| Year |
Citation |
Score |
| 2024 |
Fortin N, Hénaut M, Goyette N, Maltais R, Sancéau JY, Marette A, Poirier D, Abed Y, Boivin G. A protectin DX (PDX) analog with in vitro activity against influenza A(H1N1) viruses. Journal of Medical Virology. 96: e29484. PMID 38402600 DOI: 10.1002/jmv.29484 |
0.463 |
|
| 2023 |
Burguin A, Roy J, Ouellette G, Maltais R, Bherer J, Diorio C, Poirier D, Durocher F. Aminosteroid RM-581 Decreases Cell Proliferation of All Breast Cancer Molecular Subtypes, Alone and in Combination with Breast Cancer Treatments. Journal of Clinical Medicine. 12. PMID 37445276 DOI: 10.3390/jcm12134241 |
0.499 |
|
| 2023 |
Poirier D, Roy J, Maltais R, Weidmann C, Audet-Walsh É. An Aminosteroid Derivative Shows Higher In Vitro and In Vivo Potencies than Gold Standard Drugs in Androgen-Dependent Prostate Cancer Models. Cancers. 15. PMID 37296995 DOI: 10.3390/cancers15113033 |
0.505 |
|
| 2023 |
Maltais R, Sancéau JY, Poirier D, Marette A. A Concise, Gram-Scale Total Synthesis of Protectin DX and Related Labeled Versions via a Key Stereoselective Reduction of Enediyne. The Journal of Organic Chemistry. PMID 37172290 DOI: 10.1021/acs.joc.3c00360 |
0.484 |
|
| 2023 |
Ngueta AD, Roy J, Maltais R, Poirier D. Chemical Synthesis and Biological Evaluation of 3-Substituted Estrone/Estradiol Derivatives as 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors Acting via a Reverse Orientation of the Natural Substrate Estrone. Molecules (Basel, Switzerland). 28. PMID 36677690 DOI: 10.3390/molecules28020632 |
0.631 |
|
| 2022 |
Poirier D, Maltais R, Rousseau JA, Roy J, Phoenix S, Cortés-Benítez F, Lecomte R. Chemical synthesis of fluorinated and iodinated 17β-HSD3 inhibitors and evaluation for imaging prostate cancer tumors and tissue biodistribution. Bioorganic Chemistry. 129: 106145. PMID 36174444 DOI: 10.1016/j.bioorg.2022.106145 |
0.602 |
|
| 2022 |
Poirier D, Nyachieo A, Romano A, Roy J, Maltais R, Chai D, Delvoux B, Tomassetti C, Vanhie A. An irreversible inhibitor of 17β-hydroxysteroid dehydrogenase type 1 inhibits estradiol synthesis in human endometriosis lesions and induces regression of the non-human primate endometriosis model. The Journal of Steroid Biochemistry and Molecular Biology. 106136. PMID 35691460 DOI: 10.1016/j.jsbmb.2022.106136 |
0.567 |
|
| 2022 |
Sancéau JY, Bélanger P, Maltais R, Poirier D. An Improved Synthesis of Glucuronide Metabolites of Hindered Phenolic Xenoestrogens. Current Organic Synthesis. PMID 35473530 DOI: 10.2174/1570179419666220426104848 |
0.438 |
|
| 2021 |
Maltais R, Roy J, Perreault M, Sato S, Lévesque JC, Poirier D. Induction of Endoplasmic Reticulum Stress-Mediated Apoptosis by Aminosteroid RM-581 Efficiently Blocks the Growth of PC-3 Cancer Cells and Tumors Resistant or Not to Docetaxel. International Journal of Molecular Sciences. 22. PMID 34681843 DOI: 10.3390/ijms222011181 |
0.507 |
|
| 2021 |
