer Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-A187  1
2018 Fedorova O, Jagdmann GE, Adams RL, Yuan L, Van Zandt MC, Pyle AM. Small molecules that target group II introns are potent antifungal agents. Nature Chemical Biology. PMID 30323219 DOI: 10.1038/S41589-018-0142-0  1
2018 Elion DL, Jacobson ME, Hicks DJ, Rahman B, Sanchez V, Gonzalez-Ericsson PI, Fedorova O, Pyle AM, Wilson JT, Cook RS. Therapeutically active RIG-I agonist induces immunogenic tumor cell killing in breast cancers. Cancer Research. PMID 30224377 DOI: 10.1158/0008-5472.Can-18-0730  1
2018 Mihaylova VT, Kong Y, Fedorova O, Sharma L, Dela Cruz CS, Pyle AM, Iwasaki A, Foxman EF. Regional Differences in Airway Epithelial Cells Reveal Tradeoff between Defense against Oxidative Stress and Defense against Rhinovirus. Cell Reports. 24: 3000-3007.e3. PMID 30208323 DOI: 10.1016/J.Celrep.2018.08.033  1
2018 Schult P, Roth H, Adams RL, Mas C, Imbert L, Orlik C, Ruggieri A, Pyle AM, Lohmann V. microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site. Nature Communications. 9: 2613. PMID 29973597 DOI: 10.1038/S41467-018-05053-3  1
2018 Linehan MM, Dickey TH, Molinari ES, Fitzgerald ME, Potapova O, Iwasaki A, Pyle AM. A minimal RNA ligand for potent RIG-I activation in living mice. Science Advances. 4: e1701854. PMID 29492454 DOI: 10.1126/Sciadv.1701854  1
2018 Palmer CR, Jacobson ME, Fedorova O, Pyle AM, Wilson JT. Environmentally Triggerable Retinoic Acid-Inducible Gene I Agonists Using Synthetic Polymer Overhangs. Bioconjugate Chemistry. PMID 29350913 DOI: 10.1021/acs.bioconjchem.7b00697  1
2017 Zhao C, Liu F, Pyle AM. An ultra-processive, accurate reverse transcriptase encoded by a metazoan group II intron. Rna (New York, N.Y.). PMID 29109157 DOI: 10.1261/Rna.063479.117  1
2017 Zhou T, Ren X, Adams RL, Pyle AM. NS3 from HCV strain JFH-1 is an unusually robust helicase that is primed to bind and unwind viral RNA. Journal of Virology. PMID 29070684 DOI: 10.1128/Jvi.01253-17  1
2017 Dickey TH, Pyle AM. The SMAD3 transcription factor binds complex RNA structures with high affinity. Nucleic Acids Research. PMID 29036649 DOI: 10.1093/Nar/Gkx846  1
2017 Ren X, Gelinas AD, von Carlowitz I, Janjic N, Pyle AM. Structural basis for IL-1α recognition by a modified DNA aptamer that specifically inhibits IL-1α signaling. Nature Communications. 8: 810. PMID 28993621 DOI: 10.1038/S41467-017-00864-2  1
2017 Schlick T, Pyle A. RNA Structural Variability and Functional Versatility Challenges RNA Structural Modeling and Design. Biophysical Journal. PMID 28669406 DOI: 10.1016/J.Bpj.2017.06.040  1
2017 Zhao C, Pyle AM. The group II intron maturase: a reverse transcriptase and splicing factor go hand in hand. Current Opinion in Structural Biology. 47: 30-39. PMID 28528306 DOI: 10.1016/J.Sbi.2017.05.002  1
2017 Adams RL, Pirakitikulr N, Pyle AM. Functional RNA structures throughout the Hepatitis C Virus genome. Current Opinion in Virology. 24: 79-86. PMID 28511116 DOI: 10.1016/J.Coviro.2017.04.007  1
2017 Zhao C, Pyle AM. Structural Insights into the Mechanism of Group II Intron Splicing. Trends in Biochemical Sciences. PMID 28438387 DOI: 10.1016/J.Tibs.2017.03.007  1
2017 Fitzgerald ME, Rawling DC, Potapova O, Ren X, Kohlway A, Pyle AM. Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding. Nucleic Acids Research. 45: 1442-1454. PMID 28180316 DOI: 10.1093/Nar/Gkw816  1
2017 Schlick T, Pyle AM. Opportunities and Challenges in RNA Structural Modeling and Design. Biophysical Journal. PMID 28162235 DOI: 10.1016/J.Bpj.2016.12.037  1
2017 Liu F, Somarowthu S, Pyle AM. Visualizing the secondary and tertiary architectural domains of lncRNA RepA. Nature Chemical Biology. PMID 28068310 DOI: 10.1038/Nchembio.2272  1
2017 Pyle AM. Group II Intron Self-Splicing. Annual Review of Biophysics. 45: 183-205. PMID 27391926 DOI: 10.1146/Annurev-Biophys-062215-011149  0.01
2017 Ren X, Gelinas AD, Carlowitz Iv, Janjic N, Pyle AM. Structural basis for IL-1 alpha recognition by a modified DNA aptamer that specifically inhibits IL-1 alpha signaling. Nature Communications. 8: 810-810. DOI: 10.2210/Pdb5Uc6/Pdb  1
2016 Fitzgerald ME, Rawling DC, Potapova O, Ren X, Kohlway A, Pyle AM. Selective RNA targeting and regulated signaling by RIG-I is controlled by coordination of RNA and ATP binding. Nucleic Acids Research. PMID 27625396 DOI: 10.1093/nar/gkw816  1
2016 Chillón I, Pyle AM. Inverted repeat Alu elements in the human lincRNA-p21 adopt a conserved secondary structure that regulates RNA function. Nucleic Acids Research. PMID 27378782 DOI: 10.1093/Nar/Gkw599  1
2016 Molinari E, Bar H, Pyle AM, Patrizio P. Transcriptome analysis of human cumulus cells reveals hypoxia as the main determinant of follicular senescence. Molecular Human Reproduction. PMID 27268410 DOI: 10.1093/Molehr/Gaw038  0.01
2016 Zhao C, Pyle AM. Crystal structures of a group II intron maturase reveal a missing link in spliceosome evolution. Nature Structural & Molecular Biology. PMID 27136328 DOI: 10.1038/Nsmb.3224  1
2016 Lilley DM, Pyle AM. Editorial overview: Nucleic acids and their protein complexes. Current Opinion in Structural Biology. 36: vii-viii. PMID 26948825 DOI: 10.1016/J.Sbi.2016.02.002  0.01
