| Year |
Citation |
Score |
| 2022 |
Cao C, Barros-Álvarez X, Zhang S, Kim K, Dämgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Hüttenhain R, ... Nichols DE, et al. Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD. Neuron. PMID 36087581 DOI: 10.1016/j.neuron.2022.08.006 |
0.351 |
|
| 2022 |
Nichols CD, Nichols DE. Preface to the special issue "Psychedelics and Neurochemistry". Journal of Neurochemistry. PMID 35699130 DOI: 10.1111/jnc.15651 |
0.433 |
|
| 2020 |
Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, Wacker D, Robertson MJ, Seven AB, Nichols DE, Shoichet BK, Skiniotis G, Roth BL. Structure of a Hallucinogen-Activated Gq-Coupled 5-HT Serotonin Receptor. Cell. 182: 1574-1588.e19. PMID 32946782 DOI: 10.1016/J.Cell.2020.08.024 |
0.318 |
|
| 2019 |
Kuypers KP, Ng L, Erritzoe D, Knudsen GM, Nichols CD, Nichols DE, Soula A, Nutt D. Microdosing psychedelics: More questions than answers? An overview and suggestions for future research. Journal of Psychopharmacology (Oxford, England). 269881119857204. PMID 31303095 DOI: 10.1177/0269881119857204 |
0.419 |
|
| 2017 |
Kyzar EJ, Nichols CD, Gainetdinov RR, Nichols DE, Kalueff AV. Psychedelic Drugs in Biomedicine. Trends in Pharmacological Sciences. PMID 28947075 DOI: 10.1016/j.tips.2017.08.003 |
0.403 |
|
| 2017 |
Brandt SD, Kavanagh PV, Twamley B, Westphal F, Elliott SP, Wallach J, Stratford A, Klein LM, McCorvy JD, Nichols DE, Halberstadt AL. Return of the lysergamides. Part IV: Analytical and pharmacological characterization of lysergic acid morpholide (LSM-775). Drug Testing and Analysis. PMID 28585392 DOI: 10.1002/Dta.2222 |
0.649 |
|
| 2017 |
Hoehn RD, Nichols DE, McCorvy JD, Neven H, Kais S. Experimental evaluation of the generalized vibrational theory of G protein-coupled receptor activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28500275 DOI: 10.1073/Pnas.1618422114 |
0.693 |
|
| 2017 |
Nichols DE. Chemistry and Structure-Activity Relationships of Psychedelics. Current Topics in Behavioral Neurosciences. PMID 28401524 DOI: 10.1007/7854_2017_475 |
0.35 |
|
| 2017 |
Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, Lansu K, Schools ZL, Che T, Nichols DE, Shoichet BK, Dror RO, Roth BL. Crystal Structure of an LSD-Bound Human Serotonin Receptor. Cell. 168: 377-389.e12. PMID 28129538 DOI: 10.1016/J.Cell.2016.12.033 |
0.684 |
|
| 2016 |
Nichols DE, Johnson MW, Nichols CD. Psychedelics as Medicines: An Emerging New Paradigm. Clinical Pharmacology and Therapeutics. PMID 28019026 DOI: 10.1002/cpt.557 |
0.441 |
|
| 2015 |
Nichols DE, Sassano MF, Halberstadt AL, Klein LM, Brandt SD, Elliott SP, Fiedler WJ. N-Benzyl-5-methoxytryptamines as Potent Serotonin 5-HT2 Receptor Family Agonists and Comparison with a Series of Phenethylamine Analogues. Acs Chemical Neuroscience. 6: 1165-75. PMID 25547199 DOI: 10.1021/Cn500292D |
0.442 |
|
| 2014 |
Martin DA, Marona-Lewicka D, Nichols DE, Nichols CD. Chronic LSD alters gene expression profiles in the mPFC relevant to schizophrenia. Neuropharmacology. 83: 1-8. PMID 24704148 DOI: 10.1016/j.neuropharm.2014.03.013 |
0.444 |
|
| 2013 |
Juncosa JI, Hansen M, Bonner LA, Cueva JP, Maglathlin R, McCorvy JD, Marona-Lewicka D, Lill MA, Nichols DE. Extensive rigid analogue design maps the binding conformation of potent N-benzylphenethylamine 5-HT2A serotonin receptor agonist ligands. Acs Chemical Neuroscience. 4: 96-109. PMID 23336049 DOI: 10.1021/Cn3000668 |
0.836 |
|
| 2012 |
Pigott A, Frescas S, McCorvy JD, Huang XP, Roth BL, Nichols DE. trans-2-(2,5-Dimethoxy-4-iodophenyl)cyclopropylamine and trans-2-(2,5-dimethoxy-4-bromophenyl)cyclopropylamine as potent agonists for the 5-HT(2) receptor family. Beilstein Journal of Organic Chemistry. 8: 1705-9. PMID 23209503 DOI: 10.3762/Bjoc.8.194 |
0.752 |
|
| 2012 |
Clark AH, McCorvy JD, Conley JM, Williams WK, Bekkam M, Watts VJ, Nichols DE. Identification of a 2-phenyl-substituted octahydrobenzo[f]quinoline as a dopamine D₃ receptor-selective full agonist ligand. Bioorganic & Medicinal Chemistry. 20: 6366-74. PMID 23018094 DOI: 10.1016/J.Bmc.2012.08.058 |
0.806 |
|
| 2012 |
Chemel BR, Bonner LA, Watts VJ, Nichols DE. Ligand-specific roles for transmembrane 5 serine residues in the binding and efficacy of dopamine D(1) receptor catechol agonists. Molecular Pharmacology. 81: 729-38. PMID 22334593 DOI: 10.1124/Mol.111.077339 |
0.85 |
|
| 2012 |
McCorvy JD, Watts VJ, Nichols DE. Comparison of the D₁ dopamine full agonists, dihydrexidine and doxanthrine, in the 6-OHDA rat model of Parkinson's disease. Psychopharmacology. 222: 81-7. PMID 22222862 DOI: 10.1007/S00213-011-2625-5 |
0.7 |
|
| 2012 |
Halberstadt AL, Nichols DE, Geyer MA. Behavioral effects of α,α,β,β-tetradeutero-5-MeO-DMT in rats: comparison with 5-MeO-DMT administered in combination with a monoamine oxidase inhibitor. Psychopharmacology. 221: 709-18. PMID 22222861 DOI: 10.1007/S00213-011-2616-6 |
0.359 |
|
| 2012 |
Cueva JP, Chemel BR, Juncosa JI, Lill MA, Watts VJ, Nichols DE. Analogues of doxanthrine reveal differences between the dopamine D1 receptor binding properties of chromanoisoquinolines and hexahydrobenzo[a]phenanthridines. European Journal of Medicinal Chemistry. 48: 97-107. PMID 22204903 DOI: 10.1016/J.Ejmech.2011.11.039 |
0.84 |
|
| 2011 |
Clark AH, McCorvy JD, Watts VJ, Nichols DE. Assessment of dopamine D₁ receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393. Bioorganic & Medicinal Chemistry. 19: 5420-31. PMID 21862338 DOI: 10.1016/J.Bmc.2011.07.057 |
0.828 |
|
| 2011 |
McCorvy JD, Harland AA, Maglathlin R, Nichols DE. A 5-HT(2C) receptor antagonist potentiates a low dose amphetamine-induced conditioned place preference. Neuroscience Letters. 505: 10-3. PMID 21827831 DOI: 10.1016/J.Neulet.2011.07.036 |
0.709 |
|
| 2011 |
Marona-Lewicka D, Nichols DE. Potential serotonin 5-HT(1A) and dopamine D(4) receptor modulation of the discriminative stimulus effects of amphetamine in rats. Behavioural Pharmacology. 22: 508-15. PMID 21814134 DOI: 10.1097/FBP.0b013e328349fc31 |
0.497 |
|
| 2011 |
Cueva JP, Gallardo-Godoy A, Juncosa JI, Vidi PA, Lill MA, Watts VJ, Nichols DE. Probing the steric space at the floor of the D1 dopamine receptor orthosteric binding domain: 7α-, 7β-, 8α-, and 8β-methyl substituted dihydrexidine analogues. Journal of Medicinal Chemistry. 54: 5508-21. PMID 21714510 DOI: 10.1021/Jm200334C |
0.813 |
|
| 2011 |
Bonner LA, Laban U, Chemel BR, Juncosa JI, Lill MA, Watts VJ, Nichols DE. Mapping the catechol binding site in dopamine D₁ receptors: synthesis and evaluation of two parallel series of bicyclic dopamine analogues. Chemmedchem. 6: 1024-40. PMID 21538900 DOI: 10.1002/Cmdc.201100010 |
0.818 |
|
| 2011 |
Marona-Lewicka D, Nichols CD, Nichols DE. An animal model of schizophrenia based on chronic LSD administration: old idea, new results. Neuropharmacology. 61: 503-12. PMID 21352832 DOI: 10.1016/j.neuropharm.2011.02.006 |
0.573 |
|
| 2011 |
Clark LH, Cueva JP, McCorvy JD, Harland AA, Watts VJ, Nichols DE. C-Ring expanded analogs of doxanthrine: Conformation plays a critical role Arkivoc. 2010: 125-138. DOI: 10.3998/Ark.5550190.0011.411 |
0.85 |
|
| 2010 |
Bonner LA, Chemel BR, Watts VJ, Nichols DE. Facile synthesis of octahydrobenzo[h]isoquinolines: novel and highly potent D1 dopamine agonists. Bioorganic & Medicinal Chemistry. 18: 6763-70. PMID 20709559 DOI: 10.1016/J.Bmc.2010.07.052 |
0.841 |
|
| 2010 |
Laban U, Kurrasch-Orbaugh D, Marona-Lewicka D, Nichols DE. ChemInform Abstract: A Novel Fluorinated Tryptamine with Highly Potent Serotonin 5-HT1A Receptor Agonist Properties. Cheminform. 32: no-no. DOI: 10.1002/chin.200127116 |
0.841 |
|
| 2010 |
NEGASH K, NICHOLS DE, WATTS VJ, MAILMAN RB. ChemInform Abstract: Further Definition of the D1 Dopamine Receptor Pharmacophore: Synthesis of trans-6,6a,7,8,9,13b-Hexahydro-5H-benzo(d)naphth(2,1-b) azepines as Rigid Analogues of β-Phenyldopamine. Cheminform. 28: no-no. DOI: 10.1002/chin.199741209 |
0.367 |
|
| 2010 |
VANGVERAVONG S, NICHOLS DE. ChemInform Abstract: Stereoselective Synthesis of trans-2-(Indol-3-yl)cyclopropylamines: Rigid Tryptamine Analogues. Cheminform. 26: no-no. DOI: 10.1002/CHIN.199545041 |
