Frances H. Arnold - Publications

Affiliations: 
California Institute of Technology, Pasadena, CA 
Area:
Protein engineering, directed protein evolution, structure-guided protein recombination, biocatalysis, biofuels
Website:
http://www.che.caltech.edu/faculty/arnold_f/index.html

312 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Yang J, Li FZ, Arnold FH. Opportunities and Challenges for Machine Learning-Assisted Enzyme Engineering. Acs Central Science. 10: 226-241. PMID 38435522 DOI: 10.1021/acscentsci.3c01275  0.305
2024 Wackelin DJ, Mao R, Sicinski KM, Zhao Y, Das A, Chen K, Arnold FH. Enzymatic Assembly of Diverse Lactone Structures: An Intramolecular C-H Functionalization Strategy. Journal of the American Chemical Society. PMID 38166100 DOI: 10.1021/jacs.3c11722  0.757
2023 Qin ZY, Gao S, Zou Y, Liu Z, Wang JB, Houk KN, Arnold FH. Biocatalytic Construction of Chiral Pyrrolidines and Indolines via Intramolecular C(sp)-H Amination. Acs Central Science. 9: 2333-2338. PMID 38161360 DOI: 10.1021/acscentsci.3c00516  0.378
2023 Mao R, Wackelin DJ, Jamieson CS, Rogge T, Gao S, Das A, Taylor DM, Houk KN, Arnold FH. Enantio- and Diastereoenriched Enzymatic Synthesis of 1,2,3-Polysubstituted Cyclopropanes from (/)-Trisubstituted Enol Acetates. Journal of the American Chemical Society. PMID 37433085 DOI: 10.1021/jacs.3c04870  0.75
2023 Calvó-Tusell C, Liu Z, Chen K, Arnold FH, Garcia-Borràs M. Reversing the Enantioselectivity of Enzymatic Carbene N-H Insertion Through Mechanism-Guided Protein Engineering. Angewandte Chemie (International Ed. in English). e202303879. PMID 37260412 DOI: 10.1002/anie.202303879  0.485
2023 Mao R, Wackelin DJ, Jamieson CS, Rogge T, Gao S, Das A, Taylor DM, Houk KN, Arnold FH. Enantio- and Diastereoenriched Enzymatic Synthesis of 1,2,3-Polysubstituted Cyclopropanes from (Z/E)-Trisubstituted Enol Acetates. Research Square. PMID 37090661 DOI: 10.21203/rs.3.rs-2802333/v1  0.749
2023 Zhang J, Maggiolo AO, Alfonzo E, Mao R, Porter NJ, Abney N, Arnold FH. Chemodivergent C(sp)-H and C(sp)-H Cyanomethylation Using Engineered Carbene Transferases. Nature Catalysis. 6: 152-160. PMID 36875868 DOI: 10.1038/s41929-022-00908-x  0.727
2022 Miller DC, Athavale SV, Arnold FH. Combining chemistry and protein engineering for new-to-nature biocatalysis. Nature Synthesis. 1: 18-23. PMID 35415721 DOI: 10.1038/s44160-021-00008-x  0.302
2021 Liu Z, Qin ZY, Zhu L, Athavale SV, Sengupta A, Jia ZJ, Garcia-Borràs M, Houk KN, Arnold FH. An Enzymatic Platform for Primary Amination of 1-Aryl-2-alkyl Alkynes. Journal of the American Chemical Society. PMID 34941252 DOI: 10.1021/jacs.1c11340  0.351
2021 Liu Z, Calvó-Tusell C, Zhou AZ, Chen K, Garcia-Borràs M, Arnold FH. Dual-function enzyme catalysis for enantioselective carbon-nitrogen bond formation. Nature Chemistry. 13: 1166-1172. PMID 34663919 DOI: 10.1038/s41557-021-00794-z  0.457
2021 Athavale S, Gao S, Liu Z, Mallojjala SC, Hirschi J, Arnold FH. Biocatalytic, Intermolecular C-H Bond Functionalization for the Synthesis of Enantioenriched Amides. Angewandte Chemie (International Ed. in English). PMID 34534409 DOI: 10.1002/anie.202110873  0.343
2021 Watkins-Dulaney EJ, Dunham NP, Straathof S, Turi S, Arnold FH, Buller AR. Asymmetric Alkylation of Ketones Catalyzed by Engineered TrpB. Angewandte Chemie (International Ed. in English). PMID 34269506 DOI: 10.1002/anie.202106938  0.719
2021 Yang Y, Arnold FH. Navigating the Unnatural Reaction Space: Directed Evolution of Heme Proteins for Selective Carbene and Nitrene Transfer. Accounts of Chemical Research. PMID 33491448 DOI: 10.1021/acs.accounts.0c00591  0.399
2020 Liu Z, Arnold FH. New-to-nature chemistry from old protein machinery: carbene and nitrene transferases. Current Opinion in Biotechnology. 69: 43-51. PMID 33370622 DOI: 10.1016/j.copbio.2020.12.005  0.343
2020 Watkins-Dulaney EJ, Straathof S, Arnold FH. Tryptophan Synthase: Biocatalyst Extraordinaire. Chembiochem : a European Journal of Chemical Biology. PMID 32677310 DOI: 10.1002/Cbic.202000379  0.409
2020 Jia ZJ, Gao S, Arnold FH. Enzymatic Primary Amination of Benzylic and Allylic C(sp)-H Bonds. Journal of the American Chemical Society. PMID 32450692 DOI: 10.1021/Jacs.0C03428  0.367
2020 Chen K, Arnold FH. Engineering cytochrome P450s for enantioselective cyclopropenation of internal alkynes. Journal of the American Chemical Society. PMID 32223130 DOI: 10.1021/Jacs.0C01313  0.502
2020 Bähr S, Brinkmann-Chen S, Garcia-Borràs M, Roberts JM, Katsoulis DE, Houk KN, Arnold FH. Selective Enzymatic Oxidation of Silanes to Silanols. Angewandte Chemie (International Ed. in English). PMID 32212229 DOI: 10.1002/Anie.202002861  0.367
2020 Zhou AZ, Chen K, Arnold FH. Enzymatic Lactone-Carbene C–H Insertion to Build Contiguous Chiral Centers Acs Catalysis. 10: 5393-5398. DOI: 10.1021/Acscatal.0C01349  0.48
2019 Romney DK, Sarai NS, Arnold FH. Nitroalkanes as Versatile Nucleophiles for Enzymatic Synthesis of Noncanonical Amino Acids. Acs Catalysis. 9: 8726-8730. PMID 33274115 DOI: 10.1021/Acscatal.9B02089  0.344
2019 Brandenberg OF, Miller DC, Markel U, Chaib AO, Arnold FH. Engineering Chemoselectivity in Hemoprotein-Catalyzed Indole Amidation. Acs Catalysis. 9: 8271-8275. PMID 31938573 DOI: 10.1021/Acscatal.9B02508  0.42
2019 Goldberg NW, Knight AM, Zhang RK, Arnold FH. Nitrene Transfer Catalyzed by a Non-Heme Iron Enzyme and Enhanced by Non-Native Small-Molecule Ligands. Journal of the American Chemical Society. PMID 31790588 DOI: 10.1021/Jacs.9B11608  0.354
2019 Dick M, Sarai NS, Martynowycz MW, Gonen T, Arnold FH. Tailoring Tryptophan Synthase TrpB for Selective Quaternary Carbon Bond Formation. Journal of the American Chemical Society. PMID 31747522 DOI: 10.1021/Jacs.9B09864  0.363
2019 Yang Y, Cho I, Qi X, Liu P, Arnold FH. An enzymatic platform for the asymmetric amination of primary, secondary and tertiary C(sp)-H bonds. Nature Chemistry. PMID 31611634 DOI: 10.1038/S41557-019-0343-5  0.409
2019 Watkins EJ, Almhjell PJ, Arnold FH. Direct enzymatic synthesis of a deep-blue fluorescent noncanonical amino acid from azulene and serine. Chembiochem : a European Journal of Chemical Biology. PMID 31513332 DOI: 10.1002/Cbic.201900497  0.338
2019 Arnold FH. Innovation by Evolution: Bringing New Chemistry to Life (Nobel Lecture). Angewandte Chemie (International Ed. in English). PMID 31433107 DOI: 10.1002/Anie.201907729  0.322
2019 Yang KK, Wu Z, Arnold FH. Machine-learning-guided directed evolution for protein engineering. Nature Methods. PMID 31308553 DOI: 10.1038/S41592-019-0496-6  0.302
2019 Zhang J, Huang X, Zhang RK, Arnold FH. Enantiodivergent α-Amino C-H Fluoroalkylation Catalyzed by Engineered Cytochrome P450s. Journal of the American Chemical Society. PMID 31187993 DOI: 10.1021/Jacs.9B04344  0.412
2019 Cho I, Jia ZJ, Arnold FH. Site-selective enzymatic C‒H amidation for synthesis of diverse lactams. Science (New York, N.Y.). 364: 575-578. PMID 31073063 DOI: 10.1126/Science.Aaw9068  0.391
2019 Brandenberg OF, Chen K, Arnold FH. Directed Evolution of a Cytochrome P450 Carbene Transferase for Selective Functionalization of Cyclic Compounds. Journal of the American Chemical Society. PMID 31070908 DOI: 10.1021/Jacs.9B02931  0.511
2019 Wu Z, Kan SBJ, Lewis RD, Wittmann BJ, Arnold FH. Machine learning-assisted directed protein evolution with combinatorial libraries. Proceedings of the National Academy of Sciences of the United States of America. PMID 30979809 DOI: 10.1073/Pnas.1901979116  0.344
2019 Chen K, Huang X, Zhang SQ, Zhou AZ, Kan SBJ, Hong X, Arnold FH. Engineered Cytochrome -Catalyzed Lactone-Carbene B-H Insertion. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 30: 378-382. PMID 30930550 DOI: 10.1055/S-0037-1611662  0.453
2019 Huang X, Garcia-Borràs M, Miao K, Kan SBJ, Zutshi A, Houk KN, Arnold FH. A Biocatalytic Platform for Synthesis of Chiral Trifluoromethylated Organoborons. Acs Central Science. 5: 270-276. PMID 30834315 DOI: 10.1021/Acscentsci.8B00679  0.35
2019 Cho I, Prier CK, Jia ZJ, Zhang RK, Görbe T, Arnold FH. Enantioselective Aminohydroxylation of Styrenyl Olefins Catalyzed by an Engineered Hemoprotein. Angewandte Chemie (International Ed. in English). PMID 30600873 DOI: 10.1002/Anie.201812968  0.357
2018 Zhang RK, Chen K, Huang X, Wohlschlager L, Renata H, Arnold FH. Enzymatic assembly of carbon-carbon bonds via iron-catalysed sp C-H functionalization. Nature. PMID 30568304 DOI: 10.1038/S41586-018-0808-5  0.725
2018 Chen K, Zhang SQ, Brandenberg OF, Hong X, Arnold FH. Alternate heme ligation steers activity and selectivity in engineered cytochrome P450-catalyzed carbene transfer reactions. Journal of the American Chemical Society. PMID 30372623 DOI: 10.1021/Jacs.8B09613  0.525
2018 Zhang RK, Huang X, Arnold FH. Selective CH bond functionalization with engineered heme proteins: new tools to generate complexity. Current Opinion in Chemical Biology. 49: 67-75. PMID 30343008 DOI: 10.1016/J.Cbpa.2018.10.004  0.31
