Tadhg P. Begley, Ph.D. - Publications

Affiliations: 
Chemistry Texas A & M University, College Station, TX, United States 
Area:
Barton Professor of Chemistry
Website:
http://www.chem.tamu.edu/rgroup/begley/Principal%20Investigator.htm

217 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Sayler RI, Stich TA, Joshi S, Cooper N, Shaw JT, Begley TP, Tantillo DJ, Britt RD. Trapping and Electron Paramagnetic Resonance Characterization of the 5'dAdo Radical in a Radical -Adenosyl Methionine Enzyme Reaction with a Non-Native Substrate. Acs Central Science. 5: 1777-1785. PMID 31807679 DOI: 10.1021/acscentsci.9b00706  0.44
2019 Joshi S, Fedoseyenko D, Mahanta N, Ducati RG, Feng M, Schramm VL, Begley TP. Antibacterial Strategy against : Inhibition of the Radical SAM Enzyme MqnE in Menaquinone Biosynthesis. Acs Medicinal Chemistry Letters. 10: 363-366. PMID 30891141 DOI: 10.1021/acsmedchemlett.8b00649  0.4
2019 Mahanta N, Hicks KA, Naseem S, Fedoseyenko D, Ealick SE, Begley TP. Menaquinone Biosynthesis: Biochemical and Structural Studies on chorismate dehydratase. Biochemistry. PMID 30855131 DOI: 10.1021/acs.biochem.9b00105  0.6
2018 Joshi S, Fedoseyenko D, Mahanta N, Manion H, Naseem S, Dairi T, Begley TP. Novel enzymology in futalosine-dependent menaquinone biosynthesis. Current Opinion in Chemical Biology. 47: 134-141. PMID 30447488 DOI: 10.1016/j.cbpa.2018.09.015  0.4
2018 Gagnon DM, Stich TA, Mehta AP, Abdelwahed SH, Begley TP, Britt RD. An Aminoimidazole Radical Intermediate in the Anaerobic Biosynthesis of the 5,6-dimethylbenzimidazole Ligand to Vitamin B12. Journal of the American Chemical Society. PMID 30208703 DOI: 10.1021/jacs.8b05686  0.8
2018 Joshi S, Fedoseyenko D, Mahanta N, Begley TP. Aminofutalosine Synthase (MqnE): A New Catalytic Motif in Radical SAM Enzymology. Methods in Enzymology. 606: 179-198. PMID 30097092 DOI: 10.1016/bs.mie.2018.05.002  0.4
2018 Bhandari DM, Fedoseyenko D, Begley TP. Mechanistic Studies on the Radical SAM Enzyme Tryptophan Lyase (NosL). Methods in Enzymology. 606: 155-178. PMID 30097091 DOI: 10.1016/bs.mie.2018.06.008  0.4
2017 Bhandari DM, Fedoseyenko D, Begley TP. Mechanistic Studies on Tryptophan Lyase (NosL): Identification of Cyanide as a Reaction Product. Journal of the American Chemical Society. PMID 29232124 DOI: 10.1021/jacs.7b09000  0.4
2017 Gutowska MA, Shome B, Sudek S, McRose DL, Hamilton M, Giovannoni SJ, Begley TP, Worden AZ. Globally Important Haptophyte Algae Use Exogenous Pyrimidine Compounds More Efficiently than Thiamin. Mbio. 8. PMID 29018119 DOI: 10.1128/mBio.01459-17  0.32
2017 Joshi S, Mahanta N, Fedoseyenko D, Williams HJ, Begley TP. Aminofutalosine Synthase: evidence for captodative and aryl radical intermediates using beta scission and SRN1 trapping reactions. Journal of the American Chemical Society. PMID 28701039 DOI: 10.1021/jacs.7b04209  0.4
2017 Fenwick MK, Almabruk KH, Ealick SE, Begley TP, Philmus B. Biochemical characterization and structural basis of reactivity and regioselectivity differences of Burkholderia thailandensis and Burkholderia glumae 1,6-didesmethyltoxoflavin N-methyltransferase. Biochemistry. PMID 28665591 DOI: 10.1021/acs.biochem.7b00476  0.6
2017 Rodrigues MJ, Windeisen V, Zhang Y, Guédez G, Weber S, Strohmeier M, Hanes JW, Royant A, Evans G, Sinning I, Ealick SE, Begley TP, Tews I. Lysine relay mechanism coordinates intermediate transfer in vitamin B6 biosynthesis. Nature Chemical Biology. PMID 28092359 DOI: 10.1038/nchembio.2273  0.64
2016 Bhandari DM, Fedoseyenko D, Begley TP. Tryptophan Lyase (NosL): A Cornucopia of 5'-Deoxyadenosyl Radical Mediated Transformations. Journal of the American Chemical Society. 138: 16184-16187. PMID 27998091 DOI: 10.1021/jacs.6b06139  0.4
2016 Xu H, Chakrabarty Y, Philmus B, Mehta AP, Bhandari D, Hohmann HP, Begley TP. IIdentification of the first Riboflavin Catabolic Gene Cluster isolated from Microbacterium maritypicum G10. The Journal of Biological Chemistry. PMID 27590337 DOI: 10.1074/jbc.M116.729871  0.8
2016 Jhulki I, Chanani PK, Abdelwahed S, Begley TP. A remarkable oxidative cascade that replaces the riboflavin C8 methyl with an amino group during roseoflavin biosynthesis. Journal of the American Chemical Society. PMID 27331868 DOI: 10.1021/jacs.6b02469  1
2016 Adak S, Begley TP. Dibenzothiophene Catabolism proceeds via a Flavin-N5-oxide Intermediate. Journal of the American Chemical Society. PMID 27120486 DOI: 10.1021/jacs.6b00583  1
2016 Fenwick MK, Philmus B, Begley TP, Ealick SE. Burkholderia glumae ToxA is a Dual Specificity Methyltransferase that Catalyzes the Last Two Steps of Toxoflavin Biosynthesis. Biochemistry. PMID 27070241 DOI: 10.1021/acs.biochem.6b00167  1
2016 Eser BE, Zhang X, Chanani PK, Begley TP, Ealick SE. From suicide enzyme to catalyst: the iron-dependent sulfide transfer in Methanococcus jannaschii thiamin thiazole biosynthesis. Journal of the American Chemical Society. PMID 26928142 DOI: 10.1021/jacs.6b00445  0.6
2016 Zhang X, Eser BE, Chanani PK, Begley TP, Ealick SE. Structural Basis for Iron-mediated Sulfur Transfer in Archael and Yeast Thiazole Synthases. Biochemistry. PMID 26919468 DOI: 10.1021/acs.biochem.6b00030  0.6
2016 Nemeria NS, Shome B, DeColli AA, Heflin K, Begley TP, Meyers CF, Jordan F. COMPETENCE OF THIAMIN DIPHOSPHATE-DEPENDENT ENZYMES WITH 2'-METHOXYTHIAMIN DIPHOSPHATE DERIVED FROM BACIMETHRIN, A NATURALLY OCCURRING THIAMIN ANTI-VITAMIN. Biochemistry. PMID 26813608 DOI: 10.1021/acs.biochem.5b01300  1
2015 Hazra AB, Han AW, Mehta AP, Mok KC, Osadchiy V, Begley TP, Taga ME. Anaerobic biosynthesis of the lower ligand of vitamin B12. Proceedings of the National Academy of Sciences of the United States of America. 112: 10792-7. PMID 26246619 DOI: 10.1073/pnas.1509132112  1
2015 Mehta AP, Abdelwahed SH, Fenwick MK, Hazra AB, Taga ME, Zhang Y, Ealick SE, Begley TP. Anaerobic 5-Hydroxybenzimidazole formation from aminoimidazole ribotide: an unanticipated intersection of thiamin and vitamin B12 biosynthesis. Journal of the American Chemical Society. PMID 26237670 DOI: 10.1021/jacs.5b03576  1
2015 Bhandari DM, Xu H, Nicolet Y, Fontecilla-Camps JC, Begley TP. Tryptophan lyase (NosL): mechanistic insights from substrate analogs and mutagenesis. Biochemistry. PMID 26204056 DOI: 10.1021/acs.biochem.5b00764  1
2015 Philmus B, Shaffer BT, Kidarsa TA, Yan Q, Raaijmakers JM, Begley TP, Loper JE. Investigations into the Biosynthesis, Regulation, and Self-Resistance of Toxoflavin in Pseudomonas protegens Pf-5. Chembiochem : a European Journal of Chemical Biology. PMID 26077901 DOI: 10.1002/cbic.201500247  1
