Frances H. Arnold - Publications

Affiliations: 
California Institute of Technology, Pasadena, CA 
Area:
Protein engineering, directed protein evolution, structure-guided protein recombination, biocatalysis, biofuels
Website:
http://www.che.caltech.edu/faculty/arnold_f/index.html

262 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Yang KK, Wu Z, Arnold FH. Machine-learning-guided directed evolution for protein engineering. Nature Methods. PMID 31308553 DOI: 10.1038/s41592-019-0496-6  0.32
2019 Zhang J, Huang X, Zhang RK, Arnold FH. Enantiodivergent α-Amino C-H Fluoroalkylation Catalyzed by Engineered Cytochrome P450s. Journal of the American Chemical Society. PMID 31187993 DOI: 10.1021/jacs.9b04344  0.72
2019 Brandenberg OF, Chen K, Arnold FH. Directed Evolution of a Cytochrome P450 Carbene Transferase for Selective Functionalization of Cyclic Compounds. Journal of the American Chemical Society. PMID 31070908 DOI: 10.1021/jacs.9b02931  1
2019 Wu Z, Kan SBJ, Lewis RD, Wittmann BJ, Arnold FH. Machine learning-assisted directed protein evolution with combinatorial libraries. Proceedings of the National Academy of Sciences of the United States of America. PMID 30979809 DOI: 10.1073/pnas.1901979116  0.72
2019 Chen K, Huang X, Zhang SQ, Zhou AZ, Kan SBJ, Hong X, Arnold FH. Engineered Cytochrome -Catalyzed Lactone-Carbene B-H Insertion. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 30: 378-382. PMID 30930550 DOI: 10.1055/s-0037-1611662  1
2019 Huang X, Garcia-Borràs M, Miao K, Kan SBJ, Zutshi A, Houk KN, Arnold FH. A Biocatalytic Platform for Synthesis of Chiral Trifluoromethylated Organoborons. Acs Central Science. 5: 270-276. PMID 30834315 DOI: 10.1021/acscentsci.8b00679  0.72
2019 Sa G, Yao J, Deng C, Liu J, Zhang Y, Zhu Z, Zhang Y, Ma X, Zhao R, Lin S, Lu C, Polle A, Chen S. Amelioration of nitrate uptake under salt stress by ectomycorrhiza with and without a Hartig net. The New Phytologist. PMID 30756398 DOI: 10.1111/nph.15740  0.36
2019 Wang H, Wei W, Lan X, Liu N, Li Y, Ma H, Sun T, Peng X, Zhuang C, Yu JQ. Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway. Acs Chemical Neuroscience. PMID 30753053 DOI: 10.1021/acschemneuro.8b00605  0.36
2019 Liao CH, Chen WH, Liao NC, Tsuei YS. CTA-guided outflow-targeted embolization of direct carotid-cavernous fistula. Neurosurgical Focus. 46: V11. PMID 30611182 DOI: 10.3171/2019.1.FocusVid.18447  0.32
2019 Cho I, Prier CK, Jia ZJ, Zhang RK, Görbe T, Arnold FH. Enantioselective Aminohydroxylation of Styrenyl Olefins Catalyzed by an Engineered Hemoprotein. Angewandte Chemie (International Ed. in English). PMID 30600873 DOI: 10.1002/anie.201812968  0.68
2018 Zhang RK, Chen K, Huang X, Wohlschlager L, Renata H, Arnold FH. Enzymatic assembly of carbon-carbon bonds via iron-catalysed sp C-H functionalization. Nature. PMID 30568304 DOI: 10.1038/s41586-018-0808-5  1
2018 Molakarimi M, Gorman MA, Mohseni A, Pashandi Z, Taghdir M, Naderi-Manesh H, Sajedi RH, Parker MW. Reaction mechanism of the bioluminescent protein mnemiopsin1 revealed by X-ray crystallography and QM/MM simulations. The Journal of Biological Chemistry. PMID 30420427 DOI: 10.1074/jbc.RA118.006053  0.52
2018 Chen K, Zhang SQ, Brandenberg OF, Hong X, Arnold FH. Alternate heme ligation steers activity and selectivity in engineered cytochrome P450-catalyzed carbene transfer reactions. Journal of the American Chemical Society. PMID 30372623 DOI: 10.1021/jacs.8b09613  1
2018 Zhang RK, Huang X, Arnold FH. Selective CH bond functionalization with engineered heme proteins: new tools to generate complexity. Current Opinion in Chemical Biology. 49: 67-75. PMID 30343008 DOI: 10.1016/j.cbpa.2018.10.004  0.72
2018 Almhjell PJ, Boville CE, Arnold FH. Engineering enzymes for noncanonical amino acid synthesis. Chemical Society Reviews. PMID 30280154 DOI: 10.1039/c8cs00665b  0.6
2018 Boville CE, Scheele RA, Koch P, Brinkmann-Chen S, Buller AR, Arnold FH. Engineered biosynthesis of β-alkyl tryptophan analogs. Angewandte Chemie (International Ed. in English). PMID 30215880 DOI: 10.1002/anie.201807998  0.8
2018 Romney DK, Arnold FH, Lipshutz BH, Li CJ. Chemistry Takes a Bath: Reactions in Aqueous Media. The Journal of Organic Chemistry. 83: 7319-7322. PMID 30025465 DOI: 10.1021/acs.joc.8b01412  0.68
2018 Lewis RD, Garcia-Borràs M, Chalkley MJ, Buller AR, Houk KN, Kan SBJ, Arnold FH. Catalytic iron-carbene intermediate revealed in a cytochrome carbene transferase. Proceedings of the National Academy of Sciences of the United States of America. PMID 29946033 DOI: 10.1073/pnas.1807027115  0.8
2018 Yang KK, Wu Z, Bedbrook CN, Arnold FH. Learned protein embeddings for machine learning. Bioinformatics (Oxford, England). PMID 29933431 DOI: 10.1093/bioinformatics/bty455  0.4
2018 Jin T, Brefo-Mensah E, Fan W, Zeng W, Li Y, Zhang Y, Palmer M. Crystal structure of the CAMP factor, and insights into its membrane-permeabilizing activity. The Journal of Biological Chemistry. PMID 29884770 DOI: 10.1074/jbc.RA118.002336  0.36
2018 Buller AR, van Roye P, Cahn JKB, Scheele RA, Herger M, Arnold FH. Directed evolution mimics allosteric activation by stepwise tuning of the conformational ensemble. Journal of the American Chemical Society. PMID 29712420 DOI: 10.1021/jacs.8b03490  0.8
2018 Boville CE, Romney DK, Almhjell PJ, Sieben M, Arnold FH. Improved synthesis of 4-cyanotryptophan and other tryptophan analogs in aqueous solvent using variants of TrpB from Thermotoga maritima. The Journal of Organic Chemistry. PMID 29651849 DOI: 10.1021/acs.joc.8b00517  0.68
2018 Knight AM, Kan SBJ, Lewis RD, Brandenberg OF, Chen K, Arnold FH. Diverse Engineered Heme Proteins Enable Stereodivergent Cyclopropanation of Unactivated Alkenes. Acs Central Science. 4: 372-377. PMID 29632883 DOI: 10.1021/acscentsci.7b00548  1
2018 Chen K, Huang X, Kan SBJ, Zhang RK, Arnold FH. Enzymatic construction of highly strained carbocycles. Science (New York, N.Y.). 360: 71-75. PMID 29622650 DOI: 10.1126/science.aar4239  1
2018 Yang KK, Wu Z, Bedbrook CN, Arnold FH. Learned Protein Embeddings for Machine Learning. Bioinformatics (Oxford, England). PMID 29584811 DOI: 10.1093/bioinformatics/bty178  0.4
2018 Cahn JKB, Brinkmann-Chen S, Arnold FH. Enzyme Nicotinamide Cofactor Specificity Reversal Guided by Automated Structural Analysis and Library Design. Methods in Molecular Biology (Clifton, N.J.). 1671: 15-26. PMID 29170950 DOI: 10.1007/978-1-4939-7295-1_2  0.8
2017 Kan SBJ, Huang X, Gumulya Y, Chen K, Arnold FH. Genetically programmed chiral organoborane synthesis. Nature. 552: 132-136. PMID 29186119 DOI: 10.1038/nature24996  1
2017 Bedbrook CN, Yang KK, Rice AJ, Gradinaru V, Arnold FH. Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization. Plos Computational Biology. 13: e1005786. PMID 29059183 DOI: 10.1371/journal.pcbi.1005786  0.4
2017 Loskot SA, Romney DK, Arnold FH, Stoltz BM. Enantioselective Total Synthesis of Nigelladine A via Late-Stage C-H Oxidation Enabled by an Engineered P450 Enzyme. Journal of the American Chemical Society. PMID 28721734 DOI: 10.1021/jacs.7b05196  0.68
2017 Brandenberg OF, Fasan R, Arnold FH. Exploiting and engineering hemoproteins for abiological carbene and nitrene transfer reactions. Current Opinion in Biotechnology. 47: 102-111. PMID 28711855 DOI: 10.1016/j.copbio.2017.06.005  1
