Gavin MacBeath, PhD - Publications

Affiliations: 
Chemistry and Chemical Biology Harvard University, Cambridge, MA, United States 
Area:
Protein Systems
Website:
http://macbeath.hms.harvard.edu/

56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Curley MD, Sabnis GJ, Wille L, Adiwijaya BS, Garcia G, Moyo V, Kazi AA, Brodie A, MacBeath G. Seribantumab, an anti-ERBB3 antibody, delays the onset of resistance and restores sensitivity to letrozole in an estrogen receptor-positive breast cancer model. Molecular Cancer Therapeutics. PMID 26310543 DOI: 10.1158/1535-7163.MCT-15-0169  1
2015 Qian G, Jiang N, Wang D, Newman S, Kim S, Chen Z, Garcia G, MacBeath G, Shin DM, Khuri FR, Chen ZG, Saba NF. Heregulin and HER3 are prognostic biomarkers in oropharyngeal squamous cell carcinoma. Cancer. PMID 26195293 DOI: 10.1002/cncr.29549  1
2015 Yarar D, Lahdenranta J, Kubasek W, Nielsen UB, MacBeath G. Heregulin-ErbB3-Driven Tumor Growth Persists in PI3 Kinase Mutant Cancer Cells. Molecular Cancer Therapeutics. PMID 26116360 DOI: 10.1158/1535-7163.MCT-15-0075  1
2014 Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, MacBeath G. A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. Cell. 159: 844-56. PMID 25417160 DOI: 10.1016/j.cell.2014.10.032  1
2014 AlQuraishi M, Koytiger G, Jenney A, MacBeath G, Sorger PK. A multiscale statistical mechanical framework integrates biophysical and genomic data to assemble cancer networks. Nature Genetics. 46: 1363-71. PMID 25362484 DOI: 10.1038/ng.3138  1
2014 Yi CR, Allen JE, Russo B, Lee SY, Heindl JE, Baxt LA, Herrera BB, Kahoud E, MacBeath G, Goldberg MB. Systematic analysis of bacterial effector-postsynaptic density 95/disc large/zonula occludens-1 (PDZ) domain interactions demonstrates Shigella OspE protein promotes protein kinase C activation via PDLIM proteins. The Journal of Biological Chemistry. 289: 30101-13. PMID 25124035 DOI: 10.1074/jbc.M114.595868  1
2014 Jiang N, Wang D, Hu Z, Shin HJ, Qian G, Rahman MA, Zhang H, Amin AR, Nannapaneni S, Wang X, Chen Z, Garcia G, MacBeath G, Shin DM, Khuri FR, et al. Combination of anti-HER3 antibody MM-121/SAR256212 and cetuximab inhibits tumor growth in preclinical models of head and neck squamous cell carcinoma. Molecular Cancer Therapeutics. 13: 1826-36. PMID 24748655 DOI: 10.1158/1535-7163.MCT-13-1093  1
2013 Onsum MD, Geretti E, Paragas V, Kudla AJ, Moulis SP, Luus L, Wickham TJ, McDonagh CF, Macbeath G, Hendriks BS. Single-cell quantitative HER2 measurement identifies heterogeneity and distinct subgroups within traditionally defined HER2-positive patients. The American Journal of Pathology. 183: 1446-60. PMID 24035511 DOI: 10.1016/j.ajpath.2013.07.015  1
2013 Wagner JP, Wolf-Yadlin A, Sevecka M, Grenier JK, Root DE, Lauffenburger DA, MacBeath G. Receptor tyrosine kinases fall into distinct classes based on their inferred signaling networks. Science Signaling. 6: ra58. PMID 23861540 DOI: 10.1126/scisignal.2003994  1
2013 Gujral TS, Karp ES, Chan M, Chang BH, MacBeath G. Family-wide investigation of PDZ domain-mediated protein-protein interactions implicates β-catenin in maintaining the integrity of tight junctions. Chemistry & Biology. 20: 816-27. PMID 23790492 DOI: 10.1016/j.chembiol.2013.04.021  1
2013 Kaushansky A, Ye AS, Austin LS, Mikolajczak SA, Vaughan AM, Camargo N, Metzger PG, Douglass AN, MacBeath G, Kappe SH. Suppression of host p53 is critical for Plasmodium liver-stage infection. Cell Reports. 3: 630-7. PMID 23478020 DOI: 10.1016/j.celrep.2013.02.010  1