2018 Almhjell PJ, Boville CE, Arnold FH. Engineering enzymes for noncanonical amino acid synthesis. Chemical Society Reviews. PMID 30280154 DOI: 10.1039/C8Cs00665B  0.4
2018 Boville CE, Scheele RA, Koch P, Brinkmann-Chen S, Buller AR, Arnold FH. Engineered biosynthesis of β-alkyl tryptophan analogs. Angewandte Chemie (International Ed. in English). PMID 30215880 DOI: 10.1002/Anie.201807998  0.704
2018 Lewis RD, Garcia-Borràs M, Chalkley MJ, Buller AR, Houk KN, Kan SBJ, Arnold FH. Catalytic iron-carbene intermediate revealed in a cytochrome carbene transferase. Proceedings of the National Academy of Sciences of the United States of America. PMID 29946033 DOI: 10.1073/Pnas.1807027115  0.752
2018 Buller AR, van Roye P, Cahn JKB, Scheele RA, Herger M, Arnold FH. Directed evolution mimics allosteric activation by stepwise tuning of the conformational ensemble. Journal of the American Chemical Society. PMID 29712420 DOI: 10.1021/Jacs.8B03490  0.754
2018 Boville CE, Romney DK, Almhjell PJ, Sieben M, Arnold FH. Improved synthesis of 4-cyanotryptophan and other tryptophan analogs in aqueous solvent using variants of TrpB from Thermotoga maritima. The Journal of Organic Chemistry. PMID 29651849 DOI: 10.1021/Acs.Joc.8B00517  0.356
2018 Knight AM, Kan SBJ, Lewis RD, Brandenberg OF, Chen K, Arnold FH. Diverse Engineered Heme Proteins Enable Stereodivergent Cyclopropanation of Unactivated Alkenes. Acs Central Science. 4: 372-377. PMID 29632883 DOI: 10.1021/Acscentsci.7B00548  0.533
2018 Chen K, Huang X, Kan SBJ, Zhang RK, Arnold FH. Enzymatic construction of highly strained carbocycles. Science (New York, N.Y.). 360: 71-75. PMID 29622650 DOI: 10.1126/Science.Aar4239  0.42
2018 Cahn JKB, Brinkmann-Chen S, Arnold FH. Enzyme Nicotinamide Cofactor Specificity Reversal Guided by Automated Structural Analysis and Library Design. Methods in Molecular Biology (Clifton, N.J.). 1671: 15-26. PMID 29170950 DOI: 10.1007/978-1-4939-7295-1_2  0.376
2018 Boville CE, Scheele RA, Koch P, Brinkmann-Chen S, Buller AR, Arnold FH. Engineered Biosynthesis of beta-Alkyl Tryptophan Analogues. Angewandte Chemie. 57: 14764-14768. DOI: 10.2210/Pdb6Cuv/Pdb  0.681
2018 Brandenberg OF, Prier CK, Chen K, Knight AM, Wu Z, Arnold FH. Stereoselective Enzymatic Synthesis of Heteroatom-Substituted Cyclopropanes Acs Catalysis. 8: 2629-2634. DOI: 10.1021/Acscatal.7B04423  0.516
2017 Kan SBJ, Huang X, Gumulya Y, Chen K, Arnold FH. Genetically programmed chiral organoborane synthesis. Nature. 552: 132-136. PMID 29186119 DOI: 10.1038/Nature24996  0.496
2017 Bedbrook CN, Yang KK, Rice AJ, Gradinaru V, Arnold FH. Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization. Plos Computational Biology. 13: e1005786. PMID 29059183 DOI: 10.1371/Journal.Pcbi.1005786  0.622
2017 Hammer SC, Kubik G, Watkins E, Huang S, Minges H, Arnold FH. Anti-Markovnikov alkene oxidation by metal-oxo-mediated enzyme catalysis. Science (New York, N.Y.). 358: 215-218. PMID 29026041 DOI: 10.1126/Science.Aao1482  0.787
2017 Loskot SA, Romney DK, Arnold FH, Stoltz BM. Enantioselective Total Synthesis of Nigelladine A via Late-Stage C-H Oxidation Enabled by an Engineered P450 Enzyme. Journal of the American Chemical Society. PMID 28721734 DOI: 10.1021/Jacs.7B05196  0.403
2017 Brandenberg OF, Fasan R, Arnold FH. Exploiting and engineering hemoproteins for abiological carbene and nitrene transfer reactions. Current Opinion in Biotechnology. 47: 102-111. PMID 28711855 DOI: 10.1016/J.Copbio.2017.06.005  0.669
2017 Romney DK, Murciano-Calles J, Wehrmüller JE, Arnold FH. Unlocking reactivity of TrpB: a general biocatalytic platform for synthesis of tryptophan analogs. Journal of the American Chemical Society. PMID 28708383 DOI: 10.1021/Jacs.7B05007  0.415
2017 Prier CK, Zhang RK, Buller AR, Brinkmann-Chen S, Arnold FH. Enantioselective, intermolecular benzylic C-H amination catalysed by an engineered iron-haem enzyme. Nature Chemistry. 9: 629-634. PMID 28644476 DOI: 10.1038/Nchem.2783  0.718
2017 Bedbrook CN, Rice AJ, Yang KK, Ding X, Chen S, LeProust EM, Gradinaru V, Arnold FH. Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins. Proceedings of the National Academy of Sciences of the United States of America. PMID 28283661 DOI: 10.1073/Pnas.1700269114  0.636
2017 Herwig L, Rice AJ, Bedbrook CN, Zhang RK, Lignell A, Cahn JK, Renata H, Dodani SC, Cho I, Cai L, Gradinaru V, Arnold FH. Directed Evolution of a Bright Near-Infrared Fluorescent Rhodopsin Using a Synthetic Chromophore. Cell Chemical Biology. PMID 28262559 DOI: 10.1016/J.Chembiol.2017.02.008  0.77
2017 Hammer SC, Knight AM, Arnold FH. Design and evolution of enzymes for non-natural chemistry Current Opinion in Green and Sustainable Chemistry. 7: 23-30. DOI: 10.1016/J.Cogsc.2017.06.002  0.414
2016 Hernandez KE, Renata H, Lewis RD, Jennifer Kan SB, Zhang C, Forte J, Rozzell D, McIntosh JA, Arnold FH. Highly Stereoselective Biocatalytic Synthesis of Key Cyclopropane Intermediate to Ticagrelor. Acs Catalysis. 6: 7810-7813. PMID 28286694 DOI: 10.1021/Acscatal.6B02550  0.729
2016 Buller AR, van Roye P, Murciano-Calles J, Arnold FH. Tryptophan Synthase Uses an Atypical Mechanism To Achieve Substrate Specificity. Biochemistry. PMID 27935677 DOI: 10.1021/Acs.Biochem.6B01127  0.713
2016 Kan SB, Lewis RD, Chen K, Arnold FH. Directed evolution of cytochrome c for carbon-silicon bond formation: Bringing silicon to life. Science (New York, N.Y.). 354: 1048-1051. PMID 27885032 DOI: 10.1126/Science.Aah6219  0.445
2016 Cahn JK, Werlang CA, Baumschlager A, Brinkmann-Chen S, Mayo SL, Arnold FH. A general tool for engineering the NAD/NADP cofactor preference of oxidoreductases. Acs Synthetic Biology. PMID 27648601 DOI: 10.1021/Acssynbio.6B00188  0.632
2016 Renata H, Lewis RD, Sweredoski MJ, Moradian A, Hess S, Wang ZJ, Arnold FH. Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes. Journal of the American Chemical Society. PMID 27573353 DOI: 10.1021/Jacs.6B06823  0.78
2016 Murciano-Calles J, Romney DK, Brinkmann-Chen S, Buller AR, Arnold FH. A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation. Angewandte Chemie (International Ed. in English). PMID 27510733 DOI: 10.1002/Anie.201606242  0.757
2016 Moraïs S, Stern J, Kahn A, Galanopoulou AP, Yoav S, Shamshoum M, Smith MA, Hatzinikolaou DG, Arnold FH, Bayer EA. Enhancement of cellulosome-mediated deconstruction of cellulose by improving enzyme thermostability. Biotechnology For Biofuels. 9: 164. PMID 27493686 DOI: 10.1186/S13068-016-0577-Z  0.408
2016 Herger M, van Roye P, Romney DK, Brinkmann-Chen S, Buller AR, Arnold FH. Synthesis of β-branched tryptophan analogs using an engineered subunit of tryptophan synthase. Journal of the American Chemical Society. PMID 27355405 DOI: 10.1021/Jacs.6B04836  0.717
2016 Dodani SC, Kiss G, Cahn JK, Su Y, Pande VS, Arnold FH. Discovery of a regioselectivity switch in nitrating P450s guided by molecular dynamics simulations and Markov models. Nature Chemistry. 8: 419-25. PMID 27102675 DOI: 10.1038/Nchem.2474  0.412
2016 Chang CJ, Lee CC, Chan YT, Trudeau DL, Wu MH, Tsai CH, Yu SM, Ho TD, Wang AH, Hsiao CD, Arnold FH, Chao YC. Exploring the Mechanism Responsible for Cellulase Thermostability by Structure-Guided Recombination. Plos One. 11: e0147485. PMID 26986867 DOI: 10.1371/Journal.Pone.0147485  0.413
2016 Prier CK, Hyster TK, Farwell CC, Huang A, Arnold FH. Asymmetric Enzymatic Synthesis of Allylic Amines: A Sigmatropic Rearrangement Strategy. Angewandte Chemie (International Ed. in English). PMID 26970325 DOI: 10.1002/Anie.201601056  0.823
2016 Rice AJ, Bedbrook CN, Yang KK, Gradinaru V, Arnold FH. Rhodopsin Engineering through Structure-Guided Recombination Biophysical Journal. 110: 170a. DOI: 10.1016/J.Bpj.2015.11.947  0.648
2015 Cahn JK, Brinkmann-Chen S, Buller AR, Arnold FH. Artificial domain duplication replicates evolutionary history of ketol-acid reductoisomerases. Protein Science : a Publication of the Protein Society. PMID 26644020 DOI: 10.1002/Pro.2852  0.703
2015 Buller AR, Brinkmann-Chen S, Romney DK, Herger M, Murciano-Calles J, Arnold FH. Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 26553994 DOI: 10.1073/Pnas.1516401112  0.729
2015 Arnold FH. The nature of chemical innovation: new enzymes by evolution. Quarterly Reviews of Biophysics. 48: 404-10. PMID 26537398 DOI: 10.1017/S003358351500013X  0.439
2015 Cahn JK, Baumschlager A, Brinkmann-Chen S, Arnold FH. Mutations in adenine-binding pockets enhance catalytic properties of NAD(P)H-dependent enzymes. Protein Engineering, Design & Selection : Peds. PMID 26512129 DOI: 10.1093/Protein/Gzv057  0.433
2015 Prier CK, Arnold FH. Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts. Journal of the American Chemical Society. PMID 26502343 DOI: 10.1021/Jacs.5B09348  0.392
