Rene Maltais, Ph.D. - Publications

Affiliations: 
2001 Universite Laval (Canada) 
Area:
Pharmaceutical Chemistry

57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Boutin S, Maltais R, Roy J, Poirier D. Synthesis of 17β-hydroxysteroid dehydrogenase type 10 steroidal inhibitors: Selectivity, metabolic stability and enhanced potency. European Journal of Medicinal Chemistry. 112909. PMID 33081987 DOI: 10.1016/j.ejmech.2020.112909  1
2020 Maltais R, Ngueta Djiemeny A, Roy J, Barbeau X, Lambert JP, Poirier D. Design and synthesis of dansyl-labeled inhibitors of steroid sulfatase for optical imaging. Bioorganic & Medicinal Chemistry. 115368. PMID 32122754 DOI: 10.1016/j.bmc.2020.115368  1
2019 Maltais R, Perreault M, Roy J, Poirier D. Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility. European Journal of Medicinal Chemistry. 188: 111990. PMID 31893547 DOI: 10.1016/j.ejmech.2019.111990  1
2019 Boutin S, Roy J, Maltais R, Poirier D. Formation of 5α-dihydrotestosterone from 5α-androstane-3α,17β-diol in prostate cancer LAPC-4 cells - Identifying inhibitors of non-classical pathways producing the most potent androgen. Bioorganic & Medicinal Chemistry Letters. 126783. PMID 31753699 DOI: 10.1016/j.bmcl.2019.126783  1
2019 Cortés-Benítez F, Roy J, Perreault M, Maltais R, Poirier D. A- and D-ring structural modifications of an androsterone derivative inhibiting 17β-hydroxysteroid dehydrogenase type 3: Chemical synthesis and structure-activity relationships. Journal of Medicinal Chemistry. PMID 31268309 DOI: 10.1021/acs.jmedchem.9b00624  1
2019 Poirier D, Roy J, Maltais R, Ayan D. Antisulfatase, osteogenic and anticancer activities of steroid sulfatase inhibitor EO-33 in mice. Journal of Medicinal Chemistry. PMID 31062594 DOI: 10.1021/acs.jmedchem.9b00382  1
2018 Sancéau JY, Maltais R, Poirier D, Marette A. Total Synthesis of the Antidiabetic (Type 2) Lipid Mediator Protectin DX/PDX. The Journal of Organic Chemistry. PMID 30586310 DOI: 10.1021/acs.joc.8b01973  1
2018 Boutin S, Roy J, Maltais R, Alata W, Calon F, Poirier D. Identification of steroidal derivatives inhibiting the transformations of allopregnanolone and estradiol by 17β-hydroxysteroid dehydrogenase type 10. Bioorganic & Medicinal Chemistry Letters. PMID 30297283 DOI: 10.1016/j.bmcl.2018.09.031  1
2018 Lespérance M, Barbeau X, Roy J, Maltais R, Lagüe P, Poirier D. Chemical Synthesis of C3-oxiranyl/oxiranylmethyl-estrane derivatives targeted by molecular modeling and tested as potential inhibitors of 17β-hydroxysteroid dehydrogenase type 1. Steroids. PMID 30273695 DOI: 10.1016/j.steroids.2018.09.009  1
2018 Dutour R, Roy J, Cortés-Benítez F, Maltais R, Poirier D. Targeting Cytochrome P450 (CYP) 1B1 Enzyme with Four Series of A-ring Substituted Estrane Derivatives: Design, Synthesis, Inhibitory Activity and Selectivity. Journal of Medicinal Chemistry. PMID 30216063 DOI: 10.1021/acs.jmedchem.8b00907  1
2018 Li T, Maltais R, Poirier D, Lin SX. Combined Biophysical Chemistry Reveals the Finding of a New Covalent Inhibitor with a Low-Reactive Alkyl Halide. The Journal of Physical Chemistry Letters. PMID 30148957 DOI: 10.1021/acs.jpclett.8b02225  1