2013 Koytiger G, Kaushansky A, Gordus A, Rush J, Sorger PK, MacBeath G. Phosphotyrosine signaling proteins that drive oncogenesis tend to be highly interconnected. Molecular & Cellular Proteomics : McP. 12: 1204-13. PMID 23358503 DOI: 10.1074/mcp.M112.025858  1
2013 Gujral TS, Karp RL, Finski A, Chan M, Schwartz PE, MacBeath G, Sorger P. Profiling phospho-signaling networks in breast cancer using reverse-phase protein arrays. Oncogene. 32: 3470-6. PMID 22945653 DOI: 10.1038/onc.2012.378  1
2012 Lee MJ, Ye AS, Gardino AK, Heijink AM, Sorger PK, MacBeath G, Yaffe MB. Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell. 149: 780-94. PMID 22579283 DOI: 10.1016/j.cell.2012.03.031  1
2012 Beyer EM, MacBeath G. Cross-talk between receptor tyrosine kinase and tumor necrosis factor-α signaling networks regulates apoptosis but not proliferation. Molecular & Cellular Proteomics : McP. 11: M111.013292. PMID 22323825 DOI: 10.1074/mcp.M111.013292  1
2012 Luckert K, Gujral TS, Chan M, Sevecka M, Joos TO, Sorger PK, Macbeath G, Pötz O. A dual array-based approach to assess the abundance and posttranslational modification state of signaling proteins. Science Signaling. 5: pl1. PMID 22234610 DOI: 10.1126/scisignal.2002372  1
2012 Luckert K, Gujral TS, Chan M, Sevecka M, Joos TO, Sorger PK, MacBeath G, Pötz O. A correction to the protocol titled: "A dual array-based approach to assess the abundance and posttranslational modification state of signaling proteins" by K. Luckert, T. S. Gujral, M. Chan, T. O. Joos, P. K. Sorger, G. MacBeath, O. Pötz Science Signaling. 5. DOI: 10.1126/scisignal.5238er5  1
2011 Chang BH, Gujral TS, Karp ES, BuKhalid R, Grantcharova VP, MacBeath G. A systematic family-wide investigation reveals that ~30% of mammalian PDZ domains engage in PDZ-PDZ interactions. Chemistry & Biology. 18: 1143-52. PMID 21944753 DOI: 10.1016/j.chembiol.2011.06.013  1
2011 Jung AS, Kaushansky A, Macbeath G, Kaushansky K. Tensin2 is a novel mediator in thrombopoietin (TPO)-induced cellular proliferation by promoting Akt signaling. Cell Cycle (Georgetown, Tex.). 10: 1838-44. PMID 21527831 DOI: 10.4161/cc.10.11.15776  1
2011 Knickerbocker T, MacBeath G. Detecting and quantifying multiple proteins in clinical samples in high-throughput using antibody microarrays. Methods in Molecular Biology (Clifton, N.J.). 723: 3-13. PMID 21370055 DOI: 10.1007/978-1-61779-043-0_1  1
2011 Sevecka M, Wolf-Yadlin A, MacBeath G. Lysate microarrays enable high-throughput, quantitative investigations of cellular signaling. Molecular & Cellular Proteomics : McP. 10: M110.005363. PMID 21296872 DOI: 10.1074/mcp.M110.005363  1
2011 Krall JA, Beyer EM, MacBeath G. High- and low-affinity epidermal growth factor receptor-ligand interactions activate distinct signaling pathways. Plos One. 6: e15945. PMID 21264347 DOI: 10.1371/journal.pone.0015945  1
2010 Boettcher JP, Kirchner M, Churin Y, Kaushansky A, Pompaiah M, Thorn H, Brinkmann V, Macbeath G, Meyer TF. Tyrosine-phosphorylated caveolin-1 blocks bacterial uptake by inducing Vav2-RhoA-mediated cytoskeletal rearrangements. Plos Biology. 8. PMID 20808760 DOI: 10.1371/journal.pbio.1000457  1
2010 Mehlitz A, Banhart S, Mäurer AP, Kaushansky A, Gordus AG, Zielecki J, Macbeath G, Meyer TF. Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1. The Journal of Cell Biology. 190: 143-57. PMID 20624904 DOI: 10.1083/jcb.200909095  1