2015 Farwell CC, Zhang RK, McIntosh JA, Hyster TK, Arnold FH. Enantioselective Enzyme-Catalyzed Aziridination Enabled by Active-Site Evolution of a Cytochrome P450. Acs Central Science. 1: 89-93. PMID 26405689 DOI: 10.1021/Acscentsci.5B00056  0.834
2015 McIntosh JA, Heel T, Buller AR, Chio L, Arnold FH. Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450. Journal of the American Chemical Society. PMID 26299431 DOI: 10.1021/Jacs.5B07107  0.749
2015 McIsaac RS, Bedbrook CN, Arnold FH. Recent advances in engineering microbial rhodopsins for optogenetics. Current Opinion in Structural Biology. 33: 8-15. PMID 26038227 DOI: 10.1016/J.Sbi.2015.05.001  0.362
2015 Cahn JK, Brinkmann-Chen S, Spatzal T, Wiig JA, Buller AR, Einsle O, Hu Y, Ribbe MW, Arnold FH. Cofactor specificity motifs and the induced fit mechanism in Class I ketol-acid reductoisomerases. The Biochemical Journal. PMID 25849365 DOI: 10.1042/Bj20150183  0.712
2015 Renata H, Wang ZJ, Arnold FH. Expanding the enzyme universe: accessing non-natural reactions by mechanism-guided directed evolution. Angewandte Chemie (International Ed. in English). 54: 3351-67. PMID 25649694 DOI: 10.1002/Anie.201409470  0.726
2015 Engqvist MK, McIsaac RS, Dollinger P, Flytzanis NC, Abrams M, Schor S, Arnold FH. Directed evolution of Gloeobacter violaceus rhodopsin spectral properties. Journal of Molecular Biology. 427: 205-20. PMID 24979679 DOI: 10.1016/J.Jmb.2014.06.015  0.327
2015 Hyster TK, Arnold FH. P450BM3-axial mutations: A gateway to non-natural reactivity Israel Journal of Chemistry. 55: 14-20. DOI: 10.1002/Ijch.201400080  0.716
2015 Renata H, Wang ZJ, Arnold FH. Ausdehnung des Enzym-Universums: Zugang zu nicht-natürlichen Reaktionen durch mechanismusgeleitete, gerichtete Evolution Angewandte Chemie. 127: 3408-3426. DOI: 10.1002/Ange.201409470  0.66
2014 Hyster TK, Farwell CC, Buller AR, McIntosh JA, Arnold FH. Enzyme-controlled nitrogen-atom transfer enables regiodivergent C-H amination. Journal of the American Chemical Society. 136: 15505-8. PMID 25325618 DOI: 10.1021/Ja509308V  0.788
2014 Heel T, McIntosh JA, Dodani SC, Meyerowitz JT, Arnold FH. Non-natural olefin cyclopropanation catalyzed by diverse cytochrome P450s and other hemoproteins. Chembiochem : a European Journal of Chemical Biology. 15: 2556-62. PMID 25294253 DOI: 10.1002/Cbic.201402286  0.436
2014 Renata H, Wang ZJ, Kitto RZ, Arnold FH. P450-catalyzed asymmetric cyclopropanation of electron-deficient olefins under aerobic conditions. Catalysis Science & Technology. 4: 3640-3643. PMID 25221671 DOI: 10.1039/C4Cy00633J  0.745
2014 Dodani SC, Cahn JK, Heinisch T, Brinkmann-Chen S, McIntosh JA, Arnold FH. Structural, functional, and spectroscopic characterization of the substrate scope of the novel nitrating cytochrome P450 TxtE. Chembiochem : a European Journal of Chemical Biology. 15: 2259-67. PMID 25182183 DOI: 10.1002/Cbic.201402241  0.44
2014 Brinkmann-Chen S, Cahn JK, Arnold FH. Uncovering rare NADH-preferring ketol-acid reductoisomerases. Metabolic Engineering. 26: 17-22. PMID 25172159 DOI: 10.1016/J.Ymben.2014.08.003  0.398
2014 Smith MA, Arnold FH. Noncontiguous SCHEMA protein recombination. Methods in Molecular Biology (Clifton, N.J.). 1179: 345-52. PMID 25055789 DOI: 10.1007/978-1-4939-1053-3_23  0.338
2014 Smith MA, Arnold FH. Designing libraries of chimeric proteins using SCHEMA recombination and RASPP. Methods in Molecular Biology (Clifton, N.J.). 1179: 335-43. PMID 25055788 DOI: 10.1007/978-1-4939-1053-3_22  0.322
2014 Sun F, Zhang WB, Mahdavi A, Arnold FH, Tirrell DA. Synthesis of bioactive protein hydrogels by genetically encoded SpyTag-SpyCatcher chemistry. Proceedings of the National Academy of Sciences of the United States of America. 111: 11269-74. PMID 25049400 DOI: 10.1073/Pnas.1401291111  0.328
2014 Trudeau DL, Lee TM, Arnold FH. Engineered thermostable fungal cellulases exhibit efficient synergistic cellulose hydrolysis at elevated temperatures. Biotechnology and Bioengineering. 111: 2390-7. PMID 24916885 DOI: 10.1002/Bit.25308  0.341
2014 Farwell CC, McIntosh JA, Hyster TK, Wang ZJ, Arnold FH. Enantioselective imidation of sulfides via enzyme-catalyzed intermolecular nitrogen-atom transfer. Journal of the American Chemical Society. 136: 8766-71. PMID 24901646 DOI: 10.1021/Ja503593N  0.826
2014 Wang ZJ, Renata H, Peck NE, Farwell CC, Coelho PS, Arnold FH. Improved cyclopropanation activity of histidine-ligated cytochrome P450 enables the enantioselective formal synthesis of levomilnacipran. Angewandte Chemie (International Ed. in English). 53: 6810-3. PMID 24802161 DOI: 10.1002/Anie.201402809  0.826
2014 Lin PP, Rabe KS, Takasumi JL, Kadisch M, Arnold FH, Liao JC. Isobutanol production at elevated temperatures in thermophilic Geobacillus thermoglucosidasius. Metabolic Engineering. 24: 1-8. PMID 24721011 DOI: 10.1016/J.Ymben.2014.03.006  0.332
2014 McIntosh JA, Farwell CC, Arnold FH. Expanding P450 catalytic reaction space through evolution and engineering. Current Opinion in Chemical Biology. 19: 126-34. PMID 24658056 DOI: 10.1016/J.Cbpa.2014.02.001  0.775
2014 Wang ZJ, Peck NE, Renata H, Arnold FH. Cytochrome P450-Catalyzed Insertion of Carbenoids into N-H Bonds. Chemical Science (Royal Society of Chemistry : 2010). 5: 598-601. PMID 24490022 DOI: 10.1039/C3Sc52535J  0.742
2014 Coelho PS, Wang ZJ, Ener ME, Baril SA, Kannan A, Arnold FH, Brustad EM. Erratum: Corrigendum: A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo Nature Chemical Biology. 10: 164-164. DOI: 10.1038/Nchembio0214-164D  0.787
2014 Coelho PS, Arnold FH, Lewis JC. Synthetic Biology Approaches for Organic Synthesis Comprehensive Organic Synthesis: Second Edition. 9: 390-420. DOI: 10.1016/B978-0-08-097742-3.00931-9  0.451
2014 Wang ZJ, Renata H, Peck NE, Farwell CC, Coelho PS, Arnold FH. Cover Picture: Improved Cyclopropanation Activity of Histidine-Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran (Angew. Chem. Int. Ed. 26/2014) Angewandte Chemie International Edition. 53: 6571-6571. DOI: 10.1002/Anie.201404337  0.796
2014 Wang ZJ, Renata H, Peck NE, Farwell CC, Coelho PS, Arnold FH. Titelbild: Improved Cyclopropanation Activity of Histidine-Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran (Angew. Chem. 26/2014) Angewandte Chemie. 126: 6689-6689. DOI: 10.1002/Ange.201404337  0.799
2013 Trudeau DL, Smith MA, Arnold FH. Innovation by homologous recombination. Current Opinion in Chemical Biology. 17: 902-9. PMID 24182747 DOI: 10.1016/J.Cbpa.2013.10.007  0.393
2013 Zhang WB, Sun F, Tirrell DA, Arnold FH. Controlling macromolecular topology with genetically encoded SpyTag-SpyCatcher chemistry. Journal of the American Chemical Society. 135: 13988-97. PMID 23964715 DOI: 10.1021/Ja4076452  0.361
2013 McIntosh JA, Coelho PS, Farwell CC, Wang ZJ, Lewis JC, Brown TR, Arnold FH. Enantioselective intramolecular C-H amination catalyzed by engineered cytochrome P450 enzymes in vitro and in vivo. Angewandte Chemie (International Ed. in English). 52: 9309-12. PMID 23893546 DOI: 10.1002/Anie.201304401  0.813
2013 Coelho PS, Wang ZJ, Ener ME, Baril SA, Kannan A, Arnold FH, Brustad EM. A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo. Nature Chemical Biology. 9: 485-7. PMID 23792734 DOI: 10.1038/Nchembio.1278  0.799
2013 Brinkmann-Chen S, Flock T, Cahn JK, Snow CD, Brustad EM, McIntosh JA, Meinhold P, Zhang L, Arnold FH. General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH. Proceedings of the National Academy of Sciences of the United States of America. 110: 10946-51. PMID 23776225 DOI: 10.1073/Pnas.1306073110  0.814
2013 Smith MA, Bedbrook CN, Wu T, Arnold FH. Hypocrea jecorina cellobiohydrolase I stabilizing mutations identified using noncontiguous recombination. Acs Synthetic Biology. 2: 690-6. PMID 23688124 DOI: 10.1021/Sb400010M  0.368
2013 Wu I, Heel T, Arnold FH. Role of cysteine residues in thermal inactivation of fungal Cel6A cellobiohydrolases. Biochimica Et Biophysica Acta. 1834: 1539-44. PMID 23676789 DOI: 10.1016/J.Bbapap.2013.05.003  0.609
2013 Lauchli R, Rabe KS, Kalbarczyk KZ, Tata A, Heel T, Kitto RZ, Arnold FH. High-throughput screening for terpene-synthase-cyclization activity and directed evolution of a terpene synthase. Angewandte Chemie (International Ed. in English). 52: 5571-4. PMID 23532864 DOI: 10.1002/Anie.201301362  0.793
2013 Romero PA, Shapiro MG, Arnold FH, Jasanoff A. Directed evolution of protein-based neurotransmitter sensors for MRI. Methods in Molecular Biology (Clifton, N.J.). 995: 193-205. PMID 23494381 DOI: 10.1007/978-1-62703-345-9_14  0.626
2013 Heinzelman P, Romero PA, Arnold FH. Efficient sampling of SCHEMA chimera families to identify useful sequence elements. Methods in Enzymology. 523: 351-68. PMID 23422438 DOI: 10.1016/B978-0-12-394292-0.00016-3  0.609
