Samuel K. Kulp, D.V.M., Ph.D. - Publications

Affiliations: 
2001 Veterinary Biosciences Ohio State University, Columbus, Columbus, OH 
 2002-2017 Medicinal Chemistry Ohio State University, Columbus, Columbus, OH 
 2018- Pharmaceutics and Pharmaceutical Chemistry Ohio State University, Columbus, Columbus, OH 

56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Weng SC, Kashida Y, Kulp SK, Wang D, Brueggemeier RW, Shapiro CL, Chen CS. Retraction: Sensitizing Estrogen Receptor-negative Breast Cancer Cells to Tamoxifen with OSU-03012, a Novel Celecoxib-derived Phosphoinositide-dependent Protein Kinase-1/Akt Signaling Inhibitor. Molecular Cancer Therapeutics. 18: 869. PMID 30936413 DOI: 10.1158/1535-7163.MCT-19-0151  0.4
2016 Cheng H, Xie Z, Jones WP, Wei XT, Liu Z, Wang D, Kulp SK, Wang J, Coss CC, Chen CS, Marcucci G, Garzon R, Covey JM, Phelps MA, Chan KK. Preclinical Pharmacokinetics Study of R- and S-Enantiomers of the Histone Deacetylase Inhibitor, AR-42 (NSC 731438), in Rodents. The Aaps Journal. PMID 26943915 DOI: 10.1208/s12248-016-9876-3  0.4
2016 Hsu EC, Kulp SK, Huang HL, Tu HJ, Chao MW, Tseng YC, Yang MC, Salunke SB, Sullivan NJ, Chen WC, Zhang J, Teng CM, Fu WM, Sun D, Wicha MS, et al. Integrin-linked kinase as a novel molecular switch of the IL-6-NF-κB signaling loop in breast cancer. Carcinogenesis. PMID 26905583 DOI: 10.1093/carcin/bgw020  0.4
2015 Chao MW, Chu PC, Chuang HC, Shen FH, Chou CC, Hsu EC, Himmel LE, Huang HL, Tu HJ, Kulp SK, Teng CM, Chen CS. Non-epigenetic function of HDAC8 in regulating breast cancer stem cells by maintaining Notch1 protein stability. Oncotarget. PMID 26625202 DOI: 10.18632/oncotarget.6427  0.4
2015 Tseng YC, Kulp SK, Lai IL, Hsu EC, He WA, Frankhouser DE, Yan PS, Mo X, Bloomston M, Lesinski GB, Marcucci G, Guttridge DC, Bekaii-Saab T, Chen CS. Preclinical Investigation of the Novel Histone Deacetylase Inhibitor AR-42 in the Treatment of Cancer-Induced Cachexia. Journal of the National Cancer Institute. 107. PMID 26464423 DOI: 10.1093/jnci/djv274  0.4
2015 Dokla EM, Fang CS, Lai PT, Kulp SK, Serya RA, Ismail NS, Abouzid KA, Chen CS. Development of Potent Adenosine Monophosphate Activated Protein Kinase (AMPK) Activators. Chemmedchem. PMID 26350292 DOI: 10.1002/cmdc.201500371  0.4
2015 Hsu EC, Kulp SK, Huang HL, Tu HJ, Salunke SB, Sullivan NJ, Sun D, Wicha MS, Shapiro CL, Chen CS. Function of Integrin-Linked Kinase in Modulating the Stemness of IL-6-Abundant Breast Cancer Cells by Regulating γ-Secretase-Mediated Notch1 Activation in Caveolae. Neoplasia (New York, N.Y.). 17: 497-508. PMID 26152358 DOI: 10.1016/j.neo.2015.06.001  0.4
2015 Yan R, Chuang HC, Kapuriya N, Chou CC, Lai PT, Chang HW, Yang CN, Kulp SK, Chen CS. Exploitation of the ability of γ-tocopherol to facilitate membrane co-localization of Akt and PHLPP1 to develop PHLPP1-targeted Akt inhibitors. Journal of Medicinal Chemistry. 58: 2290-8. PMID 25689347 DOI: 10.1021/jm501751b  0.4
2014 Chou CC, Lee KH, Lai IL, Wang D, Mo X, Kulp SK, Shapiro CL, Chen CS. AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis. Cancer Research. 74: 4783-95. PMID 24994714 DOI: 10.1158/0008-5472.CAN-14-0135  0.4