2010 Gujral TS, MacBeath G. A system-wide investigation of the dynamics of Wnt signaling reveals novel phases of transcriptional regulation. Plos One. 5: e10024. PMID 20383323 DOI: 10.1371/journal.pone.0010024  1
2010 Kaushansky A, Allen JE, Gordus A, Stiffler MA, Karp ES, Chang BH, MacBeath G. Quantifying protein-protein interactions in high throughput using protein domain microarrays. Nature Protocols. 5: 773-90. PMID 20360771 DOI: 10.1038/nprot.2010.36  1
2010 Shalek AK, Robinson JT, Karp ES, Lee JS, Ahn DR, Yoon MH, Sutton A, Jorgolli M, Gertner RS, Gujral TS, MacBeath G, Yang EG, Park H. Vertical silicon nanowires as a universal platform for delivering biomolecules into living cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 1870-5. PMID 20080678 DOI: 10.1073/pnas.0909350107  1
2009 MacBeath G, Saghatelian A. The promise and challenge of '-omic' approaches. Current Opinion in Chemical Biology. 13: 501-2. PMID 19853495 DOI: 10.1016/j.cbpa.2009.10.008  1
2009 Gujral TS, MacBeath G. Emerging miniaturized proteomic technologies to study cell signaling in clinical samples. Science Signaling. 2: pe65. PMID 19843955 DOI: 10.1126/scisignal.293pe64  1
2009 Wolf-Yadlin A, Sevecka M, MacBeath G. Dissecting protein function and signaling using protein microarrays. Current Opinion in Chemical Biology. 13: 398-405. PMID 19660979 DOI: 10.1016/j.cbpa.2009.06.027  1
2009 Gordus A, Krall JA, Beyer EM, Kaushansky A, Wolf-Yadlin A, Sevecka M, Chang BH, Rush J, MacBeath G. Linear combinations of docking affinities explain quantitative differences in RTK signaling. Molecular Systems Biology. 5: 235. PMID 19156127 DOI: 10.1038/msb.2008.72  1
2008 Kaushansky A, Gordus A, Budnik BA, Lane WS, Rush J, MacBeath G. System-wide investigation of ErbB4 reveals 19 sites of Tyr phosphorylation that are unusually selective in their recruitment properties. Chemistry & Biology. 15: 808-17. PMID 18721752 DOI: 10.1016/j.chembiol.2008.07.006  1
2008 Chen JR, Chang BH, Allen JE, Stiffler MA, MacBeath G. Predicting PDZ domain-peptide interactions from primary sequences. Nature Biotechnology. 26: 1041-5. PMID 18711339 DOI: 10.1038/nbt.1489  1
2008 Kaushansky A, Gordus A, Chang B, Rush J, MacBeath G. A quantitative study of the recruitment potential of all intracellular tyrosine residues on EGFR, FGFR1 and IGF1R. Molecular Biosystems. 4: 643-53. PMID 18493663 DOI: 10.1039/b801018h  1
2008 Chen JR, Chang BH, Allen JE, Stiffler MA, MacBeath G. Predicting PDZ domain-peptide interactions from primary sequences (Nature Biotechnology (2008) 26, (1041-1045)) Nature Biotechnology. 26: 1193. DOI: 10.1038/nbt1008-1193c  1
2007 Stiffler MA, Chen JR, Grantcharova VP, Lei Y, Fuchs D, Allen JE, Zaslavskaia LA, MacBeath G. PDZ domain binding selectivity is optimized across the mouse proteome. Science (New York, N.Y.). 317: 364-9. PMID 17641200 DOI: 10.1126/science.1144592  1
2007 Knickerbocker T, Chen JR, Thadhani R, MacBeath G. An integrated approach to prognosis using protein microarrays and nonparametric methods. Molecular Systems Biology. 3: 123. PMID 17593911 DOI: 10.1038/msb4100167  1
2006 Albeck JG, MacBeath G, White FM, Sorger PK, Lauffenburger DA, Gaudet S. Collecting and organizing systematic sets of protein data. Nature Reviews. Molecular Cell Biology. 7: 803-12. PMID 17057751 DOI: 10.1038/nrm2042  1