2016 Pirakitikulr N, Kohlway A, Lindenbach BD, Pyle AM. The Coding Region of the HCV Genome Contains a Network of Regulatory RNA Structures. Molecular Cell. PMID 26924328 DOI: 10.1016/J.Molcel.2016.01.024  1
2016 Pyle AM, Schlick T. Challenges in RNA Structural Modeling and Design. Journal of Molecular Biology. PMID 26876599 DOI: 10.1016/J.Jmb.2016.02.012  1
2016 Chillon I, Somarowthu S, Liu F, Pyle AM. Abstract IA25: Regulatory control of lincRNA function through formation of complex RNA structural motifs Cancer Research. 76. DOI: 10.1158/1538-7445.Nonrna15-Ia25  1
2015 Zhao C, Rajashankar KR, Marcia M, Pyle AM. Crystal structure of group II intron domain 1 reveals a template for RNA assembly. Nature Chemical Biology. PMID 26502156 DOI: 10.1038/Nchembio.1949  1
2015 Rawling DC, Fitzgerald ME, Pyle AM. Establishing the role of ATP for the function of the RIG-I innate immune sensor. Elife. 4. PMID 26371557 DOI: 10.7554/Elife.09391  1
2015 Chillón I, Marcia M, Legiewicz M, Liu F, Somarowthu S, Pyle AM. Native Purification and Analysis of Long RNAs. Methods in Enzymology. 558: 3-37. PMID 26068736 DOI: 10.1016/Bs.Mie.2015.01.008  1
2015 Somarowthu S, Legiewicz M, Chillón I, Marcia M, Liu F, Pyle AM. HOTAIR forms an intricate and modular secondary structure. Molecular Cell. 58: 353-61. PMID 25866246 DOI: 10.1016/J.Molcel.2015.03.006  1
2015 Pyle AM. Rediscovering RNA. Rna (New York, N.Y.). 21: 714-5. PMID 25780205 DOI: 10.1261/rna.050807.115  1
2015 Foxman EF, Storer JA, Fitzgerald ME, Wasik BR, Hou L, Zhao H, Turner PE, Pyle AM, Iwasaki A. Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells. Proceedings of the National Academy of Sciences of the United States of America. 112: 827-32. PMID 25561542 DOI: 10.1073/Pnas.1411030112  1
2015 Rawling DC, Fitzgerald ME, Pyle AM. Author response: Establishing the role of ATP for the function of the RIG-I innate immune sensor Elife. DOI: 10.7554/Elife.09391.017  1
2015 Molinari E, Pyle A, Bar H, Patrizio P. RNA sequencing and immuno-fluorescence staining of cumulus cells associated with human oocyte senescence pathways Fertility and Sterility. 104: e200-e201. DOI: 10.1016/J.Fertnstert.2015.07.623  0.01
2014 Pyle AM. Looking at LncRNAs with the ribozyme toolkit. Molecular Cell. 56: 13-7. PMID 25280101 DOI: 10.1016/J.Molcel.2014.08.025  1
2014 Rawling DC, Kohlway AS, Luo D, Ding SC, Pyle AM. The RIG-I ATPase core has evolved a functional requirement for allosteric stabilization by the Pincer domain. Nucleic Acids Research. 42: 11601-11. PMID 25217590 DOI: 10.1093/Nar/Gku817  1
2014 Kohlway A, Pirakitikulr N, Ding SC, Yang F, Luo D, Lindenbach BD, Pyle AM. The linker region of NS3 plays a critical role in the replication and infectivity of hepatitis C virus. Journal of Virology. 88: 10970-4. PMID 24965468 DOI: 10.1128/Jvi.00745-14  1
2014 Fitzgerald ME, Rawling DC, Vela A, Pyle AM. An evolving arsenal: viral RNA detection by RIG-I-like receptors. Current Opinion in Microbiology. 20: 76-81. PMID 24912143 DOI: 10.1016/J.Mib.2014.05.004  1
2014 Rawling DC, Pyle AM. Parts, assembly and operation of the RIG-I family of motors. Current Opinion in Structural Biology. 25: 25-33. PMID 24878341 DOI: 10.1016/J.Sbi.2013.11.011  1
2014 Marcia M, Pyle AM. Principles of ion recognition in RNA: insights from the group II intron structures. Rna (New York, N.Y.). 20: 516-27. PMID 24570483 DOI: 10.1261/Rna.043414.113  1
2014 Fitzgerald ME, Vela A, Pyle AM. Dicer-related helicase 3 forms an obligate dimer for recognizing 22G-RNA. Nucleic Acids Research. 42: 3919-30. PMID 24435798 DOI: 10.1093/Nar/Gkt1383  1
2014 Somarowthu S, Legiewicz M, Keating KS, Pyle AM. Visualizing the ai5γ group IIB intron. Nucleic Acids Research. 42: 1947-58. PMID 24203709 DOI: 10.1093/Nar/Gkt1051  1
2014 Kohlway A, Pirakitikulr N, Barrera FN, Potapova O, Engelman DM, Pyle AM, Lindenbach BD. Hepatitis C virus RNA replication and virus particle assembly require specific dimerization of the NS4A protein transmembrane domain. Journal of Virology. 88: 628-42. PMID 24173222 DOI: 10.1128/Jvi.02052-13  1
2014 Molinari E, Patrizio P, Pyle A. Rna high throughput sequencing of cumulus cells reveals new pathways involved in human oocyte aging Fertility and Sterility. 102: e331. DOI: 10.1016/J.Fertnstert.2014.07.1121  0.01
2013 Pyle AM. Coordinating the party: assembly factors and ribogenesis. Molecular Cell. 52: 469-70. PMID 24267447 DOI: 10.1016/J.Molcel.2013.11.007  1
2013 Marcia M, Humphris-Narayanan E, Keating KS, Somarowthu S, Rajashankar K, Pyle AM. Solving nucleic acid structures by molecular replacement: examples from group II intron studies. Acta Crystallographica. Section D, Biological Crystallography. 69: 2174-85. PMID 24189228 DOI: 10.1107/S0907444913013218  1
2013 Ostankovitch M, Pyle AM. Noncoding RNAs: A story of networks and long-distance relationships. Journal of Molecular Biology. 425: 3577-81. PMID 23911549 DOI: 10.1016/J.Jmb.2013.07.032  1
