Rene Maltais, Ph.D. - Related publications

2001 Universite Laval (Canada) 
Pharmaceutical Chemistry
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 El-Sattar NEAA, Badawy EHK, AbdEl-Hady WH, Abo-Alkasem MI, Mandour AA, Ismail NSM. Design and Synthesis of New CDK2 Inhibitors Containing Thiazolone and Thiazolthione Scafold with Apoptotic Activity. Chemical & Pharmaceutical Bulletin. 69: 106-117. PMID 33390512 DOI: 10.1248/cpb.c20-00714   
2021 Hu J, Zhang Y, Tang N, Lu Y, Guo P, Huang Z. Discovery of novel 1,3,5-triazine derivatives as potent inhibitor of cervical cancer via dual inhibition of PI3K/mTOR. Bioorganic & Medicinal Chemistry. 32: 115997. PMID 33440319 DOI: 10.1016/j.bmc.2021.115997   
2021 Hu J, Zhang Y, Tang N, Lu Y, Guo P, Huang Z. Discovery of novel 1,3,5-triazine derivatives as potent inhibitor of cervical cancer via dual inhibition of PI3K/mTOR. Bioorganic & Medicinal Chemistry. 32: 115997. PMID 33440319 DOI: 10.1016/j.bmc.2021.115997   
2021 Nagy MI, Darwish KM, Kishk SM, Tantawy MA, Nasr AM, Qushawy M, Swidan SA, Mostafa SM, Salama I. Design, Synthesis, Anticancer Activity, and Solid Lipid Nanoparticle Formulation of Indole- and Benzimidazole-Based Compounds as Pro-Apoptotic Agents Targeting Bcl-2 Protein. Pharmaceuticals (Basel, Switzerland). 14. PMID 33535550 DOI: 10.3390/ph14020113   
2021 Villena J, Montenegro I, Said B, Werner E, Flores S, Madrid A. Ultrasound assisted synthesis and cytotoxicity evaluation of known 2',4'-dihydroxychalcone derivatives against cancer cell lines. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 148: 111969. PMID 33421463 DOI: 10.1016/j.fct.2021.111969   
2021 Elhady SS, Abdelhameed RFA, El-Ayouty MM, Ibrahim AK, Habib ES, Elgawish MS, Hassanean HA, Safo MK, Nafie MS, Ahmed SA. New Antiproliferative Triflavanone from -Isolation, Structure Elucidation and Molecular Docking Studies. Molecules (Basel, Switzerland). 26. PMID 33572651 DOI: 10.3390/molecules26030739   
2021 Zhang J, Chen P, Duan Y, Xiong H, Li H, Zeng Y, Liang G, Tang Q, Wu D. Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidine derivatives containing 1,8-naphthyridine-4-one fragment. European Journal of Medicinal Chemistry. 215: 113273. PMID 33601310 DOI: 10.1016/j.ejmech.2021.113273   
2021 Hao EJ, Li GX, Liang YR, Xie MS, Wang DC, Jiang XH, Cheng JY, Shi ZX, Wang Y, Guo HM. Design, Synthesis, and Activity Evaluation of Novel Acyclic Nucleosides as Potential Anticancer Agents and . Journal of Medicinal Chemistry. PMID 33538581 DOI: 10.1021/acs.jmedchem.0c01717   
2021 Ghorab MM, Abdel-Kader MS, Alqahtani AS, Soliman AM. Synthesis of some quinazolinones inspired from the natural alkaloid Lnorephedrine as EGFR inhibitors and radiosensitizers. Journal of Enzyme Inhibition and Medicinal Chemistry. 36: 218-237. PMID 33357002 DOI: 10.1080/14756366.2020.1854243   
2021 Qin J, Qu S, Zhu K, Cheng Y, Pan G, Jing W, Liu X, Sun X, Liu L. Rational design and synthesis of 6-aryl-6H-benzo[c]chromenes as non-steroidal progesterone receptor antagonists for use against cancers. Bioorganic & Medicinal Chemistry. 32: 116003. PMID 33461148 DOI: 10.1016/j.bmc.2021.116003   