Maltais R, Roy J, Poirier D. Turning a Quinoline-based Steroidal Anticancer Agent into Fluorescent Dye for its Tracking by Cell Imaging. Acs Medicinal Chemistry Letters. 12: 822-826. PMID 34055232 DOI: 10.1021/acsmedchemlett.1c00111 |
0.505 |
|
| 2021 |
Lespérance M, Roy J, Djiemeny Ngueta A, Maltais R, Poirier D. Synthesis of 16β-derivatives of 3-(2-bromoethyl)-estra-1,3,5(10)-trien-17β-ol as inhibitors of 17β-HSD1 and/or steroid sulfatase for the treatment of estrogen-dependent diseases. Steroids. 108856. PMID 33945801 DOI: 10.1016/j.steroids.2021.108856 |
0.653 |
|
| 2021 |
Poirier D, Roy J, Maltais R. A Targeted-Covalent Inhibitor of 17β-HSD1 Blocks Two Estrogen-Biosynthesis Pathways: In Vitro (Metabolism) and In Vivo (Xenograft) Studies in T-47D Breast Cancer Models. Cancers. 13. PMID 33924352 DOI: 10.3390/cancers13081841 |
0.613 |
|
| 2021 |
Cortés-Benítez F, Roy J, Perreault M, Maltais R, Poirier D. 16-Picolyl-androsterone derivative exhibits potent 17β-HSD3 inhibitory activity, improved metabolic stability and cytotoxic effect on various cancer cells: Synthesis, homology modeling and docking studies. The Journal of Steroid Biochemistry and Molecular Biology. 105846. PMID 33609690 DOI: 10.1016/j.jsbmb.2021.105846 |
0.624 |
|
| 2020 |
Boutin S, Maltais R, Roy J, Poirier D. Synthesis of 17β-hydroxysteroid dehydrogenase type 10 steroidal inhibitors: Selectivity, metabolic stability and enhanced potency. European Journal of Medicinal Chemistry. 112909. PMID 33081987 DOI: 10.1016/j.ejmech.2020.112909 |
0.635 |
|
| 2020 |
Maltais R, Ngueta Djiemeny A, Roy J, Barbeau X, Lambert JP, Poirier D. Design and synthesis of dansyl-labeled inhibitors of steroid sulfatase for optical imaging. Bioorganic & Medicinal Chemistry. 115368. PMID 32122754 DOI: 10.1016/J.Bmc.2020.115368 |
0.617 |
|
| 2020 |
Stephen P, Roy J, Maltais R, Poirier D. Insight into the Mechanism of 17β-Hydroxysteroid Dehydrogenase Type 3 Inhibition by the Androsterone Derivative RM-532-105 Current Enzyme Inhibition. 16: 243-250. DOI: 10.2174/1573408016999200729110245 |
0.659 |
|
| 2020 |
Darveau P, Maltais R, Roy J, Poirier D, Morin J. Synthesis and pharmacokinetic study of poly(ethylene oxide) triazole dendrimers decorated with aminosteroids as anticancer agent Journal of Polymer Science. 58: 654-661. DOI: 10.1002/Pol.20190042 |
0.525 |
|
| 2019 |
Maltais R, Perreault M, Roy J, Poirier D. Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility. European Journal of Medicinal Chemistry. 188: 111990. PMID 31893547 DOI: 10.1016/J.Ejmech.2019.111990 |
0.592 |
|
| 2019 |
Boutin S, Roy J, Maltais R, Poirier D. Formation of 5α-dihydrotestosterone from 5α-androstane-3α,17β-diol in prostate cancer LAPC-4 cells - Identifying inhibitors of non-classical pathways producing the most potent androgen. Bioorganic & Medicinal Chemistry Letters. 126783. PMID 31753699 DOI: 10.1016/J.Bmcl.2019.126783 |
0.619 |
|
| 2019 |