2014 Lai IL, Chou CC, Lai PT, Fang CS, Shirley LA, Yan R, Mo X, Bloomston M, Kulp SK, Bekaii-Saab T, Chen CS. Targeting the Warburg effect with a novel glucose transporter inhibitor to overcome gemcitabine resistance in pancreatic cancer cells. Carcinogenesis. 35: 2203-13. PMID 24879635 DOI: 10.1093/carcin/bgu124  0.4
2013 Chu PC, Kulp SK, Chen CS. Insulin-like growth factor-I receptor is suppressed through transcriptional repression and mRNA destabilization by a novel energy restriction-mimetic agent. Carcinogenesis. 34: 2694-705. PMID 23864387 DOI: 10.1093/carcin/bgt251  0.4
2013 Lee SL, Chou CC, Chuang HC, Hsu EC, Chiu PC, Kulp SK, Byrd JC, Chen CS. Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines. Plos One. 8: e67149. PMID 23840605 DOI: 10.1371/journal.pone.0067149  0.4
2013 Shidaifat F, Kulp SK, Lin YC. Zeranol induces deleterious effects on the testes and the prostate gland of mature rats. Endocrine Research. 38: 232-41. PMID 23496416 DOI: 10.3109/07435800.2013.774410  0.76
2013 Berman-Booty LD, Chu PC, Thomas-Ahner JM, Bolon B, Wang D, Yang T, Clinton SK, Kulp SK, Chen CS. Suppression of prostate epithelial proliferation and intraprostatic progrowth signaling in transgenic mice by a new energy restriction-mimetic agent. Cancer Prevention Research (Philadelphia, Pa.). 6: 232-41. PMID 23275006 DOI: 10.1158/1940-6207.CAPR-12-0057  0.4
2012 Chu PC, Chuang HC, Kulp SK, Chen CS. The mRNA-stabilizing factor HuR protein is targeted by β-TrCP protein for degradation in response to glycolysis inhibition. The Journal of Biological Chemistry. 287: 43639-50. PMID 23115237 DOI: 10.1074/jbc.M112.393678  0.4
2012 Wei S, Chu PC, Chuang HC, Hung WC, Kulp SK, Chen CS. Targeting the oncogenic E3 ligase Skp2 in prostate and breast cancer cells with a novel energy restriction-mimetic agent. Plos One. 7: e47298. PMID 23071779 DOI: 10.1371/journal.pone.0047298  0.4
2012 Chuang HC, Kapuriya N, Kulp SK, Chen CS, Shapiro CL. Differential anti-proliferative activities of poly(ADP-ribose) polymerase (PARP) inhibitors in triple-negative breast cancer cells. Breast Cancer Research and Treatment. 134: 649-59. PMID 22678161 DOI: 10.1007/s10549-012-2106-5  0.4
2012 Wang D, Chu PC, Yang CN, Yan R, Chuang YC, Kulp SK, Chen CS. Development of a novel class of glucose transporter inhibitors. Journal of Medicinal Chemistry. 55: 3827-36. PMID 22468970 DOI: 10.1021/jm300015m  0.4
2011 Lee KH, Hsu EC, Guh JH, Yang HC, Wang D, Kulp SK, Shapiro CL, Chen CS. Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator. The Journal of Biological Chemistry. 286: 39247-58. PMID 21917926 DOI: 10.1074/jbc.M111.264598  0.4
2011 Lee SL, Hsu EC, Chou CC, Chuang HC, Bai LY, Kulp SK, Chen CS. Identification and characterization of a novel integrin-linked kinase inhibitor. Journal of Medicinal Chemistry. 54: 6364-74. PMID 21823616 DOI: 10.1021/jm2007744  0.4
2011 Li H, Piao L, Xu P, Ye W, Zhong S, Lin SH, Kulp SK, Mao Y, Cho Y, Lee LJ, Lee RJ, Lin YC. Liposomes containing (-)-gossypol-enriched cottonseed oil suppress Bcl-2 and Bcl-xL expression in breast cancer cells. Pharmaceutical Research. 28: 3256-64. PMID 21710341 DOI: 10.1007/s11095-011-0498-2  0.76