2013 Kohlway A, Luo D, Rawling DC, Ding SC, Pyle AM. Defining the functional determinants for RNA surveillance by RIG-I. Embo Reports. 14: 772-9. PMID 23897087 DOI: 10.1038/Embor.2013.108  1
2013 Nagy V, Pirakitikulr N, Zhou KI, Chillón I, Luo J, Pyle AM. Predicted group II intron lineages E and F comprise catalytically active ribozymes. Rna (New York, N.Y.). 19: 1266-78. PMID 23882113 DOI: 10.1261/Rna.039123.113  1
2013 Marcia M, Somarowthu S, Pyle AM. Now on display: a gallery of group II intron structures at different stages of catalysis. Mobile Dna. 4: 14. PMID 23634971 DOI: 10.1186/1759-8753-4-14  1
2013 Luo D, Kohlway A, Pyle AM. Duplex RNA activated ATPases (DRAs): platforms for RNA sensing, signaling and processing. Rna Biology. 10: 111-20. PMID 23228901 DOI: 10.4161/Rna.22706  1
2012 Marcia M, Pyle AM. Visualizing group II intron catalysis through the stages of splicing. Cell. 151: 497-507. PMID 23101623 DOI: 10.1016/J.Cell.2012.09.033  1
2012 Vela A, Fedorova O, Ding SC, Pyle AM. The thermodynamic basis for viral RNA detection by the RIG-I innate immune sensor. The Journal of Biological Chemistry. 287: 42564-73. PMID 23055530 DOI: 10.1074/Jbc.M112.385146  1
2012 Luo D, Kohlway A, Vela A, Pyle AM. Visualizing the determinants of viral RNA recognition by innate immune sensor RIG-I. Structure (London, England : 1993). 20: 1983-8. PMID 23022350 DOI: 10.1016/J.Str.2012.08.029  1
2012 Keating KS, Pyle AM. RCrane: semi-automated RNA model building. Acta Crystallographica. Section D, Biological Crystallography. 68: 985-95. PMID 22868764 DOI: 10.1107/S0907444912018549  1
2012 Ding SC, Pyle AM. Molecular mechanics of RNA translocases. Methods in Enzymology. 511: 131-47. PMID 22713318 DOI: 10.1016/B978-0-12-396546-2.00006-1  1
2012 Fedorova O, Pyle AM. The brace for a growing scaffold: Mss116 protein promotes RNA folding by stabilizing an early assembly intermediate. Journal of Molecular Biology. 422: 347-65. PMID 22705286 DOI: 10.1016/J.Jmb.2012.05.037  1
2012 Chan RT, Robart AR, Rajashankar KR, Pyle AM, Toor N. Crystal structure of a group II intron in the pre-catalytic state. Nature Structural & Molecular Biology. 19: 555-7. PMID 22484319 DOI: 10.1038/Nsmb.2270  1
2012 Humphris-Narayanan E, Pyle AM. Discrete RNA libraries from pseudo-torsional space. Journal of Molecular Biology. 421: 6-26. PMID 22425640 DOI: 10.1016/J.Jmb.2012.03.002  1
2011 Luo D, Ding SC, Vela A, Kohlway A, Lindenbach BD, Pyle AM. Structural insights into RNA recognition by RIG-I. Cell. 147: 409-22. PMID 22000018 DOI: 10.1016/J.Cell.2011.09.023  1
2011 Butcher SE, Pyle AM. The molecular interactions that stabilize RNA tertiary structure: RNA motifs, patterns, and networks. Accounts of Chemical Research. 44: 1302-11. PMID 21899297 DOI: 10.1021/Ar200098T  1
2011 Pyle AM. RNA helicases and remodeling proteins. Current Opinion in Chemical Biology. 15: 636-42. PMID 21862383 DOI: 10.1016/J.Cbpa.2011.07.019  1
2011 Keating KS, Humphris EL, Pyle AM. A new way to see RNA. Quarterly Reviews of Biophysics. 44: 433-66. PMID 21729350 DOI: 10.1017/S0033583511000059  1
2011 Pyle AM, Shakked Z. The ever-growing complexity of nucleic acids: from small DNA and RNA motifs to large molecular assemblies and machines. Current Opinion in Structural Biology. 21: 293-5. PMID 21565486 DOI: 10.1016/J.Sbi.2011.04.003  1
2011 Cao W, Coman MM, Ding S, Henn A, Middleton ER, Bradley MJ, Rhoades E, Hackney DD, Pyle AM, De La Cruz EM. Mechanism of Mss116 ATPase reveals functional diversity of DEAD-Box proteins. Journal of Molecular Biology. 409: 399-414. PMID 21501623 DOI: 10.1016/J.Jmb.2011.04.004  1
2011 Ding SC, Kohlway AS, Pyle AM. Unmasking the active helicase conformation of nonstructural protein 3 from hepatitis C virus. Journal of Virology. 85: 4343-53. PMID 21325413 DOI: 10.1128/Jvi.02130-10  1
2011 Appleby TC, Anderson R, Fedorova O, Pyle AM, Wang R, Liu X, Brendza KM, Somoza JR. Visualizing ATP-dependent RNA translocation by the NS3 helicase from HCV. Journal of Molecular Biology. 405: 1139-53. PMID 21145896 DOI: 10.1016/J.Jmb.2010.11.034  1
2011 Phan T, Kohlway A, Dimberu P, Pyle AM, Lindenbach BD. The acidic domain of hepatitis C virus NS4A contributes to RNA replication and virus particle assembly. Journal of Virology. 85: 1193-204. PMID 21047963 DOI: 10.1128/Jvi.01889-10  1
2011 Luo D, Pyle AM. Structural basis of double-stranded RNA recognition by RIG-I Acta Crystallographica Section a Foundations of Crystallography. 67: C160-C160. DOI: 10.1107/S0108767311096073  0.01
2010 Karunatilaka KS, Solem A, Pyle AM, Rueda D. Single-molecule analysis of Mss116-mediated group II intron folding. Nature. 467: 935-9. PMID 20944626 DOI: 10.1016/J.Bpj.2009.12.2568  1
2010 Zingler N, Solem A, Pyle AM. Dual roles for the Mss116 cofactor during splicing of the ai5γ group II intron. Nucleic Acids Research. 38: 6602-9. PMID 20554854 DOI: 10.1093/Nar/Gkq530  1
2010 Matranga C, Pyle AM. Double-stranded RNA-dependent ATPase DRH-3: insight into its role in RNAsilencing in Caenorhabditis elegans. The Journal of Biological Chemistry. 285: 25363-71. PMID 20529861 DOI: 10.1074/Jbc.M110.117010  1
