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Jon Lorsch - Publications

Affiliations: 
Johns Hopkins University School of Medicine, Baltimore, MD, United States 
Area:
Protein synthesis, regulation of translation
Website:
http://biophysics.med.jhmi.edu/BIOPHYS/lorsch.html

103 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Collins FS, Adams AB, Aklin C, Archer TK, Bernard MA, Boone E, Burklow J, Evans MK, Jackson S, Johnson AC, Lorsch J, Lowden MR, Nápoles AM, Ordóñez AE, Rivers R, et al. Affirming NIH's commitment to addressing structural racism in the biomedical research enterprise. Cell. 184: 3075-3079. PMID 34115967 DOI: 10.1016/j.cell.2021.05.014  1
2020 Gulay S, Gupta N, Lorsch JR, Hinnebusch AG. Distinct interactions of eIF4A and eIF4E with RNA helicase Ded1 stimulate translation in vivo. Elife. 9. PMID 32469309 DOI: 10.7554/Elife.58243  1
2020 Zhou F, Zhang H, Kulkarni S, Lorsch JR, Hinnebusch AG. eIF1 discriminates against suboptimal initiation sites to prevent excessive uORF translation genome-wide. Rna (New York, N.Y.). PMID 31915290 DOI: 10.1261/Rna.073536.119  1
2019 Kulkarni SD, Zhou F, Sen ND, Zhang H, Hinnebusch AG, Lorsch JR. Temperature-dependent regulation of upstream open reading frame translation in S. cerevisiae. Bmc Biology. 17: 101. PMID 31810458 DOI: 10.1186/S12915-019-0718-5  1
2019 Sen ND, Gupta N, K Archer S, Preiss T, Lorsch JR, Hinnebusch AG. Functional interplay between DEAD-box RNA helicases Ded1 and Dbp1 in preinitiation complex attachment and scanning on structured mRNAs in vivo. Nucleic Acids Research. PMID 31299079 DOI: 10.1093/Nar/Gkz595  1
2018 Llácer JL, Hussain T, Saini AK, Nanda JD, Kaur S, Gordiyenko Y, Kumar R, Hinnebusch AG, Lorsch JR, Ramakrishnan V. Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition. Elife. 7. PMID 30475211 DOI: 10.2210/Pdb6Fyx/Pdb  1
2018 Gupta N, Lorsch JR, Hinnebusch AG. Yeast Ded1 promotes 48S translation pre-initiation complex assembly in an mRNA-specific and eIF4F-dependent manner. Elife. 7. PMID 30281017 DOI: 10.7554/Elife.38892  1
2017 Martin-Marcos P, Zhou F, Karunasiri C, Zhang F, Dong J, Nanda J, Sen N, Tamame M, Zeschnigk M, Lorsch JR, Hinnebusch AG. eIF1A residues implicated in cancer stabilize translation preinitiation complexes and favor suboptimal initiation sites in yeast. Elife. 6. PMID 29206102 DOI: 10.7554/Elife.31250  1
2017 Yourik P, Aitken CE, Zhou F, Gupta N, Hinnebusch AG, Lorsch JR. Yeast eIF4A enhances recruitment of mRNAs regardless of their structural complexity. Elife. 6. PMID 29192585 DOI: 10.7554/Elife.31476  1
2017 Dong J, Aitken CE, Thakur A, Shin BS, Lorsch JR, Hinnebusch AG. Rps3/uS3 promotes mRNA binding at the 40S ribosome entry channel and stabilizes preinitiation complexes at start codons. Proceedings of the National Academy of Sciences of the United States of America. PMID 28223523 DOI: 10.1073/Pnas.1620569114  1
2016 Munoz AM, Yourik P, Rajagopal V, Nanda JS, Lorsch JR, Walker SE. Active Yeast Ribosome Preparation Using Monolithic Anion Exchange Chromatography. Rna Biology. 0. PMID 27981882 DOI: 10.1080/15476286.2016.1270004  1
2016 Aitken CE, Beznosková P, Vlčkova V, Chiu WL, Zhou F, Valášek LS, Hinnebusch AG, Lorsch JR. Eukaryotic translation initiation factor 3 plays distinct roles at the mRNA entry and exit channels of the ribosomal preinitiation complex. Elife. 5. PMID 27782884 DOI: 10.7554/Elife.20934  1