0.664 |
|
| 2009 |
Trachsel D, Nichols DE, Kidd S, Hadorn M, Baumberger F. 4-aryl-substituted 2,5-dimethoxyphenethylamines: synthesis and serotonin 5-HT(2A) receptor affinities. Chemistry & Biodiversity. 6: 692-704. PMID 19479848 DOI: 10.1002/cbdv.200800235 |
0.542 |
|
| 2009 |
Marona-Lewicka D, Nichols DE. WAY 100635 produces discriminative stimulus effects in rats mediated by dopamine D(4) receptor activation. Behavioural Pharmacology. 20: 114-8. PMID 19179855 DOI: 10.1097/FBP.0b013e3283242f1a |
0.493 |
|
| 2009 |
Przybyla JA, Cueva JP, Chemel BR, Hsu KJ, Riese DJ, McCorvy JD, Chester JA, Nichols DE, Watts VJ. Comparison of the enantiomers of (+/-)-doxanthrine, a high efficacy full dopamine D(1) receptor agonist, and a reversal of enantioselectivity at D(1) versus alpha(2C) adrenergic receptors. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 19: 138-46. PMID 19028082 DOI: 10.1016/J.Euroneuro.2008.10.002 |
0.835 |
|
| 2009 |
Marona-Lewicka D, Chemel BR, Nichols DE. Dopamine D4 receptor involvement in the discriminative stimulus effects in rats of LSD, but not the phenethylamine hallucinogen DOI. Psychopharmacology. 203: 265-77. PMID 18604600 DOI: 10.1007/S00213-008-1238-0 |
0.828 |
|
| 2009 |
Cueva JP, Nichols DE. A novel and efficient synthesis of dihydrexidine Synthesis. 715-720. DOI: 10.1055/S-0028-1083359 |
0.746 |
|
| 2009 |
Weintraub HJR, Nichols DE. Conformational energy calculations of some amphetamine analogs using a new solvation model International Journal of Quantum Chemistry. 14: 321-343. DOI: 10.1002/QUA.560140731 |
0.315 |
|
| 2008 |
Torres-Altoro MI, White KJ, Rodríguez GJ, Nichols DE, Barker EL. Helix XI contributes to the entrance of the serotonin transporter permeation pathway. Protein Science : a Publication of the Protein Society. 17: 1761-70. PMID 18628241 DOI: 10.1110/Ps.036749.108 |
0.315 |
|
| 2008 |
Nichols DE, Nichols CD. Serotonin receptors. Chemical Reviews. 108: 1614-41. PMID 18476671 DOI: 10.1021/cr078224o |
0.602 |
|
| 2008 |
Nichols DE, Frescas SP, Chemel BR, Rehder KS, Zhong D, Lewin AH. High specific activity tritium-labeled N-(2-methoxybenzyl)-2,5-dimethoxy-4-iodophenethylamine (INBMeO): a high-affinity 5-HT2A receptor-selective agonist radioligand. Bioorganic & Medicinal Chemistry. 16: 6116-23. PMID 18468904 DOI: 10.1016/J.Bmc.2008.04.050 |
0.827 |
|
| 2008 |
Schultz DM, Prescher JA, Kidd S, Marona-Lewicka D, Nichols DE, Monte A. 'Hybrid' benzofuran-benzopyran congeners as rigid analogs of hallucinogenic phenethylamines. Bioorganic & Medicinal Chemistry. 16: 6242-51. PMID 18467103 DOI: 10.1016/J.Bmc.2008.04.030 |
0.516 |
|
| 2008 |
Walline CC, Nichols DE, Carroll FI, Barker EL. Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition. The Journal of Pharmacology and Experimental Therapeutics. 325: 791-800. PMID 18354055 DOI: 10.1124/jpet.108.136200 |
0.373 |
|
| 2008 |
Parker MA, Kurrasch DM, Nichols DE. The role of lipophilicity in determining binding affinity and functional activity for 5-HT2A receptor ligands. Bioorganic & Medicinal Chemistry. 16: 4661-9. PMID 18296055 DOI: 10.1016/j.bmc.2008.02.033 |
0.485 |
|
| 2007 |
Braden MR, Nichols DE. Assessment of the roles of serines 5.43(239) and 5.46(242) for binding and potency of agonist ligands at the human serotonin 5-HT2A receptor. Molecular Pharmacology. 72: 1200-9. PMID 17715398 DOI: 10.1124/Mol.107.039255 |
0.818 |
|
| 2007 |
Marona-Lewicka D, Nichols DE. Further evidence that the delayed temporal dopaminergic effects of LSD are mediated by a mechanism different than the first temporal phase of action. Pharmacology, Biochemistry, and Behavior. 87: 453-61. PMID 17618679 DOI: 10.1016/j.pbb.2007.06.001 |
0.504 |
|
| 2007 |
Mu Q, Johnson K, Morgan PS, Grenesko EL, Molnar CE, Anderson B, Nahas Z, Kozel FA, Kose S, Knable M, Fernandes P, Nichols DE, Mailman RB, George MS. A single 20 mg dose of the full D1 dopamine agonist dihydrexidine (DAR-0100) increases prefrontal perfusion in schizophrenia. Schizophrenia Research. 94: 332-41. PMID 17596915 DOI: 10.1016/J.Schres.2007.03.033 |
0.392 |
|
| 2007 |
George MS, Molnar CE, Grenesko EL, Anderson B, Mu Q, Johnson K, Nahas Z, Knable M, Fernandes P, Juncos J, Huang X, Nichols DE, Mailman RB. A single 20 mg dose of dihydrexidine (DAR-0100), a full dopamine D1 agonist, is safe and tolerated in patients with schizophrenia. Schizophrenia Research. 93: 42-50. PMID 17467956 DOI: 10.1016/J.Schres.2007.03.011 |
0.324 |
|
| 2007 |
Selken J, Nichols DE. Alpha1-adrenergic receptors mediate the locomotor response to systemic administration of (+/-)-3,4-methylenedioxymethamphetamine (MDMA) in rats. Pharmacology, Biochemistry, and Behavior. 86: 622-30. PMID 17363047 DOI: 10.1016/j.pbb.2007.02.006 |
0.376 |
|
| 2007 |
Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, Miller KJ, Spedding M, Mailman RB. Functional selectivity and classical concepts of quantitative pharmacology. The Journal of Pharmacology and Experimental Therapeutics. 320: 1-13. PMID 16803859 DOI: 10.1124/Jpet.106.104463 |
0.451 |
|
| 2006 |
Cueva JP, Giorgioni G, Grubbs RA, Chemel BR, Watts VJ, Nichols DE. trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist. Journal of Medicinal Chemistry. 49: 6848-57. PMID 17154515 DOI: 10.1021/Jm0604979 |
0.832 |
|
| 2006 |
Parrish JC, Nichols DE. Serotonin 5-HT(2A) receptor activation induces 2-arachidonoylglycerol release through a phospholipase c-dependent mechanism. Journal of Neurochemistry. 99: 1164-75. PMID 17010161 DOI: 10.1111/J.1471-4159.2006.04173.X |
0.8 |
|
| 2006 |
White KJ, Kiser PD, Nichols DE, Barker EL. Engineered zinc-binding sites confirm proximity and orientation of transmembrane helices I and III in the human serotonin transporter. Protein Science : a Publication of the Protein Society. 15: 2411-22. PMID 17008722 DOI: 10.1110/Ps.062386106 |
0.328 |
|
| 2006 |
Braden MR, Parrish JC, Naylor JC, Nichols DE. Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists. Molecular Pharmacology. 70: 1956-64. PMID 17000863 DOI: 10.1124/Mol.106.028720 |
0.846 |
|
| 2006 |
McLean TH, Parrish JC, Braden MR, Marona-Lewicka D, Gallardo-Godoy A, Nichols DE. 1-Aminomethylbenzocycloalkanes: conformationally restricted hallucinogenic phenethylamine analogues as functionally selective 5-HT2A receptor agonists. Journal of Medicinal Chemistry. 49: 5794-803. PMID 16970404 DOI: 10.1021/Jm060656O |
0.856 |
|
| 2006 |
Chemel BR, Roth BL, Armbruster B, Watts VJ, Nichols DE. WAY-100635 is a potent dopamine D4 receptor agonist. Psychopharmacology. 188: 244-51. PMID 16915381 DOI: 10.1007/S00213-006-0490-4 |
0.856 |
|
| 2006 |
McLean TH, Chambers JJ, Parrish JC, Braden MR, Marona-Lewicka D, Kurrasch-Orbaugh D, Nichols DE. C-(4,5,6-trimethoxyindan-1-yl)methanamine: a mescaline analogue designed using a homology model of the 5-HT2A receptor. Journal of Medicinal Chemistry. 49: 4269-74. PMID 16821786 DOI: 10.1021/Jm060272Y |
0.832 |
|
| 2006 |
Lewis MM, Huang X, Nichols DE, Mailman RB. D1 and functionally selective dopamine agonists as neuroprotective agents in Parkinson's disease. Cns & Neurological Disorders Drug Targets. 5: 345-53. PMID 16787233 DOI: 10.2174/187152706777452245 |
0.319 |
|
| 2005 |
Parrish JC, Braden MR, Gundy E, Nichols DE. Differential phospholipase C activation by phenylalkylamine serotonin 5-HT 2A receptor agonists. Journal of Neurochemistry. 95: 1575-84. PMID 16277614 DOI: 10.1111/J.1471-4159.2005.03477.X |
0.846 |
|
| 2005 |
Ryman-Rasmussen JP, Nichols DE, Mailman RB. Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists. Molecular Pharmacology. 68: 1039-48. PMID 15985612 DOI: 10.1124/mol.105.012153 |
0.571 |
|
| 2005 |
Gallardo-Godoy A, Fierro A, McLean TH, Castillo M, Cassels BK, Reyes-Parada M, Nichols DE. Sulfur-substituted alpha-alkyl phenethylamines as selective and reversible MAO-A inhibitors: biological activities, CoMFA analysis, and active site modeling. Journal of Medicinal Chemistry. 48: 2407-19. PMID 15801832 DOI: 10.1021/jm0493109 |
0.376 |
|