2017 Romney DK, Murciano-Calles J, Wehrmüller JE, Arnold FH. Unlocking reactivity of TrpB: a general biocatalytic platform for synthesis of tryptophan analogs. Journal of the American Chemical Society. PMID 28708383 DOI: 10.1021/jacs.7b05007  0.68
2017 Prier CK, Zhang RK, Buller AR, Brinkmann-Chen S, Arnold FH. Enantioselective, intermolecular benzylic C-H amination catalysed by an engineered iron-haem enzyme. Nature Chemistry. 9: 629-634. PMID 28644476 DOI: 10.1038/nchem.2783  0.8
2017 Bedbrook CN, Rice AJ, Yang KK, Ding X, Chen S, LeProust EM, Gradinaru V, Arnold FH. Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins. Proceedings of the National Academy of Sciences of the United States of America. PMID 28283661 DOI: 10.1073/pnas.1700269114  0.4
2017 Herwig L, Rice AJ, Bedbrook CN, Zhang RK, Lignell A, Cahn JK, Renata H, Dodani SC, Cho I, Cai L, Gradinaru V, Arnold FH. Directed Evolution of a Bright Near-Infrared Fluorescent Rhodopsin Using a Synthetic Chromophore. Cell Chemical Biology. PMID 28262559 DOI: 10.1016/j.chembiol.2017.02.008  0.8
2016 Hernandez KE, Renata H, Lewis RD, Jennifer Kan SB, Zhang C, Forte J, Rozzell D, McIntosh JA, Arnold FH. Highly Stereoselective Biocatalytic Synthesis of Key Cyclopropane Intermediate to Ticagrelor. Acs Catalysis. 6: 7810-7813. PMID 28286694 DOI: 10.1021/acscatal.6b02550  0.8
2016 Buller AR, van Roye P, Murciano-Calles J, Arnold FH. Tryptophan Synthase Uses an Atypical Mechanism To Achieve Substrate Specificity. Biochemistry. PMID 27935677 DOI: 10.1021/acs.biochem.6b01127  0.8
2016 Kan SB, Lewis RD, Chen K, Arnold FH. Directed evolution of cytochrome c for carbon-silicon bond formation: Bringing silicon to life. Science (New York, N.Y.). 354: 1048-1051. PMID 27885032 DOI: 10.1126/science.aah6219  1
2016 Cahn JK, Werlang CA, Baumschlager A, Brinkmann-Chen S, Mayo SL, Arnold FH. A general tool for engineering the NAD/NADP cofactor preference of oxidoreductases. Acs Synthetic Biology. PMID 27648601 DOI: 10.1021/acssynbio.6b00188  0.92
2016 Renata H, Lewis RD, Sweredoski MJ, Moradian A, Hess S, Wang ZJ, Arnold FH. Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes. Journal of the American Chemical Society. PMID 27573353 DOI: 10.1021/jacs.6b06823  1
2016 Murciano-Calles J, Romney DK, Brinkmann-Chen S, Buller AR, Arnold FH. A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation. Angewandte Chemie (International Ed. in English). PMID 27510733 DOI: 10.1002/anie.201606242  0.8
2016 Moraïs S, Stern J, Kahn A, Galanopoulou AP, Yoav S, Shamshoum M, Smith MA, Hatzinikolaou DG, Arnold FH, Bayer EA. Enhancement of cellulosome-mediated deconstruction of cellulose by improving enzyme thermostability. Biotechnology For Biofuels. 9: 164. PMID 27493686 DOI: 10.1186/s13068-016-0577-z  1
2016 Herger M, van Roye P, Romney DK, Brinkmann-Chen S, Buller AR, Arnold FH. Synthesis of β-branched tryptophan analogs using an engineered subunit of tryptophan synthase. Journal of the American Chemical Society. PMID 27355405 DOI: 10.1021/jacs.6b04836  0.8
2016 Dodani SC, Kiss G, Cahn JK, Su Y, Pande VS, Arnold FH. Discovery of a regioselectivity switch in nitrating P450s guided by molecular dynamics simulations and Markov models. Nature Chemistry. 8: 419-25. PMID 27102675 DOI: 10.1038/nchem.2474  1
2016 Prier CK, Hyster TK, Farwell CC, Huang A, Arnold FH. Asymmetric Enzymatic Synthesis of Allylic Amines: A Sigmatropic Rearrangement Strategy. Angewandte Chemie (International Ed. in English). PMID 26970325 DOI: 10.1002/anie.201601056  1
2015 Cahn JK, Brinkmann-Chen S, Buller AR, Arnold FH. Artificial domain duplication replicates evolutionary history of ketol-acid reductoisomerases. Protein Science : a Publication of the Protein Society. PMID 26644020 DOI: 10.1002/pro.2852  0.8
2015 Buller AR, Brinkmann-Chen S, Romney DK, Herger M, Murciano-Calles J, Arnold FH. Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 26553994 DOI: 10.1073/pnas.1516401112  1
2015 Arnold FH. The nature of chemical innovation: new enzymes by evolution. Quarterly Reviews of Biophysics. 48: 404-10. PMID 26537398 DOI: 10.1017/S003358351500013X  1
2015 Cahn JK, Baumschlager A, Brinkmann-Chen S, Arnold FH. Mutations in adenine-binding pockets enhance catalytic properties of NAD(P)H-dependent enzymes. Protein Engineering, Design & Selection : Peds. PMID 26512129 DOI: 10.1093/protein/gzv057  1
2015 Prier CK, Arnold FH. Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts. Journal of the American Chemical Society. PMID 26502343 DOI: 10.1021/jacs.5b09348  1
2015 Farwell CC, Zhang RK, McIntosh JA, Hyster TK, Arnold FH. Enantioselective Enzyme-Catalyzed Aziridination Enabled by Active-Site Evolution of a Cytochrome P450. Acs Central Science. 1: 89-93. PMID 26405689 DOI: 10.1021/acscentsci.5b00056  1
2015 McIntosh JA, Heel T, Buller AR, Chio L, Arnold FH. Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450. Journal of the American Chemical Society. PMID 26299431 DOI: 10.1021/jacs.5b07107  1
2015 Bedbrook CN, Kato M, Ravindra Kumar S, Lakshmanan A, Nath RD, Sun F, Sternberg PW, Arnold FH, Gradinaru V. Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo. Chemistry & Biology. 22: 1108-21. PMID 26211362 DOI: 10.1016/j.chembiol.2015.06.020  0.4
2015 McIsaac RS, Bedbrook CN, Arnold FH. Recent advances in engineering microbial rhodopsins for optogenetics. Current Opinion in Structural Biology. 33: 8-15. PMID 26038227 DOI: 10.1016/j.sbi.2015.05.001  1
2015 Cahn JK, Brinkmann-Chen S, Spatzal T, Wiig JA, Buller AR, Einsle O, Hu Y, Ribbe MW, Arnold FH. Cofactor specificity motifs and the induced fit mechanism in Class I ketol-acid reductoisomerases. The Biochemical Journal. PMID 25849365 DOI: 10.1042/BJ20150183  1
2015 Renata H, Wang ZJ, Arnold FH. Expanding the enzyme universe: accessing non-natural reactions by mechanism-guided directed evolution. Angewandte Chemie (International Ed. in English). 54: 3351-67. PMID 25649694 DOI: 10.1002/anie.201409470  1
2015 Engqvist MK, McIsaac RS, Dollinger P, Flytzanis NC, Abrams M, Schor S, Arnold FH. Directed evolution of Gloeobacter violaceus rhodopsin spectral properties. Journal of Molecular Biology. 427: 205-20. PMID 24979679 DOI: 10.1016/j.jmb.2014.06.015  1
2015 Bedbrook CN, Kato M, Ravindra kumar S, Lakshmanan A, Nath RD, Sun F, Sternberg PW, Arnold FH, Gradinaru V. Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo Chemistry and Biology. 22: 1108-1121. DOI: 10.1016/j.chembiol.2015.06.020  1
2015 Hyster TK, Arnold FH. P450BM3-axial mutations: A gateway to non-natural reactivity Israel Journal of Chemistry. 55: 14-20. DOI: 10.1002/ijch.201400080  1
2014 Hyster TK, Farwell CC, Buller AR, McIntosh JA, Arnold FH. Enzyme-controlled nitrogen-atom transfer enables regiodivergent C-H amination. Journal of the American Chemical Society. 136: 15505-8. PMID 25325618 DOI: 10.1021/ja509308v  1
2014 Heel T, McIntosh JA, Dodani SC, Meyerowitz JT, Arnold FH. Non-natural olefin cyclopropanation catalyzed by diverse cytochrome P450s and other hemoproteins. Chembiochem : a European Journal of Chemical Biology. 15: 2556-62. PMID 25294253 DOI: 10.1002/cbic.201402286  1
2014 Flytzanis NC, Bedbrook CN, Chiu H, Engqvist MK, Xiao C, Chan KY, Sternberg PW, Arnold FH, Gradinaru V. Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons. Nature Communications. 5: 4894. PMID 25222271 DOI: 10.1038/ncomms5894  0.4