2013 Wu I, Arnold FH. Engineered thermostable fungal Cel6A and Cel7A cellobiohydrolases hydrolyze cellulose efficiently at elevated temperatures. Biotechnology and Bioengineering. 110: 1874-83. PMID 23404363 DOI: 10.1002/Bit.24864  0.603
2013 Romero PA, Krause A, Arnold FH. Navigating the protein fitness landscape with Gaussian processes. Proceedings of the National Academy of Sciences of the United States of America. 110: E193-201. PMID 23277561 DOI: 10.1073/Pnas.1215251110  0.659
2013 Coelho PS, Brustad EM, Kannan A, Arnold FH. Olefin cyclopropanation via carbene transfer catalyzed by engineered cytochrome P450 enzymes. Science (New York, N.Y.). 339: 307-10. PMID 23258409 DOI: 10.1126/Science.1231434  0.737
2013 Smith MA, Romero PA, Wu T, Brustad EM, Arnold FH. Chimeragenesis of distantly-related proteins by noncontiguous recombination. Protein Science : a Publication of the Protein Society. 22: 231-8. PMID 23225662 DOI: 10.1002/Pro.2202  0.787
2013 Lauchli R, Rabe KS, Kalbarczyk KZ, Tata A, Heel T, Kitto RZ, Arnold FH. Innenrücktitelbild: High-Throughput Screening for Terpene-Synthase-Cyclization Activity and Directed Evolution of a Terpene Synthase (Angew. Chem. 21/2013) Angewandte Chemie. 125: 5759-5759. DOI: 10.1002/Ange.201303270  0.305
2012 Smith MA, Rentmeister A, Snow CD, Wu T, Farrow MF, Mingardon F, Arnold FH. A diverse set of family 48 bacterial glycoside hydrolase cellulases created by structure-guided recombination. The Febs Journal. 279: 4453-65. PMID 23075376 DOI: 10.1111/Febs.12032  0.416
2012 Romero PA, Arnold FH. Random field model reveals structure of the protein recombinational landscape. Plos Computational Biology. 8: e1002713. PMID 23055915 DOI: 10.1371/Journal.Pcbi.1002713  0.652
2012 Liu X, Bastian S, Snow CD, Brustad EM, Saleski TE, Xu JH, Meinhold P, Arnold FH. Structure-guided engineering of Lactococcus lactis alcohol dehydrogenase LlAdhA for improved conversion of isobutyraldehyde to isobutanol. Journal of Biotechnology. 164: 188-95. PMID 22974724 DOI: 10.1016/J.Jbiotec.2012.08.008  0.805
2012 Komor RS, Romero PA, Xie CB, Arnold FH. Highly thermostable fungal cellobiohydrolase I (Cel7A) engineered using predictive methods. Protein Engineering, Design & Selection : Peds. 25: 827-33. PMID 22961332 DOI: 10.1093/Protein/Gzs058  0.791
2012 Romero PA, Stone E, Lamb C, Chantranupong L, Krause A, Miklos AE, Hughes RA, Fechtel B, Ellington AD, Arnold FH, Georgiou G. SCHEMA-designed variants of human Arginase I and II reveal sequence elements important to stability and catalysis. Acs Synthetic Biology. 1: 221-8. PMID 22737599 DOI: 10.1021/Sb300014T  0.698
2012 Brustad EM, Lelyveld VS, Snow CD, Crook N, Jung ST, Martinez FM, Scholl TJ, Jasanoff A, Arnold FH. Structure-guided directed evolution of highly selective p450-based magnetic resonance imaging sensors for dopamine and serotonin. Journal of Molecular Biology. 422: 245-62. PMID 22659321 DOI: 10.1016/J.Jmb.2012.05.029  0.792
2012 Chen MM, Snow CD, Vizcarra CL, Mayo SL, Arnold FH. Comparison of random mutagenesis and semi-rational designed libraries for improved cytochrome P450 BM3-catalyzed hydroxylation of small alkanes. Protein Engineering, Design & Selection : Peds. 25: 171-8. PMID 22334757 DOI: 10.1093/Protein/Gzs004  0.646
2012 Bastian S, Arnold FH. Reversal of NAD(P)H cofactor dependence by protein engineering. Methods in Molecular Biology (Clifton, N.J.). 834: 17-31. PMID 22144350 DOI: 10.1007/978-1-61779-483-4_2  0.412
2012 Arnold FH. The Library of Maynard-Smith Microbe Magazine. 6: 203-208. DOI: 10.1128/9781555818470.Ch28  0.331
2012 Chen MM, Coelho PS, Arnold FH. Utilizing terminal oxidants to achieve P450-catalyzed oxidation of methane Advanced Synthesis and Catalysis. 354: 964-968. DOI: 10.1002/Adsc.201100833  0.353
2011 Lee TM, Farrow MF, Arnold FH, Mayo SL. A structural study of Hypocrea jecorina Cel5A. Protein Science : a Publication of the Protein Society. 20: 1935-40. PMID 21898652 DOI: 10.1002/Pro.730  0.619
2011 Farrow MF, Arnold FH. High throughput screening of fungal endoglucanase activity in Escherichia coli. Journal of Visualized Experiments : Jove. PMID 21860379 DOI: 10.3791/2942  0.4
2011 Bastian S, Liu X, Meyerowitz JT, Snow CD, Chen MM, Arnold FH. Engineered ketol-acid reductoisomerase and alcohol dehydrogenase enable anaerobic 2-methylpropan-1-ol production at theoretical yield in Escherichia coli. Metabolic Engineering. 13: 345-52. PMID 21515217 DOI: 10.1016/J.Ymben.2011.02.004  0.356
2011 Jung ST, Lauchli R, Arnold FH. Cytochrome P450: taming a wild type enzyme. Current Opinion in Biotechnology. 22: 809-17. PMID 21411308 DOI: 10.1016/J.Copbio.2011.02.008  0.746
2011 Fasan R, Crook NC, Peters MW, Meinhold P, Buelter T, Landwehr M, Cirino PC, Arnold FH. Improved product-per-glucose yields in P450-dependent propane biotransformations using engineered Escherichia coli. Biotechnology and Bioengineering. 108: 500-10. PMID 21246504 DOI: 10.1002/Bit.22984  0.792
2011 Brustad EM, Arnold FH. Optimizing non-natural protein function with directed evolution. Current Opinion in Chemical Biology. 15: 201-10. PMID 21185770 DOI: 10.1016/J.Cbpa.2010.11.020  0.733
2011 Lelyveld VS, Brustad E, Arnold FH, Jasanoff A. Metal-substituted protein MRI contrast agents engineered for enhanced relaxivity and ligand sensitivity. Journal of the American Chemical Society. 133: 649-51. PMID 21171606 DOI: 10.1021/Ja107936D  0.72
2011 Mingardon F, Bagert JD, Maisonnier C, Trudeau DL, Arnold FH. Comparison of family 9 cellulases from mesophilic and thermophilic bacteria. Applied and Environmental Microbiology. 77: 1436-42. PMID 21169454 DOI: 10.1128/Aem.01802-10  0.354
2011 Lewis JC, Coelho PS, Arnold FH. Enzymatic functionalization of carbon-hydrogen bonds. Chemical Society Reviews. 40: 2003-21. PMID 21079862 DOI: 10.1039/C0Cs00067A  0.604
2011 Rentmeister A, Brown TR, Snow CD, Carbone MN, Arnold FH. Engineered Bacterial Mimics of Human Drug Metabolizing Enzyme CYP2C9 Chemcatchem. 3: 1065-1071. DOI: 10.1002/Cctc.201000452  0.818
2011 Saab-Rincon G, Li Y, Meyer M, Carbone M, Landwehr M, Arnold FH. Protein Engineering by Structure-Guided SCHEMA Recombination Protein Engineering Handbook, Volume 1 & Volume 2. 2: 481-492. DOI: 10.1002/9783527634026.ch20  0.792
2010 Lewis JC, Mantovani SM, Fu Y, Snow CD, Komor RS, Wong CH, Arnold FH. Combinatorial alanine substitution enables rapid optimization of cytochrome P450BM3 for selective hydroxylation of large substrates. Chembiochem : a European Journal of Chemical Biology. 11: 2502-5. PMID 21108271 DOI: 10.1002/Cbic.201000565  0.813
2010 Heinzelman P, Komor R, Kanaan A, Romero P, Yu X, Mohler S, Snow C, Arnold F. Efficient screening of fungal cellobiohydrolase class i enzymes for thermostabilizing sequence blocks by SCHEMA structure-guided recombination Protein Engineering, Design and Selection. 23: 871-880. PMID 20847102 DOI: 10.1093/Protein/Gzq063  0.805
2010 Jäckel C, Bloom JD, Kast P, Arnold FH, Hilvert D. Consensus protein design without phylogenetic bias. Journal of Molecular Biology. 399: 541-6. PMID 20433850 DOI: 10.1016/J.Jmb.2010.04.039  0.608
2010 Shapiro MG, Westmeyer GG, Romero PA, Szablowski JO, Küster B, Shah A, Otey CR, Langer R, Arnold FH, Jasanoff A. Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine. Nature Biotechnology. 28: 264-70. PMID 20190737 DOI: 10.1038/Nbt.1609  0.773
2010 MALLIK S, PLUNKETT SD, DHAL PK, JOHNSON RD, PACK D, SHNEK D, ARNOLD FH. ChemInform Abstract: Towards Materials for the Specific Recognition and Separation of Proteins Cheminform. 25: no-no. DOI: 10.1002/chin.199430304  0.532
2009 Arnold FH. How proteins adapt: lessons from directed evolution. Cold Spring Harbor Symposia On Quantitative Biology. 74: 41-6. PMID 20413708 DOI: 10.1101/Sqb.2009.74.046  0.326
2009 Romero PA, Arnold FH. Exploring protein fitness landscapes by directed evolution. Nature Reviews. Molecular Cell Biology. 10: 866-76. PMID 19935669 DOI: 10.1038/Nrm2805  0.646
2009 Lewis JC, Bastian S, Bennett CS, Fu Y, Mitsuda Y, Chen MM, Greenberg WA, Wong CH, Arnold FH. Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450BM3 demethylases. Proceedings of the National Academy of Sciences of the United States of America. 106: 16550-5. PMID 19805336 DOI: 10.1073/Pnas.0908954106  0.619
2009 Sawayama AM, Chen MM, Kulanthaivel P, Kuo MS, Hemmerle H, Arnold FH. A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 11723-9. PMID 19774562 DOI: 10.1002/Chem.200900643  0.372
2009 Dougherty MJ, Arnold FH. Directed evolution: new parts and optimized function. Current Opinion in Biotechnology. 20: 486-91. PMID 19720520 DOI: 10.1016/J.Copbio.2009.08.005  0.314
2009 Heinzelman P, Snow CD, Smith MA, Yu X, Kannan A, Boulware K, Villalobos A, Govindarajan S, Minshull J, Arnold FH. SCHEMA recombination of a fungal cellulase uncovers a single mutation that contributes markedly to stability. The Journal of Biological Chemistry. 284: 26229-33. PMID 19625252 DOI: 10.1074/Jbc.C109.034058  0.345