| 2005 |
Marona-Lewicka D, Thisted RA, Nichols DE. Distinct temporal phases in the behavioral pharmacology of LSD: dopamine D2 receptor-mediated effects in the rat and implications for psychosis. Psychopharmacology. 180: 427-35. PMID 15723230 DOI: 10.1007/s00213-005-2183-9 |
0.426 |
|
| 2004 |
Hrometz SL, Brown AW, Nichols DE, Sprague JE. 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-mediated production of hydrogen peroxide in an in vitro model: the role of dopamine, the serotonin-reuptake transporter, and monoamine oxidase-B. Neuroscience Letters. 367: 56-9. PMID 15308297 DOI: 10.1016/J.Neulet.2004.05.075 |
0.357 |
|
| 2004 |
Gay EA, Urban JD, Nichols DE, Oxford GS, Mailman RB. Functional selectivity of D2 receptor ligands in a Chinese hamster ovary hD2L cell line: evidence for induction of ligand-specific receptor states. Molecular Pharmacology. 66: 97-105. PMID 15213300 DOI: 10.1124/Mol.66.1.97 |
0.482 |
|
| 2004 |
Grubbs RA, Lewis MM, Owens-Vance C, Gay EA, Jassen AK, Mailman RB, Nichols DE. 8,9-dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2,-de]isoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms. Bioorganic & Medicinal Chemistry. 12: 1403-12. PMID 15018913 DOI: 10.1016/J.Bmc.2004.01.008 |
0.841 |
|
| 2004 |
Nichols DE. Hallucinogens. Pharmacology & Therapeutics. 101: 131-81. PMID 14761703 DOI: 10.1016/j.pharmthera.2003.11.002 |
0.344 |
|
| 2004 |
Sit SY, Xie K, Jacutin-Porte S, Boy KM, Seanz J, Taber MT, Gulwadi AG, Korpinen CD, Burris KD, Molski TF, Ryan E, Xu C, Verdoorn T, Johnson G, Nichols DE, et al. Synthesis and SAR exploration of dinapsoline analogues. Bioorganic & Medicinal Chemistry. 12: 715-34. PMID 14759732 DOI: 10.1016/j.bmc.2003.11.015 |
0.528 |
|
| 2004 |
Marona-Lewicka D, Nichols DE. Aripiprazole (OPC-14597) fully substitutes for the 5-HT1A receptor agonist LY293284 in the drug discrimination assay in rats. Psychopharmacology. 172: 415-21. PMID 14647959 DOI: 10.1007/s00213-003-1677-6 |
0.552 |
|
| 2004 |
Roman DL, Saldaña SN, Nichols DE, Carroll FI, Barker EL. Distinct molecular recognition of psychostimulants by human and Drosophila serotonin transporters. The Journal of Pharmacology and Experimental Therapeutics. 308: 679-87. PMID 14593087 DOI: 10.1124/Jpet.103.057836 |
0.413 |
|
| 2004 |
Nichols DE, Lewis MM. Mechanisms and issues relating to the use of D1-like dopamine receptor agonists for age-related illnesses: Parkinson's disease and memory and cognition Medicinal Chemistry Research. 13: 105-114. DOI: 10.1007/s00044-004-0016-8 |
0.38 |
|
| 2003 |
Kurrasch-Orbaugh DM, Parrish JC, Watts VJ, Nichols DE. A complex signaling cascade links the serotonin2A receptor to phospholipase A2 activation: the involvement of MAP kinases. Journal of Neurochemistry. 86: 980-91. PMID 12887695 DOI: 10.1046/J.1471-4159.2003.01921.X |
0.824 |
|
| 2003 |
Chambers JJ, Parrish JC, Jensen NH, Kurrasch-Orbaugh DM, Marona-Lewicka D, Nichols DE. Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands. Journal of Medicinal Chemistry. 46: 3526-35. PMID 12877591 DOI: 10.1021/Jm030064V |
0.838 |
|
| 2003 |
Rodríguez GJ, Roman DL, White KJ, Nichols DE, Barker EL. Distinct recognition of substrates by the human and Drosophila serotonin transporters. The Journal of Pharmacology and Experimental Therapeutics. 306: 338-46. PMID 12682215 DOI: 10.1124/Jpet.103.048751 |
0.364 |
|
| 2003 |
Qandil AM, Lewis MM, Jassen A, Leonard SK, Mailman RB, Nichols DE. Synthesis and pharmacological evaluation of substituted naphth[1,2,3-de]isoquinolines (dinapsoline analogues) as D1 and D2 dopamine receptor ligands. Bioorganic & Medicinal Chemistry. 11: 1451-64. PMID 12628671 DOI: 10.1016/S0968-0896(02)00561-8 |
0.483 |
|
| 2003 |
Kurrasch-Orbaugh DM, Watts VJ, Barker EL, Nichols DE. Serotonin 5-hydroxytryptamine 2A receptor-coupled phospholipase C and phospholipase A2 signaling pathways have different receptor reserves. The Journal of Pharmacology and Experimental Therapeutics. 304: 229-37. PMID 12490596 DOI: 10.1124/Jpet.102.042184 |
0.837 |
|
| 2002 |
Chambers JJ, Nichols DE. A homology-based model of the human 5-HT2A receptor derived from an in silico activated G-protein coupled receptor. Journal of Computer-Aided Molecular Design. 16: 511-20. PMID 12510883 DOI: 10.1023/A:1021275430021 |
0.692 |
|
| 2002 |
Kanthasamy A, Sprague JE, Shotwell JR, Nichols DE. Unilateral infusion of a dopamine transporter antisense into the substantia nigra protects against MDMA-induced serotonergic deficits in the ipsilateral striatum. Neuroscience. 114: 917-24. PMID 12379247 DOI: 10.1016/S0306-4522(02)00368-8 |
0.608 |
|
| 2002 |
Marona-Lewicka D, Kurrasch-Orbaugh DM, Selken JR, Cumbay MG, Lisnicchia JG, Nichols DE. Re-evaluation of lisuride pharmacology: 5-hydroxytryptamine1A receptor-mediated behavioral effects overlap its other properties in rats. Psychopharmacology. 164: 93-107. PMID 12373423 DOI: 10.1007/S00213-002-1141-Z |
0.842 |
|
| 2002 |
Nichols DE, Frescas S, Marona-Lewicka D, Kurrasch-Orbaugh DM. Lysergamides of isomeric 2,4-dimethylazetidines map the binding orientation of the diethylamide moiety in the potent hallucinogenic agent N,N-diethyllysergamide (LSD). Journal of Medicinal Chemistry. 45: 4344-9. PMID 12213075 DOI: 10.1021/Jm020153S |
0.815 |
|
| 2002 |
Falk EM, Cook VJ, Nichols DE, Sprague JE. An antisense oligonucleotide targeted at MAO-B attenuates rat striatal serotonergic neurotoxicity induced by MDMA. Pharmacology, Biochemistry, and Behavior. 72: 617-22. PMID 12175458 DOI: 10.1016/S0091-3057(02)00728-1 |
0.359 |
|
| 2002 |
Whiteside MS, Kurrasch-Orbaugh D, Marona-Lewicka D, Nichols DE, Monte A. Substituted hexahydrobenzodipyrans as 5-HT2A/2C receptor probes. Bioorganic & Medicinal Chemistry. 10: 3301-6. PMID 12150876 DOI: 10.1016/S0968-0896(02)00209-2 |
0.836 |
|
| 2002 |
Chambers JJ, Kurrasch-Orbaugh DM, Nichols DE. Translocation of the 5-alkoxy substituent of 2,5-dialkoxyarylalkylamines to the 6-position: effects on 5-HT(2A/2C) receptor affinity. Bioorganic & Medicinal Chemistry Letters. 12: 1997-9. PMID 12113827 DOI: 10.1016/S0960-894X(02)00306-2 |
0.833 |
|
| 2002 |
Kilts JD, Connery HS, Arrington EG, Lewis MM, Lawler CP, Oxford GS, O'Malley KL, Todd RD, Blake BL, Nichols DE, Mailman RB. Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs. The Journal of Pharmacology and Experimental Therapeutics. 301: 1179-89. PMID 12023553 DOI: 10.1124/jpet.301.3.1179 |
0.527 |
|
| 2002 |
Mottola DM, Kilts JD, Lewis MM, Connery HS, Walker QD, Jones SR, Booth RG, Hyslop DK, Piercey M, Wightman RM, Lawler CP, Nichols DE, Mailman RB. Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase. The Journal of Pharmacology and Experimental Therapeutics. 301: 1166-78. PMID 12023552 DOI: 10.1124/jpet.301.3.1166 |
0.549 |
|
| 2002 |
Sprague JE, Leifheit M, Selken J, Milks MM, Kinder DH, Nichols DE. In vivo microdialysis and conditioned place preference studies in rats are consistent with abuse potential of tramadol. Synapse (New York, N.Y.). 43: 118-21. PMID 11754490 DOI: 10.1002/Syn.10025 |
0.314 |
|
| 2001 |
Mailman R, Huang X, Nichols DE. Parkinson's disease and D1 dopamine receptors. Current Opinion in Investigational Drugs (London, England : 2000). 2: 1582-91. PMID 11763161 |
0.346 |
|
| 2001 |
Huang X, Lawler CP, Lewis MM, Nichols DE, Mailman RB. D1 dopamine receptors. International Review of Neurobiology. 48: 65-139. PMID 11526741 DOI: 10.1016/S0074-7742(01)48014-7 |
0.526 |
|
| 2001 |
Chambers JJ, Kurrasch-Orbaugh DM, Parker MA, Nichols DE. Enantiospecific synthesis and pharmacological evaluation of a series of super-potent, conformationally restricted 5-HT(2A/2C) receptor agonists. Journal of Medicinal Chemistry. 44: 1003-10. PMID 11300881 DOI: 10.1021/Jm000491Y |
0.855 |
|
| 2001 |
Laban U, Kurrasch-Orbaugh D, Marona-Lewicka D, Nichols DE. A novel fluorinated tryptamine with highly potent serotonin 5-HT1A receptor agonist properties. Bioorganic & Medicinal Chemistry Letters. 11: 793-5. PMID 11277522 DOI: 10.1016/S0960-894X(01)00062-2 |
0.83 |
|
| 2001 |
