Roselyne Castonguay, Ph.D. - Publications

2004 Université de Montréal, Montréal, Canada 
Organic Chemistry

22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Kumar R, Grinberg AV, Li H, Kuo TH, Sako D, Krishnan L, Liharska K, Li J, Grenha R, Maguire MC, Briscoe SD, Pearsall RS, Herrin BR, Suragani RNVS, Castonguay R. Functionally diverse heteromeric traps for ligands of the transforming growth factor-β superfamily. Scientific Reports. 11: 18341. PMID 34526551 DOI: 10.1038/s41598-021-97203-9  1
2021 Li J, Fredericks M, Cannell M, Wang K, Sako D, Maguire MC, Grenha R, Liharska K, Krishnan L, Bloom T, Belcheva EP, Martinez PA, Castonguay R, Keates S, Alexander MJ, et al. ActRIIB:ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders. The Journal of Clinical Investigation. 131. PMID 33586684 DOI: 10.1172/JCI138634  1
2020 Bu Y, Zhao M, Fredericks M, Cannell M, Dagon Y, Emdin CA, Okunishi K, Wang H, Sako D, Castonguay R, Suragani RNV, Kathiresan S, Grinberg A, Knopf J, Pearsall RS, et al. 1937-P: ALK-7: A Validated Target for the Treatment of Obesity Diabetes. 69. DOI: 10.2337/Db20-1937-P  1
2019 Pearsall RS, Davies MV, Cannell M, Li J, Widrick J, Mulivor AW, Wallner S, Troy ME, Spaits M, Liharska K, Sako D, Castonguay R, Keates S, Grinberg AV, Suragani RNVS, et al. Follistatin-based ligand trap ACE-083 induces localized hypertrophy of skeletal muscle with functional improvement in models of neuromuscular disease. Scientific Reports. 9: 11392. PMID 31388039 DOI: 10.1038/S41598-019-47818-W  1
2019 Goebel EJ, Corpina RA, Hinck CS, Czepnik M, Castonguay R, Grenha R, Boisvert A, Miklossy G, Fullerton PT, Matzuk MM, Idone VJ, Economides AN, Kumar R, Hinck AP, Thompson TB. Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity. Proceedings of the National Academy of Sciences of the United States of America. PMID 31315975 DOI: 10.2210/Pdb6Mac/Pdb  0.01
2018 Castonguay R, Lachey J, Wallner S, Strand J, Liharska K, Watanabe AE, Cannell M, Davies MV, Sako D, Troy ME, Krishnan L, Mulivor AW, Li H, Keates S, Alexander MJ, et al. Follistatin-288-Fc Fusion Protein Promotes Localized Growth of Skeletal Muscle. The Journal of Pharmacology and Experimental Therapeutics. PMID 30563942 DOI: 10.1124/Jpet.118.252304  1
2015 Pearsall R, Sako D, Liu J, Davies M, Heveron K, Castonguay R, Krishnan L, Troy M, Liharska K, Steeves R, Cannell M, Alimzhanov M, Grinberg A, Kumar R. ACE-2494, a novel GDF ligand trap, increases muscle and bone mass upon systemic administration in mice Neuromuscular Disorders. 25. DOI: 10.1016/J.Nmd.2015.06.122  1
2014 Mulivor A, Sako D, Cannell M, Wallner S, Hevron K, Steeves R, Castonguay R, Pearsall RS, Kumar R. G.P.205 Neuromuscular Disorders. 24: 878. DOI: 10.1016/J.Nmd.2014.06.281  1
2011 Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. The Journal of Biological Chemistry. 286: 30034-46. PMID 21737454 DOI: 10.1074/Jbc.M111.260133  1
2010 Guy J, Castonguay R, Campos-Reales Pineda NB, Jacquier V, Caron K, Michnick SW, Keillor JW. De novo helical peptides as target sequences for a specific, fluorogenic protein labelling strategy. Molecular Biosystems. 6: 976-87. PMID 20485742 DOI: 10.1039/B918205E  1