2009 Bloom JD, Arnold FH. In the light of directed evolution: pathways of adaptive protein evolution. Proceedings of the National Academy of Sciences of the United States of America. 106: 9995-10000. PMID 19528653 DOI: 10.1073/Pnas.0901522106  0.592
2009 Heinzelman P, Snow CD, Wu I, Nguyen C, Villalobos A, Govindarajan S, Minshull J, Arnold FH. A family of thermostable fungal cellulases created by structure-guided recombination. Proceedings of the National Academy of Sciences of the United States of America. 106: 5610-5. PMID 19307582 DOI: 10.1073/Pnas.0901417106  0.635
2009 Tracewell CA, Arnold FH. Directed enzyme evolution: climbing fitness peaks one amino acid at a time. Current Opinion in Chemical Biology. 13: 3-9. PMID 19249235 DOI: 10.1016/J.Cbpa.2009.01.017  0.419
2009 Rentmeister A, Arnold FH, Fasan R. Chemo-enzymatic fluorination of unactivated organic compounds. Nature Chemical Biology. 5: 26-8. PMID 19011638 DOI: 10.1038/Nchembio.128  0.598
2009 Koch DJ, Chen MM, van Beilen JB, Arnold FH. In vivo evolution of butane oxidation by terminal alkane hydroxylases AlkB and CYP153A6. Applied and Environmental Microbiology. 75: 337-44. PMID 19011057 DOI: 10.1128/Aem.01758-08  0.41
2009 Arnold FH, Lewis JC. Catalysts on demand: Selective oxidations by laboratory-evolved cytochrome P450 BM3 Chimia. 63: 309-312. DOI: 10.2533/Chimia.2009.309  0.598
2009 Brenner K, You L, Arnold FH. Response to Goldman and Brown: Making sense of microbial consortia using ecology and evolution Trends in Biotechnology. 27: 4. DOI: 10.1016/J.Tibtech.2008.10.004  0.511
2008 Brenner K, You L, Arnold FH. Engineering microbial consortia: a new frontier in synthetic biology. Trends in Biotechnology. 26: 483-9. PMID 18675483 DOI: 10.1016/J.Tibtech.2008.05.004  0.523
2008 Fasan R, Meharenna YT, Snow CD, Poulos TL, Arnold FH. Evolutionary history of a specialized p450 propane monooxygenase. Journal of Molecular Biology. 383: 1069-80. PMID 18619466 DOI: 10.1016/J.Jmb.2008.06.060  0.693
2008 Balagaddé FK, Song H, Ozaki J, Collins CH, Barnet M, Arnold FH, Quake SR, You L. A synthetic Escherichia coli predator-prey ecosystem. Molecular Systems Biology. 4: 187. PMID 18414488 DOI: 10.1038/Msb.2008.24  0.644
2008 May O, Voigt CA, Arnold FH. Enzyme engineering by directed evolution Enzyme Catalysis in Organic Synthesis: Second Edition. 95-138. DOI: 10.1002/9783527618262.ch4  0.534
2007 Fasan R, Chen MM, Crook NC, Arnold FH. Engineered alkane-hydroxylating cytochrome P450(BM3) exhibiting nativelike catalytic properties. Angewandte Chemie (International Ed. in English). 46: 8414-8. PMID 17886313 DOI: 10.1002/Anie.200702616  0.646
2007 Carbone MN, Arnold FH. Engineering by homologous recombination: exploring sequence and function within a conserved fold. Current Opinion in Structural Biology. 17: 454-9. PMID 17884462 DOI: 10.1016/J.Sbi.2007.08.005  0.813
2007 Li Y, Drummond DA, Sawayama AM, Snow CD, Bloom JD, Arnold FH. A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments. Nature Biotechnology. 25: 1051-6. PMID 17721510 DOI: 10.1038/Nbt1333  0.74
2007 Bloom JD, Lu Z, Chen D, Raval A, Venturelli OS, Arnold FH. Evolution favors protein mutational robustness in sufficiently large populations. Bmc Biology. 5: 29. PMID 17640347 DOI: 10.1186/1741-7007-5-29  0.57
2007 Bloom JD, Romero PA, Lu Z, Arnold FH. Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution. Biology Direct. 2: 17. PMID 17598905 DOI: 10.1186/1745-6150-2-17  0.752
2007 Landwehr M, Carbone M, Otey CR, Li Y, Arnold FH. Diversification of catalytic function in a synthetic family of chimeric cytochrome p450s. Chemistry & Biology. 14: 269-78. PMID 17379142 DOI: 10.1016/J.Chembiol.2007.01.009  0.804
2007 Bloom JD, Arnold FH, Wilke CO. Breaking proteins with mutations: threads and thresholds in evolution. Molecular Systems Biology. 3: 76. PMID 17262035 DOI: 10.1038/Msb4100119  0.526
2007 Li Y, Drummond DA, Sawayama AM, Snow CD, Bloom JD, Arnold FH. Erratum: Corrigendum: A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments Nature Biotechnology. 25: 1488-1488. DOI: 10.1038/Nbt1207-1488D  0.677
2007 Fasan R, Arnold FH. Laboratory evolution of P450 alkane monooxygenases Acs National Meeting Book of Abstracts 0.565
2006 Meyer MM, Hiraga K, Arnold FH. Combinatorial recombination of gene fragments to construct a library of chimeras. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 26.2. PMID 18429308 DOI: 10.1002/0471140864.Ps2602S44  0.53
2006 Meyer MM, Hochrein L, Arnold FH. Structure-guided SCHEMA recombination of distantly related beta-lactamases. Protein Engineering, Design & Selection : Peds. 19: 563-70. PMID 17090554 DOI: 10.1093/Protein/Gzl045  0.57
2006 Bloom JD, Drummond DA, Arnold FH, Wilke CO. Structural determinants of the rate of protein evolution in yeast. Molecular Biology and Evolution. 23: 1751-61. PMID 16782762 DOI: 10.1093/Molbev/Msl040  0.688
2006 Collins CH, Leadbetter JR, Arnold FH. Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR. Nature Biotechnology. 24: 708-12. PMID 16715074 DOI: 10.1038/Nbt1209  0.557
2006 Landwehr M, Hochrein L, Otey CR, Kasrayan A, Bäckvall JE, Arnold FH. Enantioselective alpha-hydroxylation of 2-arylacetic acid derivatives and buspirone catalyzed by engineered cytochrome P450 BM-3. Journal of the American Chemical Society. 128: 6058-9. PMID 16669674 DOI: 10.1021/Ja061261X  0.337
2006 Otey CR, Landwehr M, Endelman JB, Hiraga K, Bloom JD, Arnold FH. Structure-guided recombination creates an artificial family of cytochromes P450. Plos Biology. 4: e112. PMID 16594730 DOI: 10.1371/Journal.Pbio.0040112  0.778
2006 Bloom JD, Labthavikul ST, Otey CR, Arnold FH. Protein stability promotes evolvability. Proceedings of the National Academy of Sciences of the United States of America. 103: 5869-74. PMID 16581913 DOI: 10.1073/Pnas.0510098103  0.601
2006 Tobias AV, Arnold FH. Biosynthesis of novel carotenoid families based on unnatural carbon backbones: a model for diversification of natural product pathways. Biochimica Et Biophysica Acta. 1761: 235-46. PMID 16478677 DOI: 10.1016/J.Bbalip.2006.01.003  0.774
2006 Kubo T, Peters MW, Meinhold P, Arnold FH. Enantioselective epoxidation of terminal alkenes to (R)- and (S)-epoxides by engineered cytochromes P450 BM-3. Chemistry (Weinheim An Der Bergstrasse, Germany). 12: 1216-20. PMID 16240317 DOI: 10.1002/Chem.200500584  0.729
2006 Otey CR, Bandara G, Lalonde J, Takahashi K, Arnold FH. Preparation of human metabolites of propranolol using laboratory-evolved bacterial cytochromes P450. Biotechnology and Bioengineering. 93: 494-9. PMID 16224788 DOI: 10.1002/Bit.20744  0.338
2006 Collins CH, Leadbetter JR, Arnold FH. Correction: Corrigendum: Dual selection enhances the signaling specificity of a variant of the quorum-sensing transcriptional activator LuxR Nature Biotechnology. 24: 1033-1033. DOI: 10.1038/Nbt0806-1033C  0.543
2006 Meinhold P, Peters MW, Hartwick A, Hernandez AR, Arnold FH. Engineering cytochrome P450 BM3 for terminal alkane hydroxylation Advanced Synthesis and Catalysis. 348: 763-772. DOI: 10.1002/Adsc.200505465  0.741
2005 Drummond DA, Bloom JD, Adami C, Wilke CO, Arnold FH. Why highly expressed proteins evolve slowly. Proceedings of the National Academy of Sciences of the United States of America. 102: 14338-43. PMID 16176987 DOI: 10.1073/Pnas.0504070102  0.74
2005 Meinhold P, Peters MW, Chen MM, Takahashi K, Arnold FH. Direct conversion of ethane to ethanol by engineered cytochrome P450 BM3. Chembiochem : a European Journal of Chemical Biology. 6: 1765-8. PMID 16080215 DOI: 10.1002/Cbic.200500261  0.702
2005 Bloom JD, Meyer MM, Meinhold P, Otey CR, MacMillan D, Arnold FH. Evolving strategies for enzyme engineering. Current Opinion in Structural Biology. 15: 447-52. PMID 16006119 DOI: 10.1016/J.Sbi.2005.06.004  0.824
2005 Balagaddé FK, You L, Hansen CL, Arnold FH, Quake SR. Long-term monitoring of bacteria undergoing programmed population control in a microchemostat. Science (New York, N.Y.). 309: 137-40. PMID 15994559 DOI: 10.1126/Science.1109173  0.478
2005 Drummond DA, Iverson BL, Georgiou G, Arnold FH. Why high-error-rate random mutagenesis libraries are enriched in functional and improved proteins. Journal of Molecular Biology. 350: 806-16. PMID 15939434 DOI: 10.1016/J.Jmb.2005.05.023  0.639
2005 Udit AK, Hindoyan N, Hill MG, Arnold FH, Gray HB. Protein-surfactant film voltammetry of wild-type and mutant cytochrome P450 BM3. Inorganic Chemistry. 44: 4109-11. PMID 15934729 DOI: 10.1021/Ic0483747  0.773
2005 Münzer DF, Meinhold P, Peters MW, Feichtenhofer S, Griengl H, Arnold FH, Glieder A, de Raadt A. Stereoselective hydroxylation of an achiral cyclopentanecarboxylic acid derivative using engineered P450s BM-3. Chemical Communications (Cambridge, England). 2597-9. PMID 15900339 DOI: 10.1039/B501527H  0.728