2016 Collins FS, Anderson JM, Austin CP, Battey JF, Birnbaum LS, Briggs JP, Clayton JA, Cuthbert B, Eisinger RW, Fauci AS, Gallin JI, Gibbons GH, Glass RI, Gottesman MM, Gray PA, ... ... Lorsch JR, et al. Basic science: Bedrock of progress. Science (New York, N.Y.). 351: 1405. PMID 27013720 DOI: 10.1126/Science.351.6280.1405-A  1
2015 Bourne PE, Lorsch JR, Green ED. Perspective: Sustaining the big-data ecosystem. Nature. 527: S16-7. PMID 26536219 DOI: 10.1038/527S16A  1
2015 Llácer JL, Hussain T, Marler L, Aitken CE, Thakur A, Lorsch JR, Hinnebusch AG, Ramakrishnan V. Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex. Molecular Cell. 59: 399-412. PMID 26212456 DOI: 10.1016/J.Molcel.2015.06.033  1
2015 Lorsch JR. Preface. Methods in Enzymology. 559: xi. PMID 26096508 DOI: 10.1016/S0076-6879(15)00379-1  1
2015 Mitchell SF, Lorsch JR. Protein Affinity Purification using Intein/Chitin Binding Protein Tags. Methods in Enzymology. 559: 111-25. PMID 26096506 DOI: 10.1016/bs.mie.2014.11.002  1
2015 Saini AK, Nanda JS, Martin-Marcos P, Dong J, Zhang F, Bhardwaj M, Lorsch JR, Hinnebusch AG. Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating Pi release and conformational transitions of the preinitiation complex. Nucleic Acids Research. 43: 5673-4. PMID 25990728 DOI: 10.1093/Nar/Gkv510  1
2015 Lorsch JR. Maximizing the return on taxpayers' investments in fundamental biomedical research. Molecular Biology of the Cell. 26: 1578-82. PMID 25926703 DOI: 10.1091/mbc.E14-06-1163  1
2015 Llácer JL, Hussain T, Marler L, Aitken CE, Thakur A, Lorsch JR, Hinnebusch AG, Ramakrishnan V. Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex Molecular Cell. DOI: 10.1016/j.molcel.2015.06.033  1
2014 Lorsch JR, Collins FS, Lippincott-Schwartz J. Cell Biology. Fixing problems with cell lines. Science (New York, N.Y.). 346: 1452-3. PMID 25525228 DOI: 10.1126/Science.1259110  1
2014 Hussain T, Llácer JL, Fernández IS, Munoz A, Martin-Marcos P, Savva CG, Lorsch JR, Hinnebusch AG, Ramakrishnan V. Structural changes enable start codon recognition by the eukaryotic translation initiation complex. Cell. 159: 597-607. PMID 25417110 DOI: 10.1016/J.Cell.2014.10.001  1
2014 Lorsch JR, Barrett K, Pollock D, Barman S. APS leadership meets with NIGMS. The Physiologist. 57: 157, 191-2. PMID 25118455  1
2014 Saini AK, Nanda JS, Martin-Marcos P, Dong J, Zhang F, Bhardwaj M, Lorsch JR, Hinnebusch AG. Eukaryotic translation initiation factor eIF5 promotes the accuracy of start codon recognition by regulating Pi release and conformational transitions of the preinitiation complex. Nucleic Acids Research. 42: 9623-40. PMID 25114053 DOI: 10.1093/Nar/Gku653  1
2014 Kolitz S, Lorsch JR. Protein filter binding. Methods in Enzymology. 541: 197-205. PMID 24674073 DOI: 10.1016/B978-0-12-420119-4.00016-1  1
2014 Mitchell SF, Lorsch JR. Standard in vitro assays for protein-nucleic acid interactions--gel shift assays for RNA and DNA binding. Methods in Enzymology. 541: 179-96. PMID 24674072 DOI: 10.1016/B978-0-12-420119-4.00015-X  1
2014 Dong J, Munoz A, Kolitz SE, Saini AK, Chiu WL, Rahman H, Lorsch JR, Hinnebusch AG. Conserved residues in yeast initiator tRNA calibrate initiation accuracy by regulating preinitiation complex stability at the start codon. Genes & Development. 28: 502-20. PMID 24589778 DOI: 10.1101/Gad.236547.113  1
2014 Lorsch J. Methods in Enzymology. Laboratory methods in enzymology: protein part B. Preface. Methods in Enzymology. 539: xv. PMID 24581446 DOI: 10.1016/B978-0-12-420120-0.09989-8  1