2014 Renata H, Wang ZJ, Kitto RZ, Arnold FH. P450-catalyzed asymmetric cyclopropanation of electron-deficient olefins under aerobic conditions. Catalysis Science & Technology. 4: 3640-3643. PMID 25221671 DOI: 10.1039/C4CY00633J  1
2014 Dodani SC, Cahn JK, Heinisch T, Brinkmann-Chen S, McIntosh JA, Arnold FH. Structural, functional, and spectroscopic characterization of the substrate scope of the novel nitrating cytochrome P450 TxtE. Chembiochem : a European Journal of Chemical Biology. 15: 2259-67. PMID 25182183 DOI: 10.1002/cbic.201402241  1
2014 Brinkmann-Chen S, Cahn JK, Arnold FH. Uncovering rare NADH-preferring ketol-acid reductoisomerases. Metabolic Engineering. 26: 17-22. PMID 25172159 DOI: 10.1016/j.ymben.2014.08.003  1
2014 Berland M, Offmann B, André I, Remaud-Siméon M, Charton P. A web-based tool for rational screening of mutants libraries using ProSAR. Protein Engineering, Design & Selection : Peds. 27: 375-81. PMID 25169579 DOI: 10.1093/protein/gzu035  1
2014 McIsaac RS, Engqvist MK, Wannier T, Rosenthal AZ, Herwig L, Flytzanis NC, Imasheva ES, Lanyi JK, Balashov SP, Gradinaru V, Arnold FH. Directed evolution of a far-red fluorescent rhodopsin. Proceedings of the National Academy of Sciences of the United States of America. 111: 13034-9. PMID 25157169 DOI: 10.1073/pnas.1413987111  1
2014 Smith MA, Arnold FH. Noncontiguous SCHEMA protein recombination. Methods in Molecular Biology (Clifton, N.J.). 1179: 345-52. PMID 25055789 DOI: 10.1007/978-1-4939-1053-3_23  1
2014 Smith MA, Arnold FH. Designing libraries of chimeric proteins using SCHEMA recombination and RASPP. Methods in Molecular Biology (Clifton, N.J.). 1179: 335-43. PMID 25055788 DOI: 10.1007/978-1-4939-1053-3_22  1
2014 Sun F, Zhang WB, Mahdavi A, Arnold FH, Tirrell DA. Synthesis of bioactive protein hydrogels by genetically encoded SpyTag-SpyCatcher chemistry. Proceedings of the National Academy of Sciences of the United States of America. 111: 11269-74. PMID 25049400 DOI: 10.1073/pnas.1401291111  1
2014 Trudeau DL, Lee TM, Arnold FH. Engineered thermostable fungal cellulases exhibit efficient synergistic cellulose hydrolysis at elevated temperatures. Biotechnology and Bioengineering. 111: 2390-7. PMID 24916885 DOI: 10.1002/bit.25308  1
2014 Farwell CC, McIntosh JA, Hyster TK, Wang ZJ, Arnold FH. Enantioselective imidation of sulfides via enzyme-catalyzed intermolecular nitrogen-atom transfer. Journal of the American Chemical Society. 136: 8766-71. PMID 24901646 DOI: 10.1021/ja503593n  1
2014 Silver PA, Way JC, Arnold FH, Meyerowitz JT. Synthetic biology: Engineering explored. Nature. 509: 166-7. PMID 24805338 DOI: 10.1038/509166a  1
2014 Wang ZJ, Renata H, Peck NE, Farwell CC, Coelho PS, Arnold FH. Improved cyclopropanation activity of histidine-ligated cytochrome P450 enables the enantioselective formal synthesis of levomilnacipran. Angewandte Chemie (International Ed. in English). 53: 6810-3. PMID 24802161 DOI: 10.1002/anie.201402809  1
2014 Lin PP, Rabe KS, Takasumi JL, Kadisch M, Arnold FH, Liao JC. Isobutanol production at elevated temperatures in thermophilic Geobacillus thermoglucosidasius. Metabolic Engineering. 24: 1-8. PMID 24721011 DOI: 10.1016/j.ymben.2014.03.006  1
2014 McIntosh JA, Farwell CC, Arnold FH. Expanding P450 catalytic reaction space through evolution and engineering. Current Opinion in Chemical Biology. 19: 126-34. PMID 24658056 DOI: 10.1016/j.cbpa.2014.02.001  1
2014 Wang ZJ, Peck NE, Renata H, Arnold FH. Cytochrome P450-Catalyzed Insertion of Carbenoids into N-H Bonds. Chemical Science (Royal Society of Chemistry : 2010). 5: 598-601. PMID 24490022 DOI: 10.1039/C3SC52535J  1
2014 Coelho PS, Arnold FH, Lewis JC. Synthetic Biology Approaches for Organic Synthesis Comprehensive Organic Synthesis: Second Edition. 9: 390-420. DOI: 10.1016/B978-0-08-097742-3.00931-9  1
2013 Trudeau DL, Smith MA, Arnold FH. Innovation by homologous recombination. Current Opinion in Chemical Biology. 17: 902-9. PMID 24182747 DOI: 10.1016/j.cbpa.2013.10.007  1
2013 Zhang WB, Sun F, Tirrell DA, Arnold FH. Controlling macromolecular topology with genetically encoded SpyTag-SpyCatcher chemistry. Journal of the American Chemical Society. 135: 13988-97. PMID 23964715 DOI: 10.1021/ja4076452  1
2013 McIntosh JA, Coelho PS, Farwell CC, Wang ZJ, Lewis JC, Brown TR, Arnold FH. Enantioselective intramolecular C-H amination catalyzed by engineered cytochrome P450 enzymes in vitro and in vivo. Angewandte Chemie (International Ed. in English). 52: 9309-12. PMID 23893546 DOI: 10.1002/anie.201304401  1
2013 Coelho PS, Wang ZJ, Ener ME, Baril SA, Kannan A, Arnold FH, Brustad EM. A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo. Nature Chemical Biology. 9: 485-7. PMID 23792734 DOI: 10.1038/nchembio.1278  1
2013 Brinkmann-Chen S, Flock T, Cahn JK, Snow CD, Brustad EM, McIntosh JA, Meinhold P, Zhang L, Arnold FH. General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH. Proceedings of the National Academy of Sciences of the United States of America. 110: 10946-51. PMID 23776225 DOI: 10.1073/pnas.1306073110  1
2013 Smith MA, Bedbrook CN, Wu T, Arnold FH. Hypocrea jecorina cellobiohydrolase I stabilizing mutations identified using noncontiguous recombination. Acs Synthetic Biology. 2: 690-6. PMID 23688124 DOI: 10.1021/sb400010m  1
2013 Wu I, Heel T, Arnold FH. Role of cysteine residues in thermal inactivation of fungal Cel6A cellobiohydrolases. Biochimica Et Biophysica Acta. 1834: 1539-44. PMID 23676789 DOI: 10.1016/j.bbapap.2013.05.003  1
2013 Lauchli R, Rabe KS, Kalbarczyk KZ, Tata A, Heel T, Kitto RZ, Arnold FH. High-throughput screening for terpene-synthase-cyclization activity and directed evolution of a terpene synthase. Angewandte Chemie (International Ed. in English). 52: 5571-4. PMID 23532864 DOI: 10.1002/anie.201301362  1
2013 Romero PA, Shapiro MG, Arnold FH, Jasanoff A. Directed evolution of protein-based neurotransmitter sensors for MRI. Methods in Molecular Biology (Clifton, N.J.). 995: 193-205. PMID 23494381 DOI: 10.1007/978-1-62703-345-9_14  1
2013 Heinzelman P, Romero PA, Arnold FH. Efficient sampling of SCHEMA chimera families to identify useful sequence elements. Methods in Enzymology. 523: 351-68. PMID 23422438 DOI: 10.1016/B978-0-12-394292-0.00016-3  1
2013 Wu I, Arnold FH. Engineered thermostable fungal Cel6A and Cel7A cellobiohydrolases hydrolyze cellulose efficiently at elevated temperatures. Biotechnology and Bioengineering. 110: 1874-83. PMID 23404363 DOI: 10.1002/bit.24864  1
2013 Romero PA, Krause A, Arnold FH. Navigating the protein fitness landscape with Gaussian processes. Proceedings of the National Academy of Sciences of the United States of America. 110: E193-201. PMID 23277561 DOI: 10.1073/pnas.1215251110  1
2013 Coelho PS, Brustad EM, Kannan A, Arnold FH. Olefin cyclopropanation via carbene transfer catalyzed by engineered cytochrome P450 enzymes. Science (New York, N.Y.). 339: 307-10. PMID 23258409 DOI: 10.1126/science.1231434  1
2013 Smith MA, Romero PA, Wu T, Brustad EM, Arnold FH. Chimeragenesis of distantly-related proteins by noncontiguous recombination. Protein Science : a Publication of the Protein Society. 22: 231-8. PMID 23225662 DOI: 10.1002/pro.2202  1