Gulwadi AG, Korpinen CD, Mailman RB, Nichols DE, Sit SY, Taber MT. Dinapsoline: characterization of a D1 dopamine receptor agonist in a rat model of Parkinson's disease. The Journal of Pharmacology and Experimental Therapeutics. 296: 338-44. PMID 11160615 |
0.384 |
|
| 2001 |
Sattelkau T, Qandil AM, Nichols DE. An efficient synthesis of the potent dopamine D1 agonist dinapsoline by construction and selective reduction of 2′-azadimethoxybenzanthrone Synthesis. 262-266. DOI: 10.1055/S-2001-10809 |
0.454 |
|
| 2001 |
Blair JB, Kurrasch-Orbaugh D, Marona-Lewicka D, Cumbay MG, Watts VJ, Barker EL, Nichols DE. ChemInform Abstract: Effect of Ring Fluorination on the Pharmacology of Hallucinogenic Tryptamines. Cheminform. 32: no-no. DOI: 10.1002/chin.200111113 |
0.762 |
|
| 2000 |
Blair JB, Kurrasch-Orbaugh D, Marona-Lewicka D, Cumbay MG, Watts VJ, Barker EL, Nichols DE. Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines. Journal of Medicinal Chemistry. 43: 4701-10. PMID 11101361 DOI: 10.1021/Jm000339W |
0.835 |
|
| 1999 |
Gerasimov M, Marona-Lewicka D, Kurrasch-Orbaugh DM, Qandil AM, Nichols DE. Further studies on oxygenated tryptamines with LSD-like activity incorporating a chiral pyrrolidine moiety into the side chain. Journal of Medicinal Chemistry. 42: 4257-63. PMID 10514296 DOI: 10.1021/Jm990325U |
0.844 |
|
| 1999 |
Hoffman B, Cho SJ, Zheng W, Wyrick S, Nichols DE, Mailman RB, Tropsha A. Quantitative structure-activity relationship modeling of dopamine D(1) antagonists using comparative molecular field analysis, genetic algorithms-partial least-squares, and K nearest neighbor methods. Journal of Medicinal Chemistry. 42: 3217-26. PMID 10464009 DOI: 10.1021/jm980415j |
0.367 |
|
| 1999 |
Scorza C, Silveira R, Nichols DE, Reyes-Parada M. Effects of 5-HT-releasing agents on the extracellullar hippocampal 5-HT of rats. Implications for the development of novel antidepressants with a short onset of action. Neuropharmacology. 38: 1055-61. PMID 10428424 DOI: 10.1016/S0028-3908(99)00023-4 |
0.395 |
|
| 1999 |
Blair JB, Marona-Lewicka D, Kanthasamy A, Lucaites VL, Nelson DL, Nichols DE. Thieno[3,2-b]- and thieno[2,3-b]pyrrole bioisosteric analogues of the hallucinogen and serotonin agonist N,N-dimethyltryptamine. Journal of Medicinal Chemistry. 42: 1106-11. PMID 10090793 DOI: 10.1021/Jm980692Q |
0.7 |
|
| 1999 |
Doll MK, Nichols DE, Kilts JD, Prioleau C, Lawler CP, Lewis MM, Mailman RB. Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane. Journal of Medicinal Chemistry. 42: 935-40. PMID 10072690 DOI: 10.1021/jm9804533 |
0.566 |
|
| 1999 |
Qandil AM, Ghosh D, Nichols DE. Alternative formal synthesis of the potent D1 dopamine agonist dihydroxy-2,3,7,11b-tetrahydro-1H-naphth[1,2,3-de]isoquinoline: Dinapsoline Journal of Organic Chemistry. 64: 1407-1409. DOI: 10.1021/jo982067z |
0.444 |
|
| 1998 |
Parker MA, Marona-Lewicka D, Lucaites VL, Nelson DL, Nichols DE. A novel (benzodifuranyl)aminoalkane with extremely potent activity at the 5-HT2A receptor. Journal of Medicinal Chemistry. 41: 5148-9. PMID 9857084 DOI: 10.1021/Jm9803525 |
0.478 |
|
| 1998 |
Vangveravong S, Kanthasamy A, Lucaites VL, Nelson DL, Nichols DE. Synthesis and serotonin receptor affinities of a series of trans-2-(indol-3-yl)cyclopropylamine derivatives. Journal of Medicinal Chemistry. 41: 4995-5001. PMID 9836617 DOI: 10.1021/Jm980318Q |
0.836 |
|
| 1998 |
Lieberman JA, Mailman RB, Duncan G, Sikich L, Chakos M, Nichols DE, Kraus JE. Serotonergic basis of antipsychotic drug effects in schizophrenia. Biological Psychiatry. 44: 1099-117. PMID 9836014 DOI: 10.1016/S0006-3223(98)00187-5 |
0.401 |
|
| 1998 |
Troconis M, Ma W, Nichols DE, McLaughlin J. Molecular modeling study of tubulosine and other related ipecac alkaloids. Journal of Computer-Aided Molecular Design. 12: 411-8. PMID 9834903 DOI: 10.1023/A:1008019720578 |
0.38 |
|
| 1998 |
Mailman RB, Nichols DE. Dopamine D1 receptor agonists as antiparkinson drugs. Trends in Pharmacological Sciences. 19: 255-6. PMID 9703756 DOI: 10.1016/S0165-6147(98)01219-X |
0.392 |
|
| 1998 |
Marona-Lewicka D, Nichols DE. Drug discrimination studies of the interoceptive cues produced by selective serotonin uptake inhibitors and selective serotonin releasing agents. Psychopharmacology. 138: 67-75. PMID 9694528 DOI: 10.1007/s002130050646 |
0.375 |
|
| 1998 |
Lewis MM, Watts VJ, Lawler CP, Nichols DE, Mailman RB. Homologous desensitization of the D1A dopamine receptor: efficacy in causing desensitization dissociates from both receptor occupancy and functional potency. The Journal of Pharmacology and Experimental Therapeutics. 286: 345-53. PMID 9655879 |
0.47 |
|
| 1998 |
Monte AP, Marona-Lewicka D, Lewis MM, Mailman RB, Wainscott DB, Nelson DL, Nichols DE. Substituted naphthofurans as hallucinogenic phenethylamine-ergoline hybrid molecules with unexpected muscarinic antagonist activity. Journal of Medicinal Chemistry. 41: 2134-45. PMID 9622555 DOI: 10.1021/jm980076u |
0.564 |
|
| 1998 |
Parker MA, Marona-Lewicka D, Kurrasch D, Shulgin AT, Nichols DE. Synthesis and pharmacological evaluation of ring-methylated derivatives of 3,4-(methylenedioxy)amphetamine (MDA). Journal of Medicinal Chemistry. 41: 1001-5. PMID 9526575 DOI: 10.1021/jm9705925 |
0.455 |
|
| 1998 |
Cozzi NV, Frescas S, Marona-Lewicka D, Huang X, Nichols DE. Indan analogs of fenfluramine and norfenfluramine have reduced neurotoxic potential. Pharmacology, Biochemistry, and Behavior. 59: 709-15. PMID 9512076 DOI: 10.1016/S0091-3057(97)00557-1 |
0.398 |
|
| 1997 |
Marona-Lewicka D, Nichols DE. The Effect of Selective Serotonin Releasing Agents in the Chronic Mild Stress Model of Depression in Rats. Stress (Amsterdam, Netherlands). 2: 91-100. PMID 9787258 DOI: 10.3109/10253899709014740 |
0.31 |
|
| 1997 |
Marona-Lewicka D, Nichols DE. 5-HT2A/2C receptor agonists potentiate the discriminative cue of (+)-amphetamine in the rat. Neuropharmacology. 36: 1471-5. PMID 9423936 DOI: 10.1016/S0028-3908(97)00106-8 |
0.405 |
|
| 1997 |
Monte AP, Waldman SR, Marona-Lewicka D, Wainscott DB, Nelson DL, Sanders-Bush E, Nichols DE. Dihydrobenzofuran analogues of hallucinogens. 4. Mescaline derivatives. Journal of Medicinal Chemistry. 40: 2997-3008. PMID 9301661 DOI: 10.1021/jm970219x |
0.532 |
|
| 1997 |
Negash K, Nichols DE, Watts VJ, Mailman RB. Further definition of the D1 dopamine receptor pharmacophore: synthesis of trans-6,6a,7,8,9,13b-hexahydro-5H-benzo[d]naphth[2,1-b]azepines as rigid analogues of beta-phenyldopamine. Journal of Medicinal Chemistry. 40: 2140-7. PMID 9216832 DOI: 10.1021/Jm970157A |
0.445 |
|
| 1997 |
Smith HP, Nichols DE, Mailman RB, Lawler CP. Locomotor inhibition, yawning and vacuous chewing induced by a novel dopamine D2 post-synaptic receptor agonist. European Journal of Pharmacology. 323: 27-36. PMID 9105873 DOI: 10.1016/S0014-2999(97)00026-5 |
0.518 |
|
| 1996 |
Reyes-Parada M, Scorza C, Romero V, Silveira R, Medina JH, Andrus D, Nichols DE, Cassels BK. (+/-)-1-(2,5-Dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2), a novel putative anxiolytic agent lacking affinity for benzodiazepine sites and serotonin-1A receptors. Naunyn-Schmiedeberg's Archives of Pharmacology. 354: 579-85. PMID 8938655 DOI: 10.1007/Bf00170831 |
0.461 |
|
| 1996 |
Sprague JE, Johnson MP, Schmidt CJ, Nichols DE. Studies on the mechanism of p-chloroamphetamine neurotoxicity. Biochemical Pharmacology. 52: 1271-7. PMID 8937435 DOI: 10.1016/0006-2952(96)00482-0 |
0.361 |
|
| 1996 |
Cozzi NV, Nichols DE. 5-HT2A receptor antagonists inhibit potassium-stimulated gamma-aminobutyric acid release in rat frontal cortex. European Journal of Pharmacology. 309: 25-31. PMID 8864689 DOI: 10.1016/0014-2999(96)00325-1 |
0.368 |
|
| 1996 |
Marona-Lewicka D, Rhee GS, Sprague JE, Nichols DE. Reinforcing effects of certain serotonin-releasing amphetamine derivatives. Pharmacology, Biochemistry, and Behavior. 53: 99-105. PMID 8848466 DOI: 10.1016/0091-3057(95)00205-7 |
0.331 |
|
| 1996 |
Nichols DE, Monte A, Huang X, Marona-Lewicka D. Stereoselective pharmacological effects of lysergic acid amides possessing chirality in the amide substituent. Behavioural Brain Research. 73: 117-9. PMID 8788487 DOI: 10.1016/0166-4328(96)00080-0 |