2015 Mehta AP, Abdelwahed SH, Begley TP. Molybdopterin biosynthesis-Mechanistic studies on a novel MoaA catalyzed insertion of a purine carbon into the ribose of GTP. Biochimica Et Biophysica Acta. PMID 25896388 DOI: 10.1016/j.bbapap.2015.04.008  1
2015 Fenwick MK, Mehta AP, Zhang Y, Abdelwahed SH, Begley TP, Ealick SE. Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase. Nature Communications. 6: 6480. PMID 25813242 DOI: 10.1038/ncomms7480  1
2015 Philmus B, Decamps L, Berteau O, Begley TP. Biosynthetic versatility and coordinated action of 5'-deoxyadenosyl radicals in deazaflavin biosynthesis. Journal of the American Chemical Society. 137: 5406-13. PMID 25781338 DOI: 10.1021/ja513287k  1
2015 Mehta AP, Abdelwahed SH, Mahanta N, Fedoseyenko D, Philmus B, Cooper LE, Liu Y, Jhulki I, Ealick SE, Begley TP. Radical S-adenosylmethionine (SAM) enzymes in cofactor biosynthesis: a treasure trove of complex organic radical rearrangement reactions. The Journal of Biological Chemistry. 290: 3980-6. PMID 25477515 DOI: 10.1074/jbc.R114.623793  1
2014 McRose D, Guo J, Monier A, Sudek S, Wilken S, Yan S, Mock T, Archibald JM, Begley TP, Reyes-Prieto A, Worden AZ. Alternatives to vitamin B1 uptake revealed with discovery of riboswitches in multiple marine eukaryotic lineages. The Isme Journal. 8: 2517-29. PMID 25171333 DOI: 10.1038/ismej.2014.146  1
2014 Mehta AP, Abdelwahed SH, Xu H, Begley TP. Molybdopterin biosynthesis: trapping of intermediates for the MoaA-catalyzed reaction using 2'-deoxyGTP and 2'-chloroGTP as substrate analogues. Journal of the American Chemical Society. 136: 10609-14. PMID 24955657 DOI: 10.1021/ja502663k  1
2014 Carini P, Campbell EO, Morré J, Sañudo-Wilhelmy SA, Thrash JC, Bennett SE, Temperton B, Begley T, Giovannoni SJ. Discovery of a SAR11 growth requirement for thiamin's pyrimidine precursor and its distribution in the Sargasso Sea. The Isme Journal. 8: 1727-38. PMID 24781899 DOI: 10.1038/ismej.2014.61  1
2014 Cooper LE, O'Leary SE, Begley TP. Biosynthesis of a thiamin antivitamin in Clostridium botulinum. Biochemistry. 53: 2215-7. PMID 24654570 DOI: 10.1021/bi500281a  1
2013 Coquille S, Roux C, Mehta A, Begley TP, Fitzpatrick TB, Thore S. High-resolution crystal structure of the eukaryotic HMP-P synthase (THIC) from Arabidopsis thaliana. Journal of Structural Biology. 184: 438-44. PMID 24161603 DOI: 10.1016/j.jsb.2013.10.005  1
2013 Mahanta N, Fedoseyenko D, Dairi T, Begley TP. Menaquinone biosynthesis: formation of aminofutalosine requires a unique radical SAM enzyme. Journal of the American Chemical Society. 135: 15318-21. PMID 24083939 DOI: 10.1021/ja408594p  1
2013 Sikowitz MD, Shome B, Zhang Y, Begley TP, Ealick SE. Structure of a Clostridium botulinum C143S thiaminase I/thiamin complex reveals active site architecture . Biochemistry. 52: 7830-9. PMID 24079939 DOI: 10.1021/bi400841g  1
2013 Soriano EV, Zhang Y, Colabroy KL, Sanders JM, Settembre EC, Dorrestein PC, Begley TP, Ealick SE. Active-site models for complexes of quinolinate synthase with substrates and intermediates. Acta Crystallographica. Section D, Biological Crystallography. 69: 1685-96. PMID 23999292 DOI: 10.1107/S090744491301247X  1
2013 Liu Hw, Begley T. Natural product biosynthesis-a Renaissance Current Opinion in Chemical Biology. 17: 529-531. PMID 23891474 DOI: 10.1016/j.cbpa.2013.07.005  1
2013 Mehta AP, Abdelwahed SH, Begley TP. Molybdopterin biosynthesis: trapping an unusual purine ribose adduct in the MoaA-catalyzed reaction. Journal of the American Chemical Society. 135: 10883-5. PMID 23848839 DOI: 10.1021/ja4041048  1
2013 Cooper LE, Fedoseyenko D, Abdelwahed SH, Kim SH, Dairi T, Begley TP. In vitro reconstitution of the radical S-adenosylmethionine enzyme MqnC involved in the biosynthesis of futalosine-derived menaquinone. Biochemistry. 52: 4592-4. PMID 23763543 DOI: 10.1021/bi400498d  1
2013 Sikowitz MD, Cooper LE, Begley TP, Kaminski PA, Ealick SE. Reversal of the substrate specificity of CMP N-glycosidase to dCMP. Biochemistry. 52: 4037-47. PMID 23659472 DOI: 10.1021/bi400316p  1
2013 Gokulan K, O'Leary SE, Russell WK, Russell DH, Lalgondar M, Begley TP, Ioerger TR, Sacchettini JC. Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones. The Journal of Biological Chemistry. 288: 16484-94. PMID 23615910 DOI: 10.1074/jbc.M113.468892  1
2013 Mehta AP, Hanes JW, Abdelwahed SH, Hilmey DG, Hänzelmann P, Begley TP. Catalysis of a new ribose carbon-insertion reaction by the molybdenum cofactor biosynthetic enzyme MoaA. Biochemistry. 52: 1134-6. PMID 23286307 DOI: 10.1021/bi3016026  1
2013 Hicks KA, O'Leary SE, Begley TP, Ealick SE. Structural and mechanistic studies of HpxO, a novel flavin adenine dinucleotide-dependent urate oxidase from Klebsiella pneumoniae. Biochemistry. 52: 477-87. PMID 23259842 DOI: 10.1021/bi301262p  1
2013 Burns KE, Begley TP. Mec+ Peptidase (Mycobacterium tuberculosis) Handbook of Proteolytic Enzymes. 2: 1567-1570. DOI: 10.1016/B978-0-12-382219-2.00353-7  1
2012 Decamps L, Philmus B, Benjdia A, White R, Begley TP, Berteau O. Biosynthesis of F0, precursor of the F420 cofactor, requires a unique two radical-SAM domain enzyme and tyrosine as substrate. Journal of the American Chemical Society. 134: 18173-6. PMID 23072415 DOI: 10.1021/ja307762b  1
2012 Huang S, Mahanta N, Begley TP, Ealick SE. Pseudouridine monophosphate glycosidase: a new glycosidase mechanism. Biochemistry. 51: 9245-55. PMID 23066817 DOI: 10.1021/bi3006829  1
2012 Coats D, Shelton-Dodge K, Ou K, Khun V, Seab S, Sok K, Prou C, Tortorelli S, Moyer TP, Cooper LE, Begley TP, Enders F, Fischer PR, Topazian M. Thiamine deficiency in Cambodian infants with and without beriberi. The Journal of Pediatrics. 161: 843-7. PMID 22703952 DOI: 10.1016/j.jpeds.2012.05.006  1
2012 Begley TP, Ealick SE, McLafferty FW. Thiamin biosynthesis: still yielding fascinating biological chemistry. Biochemical Society Transactions. 40: 555-60. PMID 22616866 DOI: 10.1042/BST20120084  1
2012 Lai RY, Huang S, Fenwick MK, Hazra A, Zhang Y, Rajashankar K, Philmus B, Kinsland C, Sanders JM, Ealick SE, Begley TP. Thiamin pyrimidine biosynthesis in Candida albicans : a remarkable reaction between histidine and pyridoxal phosphate. Journal of the American Chemical Society. 134: 9157-9. PMID 22568620 DOI: 10.1021/ja302474a  1
2012 Greenwald JW, Greenwald CJ, Philmus BJ, Begley TP, Gross DC. RNA-seq analysis reveals that an ECF σ factor, AcsS, regulates achromobactin biosynthesis in Pseudomonas syringae pv. syringae B728a. Plos One. 7: e34804. PMID 22529937 DOI: 10.1371/journal.pone.0034804  1