2005 Basu S, Gerchman Y, Collins CH, Arnold FH, Weiss R. A synthetic multicellular system for programmed pattern formation. Nature. 434: 1130-4. PMID 15858574 DOI: 10.1038/Nature03461  0.549
2005 Drummond DA, Silberg JJ, Meyer MM, Wilke CO, Arnold FH. On the conservative nature of intragenic recombination. Proceedings of the National Academy of Sciences of the United States of America. 102: 5380-5. PMID 15809422 DOI: 10.1073/Pnas.0500729102  0.789
2005 Umeno D, Tobias AV, Arnold FH. Diversifying carotenoid biosynthetic pathways by directed evolution. Microbiology and Molecular Biology Reviews : Mmbr. 69: 51-78. PMID 15755953 DOI: 10.1128/Mmbr.69.1.51-78.2005  0.776
2005 Collins CH, Arnold FH, Leadbetter JR. Directed evolution of Vibrio fischeri LuxR for increased sensitivity to a broad spectrum of acyl-homoserine lactones. Molecular Microbiology. 55: 712-23. PMID 15660998 DOI: 10.1111/J.1365-2958.2004.04437.X  0.58
2005 Bloom JD, Silberg JJ, Wilke CO, Drummond DA, Adami C, Arnold FH. Thermodynamic prediction of protein neutrality. Proceedings of the National Academy of Sciences of the United States of America. 102: 606-11. PMID 15644440 DOI: 10.1073/Pnas.0406744102  0.79
2005 Yokobayashi Y, Arnold FH. A dual selection module for directed evolution of genetic circuits Natural Computing. 4: 245-254. DOI: 10.1007/S11047-004-7442-X  0.603
2005 Ozaki J, Barnet M, Collins CH, Arnold FH, You L. A synthetic E.Coli predator-prey system Aiche Annual Meeting, Conference Proceedings. 11590.  0.442
2004 Udit AK, Arnold FH, Gray HB. Cobaltocene-mediated catalytic monooxygenation using holo and heme domain cytochrome P450 BM3. Journal of Inorganic Biochemistry. 98: 1547-50. PMID 15337607 DOI: 10.1016/J.Jinorgbio.2004.06.007  0.753
2004 Endelman JB, Silberg JJ, Wang ZG, Arnold FH. Site-directed protein recombination as a shortest-path problem. Protein Engineering, Design & Selection : Peds. 17: 589-94. PMID 15331774 DOI: 10.1093/Protein/Gzh067  0.787
2004 Udit AK, Hill MG, Bittner VG, Arnold FH, Gray HB. Reduction of dioxygen catalyzed by pyrene-wired heme domain cytochrome P450 BM3 electrodes. Journal of the American Chemical Society. 126: 10218-9. PMID 15315414 DOI: 10.1021/Ja0466560  0.776
2004 Silberg JJ, Endelman JB, Arnold FH. SCHEMA-guided protein recombination. Methods in Enzymology. 388: 35-42. PMID 15289059 DOI: 10.1016/S0076-6879(04)88004-2  0.792
2004 Otey CR, Silberg JJ, Voigt CA, Endelman JB, Bandara G, Arnold FH. Functional evolution and structural conservation in chimeric cytochromes p450: calibrating a structure-guided approach. Chemistry & Biology. 11: 309-18. PMID 15123260 DOI: 10.1016/J.Chembiol.2004.02.018  0.812
2004 Bloom JD, Wilke CO, Arnold FH, Adami C. Stability and the evolvability of function in a model protein. Biophysical Journal. 86: 2758-64. PMID 15111394 DOI: 10.1016/S0006-3495(04)74329-5  0.667
2004 You L, Cox RS, Weiss R, Arnold FH. Programmed population control by cell-cell communication and regulated killing. Nature. 428: 868-71. PMID 15064770 DOI: 10.1038/Nature02491  0.483
2004 Alcalde M, Farinas ET, Arnold FH. Colorimetric high-throughput assay for alkene epoxidation catalyzed by cytochrome P450 BM-3 variant 139-3. Journal of Biomolecular Screening. 9: 141-6. PMID 15006137 DOI: 10.1177/1087057103261913  0.375
2004 Umeno D, Arnold FH. Evolution of a pathway to novel long-chain carotenoids. Journal of Bacteriology. 186: 1531-6. PMID 14973014 DOI: 10.1128/Jb.186.5.1531-1536.2004  0.388
2004 Wong TS, Arnold FH, Schwaneberg U. Laboratory evolution of cytochrome p450 BM-3 monooxygenase for organic cosolvents. Biotechnology and Bioengineering. 85: 351-8. PMID 14748091 DOI: 10.1002/Bit.10896  0.579
2004 Farinas ET, Alcalde M, Arnold F. Alkene epoxidation catalyzed by cytochrome P450 BM-3 139-3 Tetrahedron. 60: 525-528. DOI: 10.1016/J.Tet.2003.10.099  0.351
2003 Collins CH, Yokobayashi Y, Umeno D, Arnold FH. Engineering proteins that bind, move, make and break DNA. Current Opinion in Biotechnology. 14: 665. PMID 14662399 DOI: 10.1016/J.Copbio.2003.10.002  0.705
2003 Peters MW, Meinhold P, Glieder A, Arnold FH. Regio- and enantioselective alkane hydroxylation with engineered cytochromes P450 BM-3. Journal of the American Chemical Society. 125: 13442-50. PMID 14583039 DOI: 10.1021/Ja0303790  0.722
2003 Collins CH, Yokobayashi Y, Umeno D, Arnold FH. Engineering proteins that bind, move, make and break DNA. Current Opinion in Biotechnology. 14: 371-8. PMID 12943845 DOI: 10.1016/S0958-1669(03)00091-0  0.733
2003 Umeno D, Hiraga K, Arnold FH. Method to protect a targeted amino acid residue during random mutagenesis. Nucleic Acids Research. 31: e91. PMID 12907743 DOI: 10.1093/Nar/Gng091  0.332
2003 Cirino PC, Tang Y, Takahashi K, Tirrell DA, Arnold FH. Global incorporation of norleucine in place of methionine in cytochrome P450 BM-3 heme domain increases peroxygenase activity. Biotechnology and Bioengineering. 83: 729-34. PMID 12889037 DOI: 10.1002/Bit.10718  0.427
2003 Meyer MM, Silberg JJ, Voigt CA, Endelman JB, Mayo SL, Wang ZG, Arnold FH. Library analysis of SCHEMA-guided protein recombination. Protein Science : a Publication of the Protein Society. 12: 1686-93. PMID 12876318 DOI: 10.1110/Ps.0306603  0.795
2003 Hiraga K, Arnold FH. General method for sequence-independent site-directed chimeragenesis. Journal of Molecular Biology. 330: 287-96. PMID 12823968 DOI: 10.1016/S0022-2836(03)00590-4  0.362
2003 Umeno D, Arnold FH. A C35 carotenoid biosynthetic pathway. Applied and Environmental Microbiology. 69: 3573-9. PMID 12788765 DOI: 10.1128/Aem.69.6.3573-3579.2003  0.312
2003 Wintrode PL, Zhang D, Vaidehi N, Arnold FH, Goddard WA. Protein dynamics in a family of laboratory evolved thermophilic enzymes. Journal of Molecular Biology. 327: 745-57. PMID 12634066 DOI: 10.1016/S0022-2836(03)00147-5  0.326
2003 Bulter T, Alcalde M, Sieber V, Meinhold P, Schlachtbauer C, Arnold FH. Functional expression of a fungal laccase in Saccharomyces cerevisiae by directed evolution. Applied and Environmental Microbiology. 69: 987-95. PMID 12571021 DOI: 10.1128/Aem.69.2.987-995.2003  0.737
2003 YOKOBAYASHI Y, COLLINS CH, LEADBETTER JR, ARNOLD FH, WEISS R. EVOLUTIONARY DESIGN OF GENETIC CIRCUITS AND CELL-CELL COMMUNICATIONS Advances in Complex Systems. 6: 37-45. DOI: 10.1142/S0219525903000700  0.692
2002 Yokobayashi Y, Weiss R, Arnold FH. Directed evolution of a genetic circuit. Proceedings of the National Academy of Sciences of the United States of America. 99: 16587-91. PMID 12451174 DOI: 10.1073/Pnas.252535999  0.616
2002 Umeno D, Tobias AV, Arnold FH. Evolution of the C30 carotenoid synthase CrtM for function in a C40 pathway. Journal of Bacteriology. 184: 6690-9. PMID 12426357 DOI: 10.1128/Jb.184.23.6690-6699.2002  0.775
2002 Glieder A, Farinas ET, Arnold FH. Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase. Nature Biotechnology. 20: 1135-9. PMID 12368811 DOI: 10.1038/Nbt744  0.397
2002 Sun L, Bulter T, Alcalde M, Petrounia IP, Arnold FH. Modification of galactose oxidase to introduce glucose 6-oxidase activity. Chembiochem : a European Journal of Chemical Biology. 3: 781-3. PMID 12203977 DOI: 10.1002/1439-7633(20020802)3:8<781::Aid-Cbic781>3.0.Co;2-8  0.734
2002 Fu AY, Chou HP, Spence C, Arnold FH, Quake SR. An integrated microfabricated cell sorter. Analytical Chemistry. 74: 2451-7. PMID 12069222 DOI: 10.1021/Ac0255330  0.617
2002 Voigt CA, Martinez C, Wang ZG, Mayo SL, Arnold FH. Protein building blocks preserved by recombination. Nature Structural Biology. 9: 553-8. PMID 12042875 DOI: 10.1038/Nsb805  0.739
2002 Cirino PC, Arnold FH. Protein engineering of oxygenases for biocatalysis. Current Opinion in Chemical Biology. 6: 130-5. PMID 12038995 DOI: 10.1016/S1367-5931(02)00305-8  0.402
2002 Mayer KM, Arnold FH. A colorimetric assay to quantify dehydrogenase activity in crude cell lysates. Journal of Biomolecular Screening. 7: 135-40. PMID 12006112 DOI: 10.1177/108705710200700206  0.362
2002 Joern JM, Meinhold P, Arnold FH. Analysis of shuffled gene libraries. Journal of Molecular Biology. 316: 643-56. PMID 11866523 DOI: 10.1006/Jmbi.2001.5349  0.78
2002 Cirino PC, Arnold FH. Regioselectivity and Activity of Cytochrome P450 BM-3 and Mutant F87A in Reactions Driven by Hydrogen Peroxide Advanced Synthesis and Catalysis. 344: 932-937. DOI: 10.1002/1615-4169(200210)344:9<932::Aid-Adsc932>3.0.Co;2-M  0.411
2001 Farinas ET, Bulter T, Arnold FH. Directed enzyme evolution. Current Opinion in Biotechnology. 12: 545-51. PMID 11849936 DOI: 10.1016/S0958-1669(01)00261-0  0.344
2001 Voigt CA, Mayo SL, Arnold FH, Wang ZG. Computationally focusing the directed evolution of proteins. Journal of Cellular Biochemistry. Supplement. 58-63. PMID 11842429 DOI: 10.1002/Jcb.10066  0.745
2001 Sun L, Petrounia IP, Yagasaki M, Bandara G, Arnold FH. Expression and stabilization of galactose oxidase in Escherichia coli by directed evolution. Protein Engineering. 14: 699-704. PMID 11707617 DOI: 10.1093/Protein/14.9.699  0.75