2021 Anh DT, Hai PT, Huy LD, Ngoc HB, Ngoc TTM, Dung DTM, Park EJ, Song IK, Kang JS, Kwon JH, Tung TT, Han SB, Nam NH. Novel 4-Oxoquinazoline-Based -Hydroxypropenamides as Histone Deacetylase Inhibitors: Design, Synthesis, and Biological Evaluation. Acs Omega. 6: 4907-4920. PMID 33644598 DOI: 10.1021/acsomega.0c05870   
2021 El Azab IH, El-Sheshtawy HS, Bakr RB, Elkanzi NAA. New 1,2,3-Triazole-Containing Hybrids as Antitumor Candidates: Design, Click Reaction Synthesis, DFT Calculations, and Molecular Docking Study. Molecules (Basel, Switzerland). 26. PMID 33573040 DOI: 10.3390/molecules26030708   
2021 Andima M, Ndakala A, Derese S, Biswajyoti S, Hussain A, Yang LJ, Akoth OE, Coghi P, Pal C, Heydenreich M, Wong VK, Yenesew A. Antileishmanial and cytotoxic activity of secondary metabolites from and two species. Natural Product Research. 1-5. PMID 33459049 DOI: 10.1080/14786419.2021.1871906   
2021 Voloshina AD, Sapunova AS, Kulik NV, Belenok MG, Strobykina IY, Lyubina AP, Gumerova SK, Kataev VE. Antimicrobial and cytotoxic effects of ammonium derivatives of diterpenoids steviol and isosteviol. Bioorganic & Medicinal Chemistry. 32: 115974. PMID 33461146 DOI: 10.1016/j.bmc.2020.115974   
2021 Das A, Kumar S, Persoons L, Daelemans D, Schols D, Alici H, Tahtaci H, Karki SS. Synthesis, in silico ADME, molecular docking and in vitro cytotoxicity evaluation of stilbene linked 1,2,3-triazoles. Heliyon. 7: e05893. PMID 33553718 DOI: 10.1016/j.heliyon.2020.e05893   
2021 Damghani T, Moosavi F, Khoshneviszadeh M, Mortazavi M, Pirhadi S, Kayani Z, Saso L, Edraki N, Firuzi O. Imidazopyridine hydrazone derivatives exert antiproliferative effect on lung and pancreatic cancer cells and potentially inhibit receptor tyrosine kinases including c-Met. Scientific Reports. 11: 3644. PMID 33574356 DOI: 10.1038/s41598-021-83069-4   
2021 Zhang Y, Yu H, Fu S, Tan L, Liu J, Zhou B, Li L, Liu Y, Wang C, Li P, Liu J. Synthesis and Anti-Hepatocarcinoma Effect of Amino Acid Derivatives of Pyxinol and Ocotillol. Molecules (Basel, Switzerland). 26. PMID 33546225 DOI: 10.3390/molecules26040780   
2021 Giang Nguyen Thi Q, Le-Nhat-Thuy G, Anh Dang Thi T, Hoang Thi P, Nguyen Tuan A, Ha Nguyen Thi T, Tra Nguyen T, Nguyen Ha T, Hoang Mai H, Van Nguyen T. Synthesis Of Novel Potent Cytotoxicy Podophyllotoxin-Naphthoquinone Compounds via Microwave-Assited Multicomponent Domino Reactions. Bioorganic & Medicinal Chemistry Letters. 127841. PMID 33556568 DOI: 10.1016/j.bmcl.2021.127841   
2021 Liu Q, Liu Z, Hua W, Gou S. Discovery of 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol Derivatives as Glutathione Transferase Inhibitors with Favorable Selectivity and Tolerated Toxicity. Journal of Medicinal Chemistry. PMID 33529017 DOI: 10.1021/acs.jmedchem.0c02048   