2012 Philmus B, Abdelwahed S, Williams HJ, Fenwick MK, Ealick SE, Begley TP. Identification of the product of toxoflavin lyase: degradation via a Baeyer-Villiger oxidation. Journal of the American Chemical Society. 134: 5326-30. PMID 22304755 DOI: 10.1021/ja211759n  1
2011 Chatterjee A, Abeydeera ND, Bale S, Pai PJ, Dorrestein PC, Russell DH, Ealick SE, Begley TP. Saccharomyces cerevisiae THI4p is a suicide thiamine thiazole synthase. Nature. 478: 542-6. PMID 22031445 DOI: 10.1038/nature10503  1
2011 Tran TH, Krishnamoorthy K, Begley TP, Ealick SE. A novel mechanism of sulfur transfer catalyzed by O-acetylhomoserine sulfhydrylase in the methionine-biosynthetic pathway of Wolinella succinogenes. Acta Crystallographica. Section D, Biological Crystallography. 67: 831-8. PMID 21931214 DOI: 10.1107/S0907444911028010  1
2011 French JB, Begley TP, Ealick SE. Structure of trifunctional THI20 from yeast. Acta Crystallographica. Section D, Biological Crystallography. 67: 784-91. PMID 21904031 DOI: 10.1107/S0907444911024814  1
2011 Mukherjee T, Hanes J, Tews I, Ealick SE, Begley TP. Pyridoxal phosphate: biosynthesis and catabolism. Biochimica Et Biophysica Acta. 1814: 1585-96. PMID 21767669 DOI: 10.1016/j.bbapap.2011.06.018  1
2011 Pribat A, Blaby IK, Lara-Núñez A, Jeanguenin L, Fouquet R, Frelin O, Gregory JF, Philmus B, Begley TP, de Crécy-Lagard V, Hanson AD. A 5-formyltetrahydrofolate cycloligase paralog from all domains of life: comparative genomic and experimental evidence for a cryptic role in thiamin metabolism. Functional & Integrative Genomics. 11: 467-78. PMID 21538139 DOI: 10.1007/s10142-011-0224-5  1
2011 Hazra AB, Han Y, Chatterjee A, Zhang Y, Lai RY, Ealick SE, Begley TP. A missing enzyme in thiamin thiazole biosynthesis: identification of TenI as a thiazole tautomerase. Journal of the American Chemical Society. 133: 9311-9. PMID 21534620 DOI: 10.1021/ja1110514  1
2011 Paramasivam S, Balakrishnan A, Dmitrenko O, Godert A, Begley TP, Jordan F, Polenova T. Solid-state NMR and density functional theory studies of ionization states of thiamin. The Journal of Physical Chemistry. B. 115: 730-6. PMID 21175136 DOI: 10.1021/jp109765b  1
2011 Fenwick MK, Philmus B, Begley TP, Ealick SE. Toxoflavin lyase requires a novel 1-His-2-carboxylate facial triad. Biochemistry. 50: 1091-100. PMID 21166463 DOI: 10.1021/bi101741v  1
2011 Krishnamoorthy K, Begley TP. Protein thiocarboxylate-dependent methionine biosynthesis in Wolinella succinogenes. Journal of the American Chemical Society. 133: 379-86. PMID 21162571 DOI: 10.1021/ja107424t  1
2011 Hanes JW, Chatterjee D, Soriano EV, Ealick SE, Begley TP. Construction of a thiamin sensor from the periplasmic thiamin binding protein. Chemical Communications (Cambridge, England). 47: 2273-5. PMID 21125117 DOI: 10.1039/c0cc04228e  1
2011 Lin H, Begley T. Protein posttranslational modifications: chemistry, biology, and applications. Molecular Biosystems. 7: 14-5. PMID 21107473 DOI: 10.1039/c0mb90037k  1
2010 Honeyfield DC, Hanes JW, Brown L, Kraft CE, Begley TP. Comparison of thiaminase activity in fish using the radiometric and 4-nitrothiophenol colorimetric methods. Journal of Great Lakes Research. 36: 641-645. PMID 30008512 DOI: 10.1016/j.jglr.2010.07.005  0.64
2010 Woodward JB, Abeydeera ND, Paul D, Phillips K, Rapala-Kozik M, Freeling M, Begley TP, Ealick SE, McSteen P, Scanlon MJ. A maize thiamine auxotroph is defective in shoot meristem maintenance. The Plant Cell. 22: 3305-17. PMID 20971897 DOI: 10.1105/tpc.110.077776  0.6
2010 Paul D, Chatterjee A, Begley TP, Ealick SE. Domain organization in Candida glabrata THI6, a bifunctional enzyme required for thiamin biosynthesis in eukaryotes. Biochemistry. 49: 9922-34. PMID 20968298 DOI: 10.1021/bi101008u  1
2010 Chatterjee A, Hazra AB, Abdelwahed S, Hilmey DG, Begley TP. A "radical dance" in thiamin biosynthesis: mechanistic analysis of the bacterial hydroxymethylpyrimidine phosphate synthase. Angewandte Chemie (International Ed. in English). 49: 8653-6. PMID 20886485 DOI: 10.1002/anie.201003419  1
2010 Bale S, Rajashankar KR, Perry K, Begley TP, Ealick SE. HMP binding protein ThiY and HMP-P synthase THI5 are structural homologues. Biochemistry. 49: 8929-36. PMID 20873853 DOI: 10.1021/bi101209t  1
2010 Krishnamoorthy K, Begley TP. Reagent for the detection of protein thiocarboxylates in the bacterial proteome: lissamine rhodamine B sulfonyl azide. Journal of the American Chemical Society. 132: 11608-12. PMID 20677756 DOI: 10.1021/ja1034107  1
2010 Mukherjee T, Zhang Y, Abdelwahed S, Ealick SE, Begley TP. Catalysis of a flavoenzyme-mediated amide hydrolysis. Journal of the American Chemical Society. 132: 5550-1. PMID 20369853 DOI: 10.1021/ja9107676  1
2010 Paul D, O'Leary SE, Rajashankar K, Bu W, Toms A, Settembre EC, Sanders JM, Begley TP, Ealick SE. Glycal formation in crystals of uridine phosphorylase. Biochemistry. 49: 3499-509. PMID 20364833 DOI: 10.1021/bi902073b  1
2010 McCulloch KM, Mukherjee T, Begley TP, Ealick SE. Structure determination and characterization of the vitamin B6 degradative enzyme (E)-2-(acetamidomethylene)succinate hydrolase. Biochemistry. 49: 1226-35. PMID 20099871 DOI: 10.1021/bi901812p  1
2010 Liu S, Monks NR, Hanes JW, Begley TP, Yu H, Moscow JA. Sensitivity of breast cancer cell lines to recombinant thiaminase I. Cancer Chemotherapy and Pharmacology. 66: 171-9. PMID 19830429 DOI: 10.1007/s00280-009-1148-9  1
2010 Honeyfield DC, Hanes JW, Brown L, Kraft CE, Begley TP. Comparison of thiaminase activity in fish using the radiometric and 4-nitrothiophenol colorimetric methods Journal of Great Lakes Research. 36: 641-645. DOI: 10.1016/j.jglr.2010.07.005  1
2010 Mukherjee T, McCulloch KM, Ealick SE, Begley TP. Cofactor catabolism Comprehensive Natural Products Ii: Chemistry and Biology. 7: 649-674.  1
2010 Hanes JW, Ealick SE, Begley TP, Tews I. Pyridoxal phosphate biosynthesis Comprehensive Natural Products Ii: Chemistry and Biology. 7: 259-272.  1
2010 Begley TP. Overview and introduction Comprehensive Natural Products Ii: Chemistry and Biology. 7: 1-2.  1
2009 Jurgenson CT, Ealick SE, Begley TP. Biosynthesis of Thiamin Pyrophosphate. Ecosal Plus. 3. PMID 26443755 DOI: 10.1128/ecosalplus.3.6.3.7  1
2009 Müller IB, Bergmann B, Groves MR, Couto I, Amaral L, Begley TP, Walter RD, Wrenger C. The vitamin B1 metabolism of Staphylococcus aureus is controlled at enzymatic and transcriptional levels. Plos One. 4: e7656. PMID 19888457 DOI: 10.1371/journal.pone.0007656  1
2009 Jurgenson CT, Begley TP, Ealick SE. The structural and biochemical foundations of thiamin biosynthesis. Annual Review of Biochemistry. 78: 569-603. PMID 19348578 DOI: 10.1146/annurev.biochem.78.072407.102340  1