2006 Gordus A, MacBeath G. Circumventing the problems caused by protein diversity in microarrays: implications for protein interaction networks. Journal of the American Chemical Society. 128: 13668-9. PMID 17044677 DOI: 10.1021/ja065381g  1
2006 Sevecka M, MacBeath G. State-based discovery: a multidimensional screen for small-molecule modulators of EGF signaling. Nature Methods. 3: 825-31. PMID 16990815 DOI: 10.1038/nmeth931  1
2006 Stiffler MA, Grantcharova VP, Sevecka M, MacBeath G. Uncovering quantitative protein interaction networks for mouse PDZ domains using protein microarrays. Journal of the American Chemical Society. 128: 5913-22. PMID 16637659 DOI: 10.1021/ja060943h  1
2006 Jones RB, Gordus A, Krall JA, MacBeath G. A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature. 439: 168-74. PMID 16273093 DOI: 10.1038/nature04177  1
2003 Nielsen UB, Cardone MH, Sinskey AJ, MacBeath G, Sorger PK. Profiling receptor tyrosine kinase activation by using Ab microarrays. Proceedings of the National Academy of Sciences of the United States of America. 100: 9330-5. PMID 12876202 DOI: 10.1073/pnas.1633513100  1
2002 MacBeath G. Protein microarrays and proteomics. Nature Genetics. 32: 526-32. PMID 12454649 DOI: 10.1038/ng1037  1
2001 MacBeath G. Proteomics comes to the surface. Nature Biotechnology. 19: 828-9. PMID 11533639 DOI: 10.1038/nbt0901-828  1
2001 MacBeath G. Chemical genomics: what will it take and who gets to play? Genome Biology. 2: COMMENT2005. PMID 11423004  1
2000 MacBeath G, Schreiber SL. Printing proteins as microarrays for high-throughput function determination. Science (New York, N.Y.). 289: 1760-3. PMID 10976071  1
1999 MacBeath G, Koehler AN, Schreiber SL. Printing small molecules as microarrays and detecting protein-ligand interactions en masse [19] Journal of the American Chemical Society. 121: 7967-7968. DOI: 10.1021/ja991083q  1
1998 MacBeath G, Kast P, Hilvert D. Probing enzyme quaternary structure by combinatorial mutagenesis and selection. Protein Science : a Publication of the Protein Society. 7: 1757-67. PMID 10082372 DOI: 10.1002/pro.5560070810  1
1998 MacBeath G, Kast P, Hilvert D. A small, thermostable, and monofunctional chorismate mutase from the archaeon Methanococcus jannaschii. Biochemistry. 37: 10062-73. PMID 9665711 DOI: 10.1021/bi980449t  1
1998 MacBeath G, Kast P. UGA read-through artifacts--when popular gene expression systems need a pATCH. Biotechniques. 24: 789-94. PMID 9591128  1
1998 MacBeath G, Kast P, Hilvert D. Exploring sequence constraints on an interhelical turn using in vivo selection for catalytic activity. Protein Science : a Publication of the Protein Society. 7: 325-35. PMID 9521108 DOI: 10.1002/pro.5560070212  1
1998 MacBeath G, Kast P, Hilvert D. Redesigning enzyme topology by directed evolution. Science (New York, N.Y.). 279: 1958-61. PMID 9506949 DOI: 10.1126/science.279.5358.1958  1
1996 MacBeath G, Hilvert D. Hydrolytic antibodies: variations on a theme. Chemistry & Biology. 3: 433-45. PMID 8807874  1
1994 LéJohn HB, Cameron LE, Yang B, MacBeath G, Barker DS, Williams SA. Cloning and analysis of a constitutive heat shock (cognate) protein 70 gene inducible by L-glutamine. The Journal of Biological Chemistry. 269: 4513-22. PMID 8308021  1
1994 MacBeath G, Hilvert D. Monitoring catalytic activity by immunoassay: Implications for screening Journal of the American Chemical Society. 116: 6101-6106.  1
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