2010 Sako D, Grinberg AV, Liu J, Davies MV, Castonguay R, Maniatis S, Andreucci AJ, Pobre EG, Tomkinson KN, Monnell TE, Ucran JA, Martinez-Hackert E, Pearsall RS, Underwood KW, Seehra J, et al. Characterization of the ligand binding functionality of the extracellular domain of activin receptor type IIb. The Journal of Biological Chemistry. 285: 21037-48. PMID 20385559 DOI: 10.1074/Jbc.M110.114959  1
2010 Mitchell D, Pobre EG, Mulivor AW, Grinberg AV, Castonguay R, Monnell TE, Solban N, Ucran JA, Pearsall RS, Underwood KW, Seehra J, Kumar R. ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth. Molecular Cancer Therapeutics. 9: 379-88. PMID 20124460 DOI: 10.1158/1535-7163.Mct-09-0650  1
2009 Mitchell D, Pobre EG, Mulivor AW, Grinberg AV, Castonguay R, Monnell TE, Solban N, Ucran J, Pearsall RS, Underwood KW, Seehra J, Kumar R. Abstract B5: ACE‐041, a soluble activin receptor‐like kinase‐1 fusion protein, is a novel antiangiogenic agent Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-B5  1
2008 Castonguay R, Valenzano CR, Chen AY, Keatinge-Clay A, Khosla C, Cane DE. Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase. Journal of the American Chemical Society. 130: 11598-9. PMID 18693734 DOI: 10.1021/Ja804453P  1
2007 Castonguay R, Halim D, Morin M, Furtos A, Lherbet C, Bonneil E, Thibault P, Keillor JW. Kinetic characterization and identification of the acylation and glycosylation sites of recombinant human gamma-glutamyltranspeptidase. Biochemistry. 46: 12253-62. PMID 17924658 DOI: 10.1021/Bi700956C  1
2007 Castonguay R, He W, Chen AY, Khosla C, Cane DE. Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase. Journal of the American Chemical Society. 129: 13758-69. PMID 17918944 DOI: 10.1021/Ja0753290  1
2005 Keillor JW, Castonguay R, Lherbet C. Gamma-glutamyl transpeptidase substrate specificity and catalytic mechanism. Methods in Enzymology. 401: 449-67. PMID 16399402 DOI: 10.1016/S0076-6879(05)01027-X  1
2003 Castonguay R, Lherbet C, Keillor JW. Kinetic studies of rat kidney gamma-glutamyltranspeptidase deacylation reveal a general base-catalyzed mechanism. Biochemistry. 42: 11504-13. PMID 14516202 DOI: 10.1021/Bi035064B  1
2003 Lherbet C, Morin M, Castonguay R, Keillor JW. Synthesis of aza and oxaglutamyl-p-nitroanilide derivatives and their kinetic studies with gamma-glutamyltranspeptidase. Bioorganic & Medicinal Chemistry Letters. 13: 997-1000. PMID 12643897 DOI: 10.1016/S0960-894X(03)00083-0  1
2003 Keillor JW, Lherbet C, Castonguay R, Lapierre D, Martinez-Oyanedel J, Fothergill-Gilmore LA, Walkinshaw MD. Expression, purification, crystallization and preliminary crystallographic analysis of Trypanosoma brucei phosphofructokinase. Acta Crystallographica. Section D, Biological Crystallography. 59: 532-4. PMID 12595717 DOI: 10.1107/S0907444902023478  1
2002 Castonguay R, Lherbet C, Keillor JW. Mapping of the active site of rat kidney gamma-glutamyl transpeptidase using activated esters and their amide derivatives. Bioorganic & Medicinal Chemistry. 10: 4185-91. PMID 12413871 DOI: 10.1016/S0968-0896(02)00165-7  1
2001 Ménard A, Castonguay R, Lherbet C, Rivard C, Roupioz Y, Keillor JW. Nonlinear free energy relationship in the general-acid-catalyzed acylation of rat kidney gamma-glutamyl transpeptidase by a series of gamma-glutamyl anilide substrate analogues. Biochemistry. 40: 12678-85. PMID 11601992 DOI: 10.1021/Bi011234D  1
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