Cortés-Benítez F, Roy J, Perreault M, Maltais R, Poirier D. A- and D-ring structural modifications of an androsterone derivative inhibiting 17β-hydroxysteroid dehydrogenase type 3: Chemical synthesis and structure-activity relationships. Journal of Medicinal Chemistry. PMID 31268309 DOI: 10.1021/Acs.Jmedchem.9B00624 |
0.672 |
|
| 2019 |
Poirier D, Roy J, Maltais R, Ayan D. Antisulfatase, osteogenic and anticancer activities of steroid sulfatase inhibitor EO-33 in mice. Journal of Medicinal Chemistry. PMID 31062594 DOI: 10.1021/Acs.Jmedchem.9B00382 |
0.579 |
|
| 2019 |
Maltais R, Poirier D. Development of a Gram-Scale Synthesis of PBRM, an Irreversible Inhibitor of 17β-Hydroxysteroid Dehydrogenase Type 1 Organic Process Research & Development. 23: 2323-2335. DOI: 10.1021/Acs.Oprd.8B00402 |
0.633 |
|
| 2018 |
Sancéau JY, Maltais R, Poirier D, Marette A. Total Synthesis of the Antidiabetic (Type 2) Lipid Mediator Protectin DX/PDX. The Journal of Organic Chemistry. PMID 30586310 DOI: 10.1021/Acs.Joc.8B01973 |
0.547 |
|
| 2018 |
Boutin S, Roy J, Maltais R, Alata W, Calon F, Poirier D. Identification of steroidal derivatives inhibiting the transformations of allopregnanolone and estradiol by 17β-hydroxysteroid dehydrogenase type 10. Bioorganic & Medicinal Chemistry Letters. PMID 30297283 DOI: 10.1016/J.Bmcl.2018.09.031 |
0.673 |
|
| 2018 |
Lespérance M, Barbeau X, Roy J, Maltais R, Lagüe P, Poirier D. Chemical Synthesis of C3-oxiranyl/oxiranylmethyl-estrane derivatives targeted by molecular modeling and tested as potential inhibitors of 17β-hydroxysteroid dehydrogenase type 1. Steroids. PMID 30273695 DOI: 10.1016/J.Steroids.2018.09.009 |
0.68 |
|
| 2018 |
Dutour R, Roy J, Cortés-Benítez F, Maltais R, Poirier D. Targeting Cytochrome P450 (CYP) 1B1 Enzyme with Four Series of A-ring Substituted Estrane Derivatives: Design, Synthesis, Inhibitory Activity and Selectivity. Journal of Medicinal Chemistry. PMID 30216063 DOI: 10.1021/Acs.Jmedchem.8B00907 |
0.617 |
|
| 2018 |
Li T, Maltais R, Poirier D, Lin SX. Combined Biophysical Chemistry Reveals the Finding of a New Covalent Inhibitor with a Low-Reactive Alkyl Halide. The Journal of Physical Chemistry Letters. PMID 30148957 DOI: 10.1021/acs.jpclett.8b02225 |
0.613 |
|
| 2018 |
Perreault M, Maltais R, Roy J, Picard S, Popa I, Bertrand N, Poirier D. Induction of endoplasmic reticulum stress by aminosteroid derivative RM-581 leads to tumor regression in PANC-1 xenograft model. Investigational New Drugs. PMID 30062573 DOI: 10.1007/S10637-018-0643-4 |
0.561 |
|
| 2018 |
Dutour R, Maltais R, Perreault M, Roy J, Poirier D. Parallel Solid-Phase Synthesis Using a New Diethylsilylacetylenic Linker and Leading to Mestranol Derivatives with Potent Antiproliferative Activities on Multiple Cancer Cell Lines. Anti-Cancer Agents in Medicinal Chemistry. PMID 29521249 DOI: 10.2174/1871520618666180307130158 |
0.577 |
|
| 2018 |
Li T, Maltais R, Poirier D, Lin S. Combined Biophysical Chemistry Reveals a New Covalent Inhibitor with a Low-Reactivity Alkyl Halide Journal of Physical Chemistry Letters. 9: 5275-5280. DOI: 10.2210/Pdb6Cge/Pdb |