2018 Perreault M, Maltais R, Roy J, Picard S, Popa I, Bertrand N, Poirier D. Induction of endoplasmic reticulum stress by aminosteroid derivative RM-581 leads to tumor regression in PANC-1 xenograft model. Investigational New Drugs. PMID 30062573 DOI: 10.1007/s10637-018-0643-4  1
2018 Dutour R, Maltais R, Perreault M, Roy J, Poirier D. Parallel Solid-Phase Synthesis Using a New Diethylsilylacetylenic Linker and Leading to Mestranol Derivatives with Potent Antiproliferative Activities on Multiple Cancer Cell Lines. Anti-Cancer Agents in Medicinal Chemistry. PMID 29521249 DOI: 10.2174/1871520618666180307130158  1
2017 Perreault M, Maltais R, Kenmogne LC, Létourneau D, LeHoux JG, Gobeil S, Poirier D. Implication of STARD5 and cholesterol homeostasis disturbance in the endoplasmic reticulum stress-related response induced by pro-apoptotic aminosteroid RM-133. Pharmacological Research. PMID 29287690 DOI: 10.1016/j.phrs.2017.12.024  1
2017 Maltais R, Trottier A, Roy J, Ayan D, Bertrand N, Poirier D. Pharmacokinetic profile of PBRM in rodents, a first selective covalent inhibitor of 17β-HSD1 for breast cancer and endometriosis treatments. The Journal of Steroid Biochemistry and Molecular Biology. PMID 29248731 DOI: 10.1016/j.jsbmb.2017.12.007  1
2017 Trottier A, Maltais R, Ayan D, Barbeau X, Roy J, Perreault M, Poulin R, Lagüe P, Poirier D. Insight into the mode of action and selectivity of PBRM, a covalent steroidal inhibitor of 17β-hydroxysteroid dehydrogenase type 1. Biochemical Pharmacology. PMID 28800957 DOI: 10.1016/j.bcp.2017.08.004  1
2017 Cortés-Benítez F, Roy J, Maltais R, Poirier D. Impact of androstane A- and D-ring inversion on 17β-hydroxysteroid dehydrogenase type 3 inhibitory activity, androgenic effect and metabolic stability. Bioorganic & Medicinal Chemistry. PMID 28254377 DOI: 10.1016/j.bmc.2017.02.008  1
2017 Kenmogne LC, Roy J, Maltais R, Rouleau M, Neveu B, Pouliot F, Poirier D. Investigation of the In Vitro and In Vivo efficiency of RM-532-105, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, in LAPC-4 prostate cancer cell and tumor models. Plos One. 12: e0171871. PMID 28182747 DOI: 10.1371/journal.pone.0171871  1
2017 Perreault M, Maltais R, Roy J, Dutour R, Poirier D. Design of a Mestranol 2-N-Piperazino-Substituted Derivative Showing Potent and Selective in vitro and in vivo Activities in MCF-7 Breast Cancer Models. Chemmedchem. PMID 28060448 DOI: 10.1002/cmdc.201600482  1
2016 Perreault M, Maltais R, Dutour R, Poirier D. Explorative study on the anticancer activity, selectivity and metabolic stability of related analogs of aminosteroid RM-133. Steroids. PMID 27553727 DOI: 10.1016/j.steroids.2016.08.015  1
2016 Ouellet C, Maltais R, Ouellet É, Barbeau X, Lagüe P, Poirier D. Discovery of a sulfamate-based steroid sulfatase inhibitor with intrinsic selective estrogen receptor modulator properties. European Journal of Medicinal Chemistry. 119: 169-182. PMID 27155470 DOI: 10.1016/j.ejmech.2016.04.044  1
2016 Kenmogne LC, Maltais R, Poirier D. Synthesis of a dansyl-labeled inhibitor of 17β-hydroxysteroid dehydrogenase type 3 for optical imaging. Bioorganic & Medicinal Chemistry Letters. 26: 2179-83. PMID 27025340 DOI: 10.1016/j.bmcl.2016.03.069  1