2010 Pyle AM. The tertiary structure of group II introns: implications for biological function and evolution. Critical Reviews in Biochemistry and Molecular Biology. 45: 215-32. PMID 20446804 DOI: 10.3109/10409231003796523  1
2010 Keating KS, Pyle AM. Semiautomated model building for RNA crystallography using a directed rotameric approach. Proceedings of the National Academy of Sciences of the United States of America. 107: 8177-82. PMID 20404211 DOI: 10.1073/Pnas.0911888107  1
2010 Fedorova O, Solem A, Pyle AM. Protein-facilitated folding of group II intron ribozymes. Journal of Molecular Biology. 397: 799-813. PMID 20138894 DOI: 10.1016/J.Jmb.2010.02.001  1
2010 Roitzsch M, Fedorova O, Pyle AM. The 2'-OH group at the group II intron terminus acts as a proton shuttle. Nature Chemical Biology. 6: 218-224. PMID 20118939 DOI: 10.1038/Nchembio.312  1
2010 Taylor SD, Solem A, Kawaoka J, Pyle AM. The NPH-II helicase displays efficient DNA x RNA helicase activity and a pronounced purine sequence bias. The Journal of Biological Chemistry. 285: 11692-703. PMID 20110368 DOI: 10.1074/Jbc.M109.088559  1
2010 Toor N, Keating KS, Fedorova O, Rajashankar K, Wang J, Pyle AM. Tertiary architecture of the Oceanobacillus iheyensis group II intron. Rna (New York, N.Y.). 16: 57-69. PMID 19952115 DOI: 10.1261/Rna.1844010  1
2010 Keating KS, Toor N, Perlman PS, Pyle AM. A structural analysis of the group II intron active site and implications for the spliceosome. Rna (New York, N.Y.). 16: 1-9. PMID 19948765 DOI: 10.1261/Rna.1791310  1
2010 Pyle A. Principles of RNA Tertiary Structural Organization Revealed by Group II Intron Crystal Structures Biophysical Journal. 98: 198a. DOI: 10.1016/J.Bpj.2009.12.1052  0.01
2010 PYLE AM, BARTON JK. ChemInform Abstract: Probing Nucleic Acids with Transition Metal Complexes Cheminform. 22: no-no. DOI: 10.1002/chin.199143288  0.04
2010 Pyle AM. Touching RNA: RNA can bind and sense the shapes of other molecules by feeling them with its backbone- and not just its bases. What gives RNA molecules this remarkable versatility? Scientist. 24.  1
2009 Pyle AM. How to drive your helicase in a straight line. Cell. 139: 458-9. PMID 19879832 DOI: 10.1016/J.Cell.2009.10.016  1
2009 Toor N, Keating KS, Pyle AM. Structural insights into RNA splicing. Current Opinion in Structural Biology. 19: 260-6. PMID 19443210 DOI: 10.1016/J.Sbi.2009.04.002  1
2009 Roitzsch M, Pyle AM. The linear form of a group II intron catalyzes efficient autocatalytic reverse splicing, establishing a potential for mobility. Rna (New York, N.Y.). 15: 473-82. PMID 19168748 DOI: 10.1261/Rna.1392009  1
2009 Beran RK, Lindenbach BD, Pyle AM. The NS4A protein of hepatitis C virus promotes RNA-coupled ATP hydrolysis by the NS3 helicase. Journal of Virology. 83: 3268-75. PMID 19153239 DOI: 10.1128/Jvi.01849-08  1
2009 Serebrov V, Beran RK, Pyle AM. Establishing a mechanistic basis for the large kinetic steps of the NS3 helicase. The Journal of Biological Chemistry. 284: 2512-21. PMID 19010782 DOI: 10.1074/Jbc.M805460200  1
2008 Toor N, Rajashankar K, Keating KS, Pyle AM. Structural basis for exon recognition by a group II intron. Nature Structural & Molecular Biology. 15: 1221-2. PMID 18953333 DOI: 10.1038/Nsmb.1509  1
2008 Zingler N, Solem A, Pyle AM. Protein-facilitated ribozyme folding and catalysis. Nucleic Acids Symposium Series (2004). 67-8. PMID 18776256 DOI: 10.1093/nass/nrn034  1
2008 Keating KS, Toor N, Pyle AM. The GANC tetraloop: a novel motif in the group IIC intron structure. Journal of Molecular Biology. 383: 475-81. PMID 18773908 DOI: 10.1016/J.Jmb.2008.08.043  1
2008 Beran RK, Pyle AM. Hepatitis C viral NS3-4A protease activity is enhanced by the NS3 helicase. The Journal of Biological Chemistry. 283: 29929-37. PMID 18723512 DOI: 10.1074/Jbc.M804065200  1
2008 Pyle AM. Translocation and unwinding mechanisms of RNA and DNA helicases. Annual Review of Biophysics. 37: 317-36. PMID 18573084 DOI: 10.1146/Annurev.Biophys.37.032807.125908  1
2008 Fedorova O, Pyle AM. A conserved element that stabilizes the group II intron active site. Rna (New York, N.Y.). 14: 1048-56. PMID 18441048 DOI: 10.1261/Rna.942308  1
2008 Toor N, Keating KS, Taylor SD, Pyle AM. Crystal structure of a self-spliced group II intron. Science (New York, N.Y.). 320: 77-82. PMID 18388288 DOI: 10.1126/Science.1153803  1
2008 Richardson JS, Schneider B, Murray LW, Kapral GJ, Immormino RM, Headd JJ, Richardson DC, Ham D, Hershkovits E, Williams LD, Keating KS, Pyle AM, Micallef D, Westbrook J, Berman HM, et al. RNA backbone: consensus all-angle conformers and modular string nomenclature (an RNA Ontology Consortium contribution). Rna (New York, N.Y.). 14: 465-81. PMID 18192612 DOI: 10.1261/Rna.657708  1
2008 de Lencastre A, Pyle AM. Three essential and conserved regions of the group II intron are proximal to the 5'-splice site. Rna (New York, N.Y.). 14: 11-24. PMID 18039742 DOI: 10.1261/Rna.774008  1
2008 Waldsich C, Pyle AM. A kinetic intermediate that regulates proper folding of a group II intron RNA. Journal of Molecular Biology. 375: 572-80. PMID 18022197 DOI: 10.1016/J.Jmb.2007.10.052  1