2012 Smith MA, Rentmeister A, Snow CD, Wu T, Farrow MF, Mingardon F, Arnold FH. A diverse set of family 48 bacterial glycoside hydrolase cellulases created by structure-guided recombination. The Febs Journal. 279: 4453-65. PMID 23075376 DOI: 10.1111/febs.12032  1
2012 Romero PA, Arnold FH. Random field model reveals structure of the protein recombinational landscape. Plos Computational Biology. 8: e1002713. PMID 23055915 DOI: 10.1371/journal.pcbi.1002713  1
2012 Liu X, Bastian S, Snow CD, Brustad EM, Saleski TE, Xu JH, Meinhold P, Arnold FH. Structure-guided engineering of Lactococcus lactis alcohol dehydrogenase LlAdhA for improved conversion of isobutyraldehyde to isobutanol. Journal of Biotechnology. 164: 188-95. PMID 22974724 DOI: 10.1016/j.jbiotec.2012.08.008  1
2012 Komor RS, Romero PA, Xie CB, Arnold FH. Highly thermostable fungal cellobiohydrolase I (Cel7A) engineered using predictive methods. Protein Engineering, Design & Selection : Peds. 25: 827-33. PMID 22961332 DOI: 10.1093/protein/gzs058  1
2012 Romero PA, Stone E, Lamb C, Chantranupong L, Krause A, Miklos AE, Hughes RA, Fechtel B, Ellington AD, Arnold FH, Georgiou G. SCHEMA-designed variants of human Arginase I and II reveal sequence elements important to stability and catalysis. Acs Synthetic Biology. 1: 221-8. PMID 22737599 DOI: 10.1021/sb300014t  1
2012 Brustad EM, Lelyveld VS, Snow CD, Crook N, Jung ST, Martinez FM, Scholl TJ, Jasanoff A, Arnold FH. Structure-guided directed evolution of highly selective p450-based magnetic resonance imaging sensors for dopamine and serotonin. Journal of Molecular Biology. 422: 245-62. PMID 22659321 DOI: 10.1016/j.jmb.2012.05.029  1
2012 Chen MM, Snow CD, Vizcarra CL, Mayo SL, Arnold FH. Comparison of random mutagenesis and semi-rational designed libraries for improved cytochrome P450 BM3-catalyzed hydroxylation of small alkanes. Protein Engineering, Design & Selection : Peds. 25: 171-8. PMID 22334757 DOI: 10.1093/protein/gzs004  1
2012 Bastian S, Arnold FH. Reversal of NAD(P)H cofactor dependence by protein engineering. Methods in Molecular Biology (Clifton, N.J.). 834: 17-31. PMID 22144350 DOI: 10.1007/978-1-61779-483-4_2  1
2012 Chen MM, Coelho PS, Arnold FH. Utilizing terminal oxidants to achieve P450-catalyzed oxidation of methane Advanced Synthesis and Catalysis. 354: 964-968. DOI: 10.1002/adsc.201100833  1
2011 Lee TM, Farrow MF, Arnold FH, Mayo SL. A structural study of Hypocrea jecorina Cel5A. Protein Science : a Publication of the Protein Society. 20: 1935-40. PMID 21898652 DOI: 10.1002/pro.730  1
2011 Farrow MF, Arnold FH. High throughput screening of fungal endoglucanase activity in Escherichia coli. Journal of Visualized Experiments : Jove. PMID 21860379 DOI: 10.3791/2942  1
2011 Bastian S, Liu X, Meyerowitz JT, Snow CD, Chen MM, Arnold FH. Engineered ketol-acid reductoisomerase and alcohol dehydrogenase enable anaerobic 2-methylpropan-1-ol production at theoretical yield in Escherichia coli. Metabolic Engineering. 13: 345-52. PMID 21515217 DOI: 10.1016/j.ymben.2011.02.004  1
2011 Jung ST, Lauchli R, Arnold FH. Cytochrome P450: taming a wild type enzyme. Current Opinion in Biotechnology. 22: 809-17. PMID 21411308 DOI: 10.1016/j.copbio.2011.02.008  1
2011 Brenner K, Arnold FH. Self-organization, layered structure, and aggregation enhance persistence of a synthetic biofilm consortium. Plos One. 6: e16791. PMID 21347422 DOI: 10.1371/journal.pone.0016791  1
2011 Fasan R, Crook NC, Peters MW, Meinhold P, Buelter T, Landwehr M, Cirino PC, Arnold FH. Improved product-per-glucose yields in P450-dependent propane biotransformations using engineered Escherichia coli. Biotechnology and Bioengineering. 108: 500-10. PMID 21246504 DOI: 10.1002/bit.22984  1
2011 Brustad EM, Arnold FH. Optimizing non-natural protein function with directed evolution. Current Opinion in Chemical Biology. 15: 201-10. PMID 21185770 DOI: 10.1016/j.cbpa.2010.11.020  1
2011 Lelyveld VS, Brustad E, Arnold FH, Jasanoff A. Metal-substituted protein MRI contrast agents engineered for enhanced relaxivity and ligand sensitivity. Journal of the American Chemical Society. 133: 649-51. PMID 21171606 DOI: 10.1021/ja107936d  1
2011 Mingardon F, Bagert JD, Maisonnier C, Trudeau DL, Arnold FH. Comparison of family 9 cellulases from mesophilic and thermophilic bacteria. Applied and Environmental Microbiology. 77: 1436-42. PMID 21169454 DOI: 10.1128/AEM.01802-10  1
2011 Lewis JC, Coelho PS, Arnold FH. Enzymatic functionalization of carbon-hydrogen bonds. Chemical Society Reviews. 40: 2003-21. PMID 21079862 DOI: 10.1039/c0cs00067a  1
2011 Rentmeister A, Brown TR, Snow CD, Carbone MN, Arnold FH. Engineered Bacterial Mimics of Human Drug Metabolizing Enzyme CYP2C9 Chemcatchem. 3: 1065-1071. DOI: 10.1002/cctc.201000452  1
2011 Saab-Rincon G, Li Y, Meyer M, Carbone M, Landwehr M, Arnold FH. Protein Engineering by Structure-Guided SCHEMA Recombination Protein Engineering Handbook, Volume 1 & Volume 2. 2: 481-492. DOI: 10.1002/9783527634026.ch20  1
2011 Farrow MF, Lee TM, Snow CD, Romero PP, Arnold FH. SCHEMA recombination reveals structural characteristics of active variants of Hypocrea jecorina Cel5a Acs National Meeting Book of Abstracts 1
2011 Arnold FH. The library of Maynard-Smith: My search for meaning in the protein universe Microbe. 6: 316-318.  1
2010 Lewis JC, Mantovani SM, Fu Y, Snow CD, Komor RS, Wong CH, Arnold FH. Combinatorial alanine substitution enables rapid optimization of cytochrome P450BM3 for selective hydroxylation of large substrates. Chembiochem : a European Journal of Chemical Biology. 11: 2502-5. PMID 21108271 DOI: 10.1002/cbic.201000565  1
2010 Acar M, Pando BF, Arnold FH, Elowitz MB, van Oudenaarden A. A general mechanism for network-dosage compensation in gene circuits. Science (New York, N.Y.). 329: 1656-60. PMID 20929850 DOI: 10.1126/science.1190544  1
2010 Heinzelman P, Komor R, Kanaan A, Romero P, Yu X, Mohler S, Snow C, Arnold F. Efficient screening of fungal cellobiohydrolase class i enzymes for thermostabilizing sequence blocks by SCHEMA structure-guided recombination Protein Engineering, Design and Selection. 23: 871-880. PMID 20847102 DOI: 10.1093/protein/gzq063  1
2010 Farrow MF, Arnold FH. Combinatorial recombination of gene fragments to construct a library of chimeras. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 26.2. PMID 20814931 DOI: 10.1002/0471140864.ps2602s61  1
2010 Jäckel C, Bloom JD, Kast P, Arnold FH, Hilvert D. Consensus protein design without phylogenetic bias. Journal of Molecular Biology. 399: 541-6. PMID 20433850 DOI: 10.1016/j.jmb.2010.04.039  1
2010 Shapiro MG, Westmeyer GG, Romero PA, Szablowski JO, Küster B, Shah A, Otey CR, Langer R, Arnold FH, Jasanoff A. Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine. Nature Biotechnology. 28: 264-70. PMID 20190737 DOI: 10.1038/nbt.1609  1
2010 Heinzelman P, Komor R, Kanaan A, Romero P, Yu X, Mohler S, Snow CD, Arnold FH. Efficient screening of natural fungal cellobiohydrolase genes for desirable mutations by SCHEMA structure-guided recombination 10aiche - 2010 Aiche Annual Meeting, Conference Proceedings 0.68
2009 Arnold FH. How proteins adapt: lessons from directed evolution. Cold Spring Harbor Symposia On Quantitative Biology. 74: 41-6. PMID 20413708 DOI: 10.1101/sqb.2009.74.046  1