2009 McCulloch KM, Mukherjee T, Begley TP, Ealick SE. Structure of the PLP degradative enzyme 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase from Mesorhizobium loti MAFF303099 and its mechanistic implications. Biochemistry. 48: 4139-49. PMID 19317437 DOI: 10.1021/bi900149f  1
2009 O'Leary SE, Hicks KA, Ealick SE, Begley TP. Biochemical characterization of the HpxO enzyme from Klebsiella pneumoniae, a novel FAD-dependent urate oxidase. Biochemistry. 48: 3033-5. PMID 19260710 DOI: 10.1021/bi900160b  1
2009 Hazra A, Chatterjee A, Begley TP. Biosynthesis of the thiamin thiazole in Bacillus subtilis: identification of the product of the thiazole synthase-catalyzed reaction. Journal of the American Chemical Society. 131: 3225-9. PMID 19216519 DOI: 10.1021/ja806752h  1
2008 Chatterjee A, Li Y, Zhang Y, Grove TL, Lee M, Krebs C, Booker SJ, Begley TP, Ealick SE. Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily. Nature Chemical Biology. 4: 758-65. PMID 18953358 DOI: 10.1038/nchembio.121  1
2008 Simmons CR, Krishnamoorthy K, Granett SL, Schuller DJ, Dominy JE, Begley TP, Stipanuk MH, Karplus PA. A putative Fe2+-bound persulfenate intermediate in cysteine dioxygenase. Biochemistry. 47: 11390-2. PMID 18847220 DOI: 10.1021/bi801546n  1
2008 O'Leary SE, Jurgenson CT, Ealick SE, Begley TP. O-phospho-L-serine and the thiocarboxylated sulfur carrier protein CysO-COSH are substrates for CysM, a cysteine synthase from Mycobacterium tuberculosis. Biochemistry. 47: 11606-15. PMID 18842002 DOI: 10.1021/bi8013664  1
2008 Jurgenson CT, Burns KE, Begley TP, Ealick SE. Crystal structure of a sulfur carrier protein complex found in the cysteine biosynthetic pathway of Mycobacterium tuberculosis. Biochemistry. 47: 10354-64. PMID 18771296 DOI: 10.1021/bi800915j  1
2008 Chatterjee A, Schroeder FC, Jurgenson CT, Ealick SE, Begley TP. Biosynthesis of the thiamin-thiazole in eukaryotes: identification of a thiazole tautomer intermediate. Journal of the American Chemical Society. 130: 11394-8. PMID 18652458 DOI: 10.1021/ja802140a  1
2008 Hanes JW, Keresztes I, Begley TP. 13C NMR snapshots of the complex reaction coordinate of pyridoxal phosphate synthase. Nature Chemical Biology. 4: 425-30. PMID 18516049 DOI: 10.1038/nchembio.93  1
2008 Mukherjee T, Hilmey DG, Begley TP. PLP catabolism: identification of the 2-(Acetamidomethylene)succinate hydrolase gene in Mesorhizobium loti MAFF303099. Biochemistry. 47: 6233-41. PMID 18476725 DOI: 10.1021/bi8004158  1
2008 Begley TP, Chatterjee A, Hanes JW, Hazra A, Ealick SE. Cofactor biosynthesis--still yielding fascinating new biological chemistry. Current Opinion in Chemical Biology. 12: 118-25. PMID 18314013 DOI: 10.1016/j.cbpa.2008.02.006  1
2008 McCulloch KM, Kinsland C, Begley TP, Ealick SE. Structural studies of thiamin monophosphate kinase in complex with substrates and products. Biochemistry. 47: 3810-21. PMID 18311927 DOI: 10.1021/bi800041h  1
2008 Hanes JW, Burns KE, Hilmey DG, Chatterjee A, Dorrestein PC, Begley TP. Mechanistic studies on pyridoxal phosphate synthase: the reaction pathway leading to a chromophoric intermediate. Journal of the American Chemical Society. 130: 3043-52. PMID 18271580 DOI: 10.1021/ja076604l  1
2008 Hanes JW, Keresztes I, Begley TP. Trapping of a chromophoric intermediate in the Pdx1-catalyzed biosynthesis of pyridoxal 5'-phosphate. Angewandte Chemie (International Ed. in English). 47: 2102-5. PMID 18260082 DOI: 10.1002/anie.200704390  1
2008 Mori H, Begley T. Metabolomic analysis of microorganisms Molecular Biosystems. 4: 108-109. PMID 18213402 DOI: 10.1039/b719453f  1
2008 Soriano EV, Rajashankar KR, Hanes JW, Bale S, Begley TP, Ealick SE. Structural similarities between thiamin-binding protein and thiaminase-I suggest a common ancestor. Biochemistry. 47: 1346-57. PMID 18177053 DOI: 10.1021/bi7018282  1
2008 Jenkins AL, Zhang Y, Ealick SE, Begley TP. Mutagenesis studies on TenA: a thiamin salvage enzyme from Bacillus subtilis. Bioorganic Chemistry. 36: 29-32. PMID 18054064 DOI: 10.1016/j.bioorg.2007.10.005  1
2007 Fecko CJ, Munson KM, Saunders A, Sun G, Begley TP, Lis JT, Webb WW. Comparison of femtosecond laser and continuous wave UV sources for protein-nucleic acid crosslinking. Photochemistry and Photobiology. 83: 1394-404. PMID 18028214 DOI: 10.1111/j.1751-1097.2007.00179.x  1
2007 McLafferty FW, Breuker K, Jin M, Han X, Infusini G, Jiang H, Kong X, Begley TP. Top-down MS, a powerful complement to the high capabilities of proteolysis proteomics. The Febs Journal. 274: 6256-68. PMID 18021240 DOI: 10.1111/j.1742-4658.2007.06147.x  1
2007 Mukherjee T, McCulloch KM, Ealick SE, Begley TP. Gene identification and structural characterization of the pyridoxal 5'-phosphate degradative protein 3-hydroxy-2-methylpyridine-4,5-dicarboxylate decarboxylase from mesorhizobium loti MAFF303099. Biochemistry. 46: 13606-15. PMID 17973403 DOI: 10.1021/bi701439j  1
2007 Mukherjee T, Kinsland C, Begley TP. PLP catabolism: identification of the 4-pyridoxic acid dehydrogenase gene in Mesorhizobium loti MAFF303099. Bioorganic Chemistry. 35: 458-64. PMID 17868768 DOI: 10.1016/j.bioorg.2007.07.003  1
2007 Jenkins AH, Schyns G, Potot S, Sun G, Begley TP. A new thiamin salvage pathway. Nature Chemical Biology. 3: 492-7. PMID 17618314 DOI: 10.1038/nchembio.2007.13  1
2007 Hanes JW, Kraft CE, Begley TP. An assay for thiaminase I in complex biological samples. Analytical Biochemistry. 368: 33-8. PMID 17603991 DOI: 10.1016/j.ab.2007.06.001  1
2007 Hanes JW, Ealick SE, Begley TP. Thiamin phosphate synthase: the rate of pyrimidine carbocation formation. Journal of the American Chemical Society. 129: 4860-1. PMID 17388590 DOI: 10.1021/ja0679634  1
2007 Ealick SE, Begley TP. Biochemistry: molecular cannibalism. Nature. 446: 387-8. PMID 17377573 DOI: 10.1038/446387a  1
2007 Chatterjee A, Jurgenson CT, Schroeder FC, Ealick SE, Begley TP. Biosynthesis of thiamin thiazole in eukaryotes: conversion of NAD to an advanced intermediate. Journal of the American Chemical Society. 129: 2914-22. PMID 17309261 DOI: 10.1021/ja067606t  1
2007 Godert AM, Jin M, McLafferty FW, Begley TP. Biosynthesis of the thioquinolobactin siderophore: an interesting variation on sulfur transfer. Journal of Bacteriology. 189: 2941-4. PMID 17209031 DOI: 10.1128/JB.01200-06  1
2007 Zhang Y, Kang SA, Mukherjee T, Bale S, Crane BR, Begley TP, Ealick SE. Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis. Biochemistry. 46: 145-55. PMID 17198384 DOI: 10.1021/bi0620095  1
2007 Osterman AL, Begley TP. A subsystems-based approach to the identification of drug targets in bacterial pathogens. Progress in Drug Research. Fortschritte Der Arzneimittelforschung. ProgrèS Des Recherches Pharmaceutiques. 64: 131, 133-70. PMID 17195474 DOI: 10.1007/978-3-7643-7567-6_6  1