0.648 |
|
| 2017 |
Perreault M, Maltais R, Kenmogne LC, Létourneau D, LeHoux JG, Gobeil S, Poirier D. Implication of STARD5 and cholesterol homeostasis disturbance in the endoplasmic reticulum stress-related response induced by pro-apoptotic aminosteroid RM-133. Pharmacological Research. PMID 29287690 DOI: 10.1016/J.Phrs.2017.12.024 |
0.537 |
|
| 2017 |
Maltais R, Trottier A, Roy J, Ayan D, Bertrand N, Poirier D. Pharmacokinetic profile of PBRM in rodents, a first selective covalent inhibitor of 17β-HSD1 for breast cancer and endometriosis treatments. The Journal of Steroid Biochemistry and Molecular Biology. PMID 29248731 DOI: 10.1016/J.Jsbmb.2017.12.007 |
0.619 |
|
| 2017 |
Trottier A, Maltais R, Ayan D, Barbeau X, Roy J, Perreault M, Poulin R, Lagüe P, Poirier D. Insight into the mode of action and selectivity of PBRM, a covalent steroidal inhibitor of 17β-hydroxysteroid dehydrogenase type 1. Biochemical Pharmacology. PMID 28800957 DOI: 10.1016/J.Bcp.2017.08.004 |
0.661 |
|
| 2017 |
Cortés-Benítez F, Roy J, Maltais R, Poirier D. Impact of androstane A- and D-ring inversion on 17β-hydroxysteroid dehydrogenase type 3 inhibitory activity, androgenic effect and metabolic stability. Bioorganic & Medicinal Chemistry. PMID 28254377 DOI: 10.1016/J.Bmc.2017.02.008 |
0.646 |
|
| 2017 |
Kenmogne LC, Roy J, Maltais R, Rouleau M, Neveu B, Pouliot F, Poirier D. Investigation of the In Vitro and In Vivo efficiency of RM-532-105, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, in LAPC-4 prostate cancer cell and tumor models. Plos One. 12: e0171871. PMID 28182747 DOI: 10.1371/Journal.Pone.0171871 |
0.66 |
|
| 2017 |
Perreault M, Maltais R, Roy J, Dutour R, Poirier D. Design of a Mestranol 2-N-Piperazino-Substituted Derivative Showing Potent and Selective in vitro and in vivo Activities in MCF-7 Breast Cancer Models. Chemmedchem. PMID 28060448 DOI: 10.1002/Cmdc.201600482 |
0.63 |
|
| 2017 |
Poirier D, Maltais R. NMR-Assisted Structure Elucidation of an Anticancer Steroid-β-Enaminone Derivative Magnetochemistry. 3: 37. DOI: 10.3390/Magnetochemistry3040037 |
0.617 |
|
| 2016 |
Perreault M, Maltais R, Dutour R, Poirier D. Explorative study on the anticancer activity, selectivity and metabolic stability of related analogs of aminosteroid RM-133. Steroids. PMID 27553727 DOI: 10.1016/J.Steroids.2016.08.015 |
0.621 |
|
| 2016 |
Ouellet C, Maltais R, Ouellet É, Barbeau X, Lagüe P, Poirier D. Discovery of a sulfamate-based steroid sulfatase inhibitor with intrinsic selective estrogen receptor modulator properties. European Journal of Medicinal Chemistry. 119: 169-182. PMID 27155470 DOI: 10.1016/J.Ejmech.2016.04.044 |
0.641 |
|
| 2016 |
Kenmogne LC, Maltais R, Poirier D. Synthesis of a dansyl-labeled inhibitor of 17β-hydroxysteroid dehydrogenase type 3 for optical imaging. Bioorganic & Medicinal Chemistry Letters. 26: 2179-83. PMID 27025340 DOI: 10.1016/J.Bmcl.2016.03.069 |
0.659 |
|
| 2015 |