2009 Arkin A, Berry D, Church G, Arnold F, Boldt J, Müller O, Ellington AD, Endy D, Fussenegger M, Gold ER, Greenwood J, Lee SY, Lim W, Minshull J, Murray TH, et al. What's in a name? Nature Biotechnology. 27: 1071-1073. PMID 20010573 DOI: 10.1038/nbt1209-1071  1
2009 Romero PA, Arnold FH. Exploring protein fitness landscapes by directed evolution. Nature Reviews. Molecular Cell Biology. 10: 866-76. PMID 19935669 DOI: 10.1038/nrm2805  1
2009 Lewis JC, Bastian S, Bennett CS, Fu Y, Mitsuda Y, Chen MM, Greenberg WA, Wong CH, Arnold FH. Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450BM3 demethylases. Proceedings of the National Academy of Sciences of the United States of America. 106: 16550-5. PMID 19805336 DOI: 10.1073/pnas.0908954106  1
2009 Sawayama AM, Chen MM, Kulanthaivel P, Kuo MS, Hemmerle H, Arnold FH. A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 11723-9. PMID 19774562 DOI: 10.1002/chem.200900643  1
2009 Dougherty MJ, Arnold FH. Directed evolution: new parts and optimized function. Current Opinion in Biotechnology. 20: 486-91. PMID 19720520 DOI: 10.1016/j.copbio.2009.08.005  1
2009 Heinzelman P, Snow CD, Smith MA, Yu X, Kannan A, Boulware K, Villalobos A, Govindarajan S, Minshull J, Arnold FH. SCHEMA recombination of a fungal cellulase uncovers a single mutation that contributes markedly to stability. The Journal of Biological Chemistry. 284: 26229-33. PMID 19625252 DOI: 10.1074/jbc.C109.034058  1
2009 Bloom JD, Arnold FH. In the light of directed evolution: pathways of adaptive protein evolution. Proceedings of the National Academy of Sciences of the United States of America. 106: 9995-10000. PMID 19528653 DOI: 10.1073/pnas.0901522106  1
2009 Heinzelman P, Snow CD, Wu I, Nguyen C, Villalobos A, Govindarajan S, Minshull J, Arnold FH. A family of thermostable fungal cellulases created by structure-guided recombination. Proceedings of the National Academy of Sciences of the United States of America. 106: 5610-5. PMID 19307582 DOI: 10.1073/pnas.0901417106  1
2009 Tracewell CA, Arnold FH. Directed enzyme evolution: climbing fitness peaks one amino acid at a time. Current Opinion in Chemical Biology. 13: 3-9. PMID 19249235 DOI: 10.1016/j.cbpa.2009.01.017  1
2009 Rentmeister A, Arnold FH, Fasan R. Chemo-enzymatic fluorination of unactivated organic compounds. Nature Chemical Biology. 5: 26-8. PMID 19011638 DOI: 10.1038/nchembio.128  1
2009 Koch DJ, Chen MM, van Beilen JB, Arnold FH. In vivo evolution of butane oxidation by terminal alkane hydroxylases AlkB and CYP153A6. Applied and Environmental Microbiology. 75: 337-44. PMID 19011057 DOI: 10.1128/AEM.01758-08  1
2009 Arnold FH, Lewis JC. Catalysts on demand: Selective oxidations by laboratory-evolved cytochrome P450 BM3 Chimia. 63: 309-312. DOI: 10.2533/chimia.2009.309  1
2009 Brenner K, You L, Arnold FH. Response to Goldman and Brown: Making sense of microbial consortia using ecology and evolution Trends in Biotechnology. 27: 4. DOI: 10.1016/j.tibtech.2008.10.004  1
2008 Brenner K, You L, Arnold FH. Engineering microbial consortia: a new frontier in synthetic biology. Trends in Biotechnology. 26: 483-9. PMID 18675483 DOI: 10.1016/j.tibtech.2008.05.004  1
2008 Fasan R, Meharenna YT, Snow CD, Poulos TL, Arnold FH. Evolutionary history of a specialized p450 propane monooxygenase. Journal of Molecular Biology. 383: 1069-80. PMID 18619466 DOI: 10.1016/j.jmb.2008.06.060  1
2008 Balagaddé FK, Song H, Ozaki J, Collins CH, Barnet M, Arnold FH, Quake SR, You L. A synthetic Escherichia coli predator-prey ecosystem. Molecular Systems Biology. 4: 187. PMID 18414488 DOI: 10.1038/msb.2008.24  1
2008 Haseltine EL, Arnold FH. Implications of rewiring bacterial quorum sensing. Applied and Environmental Microbiology. 74: 437-45. PMID 18039819 DOI: 10.1128/AEM.01688-07  1
2008 May O, Voigt CA, Arnold FH. Enzyme engineering by directed evolution Enzyme Catalysis in Organic Synthesis: Second Edition. 95-138. DOI: 10.1002/9783527618262.ch4  1
2007 Brenner K, Karig DK, Weiss R, Arnold FH. Engineered bidirectional communication mediates a consensus in a microbial biofilm consortium. Proceedings of the National Academy of Sciences of the United States of America. 104: 17300-4. PMID 17959781 DOI: 10.1073/pnas.0704256104  1
2007 Fasan R, Chen MM, Crook NC, Arnold FH. Engineered alkane-hydroxylating cytochrome P450(BM3) exhibiting nativelike catalytic properties. Angewandte Chemie (International Ed. in English). 46: 8414-8. PMID 17886313 DOI: 10.1002/anie.200702616  1
2007 Carbone MN, Arnold FH. Engineering by homologous recombination: exploring sequence and function within a conserved fold. Current Opinion in Structural Biology. 17: 454-9. PMID 17884462 DOI: 10.1016/j.sbi.2007.08.005  1
2007 Li Y, Drummond DA, Sawayama AM, Snow CD, Bloom JD, Arnold FH. A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments. Nature Biotechnology. 25: 1051-6. PMID 17721510 DOI: 10.1038/nbt1333  1
2007 Hawkins AC, Arnold FH, Stuermer R, Hauer B, Leadbetter JR. Directed evolution of Vibrio fischeri LuxR for improved response to butanoyl-homoserine lactone. Applied and Environmental Microbiology. 73: 5775-81. PMID 17675429 DOI: 10.1128/AEM.00060-07  1
2007 Bloom JD, Lu Z, Chen D, Raval A, Venturelli OS, Arnold FH. Evolution favors protein mutational robustness in sufficiently large populations. Bmc Biology. 5: 29. PMID 17640347 DOI: 10.1186/1741-7007-5-29  1
2007 Bloom JD, Romero PA, Lu Z, Arnold FH. Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution. Biology Direct. 2: 17. PMID 17598905 DOI: 10.1186/1745-6150-2-17  1
2007 Landwehr M, Carbone M, Otey CR, Li Y, Arnold FH. Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s. Chemistry & Biology. 14: 269-78. PMID 17379142 DOI: 10.1016/j.chembiol.2007.01.009  1
2007 Bloom JD, Arnold FH, Wilke CO. Breaking proteins with mutations: threads and thresholds in evolution. Molecular Systems Biology. 3: 76. PMID 17262035 DOI: 10.1038/msb4100119  1
2007 Haseltine EL, Arnold FH. Synthetic gene circuits: design with directed evolution. Annual Review of Biophysics and Biomolecular Structure. 36: 1-19. PMID 17243895 DOI: 10.1146/annurev.biophys.36.040306.132600  1
2007 Fasan R, Arnold FH. Laboratory evolution of P450 alkane monooxygenases Acs National Meeting Book of Abstracts 1
2006 Meyer MM, Hiraga K, Arnold FH. Combinatorial recombination of gene fragments to construct a library of chimeras. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 26.2. PMID 18429308 DOI: 10.1002/0471140864.ps2602s44  1
2006 Meyer MM, Hochrein L, Arnold FH. Structure-guided SCHEMA recombination of distantly related beta-lactamases. Protein Engineering, Design & Selection : Peds. 19: 563-70. PMID 17090554 DOI: 10.1093/protein/gzl045  1
2006 Bloom JD, Drummond DA, Arnold FH, Wilke CO. Structural determinants of the rate of protein evolution in yeast. Molecular Biology and Evolution. 23: 1751-61. PMID 16782762 DOI: 10.1093/molbev/msl040  1
2006 Collins CH, Leadbetter JR, Arnold FH. Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR. Nature Biotechnology. 24: 708-12. PMID 16715074 DOI: 10.1038/nbt1209  1
2006 Landwehr M, Hochrein L, Otey CR, Kasrayan A, Bäckvall JE, Arnold FH. Enantioselective alpha-hydroxylation of 2-arylacetic acid derivatives and buspirone catalyzed by engineered cytochrome P450 BM-3. Journal of the American Chemical Society. 128: 6058-9. PMID 16669674 DOI: 10.1021/ja061261x  1