2006 Zein F, Zhang Y, Kang YN, Burns K, Begley TP, Ealick SE. Structural insights into the mechanism of the PLP synthase holoenzyme from Thermotoga maritima. Biochemistry. 45: 14609-20. PMID 17144654 DOI: 10.1021/bi061464y  1
2006 Jurgenson CT, Chatterjee A, Begley TP, Ealick SE. Structural insights into the function of the thiamin biosynthetic enzyme Thi4 from Saccharomyces cerevisiae. Biochemistry. 45: 11061-70. PMID 16964967 DOI: 10.1021/bi061025z  1
2006 Mansoorabadi SO, Seravalli J, Furdui C, Krymov V, Gerfen GJ, Begley TP, Melnick J, Ragsdale SW, Reed GH. EPR spectroscopic and computational characterization of the hydroxyethylidene-thiamine pyrophosphate radical intermediate of pyruvate:ferredoxin oxidoreductase. Biochemistry. 45: 7122-31. PMID 16752902 DOI: 10.1021/bi0602516  1
2006 Chatterjee A, Jurgenson CT, Schroeder FC, Ealick SE, Begley TP. Thiamin biosynthesis in eukaryotes: characterization of the enzyme-bound product of thiazole synthase from Saccharomyces cerevisiae and its implications in thiazole biosynthesis. Journal of the American Chemical Society. 128: 7158-9. PMID 16734458 DOI: 10.1021/ja061413o  1
2006 Chatterjee A, Han X, McLafferty FW, Begley TP. Biosynthesis of thiamin thiazole: determination of the regiochemistry of the S/O acyl shift by using 1,4-dideoxy-D-xylulose-5-phosphate. Angewandte Chemie (International Ed. in English). 45: 3507-10. PMID 16625663 DOI: 10.1002/anie.200504614  1
2006 Simmons CR, Liu Q, Huang Q, Hao Q, Begley TP, Karplus PA, Stipanuk MH. Crystal structure of mammalian cysteine dioxygenase. A novel mononuclear iron center for cysteine thiol oxidation. The Journal of Biological Chemistry. 281: 18723-33. PMID 16611640 DOI: 10.1074/jbc.M601555200  1
2006 Wrenger C, Eschbach ML, Müller IB, Laun NP, Begley TP, Walter RD. Vitamin B1 de novo synthesis in the human malaria parasite Plasmodium falciparum depends on external provision of 4-amino-5-hydroxymethyl-2-methylpyrimidine. Biological Chemistry. 387: 41-51. PMID 16497163 DOI: 10.1515/BC.2006.007  1
2006 Sun G, Fecko CJ, Nicewonger RB, Webb WW, Begley TP. DNA-protein cross-linking: model systems for pyrimidine-aromatic amino acid cross-linking. Organic Letters. 8: 681-3. PMID 16468741 DOI: 10.1021/ol052876m  1
2006 Begley TP. Cofactor biosynthesis: an organic chemist's treasure trove. Natural Product Reports. 23: 15-25. PMID 16453030 DOI: 10.1039/b207131m  1
2006 Lehmann C, Begley TP, Ealick SE. Structure of the Escherichia coli ThiS-ThiF complex, a key component of the sulfur transfer system in thiamin biosynthesis. Biochemistry. 45: 11-9. PMID 16388576 DOI: 10.1021/bi051502y  1
2005 Begley TP. Chemical biology: an educational challenge for chemistry departments. Nature Chemical Biology. 1: 236-8. PMID 16408045 DOI: 10.1038/nchembio1005-236  1
2005 Colabroy KL, Begley TP. Tryptophan catabolism: identification and characterization of a new degradative pathway. Journal of Bacteriology. 187: 7866-9. PMID 16267312 DOI: 10.1128/JB.187.22.7866-7869.2005  1
2005 Overbeek R, Begley T, Butler RM, Choudhuri JV, Chuang HY, Cohoon M, de Crécy-Lagard V, Diaz N, Disz T, Edwards R, Fonstein M, Frank ED, Gerdes S, Glass EM, Goesmann A, et al. The subsystems approach to genome annotation and its use in the project to annotate 1000 genomes. Nucleic Acids Research. 33: 5691-702. PMID 16214803 DOI: 10.1093/nar/gki866  1
2005 Burns KE, Baumgart S, Dorrestein PC, Zhai H, McLafferty FW, Begley TP. Reconstitution of a new cysteine biosynthetic pathway in Mycobacterium tuberculosis. Journal of the American Chemical Society. 127: 11602-3. PMID 16104727 DOI: 10.1021/ja053476x  1
2005 Haas AL, Laun NP, Begley TP. Thi20, a remarkable enzyme from Saccharomyces cerevisiae with dual thiamin biosynthetic and degradation activities. Bioorganic Chemistry. 33: 338-44. PMID 15967475 DOI: 10.1016/j.bioorg.2005.04.001  1
2005 Zhai H, Dorrestein PC, Chatterjee A, Begley TP, McLafferty FW. Simultaneous kinetic characterization of multiple protein forms by top down mass spectrometry. Journal of the American Society For Mass Spectrometry. 16: 1052-9. PMID 15914018 DOI: 10.1016/j.jasms.2005.02.016  1
2005 Zhang Y, Colabroy KL, Begley TP, Ealick SE. Structural studies on 3-hydroxyanthranilate-3,4-dioxygenase: the catalytic mechanism of a complex oxidation involved in NAD biosynthesis. Biochemistry. 44: 7632-43. PMID 15909978 DOI: 10.1021/bi047353l  1
2005 Colabroy KL, Zhai H, Li T, Ge Y, Zhang Y, Liu A, Ealick SE, McLafferty FW, Begley TP. The mechanism of inactivation of 3-hydroxyanthranilate-3,4-dioxygenase by 4-chloro-3-hydroxyanthranilate. Biochemistry. 44: 7623-31. PMID 15909977 DOI: 10.1021/bi0473455  1
2005 Dorrestein P, Begley TP. Oxidative cascades: a facile biosynthetic strategy for the assembly of complex molecules. Bioorganic Chemistry. 33: 136-48. PMID 15888307 DOI: 10.1016/j.bioorg.2004.06.006  1
2005 Burns KE, Xiang Y, Kinsland CL, McLafferty FW, Begley TP. Reconstitution and biochemical characterization of a new pyridoxal-5'-phosphate biosynthetic pathway. Journal of the American Chemical Society. 127: 3682-3. PMID 15771487 DOI: 10.1021/ja042792t  1
2005 Toms AV, Haas AL, Park JH, Begley TP, Ealick SE. Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II. Biochemistry. 44: 2319-29. PMID 15709744 DOI: 10.1021/bi0478648  1
2005 Colabroy KL, Begley TP. The pyridine ring of NAD is formed by a nonenzymatic pericyclic reaction. Journal of the American Chemical Society. 127: 840-1. PMID 15656614 DOI: 10.1021/ja0446395  1
2005 Strauss E, Begley TP. The selectivity for cysteine over serine in coenzyme A biosynthesis. Chembiochem : a European Journal of Chemical Biology. 6: 284-6. PMID 15593134 DOI: 10.1002/cbic.200400340  1
2004 Strauss E, Zhai H, Brand LA, McLafferty FW, Begley TP. Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent. Biochemistry. 43: 15520-33. PMID 15581364 DOI: 10.1021/bi048340a  1
2004 Dorrestein PC, Zhai H, McLafferty FW, Begley TP. The biosynthesis of the thiazole phosphate moiety of thiamin: the sulfur transfer mediated by the sulfur carrier protein ThiS. Chemistry & Biology. 11: 1373-81. PMID 15489164 DOI: 10.1016/j.chembiol.2004.08.009  1
2004 Begley TP, Ealick SE. Enzymatic reactions involving novel mechanisms of carbanion stabilization. Current Opinion in Chemical Biology. 8: 508-15. PMID 15450493 DOI: 10.1016/j.cbpa.2004.08.004  1
2004 Settembre EC, Dorrestein PC, Zhai H, Chatterjee A, McLafferty FW, Begley TP, Ealick SE. Thiamin biosynthesis in Bacillus subtilis: structure of the thiazole synthase/sulfur carrier protein complex. Biochemistry. 43: 11647-57. PMID 15362849 DOI: 10.1021/bi0488911  1