2011 Bai LY, Ma Y, Kulp SK, Wang SH, Chiu CF, Frissora F, Mani R, Mo X, Jarjoura D, Byrd JC, Chen CS, Muthusamy N. OSU-DY7, a novel D-tyrosinol derivative, mediates cytotoxicity in chronic lymphocytic leukaemia and Burkitt lymphoma through p38 mitogen-activated protein kinase pathway. British Journal of Haematology. 153: 623-33. PMID 21470196 DOI: 10.1111/j.1365-2141.2010.08443.x  0.4
2011 Omar HA, Chou CC, Berman-Booty LD, Ma Y, Hung JH, Wang D, Kogure T, Patel T, Terracciano L, Muthusamy N, Byrd JC, Kulp SK, Chen CS. Antitumor effects of OSU-2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma. Hepatology (Baltimore, Md.). 53: 1943-58. PMID 21391227 DOI: 10.1002/hep.24293  0.4
2011 Chen CH, Huang PH, Chu PC, Chen MC, Chou CC, Wang D, Kulp SK, Teng CM, Wang Q, Chen CS. Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression. The Journal of Biological Chemistry. 286: 9968-76. PMID 21282102 DOI: 10.1074/jbc.M110.203240  0.4
2011 Chen MC, Chen CH, Chuang HC, Kulp SK, Teng CM, Chen CS. Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase IIα degradation in hepatocellular carcinoma cells. Hepatology (Baltimore, Md.). 53: 148-59. PMID 21254166 DOI: 10.1002/hep.23964  0.4
2011 Huang PH, Chen CH, Chou CC, Sargeant AM, Kulp SK, Teng CM, Byrd JC, Chen CS. Histone deacetylase inhibitors stimulate histone H3 lysine 4 methylation in part via transcriptional repression of histone H3 lysine 4 demethylases. Molecular Pharmacology. 79: 197-206. PMID 20959362 DOI: 10.1124/mol.110.067702  0.4
2010 Chandler HL, Webb TR, Barden CA, Thangavelu M, Kulp SK, Chen CS, Colitz CM. The effect of phosphorylated Akt inhibition on posterior capsule opacification in an ex vivo canine model. Molecular Vision. 16: 2202-14. PMID 21139685  0.4
2010 McMahon MB, Bear MD, Kulp SK, Pennell ML, London CA. Biological activity of gemcitabine against canine osteosarcoma cell lines in vitro. American Journal of Veterinary Research. 71: 799-808. PMID 20594083 DOI: 10.2460/ajvr.71.7.799  0.4
2009 Wei S, Chuang HC, Tsai WC, Yang HC, Ho SR, Paterson AJ, Kulp SK, Chen CS. Thiazolidinediones mimic glucose starvation in facilitating Sp1 degradation through the up-regulation of beta-transducin repeat-containing protein. Molecular Pharmacology. 76: 47-57. PMID 19372209 DOI: 10.1124/mol.109.055376  0.4
2008 Weng SC, Kashida Y, Kulp SK, Wang D, Brueggemeier RW, Shapiro CL, Chen CS. Sensitizing estrogen receptor-negative breast cancer cells to tamoxifen with OSU-03012, a novel celecoxib-derived phosphoinositide-dependent protein kinase-1/Akt signaling inhibitor. Molecular Cancer Therapeutics. 7: 800-8. PMID 18413793 DOI: 10.1158/1535-7163.MCT-07-0434  0.4
2008 Wang YC, Kulp SK, Wang D, Yang CC, Sargeant AM, Hung JH, Kashida Y, Yamaguchi M, Chang GD, Chen CS. Targeting endoplasmic reticulum stress and Akt with OSU-03012 and gefitinib or erlotinib to overcome resistance to epidermal growth factor receptor inhibitors. Cancer Research. 68: 2820-30. PMID 18413750 DOI: 10.1158/0008-5472.CAN-07-1336  0.4
2008 Hung JH, Lu YS, Wang YC, Ma YH, Wang DS, Kulp SK, Muthusamy N, Byrd JC, Cheng AL, Chen CS. FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling. Cancer Research. 68: 1204-12. PMID 18281497 DOI: 10.1158/0008-5472.CAN-07-2621  0.4