2008 Fedorova O, Boudvillain M, Kawaoka J, Pyle AM. Nucleotide Analog Interference Mapping and Suppression: Specific Applications in Studies of RNA Tertiary Structure, Dynamic Helicase Mechanism and RNA-Protein Interactions Handbook of Rna Biochemistry. 259-293. DOI: 10.1002/9783527619504.ch17  1
2008 Beran RKF, Serebrov V, Pyle AM. The serine protease domain of hepatitis C viral NS3 activates RNA helicase activity by promoting the binding of RNA substrate (Journal of Biological Chemistry (2007) 282, (34913-34920)) Journal of Biological Chemistry. 283: 5971.  1
2007 Beran RK, Serebrov V, Pyle AM. The serine protease domain of hepatitis C viral NS3 activates RNA helicase activity by promoting the binding of RNA substrate. The Journal of Biological Chemistry. 282: 34913-20. PMID 17921146 DOI: 10.1074/Jbc.M707165200  1
2007 Wagner GP, Pyle AM. Tinkering with transcription factor proteins: the role of transcription factor adaptation in developmental evolution. Novartis Foundation Symposium. 284: 116-25; discussion 1. PMID 17710850 DOI: 10.1002/9780470319390.Ch8  1
2007 Wadley LM, Keating KS, Duarte CM, Pyle AM. Evaluating and learning from RNA pseudotorsional space: quantitative validation of a reduced representation for RNA structure. Journal of Molecular Biology. 372: 942-57. PMID 17707400 DOI: 10.1016/J.Jmb.2007.06.058  1
2007 Myong S, Bruno MM, Pyle AM, Ha T. Spring-loaded mechanism of DNA unwinding by hepatitis C virus NS3 helicase. Science (New York, N.Y.). 317: 513-6. PMID 17656723 DOI: 10.1126/Science.1144130  1
2007 Lindenbach BD, Prágai BM, Montserret R, Beran RK, Pyle AM, Penin F, Rice CM. The C terminus of hepatitis C virus NS4A encodes an electrostatic switch that regulates NS5A hyperphosphorylation and viral replication. Journal of Virology. 81: 8905-18. PMID 17581983 DOI: 10.1128/Jvi.00937-07  1
2007 Pyle AM, Fedorova O, Waldsich C. Folding of group II introns: a model system for large, multidomain RNAs? Trends in Biochemical Sciences. 32: 138-45. PMID 17289393 DOI: 10.1016/J.Tibs.2007.01.005  1
2007 Tang CL, Alexov E, Pyle AM, Honig B. Calculation of pKas in RNA: on the structural origins and functional roles of protonated nucleotides. Journal of Molecular Biology. 366: 1475-96. PMID 17223134 DOI: 10.1016/J.Jmb.2006.12.001  1
2007 Sigel RK, Pyle AM. Alternative roles for metal ions in enzyme catalysis and the implications for ribozyme chemistry. Chemical Reviews. 107: 97-113. PMID 17212472 DOI: 10.1021/Cr0502605  1
2007 Fedorova O, Waldsich C, Pyle AM. Group II intron folding under near-physiological conditions: collapsing to the near-native state. Journal of Molecular Biology. 366: 1099-114. PMID 17196976 DOI: 10.1016/J.Jmb.2006.12.003  1
2007 Waldsich C, Pyle AM. A folding control element for tertiary collapse of a group II intron ribozyme. Nature Structural & Molecular Biology. 14: 37-44. PMID 17143279 DOI: 10.1038/Nsmb1181  1
2007 Pyle AM. Group II intron ribozymes: RNA machines that shape eukaryotic evolution The Faseb Journal. 21. DOI: 10.1096/fasebj.21.5.a41-b  0.01
2007 Pyle AM, Barton JK. Probing Nucleic Acids with Transition Metal Complexes Progress in Inorganic Chemistry. 38: 413-475. DOI: 10.1002/9780470166390.Ch7  1
2007 Toor N, Keating K, Taylor S, Pyle A. Crystal structure of self-spliced group II intron Chemtracts. 20: 437-439.  1
2006 Solem A, Zingler N, Pyle AM. A DEAD protein that activates intron self-splicing without unwinding RNA. Molecular Cell. 24: 611-7. PMID 17188036 DOI: 10.1016/J.Molcel.2006.10.032  1
2006 Hamill S, Pyle AM. The receptor for branch-site docking within a group II intron active site. Molecular Cell. 23: 831-40. PMID 16973435 DOI: 10.1016/J.Molcel.2006.07.017  1
2006 Beran RK, Bruno MM, Bowers HA, Jankowsky E, Pyle AM. Robust translocation along a molecular monorail: the NS3 helicase from hepatitis C virus traverses unusually large disruptions in its track. Journal of Molecular Biology. 358: 974-82. PMID 16569413 DOI: 10.1016/J.Jmb.2006.02.078  1
2006 Dumont S, Cheng W, Serebrov V, Beran RK, Tinoco I, Pyle AM, Bustamante C. RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP. Nature. 439: 105-8. PMID 16397502 DOI: 10.1038/Nature04331  1
2006 Pyle AM, Lambowitz AM. 17 Group II Introns: Ribozymes That Splice RNA and Invade DNA Cold Spring Harbor Monograph Archive. 43: 469-505. DOI: 10.1101/087969739.43.469  1
2006 Pyle AM, Widom J. Nucleic acids Current Opinion in Structural Biology. 16: 267-269. DOI: 10.1016/J.Sbi.2006.05.013  1
2005 Su LJ, Waldsich C, Pyle AM. An obligate intermediate along the slow folding pathway of a group II intron ribozyme. Nucleic Acids Research. 33: 6674-87. PMID 16314300 DOI: 10.1093/Nar/Gki973  1
2005 Fedorova O, Pyle AM. Linking the group II intron catalytic domains: tertiary contacts and structural features of domain 3. The Embo Journal. 24: 3906-16. PMID 16252007 DOI: 10.1038/Sj.Emboj.7600852  1
2005 Pyle AM. Capping by branching: a new ribozyme makes tiny lariats. Science (New York, N.Y.). 309: 1530-1. PMID 16141065 DOI: 10.1126/Science.1117957  1
2005 de Lencastre A, Hamill S, Pyle AM. A single active-site region for a group II intron. Nature Structural & Molecular Biology. 12: 626-7. PMID 15980867 DOI: 10.1038/Nsmb957  1