Talbot A, Maltais R, Kenmogne LC, Roy J, Poirier D. Solid-phase synthesis of libraries of ethynylated aminosteroid derivatives as potential antileukemic agents. Steroids. PMID 26742630 DOI: 10.1016/J.Steroids.2015.12.019 |
0.612 |
|
| 2015 |
Kenmogne LC, Ayan D, Roy J, Maltais R, Poirier D. The Aminosteroid Derivative RM-133 Shows In Vitro and In Vivo Antitumor Activity in Human Ovarian and Pancreatic Cancers. Plos One. 10: e0144890. PMID 26660672 DOI: 10.1371/Journal.Pone.0144890 |
0.552 |
|
| 2015 |
Maltais R, Trottier A, Barbeau X, Lagüe P, Perreault M, Thériault JF, Lin SX, Poirier D. Impact of structural modifications at positions 13, 16 and 17 of 16β-(m-carbamoylbenzyl)-estradiol on 17β-hydroxysteroid dehydrogenase type 1 inhibition and estrogenic activity. The Journal of Steroid Biochemistry and Molecular Biology. PMID 26519987 DOI: 10.1016/J.Jsbmb.2015.10.020 |
0.642 |
|
| 2015 |
Roy J, Fournier MA, Maltais R, Kenmogne LC, Poirier D. Reprint of "In vitro and in vivo evaluation of a 3β-androsterone derivative as inhibitor of 17β-hydroxysteroid dehydrogenase type 3". The Journal of Steroid Biochemistry and Molecular Biology. 153: 170-8. PMID 26291835 DOI: 10.1016/J.Jsbmb.2015.08.014 |
0.65 |
|
| 2015 |
Djigoué GB, Kenmogne LC, Roy J, Maltais R, Poirier D. Design, chemical synthesis and biological evaluation of 3-spiromorpholinone/3-spirocarbamate androsterone derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 3. Bioorganic & Medicinal Chemistry. 23: 5433-51. PMID 26277760 DOI: 10.1016/J.Bmc.2015.07.049 |
0.686 |
|
| 2015 |
Maltais R, Trottier A, Delhomme A, Barbeau X, Lagüe P, Poirier D. Identification of fused 16β,17β-oxazinone-estradiol derivatives as a new family of non-estrogenic 17β-hydroxysteroid dehydrogenase type 1 inhibitors. European Journal of Medicinal Chemistry. 93: 470-80. PMID 25728028 DOI: 10.1016/J.Ejmech.2015.01.059 |
0.662 |
|
| 2015 |
Poirier D, Roy J, Maltais R, Ayan D. A Potent Inhibitor of Steroid Sulfatase (EM-1913) Blocks Tumor Growth in Nude Mice (MCF-7 Xenograft) Current Enzyme Inhibition. 11: 65-73. DOI: 10.2174/157340801101150707124626 |
0.487 |
|
| 2014 |
Ayan D, Maltais R, Hospital A, Poirier D. Chemical synthesis, cytotoxicity, selectivity and bioavailability of 5α-androstane-3α,17β-diol derivatives. Bioorganic & Medicinal Chemistry. 22: 5847-59. PMID 25300820 DOI: 10.1016/J.Bmc.2014.09.026 |
0.658 |
|
| 2014 |
Djigoué GB, Maltais R, Poirier D. Development of a simple and efficient solution-phase parallel synthesis of flexible non-steroidal estradiol mimics. Combinatorial Chemistry & High Throughput Screening. 17: 734-44. PMID 25230027 DOI: 10.2174/1386207317666140915125620 |
0.585 |
|
| 2014 |
Trottier A, Maltais R, Poirier D. Identification of a first enzymatic activator of a 17β-hydroxysteroid dehydrogenase. Acs Chemical Biology. 9: 1668-73. PMID 24910887 DOI: 10.1021/Cb500109E |
0.637 |
|
| 2014 |