0.473 |
|
| 1996 |
Monte AP, Marona-Lewicka D, Parker MA, Wainscott DB, Nelson DL, Nichols DE. Dihydrobenzofuran analogues of hallucinogens. 3. Models of 4-substituted (2,5-dimethoxyphenyl)alkylamine derivatives with rigidified methoxy groups. Journal of Medicinal Chemistry. 39: 2953-61. PMID 8709129 DOI: 10.1021/jm960199j |
0.53 |
|
| 1996 |
Mottola DM, Laiter S, Watts VJ, Tropsha A, Wyrick SD, Nichols DE, Mailman RB. Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping. Journal of Medicinal Chemistry. 39: 285-96. PMID 8568818 DOI: 10.1021/Jm9502100 |
0.567 |
|
| 1996 |
Ghosh D, Snyder SE, Watts VJ, Mailman RB, Nichols DE. 9-Dihydroxy-2,3,7,11b-tetrahydro-1H-naph[1,2,3-de]isoquinoline: a potent full dopamine D1 agonist containing a rigid-beta-phenyldopamine pharmacophore. Journal of Medicinal Chemistry. 39: 549-55. PMID 8558526 DOI: 10.1021/Jm950707+ |
0.462 |
|
| 1995 |
Marona-Lewicka D, Rhee GS, Sprague JE, Nichols DE. Psychostimulant-like effects of p-fluoroamphetamine in the rat. European Journal of Pharmacology. 287: 105-13. PMID 8749023 DOI: 10.1016/0014-2999(95)00478-5 |
0.384 |
|
| 1995 |
Watts VJ, Lawler CP, Gonzales AJ, Zhou QY, Civelli O, Nichols DE, Mailman RB. Spare receptors and intrinsic activity: studies with D1 dopamine receptor agonists. Synapse (New York, N.Y.). 21: 177-87. PMID 8584979 DOI: 10.1002/syn.890210211 |
0.544 |
|
| 1995 |
Marona-Lewicka D, Nichols DE. Complex stimulus properties of LSD: a drug discrimination study with alpha 2-adrenoceptor agonists and antagonists. Psychopharmacology. 120: 384-91. PMID 8539318 DOI: 10.1007/BF02245809 |
0.429 |
|
| 1995 |
Brewster WK, Nichols DE, Watts VJ, Riggs RM, Mottola D, Mailman RB. Evaluation of cis- and trans-9- and 11-hydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridines as structurally rigid, selective D1 dopamine receptor ligands. Journal of Medicinal Chemistry. 38: 318-27. PMID 7830274 DOI: 10.1021/Jm00002A013 |
0.852 |
|
| 1995 |
Heidenreich BA, Mailman RB, Nichols DE, Napier TC. Partial and full dopamine D1 agonists produce comparable increases in ventral pallidal neuronal activity: contribution of endogenous dopamine. The Journal of Pharmacology and Experimental Therapeutics. 273: 516-25. PMID 7714807 |
0.331 |
|
| 1995 |
Monte AP, Marona-Lewicka D, Kanthasamy A, Sanders-Bush E, Nichols DE. Stereoselective LSD-like activity in a series of d-lysergic acid amides of (R)- and (S)-2-aminoalkanes. Journal of Medicinal Chemistry. 38: 958-66. PMID 7699712 DOI: 10.1021/Jm00006A015 |
0.638 |
|
| 1995 |
Oberlender R, Ramachandran PV, Johnson MP, Huang X, Nichols DE. Effect of a chiral 4-alkyl substituent in hallucinogenic amphetamines. Journal of Medicinal Chemistry. 38: 3593-601. PMID 7658446 |
0.421 |
|
| 1995 |
Knoerzer TA, Watts VJ, Nichols DE, Mailman RB. Synthesis and biological evaluation of a series of substituted benzo[a]phenanthridines as agonists at D1 and D2 dopamine receptors. Journal of Medicinal Chemistry. 38: 3062-70. PMID 7636869 DOI: 10.1021/Jm00016A009 |
0.432 |
|
| 1995 |
Snyder SE, Aviles-Garay FA, Chakraborti R, Nichols DE, Watts VJ, Mailman RB. Synthesis and evaluation of 6,7-dihydroxy-2,3,4,8,9,13b-hexahydro-1H- benzo[6,7]cyclohepta[1,2,3-ef][3]benzazepine, 6,7-dihydroxy- 1,2,3,4,8,12b-hexahydroanthr[10,4a,4-cd]azepine, and 10-(aminomethyl)-9,10- dihydro-1,2-dihydroxyanthracene as conformationally restricted analogs of beta-phenyldopamine. Journal of Medicinal Chemistry. 38: 2395-409. PMID 7608904 DOI: 10.1021/Jm00013A015 |
0.519 |
|
| 1995 |
Watts VJ, Lawler CP, Fox DR, Neve KA, Nichols DE, Mailman RB. LSD and structural analogs: pharmacological evaluation at D1 dopamine receptors. Psychopharmacology. 118: 401-9. PMID 7568626 DOI: 10.1007/Bf02245940 |
0.579 |
|
| 1995 |
Gilmore JH, Watts VJ, Lawler CP, Noll EP, Nichols DE, Mailman RB. "Full" dopamine D1 agonists in human caudate: biochemical properties and therapeutic implications. Neuropharmacology. 34: 481-8. PMID 7566481 DOI: 10.1016/0028-3908(95)00014-W |
0.541 |
|
| 1995 |
Sprague JE, Nichols DE. Inhibition of MAO-B protects against MDMA-induced neurotoxicity in the striatum. Psychopharmacology. 118: 357-9. PMID 7542394 DOI: 10.1007/Bf02245967 |
0.38 |
|
| 1995 |
Vangveravong S, Nichols DE. Stereoselective synthesis of trans-2-(indol-3-yl)cyclopropylamines: Rigid tryptamine analogues Journal of Organic Chemistry. 60: 3409-3413. DOI: 10.1021/Jo00116A028 |
0.681 |
|
| 1994 |
Huang X, Marona-Lewicka D, Pfaff RC, Nichols DE. Drug discrimination and receptor binding studies of N-isopropyl lysergamide derivatives. Pharmacology, Biochemistry, and Behavior. 47: 667-73. PMID 8208787 DOI: 10.1016/0091-3057(94)90172-4 |
0.303 |
|
| 1994 |
Nichols DE, Frescas S, Marona-Lewicka D, Huang X, Roth BL, Gudelsky GA, Nash JF. 1-(2,5-Dimethoxy-4-(trifluoromethyl)phenyl)-2-aminopropane: a potent serotonin 5-HT2A/2C agonist. Journal of Medicinal Chemistry. 37: 4346-51. PMID 7996545 DOI: 10.1021/Jm00051A011 |
0.543 |
|
| 1994 |
Minor DL, Wyrick SD, Charifson PS, Watts VJ, Nichols DE, Mailman RB. Synthesis and molecular modeling of 1-phenyl-1,2,3,4-tetrahydroisoquinolines and related 5,6,8,9-tetrahydro-13bH-dibenzo[a,h]quinolizines as D1 dopamine antagonists. Journal of Medicinal Chemistry. 37: 4317-28. PMID 7996543 DOI: 10.1021/Jm00051A008 |
0.527 |
|
| 1994 |
Sprague JE, Huang X, Kanthasamy A, Nichols DE. Attenuation of 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity with the serotonin precursors tryptophan and 5-hydroxytryptophan. Life Sciences. 55: 1193-8. PMID 7934616 DOI: 10.1016/0024-3205(94)00658-X |
0.613 |
|
| 1994 |
Marona-Lewicka D, Nichols DE. Behavioral effects of the highly selective serotonin releasing agent 5-methoxy-6-methyl-2-aminoindan. European Journal of Pharmacology. 258: 1-13. PMID 7925587 DOI: 10.1016/0014-2999(94)90051-5 |
0.428 |
|
| 1994 |
Knoerzer TA, Nichols DE, Brewster WK, Watts VJ, Mottola D, Mailman RB. Dopaminergic benzo[a]phenanthridines: resolution and pharmacological evaluation of the enantiomers of dihydrexidine, the full efficacy D1 dopamine receptor agonist. Journal of Medicinal Chemistry. 37: 2453-60. PMID 7914538 DOI: 10.1021/Jm00041A025 |
0.853 |
|
| 1994 |
Lewis MH, Gariépy JL, Gendreau P, Nichols DE, Mailman RB. Social reactivity and D1 dopamine receptors: studies in mice selectively bred for high and low levels of aggression. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 10: 115-22. PMID 7912934 DOI: 10.1038/npp.1994.13 |
0.371 |
|
| 1994 |
Nash JF, Roth BL, Brodkin JD, Nichols DE, Gudelsky GA. Effect of the R(-) and S(+) isomers of MDA and MDMA on phosphatidyl inositol turnover in cultured cells expressing 5-HT2A or 5-HT2C receptors. Neuroscience Letters. 177: 111-5. PMID 7824160 DOI: 10.1016/0304-3940(94)90057-4 |
0.49 |
|
| 1993 |
Monte AP, Marona-Lewicka D, Cozzi NV, Nichols DE. Synthesis and pharmacological examination of benzofuran, indan, and tetralin analogues of 3,4-(methylenedioxy)amphetamine. Journal of Medicinal Chemistry. 36: 3700-6. PMID 8246240 |
0.306 |
|
| 1993 |
Watts VJ, Lawler CP, Knoerzer T, Mayleben MA, Neve KA, Nichols DE, Mailman RB. Hexahydrobenzo[a]phenanthridines: novel dopamine D3 receptor ligands. European Journal of Pharmacology. 239: 271-3. PMID 8223910 DOI: 10.1016/0014-2999(93)91012-C |
0.55 |
|
| 1993 |
Huang X, Nichols DE. 5-HT2 receptor-mediated potentiation of dopamine synthesis and central serotonergic deficits. European Journal of Pharmacology. 238: 291-6. PMID 8104811 DOI: 10.1016/0014-2999(93)90859-G |
0.385 |
|
| 1993 |
Kohli JD, Horn PT, Glock D, Brewster WK, Nichols DE. Dihydrexidine: a new potent peripheral dopamine D1 receptor agonist. European Journal of Pharmacology. 235: 31-5. PMID 8100195 DOI: 10.1016/0014-2999(93)90816-Z |
0.847 |
|
| 1993 |
Watts VJ, Lawler CP, Gilmore JH, Southerland SB, Nichols DE, Mailman RB. Dopamine D1 receptors: efficacy of full (dihydrexidine) vs. partial (SKF38393) agonists in primates vs. rodents. European Journal of Pharmacology. 242: 165-72. PMID 7902811 DOI: 10.1016/0014-2999(93)90076-T |