2004 Lawhorn BG, Mehl RA, Begley TP. Biosynthesis of the thiamin pyrimidine: the reconstitution of a remarkable rearrangement reaction. Organic & Biomolecular Chemistry. 2: 2538-46. PMID 15326535 DOI: 10.1039/B405429F  1
2004 Lawhorn BG, Gerdes SY, Begley TP. A genetic screen for the identification of thiamin metabolic genes. The Journal of Biological Chemistry. 279: 43555-9. PMID 15292217 DOI: 10.1074/jbc.M404284200  1
2004 Melnick J, Lis E, Park JH, Kinsland C, Mori H, Baba T, Perkins J, Schyns G, Vassieva O, Osterman A, Begley TP. Identification of the two missing bacterial genes involved in thiamine salvage: thiamine pyrophosphokinase and thiamine kinase. Journal of Bacteriology. 186: 3660-2. PMID 15150256 DOI: 10.1128/JB.186.11.3660-3662.2004  1
2004 Dorrestein PC, Zhai H, Taylor SV, McLafferty FW, Begley TP. The biosynthesis of the thiazole phosphate moiety of thiamin (vitamin B1): the early steps catalyzed by thiazole synthase. Journal of the American Chemical Society. 126: 3091-6. PMID 15012138 DOI: 10.1021/ja039616p  1
2004 Park JH, Burns K, Kinsland C, Begley TP. Characterization of two kinases involved in thiamine pyrophosphate and pyridoxal phosphate biosynthesis in Bacillus subtilis: 4-amino-5-hydroxymethyl-2methylpyrimidine kinase and pyridoxal kinase. Journal of Bacteriology. 186: 1571-3. PMID 14973012 DOI: 10.1128/JB.186.5.1571-1573.2004  1
2004 Bauer JA, Bennett EM, Begley TP, Ealick SE. Three-dimensional structure of YaaE from Bacillus subtilis, a glutaminase implicated in pyridoxal-5'-phosphate biosynthesis. The Journal of Biological Chemistry. 279: 2704-11. PMID 14585832 DOI: 10.1074/jbc.M310311200  1
2003 Kurnasov O, Goral V, Colabroy K, Gerdes S, Anantha S, Osterman A, Begley TP. NAD biosynthesis: identification of the tryptophan to quinolinate pathway in bacteria. Chemistry & Biology. 10: 1195-204. PMID 14700627 DOI: 10.1016/j.chembiol.2003.11.011  1
2003 Settembre E, Begley TP, Ealick SE. Structural biology of enzymes of the thiamin biosynthesis pathway. Current Opinion in Structural Biology. 13: 739-47. PMID 14675553 DOI: 10.1016/j.sbi.2003.10.006  1
2003 Melnick JS, Sprinz KI, Reddick JJ, Kinsland C, Begley TP. An efficient enzymatic synthesis of thiamin pyrophosphate. Bioorganic & Medicinal Chemistry Letters. 13: 4139-41. PMID 14592524 DOI: 10.1016/j.bmcl.2003.07.026  1
2003 Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP. Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1). Biochemistry. 42: 12430-8. PMID 14567704 DOI: 10.1021/bi034902z  1
2003 Ge Y, Lawhorn BG, ElNaggar M, Sze SK, Begley TP, McLafferty FW. Detection of four oxidation sites in viral prolyl-4-hydroxylase by top-down mass spectrometry. Protein Science : a Publication of the Protein Society. 12: 2320-6. PMID 14500890 DOI: 10.1110/ps.03244403  1
2003 Manoj N, Strauss E, Begley TP, Ealick SE. Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution. Structure (London, England : 1993). 11: 927-36. PMID 12906824 DOI: 10.1016/S0969-2126(03)00146-1  1
2003 Dorrestein PC, Poole K, Begley TP. Formation of the chromophore of the pyoverdine siderophores by an oxidative cascade. Organic Letters. 5: 2215-7. PMID 12816412 DOI: 10.1021/ol034531e  1
2003 Maggio-Hall LA, Dorrestein PC, Escalante-Semerena JC, Begley TP. Formation of the dimethylbenzimidazole ligand of coenzyme B(12) under physiological conditions by a facile oxidative cascade. Organic Letters. 5: 2211-3. PMID 12816411 DOI: 10.1021/ol034530m  1
2003 Choudhry AE, Mandichak TL, Broskey JP, Egolf RW, Kinsland C, Begley TP, Seefeld MA, Ku TW, Brown JR, Zalacain M, Ratnam K. Inhibitors of pantothenate kinase: novel antibiotics for staphylococcal infections. Antimicrobial Agents and Chemotherapy. 47: 2051-5. PMID 12760898 DOI: 10.1128/AAC.47.6.2051-2055.2003  1
2003 Ge Y, El-Naggar M, Sze SK, Oh HB, Begley TP, McLafferty FW, Boshoff H, Barry CE. Top down characterization of secreted proteins from Mycobacterium tuberculosis by electron capture dissociation mass spectrometry. Journal of the American Society For Mass Spectrometry. 14: 253-61. PMID 12648932 DOI: 10.1016/S1044-0305(02)00913-3  1
2003 Settembre EC, Dorrestein PC, Park JH, Augustine AM, Begley TP, Ealick SE. Structural and mechanistic studies on ThiO, a glycine oxidase essential for thiamin biosynthesis in Bacillus subtilis. Biochemistry. 42: 2971-81. PMID 12627963 DOI: 10.1021/bi026916v  1
2003 Seravalli J, Gu W, Tam A, Strauss E, Begley TP, Cramer SP, Ragsdale SW. Functional copper at the acetyl-CoA synthase active site. Proceedings of the National Academy of Sciences of the United States of America. 100: 3689-94. PMID 12589021 DOI: 10.1073/pnas.0436720100  1
2003 Strauss E, Begley TP. Stereochemical studies on phosphopantothenoylcysteine decarboxylase from Escherichia coli. Bioorganic & Medicinal Chemistry Letters. 13: 339-42. PMID 12565925 DOI: 10.1016/S0960-894X(02)01018-1  1
2003 Begley TP, Tsai MD. Biocatalysis and biotransformation Enzymology in the genomics era Current Opinion in Chemical Biology. 7: 228-229. DOI: 10.1016/S1367-5931(03)00031-0  1
2002 Strauss E, Begley TP. The antibiotic activity of N-pentylpantothenamide results from its conversion to ethyldethia-coenzyme a, a coenzyme a antimetabolite. The Journal of Biological Chemistry. 277: 48205-9. PMID 12372838 DOI: 10.1074/jbc.M204560200  1
2002 Anand R, Dorrestein PC, Kinsland C, Begley TP, Ealick SE. Structure of oxalate decarboxylase from Bacillus subtilis at 1.75 A resolution. Biochemistry. 41: 7659-69. PMID 12056897 DOI: 10.1021/bi0200965  1
2002 Cheng G, Bennett EM, Begley TP, Ealick SE. Crystal structure of 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase from Salmonella typhimurium at 2.3 A resolution. Structure (London, England : 1993). 10: 225-35. PMID 11839308 DOI: 10.1016/S0969-2126(02)00708-6  1
2002 Ge Y, Lawhorn BG, ElNaggar M, Strauss E, Park JH, Begley TP, McLafferty FW. Top down characterization of larger proteins (45 kDa) by electron capture dissociation mass spectrometry. Journal of the American Chemical Society. 124: 672-8. PMID 11804498 DOI: 10.1021/ja011335z  1
2002 Mehl RA, Begley TP. Synthesis of 32P-labeled intermediates on the purine biosynthetic pathway Journal of Labelled Compounds and Radiopharmaceuticals. 45: 1097-1102. DOI: 10.1002/jlcr.627  1
2002 Ge Y, ElNaggar M, Boshoff H, Barry CE, Begley TP, McLafferty FW. Top down characterization of proteins by electron capture dissociation mass spectrometry: An application to the proteome of Mycobacterium tuberculosis Proceedings 50th Asms Conference On Mass Spectrometry and Allied Topics. 45-46.  1