2006 Otey CR, Landwehr M, Endelman JB, Hiraga K, Bloom JD, Arnold FH. Structure-guided recombination creates an artificial family of cytochromes P450. Plos Biology. 4: e112. PMID 16594730 DOI: 10.1371/journal.pbio.0040112  1
2006 Bloom JD, Labthavikul ST, Otey CR, Arnold FH. Protein stability promotes evolvability. Proceedings of the National Academy of Sciences of the United States of America. 103: 5869-74. PMID 16581913 DOI: 10.1073/pnas.0510098103  1
2006 Arnold FH. Fancy footwork in the sequence space shuffle. Nature Biotechnology. 24: 328-30. PMID 16525408 DOI: 10.1038/nbt0306-328  1
2006 Tobias AV, Arnold FH. Biosynthesis of novel carotenoid families based on unnatural carbon backbones: a model for diversification of natural product pathways. Biochimica Et Biophysica Acta. 1761: 235-46. PMID 16478677 DOI: 10.1016/j.bbalip.2006.01.003  1
2006 Kubo T, Peters MW, Meinhold P, Arnold FH. Enantioselective epoxidation of terminal alkenes to (R)- and (S)-epoxides by engineered cytochromes P450 BM-3. Chemistry (Weinheim An Der Bergstrasse, Germany). 12: 1216-20. PMID 16240317 DOI: 10.1002/chem.200500584  1
2006 Otey CR, Bandara G, Lalonde J, Takahashi K, Arnold FH. Preparation of human metabolites of propranolol using laboratory-evolved bacterial cytochromes P450. Biotechnology and Bioengineering. 93: 494-9. PMID 16224788 DOI: 10.1002/bit.20744  1
2006 Meinhold P, Peters MW, Hartwick A, Hernandez AR, Arnold FH. Engineering cytochrome P450 BM3 for terminal alkane hydroxylation Advanced Synthesis and Catalysis. 348: 763-772. DOI: 10.1002/adsc.200505465  1
2006 Arnold FH. Directed evolution improves oxidases Industrial Bioprocessing. 28: 7.  1
2005 Drummond DA, Bloom JD, Adami C, Wilke CO, Arnold FH. Why highly expressed proteins evolve slowly. Proceedings of the National Academy of Sciences of the United States of America. 102: 14338-43. PMID 16176987 DOI: 10.1073/pnas.0504070102  1
2005 Meinhold P, Peters MW, Chen MM, Takahashi K, Arnold FH. Direct conversion of ethane to ethanol by engineered cytochrome P450 BM3. Chembiochem : a European Journal of Chemical Biology. 6: 1765-8. PMID 16080215 DOI: 10.1002/cbic.200500261  1
2005 Bloom JD, Meyer MM, Meinhold P, Otey CR, MacMillan D, Arnold FH. Evolving strategies for enzyme engineering. Current Opinion in Structural Biology. 15: 447-52. PMID 16006119 DOI: 10.1016/j.sbi.2005.06.004  1
2005 Balagaddé FK, You L, Hansen CL, Arnold FH, Quake SR. Long-term monitoring of bacteria undergoing programmed population control in a microchemostat. Science (New York, N.Y.). 309: 137-40. PMID 15994559 DOI: 10.1126/science.1109173  1
2005 Drummond DA, Iverson BL, Georgiou G, Arnold FH. Why high-error-rate random mutagenesis libraries are enriched in functional and improved proteins. Journal of Molecular Biology. 350: 806-16. PMID 15939434 DOI: 10.1016/j.jmb.2005.05.023  1
2005 Udit AK, Hindoyan N, Hill MG, Arnold FH, Gray HB. Protein-surfactant film voltammetry of wild-type and mutant cytochrome P450 BM3. Inorganic Chemistry. 44: 4109-11. PMID 15934729 DOI: 10.1021/ic0483747  1
2005 Münzer DF, Meinhold P, Peters MW, Feichtenhofer S, Griengl H, Arnold FH, Glieder A, de Raadt A. Stereoselective hydroxylation of an achiral cyclopentanecarboxylic acid derivative using engineered P450s BM-3. Chemical Communications (Cambridge, England). 2597-9. PMID 15900339 DOI: 10.1039/b501527h  1
2005 Basu S, Gerchman Y, Collins CH, Arnold FH, Weiss R. A synthetic multicellular system for programmed pattern formation. Nature. 434: 1130-4. PMID 15858574 DOI: 10.1038/nature03461  1
2005 Drummond DA, Silberg JJ, Meyer MM, Wilke CO, Arnold FH. On the conservative nature of intragenic recombination. Proceedings of the National Academy of Sciences of the United States of America. 102: 5380-5. PMID 15809422 DOI: 10.1073/pnas.0500729102  0.96
2005 Umeno D, Tobias AV, Arnold FH. Diversifying carotenoid biosynthetic pathways by directed evolution. Microbiology and Molecular Biology Reviews : Mmbr. 69: 51-78. PMID 15755953 DOI: 10.1128/MMBR.69.1.51-78.2005  1
2005 Collins CH, Arnold FH, Leadbetter JR. Directed evolution of Vibrio fischeri LuxR for increased sensitivity to a broad spectrum of acyl-homoserine lactones. Molecular Microbiology. 55: 712-23. PMID 15660998 DOI: 10.1111/j.1365-2958.2004.04437.x  1
2005 Bloom JD, Silberg JJ, Wilke CO, Drummond DA, Adami C, Arnold FH. Thermodynamic prediction of protein neutrality. Proceedings of the National Academy of Sciences of the United States of America. 102: 606-11. PMID 15644440 DOI: 10.1073/pnas.0406744102  0.96
2005 Yokobayashi Y, Arnold FH. A dual selection module for directed evolution of genetic circuits Natural Computing. 4: 245-254. DOI: 10.1007/s11047-004-7442-x  1
2005 Ozaki J, Barnet M, Collins CH, Arnold FH, You L. A synthetic E.Coli predator-prey system Aiche Annual Meeting, Conference Proceedings. 11590.  1
2004 Malliaros J, Quinn C, Arnold FH, Pearse MJ, Drane DP, Stewart TJ, Macfarlan RI. Association of antigens to ISCOMATRIX adjuvant using metal chelation leads to improved CTL responses. Vaccine. 22: 3968-75. PMID 15364446 DOI: 10.1016/j.vaccine.2004.03.054  1
2004 Udit AK, Arnold FH, Gray HB. Cobaltocene-mediated catalytic monooxygenation using holo and heme domain cytochrome P450 BM3. Journal of Inorganic Biochemistry. 98: 1547-50. PMID 15337607 DOI: 10.1016/j.jinorgbio.2004.06.007  1
2004 Endelman JB, Silberg JJ, Wang ZG, Arnold FH. Site-directed protein recombination as a shortest-path problem. Protein Engineering, Design & Selection : Peds. 17: 589-94. PMID 15331774 DOI: 10.1093/protein/gzh067  0.96
2004 Udit AK, Hill MG, Bittner VG, Arnold FH, Gray HB. Reduction of dioxygen catalyzed by pyrene-wired heme domain cytochrome P450 BM3 electrodes. Journal of the American Chemical Society. 126: 10218-9. PMID 15315414 DOI: 10.1021/ja0466560  1
2004 Silberg JJ, Endelman JB, Arnold FH. SCHEMA-guided protein recombination. Methods in Enzymology. 388: 35-42. PMID 15289059 DOI: 10.1016/S0076-6879(04)88004-2  0.96
2004 Otey CR, Silberg JJ, Voigt CA, Endelman JB, Bandara G, Arnold FH. Functional evolution and structural conservation in chimeric cytochromes p450: calibrating a structure-guided approach. Chemistry & Biology. 11: 309-18. PMID 15123260 DOI: 10.1016/j.chembiol.2004.02.018  0.96
2004 Bloom JD, Wilke CO, Arnold FH, Adami C. Stability and the evolvability of function in a model protein. Biophysical Journal. 86: 2758-64. PMID 15111394 DOI: 10.1016/S0006-3495(04)74329-5  1
2004 You L, Cox RS, Weiss R, Arnold FH. Programmed population control by cell-cell communication and regulated killing. Nature. 428: 868-71. PMID 15064770 DOI: 10.1038/nature02491  1
2004 Alcalde M, Farinas ET, Arnold FH. Colorimetric high-throughput assay for alkene epoxidation catalyzed by cytochrome P450 BM-3 variant 139-3. Journal of Biomolecular Screening. 9: 141-6. PMID 15006137 DOI: 10.1177/1087057103261913  1
2004 Umeno D, Arnold FH. Evolution of a pathway to novel long-chain carotenoids. Journal of Bacteriology. 186: 1531-6. PMID 14973014 DOI: 10.1128/JB.186.5.1531-1536.2004  1
2004 Wong TS, Arnold FH, Schwaneberg U. Laboratory evolution of cytochrome p450 BM-3 monooxygenase for organic cosolvents. Biotechnology and Bioengineering. 85: 351-8. PMID 14748091 DOI: 10.1002/bit.10896  1