0.504 |
|
| 1993 |
Callaway CW, Wing LL, Nichols DE, Geyer MA. Suppression of behavioral activity by norfenfluramine and related drugs in rats is not mediated by serotonin release. Psychopharmacology. 111: 169-78. PMID 7870948 DOI: 10.1007/BF02245519 |
0.401 |
|
| 1992 |
Oberlender R, Pfaff RC, Johnson MP, Huang XM, Nichols DE. Stereoselective LSD-like activity in d-lysergic acid amides of (R)- and (S)-2-aminobutane. Journal of Medicinal Chemistry. 35: 203-11. PMID 1732537 DOI: 10.1021/Jm00080A001 |
0.478 |
|
| 1992 |
Tomaszewski Z, Johnson MP, Huang X, Nichols DE. Benzofuran bioisosteres of hallucinogenic tryptamines. Journal of Medicinal Chemistry. 35: 2061-4. PMID 1534585 |
0.44 |
|
| 1992 |
Mottola DM, Brewster WK, Cook LL, Nichols DE, Mailman RB. Dihydrexidine, a novel full efficacy D1 dopamine receptor agonist. The Journal of Pharmacology and Experimental Therapeutics. 262: 383-93. PMID 1352553 |
0.419 |
|
| 1991 |
Oberlender R, Nichols DE. Structural variation and (+)-amphetamine-like discriminative stimulus properties. Pharmacology, Biochemistry, and Behavior. 38: 581-6. PMID 2068194 DOI: 10.1016/0091-3057(91)90017-V |
0.316 |
|
| 1991 |
Nichols DE, Snyder SE, Oberlender R, Johnson MP, Huang XM. 2,3-Dihydrobenzofuran analogues of hallucinogenic phenethylamines. Journal of Medicinal Chemistry. 34: 276-81. PMID 1992127 DOI: 10.1021/JM00105A043 |
0.395 |
|
| 1991 |
Callaway CW, Johnson MP, Gold LH, Nichols DE, Geyer MA. Amphetamine derivatives induce locomotor hyperactivity by acting as indirect serotonin agonists. Psychopharmacology. 104: 293-301. PMID 1924637 DOI: 10.1007/BF02246026 |
0.401 |
|
| 1991 |
Nichols DE, Johnson MP, Oberlender R. 5-Iodo-2-aminoindan, a nonneurotoxic analogue of p-iodoamphetamine. Pharmacology, Biochemistry, and Behavior. 38: 135-9. PMID 1826785 DOI: 10.1016/0091-3057(91)90601-W |
0.408 |
|
| 1991 |
Johnson MP, Huang XM, Nichols DE. Serotonin neurotoxicity in rats after combined treatment with a dopaminergic agent followed by a nonneurotoxic 3,4-methylenedioxymethamphetamine (MDMA) analogue. Pharmacology, Biochemistry, and Behavior. 40: 915-22. PMID 1726189 DOI: 10.1016/0091-3057(91)90106-C |
0.377 |
|
| 1991 |
Nash JF, Nichols DE. Microdialysis studies on 3,4-methylenedioxyamphetamine and structurally related analogues. European Journal of Pharmacology. 200: 53-8. PMID 1722755 DOI: 10.1016/0014-2999(91)90664-C |
0.388 |
|
| 1991 |
Huang XM, Johnson MP, Nichols DE. Reduction in brain serotonin markers by alpha-ethyltryptamine (Monase). European Journal of Pharmacology. 200: 187-90. PMID 1722753 DOI: 10.1016/0014-2999(91)90686-K |
0.344 |
|
| 1991 |
Johnson MP, Nichols DE. Combined administration of a non-neurotoxic 3,4-methylenedioxymethamphetamine analogue with amphetamine produces serotonin neurotoxicity in rats. Neuropharmacology. 30: 819-22. PMID 1717873 DOI: 10.1016/0028-3908(91)90192-E |
0.397 |
|
| 1991 |
Lovenberg TW, Roth RH, Nichols DE, Mailman RB. D1 dopamine receptors of NS20Y neuroblastoma cells are functionally similar to rat striatal D1 receptors. Journal of Neurochemistry. 57: 1563-9. PMID 1717649 DOI: 10.1111/J.1471-4159.1991.Tb06352.X |
0.413 |
|
| 1991 |
Johnson MP, Conarty PF, Nichols DE. [3H]monoamine releasing and uptake inhibition properties of 3,4-methylenedioxymethamphetamine and p-chloroamphetamine analogues. European Journal of Pharmacology. 200: 9-16. PMID 1685125 DOI: 10.1016/0014-2999(91)90659-E |
0.436 |
|
| 1991 |
Darney KJ, Lewis MH, Brewster WK, Nichols DE, Mailman RB. Behavioral effects in the rat of dihydrexidine, a high-potency, full-efficacy D1 dopamine receptor agonist. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 5: 187-95. PMID 1684499 |
0.366 |
|
| 1991 |
Elsworth JD, Lawrence MS, Roth RH, Taylor JR, Mailman RB, Nichols DE, Lewis MH, Redmond DE. D1 and D2 dopamine receptors independently regulate spontaneous blink rate in the vervet monkey. The Journal of Pharmacology and Experimental Therapeutics. 259: 595-600. PMID 1682479 |
0.349 |
|
| 1991 |
Lovenberg TW, Nichols DE, Nestler EJ, Roth RH, Mailman RB. Guanine nucleotide binding proteins and the regulation of cyclic AMP synthesis in NS20Y neuroblastoma cells: role of D1 dopamine and muscarinic receptors. Brain Research. 556: 101-7. PMID 1682005 DOI: 10.1016/0006-8993(91)90552-7 |
0.393 |
|
| 1991 |
Taylor JR, Lawrence MS, Redmond DE, Elsworth JD, Roth RH, Nichols DE, Mailman RB. Dihydrexidine, a full dopamine D1 agonist, reduces MPTP-induced parkinsonism in monkeys. European Journal of Pharmacology. 199: 389-91. PMID 1680717 DOI: 10.1016/0014-2999(91)90508-N |
0.401 |
|
| 1991 |
Steele TD, Brewster WK, Johnson MP, Nichols DE, Yim GK. Assessment of the role of alpha-methylepinine in the neurotoxicity of MDMA. Pharmacology, Biochemistry, and Behavior. 38: 345-51. PMID 1676172 DOI: 10.1016/0091-3057(91)90289-E |
0.771 |
|
| 1991 |
Persons PE, Mayer JP, Nichols DE, Cassady JM, Smalstig EB, Clemens JA. Preliminary evaluation of 4-(2-N,N-dialkylaminoethyl)indoles as potential dopamine agonists European Journal of Medicinal Chemistry. 26: 473-475. DOI: 10.1016/0223-5234(91)90110-9 |
0.357 |
|
| 1990 |
Johnson MP, Mathis CA, Shulgin AT, Hoffman AJ, Nichols DE. [125I]-2-(2,5-dimethoxy-4-iodophenyl)aminoethane ([125I]-2C-I) as a label for the 5-HT2 receptor in rat frontal cortex. Pharmacology, Biochemistry, and Behavior. 35: 211-7. PMID 2315361 DOI: 10.1016/0091-3057(90)90228-A |
0.441 |
|
| 1990 |
Johnson MP, Nichols DE. Comparative serotonin neurotoxicity of the stereoisomers of fenfluramine and norfenfluramine. Pharmacology, Biochemistry, and Behavior. 36: 105-9. PMID 2140899 DOI: 10.1016/0091-3057(90)90133-3 |
0.391 |
|
| 1990 |
Johnson MP, Huang XM, Oberlender R, Nash JF, Nichols DE. Behavioral, biochemical and neurotoxicological actions of the alpha-ethyl homologue of p-chloroamphetamine. European Journal of Pharmacology. 191: 1-10. PMID 1982656 DOI: 10.1016/0014-2999(90)94090-K |
0.386 |
|
| 1990 |
Nichols DE, Oberlender R. Structure-activity relationships of MDMA and related compounds: a new class of psychoactive drugs? Annals of the New York Academy of Sciences. 600: 613-23; discussion 6. PMID 1979214 DOI: 10.1111/J.1749-6632.1990.Tb16914.X |
0.319 |
|
| 1990 |
Brewster WK, Nichols DE, Riggs RM, Mottola DM, Lovenberg TW, Lewis MH, Mailman RB. trans-10,11-dihydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine: a highly potent selective dopamine D1 full agonist. Journal of Medicinal Chemistry. 33: 1756-64. PMID 1971308 DOI: 10.1021/Jm00168A034 |
0.854 |
|
| 1990 |
Nichols DE, Brewster WK, Johnson MP, Oberlender R, Riggs RM. Nonneurotoxic tetralin and indan analogues of 3,4-(methylenedioxy)amphetamine (MDA). Journal of Medicinal Chemistry. 33: 703-10. PMID 1967651 DOI: 10.1021/Jm00164A037 |
0.804 |
|
| 1990 |
Kohli JD, Glock D, Brewster WK, Knoerzer T, Nichols DE. A new potent and selective DA1 (vascular) dopamine receptor agonist European Journal of Pharmacology. 183: 1287. DOI: 10.1016/0014-2999(90)94395-E |
0.832 |
|
| 1989 |
Nichols DE, Oberlender R, Burris K, Hoffman AJ, Johnson MP. Studies of dioxole ring substituted 3,4-methylenedioxyamphetamine (MDA) analogues. Pharmacology, Biochemistry, and Behavior. 34: 571-6. PMID 2623014 DOI: 10.1016/0091-3057(89)90560-1 |
0.403 |
|
| 1989 |
Steele TD, Nichols DE, Yim GK. MDMA transiently alters biogenic amines and metabolites in mouse brain and heart. Pharmacology, Biochemistry, and Behavior. 34: 223-7. PMID 2576134 DOI: 10.1016/0091-3057(89)90303-1 |
0.309 |
|
| 1989 |
Lovenberg TW, Brewster WK, Mottola DM, Lee RC, Riggs RM, Nichols DE, Lewis MH, Mailman RB. Dihydrexidine, a novel selective high potency full dopamine D-1 receptor agonist. European Journal of Pharmacology. 166: 111-3. PMID 2572425 DOI: 10.1016/0014-2999(89)90690-0 |
0.846 |
|
| 1989 |
Dimpfel W, Spüler M, Nichols DE. Hallucinogenic and stimulatory amphetamine derivatives: fingerprinting DOM, DOI, DOB, MDMA, and MBDB by spectral analysis of brain field potentials in the freely moving rat (Tele-Stereo-EEG). Psychopharmacology. 98: 297-303. PMID 2568652 DOI: 10.1007/Bf00451678 |