Maltais R, Hospital A, Delhomme A, Roy J, Poirier D. Chemical synthesis, NMR analysis and evaluation on a cancer xenograft model (HL-60) of the aminosteroid derivative RM-133. Steroids. 82: 68-76. PMID 24486462 DOI: 10.1016/J.Steroids.2014.01.008 |
0.596 |
|
| 2014 |
Roy J, Fournier MA, Maltais R, Kenmogne LC, Poirier D. In vitro and in vivo evaluation of a 3β-androsterone derivative as inhibitor of 17β-hydroxysteroid dehydrogenase type 3. The Journal of Steroid Biochemistry and Molecular Biology. 141: 44-51. PMID 24434282 DOI: 10.1016/j.jsbmb.2013.12.019 |
0.611 |
|
| 2014 |
Maltais R, Ayan D, Trottier A, Barbeau X, Lagüe P, Bouchard JE, Poirier D. Discovery of a non-estrogenic irreversible inhibitor of 17β-hydroxysteroid dehydrogenase type 1 from 3-substituted-16β-(m-carbamoylbenzyl)-estradiol derivatives. Journal of Medicinal Chemistry. 57: 204-22. PMID 24328103 DOI: 10.1021/Jm401639V |
0.673 |
|
| 2014 |
Talbot A, Maltais R, Poirier D. Synthesis of an estradiol derivative with an adenosine-phosphate mimic linked at position 16β Current Organic Synthesis. 11: 612-620. DOI: 10.2174/15701794113106660078 |
0.648 |
|
| 2013 |
Roy J, Lefebvre J, Maltais R, Poirier D. Inhibition of dehydroepiandosterone sulfate action in androgen-sensitive tissues by EM-1913, an inhibitor of steroid sulfatase Molecular and Cellular Endocrinology. 376: 148-155. PMID 23806558 DOI: 10.1016/J.Mce.2013.06.022 |
0.572 |
|
| 2013 |
Ajeawung NF, Maltais R, Jones C, Poirier D, Kamnasaran D. Viability screen on pediatric low grade glioma cell lines unveils a novel anti-cancer drug of the steroid biosynthesis inhibitor family. Cancer Letters. 330: 96-105. PMID 23201138 DOI: 10.1016/J.Canlet.2012.11.034 |
0.584 |
|
| 2013 |
Ouellet É, Maltais R, Ouellet C, Poirier D. Investigation of a tetrahydroisoquinoline scaffold as dual-action steroid sulfatase inhibitors generated by parallel solid-phase synthesis Medchemcomm. 4: 681. DOI: 10.1039/C3Md20354A |
0.644 |
|
| 2012 |
Ayan D, Maltais R, Roy J, Poirier D. A new nonestrogenic steroidal inhibitor of 17β-hydroxysteroid dehydrogenase type I blocks the estrogen-dependent breast cancer tumor growth induced by estrone. Molecular Cancer Therapeutics. 11: 2096-104. PMID 22914440 DOI: 10.1158/1535-7163.Mct-12-0299 |
0.657 |
|
| 2012 |
Jegham H, Maltais R, Dufour P, Roy J, Poirier D. Solid-phase chemical synthesis and in vitro biological evaluation of novel 2β-piperazino-(20R)-5α-pregnane-3α,20-diol N-derivatives as anti-leukemic agents. Steroids. 77: 1403-18. PMID 22910290 DOI: 10.1016/J.Steroids.2012.07.012 |
0.653 |
|
| 2012 |
Ayan D, Maltais R, Poirier D. Identification of a 17β-hydroxysteroid dehydrogenase type 10 steroidal inhibitor: a tool to investigate the role of type 10 in Alzheimer's disease and prostate cancer. Chemmedchem. 7: 1181-4. PMID 22674910 DOI: 10.1002/Cmdc.201200129 |
0.589 |
|
| 2012 |
Talbot A, Maltais R, Poirier D. New diethylsilylacetylenic linker for parallel solid-phase synthesis of libraries of hydroxy acetylenic steroid derivatives with improved metabolic stability. Acs Combinatorial Science. 14: 347-51. PMID 22587990 DOI: 10.1021/Co300034Y |