2001 Joern JM, Sakamoto T, Arisawa A, Arnold FH. A versatile high throughput screen for dioxygenase activity using solid-phase digital imaging. Journal of Biomolecular Screening. 6: 219-23. PMID 11689121 DOI: 10.1177/108705710100600403  0.772
2001 Schwaneberg U, Otey C, Cirino PC, Farinas E, Arnold FH. Cost-effective whole-cell assay for laboratory evolution of hydroxylases in Escherichia coli. Journal of Biomolecular Screening. 6: 111-7. PMID 11689105 DOI: 10.1177/108705710100600207  0.328
2001 Wintrode PL, Miyazaki K, Arnold FH. Patterns of adaptation in a laboratory evolved thermophilic enzyme. Biochimica Et Biophysica Acta. 1549: 1-8. PMID 11566363 DOI: 10.1016/S0167-4838(01)00226-6  0.339
2001 Sakamoto T, Joern JM, Arisawa A, Arnold FH. Laboratory evolution of toluene dioxygenase to accept 4-picoline as a substrate. Applied and Environmental Microbiology. 67: 3882-7. PMID 11525981 DOI: 10.1128/Aem.67.9.3882-3887.2001  0.813
2001 Morawski B, Quan S, Arnold FH. Functional expression and stabilization of horseradish peroxidase by directed evolution in Saccharomyces cerevisiae. Biotechnology and Bioengineering. 76: 99-107. PMID 11505379 DOI: 10.1002/Bit.1149  0.36
2001 Sieber V, Martinez CA, Arnold FH. Libraries of hybrid proteins from distantly related sequences. Nature Biotechnology. 19: 456-60. PMID 11329016 DOI: 10.1038/88129  0.371
2001 Thorsen T, Roberts RW, Arnold FH, Quake SR. Dynamic pattern formation in a vesicle-generating microfluidic device. Physical Review Letters. 86: 4163-6. PMID 11328121 DOI: 10.1103/Physrevlett.86.4163  0.516
2001 Voigt CA, Mayo SL, Arnold FH, Wang ZG. Computational method to reduce the search space for directed protein evolution. Proceedings of the National Academy of Sciences of the United States of America. 98: 3778-83. PMID 11274394 DOI: 10.1073/Pnas.051614498  0.744
2001 Arnold FH. Combinatorial and computational challenges for biocatalyst design. Nature. 409: 253-7. PMID 11196654 DOI: 10.1038/35051731  0.312
2001 Arnold FH, Wintrode PL, Miyazaki K, Gershenson A. How enzymes adapt: lessons from directed evolution. Trends in Biochemical Sciences. 26: 100-6. PMID 11166567 DOI: 10.1016/S0968-0004(00)01755-2  0.367
2001 Thorsen T, Roberts RW, Arnold FH, Quake SR. Dynamic pattern formation in a vesicle-generating microfluidic device Physical Review Letters. 86: 4163-4166. DOI: 10.1103/PhysRevLett.86.4163  0.443
2001 Farinas ET, Schwaneberg U, Glieder A, Arnold FH. Directed Evolution of a Cytochrome P450 Monooxygenase for Alkane Oxidation Advanced Synthesis and Catalysis. 343: 601-606. DOI: 10.1002/1615-4169(200108)343:6/7<601::Aid-Adsc601>3.0.Co;2-9  0.351
2000 Gershenson A, Arnold FH. Enzyme stabilization by directed evolution. Genetic Engineering. 22: 55-76. PMID 11501381 DOI: 10.1007/978-1-4615-4199-8_5  0.421
2000 Volkov AA, Shao Z, Arnold FH. Random chimeragenesis by heteroduplex recombination. Methods in Enzymology. 328: 456-63. PMID 11075360 DOI: 10.1016/S0076-6879(00)28412-7  0.337
2000 Wintrode PL, Arnold FH. Temperature adaptation of enzymes: lessons from laboratory evolution. Advances in Protein Chemistry. 55: 161-225. PMID 11050934 DOI: 10.1016/S0065-3233(01)55004-4  0.373
2000 Petrounia IP, Arnold FH. Designed evolution of enzymatic properties Current Opinion in Biotechnology. 11: 325-330. PMID 10975451 DOI: 10.1016/S0958-1669(00)00107-5  0.415
2000 Lin Z, Thorsen T, Arnold FH. Functional expression of horseradish peroxidase in E. coli By directed evolution Biotechnology Progress. 16: 680. PMID 10933847 DOI: 10.1021/bp990292b  0.483
2000 Wintrode PL, Miyazaki K, Arnold FH. Cold adaptation of a mesophilic subtilisin-like protease by laboratory evolution Journal of Biological Chemistry. 275: 31635-31640. PMID 10906329 DOI: 10.1074/Jbc.M004503200  0.335
2000 Schmidt-Dannert C, Umeno D, Arnold FH. Molecular breeding of carotenoid biosynthetic pathways Nature Biotechnology. 18: 750-753. PMID 10888843 DOI: 10.1038/77319  0.326
2000 Morawski B, Lin Z, Cirino P, Joo H, Bandara G, Arnold FH. Functional expression of horseradish peroxidase in Saccharomyces cerevisiae and Pichia pastoris Protein Engineering. 13: 377-384. PMID 10835112 DOI: 10.1093/Protein/13.5.377  0.377
2000 Gershenson A, Schauerte JA, Giver L, Arnold FH. Tryptophan phosphorescence study of enzyme flexibility and unfolding in laboratory-evolved thermostable esterases Biochemistry. 39: 4658-4665. PMID 10769121 DOI: 10.1021/Bi992473S  0.396
2000 Miyazaki K, Wintrode PL, Grayling RA, Rubingh DN, Arnold FH. Directed evolution study of temperature adaptation in a psychrophilic enzyme Journal of Molecular Biology. 297: 1015-1026. PMID 10736234 DOI: 10.1006/Jmbi.2000.3612  0.363
2000 May O, Nguyen PT, Arnold FH. Inverting enantioselectivity by directed evolution of hydantoinase for improved production of L-methionine Nature Biotechnology. 18: 317-320. PMID 10700149 DOI: 10.1038/73773  0.31
2000 Voight CA, Mayo SL, Wang Z, Arnold FH. Computationally-guided directed evolution Journal of Molecular Graphics and Modelling. 18: 556-557. DOI: 10.1016/S1093-3263(00)80136-9  0.569
1999 Miyazaki K, Arnold FH. Exploring nonnatural evolutionary pathways by saturation mutagenesis: Rapid improvement of protein function Journal of Molecular Evolution. 49: 716-720. PMID 10594172 DOI: 10.1007/Pl00006593  0.377
1999 Michnick SW, Arnold FH. "Itching" for new strategies in protein engineering. Nature Biotechnology. 17: 1159-60. PMID 10585708 DOI: 10.1038/70699  0.351
1999 Gillam EM, Aguinaldo AM, Notley LM, Kim D, Mundkowski RG, Volkov AA, Arnold FH, Soucek P, DeVoss JJ, Guengerich FP. Formation of indigo by recombinant mammalian cytochrome P450. Biochemical and Biophysical Research Communications. 265: 469-72. PMID 10558891 DOI: 10.1006/Bbrc.1999.1702  0.363
1999 Fu AY, Spence C, Scherer A, Arnold FH, Quake SR. A microfabricated fluorescence-activated cell sorter. Nature Biotechnology. 17: 1109-11. PMID 10545919 DOI: 10.1038/15095  0.63
1999 Spiller B, Gershenson A, Arnold FH, Stevens RC. A structural view of evolutionary divergence. Proceedings of the National Academy of Sciences of the United States of America. 96: 12305-10. PMID 10535917 DOI: 10.1073/Pnas.96.22.12305  0.386
1999 Joo H, Arisawa A, Lin Z, Arnold FH. A high-throughput digital imaging screen for the discovery and directed evolution of oxygenases. Chemistry & Biology. 6: 699-706. PMID 10508682 DOI: 10.1016/S1074-5521(00)80017-4  0.377
1999 Arnold FH, Giver L, Gershenson A, Zhao H, Miyazaki K. Directed evolution of mesophilic enzymes into their thermophilic counterparts. Annals of the New York Academy of Sciences. 870: 400-3. PMID 10415508 DOI: 10.1111/J.1749-6632.1999.Tb08913.X  0.473
1999 Joo H, Lin Z, Arnold FH. Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation Nature. 399: 670-673. PMID 10385118 DOI: 10.1038/21395  0.428
1999 Lin Z, Thorsen T, Arnold FH. Functional expression of horseradish peroxidase in E. coli by directed evolution. Biotechnology Progress. 15: 467-71. PMID 10356264 DOI: 10.1021/Bp990037R  0.617
1999 Schmidt-Dannert C, Arnold FH. Directed evolution of industrial enzymes Trends in Biotechnology. 17: 135-136. PMID 10203769 DOI: 10.1016/S0167-7799(98)01283-9  0.363
1999 Zhao H, Arnold FH. Directed evolution converts subtilisin E into a functional equivalent of thermitase. Protein Engineering. 12: 47-53. PMID 10065710 DOI: 10.1093/Protein/12.1.47  0.497
1999 Volkov AA, Shao Z, Arnold FH. Recombination and chimeragenesis by in vitro heteroduplex formation and in vivo repair Nucleic Acids Research. 27: i-vi. DOI: 10.1093/Nar/27.18.E18-I  0.325
1999 Maloney KM, Schief WR, Pack DW, Frey W, Arnold FH, Vogel V. Binding and two-dimensional crystallization of streptavidin at the air/water interface via engineered Cu-IDA chelator lipids Coordination Chemistry Reviews. 183: 3-18. DOI: 10.1016/S0010-8545(98)00174-X  0.579
1998 Giver L, Gershenson A, Freskgard PO, Arnold FH. Directed evolution of a thermostable esterase. Proceedings of the National Academy of Sciences of the United States of America. 95: 12809-13. PMID 9788996 DOI: 10.1073/Pnas.95.22.12809  0.371
1998 Moore JC, Arnold FH. Directed evolution of a para-nitrobenzyl esterase for aqueous-organic solvents. Nature Biotechnology. 14: 458-67. PMID 9630920 DOI: 10.1038/Nbt0496-458  0.439
1998 Zhao H, Giver L, Shao Z, Affholter JA, Arnold FH. Molecular evolution by staggered extension process (StEP) in vitro recombination. Nature Biotechnology. 16: 258-61. PMID 9528005 DOI: 10.1038/Nbt0398-258  0.604
1998 Arnold FH. Enzyme engineering reaches the boiling point. Proceedings of the National Academy of Sciences of the United States of America. 95: 2035-6. PMID 9482832 DOI: 10.1073/Pnas.95.5.2035  0.377
