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Paul K. Kiptoo, Ph.D. - Publications

Affiliations: 
2007 University of Kentucky, Lexington, KY 
Area:
Pharmaceutical Chemistry
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25 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Kopec BM, Kiptoo P, Zhao L, Rosa-Molinar E, Siahaan TJ. Non-Invasive Brain Delivery and Efficacy of BDNF to Stimulate Neuroregeneration and Suppression of Disease Relapse in EAE Mice. Molecular Pharmaceutics. PMID 31846344 DOI: 10.1021/Acs.Molpharmaceut.9B00644  0.332
2019 Singh RK, van Haandel L, Kiptoo P, Becker ML, Siahaan TJ, Funk RS. Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model. European Journal of Pharmacology. PMID 30951714 DOI: 10.1016/J.Ejphar.2019.03.052  0.314
2017 White DR, Khedri Z, Kiptoo P, Siahaan TJ, Tolbert TJ. Synthesis of a Bifunctional Peptide Inhibitor-IgG1 Fc Fusion that Suppresses Experimental Autoimmune Encephalomyelitis. Bioconjugate Chemistry. PMID 28581731 DOI: 10.1021/Acs.Bioconjchem.7B00175  0.35
2016 Alaofi A, On N, Kiptoo P, Williams TD, Miller DW, Siahaan TJ. Comparison of Linear and Cyclic His-Ala-Val Peptides in Modulating the Blood-Brain Barrier Permeability: Impact on Delivery of Molecules to the Brain. Journal of Pharmaceutical Sciences. 105: 797-807. PMID 26869430 DOI: 10.1016/S0022-3549(15)00188-4  0.381
2015 Tabanor K, Lee P, Kiptoo P, Choi IY, Sherry EB, Eagle CS, Williams TD, Siahaan TJ. Brain Delivery of Drug and MRI Contrast Agent: Detection and Quantitative Determination of Brain Deposition of CPT-Glu Using LC-MS/MS and Gd-DTPA Using Magnetic Resonance Imaging. Molecular Pharmaceutics. PMID 26705088 DOI: 10.1021/Acs.Molpharmaceut.5B00607  0.344
2015 Badawi AH, Kiptoo P, Siahaan TJ. Immune Tolerance Induction against Experimental Autoimmune Encephalomyelitis (EAE) Using A New PLP-B7AP Conjugate that Simultaneously Targets B7/CD28 Costimulatory Signal and TCR/MHC-II Signal. Journal of Multiple Sclerosis. 2. PMID 26140285 DOI: 10.4172/2376-0389.1000131  0.324
2015 Laksitorini MD, Kiptoo PK, On NH, Thliveris JA, Miller DW, Siahaan TJ. Modulation of intercellular junctions by cyclic-ADT peptides as a method to reversibly increase blood-brain barrier permeability. Journal of Pharmaceutical Sciences. 104: 1065-75. PMID 25640479 DOI: 10.1002/Jps.24309  0.352
2014 Büyüktimkin B, Kiptoo P, Siahaan TJ. Bifunctional Peptide Inhibitors Suppress Interleukin-6 Proliferation and Ameliorates Murine Collagen-Induced Arthritis. Journal of Clinical & Cellular Immunology. 5. PMID 26251760 DOI: 10.4172/2155-9899.1000273  0.338
2014 Laksitorini M, Prasasty VD, Kiptoo PK, Siahaan TJ. Pathways and progress in improving drug delivery through the intestinal mucosa and blood-brain barriers. Therapeutic Delivery. 5: 1143-63. PMID 25418271 DOI: 10.4155/Tde.14.67  0.354
2014 On NH, Kiptoo P, Siahaan TJ, Miller DW. Modulation of blood-brain barrier permeability in mice using synthetic E-cadherin peptide. Molecular Pharmaceutics. 11: 974-81. PMID 24495091 DOI: 10.1021/Mp400624V  0.366
2013 Kiptoo P, Büyüktimkin B, Badawi AH, Stewart J, Ridwan R, Siahaan TJ. Controlling immune response and demyelination using highly potent bifunctional peptide inhibitors in the suppression of experimental autoimmune encephalomyelitis. Clinical and Experimental Immunology. 172: 23-36. PMID 23480182 DOI: 10.1111/Cei.12029  0.352
2013 Büyüktimkin B, Manikwar P, Kiptoo PK, Badawi AH, Stewart JM, Siahaan TJ. Vaccinelike and prophylactic treatments of EAE with novel I-domain antigen conjugates (IDAC): targeting multiple antigenic peptides to APC. Molecular Pharmaceutics. 10: 297-306. PMID 23148513 DOI: 10.1021/Mp300440X  0.336
2012 Büyüktimkin B, Wang Q, Kiptoo P, Stewart JM, Berkland C, Siahaan TJ. Vaccine-like controlled-release delivery of an immunomodulating peptide to treat experimental autoimmune encephalomyelitis. Molecular Pharmaceutics. 9: 979-85. PMID 22375937 DOI: 10.1021/Mp200614Q  0.319