0.586 |
|
| 2012 |
Jegham H, Maltais R, Roy J, Doillon C, Poirier D. Biological evaluation of a new family of aminosteroids that display a selective toxicity for various malignant cell lines. Anti-Cancer Drugs. 23: 803-14. PMID 22361842 DOI: 10.1097/Cad.0B013E328351Aa8C |
0.58 |
|
| 2012 |
Jegham H, Roy J, Maltais R, Desnoyers S, Poirier D. A novel aminosteroid of the 5α-androstane-3α,17β-diol family induces cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells. Investigational New Drugs. 30: 176-85. PMID 20890632 DOI: 10.1007/S10637-010-9548-6 |
0.553 |
|
| 2012 |
Djigoué GB, Maltais R, Ouellet C, Trottier A, Poirier D. Chemical Synthesis and NMR Characterization of Non Steroidal Mimics of an Estradiol Derivative Used as Inhibitor of 17beta-Hydroxysteroid Dehydrogenase Type 1 International Journal of Chemistry. 4. DOI: 10.5539/Ijc.V4N6P75 |
0.646 |
|
| 2012 |
Poirier D, Ajeawung N, Maltais R, Kamnasaran D. 341 Cytotoxic Screen Unveils a Novel Inhibitor of Low Grade Pediatric Astrocytomas Belonging to a Family of Steroid Inhibitor Compounds European Journal of Cancer. 48: 104. DOI: 10.1016/S0959-8049(12)72139-1 |
0.528 |
|
| 2012 |
Maltais R, Poirier D. Diversity-oriented synthesis of spiro-and fused azacycles from ketone molecular templates European Journal of Organic Chemistry. 5435-5439. DOI: 10.1002/Ejoc.201200852 |
0.607 |
|
| 2011 |
Maltais R, Ayan D, Poirier D. Crucial Role of 3-Bromoethyl in Removing the Estrogenic Activity of 17β-HSD1 Inhibitor 16β-(m-Carbamoylbenzyl)estradiol. Acs Medicinal Chemistry Letters. 2: 678-681. PMID 21927646 DOI: 10.1021/Ml200093V |
0.664 |
|
| 2011 |
Ayan D, Roy J, Maltais R, Poirier D. Impact of estradiol structural modifications (18-methyl and/or 17-hydroxy inversion of configuration) on the in vitro and in vivo estrogenic activity. The Journal of Steroid Biochemistry and Molecular Biology. 127: 324-30. PMID 21827856 DOI: 10.1016/J.Jsbmb.2011.07.009 |
0.641 |
|
| 2011 |
Maltais R, Fournier MA, Poirier D. Development of 3-substituted-androsterone derivatives as potent inhibitors of 17β-hydroxysteroid dehydrogenase type 3. Bioorganic & Medicinal Chemistry. 19: 4652-68. PMID 21741247 DOI: 10.1016/J.Bmc.2011.06.003 |
0.688 |
|
| 2011 |
Maltais R, Poirier D. Steroid sulfatase inhibitors: a review covering the promising 2000-2010 decade. Steroids. 76: 929-48. PMID 21458474 DOI: 10.1016/J.Steroids.2011.03.010 |
0.582 |
|
| 2011 |
Roy J, Maltais R, Jegham H, Poirier D. Libraries of 2β-(N-substituted piperazino)-5α-androstane-3α, 17β-diols: chemical synthesis and cytotoxic effects on human leukemia HL-60 cells and on normal lymphocytes. Molecular Diversity. 15: 317-39. PMID 20827507 DOI: 10.1007/S11030-010-9273-2 |
0.636 |
|
| 2011 |
Farhane S, Fournier M, Maltais R, Poirier D. Convergent stereoselective and efficient synthesis of furanic-steroid derivatives Tetrahedron. 67: 2434-2440. DOI: 10.1016/J.Tet.2011.01.083 |