2003 Collins CH, Yokobayashi Y, Umeno D, Arnold FH. Engineering proteins that bind, move, make and break DNA. Current Opinion in Biotechnology. 14: 665. PMID 14662399  1
2003 Peters MW, Meinhold P, Glieder A, Arnold FH. Regio- and enantioselective alkane hydroxylation with engineered cytochromes P450 BM-3. Journal of the American Chemical Society. 125: 13442-50. PMID 14583039 DOI: 10.1021/ja0303790  1
2003 Salazar O, Cirino PC, Arnold FH. Thermostabilization of a cytochrome p450 peroxygenase. Chembiochem : a European Journal of Chemical Biology. 4: 891-3. PMID 12964165 DOI: 10.1002/cbic.200300660  1
2003 Collins CH, Yokobayashi Y, Umeno D, Arnold FH. Engineering proteins that bind, move, make and break DNA. Current Opinion in Biotechnology. 14: 371-8. PMID 12943845 DOI: 10.1016/S0958-1669(03)00091-0  1
2003 Umeno D, Hiraga K, Arnold FH. Method to protect a targeted amino acid residue during random mutagenesis. Nucleic Acids Research. 31: e91. PMID 12907743  0.64
2003 Cirino PC, Tang Y, Takahashi K, Tirrell DA, Arnold FH. Global incorporation of norleucine in place of methionine in cytochrome P450 BM-3 heme domain increases peroxygenase activity. Biotechnology and Bioengineering. 83: 729-34. PMID 12889037 DOI: 10.1002/bit.10718  1
2003 Cirino PC, Arnold FH. A self-sufficient peroxide-driven hydroxylation biocatalyst. Angewandte Chemie (International Ed. in English). 42: 3299-301. PMID 12876749 DOI: 10.1002/anie.200351434  1
2003 Meyer MM, Silberg JJ, Voigt CA, Endelman JB, Mayo SL, Wang ZG, Arnold FH. Library analysis of SCHEMA-guided protein recombination. Protein Science : a Publication of the Protein Society. 12: 1686-93. PMID 12876318 DOI: 10.1110/ps.0306603  0.96
2003 Hiraga K, Arnold FH. General method for sequence-independent site-directed chimeragenesis. Journal of Molecular Biology. 330: 287-96. PMID 12823968 DOI: 10.1016/S0022-2836(03)00590-4  1
2003 Umeno D, Arnold FH. A C35 carotenoid biosynthetic pathway. Applied and Environmental Microbiology. 69: 3573-9. PMID 12788765  1
2003 Wintrode PL, Zhang D, Vaidehi N, Arnold FH, Goddard WA. Protein dynamics in a family of laboratory evolved thermophilic enzymes. Journal of Molecular Biology. 327: 745-57. PMID 12634066 DOI: 10.1016/S0022-2836(03)00147-5  1
2003 Bulter T, Alcalde M, Sieber V, Meinhold P, Schlachtbauer C, Arnold FH. Functional expression of a fungal laccase in Saccharomyces cerevisiae by directed evolution. Applied and Environmental Microbiology. 69: 987-95. PMID 12571021 DOI: 10.1128/AEM.69.2.987-995.2003  1
2003 Arnold FH, Glieder A. Chemistry and biotechnology: A productive union meets new challenges Current Opinion in Biotechnology. 14: 567-569. DOI: 10.1016/j.copbio.2003.10.005  1
2002 Alcalde M, Bulter T, Arnold FH. Colorimetric assays for biodegradation of polycyclic aromatic hydrocarbons by fungal laccases. Journal of Biomolecular Screening. 7: 547-53. PMID 14599353 DOI: 10.1177/1087057102238629  1
2002 Yokobayashi Y, Weiss R, Arnold FH. Directed evolution of a genetic circuit. Proceedings of the National Academy of Sciences of the United States of America. 99: 16587-91. PMID 12451174 DOI: 10.1073/pnas.252535999  1
2002 Umeno D, Tobias AV, Arnold FH. Evolution of the C30 carotenoid synthase CrtM for function in a C40 pathway. Journal of Bacteriology. 184: 6690-9. PMID 12426357 DOI: 10.1128/JB.184.23.6690-6699.2002  1
2002 Glieder A, Farinas ET, Arnold FH. Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase. Nature Biotechnology. 20: 1135-9. PMID 12368811 DOI: 10.1038/nbt744  1
2002 Sun L, Bulter T, Alcalde M, Petrounia IP, Arnold FH. Modification of galactose oxidase to introduce glucose 6-oxidase activity. Chembiochem : a European Journal of Chemical Biology. 3: 781-3. PMID 12203977 DOI: 10.1002/1439-7633(20020802)3:8<781::AID-CBIC781>3.0.CO;2-8  1
2002 Fu AY, Chou HP, Spence C, Arnold FH, Quake SR. An integrated microfabricated cell sorter. Analytical Chemistry. 74: 2451-7. PMID 12069222 DOI: 10.1021/ac0255330  1
2002 Voigt CA, Martinez C, Wang ZG, Mayo SL, Arnold FH. Protein building blocks preserved by recombination. Nature Structural Biology. 9: 553-8. PMID 12042875 DOI: 10.1038/nsb805  1
2002 Cirino PC, Arnold FH. Protein engineering of oxygenases for biocatalysis. Current Opinion in Chemical Biology. 6: 130-5. PMID 12038995 DOI: 10.1016/S1367-5931(02)00305-8  1
2002 Mayer KM, Arnold FH. A colorimetric assay to quantify dehydrogenase activity in crude cell lysates. Journal of Biomolecular Screening. 7: 135-40. PMID 12006112 DOI: 10.1089/10870570252906594  1
2002 Joern JM, Meinhold P, Arnold FH. Analysis of shuffled gene libraries. Journal of Molecular Biology. 316: 643-56. PMID 11866523 DOI: 10.1006/jmbi.2001.5349  1
2002 Cirino PC, Arnold FH. Regioselectivity and Activity of Cytochrome P450 BM-3 and Mutant F87A in Reactions Driven by Hydrogen Peroxide Advanced Synthesis and Catalysis. 344: 932-937. DOI: 10.1002/1615-4169(200210)344:9<932::AID-ADSC932>3.0.CO;2-M  1
2001 Farinas ET, Bulter T, Arnold FH. Directed enzyme evolution. Current Opinion in Biotechnology. 12: 545-51. PMID 11849936 DOI: 10.1016/S0958-1669(01)00261-0  1
2001 Voigt CA, Mayo SL, Arnold FH, Wang ZG. Computationally focusing the directed evolution of proteins. Journal of Cellular Biochemistry. Supplement. 58-63. PMID 11842429 DOI: 10.1002/jcb.10066  1
2001 Sun L, Petrounia IP, Yagasaki M, Bandara G, Arnold FH. Expression and stabilization of galactose oxidase in Escherichia coli by directed evolution. Protein Engineering. 14: 699-704. PMID 11707617  1
2001 Joern JM, Sakamoto T, Arisawa A, Arnold FH. A versatile high throughput screen for dioxygenase activity using solid-phase digital imaging. Journal of Biomolecular Screening. 6: 219-23. PMID 11689121 DOI: 10.1089/10870570152488419  1
2001 Schwaneberg U, Otey C, Cirino PC, Farinas E, Arnold FH. Cost-effective whole-cell assay for laboratory evolution of hydroxylases in Escherichia coli. Journal of Biomolecular Screening. 6: 111-7. PMID 11689105 DOI: 10.1089/108705701750160309  1
2001 Wintrode PL, Miyazaki K, Arnold FH. Patterns of adaptation in a laboratory evolved thermophilic enzyme. Biochimica Et Biophysica Acta. 1549: 1-8. PMID 11566363 DOI: 10.1016/S0167-4838(01)00226-6  1
2001 Sakamoto T, Joern JM, Arisawa A, Arnold FH. Laboratory evolution of toluene dioxygenase to accept 4-picoline as a substrate. Applied and Environmental Microbiology. 67: 3882-7. PMID 11525981 DOI: 10.1128/AEM.67.9.3882-3887.2001  1
2001 Morawski B, Quan S, Arnold FH. Development of expression systems for the production of recombinant human serum albumin using the MOX promoter in Hansenula polymorpha DL-1 Biotechnology and Bioengineering. 76: 175-185. PMID 11505387 DOI: 10.1002/bit.1157  1
2001 Sieber V, Martinez CA, Arnold FH. Libraries of hybrid proteins from distantly related sequences. Nature Biotechnology. 19: 456-60. PMID 11329016 DOI: 10.1038/88129  1
2001 Thorsen T, Roberts RW, Arnold FH, Quake SR. Dynamic pattern formation in a vesicle-generating microfluidic device. Physical Review Letters. 86: 4163-6. PMID 11328121  0.6
2001 Voigt CA, Mayo SL, Arnold FH, Wang ZG. Computational method to reduce the search space for directed protein evolution. Proceedings of the National Academy of Sciences of the United States of America. 98: 3778-83. PMID 11274394 DOI: 10.1073/pnas.051614498  1
2001 Arnold FH. Combinatorial and computational challenges for biocatalyst design. Nature. 409: 253-7. PMID 11196654 DOI: 10.1038/35051731  1