2014 Lorsch J. Methods in Enzymology. Laboratory methods in enzymology: protein part A. Preface. Methods in Enzymology. 536: xv. PMID 24423276 DOI: 10.1016/B978-0-12-420070-8.09988-8  1
2014 Mitchell SF, Lorsch JR. Protein derivitization-expressed protein ligation. Methods in Enzymology. 536: 95-108. PMID 24423270 DOI: 10.1016/B978-0-12-420070-8.00009-X  1
2014 Nanda JS, Lorsch JR. Labeling a protein with fluorophores using NHS ester derivitization. Methods in Enzymology. 536: 87-94. PMID 24423269 DOI: 10.1016/B978-0-12-420070-8.00008-8  1
2014 Nanda JS, Lorsch JR. Labeling of a protein with fluorophores using maleimide derivitization. Methods in Enzymology. 536: 79-86. PMID 24423268 DOI: 10.1016/B978-0-12-420070-8.00007-6  1
2014 Lorsch JR. Practical steady-state enzyme kinetics. Methods in Enzymology. 536: 3-15. PMID 24423262 DOI: 10.1016/B978-0-12-420070-8.00001-5  1
2014 Martin-Marcos P, Nanda JS, Luna RE, Zhang F, Saini AK, Cherkasova VA, Wagner G, Lorsch JR, Hinnebusch AG. Enhanced eIF1 binding to the 40S ribosome impedes conformational rearrangements of the preinitiation complex and elevates initiation accuracy. Rna (New York, N.Y.). 20: 150-67. PMID 24335188 DOI: 10.1261/Rna.042069.113  1
2014 Zhou F, Walker SE, Mitchell SF, Lorsch JR, Hinnebusch AG. Identification and characterization of functionally critical, conserved motifs in the internal repeats and N-terminal domain of yeast translation initiation factor 4B (yeIF4B). The Journal of Biological Chemistry. 289: 1704-22. PMID 24285537 DOI: 10.1074/Jbc.M113.529370  1
2013 Fernández IS, Bai XC, Hussain T, Kelley AC, Lorsch JR, Ramakrishnan V, Scheres SH. Molecular architecture of a eukaryotic translational initiation complex. Science (New York, N.Y.). 342: 1240585. PMID 24200810 DOI: 10.1126/science.1240585  1
2013 Lorsch J. Preface. Laboratory methods in enzymology: cell, lipid and carbohydrate. Methods in Enzymology. 533: xxi. PMID 24182938 DOI: 10.1016/B978-0-12-420067-8.09988-8  1
2013 Rajagopal V, Lorsch JR. ATP and GTP hydrolysis assays (TLC). Methods in Enzymology. 533: 325-34. PMID 24182937 DOI: 10.1016/B978-0-12-420067-8.00025-8  1
2013 Lorsch J. Methods in Enzymology. Laboratory methods in enzymology: RNA. Preface. Methods in Enzymology. 530: xxi. PMID 24034335 DOI: 10.1016/B978-0-12-420037-1.09986-3  1
2013 Walker SE, Lorsch J. Reverse transcriptase dideoxy sequencing of RNA. Methods in Enzymology. 530: 347-59. PMID 24034332 DOI: 10.1016/B978-0-12-420037-1.00020-8  1
2013 Walker SE, Lorsch J. RNA purification--precipitation methods. Methods in Enzymology. 530: 337-43. PMID 24034331 DOI: 10.1016/B978-0-12-420037-1.00019-1  1
2013 Kolitz S, Lorsch J. Explanatory chapter: nucleic acid concentration determination. Methods in Enzymology. 530: 331-6. PMID 24034330 DOI: 10.1016/B978-0-12-420037-1.00018-X  1
2013 Lorsch J. Methods in Enzymology. Laboratory methods in enzymology: DNA. Preface. Methods in Enzymology. 529: xix. PMID 24011060 DOI: 10.1016/B978-0-12-418687-3.09989-4  1
2013 Walker SE, Lorsch J. Sanger dideoxy sequencing of DNA. Methods in Enzymology. 529: 171-84. PMID 24011045 DOI: 10.1016/B978-0-12-418687-3.00014-8  1
2013 Martin-Marcos P, Nanda J, Luna RE, Wagner G, Lorsch JR, Hinnebusch AG. β-Hairpin loop of eukaryotic initiation factor 1 (eIF1) mediates 40 S ribosome binding to regulate initiator tRNA(Met) recruitment and accuracy of AUG selection in vivo. The Journal of Biological Chemistry. 288: 27546-62. PMID 23893413 DOI: 10.1074/Jbc.M113.498642  1