2015 Talbot A, Maltais R, Kenmogne LC, Roy J, Poirier D. Solid-phase synthesis of libraries of ethynylated aminosteroid derivatives as potential antileukemic agents. Steroids. PMID 26742630 DOI: 10.1016/j.steroids.2015.12.019  1
2015 Kenmogne LC, Ayan D, Roy J, Maltais R, Poirier D. The Aminosteroid Derivative RM-133 Shows In Vitro and In Vivo Antitumor Activity in Human Ovarian and Pancreatic Cancers. Plos One. 10: e0144890. PMID 26660672 DOI: 10.1371/journal.pone.0144890  1
2015 Maltais R, Trottier A, Barbeau X, Lagüe P, Perreault M, Thériault JF, Lin SX, Poirier D. Impact of structural modifications at positions 13, 16 and 17 of 16β-(m-carbamoylbenzyl)-estradiol on 17β-hydroxysteroid dehydrogenase type 1 inhibition and estrogenic activity. The Journal of Steroid Biochemistry and Molecular Biology. PMID 26519987 DOI: 10.1016/j.jsbmb.2015.10.020  1
2015 Roy J, Fournier MA, Maltais R, Kenmogne LC, Poirier D. Reprint of "In vitro and in vivo evaluation of a 3β-androsterone derivative as inhibitor of 17β-hydroxysteroid dehydrogenase type 3". The Journal of Steroid Biochemistry and Molecular Biology. 153: 170-8. PMID 26291835 DOI: 10.1016/j.jsbmb.2015.08.014  1
2015 Djigoué GB, Kenmogne LC, Roy J, Maltais R, Poirier D. Design, chemical synthesis and biological evaluation of 3-spiromorpholinone/3-spirocarbamate androsterone derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 3. Bioorganic & Medicinal Chemistry. 23: 5433-51. PMID 26277760 DOI: 10.1016/j.bmc.2015.07.049  1
2015 Maltais R, Trottier A, Delhomme A, Barbeau X, Lagüe P, Poirier D. Identification of fused 16β,17β-oxazinone-estradiol derivatives as a new family of non-estrogenic 17β-hydroxysteroid dehydrogenase type 1 inhibitors. European Journal of Medicinal Chemistry. 93: 470-80. PMID 25728028 DOI: 10.1016/j.ejmech.2015.01.059  1
2014 Ayan D, Maltais R, Hospital A, Poirier D. Chemical synthesis, cytotoxicity, selectivity and bioavailability of 5α-androstane-3α,17β-diol derivatives. Bioorganic & Medicinal Chemistry. 22: 5847-59. PMID 25300820 DOI: 10.1016/j.bmc.2014.09.026  1
2014 Djigoué GB, Maltais R, Poirier D. Development of a simple and efficient solution-phase parallel synthesis of flexible non-steroidal estradiol mimics. Combinatorial Chemistry & High Throughput Screening. 17: 734-44. PMID 25230027  1
2014 Trottier A, Maltais R, Poirier D. Identification of a first enzymatic activator of a 17β-hydroxysteroid dehydrogenase. Acs Chemical Biology. 9: 1668-73. PMID 24910887 DOI: 10.1021/cb500109e  1
2014 Maltais R, Hospital A, Delhomme A, Roy J, Poirier D. Chemical synthesis, NMR analysis and evaluation on a cancer xenograft model (HL-60) of the aminosteroid derivative RM-133. Steroids. 82: 68-76. PMID 24486462 DOI: 10.1016/j.steroids.2014.01.008  1
2014 Roy J, Fournier MA, Maltais R, Kenmogne LC, Poirier D. In vitro and in vivo evaluation of a 3β-androsterone derivative as inhibitor of 17β-hydroxysteroid dehydrogenase type 3. The Journal of Steroid Biochemistry and Molecular Biology. 141: 44-51. PMID 24434282 DOI: 10.1016/j.jsbmb.2013.12.019  1