2007 Porchia LM, Guerra M, Wang YC, Zhang Y, Espinosa AV, Shinohara M, Kulp SK, Kirschner LS, Saji M, Chen CS, Ringel MD. 2-amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} acetamide (OSU-03012), a celecoxib derivative, directly targets p21-activated kinase. Molecular Pharmacology. 72: 1124-31. PMID 17673571 DOI: 10.1124/mol.107.037556  0.4
2007 Lu YS, Kashida Y, Kulp SK, Wang YC, Wang D, Hung JH, Tang M, Lin ZZ, Chen TJ, Cheng AL, Chen CS. Efficacy of a novel histone deacetylase inhibitor in murine models of hepatocellular carcinoma. Hepatology (Baltimore, Md.). 46: 1119-30. PMID 17654699 DOI: 10.1002/hep.21804  0.4
2007 Sargeant AM, Klein RD, Rengel RC, Clinton SK, Kulp SK, Kashida Y, Yamaguchi M, Wang X, Chen CS. Chemopreventive and bioenergetic signaling effects of PDK1/Akt pathway inhibition in a transgenic mouse model of prostate cancer. Toxicologic Pathology. 35: 549-61. PMID 17562488 DOI: 10.1080/01926230701338966  0.4
2005 Huang JW, Shiau CW, Yang YT, Kulp SK, Chen KF, Brueggemeier RW, Shapiro CL, Chen CS. Peroxisome proliferator-activated receptor gamma-independent ablation of cyclin D1 by thiazolidinediones and their derivatives in breast cancer cells. Molecular Pharmacology. 67: 1342-8. PMID 15653552 DOI: 10.1124/mol.104.007732  0.4
2004 Jiang J, Sugimoto Y, Liu S, Chang HL, Park KY, Kulp SK, Lin YC. The inhibitory effects of gossypol on human prostate cancer cells-PC3 are associated with transforming growth factor beta1 (TGFbeta1) signal transduction pathway. Anticancer Research. 24: 91-100. PMID 15015581  0.76
2002 Liu S, Sugimoto Y, Kulp SK, Jiang J, Chang HL, Park KY, Kashida Y, Lin YC. Estrogenic down-regulation of protein tyrosine phosphatase gamma (PTP gamma) in human breast is associated with estrogen receptor alpha. Anticancer Research. 22: 3917-23. PMID 12553013  0.76
2002 Jiang J, Ghosh PK, Kulp SK, Sugimoto Y, Liu S, Czekajewski J, Chang HL, Lin YC. Effects of gossypol on O2 consumption and CO2 production in human prostate cancer cells. Anticancer Research. 22: 1491-6. PMID 12168828  0.76
2002 Liu S, Kulp SK, Sugimoto Y, Jiang J, Chang HL, Dowd MK, Wan P, Lin YC. The (-)-enantiomer of gossypol possesses higher anticancer potency than racemic gossypol in human breast cancer. Anticancer Research. 22: 33-8. PMID 12017312  0.76
2002 Liu S, Kulp SK, Sugimoto Y, Jiang J, Chang HL, Lin YC. Involvement of breast epithelial-stromal interactions in the regulation of protein tyrosine phosphatase-gamma (PTPgamma) mRNA expression by estrogenically active agents. Breast Cancer Research and Treatment. 71: 21-35. PMID 11859871  0.76
2000 Jiang J, Kulp SK, Sugimoto Y, Liu S, Lin YC. The effects of gossypol on the invasiveness of MAT-LyLu cells and MAT-LyLu cells from the metastasized lungs of MAT-LyLu-bearing Copenhagen rats. Anticancer Research. 20: 4591-7. PMID 11205308  0.76
2000 Zheng J, Kulp SK, Zhang Y, Sugimoto Y, Dayton MA, Govindan MV, Brueggemeier RW, Lin YC. 17 beta-estradiol-regulated expression of protein tyrosine phosphatase gamma gene in cultured human normal breast and breast cancer cells. Anticancer Research. 20: 11-9. PMID 10769629  0.4