2005 Kawaoka J, Pyle AM. Choosing between DNA and RNA: the polymer specificity of RNA helicase NPH-II. Nucleic Acids Research. 33: 644-9. PMID 15681616 DOI: 10.1093/Nar/Gki208  1
2005 Pang PS, Jankowsky E, Wadley LM, Pyle AM. Prediction of functional tertiary interactions and intermolecular interfaces from primary sequence data. Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution. 304: 50-63. PMID 15595717 DOI: 10.1002/Jez.B.21024  1
2004 Wadley LM, Pyle AM. The identification of novel RNA structural motifs using COMPADRES: an automated approach to structural discovery. Nucleic Acids Research. 32: 6650-9. PMID 15608296 DOI: 10.1093/Nar/Gkh1002  1
2004 Pyle AM. DNA repair: big engine finds small breaks. Nature. 432: 157-8. PMID 15538349 DOI: 10.1038/432157A  1
2004 Serebrov V, Pyle AM. Periodic cycles of RNA unwinding and pausing by hepatitis C virus NS3 helicase. Nature. 430: 476-80. PMID 15269774 DOI: 10.1038/Nature02704  1
2004 Kawaoka J, Jankowsky E, Pyle AM. Backbone tracking by the SF2 helicase NPH-II. Nature Structural & Molecular Biology. 11: 526-30. PMID 15146171 DOI: 10.1038/Nsmb771  1
2004 Sigel RK, Sashital DG, Abramovitz DL, Palmer AG, Butcher SE, Pyle AM. Solution structure of domain 5 of a group II intron ribozyme reveals a new RNA motif. Nature Structural & Molecular Biology. 11: 187-92. PMID 14745440 DOI: 10.1038/Nsmb717  1
2004 Sigel R, Sashital D, Abramowitz D, Palmer A, Butcher S, Pyle AM. Chemical shifts assignments of domain 5 of the ai5gamma group II intron Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr5962  0.01
2003 Su LJ, Brenowitz M, Pyle AM. An alternative route for the folding of large RNAs: apparent two-state folding by a group II intron ribozyme. Journal of Molecular Biology. 334: 639-52. PMID 14636593 DOI: 10.1016/J.Jmb.2003.09.071  1
2003 Duarte CM, Wadley LM, Pyle AM. RNA structure comparison, motif search and discovery using a reduced representation of RNA conformational space. Nucleic Acids Research. 31: 4755-61. PMID 12907716 DOI: 10.1093/Nar/Gkg682  1
2003 Fedorova O, Mitros T, Pyle AM. Domains 2 and 3 interact to form critical elements of the group II intron active site. Journal of Molecular Biology. 330: 197-209. PMID 12823961 DOI: 10.1016/S0022-2836(03)00594-1  1
2003 Sigel RK, Pyle AM. Lanthanide ions as probes for metal ions in the structure and catalytic mechanism of ribozymes. Metal Ions in Biological Systems. 40: 477-512. PMID 12723158  1
2003 Aizawa Y, Xiang Q, Lambowitz AM, Pyle AM. The pathway for DNA recognition and RNA integration by a group II intron retrotransposon. Molecular Cell. 11: 795-805. PMID 12667460 DOI: 10.1016/S1097-2765(03)00069-8  1
2003 Adamidi C, Fedorova O, Pyle AM. A group II intron inserted into a bacterial heat-shock operon shows autocatalytic activity and unusual thermostability. Biochemistry. 42: 3409-18. PMID 12653544 DOI: 10.1021/Bi027330B  1
2002 Fedorova O, Su LJ, Pyle AM. Group II introns: highly specific endonucleases with modular structures and diverse catalytic functions. Methods (San Diego, Calif.). 28: 323-35. PMID 12431436 DOI: 10.1016/S1046-2023(02)00239-6  1
2002 Pyle AM. Metal ions in the structure and function of RNA. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 7: 679-90. PMID 12203005 DOI: 10.1007/S00775-002-0387-6  1
2002 Pang PS, Jankowsky E, Planet PJ, Pyle AM. The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding. The Embo Journal. 21: 1168-76. PMID 11867545 DOI: 10.1093/Emboj/21.5.1168  1
2002 Kang DC, Gopalkrishnan RV, Wu Q, Jankowsky E, Pyle AM, Fisher PB. mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties. Proceedings of the National Academy of Sciences of the United States of America. 99: 637-42. PMID 11805321 DOI: 10.1073/Pnas.022637199  1
2002 Swisher JF, Su LJ, Brenowitz M, Anderson VE, Pyle AM. Productive folding to the native state by a group II intron ribozyme. Journal of Molecular Biology. 315: 297-310. PMID 11786013 DOI: 10.1006/Jmbi.2001.5233  1
2001 Aizawa Y, Xiang Q, Pyle AM. Kinetic dissection of the multistep process in L1.ltrB intron mobility. Nucleic Acids Research. Supplement (2001). 249-50. PMID 12836358  1
2001 Chu VT, Adamidi C, Liu Q, Perlman PS, Pyle AM. Control of branch-site choice by a group II intron. The Embo Journal. 20: 6866-76. PMID 11726522 DOI: 10.1093/Emboj/20.23.6866  1
2001 Swisher J, Duarte CM, Su LJ, Pyle AM. Visualizing the solvent-inaccessible core of a group II intron ribozyme. The Embo Journal. 20: 2051-61. PMID 11296237 DOI: 10.1093/Emboj/20.8.2051  1
2001 Su LJ, Qin PZ, Michels WJ, Pyle AM. Guiding ribozyme cleavage through motif recognition: the mechanism of cleavage site selection by a group ii intron ribozyme. Journal of Molecular Biology. 306: 655-68. PMID 11243778 DOI: 10.1006/Jmbi.2000.4323  1
2001 Jankowsky E, Gross CH, Shuman S, Pyle AM. Active disruption of an RNA-protein interaction by a DExH/D RNA helicase. Science (New York, N.Y.). 291: 121-5. PMID 11141562 DOI: 10.1126/Science.291.5501.121  1
2000 Sigel RK, Vaidya A, Pyle AM. Metal ion binding sites in a group II intron core. Nature Structural Biology. 7: 1111-6. PMID 11101891 DOI: 10.1038/81958  1