2013 Nanda JS, Saini AK, Muñoz AM, Hinnebusch AG, Lorsch JR. Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complex. The Journal of Biological Chemistry. 288: 5316-29. PMID 23293029 DOI: 10.1074/Jbc.M112.440693  1
2013 Walker SE, Zhou F, Mitchell SF, Larson VS, Valasek L, Hinnebusch AG, Lorsch JR. Yeast eIF4B binds to the head of the 40S ribosomal subunit and promotes mRNA recruitment through its N-terminal and internal repeat domains. Rna (New York, N.Y.). 19: 191-207. PMID 23236192 DOI: 10.1261/Rna.035881.112  1
2013 Park EH, Walker SE, Zhou F, Lee JM, Rajagopal V, Lorsch JR, Hinnebusch AG. Yeast eukaryotic initiation factor 4B (eIF4B) enhances complex assembly between eIF4A and eIF4G in vivo. The Journal of Biological Chemistry. 288: 2340-54. PMID 23184954 DOI: 10.1074/Jbc.M112.398537  1
2013 Allen RC, Tu YK, Nevarez MJ, Bobbs AS, Friesen JW, Lorsch JR, McCauley JA, Voet JG, Hamlett NV. The mercury resistance (mer) operon in a marine gliding flavobacterium, Tenacibaculum discolor 9A5. Fems Microbiology Ecology. 83: 135-48. PMID 22816663 DOI: 10.1111/j.1574-6941.2012.01460.x  1
2012 Hinnebusch AG, Lorsch JR. The mechanism of eukaryotic translation initiation: new insights and challenges. Cold Spring Harbor Perspectives in Biology. 4. PMID 22815232 DOI: 10.1101/Cshperspect.A011544  1
2012 Luna RE, Arthanari H, Hiraishi H, Nanda J, Martin-Marcos P, Markus MA, Akabayov B, Milbradt AG, Luna LE, Seo HC, Hyberts SG, Fahmy A, Reibarkh M, Miles D, Hagner PR, ... ... Lorsch JR, et al. The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2β. Cell Reports. 1: 689-702. PMID 22813744 DOI: 10.1016/J.Celrep.2012.04.007  1
2012 Aitken CE, Lorsch JR. A mechanistic overview of translation initiation in eukaryotes. Nature Structural & Molecular Biology. 19: 568-76. PMID 22664984 DOI: 10.1038/nsmb.2303  1
2012 Rajagopal V, Park EH, Hinnebusch AG, Lorsch JR. Specific domains in yeast translation initiation factor eIF4G strongly bias RNA unwinding activity of the eIF4F complex toward duplexes with 5'-overhangs. The Journal of Biological Chemistry. 287: 20301-12. PMID 22467875 DOI: 10.1074/Jbc.M112.347278  1
2011 Shin BS, Kim JR, Walker SE, Dong J, Lorsch JR, Dever TE. Initiation factor eIF2γ promotes eIF2-GTP-Met-tRNAi(Met) ternary complex binding to the 40S ribosome. Nature Structural & Molecular Biology. 18: 1227-34. PMID 22002225 DOI: 10.1038/Nsmb.2133  1
2011 Lorsch JR, Nichols DG. Organizing graduate life sciences education around nodes and connections. Cell. 146: 506-9. PMID 21854978 DOI: 10.1016/j.cell.2011.08.004  1
2011 Shin BS, Acker MG, Kim JR, Maher KN, Arefin SM, Lorsch JR, Dever TE. Structural integrity of {alpha}-helix H12 in translation initiation factor eIF5B is critical for 80S complex stability. Rna (New York, N.Y.). 17: 687-96. PMID 21335519 DOI: 10.1261/Rna.2412511  1
2011 Takacs JE, Neary TB, Ingolia NT, Saini AK, Martin-Marcos P, Pelletier J, Hinnebusch AG, Lorsch JR. Identification of compounds that decrease the fidelity of start codon recognition by the eukaryotic translational machinery. Rna (New York, N.Y.). 17: 439-52. PMID 21220547 DOI: 10.1261/Rna.2475211  1
2011 Park EH, Walker SE, Lee JM, Rothenburg S, Lorsch JR, Hinnebusch AG. Multiple elements in the eIF4G1 N-terminus promote assembly of eIF4G1•PABP mRNPs in vivo. The Embo Journal. 30: 302-16. PMID 21139564 DOI: 10.1038/Emboj.2010.312  1