2021 Luan S, Gao Y, Liang X, Zhang L, Yin L, He C, Liu S, Yin Z, Yue G, Zou Y, Li L, Song X, Lv C, Zhang W, Jing B. Synthesis and structure-activity relationship of lipo-diterpenoid alkaloids with potential target of topoisomerase IIα for breast cancer treatment. Bioorganic Chemistry. 109: 104699. PMID 33611138 DOI: 10.1016/j.bioorg.2021.104699   
2021 Chrobak E, Jastrzębska M, Bębenek E, Kadela-Tomanek M, Marciniec K, Latocha M, Wrzalik R, Kusz J, Boryczka S. Molecular Structure, In Vitro Anticancer Study and Molecular Docking of New Phosphate Derivatives of Betulin. Molecules (Basel, Switzerland). 26. PMID 33572631 DOI: 10.3390/molecules26030737   
2021 Hagras M, El Deeb MA, Elzahabi HSA, Elkaeed EB, Mehany ABM, Eissa IH. Discovery of new quinolines as potent colchicine binding site inhibitors: design, synthesis, docking studies, and anti-proliferative evaluation. Journal of Enzyme Inhibition and Medicinal Chemistry. 36: 640-658. PMID 33588683 DOI: 10.1080/14756366.2021.1883598   
2021 Singh A, Chang TY, Kaur N, Hsu KC, Yen Y, Lin TE, Lai MJ, Lee SB, Liou JP. CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition. European Journal of Medicinal Chemistry. 215: 113169. PMID 33588178 DOI: 10.1016/j.ejmech.2021.113169   
2021 Chang X, Sun D, Shi D, Wang G, Chen Y, Zhang K, Tan H, Liu J, Liu B, Ouyang L. Design, synthesis, and biological evaluation of quinazolin-4(3)-one derivatives co-targeting poly(ADP-ribose) polymerase-1 and bromodomain containing protein 4 for breast cancer therapy. Acta Pharmaceutica Sinica. B. 11: 156-180. PMID 33532187 DOI: 10.1016/j.apsb.2020.06.003   
2021 Jin F, Hu Q, Fei H, Lv H, Wang S, Gui B, Zhang J, Tu W, Zhang Y, Zhang L, Wan H, Zhang L, Hu B, Yang F, Bai C, et al. Discovery of Hydroxyamidine Derivatives as Highly Potent, Selective Indoleamine-2,3-dioxygenase 1 Inhibitors. Acs Medicinal Chemistry Letters. 12: 195-201. PMID 33603965 DOI: 10.1021/acsmedchemlett.0c00443   
2021 Zhang J, Tan Y, Li G, Chen L, Nie M, Wang Z, Ji H. Coumarin Sulfonamides and Amides Derivatives: Design, Synthesis, and Antitumor Activity In Vitro. Molecules (Basel, Switzerland). 26. PMID 33546294 DOI: 10.3390/molecules26040786   
2021 Zhou BD, Wei RR, Li JL, Yu ZH, Weng ZM, Ruan ZP, Lin J, Fang YY, Xu GF, Hu DB. Synthesis and antitumor activity of benzophenone compound. Journal of Asian Natural Products Research. 1-9. PMID 33583279 DOI: 10.1080/10286020.2021.1886090   
2021 Chen T, Yang P, Chen HJ, Huang B. A new biflavonoids from induced non-apoptotic cell death in A549 cells. Natural Product Research. 1-7. PMID 33615932 DOI: 10.1080/14786419.2021.1882456   
2021 Chan PF, Ang KP, Hamid RA. A bismuth diethyldithiocarbamate compound induced apoptosis via mitochondria-dependent pathway and suppressed invasion in MCF-7 breast cancer cells. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. PMID 33555494 DOI: 10.1007/s10534-021-00286-0   
2021 Yan W, Zhang L, Lv F, Moccia M, Carlomagno F, Landry C, Santoro M, Gosselet F, Frett B, Li HY. Discovery of pyrazolo-thieno[3,2-d]pyrimidinylamino-phenyl acetamides as type-II pan-tropomyosin receptor kinase (TRK) inhibitors: Design, synthesis, and biological evaluation. European Journal of Medicinal Chemistry. 216: 113265. PMID 33652352 DOI: 10.1016/j.ejmech.2021.113265   