2001 Reddick JJ, Saha S, Lee J, Melnick JS, Perkins J, Begley TP. The mechanism of action of bacimethrin, a naturally occurring thiamin antimetabolite. Bioorganic & Medicinal Chemistry Letters. 11: 2245-8. PMID 11527707 DOI: 10.1016/S0960-894X(01)00373-0  1
2001 Peapus DH, Chiu HJ, Campobasso N, Reddick JJ, Begley TP, Ealick SE. Structural characterization of the enzyme-substrate, enzyme-intermediate, and enzyme-product complexes of thiamin phosphate synthase. Biochemistry. 40: 10103-14. PMID 11513589 DOI: 10.1021/bi0104726  1
2001 Reddick JJ, Nicewonger R, Begley TP. Mechanistic studies on thiamin phosphate synthase: evidence for a dissociative mechanism. Biochemistry. 40: 10095-102. PMID 11513588 DOI: 10.1021/bi010267q  1
2001 Xi J, Ge Y, Kinsland C, McLafferty FW, Begley TP. Biosynthesis of the thiazole moiety of thiamin in Escherichia coli: identification of an acyldisulfide-linked protein--protein conjugate that is functionally analogous to the ubiquitin/E1 complex. Proceedings of the National Academy of Sciences of the United States of America. 98: 8513-8. PMID 11438688 DOI: 10.1073/pnas.141226698  1
2001 Strauss E, Begley TP. Mechanistic studies on phosphopantothenoylcysteine decarboxylase. Journal of the American Chemical Society. 123: 6449-50. PMID 11427085 DOI: 10.1021/ja016020y  1
2001 Strauss E, Kinsland C, Ge Y, McLafferty FW, Begley TP. Phosphopantothenoylcysteine synthetase from Escherichia coli. Identification and characterization of the last unidentified coenzyme A biosynthetic enzyme in bacteria. The Journal of Biological Chemistry. 276: 13513-6. PMID 11278255 DOI: 10.1074/jbc.C100033200  1
2001 Begley TP, Kinsland C, Strauss E. The biosynthesis of coenzyme A in bacteria. Vitamins and Hormones. 61: 157-71. PMID 11153265  1
2001 Begley TP, Kinsland C, Mehl RA, Osterman A, Dorrestein P. The biosynthesis of nicotinamide adenine dinucleotides in bacteria. Vitamins and Hormones. 61: 103-19. PMID 11153263  1
2001 Wang C, Xi J, Begley TP, Nicholson LK. Solution structure of ThiS and implications for the evolutionary roots of ubiquitin. Nature Structural Biology. 8: 47-51. PMID 11135670 DOI: 10.1038/83041  1
2000 Min W, Begley TP, Myllyharju J, Kivirikko KI. Mechanistic Studies on Prolyl-4-Hydroxylase: Demonstration That the Ferryl Intermediate Does Not Exchange with Water. Bioorganic Chemistry. 28: 261-265. PMID 11133144 DOI: 10.1006/bioo.2000.1182  1
2000 Begley TP, Appleby TC, Ealick SE. The structural basis for the remarkable catalytic proficiency of orotidine 5'-monophosphate decarboxylase. Current Opinion in Structural Biology. 10: 711-8. PMID 11114509 DOI: 10.1016/S0959-440X(00)00148-2  1
2000 Wu M, Moon HS, Pirskanen A, Myllyharju J, Kivirikko KI, Begley TP. Mechanistic studies on prolyl-4-hydroxylase: the vitamin C requiring uncoupled oxidation. Bioorganic & Medicinal Chemistry Letters. 10: 1511-4. PMID 10915038 DOI: 10.1016/S0960-894X(00)00224-9  1
2000 Mehl RA, Kinsland C, Begley TP. Identification of the Escherichia coli nicotinic acid mononucleotide adenylyltransferase gene. Journal of Bacteriology. 182: 4372-4. PMID 10894752 DOI: 10.1128/JB.182.15.4372-4374.2000  1
2000 Campobasso N, Mathews II, Begley TP, Ealick SE. Crystal structure of 4-methyl-5-beta-hydroxyethylthiazole kinase from Bacillus subtilis at 1.5 A resolution. Biochemistry. 39: 7868-77. PMID 10891066 DOI: 10.1021/bi0000061  1
2000 Appleby TC, Kinsland C, Begley TP, Ealick SE. The crystal structure and mechanism of orotidine 5'-monophosphate decarboxylase. Proceedings of the National Academy of Sciences of the United States of America. 97: 2005-10. PMID 10681442 DOI: 10.1073/pnas.259441296  1
2000 Wu M, Papish ET, Begley TP. Mechanistic studies on thiaminase I: Identification of the product of thiamin degradation in the absence of the nucleophilic cosubstrate Bioorganic Chemistry. 28: 45-48. DOI: 10.1006/bioo.1999.1156  1
2000 Wu M, Begley TP. β-scission of the N-O bond in alkyl hydroxamate radicals: A fast radical trap Organic Letters. 2: 1345-1348.  1
1999 Mehl RA, Begley TP. Mechanistic studies on the repair of a novel DNA photolesion: the spore photoproduct. Organic Letters. 1: 1065-6. PMID 10825958  1
1999 Begley TP, Xi J, Kinsland C, Taylor S, McLafferty F. The enzymology of sulfur activation during thiamin and biotin biosynthesis. Current Opinion in Chemical Biology. 3: 623-9. PMID 10508664 DOI: 10.1016/S1367-5931(99)00018-6  1
1999 Begley TP, Downs DM, Ealick SE, McLafferty FW, Van Loon AP, Taylor S, Campobasso N, Chiu HJ, Kinsland C, Reddick JJ, Xi J. Thiamin biosynthesis in prokaryotes. Archives of Microbiology. 171: 293-300. PMID 10382260 DOI: 10.1007/s002030050713  1
1999 Chiu HJ, Reddick JJ, Begley TP, Ealick SE. Crystal structure of thiamin phosphate synthase from Bacillus subtilis at 1.25 A resolution. Biochemistry. 38: 6460-70. PMID 10350464 DOI: 10.1021/bi982903z  1
1999 Wu M, Moon HS, Begley TP, Myllyharju J, Kivirikko KI. Mechanism-based inactivation of the human prolyl-4-hydroxylase by 5- oxaproline-containing peptides: Evidence for a prolyl radical intermediate Journal of the American Chemical Society. 121: 587-588. DOI: 10.1021/ja981193h  1
1998 Kinsland C, Taylor SV, Kelleher NL, McLafferty FW, Begley TP. Overexpression of recombinant proteins with a C-terminal thiocarboxylate: implications for protein semisynthesis and thiamin biosynthesis. Protein Science : a Publication of the Protein Society. 7: 1839-42. PMID 10082383 DOI: 10.1002/pro.5560070821  1
1998 Kelleher NL, Taylor SV, Grannis D, Kinsland C, Chiu HJ, Begley TP, McLafferty FW. Efficient sequence analysis of the six gene products (7-74 kDa) from the Escherichia coli thiamin biosynthetic operon by tandem high-resolution mass spectrometry. Protein Science : a Publication of the Protein Society. 7: 1796-801. PMID 10082377 DOI: 10.1002/pro.5560070815  1
1998 Tandon M, Wu M, Begley TP, Myllyharju J, Pirskanen A, Kivirikko K. Substrate specificity of human prolyl-4-hydroxylase. Bioorganic & Medicinal Chemistry Letters. 8: 1139-44. PMID 9871723 DOI: 10.1016/S0960-894X(98)00183-8  1
1998 Campobasso N, Costello CA, Kinsland C, Begley TP, Ealick SE. Crystal structure of thiaminase-I from Bacillus thiaminolyticus at 2.0 A resolution. Biochemistry. 37: 15981-9. PMID 9843405 DOI: 10.1021/bi981673l  1
1998 McLafferty FW, Kelleher NL, Begley TP, Fridriksson EK, Zubarev RA, Horn DM. Two-dimensional mass spectrometry of biomolecules at the subfemtomole level. Current Opinion in Chemical Biology. 2: 571-8. PMID 9818181  1