2014 Maltais R, Ayan D, Trottier A, Barbeau X, Lagüe P, Bouchard JE, Poirier D. Discovery of a non-estrogenic irreversible inhibitor of 17β-hydroxysteroid dehydrogenase type 1 from 3-substituted-16β-(m-carbamoylbenzyl)-estradiol derivatives. Journal of Medicinal Chemistry. 57: 204-22. PMID 24328103 DOI: 10.1021/jm401639v  1
2014 Talbot A, Maltais R, Poirier D. Synthesis of an estradiol derivative with an adenosine-phosphate mimic linked at position 16β Current Organic Synthesis. 11: 612-620. DOI: 10.2174/15701794113106660078  1
2013 Roy J, Lefebvre J, Maltais R, Poirier D. Inhibition of dehydroepiandosterone sulfate action in androgen-sensitive tissues by EM-1913, an inhibitor of steroid sulfatase Molecular and Cellular Endocrinology. 376: 148-155. PMID 23806558 DOI: 10.1016/j.mce.2013.06.022  1
2013 Ajeawung NF, Maltais R, Jones C, Poirier D, Kamnasaran D. Viability screen on pediatric low grade glioma cell lines unveils a novel anti-cancer drug of the steroid biosynthesis inhibitor family. Cancer Letters. 330: 96-105. PMID 23201138 DOI: 10.1016/j.canlet.2012.11.034  1
2012 Ayan D, Maltais R, Roy J, Poirier D. A new nonestrogenic steroidal inhibitor of 17β-hydroxysteroid dehydrogenase type I blocks the estrogen-dependent breast cancer tumor growth induced by estrone. Molecular Cancer Therapeutics. 11: 2096-104. PMID 22914440 DOI: 10.1158/1535-7163.MCT-12-0299  1
2012 Jegham H, Maltais R, Dufour P, Roy J, Poirier D. Solid-phase chemical synthesis and in vitro biological evaluation of novel 2β-piperazino-(20R)-5α-pregnane-3α,20-diol N-derivatives as anti-leukemic agents. Steroids. 77: 1403-18. PMID 22910290 DOI: 10.1016/j.steroids.2012.07.012  1
2012 Ayan D, Maltais R, Poirier D. Identification of a 17β-hydroxysteroid dehydrogenase type 10 steroidal inhibitor: a tool to investigate the role of type 10 in Alzheimer's disease and prostate cancer. Chemmedchem. 7: 1181-4. PMID 22674910 DOI: 10.1002/cmdc.201200129  1
2012 Talbot A, Maltais R, Poirier D. New diethylsilylacetylenic linker for parallel solid-phase synthesis of libraries of hydroxy acetylenic steroid derivatives with improved metabolic stability. Acs Combinatorial Science. 14: 347-51. PMID 22587990 DOI: 10.1021/co300034y  1
2012 Jegham H, Maltais R, Roy J, Doillon C, Poirier D. Biological evaluation of a new family of aminosteroids that display a selective toxicity for various malignant cell lines. Anti-Cancer Drugs. 23: 803-14. PMID 22361842 DOI: 10.1097/CAD.0b013e328351aa8c  1
2012 Jegham H, Roy J, Maltais R, Desnoyers S, Poirier D. A novel aminosteroid of the 5α-androstane-3α,17β-diol family induces cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells. Investigational New Drugs. 30: 176-85. PMID 20890632 DOI: 10.1007/s10637-010-9548-6  1
2012 Maltais R, Poirier D. Diversity-oriented synthesis of spiro-and fused azacycles from ketone molecular templates European Journal of Organic Chemistry. 5435-5439. DOI: 10.1002/ejoc.201200852  1
2011 Maltais R, Ayan D, Poirier D. Crucial Role of 3-Bromoethyl in Removing the Estrogenic Activity of 17β-HSD1 Inhibitor 16β-(m-Carbamoylbenzyl)estradiol. Acs Medicinal Chemistry Letters. 2: 678-681. PMID 21927646 DOI: 10.1021/ml200093v  1