2021 Wang WY, Wu WY, Li AL, Liu QS, Sun Y, Gu W. Synthesis, anticancer evaluation and mechanism studies of novel indolequinone derivatives of ursolic acid. Bioorganic Chemistry. 109: 104705. PMID 33618252 DOI: 10.1016/j.bioorg.2021.104705   
2021 Zhong Y, Liu J, Cheng X, Zhang H, Zhang C, Xia Z, Wu Z, Zhang L, Zheng Y, Gao Z, Jiang Z, Wang Z, Huang D, Lu Y, Jiang F. Design, synthesis and biological evaluations of diverse Michael acceptor-based phenazine hybrid molecules as TrxR1 inhibitors. Bioorganic Chemistry. 109: 104736. PMID 33640630 DOI: 10.1016/j.bioorg.2021.104736   
2021 Lu X, Teng Y, Lin X, Xiao M, Liu C, Chi X, Zhang Y, Luo G, Xiang H. Discovery of novel 2H-chromene-3-carbonyl derivatives as selective estrogen receptor degraders (SERDs): Design, synthesis and biological evaluation. Bioorganic Chemistry. 109: 104714. PMID 33618254 DOI: 10.1016/j.bioorg.2021.104714   
2021 Machalz D, Li H, Du W, Sharma S, Liu S, Bureik M, Wolber G. Discovery of a novel potent cytochrome P450 CYP4Z1 inhibitor. European Journal of Medicinal Chemistry. 215: 113255. PMID 33611185 DOI: 10.1016/j.ejmech.2021.113255   
2021 You CX, Zhang K, Li X, Liu J, Zhang WJ, Yu XX. Cytotoxic Flavonoids from the Leaves and Twigs of . Molecules (Basel, Switzerland). 26. PMID 33652969 DOI: 10.3390/molecules26051284   
2021 Xu QQ, Zhang C, Zhang YL, Lei JL, Kong LY, Luo JG. Dimeric guaianes from leaves of Xylopia vielana as snail inhibitors identified by high content screening. Bioorganic Chemistry. 108: 104646. PMID 33484941 DOI: 10.1016/j.bioorg.2021.104646   
2021 Li J, Zhang W, Qiu Q, Zhou D, Feng Z, Tong Z, Wei J, Huang W, Li J, Qian H, Shi W. Design, synthesis and biological evaluation of novel 4,4-difluoro-1-methyl-N, 6-diphenyl-5, 6-dihydro-4H-pyrimido [4, 5-b] [1, 2, 4] triazolo [4, 3-d] [1, 4] diazepin-8-amine derivatives as potential BRD4 inhibitors. Chemical Biology & Drug Design. PMID 33638254 DOI: 10.1111/cbdd.13833   
2021 Lawal B, Liu YL, Mokgautsi N, Khedkar H, Sumitra MR, Wu ATH, Huang HS. Pharmacoinformatics and Preclinical Studies of NSC765690 and NSC765599, Potential STAT3/CDK2/4/6 Inhibitors with Antitumor Activities against NCI60 Human Tumor Cell Lines. Biomedicines. 9. PMID 33477856 DOI: 10.3390/biomedicines9010092   
2021 Mainasara MM, Abu Bakar MF, Md Akim A, Linatoc AC, Abu Bakar FI, Ranneh YKH. Secondary Metabolites, Antioxidant, and Antiproliferative Activities of Leaf Collected from Endau Rompin, Johor, Malaysia. Evidence-Based Complementary and Alternative Medicine : Ecam. 2021: 8826986. PMID 33505506 DOI: 10.1155/2021/8826986   
2021 Liang X, Tang S, Liu X, Liu Y, Xu Q, Wang X, Saidahmatov A, Li C, Wang J, Zhou Y, Zhang Y, Geng M, Huang M, Liu H. Discovery of Novel Pyrrolo[2,3-]pyrimidine-based Derivatives as Potent JAK/HDAC Dual Inhibitors for the Treatment of Refractory Solid Tumors. Journal of Medicinal Chemistry. PMID 33586434 DOI: 10.1021/acs.jmedchem.0c02111   