1998 Campobasso N, Begun J, Costello CA, Begley TP, Ealick SE. Crystallization and preliminary X-ray analysis of thiaminase I from Bacillus thiaminolyticus: space group change upon freezing of crystals. Acta Crystallographica. Section D, Biological Crystallography. 54: 448-50. PMID 9761925 DOI: 10.1107/S0907444997014157  0.8
1998 Rebeil R, Sun Y, Chooback L, Pedraza-Reyes M, Kinsland C, Begley TP, Nicholson WL. Spore photoproduct lyase from Bacillus subtilis spores is a novel iron-sulfur DNA repair enzyme which shares features with proteins such as class III anaerobic ribonucleotide reductases and pyruvate-formate lyases. Journal of Bacteriology. 180: 4879-85. PMID 9733691  1
1998 Taylor SV, Kelleher NL, Kinsland C, Chiu HJ, Costello CA, Backstrom AD, McLafferty FW, Begley TP. Thiamin biosynthesis in Escherichia coli. Identification of ThiS thiocarboxylate as the immediate sulfur donor in the thiazole formation. The Journal of Biological Chemistry. 273: 16555-60. PMID 9632726 DOI: 10.1074/jbc.273.26.16555  1
1998 Reddick JJ, Kinsland C, Nicewonger R, Christian T, Downs DM, Winkler ME, Begley TP. Overexpression, purification and characterization of two pyrimidine kinases involved in the biosynthesis of thiamin: 4-amino-5-hydroxymethyl-2- methylpyrimidine kinase and 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase Tetrahedron. 54: 15983-15991.  1
1998 Begley TP, Campobasso N, Costello C, Nicewonger R, Kelleher N, McLatferty F, Chiu I, Ealick S, Hang YZ, Reddick J, Kinesjand C. Mechanistic studies on thiamin formation and degradation: Thiaminase I and thiamin phosphate synthase Faseb Journal. 12: A1331.  1
1997 Kelleher NL, Nicewonger RB, Begley TP, McLafferty FW. Identification of modification sites in large biomolecules by stable isotope labeling and tandem high resolution mass spectrometry. The active site nucleophile of thiaminase I. The Journal of Biological Chemistry. 272: 32215-20. PMID 9405424 DOI: 10.1074/jbc.272.51.32215  1
1997 Sprenger GA, Schörken U, Wiegert T, Grolle S, de Graaf AA, Taylor SV, Begley TP, Bringer-Meyer S, Sahm H. Identification of a thiamin-dependent synthase in Escherichia coli required for the formation of the 1-deoxy-D-xylulose 5-phosphate precursor to isoprenoids, thiamin, and pyridoxol. Proceedings of the National Academy of Sciences of the United States of America. 94: 12857-62. PMID 9371765 DOI: 10.1073/pnas.94.24.12857  1
1997 Zhang Y, Begley TP. Cloning, sequencing and regulation of thiA, a thiamin biosynthesis gene from Bacillus subtilis. Gene. 198: 73-82. PMID 9370266 DOI: 10.1016/S0378-1119(97)00295-3  1
1997 Zhang Y, Taylor SV, Chiu HJ, Begley TP. Characterization of the Bacillus subtilis thiC operon involved in thiamine biosynthesis. Journal of Bacteriology. 179: 3030-5. PMID 9139923  1
1997 Nicewonger R, Begley TP. Synthesis of the spore photoproduct Tetrahedron Letters. 38: 935-936. DOI: 10.1016/S0040-4039(96)02517-8  1
1997 Begley TP. Mechanistic studies on the biosynthesis and degradation of thiamin Faseb Journal. 11: A1142.  1
1997 Tandon M, Begley TP. Selective deprotection of tert-butyldimethylsilyl ether with lithium bromide and 18-crown-6 Synthetic Communications. 27: 2953-2959.  1
1996 Nicewonger R, Costello CA, Begley TP. Mechanistic Studies on Thiaminase I. 3. Stereochemistry of the Thiaminase I and the Bisulfite-Catalyzed Degradation of Chiral Monodeuteriothiamin. The Journal of Organic Chemistry. 61: 4172-4174. PMID 11667304  1
1996 Begley TP. The biosynthesis and degradation of thiamin (vitamin B1). Natural Product Reports. 13: 177-85. PMID 8710215  1
1996 Costello CA, Kelleher NL, Abe M, McLafferty FW, Begley TP. Mechanistic studies on thiaminase I. Overexpression and identification of the active site nucleophile. The Journal of Biological Chemistry. 271: 3445-52. PMID 8631946 DOI: 10.1074/jbc.271.7.3445  1
1996 Nayar P, Begley TP. Protochlorophyllide reductase. III: Synthesis of a protochlorophyllide-dihydroflavin complex. Photochemistry and Photobiology. 63: 100-5. PMID 8577861 DOI: 10.1111/j.1751-1097.1996.tb02998.x  1
1995 Kelleher NL, Costello CA, Begley TP, McLafferty FW. Thiaminase I (42 kDa) heterogeneity, sequence refinement, and active site location from high-resolution tandem mass spectrometry. Journal of the American Society For Mass Spectrometry. 6: 981-4. PMID 24214043 DOI: 10.1016/1044-0305(95)00584-Z  1
1995 Backstrom AD, Austin R, McMordie S, Begley TP. A new synthesis of 1-deoxy-d-threo-2-pentulose a biosynthetic precursor to the thiazole moiety of thiamin Journal of Carbohydrate Chemistry. 14: 171-175. DOI: 10.1080/07328309508006444  1
1995 Nicewonger R, Rammelsberg A, Costello CA, Begley TP. Mechanistic studies on thiaminase I. 1. The stereochemical course of the reaction Bioorganic Chemistry. 23: 512-518. DOI: 10.1006/bioo.1995.1036  1
1995 Kim SJ, Lester C, Begley TP. Synthesis of the dinucleotide spore photoproduct Journal of Organic Chemistry. 60: 6256-6257.  1
1995 Backstrom AD, Austin R, McMordie S, Begley TP. Biosynthesis of thiamin I: The function of the thiE gene product Journal of the American Chemical Society. 117: 2351-2352.  1
1994 Begley TP. Photoenzymes: A novel class of biological catalysts Accounts of Chemical Research. 27: 394-400.  1
1993 Vander Horn PB, Backstrom AD, Stewart V, Begley TP. Structural genes for thiamine biosynthetic enzymes (thiCEFGH) in Escherichia coli K-12. Journal of Bacteriology. 175: 982-92. PMID 8432721  0.44
1993 Freeman JC, Nayar PG, Begley TP, Villafranca JJ. Stoichiometry and spectroscopic identity of copper centers in phenoxazinone synthase: a new addition to the blue copper oxidase family. Biochemistry. 32: 4826-30. PMID 8387816  1
1991 Witmer MR, Falcomer CM, Weiner MP, Kay MS, Begley TP, Ganem B, Scheraga HA. U-3'-BCIP: a chromogenic substrate for the detection of RNase A in recombinant DNA expression systems. Nucleic Acids Research. 19: 1-4. PMID 2011489 DOI: 10.1093/nar/19.1.1  1
1989 Barry CE, Nayar PG, Begley TP. Phenoxazinone synthase: mechanism for the formation of the phenoxazinone chromophore of actinomycin. Biochemistry. 28: 6323-33. PMID 2477054  0.56
1987 Wackett LP, Honek JF, Begley TP, Wallace V, Orme-Johnson WH, Walsh CT. Substrate analogues as mechanistic probes of methyl-S-coenzyme M reductase. Biochemistry. 26: 6012-8. PMID 3120769  1
1986 Begley TP, Walts AE, Walsh CT. Mechanistic studies of a protonolytic organomercurial cleaving enzyme: bacterial organomercurial lyase. Biochemistry. 25: 7192-200. PMID 3542022  0.68
1986 Begley TP, Walts AE, Walsh CT. Bacterial organomercurial lyase: overproduction, isolation, and characterization. Biochemistry. 25: 7186-92. PMID 3542021  0.68
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