2000 Boudvillain M, de Lencastre A, Pyle AM. A tertiary interaction that links active-site domains to the 5' splice site of a group II intron. Nature. 406: 315-8. PMID 10917534 DOI: 10.1038/35018589  1
2000 Pyle AM, Chu VT, Jankowsky E, Boudvillain M. Using DNAzymes to cut, process, and map RNA molecules for structural studies or modification. Methods in Enzymology. 317: 140-6. PMID 10829278 DOI: 10.1016/S0076-6879(00)17012-0  1
2000 Pyle AM. New tricks from an itinerant intron. Nature Structural Biology. 7: 352-4. PMID 10802726 DOI: 10.1038/75111  1
2000 Jankowsky E, Gross CH, Shuman S, Pyle AM. The DExH protein NPH-II is a processive and directional motor for unwinding RNA. Nature. 403: 447-51. PMID 10667799 DOI: 10.1038/35000239  1
1999 Chin K, Sharp KA, Honig B, Pyle AM. Calculating the electrostatic properties of RNA provides new insights into molecular interactions and function. Nature Structural Biology. 6: 1055-61. PMID 10542099 DOI: 10.1038/14940  1
1999 Qin PZ, Pyle AM. Antagonistic substrate binding by a group II intron ribozyme. Journal of Molecular Biology. 291: 15-27. PMID 10438603 DOI: 10.1006/Jmbi.1999.2922  1
1999 Qin PZ, Pyle AM. Site-specific labeling of RNA with fluorophores and other structural probes Methods: a Companion to Methods in Enzymology. 18: 60-70. PMID 10208817 DOI: 10.1006/Meth.1999.0757  1
1998 Duarte CM, Pyle AM. Stepping through an RNA structure: A novel approach to conformational analysis Journal of Molecular Biology. 284: 1465-1478. PMID 9878364 DOI: 10.1006/Jmbi.1998.2233  1
1998 Konforti BB, Liu Q, Pyle AM. A map of the binding site for catalytic domain 5 in the core of a group II intron ribozyme Embo Journal. 17: 7105-7117. PMID 9843514 DOI: 10.1093/Emboj/17.23.7105  1
1998 Boudvillain M, Pyle AM. Defining functional groups, core structural features and inter-domain tertiary contacts essential for group II intron self-splicing: A NAIM analysis Embo Journal. 17: 7091-7104. PMID 9843513 DOI: 10.1093/Emboj/17.23.7091  1
1998 Swisher JF, Rand E, Cedar H, Marie Pyle A. Analysis of putative RNase sensitivity and protease insensitivity of demethylation activity in extracts from rat myoblasts. Nucleic Acids Research. 26: 5573-80. PMID 9837985 DOI: 10.1093/Nar/26.24.5573  1
1998 Chu VT, Liu Q, Podar M, Perlman PS, Pyle AM. More than one way to splice an RNA: branching without a bulge and splicing without branching in group II introns. Rna (New York, N.Y.). 4: 1186-202. PMID 9769094 DOI: 10.1017/S1355838298980724  1
1998 Qin PZ, Pyle AM. The architectural organization and mechanistic function of group II intron structural elements Current Opinion in Structural Biology. 8: 301-308. PMID 9666325 DOI: 10.1016/S0959-440X(98)80062-6  1
1998 Konforti BB, Abramovitz DL, Duarte CM, Karpeisky A, Beigelman L, Pyle AM. Ribozyme catalysis from the major groove of group II intron domain 5 Molecular Cell. 1: 433-441. PMID 9660927 DOI: 10.1016/S1097-2765(00)80043-X  1
1998 Wagner JDO, Jankowsky E, Company M, Pyle AM, Abelson JN. The DEAH-box protein PRP22 is an ATPase that mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes Embo Journal. 17: 2926-2937. PMID 9582286 DOI: 10.1093/Emboj/17.10.2926  1
1998 Xiang Q, Qin PZ, Michels WJ, Freeland K, Pyle AM. Sequence specificity of a group II intron ribozyme: Multiple mechanisms for promoting unusually high discrimination against mismatched targets Biochemistry. 37: 3839-3849. PMID 9521704 DOI: 10.1021/Bi972661N  1
1998 Podar M, Chu VT, Pyle AM, Perlman PS. Group II intron splicing in vivo by first-step hydrolysis. Nature. 391: 915-8. PMID 9495347 DOI: 10.1038/36142  1
1997 Qin PZ, Pyle AM. Stopped-flow fluorescence spectroscopy of a group II intron ribozyme reveals that domain I is an independent folding unit with a requirement for specific Mg2+ ions in the tertiary structure Biochemistry. 36: 4718-4730. PMID 9125492 DOI: 10.1021/Bi962665C  1
1997 Liu Q, Green JB, Khodadadi A, Haeberli P, Beigelman L, Pyle AM. Branch-site selection in a group II intron mediated by active recognition of the adenine amino group and steric exclusion of non-adenine functionalities. Journal of Molecular Biology. 267: 163-71. PMID 9096215 DOI: 10.1006/Jmbi.1996.0845  1
1997 Abramovitz DL, Pyle AM. Remarkable morphologlical variability of a common RNA folding motif: The GNRA tetraloop-receptor interaction Journal of Molecular Biology. 266: 493-506. PMID 9067606 DOI: 10.1006/Jmbi.1996.0810  1
1997 Pyle AM, Konforti BB, Abramovitz DL, Liu Q. Rna folding and catalysis by group ii intron ribozymes Faseb Journal. 11: A1446. DOI: 10.1016/0959-440X(95)80091-3  1
1997 Quarte CM, Pyle AM. A pseudotorsional descriptor of rna conformation can quantify secondary Structure Faseb Journal. 11: A1407.  1
1996 Pyle AM. Inside an intron invasion Nature. 381: 280-281. PMID 8692263 DOI: 10.1038/381280A0  1
1996 Pyle AM. Role of metal ions in ribozymes Metal Ions in Biological Systems. 32: 479-520. PMID 8640529  1