2021 Das V, Kaishap PP, Duarah G, Chikkaputtaiah C, Deka Boruah HP, Pal M. Cytotoxic and apoptosis-inducing effects of novel 8-amido isocoumarin derivatives against breast cancer cells. Naunyn-Schmiedeberg's Archives of Pharmacology. PMID 33649978 DOI: 10.1007/s00210-021-02063-9   
2021 Adnan M, Siddiqui AJ, Hamadou WS, Patel M, Ashraf SA, Jamal A, Awadelkareem AM, Sachidanandan M, Snoussi M, De Feo V. Phytochemistry, Bioactivities, Pharmacokinetics and Toxicity Prediction of with Its Anticancer Potential against Human Lung, Breast and Colorectal Carcinoma Cell Lines. Molecules (Basel, Switzerland). 26. PMID 33540783 DOI: 10.3390/molecules26030768   
2021 Abdelaal MR, Soror SH, Elnagar MR, Haffez H. Revealing the Potential Application of EC-Synthetic Retinoid Analogues in Anticancer Therapy. Molecules (Basel, Switzerland). 26. PMID 33477997 DOI: 10.3390/molecules26020506   
2021 Go RE, Kim CW, Lee SM, Lee HK, Choi KC. Fenhexamid induces cancer growth and survival via estrogen receptor-dependent and PI3K-dependent pathways in breast cancer models. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 112000. PMID 33484789 DOI: 10.1016/j.fct.2021.112000   
2021 van de Merbel AF, van Hooij O, van der Horst G, van Rijt-van de Westerlo CCM, van der Mark MH, Cheung H, Kroon J, Verhaegh GW, Tijhuis J, Wellink A, Maas P, Viëtor H, Schalken JA, van der Pluijm G. The Identification of Small Molecule Inhibitors That Reduce Invasion and Metastasis of Aggressive Cancers. International Journal of Molecular Sciences. 22. PMID 33567533 DOI: 10.3390/ijms22041688   
2021 Komuraiah B, Ren Y, Xue M, Cheng B, Liu J, Liu Y, Chen J. Design, Synthesis and Biological Evaluation of Benz-Fused Five-Membered Heterocyclic Compounds as Tubulin Polymerization Inhibitors with Anticancer Activities. Chemical Biology & Drug Design. PMID 33638903 DOI: 10.1111/cbdd.13832   
2021 Mokhir A, Xu H, Schikora M, Sisa M, Daum S, Janko C, Alexiou C, Bilyy R, Klemt I, Sellner L, Gong W, Schmitt M, Bila G. An endoplasmic reticulum - specific pro-amplifier of reactive oxygen species in cancer cells. Angewandte Chemie (International Ed. in English). PMID 33656236 DOI: 10.1002/anie.202100054   
2021 Zhou WX, Chen C, Liu XQ, Li Y, Kong LY, Luo JG. Synthesis and biological evaluation of novel withangulatin A derivatives as potential anticancer agents. Bioorganic Chemistry. 108: 104690. PMID 33592485 DOI: 10.1016/j.bioorg.2021.104690   
2021 Shakil MS, Parveen S, Rana Z, Walsh F, Movassaghi S, Söhnel T, Azam M, Shaheen MA, Jamieson SMF, Hanif M, Rosengren RJ, Hartinger CG. High Antiproliferative Activity of Hydroxythiopyridones over Hydroxypyridones and Their Organoruthenium Complexes. Biomedicines. 9. PMID 33513800 DOI: 10.3390/biomedicines9020123   
2021 Selas A, Martin-Encinas E, Fuertes M, Masdeu C, Rubiales G, Palacios F, Alonso C. A patent review of topoisomerase I inhibitors (2016-present). Expert Opinion On Therapeutic Patents. PMID 33475439 DOI: 10.1080/13543776.2021.1879051