2010 Mitchell SF, Walker SE, Algire MA, Park EH, Hinnebusch AG, Lorsch JR. The 5'-7-methylguanosine cap on eukaryotic mRNAs serves both to stimulate canonical translation initiation and to block an alternative pathway. Molecular Cell. 39: 950-62. PMID 20864040 DOI: 10.1016/J.Molcel.2010.08.021  1
2010 Kurata S, Nielsen KH, Mitchell SF, Lorsch JR, Kaji A, Kaji H. Ribosome recycling step in yeast cytoplasmic protein synthesis is catalyzed by eEF3 and ATP. Proceedings of the National Academy of Sciences of the United States of America. 107: 10854-9. PMID 20534490 DOI: 10.1073/Pnas.1006247107  1
2010 Lorsch JR, Dever TE. Molecular view of 43 S complex formation and start site selection in eukaryotic translation initiation. The Journal of Biological Chemistry. 285: 21203-7. PMID 20444698 DOI: 10.1074/Jbc.R110.119743  1
2010 Saini AK, Nanda JS, Lorsch JR, Hinnebusch AG. Regulatory elements in eIF1A control the fidelity of start codon selection by modulating tRNA(i)(Met) binding to the ribosome. Genes & Development. 24: 97-110. PMID 20048003 DOI: 10.1101/Gad.1871910  1
2010 Kolitz SE, Lorsch JR. Eukaryotic initiator tRNA: finely tuned and ready for action. Febs Letters. 584: 396-404. PMID 19925799 DOI: 10.1016/j.febslet.2009.11.047  1
2009 Nanda JS, Cheung YN, Takacs JE, Martin-Marcos P, Saini AK, Hinnebusch AG, Lorsch JR. eIF1 controls multiple steps in start codon recognition during eukaryotic translation initiation. Journal of Molecular Biology. 394: 268-85. PMID 19751744 DOI: 10.1016/J.Jmb.2009.09.017  1
2009 Kolitz SE, Takacs JE, Lorsch JR. Kinetic and thermodynamic analysis of the role of start codon/anticodon base pairing during eukaryotic translation initiation. Rna (New York, N.Y.). 15: 138-52. PMID 19029312 DOI: 10.1261/rna.1318509  1
2009 Shin BS, Kim JR, Acker MG, Maher KN, Lorsch JR, Dever TE. rRNA suppressor of a eukaryotic translation initiation factor 5B/initiation factor 2 mutant reveals a binding site for translational GTPases on the small ribosomal subunit. Molecular and Cellular Biology. 29: 808-21. PMID 19029250 DOI: 10.1128/Mcb.00896-08  1
2009 Acker MG, Shin BS, Nanda JS, Saini AK, Dever TE, Lorsch JR. Kinetic analysis of late steps of eukaryotic translation initiation. Journal of Molecular Biology. 385: 491-506. PMID 18976658 DOI: 10.1016/J.Jmb.2008.10.029  1
2008 Dong J, Nanda JS, Rahman H, Pruitt MR, Shin BS, Wong CM, Lorsch JR, Hinnebusch AG. Genetic identification of yeast 18S rRNA residues required for efficient recruitment of initiator tRNA(Met) and AUG selection. Genes & Development. 22: 2242-55. PMID 18708582 DOI: 10.1101/Gad.1696608  1
2008 Acker MG, Lorsch JR. Mechanism of ribosomal subunit joining during eukaryotic translation initiation. Biochemical Society Transactions. 36: 653-7. PMID 18631135 DOI: 10.1042/BST0360653  1
2008 Mitchell SF, Lorsch JR. Should I stay or should I go? Eukaryotic translation initiation factors 1 and 1A control start codon recognition. The Journal of Biological Chemistry. 283: 27345-9. PMID 18593708 DOI: 10.1074/jbc.R800031200  1
2007 Acker MG, Kolitz SE, Mitchell SF, Nanda JS, Lorsch JR. Reconstitution of yeast translation initiation. Methods in Enzymology. 430: 111-45. PMID 17913637 DOI: 10.1016/S0076-6879(07)30006-2  1
2007 Cheung YN, Maag D, Mitchell SF, Fekete CA, Algire MA, Takacs JE, Shirokikh N, Pestova T, Lorsch JR, Hinnebusch AG. Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo. Genes & Development. 21: 1217-30. PMID 17504939 DOI: 10.1101/Gad.1528307  1