1998 Shao Z, Zhao H, Giver L, Arnold FH. Random-priming in vitro recombination: an effective tool for directed evolution. Nucleic Acids Research. 26: 681-3. PMID 9421535 DOI: 10.1093/Nar/26.2.681  0.62
1998 Kuchner O, Arnold FH. Directed evolution of enzyme catalysts. Trends in Biotechnology. 15: 523-30. PMID 9418307 DOI: 10.1016/S0167-7799(97)01138-4  0.41
1998 Arnold FH. Design by Directed Evolution Accounts of Chemical Research. 31: 125-131. DOI: 10.1021/Ar960017F  0.396
1997 Moore JC, Jin HM, Kuchner O, Arnold FH. Strategies for the in vitro evolution of protein function: enzyme evolution by random recombination of improved sequences. Journal of Molecular Biology. 272: 336-47. PMID 9325094 DOI: 10.1006/Jmbi.1997.1252  0.381
1997 Zhao H, Arnold FH. Combinatorial protein design: strategies for screening protein libraries. Current Opinion in Structural Biology. 7: 480-5. PMID 9266168 DOI: 10.1016/S0959-440X(97)80110-8  0.428
1997 Zhao H, Arnold FH. Functional and nonfunctional mutations distinguished by random recombination of homologous genes. Proceedings of the National Academy of Sciences of the United States of America. 94: 7997-8000. PMID 9223302 DOI: 10.1073/Pnas.94.15.7997  0.421
1997 Pack DW, Arnold FH. Langmuir monolayer characterization of metal chelating lipids for protein targeting to membranes Chemistry and Physics of Lipids. 86: 135-152. PMID 9179995 DOI: 10.1016/S0009-3084(97)02662-5  0.566
1997 Arnold FH, Moore JC. Optimizing industrial enzymes by directed evolution. Advances in Biochemical Engineering/Biotechnology. 58: 1-14. PMID 9103909 DOI: 10.1007/Bfb0103300  0.44
1997 Chen G, Guan Z, Chen CT, Fu L, Sundaresan V, Arnold FH. A glucose-sensing polymer. Nature Biotechnology. 15: 354-7. PMID 9094137 DOI: 10.1038/Nbt0497-354  0.433
1997 Zhao H, Arnold FH. Optimization of DNA shuffling for high fidelity recombination. Nucleic Acids Research. 25: 1307-8. PMID 9092645 DOI: 10.1093/Nar/25.6.1307  0.406
1997 Pack DW, Chen G, Maloney KM, Chen CT, Arnold FH. A metal-chelating lipid for 2D protein crystallization via coordination of surface histidines Journal of the American Chemical Society. 119: 2479-2487. DOI: 10.1021/Ja964099E  0.584
1997 Pack DW, Ng K, Maloney KM, Arnold FH. Ligand-induced reorganization and assembly in synthetic lipid membranes Supramolecular Science. 4: 3-10. DOI: 10.1016/S0968-5677(96)00045-4  0.574
1996 You L, Arnold FH. Directed evolution of subtilisin E in Bacillus subtilis to enhance total activity in aqueous dimethylformamide Protein Engineering. 9: 77-83. PMID 9053906 DOI: 10.1093/Protein/9.1.77  0.365
1996 Zhao H, Li Y, Arnold FH. Strategy for the directed evolution of a peptide ligase. Annals of the New York Academy of Sciences. 799: 1-5. PMID 8958065 DOI: 10.1111/J.1749-6632.1996.Tb33169.X  0.354
1996 Shao Z, Arnold FH. Engineering new functions and altering existing functions. Current Opinion in Structural Biology. 6: 513-8. PMID 8794158 DOI: 10.1016/S0959-440X(96)80117-5  0.403
1996 Frey W, Schief WR, Pack DW, Chen CT, Chilkoti A, Stayton P, Vogel V, Arnold FH. Two-dimensional protein crystallization via metal-ion coordination by naturally occurring surface histidines Proceedings of the National Academy of Sciences of the United States of America. 93: 4937-4941. PMID 8643507 DOI: 10.1073/Pnas.93.10.4937  0.584
1996 Arnold FH. Directed evolution: Creating biocatalysts for the future Chemical Engineering Science. 51: 5091-5102. DOI: 10.1016/S0009-2509(96)00288-6  0.409
1995 Ng K, Pack DW, Sasaki DY, Arnold FH. Engineering protein-lipid interactions: Targeting of histidine-tagged proteins to metal-chelating lipid monolayers Langmuir. 11: 4048-4055. DOI: 10.1021/La00010A069  0.591
1995 Sasaki DY, Shnek DR, Pack DW, Arnold FH. Metal-induced dispersion of lipid aggregates: A simple, selective, and sensitive fluorescent metal ion sensor Angewandte Chemie (International Edition in English). 34: 905-907. DOI: 10.1002/Anie.199509051  0.545
1995 Sasaki DY, Shnek DR, Pack DW, Arnold FH. Metall-induzierte Dispersion von Lipid-Aggregaten; ein einfacher, selektiver und empfindlicher Fluoreszenzsensor für Metall-Ionen Angewandte Chemie. 107: 994-996. DOI: 10.1002/Ange.19951070819  0.534
1994 Todd RJ, Johnson RD, Arnold FH. Multiple-site binding interactions in metal-affinity chromatography. I. Equilibrium binding of engineered histidine-containing cytochromes c. Journal of Chromatography. A. 662: 13-26. PMID 8136917 DOI: 10.1016/0021-9673(94)85291-X  0.306
1994 Shnek DR, Pack DW, Sasaki DY, Arnold FH. Specific protein attachment to artificial membranes via coordination to lipid-bound copper(II) Langmuir. 10: 2382-2388. DOI: 10.1021/La00019A058  0.566
1993 Chen K, Arnold FH. Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide. Proceedings of the National Academy of Sciences of the United States of America. 90: 5618-22. PMID 8516309 DOI: 10.1073/Pnas.90.12.5618  0.499
1993 Arnold FH. Engineering proteins for nonnatural environments. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 7: 744-9. PMID 8330682 DOI: 10.1096/Fasebj.7.9.8330682  0.417
1993 Arnold FH. Protein engineering for unusual environments. Current Opinion in Biotechnology. 4: 450-5. PMID 7763976 DOI: 10.1016/0958-1669(93)90011-K  0.382
1993 Arnold FH. Engineering enzymes for nonnatural environments: Improved biocatalysts for the chemical and biotechnology industries Protein Engineering Design & Selection. 6: 59-59. DOI: 10.1093/Protein/6.Supplement.59  0.342
1993 Muheim A, Todd RJ, Casimiro DR, Gray HB, Arnold FH. Ruthenium-mediated protein cross-linking and stabilization Journal of the American Chemical Society. 115: 5312-5313. DOI: 10.1021/Ja00065A060  0.404
1993 Casimiro DR, Muheim A, Richards JH, Arnold FH, Winkler JR, Gray HB. Electron transfer in cytochromes C with chelated ruthenium(II) polypyridine complexes. Journal of Inorganic Biochemistry. 51: 232. DOI: 10.1016/0162-0134(93)85266-B  0.385
1992 Economou C, Chen K, Arnold FH. Random mutagenesis to enhance the activity of subtilisin in organic solvents: Characterization of Q103R subtilisin E. Biotechnology and Bioengineering. 39: 658-62. PMID 18600995 DOI: 10.1002/Bit.260390610  0.478
1992 Martinez P, Van Dam ME, Robinson AC, Chen K, Arnold FH. Stabilization of substilisin E in organic solvents by site-directed mutagenesis. Biotechnology and Bioengineering. 39: 141-7. PMID 18600924 DOI: 10.1002/Bit.260390204  0.412
1991 Arnold FH, Haymore BL. Engineered metal-binding proteins: purification to protein folding. Science (New York, N.Y.). 252: 1796-7. PMID 1648261 DOI: 10.1126/Science.1648261  0.309
1991 Kellis JT, Todd RJ, Arnold FH. Protein stabilization by engineered metal chelation. Nature Biotechnology. 9: 994-995. PMID 1369354 DOI: 10.1038/Nbt1091-994  0.346
1991 Chen KQ, Arnold FH. Enzyme engineering for nonaqueous solvents: random mutagenesis to enhance activity of subtilisin E in polar organic media. Bio/Technology (Nature Publishing Company). 9: 1073-7. PMID 1367624 DOI: 10.1038/Nbt1191-1073  0.478
1991 Chen KQ, Robinson AC, Van Dam ME, Martinez P, Economou C, Arnold FH. Enzyme engineering for nonaqueous solvents. II. Additive effects of mutations on the stability and activity of subtilisin E in polar organic media. Biotechnology Progress. 7: 125-9. PMID 1367168 DOI: 10.1021/Bp00008A007  0.468
1991 Arnold FH. Engineering enzymes for non-aqueous solvents. Trends in Biotechnology. 8: 244-9. PMID 1366732 DOI: 10.1016/0167-7799(90)90186-2  0.396
1989 Arnold FH. Protein design for non-aqueous solvents. Protein Engineering. 2: 21-5. PMID 3253733 DOI: 10.1093/Protein/2.1.21  0.341
1987 Arnold FH, Wolk S, Cruz P, Tinoco I. Structure, dynamics, and thermodynamics of mismatched DNA oligonucleotide duplexes d(CCCAGGG)2 and d(CCCTGGG)2. Biochemistry. 26: 4068-75. PMID 3651437 DOI: 10.1021/Bi00387A049  0.491
1986 Arnold FH, Blanch HW. Analytical affinity chromatography. II. Rate theory and the measurement of biological binding kinetics. Journal of Chromatography. 355: 13-27. PMID 3700540 DOI: 10.1016/S0021-9673(01)97300-5  0.482
1986 Arnold F, Schofield S, Blanch H. Analytical affinity chromatography Journal of Chromatography A. 355: 1-12. DOI: 10.1016/S0021-9673(01)97299-1  0.463
1985 Arnold F, Blanch H, Wilke C. Liquid chromatography plate height equations Journal of Chromatography A. 330: 159-166. DOI: 10.1016/S0021-9673(01)81972-5  0.427
1985 Arnold F, Blanch H, Wilke C. Analysis of affinity separations II: The characterization of affinity columns by pulse techniques The Chemical Engineering Journal. 30: B25-B36. DOI: 10.1016/0300-9467(85)80017-4  0.458
1985 Arnold F, Blanch H, Wilke C. Analysis of affinity separations The Chemical Engineering Journal. 30: B9-B23. DOI: 10.1016/0300-9467(85)80016-2  0.472
1985 Arnold FH, Chalmers JJ, Saunders MS, Croughan MS, Blanch HW, Wilke CR. RATIONAL APPROACH TO THE SCALE-UP OF AFFINITY CHROMATOGRAPHY Acs Symposium Series. 113-122.  0.404
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