0.362 |
|
| 1989 |
McKenna DJ, Nazarali AJ, Hoffman AJ, Nichols DE, Mathis CA, Saavedra JM. Common receptors for hallucinogens in rat brain: a comparative autoradiographic study using [125I]LSD and [125I]DOI, a new psychotomimetic radioligand. Brain Research. 476: 45-56. PMID 2536576 DOI: 10.1016/0006-8993(89)91535-7 |
0.392 |
|
| 1989 |
Johnson MP, Nichols DE. Neurotoxic effects of the alpha-ethyl homologue of MDMA following subacute administration. Pharmacology, Biochemistry, and Behavior. 33: 105-8. PMID 2476831 DOI: 10.1016/0091-3057(89)90437-1 |
0.411 |
|
| 1989 |
Mathis C, Gerdes J, Shulgin A, Hoffman A, Nichols D. Synthesis of high specific activity radiohalogenated amphetamine analogues for studies of the serotonin 5-HT2 receptor Journal of Labelled Compounds and Radiopharmaceuticals. 26: 130-132. DOI: 10.1002/JLCR.2580260157 |
0.495 |
|
| 1988 |
Nichols DE, Lloyd DH, Johnson MP, Hoffman AJ. Synthesis and serotonin receptor affinities of a series of enantiomers of alpha-methyltryptamines: evidence for the binding conformation of tryptamines at serotonin 5-HT1B receptors. Journal of Medicinal Chemistry. 31: 1406-12. PMID 3385733 DOI: 10.1021/Jm00402A026 |
0.512 |
|
| 1988 |
Oberlender R, Nichols DE. Drug discrimination studies with MDMA and amphetamine. Psychopharmacology. 95: 71-6. PMID 2898791 DOI: 10.1007/Bf00212770 |
0.315 |
|
| 1987 |
Riggs RM, Nichols DE, Foreman MM, Truex LL. Evaluation of isomeric 4-(chlorohydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines as dopamine D-1 antagonists. Journal of Medicinal Chemistry. 30: 1887-91. PMID 3656362 DOI: 10.1021/Jm00393A033 |
0.481 |
|
| 1987 |
Johnson MP, Hoffman AJ, Nichols DE, Mathis CA. Binding to the serotonin 5-HT2 receptor by the enantiomers of 125I-DOI. Neuropharmacology. 26: 1803-6. PMID 3437942 DOI: 10.1016/0028-3908(87)90138-9 |
0.497 |
|
| 1987 |
Riggs RM, McKenzie AT, Byrn SR, Nichols DE, Foreman MM, Truex LL. Effect of beta-alkyl substitution on D-1 dopamine agonist activity: absolute configuration of beta-methyldopamine. Journal of Medicinal Chemistry. 30: 1914-8. PMID 3309317 DOI: 10.1021/Jm00393A039 |
0.323 |
|
| 1987 |
Riggs RM, Nichols DE, Foreman MM, Truex LL, Glock D, Kohli JD. Specific dopamine D-1 and DA1 properties of 4-(mono- and -dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline and its tetrahydrothieno[2,3-c]pyridine analogue. Journal of Medicinal Chemistry. 30: 1454-8. PMID 2956423 DOI: 10.1021/Jm00391A029 |
0.48 |
|
| 1987 |
Ricaurte GA, Finnegan KF, Nichols DE, DeLanney LE, Irwin I, Langston JW. 3,4-Methylenedioxyethylamphetamine (MDE), a novel analogue of MDMA, produces long-lasting depletion of serotonin in the rat brain. European Journal of Pharmacology. 137: 265-8. PMID 2886355 DOI: 10.1016/0014-2999(87)90233-0 |
0.38 |
|
| 1987 |
Steele TD, Nichols DE, Yim GK. Stereochemical effects of 3,4-methylenedioxymethamphetamine (MDMA) and related amphetamine derivatives on inhibition of uptake of [3H]monoamines into synaptosomes from different regions of rat brain. Biochemical Pharmacology. 36: 2297-303. PMID 2886126 DOI: 10.1016/0006-2952(87)90594-6 |
0.367 |
|
| 1986 |
Nichols DE. Studies of the relationship between molecular structure and hallucinogenic activity. Pharmacology, Biochemistry, and Behavior. 24: 335-40. PMID 3952123 DOI: 10.1016/0091-3057(86)90362-X |
0.361 |
|
| 1986 |
Nichols DE, Hoffman AJ, Oberlender RA, Riggs RM. Synthesis and evaluation of 2,3-dihydrobenzofuran analogues of the hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane: drug discrimination studies in rats. Journal of Medicinal Chemistry. 29: 302-4. PMID 3950910 DOI: 10.1021/Jm00152A022 |
0.382 |
|
| 1986 |
Hoffman AJ, Maxwell DM, Nichols DE. A simple organ bath for electrical stimulation and superfusion of rat brain slices. Journal of Pharmacological Methods. 16: 185-99. PMID 3784567 DOI: 10.1016/0160-5402(86)90041-0 |
0.317 |
|
| 1986 |
Nichols DE, Hoffman AJ, Oberlender RA, Jacob P, Shulgin AT. Derivatives of 1-(1,3-benzodioxol-5-yl)-2-butanamine: representatives of a novel therapeutic class. Journal of Medicinal Chemistry. 29: 2009-15. PMID 3761319 DOI: 10.1021/Jm00160A035 |
0.343 |
|
| 1986 |
Johnson MP, Hoffman AJ, Nichols DE. Effects of the enantiomers of MDA, MDMA and related analogues on [3H]serotonin and [3H]dopamine release from superfused rat brain slices. European Journal of Pharmacology. 132: 269-76. PMID 2880735 DOI: 10.1016/0014-2999(86)90615-1 |
0.394 |
|
| 1986 |
Lloyd DH, Nichols DE. Nickel boride/hydrazine hydrate reduction of aromatic and aliphatic nitro compounds. Synthesis of 4-(benzyloxy)indole and .alpha.-alkyltryptamines The Journal of Organic Chemistry. 51: 4294-4295. DOI: 10.1021/JO00372A037 |
0.307 |
|
| 1985 |
Hoffman AJ, Nichols DE. Synthesis and LSD-like discriminative stimulus properties in a series of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives. Journal of Medicinal Chemistry. 28: 1252-5. PMID 4032428 DOI: 10.1021/Jm00147A022 |
0.358 |
|
| 1984 |
Oberlender RA, Kothari PJ, Nichols DE, Zabik JE. Substituent branching in phenethylamine-type hallucinogens: a comparison of 1-[2,5-dimethoxy-4-(2-butyl)phenyl]-2-aminopropane and 1-[2,5-dimethoxy-4-(2-methylpropyl)phenyl]-2-aminopropane. Journal of Medicinal Chemistry. 27: 788-92. PMID 6737421 DOI: 10.1021/Jm00372A015 |
0.414 |
|
| 1984 |
Nichols DE, Jacob JN, Hoffman AJ, Kohli JD, Glock D. C(2)-Methylation abolishes DA1 dopamine agonist activity of 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (6,7-ADTN): steric intolerance by the receptor. Journal of Medicinal Chemistry. 27: 1701-5. PMID 6502600 DOI: 10.1021/Jm00378A029 |
0.498 |
|
| 1984 |
Nichols DE, Schooler D, Yeung MC, Oberlender RA, Zabik JE. Unreliability of the rat stomach fundus as a predictor of hallucinogenic activity in substituted phenethylamines. Life Sciences. 35: 1343-8. PMID 6482656 DOI: 10.1016/0024-3205(84)90390-4 |
0.386 |
|
| 1984 |
Nichols DE, Jadhav KP, Oberlender RA, Zabik JE, Bossart JF, Hamada A, Miller DD. Synthesis and evaluation of substituted 2-phenylcyclobutylamines as analogues of hallucinogenic phenethylamines: lack of LSD-like biological activity. Journal of Medicinal Chemistry. 27: 1108-11. PMID 6471065 DOI: 10.1002/Chin.198505188 |
0.326 |
|
| 1984 |
Clemens JA, Fuller RW, Phebus LA, Smalstig EB, Hynes MD, Cassady JM, Nichols DE, Kelly E, Persons P. Stimulation of presynaptic dopamine autoreceptors by 4-(2-di-n-propylaminoethyl) indole (DPAI). Life Sciences. 34: 1015-22. PMID 6422174 DOI: 10.1016/0024-3205(84)90014-6 |
0.387 |
|
| 1982 |
Grosso JA, Nichols DE, Kohli JD, Glock D. Synthesis of 2-(alkylamino)-5,6- and -6,7-dihydroxy-3,4-dihydroquinazolines and evaluation as potential dopamine agonists. Journal of Medicinal Chemistry. 25: 703-8. PMID 7097723 DOI: 10.1021/Jm00348A018 |
0.413 |
|
| 1982 |
Nichols DE, Lloyd DH, Hoffman AJ, Nichols MB, Yim GK. Effects of certain hallucinogenic amphetamine analogues on the release of [3H]serotonin from rat brain synaptosomes. Journal of Medicinal Chemistry. 25: 530-5. PMID 7086839 DOI: 10.1021/Jm00347A010 |
0.332 |
|
| 1982 |
Jacob JN, Nichols DE. Isomeric cyclopropyl ring-methylated homologues of trans-2-(2,5-dimethoxy-4-methylphenyl)cyclopropylamine, an hallucinogen analogue. Journal of Medicinal Chemistry. 25: 526-30. PMID 7086838 DOI: 10.1021/Jm00347A009 |
0.325 |
|
| 1982 |
Hathaway BA, Nichols DE, Nichols MB, Yim GK. A new, potent, conformationally restricted analogue of amphetamine: 2-amino-1,2-dihydronaphthalene. Journal of Medicinal Chemistry. 25: 535-8. PMID 6123601 DOI: 10.1021/Jm00347A011 |
0.333 |
|
| 1982 |
Nichols DE, Lloyd DH, Hoffman AJ, Nichols MB, Yim GKW. Effects Of Certain Hallucinogenic Amphetamine Analogs On The Release Of (3H)-Serotonin From Rat Brain Synaptosomes Cheminform. 13. DOI: 10.1002/Chin.198241197 |
0.301 |
|
| 1982 |
Hathaway BA, Nichols DE, Nichols MB, Yim GKW. A New, Potent, Conformationally-Restricted Analog Of Amphetamine: 2-Amino-1,2-Dihydronaphthalene Cheminform. 13. DOI: 10.1002/Chin.198241176 |