2007 Passmore LA, Schmeing TM, Maag D, Applefield DJ, Acker MG, Algire MA, Lorsch JR, Ramakrishnan V. The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome. Molecular Cell. 26: 41-50. PMID 17434125 DOI: 10.1016/J.Molcel.2007.03.018  1
2007 Fekete CA, Mitchell SF, Cherkasova VA, Applefield D, Algire MA, Maag D, Saini AK, Lorsch JR, Hinnebusch AG. N- and C-terminal residues of eIF1A have opposing effects on the fidelity of start codon selection. The Embo Journal. 26: 1602-14. PMID 17332751 DOI: 10.1038/Sj.Emboj.7601613  1
2007 Fringer JM, Acker MG, Fekete CA, Lorsch JR, Dever TE. Coupled release of eukaryotic translation initiation factors 5B and 1A from 80S ribosomes following subunit joining. Molecular and Cellular Biology. 27: 2384-97. PMID 17242201 DOI: 10.1128/Mcb.02254-06  1
2007 Shin BS, Acker MG, Maag D, Kim JR, Lorsch JR, Dever TE. Intragenic suppressor mutations restore GTPase and translation functions of a eukaryotic initiation factor 5B switch II mutant. Molecular and Cellular Biology. 27: 1677-85. PMID 17189426 DOI: 10.1128/Mcb.01258-06  1
2006 Algire MA, Lorsch JR. Where to begin? The mechanism of translation initiation codon selection in eukaryotes. Current Opinion in Chemical Biology. 10: 480-6. PMID 16935023 DOI: 10.1016/j.cbpa.2006.08.010  1
2006 Robert F, Kapp LD, Khan SN, Acker MG, Kolitz S, Kazemi S, Kaufman RJ, Merrick WC, Koromilas AE, Lorsch JR, Pelletier J. Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability. Molecular Biology of the Cell. 17: 4632-44. PMID 16928960 DOI: 10.1091/Mbc.E06-06-0478  1
2006 Kapp LD, Kolitz SE, Lorsch JR. Yeast initiator tRNA identity elements cooperate to influence multiple steps of translation initiation. Rna (New York, N.Y.). 12: 751-64. PMID 16565414 DOI: 10.1261/rna.2263906  1
2006 Acker MG, Shin BS, Dever TE, Lorsch JR. Interaction between eukaryotic initiation factors 1A and 5B is required for efficient ribosomal subunit joining. The Journal of Biological Chemistry. 281: 8469-75. PMID 16461768 DOI: 10.1074/Jbc.M600210200  1
2006 Maag D, Algire MA, Lorsch JR. Communication between eukaryotic translation initiation factors 5 and 1A within the ribosomal pre-initiation complex plays a role in start site selection. Journal of Molecular Biology. 356: 724-37. PMID 16380131 DOI: 10.1016/j.jmb.2005.11.083  1
2005 Algire MA, Maag D, Lorsch JR. Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiation. Molecular Cell. 20: 251-62. PMID 16246727 DOI: 10.1016/j.molcel.2005.09.008  1
2005 Fekete CA, Applefield DJ, Blakely SA, Shirokikh N, Pestova T, Lorsch JR, Hinnebusch AG. The eIF1A C-terminal domain promotes initiation complex assembly, scanning and AUG selection in vivo. The Embo Journal. 24: 3588-601. PMID 16193068 DOI: 10.1038/Sj.Emboj.7600821  1
2005 Doudna JA, Lorsch JR. Ribozyme catalysis: not different, just worse. Nature Structural & Molecular Biology. 12: 395-402. PMID 15870731 DOI: 10.1038/Nsmb932  1
2005 Maag D, Fekete CA, Gryczynski Z, Lorsch JR. A conformational change in the eukaryotic translation preinitiation complex and release of eIF1 signal recognition of the start codon. Molecular Cell. 17: 265-75. PMID 15664195 DOI: 10.1016/J.Molcel.2004.11.051  1
2004 Kapp LD, Lorsch JR. The molecular mechanics of eukaryotic translation. Annual Review of Biochemistry. 73: 657-704. PMID 15189156 DOI: 10.1146/annurev.biochem.73.030403.080419  1