1996 Daniels DL, Michels WJ, Pyle AM. Two competing pathways for self-splicing by group II introns: A quantitative analysis of in vitro reaction rates and products Journal of Molecular Biology. 256: 31-49. PMID 8609612 DOI: 10.1006/Jmbi.1996.0066  1
1996 Abramovitz DL, Friedman RA, Pyle AM. Catalytic Role of 2′-Hydroxyl Groups Within a Group II Intron Active Site Science. 271: 1410-1413. PMID 8596912 DOI: 10.1126/Science.271.5254.1410  1
1996 Abramovitz DL, Friedman RA, Pyle AM. Catalytic pole of 2'-hydroxyl groups within a group II intron active site Science. 271: 1410-1413.  1
1995 Griffiin EA, Qin Z, Michels WJ, Pyle AM. Group II intron ribozymes that cleave DNA and RNA linkages with similar efficiency, and lack contacts with substrate 2′-hydroxyl groups Chemistry and Biology. 2: 761-770. PMID 9383483 DOI: 10.1016/1074-5521(95)90104-3  1
1995 Michels WJ, Pyle AM. Conversion of a group II intron into a new multiple-turnover ribozyme that selectively cleaves oligonucleotides: Elucidation of reaction mechanism and structure/function relationships Biochemistry. 34: 2965-2977. PMID 7893710 DOI: 10.1021/Bi00009A028  1
1995 Chin K, Pyle AM. Branch-point attack in group II introns is a highly reversible transesterification, providing a potential proofreading mechanism for 5′-splice site selection Rna. 1: 391-406. PMID 7493317  1
1994 Pyle AM, Green JB. Building a kinetic framework for group II intron ribozyme activity: Quantitation of interdomain binding and reaction rate Biochemistry. 33: 2716-2725. PMID 8117737 DOI: 10.1021/Bi00175A047  1
1994 Pyle AM, Moran S, Strobel SA, Chapman T, Turner DH, Cech TR. Replacement of the conserved G.U with a G-C pair at the cleavage site of the Tetrahymena ribozyme decreases binding, reactivity, and fidelity. Biochemistry. 33: 13856-63. PMID 7947794 DOI: 10.1021/Bi00250A040  1
1994 Pyle AM. Replacement of the conserved g·u with a g·c pair at the cleavage site of the tetrahymena ribozyme decreases binding, reactivity, and fidelity Biochemistry. 33: 13856-13863.  1
1993 Pyle AM. Ribozymes: A distinct class of metalloenzymes Science. 261: 709-714. PMID 7688142 DOI: 10.1126/Science.7688142  1
1992 Cech TR, Herschlag D, Piccirilli JA, Pyle AM. RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization. The Journal of Biological Chemistry. 267: 17479-82. PMID 1381347  1
1992 Pyle AM, Murphy FL, Cech TR. RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme. Nature. 358: 123-8. PMID 1377367 DOI: 10.1038/358123A0  1
1992 Sitlani A, Long EC, Pyle AM, Barton JK. DNA photocleavage by phenanthrenequinone diimine complexes of rhodium(III): Shape-selective recognition and reaction Journal of the American Chemical Society. 114: 2303-2312. DOI: 10.1021/Ja00033A003  1
1991 Pyle AM, Cech TR. Ribozyme recognition of RNA by tertiary interactions with specific ribose 2'-OH groups. Nature. 350: 628-31. PMID 1708111 DOI: 10.1038/350628A0  1
1990 Pyle AM, McSwiggen JA, Cech TR. Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena. Proceedings of the National Academy of Sciences of the United States of America. 87: 8187-91. PMID 2236030 DOI: 10.1073/Pnas.87.21.8187  1
1990 Pyle AM, Morii T, Barton JK. Probing microstructures in double-helical DNA with chiral metal complexes: Recognition of changes in base-pair propeller twisting in solution Journal of the American Chemical Society. 112: 9432-9434. DOI: 10.1021/Ja00181A077  1
1990 Pyle AM, Chiang MY, Barton JK. Synthesis and characterization of physical, electronic, and photochemical aspects of 9,10-phenanthrenequinone diimine complexes of ruthenium(II) and rhodium(III) Inorganic Chemistry. 29: 4487-4495. DOI: 10.1021/Ic00347A031  1
1989 Uchida K, Pyle AM, Morii T, Barton JK. High resolution footprinting of EcoRI and distamycin with Rh(phi)2(bpy)3+, a new photofootprinting reagent. Nucleic Acids Research. 17: 10259-79. PMID 2602152 DOI: 10.1093/Nar/17.24.10259  1
1989 Pyle AM, Long EC, Barton JK. Shape-selective targeting of DNA by (phenanthrenequinone diimine)rhodium(III) photocleaving agents Journal of the American Chemical Society. 111: 4520-4522. DOI: 10.1021/Ja00194A070  1
1989 Pyle AM, Rehmann JP, Meshoyrer R, Kumar CV, Turro NJ, Barton JK. Mixed-ligand complexes of ruthenium(II): Factors governing binding to DNA Journal of the American Chemical Society. 111: 3051-3058. DOI: 10.1021/Ja00190A046  1
1989 Uchida K, Pyle A, Morii T, Barton J. Photofootprinting of EcoRi endonuclease and distamycin by a phenanthrenequinonediimine rhodium(III) complex Journal of Inorganic Biochemistry. 36: 276. DOI: 10.1016/0162-0134(89)84382-X  0.01
1987 Pyle AM, Barton JK. Synthesis and spectroscopic characterization of the purple tris(phenanthrenequinone diimine)ruthenium(II) ion Inorganic Chemistry. 26: 3820-3823. DOI: 10.1021/Ic00269A041  0.12
1987 Pyle AM, Barton JK. Synthesis and spectroscopic characterization of the purple tris(phenanthrenequinone diimine)ruthenium(II) ion Inorganic Chemistry. 26: 3820-3823.  1
1986 Pyle AM, Jens KJ. H/D exchange in methane and other saturated hydrocarbons catalyzed by a supported zirconium complex Journal of Molecular Catalysis. 38: 337-339. DOI: 10.1016/0304-5102(86)85042-8  1
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