0.325 |
|
| 1981 |
Jacob JN, Nichols DE, Kohli JD, Glock D. Dopamine agonist properties of N-alkyl-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines. Journal of Medicinal Chemistry. 24: 1013-5. PMID 7328594 DOI: 10.1021/Jm00140A021 |
0.354 |
|
| 1981 |
Kothari PJ, Hathaway BA, Nichols DE, Yim GK. Synthesis and serotonin-like activity of 2-amino-5,8-dimethoxy-6-methyl-1,2-dihydronaphthalene. Journal of Medicinal Chemistry. 24: 882-4. PMID 7277398 DOI: 10.1021/Jm00139A022 |
0.344 |
|
| 1980 |
Grosso JA, Nichols DE, Nichols MB, Yim GK. Synthesis and adrenergic blocking effects of 2-(alkylamino)-3,4-dihydroquinazolines. Journal of Medicinal Chemistry. 23: 1261-4. PMID 7452680 DOI: 10.1021/Jm00185A026 |
0.319 |
|
| 1979 |
Ginos JZ, Stevens JM, Nichols DE. Structure--activity relationships of n-substituted dopamine and 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene analogues: behavioral effects in lesioned and reserpinized mice. Journal of Medicinal Chemistry. 22: 1323-9. PMID 574901 DOI: 10.1021/Jm00197A009 |
0.333 |
|
| 1979 |
Nichols DE, Kostuba LJ. Steric effects of substituents on phenethylamine hallucinogens. 3,4-(Methylenedioxy)amphetamine analogues alkylated on the dioxole ring. Journal of Medicinal Chemistry. 22: 1264-7. PMID 513074 DOI: 10.1021/Jm00196A022 |
0.349 |
|
| 1979 |
Kohli JD, Goldberg LI, Nichols DE. Dopamine vascular actions of N-substituted derivatives of 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (ADTN). European Journal of Pharmacology. 56: 39-44. PMID 467513 DOI: 10.1016/0014-2999(79)90430-8 |
0.345 |
|
| 1979 |
Nichols DE, Woodard R, Hathaway BA, Lowy MT, Yom KW. Resolution and absolute configuration of trans-2-(2,5-dimethoxy-4-methylphenyl)cyclopropylamine, a potent hallucinogen analogue. Journal of Medicinal Chemistry. 22: 458-60. PMID 430485 DOI: 10.1021/Jm00190A021 |
0.371 |
|
| 1978 |
Nichols DE, Pfister WR, Yim GK. LSD and phenethylamine hallucinogens: new structural analogy and implications for receptor geometry. Life Sciences. 22: 2165-70. PMID 672453 DOI: 10.1016/0024-3205(78)90567-2 |
0.403 |
|
| 1978 |
Nichols DE, Toth JE, Kohli JD, Kotake CK. 2,3-Dihydroxy-9-amino-9,10-dihydrophenanthrene, a rigid congener of dopamine and isoapomorphine. Journal of Medicinal Chemistry. 21: 395-8. PMID 650669 DOI: 10.1021/Jm00202A017 |
0.392 |
|
| 1978 |
Nichols DE, Weintraub HJ, Pfister WR, Yim GK. The use of rigid analogues to probe hallucinogen receptors. Nida Research Monograph. 70-83. PMID 101889 |
0.321 |
|
| 1977 |
Nichols DE, Shulgin AT, Dyer DC. Directional lipophilic character in a series of psychotomimetic phenethylamine derivatives. Life Sciences. 21: 569-75. PMID 904435 DOI: 10.1016/0024-3205(77)90099-6 |
0.406 |
|
| 1977 |
Nichols DE, Dyer DC. Lipophilicity and serotonin agonist activity in a series of 4-substituted mescaline analogues. Journal of Medicinal Chemistry. 20: 299-301. PMID 836502 DOI: 10.1021/Jm00212A022 |
0.433 |
|
| 1976 |
Nichols DE. Structural correlation between apomorphine and LSD: involvement of dopamine as well as serotonin in the actions of hallucinogens. Journal of Theoretical Biology. 59: 167-77. PMID 7711 DOI: 10.1016/S0022-5193(76)80030-6 |
0.453 |
|
| 1975 |
Barfknecht CF, Nichols DE. Correlation of psychotomimetic activity of phenethylamines and amphetamines with 1-octanol-water partition coefficients. Journal of Medicinal Chemistry. 18: 208-10. PMID 1120990 DOI: 10.1002/Chin.197525187 |
0.602 |
|
| 1975 |
Ilhan M, Nichols DE, Long JP, Cannon JG. Apomorphine-like effect of an aminotetralin on the linguomandibular reflex of the cat. European Journal of Pharmacology. 33: 61-4. PMID 240731 DOI: 10.1016/0014-2999(75)90138-7 |
0.509 |
|
| 1974 |
Cheng HC, Long JP, Nichols DE, Barfknecht CF, Rusterholz DB. Effects of rigid amphetamine analogs on vascular strips: studies of 2-aminotetrahydronaphthalene and 2-aminoindan derivatives. Archives Internationales De Pharmacodynamie Et De ThéRapie. 208: 264-73. PMID 4851775 |
0.58 |
|
| 1974 |
Cheng HC, Long JP, Nichols DE, Barfknecht CF. Effects of psychotomimetics on vascular strips: studies of methoxylated amphetamines and optical isomers of 2,5-dimethoxy-4-methylamphetamine and 2,5-dimethoxy-4-bromoamphetamine. The Journal of Pharmacology and Experimental Therapeutics. 188: 114-23. PMID 4809263 |
0.552 |
|
| 1974 |
Nichols DE, Barfknecht CF, Long JP, Standridge RT, Howell HG, Partyka RA, Dyer DC. Potential psychotomimetics. 2. Rigid analogs of 2,5-dimethoxy-4-methylphenylisopropylamine (DOM, STP). Journal of Medicinal Chemistry. 17: 161-6. PMID 4809251 DOI: 10.1021/Jm00248A004 |
0.608 |
|
| 1974 |
Cheng HC, Long JP, Nichols DE, Barfknecht CF. Effects of para-methoxyamphetamine (PMA) on the cardiovascular system of the dog. Archives Internationales De Pharmacodynamie Et De ThéRapie. 212: 83-8. PMID 4455128 |
0.535 |
|
| 1974 |
NICHOLS DE, BARFKNECHT CF, LONG JP, STANDRIDGE RT, HOWELL HG, PARTYKA RA, DYER DC. ChemInform Abstract: POTENTIAL PSYCHOTOMIMETICS PART 2, RIGID ANALOGS OF 2,5-DIMETHOXY-4-METHYLPHENYLISOPROPYLAMINE (DOM,STP) Chemischer Informationsdienst. 5: no-no. DOI: 10.1002/Chin.197425249 |
0.61 |
|
| 1973 |
Dyer DC, Nichols DE, Rusterholz DB, Barfknecht CF. Comparative effects of stereoisomers of psychotomimetic phenylisopropylamines. Life Sciences. 13: 885-96. PMID 4766265 DOI: 10.1016/0024-3205(73)90079-9 |
0.635 |
|
| 1973 |
Barfknecht CF, Nichols DE, Rusterholz DB, Long JP, Engelbrecht JA, Beaton JM, Bradley RJ, Dyer DC. Potential psychotomimetics. 2-Amino-1,2,3,4-tetrahydronaphthalene analogs. Journal of Medicinal Chemistry. 16: 804-8. PMID 4725926 DOI: 10.1002/Chin.197342259 |
0.594 |
|
| 1973 |
Cheng HC, Long JP, Barfknecht CF, Nichols DE. Cardiovascular effects of 2, 5-dimethoxy-4-methylamphetamine (DOM, STP). The Journal of Pharmacology and Experimental Therapeutics. 186: 345-54. PMID 4719787 |
0.539 |
|
| 1973 |
Nichols DE, Barfknecht CF, Rusterholz DB, Benington F, Morin RD. Asymmetric synthesis of psychotomimetic phenylisopropylamines. Journal of Medicinal Chemistry. 16: 480-3. PMID 4718460 DOI: 10.1021/Jm00263A013 |
0.607 |
|
| 1973 |
Nichols DE, Barfknecht CF. 1-Methyl-3-piperidone and 1-methyl-3-pyrrolidone derivatives from a dieckmann reaction Journal of Heterocyclic Chemistry. 10: 339-341. DOI: 10.1002/Jhet.5570100311 |
0.557 |
|
| 1973 |
NICHOLS DE, BARFKNECHT CF. ChemInform Abstract: 1-METHYL-3-PIPERIDONE AND 1-METHYL-3-PYRROLIDONE DERIVATIVES FROM A DIECKMANN REACTION Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/chin.197345340 |
0.546 |
|
| 1972 |
Engelbrecht JA, Long JP, Nichols DE, Barfknecht CF. Pharmacologic evaluation of 3,4-dimethoxyphenylpropenes and 3,4-dimethoxyphenylpropanediols. Archives Internationales De Pharmacodynamie Et De ThéRapie. 199: 226-44. PMID 5070643 |
0.554 |
|
| 1972 |
Barfknecht CF, Nichols DE. Effects of S-(+)- and R-(-)-3,4,dimethoxyphenylisopropylamines in the rat. Journal of Medicinal Chemistry. 15: 109-10. PMID 5007083 DOI: 10.1021/Jm00271A037 |
0.595 |
|
| 1971 |
Barfknecht CF, Nichols DE. Potential psychotomimetics. Bromomethoxyamphetamines. Journal of Medicinal Chemistry. 14: 370-2. PMID 5553756 DOI: 10.1021/Jm00286A026 |
0.573 |
|
| 1971 |
Antun F, Smythies JR, Benington F, Morin RD, Barfknecht CF, Nichols DE. Native fluorescence and hallucinogenic potency of some amphetamines. Experientia. 27: 62-3. PMID 5549244 DOI: 10.1007/BF02137743 |
0.559 |
|
| 1971 |
Barfknecht CF, Smith RV, Nichols DE, Leseney JL, Long JP, Engelbrecht JA. Chemistry and pharmacological evaluation of 1-phenyl-2-propanols and 1-phenyl-2-propanones. Journal of Pharmaceutical Sciences. 60: 799-801. PMID 5125790 DOI: 10.1002/Jps.2600600533 |
0.598 |
|
| 1971 |
BARFKNECHT CF, SMITH RV, NICHOLS DE, LESENEY JL, LONG JP, ENGELBRECHT JA. ChemInform Abstract: CHEMIE UND PHARMAKOLOGISCHE BEWERTUNG VON 1-PHENYLPROPANOLEN-(2)(I) UND 1-PHENYLPROPANONEN-(2)(II) Chemischer Informationsdienst. Organische Chemie. 2: no-no. DOI: 10.1002/Chin.197136272 |
0.522 |
|
| Show low-probability matches. |