2004 Kapp LD, Lorsch JR. GTP-dependent recognition of the methionine moiety on initiator tRNA by translation factor eIF2. Journal of Molecular Biology. 335: 923-36. PMID 14698289 DOI: 10.1016/j.jmb.2003.11.025  1
2003 Maag D, Lorsch JR. Communication between eukaryotic translation initiation factors 1 and 1A on the yeast small ribosomal subunit. Journal of Molecular Biology. 330: 917-24. PMID 12860115 DOI: 10.1016/S0022-2836(03)00665-X  1
2002 Shin BS, Maag D, Roll-Mecak A, Arefin MS, Burley SK, Lorsch JR, Dever TE. Uncoupling of initiation factor eIF5B/IF2 GTPase and translational activities by mutations that lower ribosome affinity. Cell. 111: 1015-25. PMID 12507428 DOI: 10.1016/S0092-8674(02)01171-6  1
2002 Carriere M, Vijayabaskar V, Applefield D, Harvey I, Garneau P, Lorsch J, Lapidot A, Pelletier J. Inhibition of protein synthesis by aminoglycoside-arginine conjugates. Rna (New York, N.Y.). 8: 1267-79. PMID 12403465 DOI: 10.1017/S1355838202029059  1
2002 Green R, Lorsch JR. The path to perdition is paved with protons. Cell. 110: 665-8. PMID 12297040 DOI: 10.1016/S0092-8674(02)00965-0  1
2002 Lorsch JR. RNA chaperones exist and DEAD box proteins get a life. Cell. 109: 797-800. PMID 12110176 DOI: 10.1016/S0092-8674(02)00804-8  1
2002 Algire MA, Maag D, Savio P, Acker MG, Tarun SZ, Sachs AB, Asano K, Nielsen KH, Olsen DS, Phan L, Hinnebusch AG, Lorsch JR. Development and characterization of a reconstituted yeast translation initiation system. Rna (New York, N.Y.). 8: 382-97. PMID 12008673 DOI: 10.1017/S1355838202029527  1
2001 Berg JM, Lorsch JR. Mechanism of ribosomal peptide bond formation. Science (New York, N.Y.). 291: 203. PMID 11406869  1
1999 Lorsch JR, Herschlag D. Kinetic dissection of fundamental processes of eukaryotic translation initiation in vitro. The Embo Journal. 18: 6705-17. PMID 10581244 DOI: 10.1093/Emboj/18.23.6705  1
1998 Lorsch JR, Herschlag D. The DEAD box protein eIF4A. 2. A cycle of nucleotide and RNA-dependent conformational changes. Biochemistry. 37: 2194-206. PMID 9485365 DOI: 10.1021/Bi9724319  1
1998 Lorsch JR, Herschlag D. The DEAD box protein eIF4A. 1. A minimal kinetic and thermodynamic framework reveals coupled binding of RNA and nucleotide. Biochemistry. 37: 2180-93. PMID 9485364 DOI: 10.1021/Bi972430G  1
1996 Lorsch JR, Szostak JW. Chance and necessity in the selection of nucleic acid catalysts. Accounts of Chemical Research. 29: 103-10. PMID 11539421 DOI: 10.1021/Ar9501378  1
1995 Lorsch JR, Szostak JW. Kinetic and thermodynamic characterization of the reaction catalyzed by a polynucleotide kinase ribozyme. Biochemistry. 34: 15315-27. PMID 7578148 DOI: 10.1021/Bi00046A041  1
1995 Lorsch JR, Bartel DP, Szostak JW. Reverse transcriptase reads through a 2'-5'linkage and a 2'-thiophosphate in a template. Nucleic Acids Research. 23: 2811-4. PMID 7544885 DOI: 10.1093/Nar/23.15.2811  1
1994 Lorsch JR, Szostak JW. In vitro evolution of new ribozymes with polynucleotide kinase activity. Nature. 371: 31-6. PMID 7521014 DOI: 10.1038/371031A0  1
1994 Lorsch JR, Szostak JW. In vitro selection of RNA aptamers specific for cyanocobalamin. Biochemistry. 33: 973-82. PMID 7508262 DOI: 10.1021/Bi00170A016  1
1986 Ruprecht RM, Lorsch J, Trites DH. Analysis of suramin plasma levels by ion-pair high-performance liquid chromatography under isocratic conditions. Journal of Chromatography. 378: 498-502. PMID 3734007 DOI: 10.1016/S0378-4347(00)80750-1  1
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