2011 Ayan D, Roy J, Maltais R, Poirier D. Impact of estradiol structural modifications (18-methyl and/or 17-hydroxy inversion of configuration) on the in vitro and in vivo estrogenic activity. The Journal of Steroid Biochemistry and Molecular Biology. 127: 324-30. PMID 21827856 DOI: 10.1016/j.jsbmb.2011.07.009  1
2011 Maltais R, Fournier MA, Poirier D. Development of 3-substituted-androsterone derivatives as potent inhibitors of 17β-hydroxysteroid dehydrogenase type 3. Bioorganic & Medicinal Chemistry. 19: 4652-68. PMID 21741247 DOI: 10.1016/j.bmc.2011.06.003  1
2011 Maltais R, Poirier D. Steroid sulfatase inhibitors: a review covering the promising 2000-2010 decade. Steroids. 76: 929-48. PMID 21458474 DOI: 10.1016/j.steroids.2011.03.010  1
2011 Roy J, Maltais R, Jegham H, Poirier D. Libraries of 2β-(N-substituted piperazino)-5α-androstane-3α, 17β-diols: chemical synthesis and cytotoxic effects on human leukemia HL-60 cells and on normal lymphocytes. Molecular Diversity. 15: 317-39. PMID 20827507 DOI: 10.1007/s11030-010-9273-2  1
2009 Maltais R, Fournier D, Poirier D. Quantitative structure-activity relationship (QSAR) study with a series of 17α-derivatives of estradiol: Model for the development of reversible steroid sulfatase inhibitors Qsar and Combinatorial Science. 28: 1284-1299. DOI: 10.1002/qsar.200960028  1
2006 Poirier D, Maltais R. Solid-phase organic synthesis (SPOS) of modulators of estrogenic and androgenic action. Mini Reviews in Medicinal Chemistry. 6: 37-52. PMID 16457631 DOI: 10.2174/138955706775197802  1
2005 Maltais R, Mercier C, Labrie F, Poirier D. Solid-phase synthesis of model libraries of 3alpha,17beta-dihydroxy-16alpha-(aminoethyl-N-substituted)-5alpha-androstanes for the development of steroidal therapeutic agents. Molecular Diversity. 9: 67-79. PMID 15789554 DOI: 10.1007/s11030-005-1312-z  1
2004 Maltais R, Tremblay MR, Ciobanu LC, Poirier D. Steroids and combinatorial chemistry. Journal of Combinatorial Chemistry. 6: 443-56. PMID 15244402 DOI: 10.1021/cc030118m  1
2002 Maltais R, Luu-The V, Poirier D. Synthesis and optimization of a new family of type 3 17 beta-hydroxysteroid dehydrogenase inhibitors by parallel liquid-phase chemistry. Journal of Medicinal Chemistry. 45: 640-53. PMID 11806715 DOI: 10.1021/jm010286y  1
2001 Maltais R, Luu-The V, Poirier D. Parallel solid-phase synthesis of 3β-peptido-3α-hydroxy-5α-androstan-17-one derivatives for inhibition of Type 3 17β-hydroxysteroid dehydrogenase Bioorganic and Medicinal Chemistry. 9: 3101-3111. PMID 11711285 DOI: 10.1016/S0968-0896(01)00182-1  1
2000 Maltais R, Tremblay MR, Poirier D. Solid-phase synthesis of hydroxysteroid derivatives using the diethylsilyloxy linker Journal of Combinatorial Chemistry. 2: 604-614. PMID 11126290 DOI: 10.1021/cc0000242  1
1998 Maltais R, Poirier D. A solution-phase combinatorial parallel synthesis of 3β-amido-3α- hydroxy 5α-androstane-17-ones Tetrahedron Letters. 39: 4151-4154. DOI: 10.1016/S0040-4039(98)00772-2  1
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