2001 Arnold FH, Wintrode PL, Miyazaki K, Gershenson A. How enzymes adapt: lessons from directed evolution. Trends in Biochemical Sciences. 26: 100-6. PMID 11166567 DOI: 10.1016/S0968-0004(00)01755-2  1
2001 Thorsen T, Roberts RW, Arnold FH, Quake SR. Dynamic pattern formation in a vesicle-generating microfluidic device Physical Review Letters. 86: 4163-4166. DOI: 10.1103/PhysRevLett.86.4163  1
2001 Farinas ET, Schwaneberg U, Glieder A, Arnold FH. Directed Evolution of a Cytochrome P450 Monooxygenase for Alkane Oxidation Advanced Synthesis and Catalysis. 343: 601-606.  1
2000 Gershenson A, Arnold FH. Enzyme stabilization by directed evolution. Genetic Engineering. 22: 55-76. PMID 11501381  1
2000 Volkov AA, Shao Z, Arnold FH. Random chimeragenesis by heteroduplex recombination. Methods in Enzymology. 328: 456-63. PMID 11075360  1
2000 Volkov AA, Arnold FH. Methods for in vitro DNA recombination and random chimeragenesis. Methods in Enzymology. 328: 447-56. PMID 11075359  1
2000 Wintrode PL, Arnold FH. Temperature adaptation of enzymes: lessons from laboratory evolution. Advances in Protein Chemistry. 55: 161-225. PMID 11050934  1
2000 Arnold FH. Advances in protein chemistry. Introduction. Advances in Protein Chemistry. 55: ix-xi. PMID 11050930  1
2000 Petrounia IP, Arnold FH. Designed evolution of enzymatic properties Current Opinion in Biotechnology. 11: 325-330. PMID 10975451 DOI: 10.1016/S0958-1669(00)00107-5  1
2000 Lin Z, Thorsen T, Arnold FH. Functional expression of horseradish peroxidase in E. coli By directed evolution Biotechnology Progress. 16: 680. PMID 10933847 DOI: 10.1021/bp990292b  0.6
2000 Wintrode PL, Miyazaki K, Arnold FH. Cold adaptation of a mesophilic subtilisin-like protease by laboratory evolution Journal of Biological Chemistry. 275: 31635-31640. PMID 10906329  1
2000 Schmidt-Dannert C, Umeno D, Arnold FH. Molecular breeding of carotenoid biosynthetic pathways Nature Biotechnology. 18: 750-753. PMID 10888843 DOI: 10.1038/77319  1
2000 Morawski B, Lin Z, Cirino P, Joo H, Bandara G, Arnold FH. Functional expression of horseradish peroxidase in Saccharomyces cerevisiae and Pichia pastoris Protein Engineering. 13: 377-384. PMID 10835112  1
2000 Gershenson A, Schauerte JA, Giver L, Arnold FH. Tryptophan phosphorescence study of enzyme flexibility and unfolding in laboratory-evolved thermostable esterases Biochemistry. 39: 4658-4665. PMID 10769121 DOI: 10.1021/bi992473s  1
2000 Miyazaki K, Wintrode PL, Grayling RA, Rubingh DN, Arnold FH. Directed evolution study of temperature adaptation in a psychrophilic enzyme Journal of Molecular Biology. 297: 1015-1026. PMID 10736234 DOI: 10.1006/jmbi.2000.3612  1
2000 May O, Nguyen PT, Arnold FH. Inverting enantioselectivity by directed evolution of hydantoinase for improved production of L-methionine Nature Biotechnology. 18: 317-320. PMID 10700149 DOI: 10.1038/73773  1
2000 Arnold FH, Zheng W, Michaels AS. A membrane-moderated, conductimetric sensor for the detection and measurement of specific organic solutes in aqueous solutions Journal of Membrane Science. 167: 227-239. DOI: 10.1016/S0376-7388(99)00283-5  1
1999 Miyazaki K, Arnold FH. Exploring nonnatural evolutionary pathways by saturation mutagenesis: Rapid improvement of protein function Journal of Molecular Evolution. 49: 716-720. PMID 10594172  1
1999 Fu AY, Spence C, Scherer A, Arnold FH, Quake SR. A microfabricated fluorescence-activated cell sorter. Nature Biotechnology. 17: 1109-11. PMID 10545919 DOI: 10.1038/15095  1
1999 Arnold FH, Giver L, Gershenson A, Zhao H, Miyazaki K. Directed evolution of mesophilic enzymes into their thermophilic counterparts. Annals of the New York Academy of Sciences. 870: 400-3. PMID 10415508  1
1999 Lin Z, Thorsen T, Arnold FH. Functional expression of horseradish peroxidase in E. coli by directed evolution. Biotechnology Progress. 15: 467-71. PMID 10356264 DOI: 10.1021/bp990037r  1
1999 Zhao H, Arnold FH. Directed evolution converts subtilisin E into a functional equivalent of thermitase. Protein Engineering. 12: 47-53. PMID 10065710  1
1998 Zhao H, Giver L, Shao Z, Affholter JA, Arnold FH. Molecular evolution by staggered extension process (StEP) in vitro recombination. Nature Biotechnology. 16: 258-61. PMID 9528005 DOI: 10.1038/nbt0398-258  1
1998 Shao Z, Zhao H, Giver L, Arnold FH. Random-priming in vitro recombination: an effective tool for directed evolution. Nucleic Acids Research. 26: 681-3. PMID 9421535  1
1997 Zhao H, Arnold FH. Combinatorial protein design: strategies for screening protein libraries. Current Opinion in Structural Biology. 7: 480-5. PMID 9266168  1
1997 Zhao H, Arnold FH. Functional and nonfunctional mutations distinguished by random recombination of homologous genes. Proceedings of the National Academy of Sciences of the United States of America. 94: 7997-8000. PMID 9223302  1
1997 Pack DW, Arnold FH. Langmuir monolayer characterization of metal chelating lipids for protein targeting to membranes Chemistry and Physics of Lipids. 86: 135-152. PMID 9179995 DOI: 10.1016/S0009-3084(97)02662-5  1
1997 Chen G, Guan Z, Chen CT, Fu L, Sundaresan V, Arnold FH. A glucose-sensing polymer. Nature Biotechnology. 15: 354-7. PMID 9094137 DOI: 10.1038/nbt0497-354  1
1997 Zhao H, Arnold FH. Optimization of DNA shuffling for high fidelity recombination. Nucleic Acids Research. 25: 1307-8. PMID 9092645  1
1996 Zhao H, Li Y, Arnold FH. Strategy for the directed evolution of a peptide ligase. Annals of the New York Academy of Sciences. 799: 1-5. PMID 8958065  1
1996 Frey W, Schief WR, Pack DW, Chen CT, Chilkoti A, Stayton P, Vogel V, Arnold FH. Two-dimensional protein crystallization via metal-ion coordination by naturally occurring surface histidines Proceedings of the National Academy of Sciences of the United States of America. 93: 4937-4941. PMID 8643507 DOI: 10.1073/pnas.93.10.4937  1
1993 Chen K, Arnold FH. Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide. Proceedings of the National Academy of Sciences of the United States of America. 90: 5618-22. PMID 8516309  1
1992 Economou C, Chen K, Arnold FH. Random mutagenesis to enhance the activity of subtilisin in organic solvents: Characterization of Q103R subtilisin E. Biotechnology and Bioengineering. 39: 658-62. PMID 18600995 DOI: 10.1002/bit.260390610  1
1992 Martinez P, Van Dam ME, Robinson AC, Chen K, Arnold FH. Stabilization of substilisin E in organic solvents by site-directed mutagenesis. Biotechnology and Bioengineering. 39: 141-7. PMID 18600924 DOI: 10.1002/bit.260390204  1
1991 Chen KQ, Arnold FH. Enzyme engineering for nonaqueous solvents: random mutagenesis to enhance activity of subtilisin E in polar organic media. Bio/Technology (Nature Publishing Company). 9: 1073-7. PMID 1367624  1
1991 Chen KQ, Robinson AC, Van Dam ME, Martinez P, Economou C, Arnold FH. Enzyme engineering for nonaqueous solvents. II. Additive effects of mutations on the stability and activity of subtilisin E in polar organic media. Biotechnology Progress. 7: 125-9. PMID 1367168 DOI: 10.1021/bp00008a007  1
1986 Arnold FH, Blanch HW. Analytical affinity chromatography. II. Rate theory and the measurement of biological binding kinetics. Journal of Chromatography. 355: 13-27. PMID 3700540  1
Show low-probability matches.