2012 Manikwar P, Büyüktimkin B, Kiptoo P, Badawi AH, Galeva NA, Williams TD, Siahaan TJ. I-domain-antigen conjugate (IDAC) for delivering antigenic peptides to APC: synthesis, characterization, and in vivo EAE suppression. Bioconjugate Chemistry. 23: 509-17. PMID 22369638 DOI: 10.1021/Bc200580J  0.322
2012 Badawi AH, Kiptoo P, Wang WT, Choi IY, Lee P, Vines CM, Siahaan TJ. Suppression of EAE and prevention of blood-brain barrier breakdown after vaccination with novel bifunctional peptide inhibitor. Neuropharmacology. 62: 1874-81. PMID 22210333 DOI: 10.1016/J.Neuropharm.2011.12.013  0.342
2011 Kiptoo P, Sinaga E, Calcagno AM, Zhao H, Kobayashi N, Tambunan US, Siahaan TJ. Enhancement of drug absorption through the blood-brain barrier and inhibition of intercellular tight junction resealing by E-cadherin peptides. Molecular Pharmaceutics. 8: 239-49. PMID 21128658 DOI: 10.1021/Mp100293M  0.366
2010 Ridwan R, Kiptoo P, Kobayashi N, Weir S, Hughes M, Williams T, Soegianto R, Siahaan TJ. Antigen-specific suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor: structure optimization and pharmacokinetics. The Journal of Pharmacology and Experimental Therapeutics. 332: 1136-45. PMID 20026673 DOI: 10.1124/Jpet.109.161109  0.36
2010 Zhao H, Kiptoo P, Williams TD, Siahaan TJ, Topp EM. Immune response to controlled release of immunomodulating peptides in a murine experimental autoimmune encephalomyelitis (EAE) model. Journal of Controlled Release : Official Journal of the Controlled Release Society. 141: 145-52. PMID 19748537 DOI: 10.1016/J.Jconrel.2009.09.002  0.334
2009 Kiptoo PK, Paudel KS, Hammell DC, Pinninti RR, Chen J, Crooks PA, Stinchcomb AL. Transdermal delivery of bupropion and its active metabolite, hydroxybupropion: a prodrug strategy as an alternative approach. Journal of Pharmaceutical Sciences. 98: 583-94. PMID 18623203 DOI: 10.1002/Jps.21463  0.624
2008 Kobayashi N, Kiptoo P, Kobayashi H, Ridwan R, Brocke S, Siahaan TJ. Prophylactic and therapeutic suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor. Clinical Immunology (Orlando, Fla.). 129: 69-79. PMID 18676182 DOI: 10.1016/J.Clim.2008.06.002  0.334
2008 Kiptoo PK, Paudel KS, Hammell DC, Hamad MO, Crooks PA, Stinchcomb AL. In vivo evaluation of a transdermal codrug of 6-beta-naltrexol linked to hydroxybupropion in hairless guinea pigs. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 33: 371-9. PMID 18321686 DOI: 10.1016/J.Ejps.2008.01.006  0.615
2006 Hamad MO, Kiptoo PK, Stinchcomb AL, Crooks PA. Synthesis and hydrolytic behavior of two novel tripartate codrugs of naltrexone and 6beta-naltrexol with hydroxybupropion as potential alcohol abuse and smoking cessation agents. Bioorganic & Medicinal Chemistry. 14: 7051-61. PMID 16798000 DOI: 10.1016/J.Bmc.2006.06.018  0.556
2006 Kiptoo PK, Hamad MO, Crooks PA, Stinchcomb AL. Enhancement of transdermal delivery of 6-beta-naltrexol via a codrug linked to hydroxybupropion. Journal of Controlled Release : Official Journal of the Controlled Release Society. 113: 137-45. PMID 16750868 DOI: 10.1016/J.Jconrel.2006.04.003  0.642
2005 Paudel KS, Nalluri BN, Hammell DC, Valiveti S, Kiptoo P, Hamad MO, Crooks PA, Stinchcomb AL. Transdermal delivery of naltrexone and its active metabolite 6-beta-naltrexol in human skin in vitro and guinea pigs in vivo. Journal of Pharmaceutical Sciences. 94: 1965-75. PMID 16052561 DOI: 10.1002/Jps.20398  0.656
2004 Valiveti S, Kiptoo PK, Hammell DC, Stinchcomb AL. Transdermal permeation of WIN 55,212-2 and CP 55,940 in human skin in vitro. International Journal of Pharmaceutics. 278: 173-80. PMID 15158959 DOI: 10.1016/J.Ijpharm.2004.03.009  0.629
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