0.641 |
|
| 2010 |
MALTAIS R, POIRIER D. ChemInform Abstract: A Solution-Phase Combinatorial Parallel Synthesis of 3β-Amido-3α-hydroxy-5α-androstane-17-ones. Cheminform. 29: no-no. DOI: 10.1002/chin.199833234 |
0.548 |
|
| 2009 |
Maltais R, Fournier D, Poirier D. Quantitative structure-activity relationship (QSAR) study with a series of 17α-derivatives of estradiol: Model for the development of reversible steroid sulfatase inhibitors Qsar and Combinatorial Science. 28: 1284-1299. DOI: 10.1002/Qsar.200960028 |
0.627 |
|
| 2006 |
Poirier D, Maltais R. Solid-phase organic synthesis (SPOS) of modulators of estrogenic and androgenic action. Mini Reviews in Medicinal Chemistry. 6: 37-52. PMID 16457631 DOI: 10.2174/138955706775197802 |
0.594 |
|
| 2005 |
Maltais R, Mercier C, Labrie F, Poirier D. Solid-phase synthesis of model libraries of 3alpha,17beta-dihydroxy-16alpha-(aminoethyl-N-substituted)-5alpha-androstanes for the development of steroidal therapeutic agents. Molecular Diversity. 9: 67-79. PMID 15789554 DOI: 10.1007/S11030-005-1312-Z |
0.543 |
|
| 2004 |
Maltais R, Tremblay MR, Ciobanu LC, Poirier D. Steroids and combinatorial chemistry. Journal of Combinatorial Chemistry. 6: 443-56. PMID 15244402 DOI: 10.1021/Cc030118M |
0.757 |
|
| 2002 |
Maltais R, Luu-The V, Poirier D. Synthesis and optimization of a new family of type 3 17 beta-hydroxysteroid dehydrogenase inhibitors by parallel liquid-phase chemistry. Journal of Medicinal Chemistry. 45: 640-53. PMID 11806715 DOI: 10.1021/Jm010286Y |
0.572 |
|
| 2001 |
Maltais R, Luu-The V, Poirier D. Parallel solid-phase synthesis of 3β-peptido-3α-hydroxy-5α-androstan-17-one derivatives for inhibition of Type 3 17β-hydroxysteroid dehydrogenase Bioorganic and Medicinal Chemistry. 9: 3101-3111. PMID 11711285 DOI: 10.1016/S0968-0896(01)00182-1 |
0.675 |
|
| 2000 |
Maltais R, Tremblay MR, Poirier D. Solid-phase synthesis of hydroxysteroid derivatives using the diethylsilyloxy linker Journal of Combinatorial Chemistry. 2: 604-614. PMID 11126290 DOI: 10.1021/Cc0000242 |
0.604 |
|
| 2000 |
Ciobanu LC, Maltais R, Poirier D. The sulfamate functional group as a new anchor for solid-phase organic synthesis Organic Letters. 2: 445-8. PMID 10814347 DOI: 10.1021/Ol990381P |
0.754 |
|
| 2000 |
Maltais R, Bérubé M, Marion O, Labrecque R, Poirier D. Efficient coupling and solid-phase synthesis of steroidal ketone derivative using polymer-bound glycerol Tetrahedron Letters. 41: 1691-1694. DOI: 10.1016/S0040-4039(00)00050-2 |
0.546 |
|
| 1999 |
Poirier D, Ciobanu LC, Maltais R. Steroid sulfatase inhibitors Expert Opinion On Therapeutic Patents. 9: 1083-1099. DOI: 10.1517/13543776.9.8.1083 |
0.772 |
|
| 1998 |
Maltais R, Poirier D. A solution-phase combinatorial parallel synthesis of 3β-amido-3α- hydroxy 5α-androstane-17-ones Tetrahedron Letters. 39: 4151-4154. DOI: 10.1016/S0040-4039(98)00772-2 |
0.633 |
|
| Show low-probability matches. |