1998 Zhang Y, Kulp SK, Sugimoto Y, Brueggemeier RW, Lin YC. The (-)-enantiomer of gossypol inhibits proliferation of stromal cells derived from human breast adipose tissues by enhancing transforming growth factor beta1 production. International Journal of Oncology. 13: 1291-7. PMID 9824647  0.4
1998 Zhang Y, Kulp SK, Sugimoto Y, Farrar WB, Brueggemeier RW, Lin YC. Keratinocyte growth factor (KGF) induces aromatase activity in cultured MCF-7 human breast cancer cells. Anticancer Research. 18: 2541-6. PMID 9703907  0.4
1998 Zhang Y, Sugimoto Y, Kulp SK, Farrar WB, Brueggemeier RW, Lin YC. Estrogen-induced keratinocyte growth factor mRNA expression in normal and cancerous human breast cells. Oncology Reports. 5: 577-83. PMID 9538155  0.4
1997 Canatan H, Shidaifat F, Kulp SK, Zhang Y, Chang WY, Brueggemeir RW, Lin YC. Differential effect of keratinocyte growth factor (KGF) on aromatase activity in cultured canine prostatic epithelial cells. Endocrine Research. 23: 311-23. PMID 9430821  0.4
1997 Shidaifat F, Canatan H, Kulp SK, Sugimoto Y, Zhang Y, Brueggemeier RW, Somers WJ, Chang WY, Wang HC, Lin YC. Gossypol arrests human benign prostatic hyperplastic cell growth at G0/G1 phase of the cell cycle. Anticancer Research. 17: 1003-9. PMID 9137441  0.4
1997 Chang WY, Sugimoto Y, Shidaifat F, Kulp SK, Canatan H, Lin YC. Gossypol induces spermidine/spermine N1-acetyltransferase in canine prostate epithelial cells. Biochemical and Biophysical Research Communications. 231: 383-8. PMID 9070284 DOI: 10.1006/bbrc.1997.6108  0.76
1996 Chang WY, Kulp SK, Sugimoto Y, Canatan H, Shidaifat F, Inpanbutr N, Lin YC. Detection of keratinocyte growth factor (KGF) messenger ribonucleic acid and immunolocalization of KGF in the canine testis. Endocrine. 5: 247-55. PMID 21153075 DOI: 10.1007/BF02739057  0.76
1996 Shidaifat F, Canatan H, Kulp SK, Sugimoto Y, Chang WY, Zhang Y, Brueggemeier RW, Somers WJ, Lin YC. Inhibition of human prostate cancer cells growth by gossypol is associated with stimulation of transforming growth factor-beta. Cancer Letters. 107: 37-44. PMID 8913264 DOI: 10.1016/0304-3835(96)04340-6  0.4
1996 Chang WY, Shidaifat F, Chang CJ, Kulp SK, Sugimoto Y, Canatan H, Brueggemeier RW, Lin YC. Experimentally-induced prostatic hyperplasia in young beagles: a model to evaluate the chemotherapeutic effects of gossypol. Research Communications in Molecular Pathology and Pharmacology. 92: 341-60. PMID 8827831  0.4
1996 Canatan H, Chang WY, Sugimoto Y, Shidaifat F, Kulp SK, Brueggemeier RW, Lin YC. Keratinocyte growth factor (KGF/FGF-7) has a paracrine role in canine prostate: molecular cloning of mRNA encoding canine KGF. Dna and Cell Biology. 15: 247-54. PMID 8634153 DOI: 10.1089/dna.1996.15.247  0.76
1993 Chang WY, Ohmura H, Kulp SK, Lin YC. Transforming growth factor-beta(1) regulates differentiation of porcine granulosa cells in vitro. Theriogenology. 40: 699-712. PMID 16727352  0.76
1993 Kulp SK, Rikihisa Y, Lin YC, Moh PP, Li PK, Gu Y. In vitro uptake and autoradiographic localization of tritiated gossypol in Taenia taeniaeformis metacestodes. Parasitology Research. 79: 279-85. PMID 8327450  0.76
1992 Lin YC, Hu YF, Chang CJ, Moh PP, Kulp SK. Transfer of 3H-gossypol to neonatal rats via milk of nursing dams. Life Sciences. 51: 1657-65. PMID 1435075  0.76
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