Yiguo Hu, Ph.D. - Publications

2007 The University of Maine, Orono, MN, United States 
Biochemistry, Molecular Biology, Oncology

97 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Yin R, Chang J, Li Y, Gao Z, Qiu Q, Wang Q, Han G, Chai J, Feng M, Wang P, Zhang T, Xie X, Hu J, Cheng Y, Guo C, ... ... Hu Y, et al. Differential mA RNA landscapes across hematopoiesis reveal a role for IGF2BP2 in preserving hematopoietic stem cell function. Cell Stem Cell. PMID 34678169 DOI: 10.1016/j.stem.2021.09.014  0.51
2020 Li D, Bledsoe JR, Zeng Y, Liu W, Hu Y, Bi K, Liang A, Li S. A deep learning diagnostic platform for diffuse large B-cell lymphoma with high accuracy across multiple hospitals. Nature Communications. 11: 6004. PMID 33244018 DOI: 10.1038/s41467-020-19817-3  0.453
2016 Li Z, Xing X, Shan F, Li S, Li Z, Xiao A, Xing Z, Xue K, Li Z, Hu Y, Jia Y, Miao R, Zhang L, Bu Z, Wu A, et al. ABCC2-24C > T polymorphism is associated with the response to platinum/5-Fu-based neoadjuvant chemotherapy and better clinical outcomes in advanced gastric cancer patients. Oncotarget. PMID 27487151 DOI: 10.18632/oncotarget.10961  0.465
2016 Han W, Hu Y, Li S, Li F, Tang J. Biohydrogen production in the suspended and attached microbial growth systems from waste pastry hydrolysate. Bioresource Technology. 218: 589-594. PMID 27416509 DOI: 10.1016/j.biortech.2016.07.009  0.418
2016 Cui Y, Li SF, Gu H, Hu YZ, Liang X, Lu CQ, Cai Y, Wang CX, Yang Y, Teng GJ. Disrupted Brain Connectivity Patterns in Patients with Type 2 Diabetes. Ajnr. American Journal of Neuroradiology. PMID 27365332 DOI: 10.3174/ajnr.A4858  0.419
2016 Nan YL, Hu YL, Liu ZK, Duan FF, Xu Y, Li S, Li T, Chen DF, Zeng XY. Relationships between cell cycle pathway gene polymorphisms and risk of hepatocellular carcinoma. World Journal of Gastroenterology. 22: 5558-67. PMID 27350734 DOI: 10.3748/wjg.v22.i24.5558  0.465
2016 Yu JY, Li SZ, Wu LH, Li HM, Gao WH, Zheng YL, Xu N, Liu QG, Li JF, Liu CH, Hu YM, Huang PP. [Preliminary Clinical Efficiency of Autologous Peripheral Blood Mononuclear Cells for Treating Critical Limb Ischemia of Thromboangiitis Obliterans]. Zhongguo Shi Yan Xue Ye Xue Za Zhi / Zhongguo Bing Li Sheng Li Xue Hui = Journal of Experimental Hematology / Chinese Association of Pathophysiology. 24: 892-6. PMID 27342528  0.481
2016 Hu B, Li S, Zhang Z, Xie S, Hu Y, Huang X, Zheng Y. HCV NS4B targets Scribble for proteasome-mediated degradation to facilitate cell transformation. Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine. PMID 27315218 DOI: 10.1007/s13277-016-5100-4  0.478
2016 Lu W, Cao Y, Zhang Y, Li S, Gao J, Wang XA, Mu J, Hu YP, Jiang L, Dong P, Gong W, Liu Y. Up-regulation of PKM2 promote malignancy and related to adverse prognostic risk factor in human gallbladder cancer. Scientific Reports. 6: 26351. PMID 27283076 DOI: 10.1038/srep26351  0.478
2016 Hu YW, Wu SG, Zhao JJ, Ma X, Lu JB, Xiu JC, Zhang Y, Huang C, Qiu YR, Sha YH, Gao JJ, Wang YC, Li SF, Zhao JY, Zheng L, et al. VNN1 Promotes Atherosclerosis Progression in apoE Deficiency Mice Fed a High Fat High Cholesterol Diet. Journal of Lipid Research. PMID 27281478 DOI: 10.1194/jlr.M065565  0.496
2016 Li Y, Si L, Zhai Y, Hu Y, Hu Z, Bei JX, Xie B, Ren Q, Cao P, Yang F, Song Q, Bao Z, Zhang H, Han Y, Wang Z, et al. Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese. Nature Communications. 7: 11664. PMID 27244555 DOI: 10.1038/ncomms11664  0.468
2016 Yang L, Li S, Miao L, Huang H, Liang F, Teng X, Xu L, Wang Q, Xiao W, Ridder WH, Ferguson TA, Chen DF, Kaufman RJ, Hu Y. Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 5891-903. PMID 27225776 DOI: 10.1523/Jneurosci.3709-15.2016  0.454
2016 Liu Z, Li J, Wang L, Li Q, Lu Q, Yu Y, Li S, Bai MY, Hu Y, Xiang F. Repression of callus initiation by the miRNA-directed interaction of auxin-cytokinin in Arabidopsis thaliana. The Plant Journal : For Cell and Molecular Biology. PMID 27189514 DOI: 10.1111/Tpj.13211  0.472
2016 Ji CC, Tang HF, Hu YY, Zhang Y, Zheng MH, Qin HY, Li SZ, Wang XY, Fei Z, Cheng G. Saponin 6 derived from Anemone taipaiensis induces U87 human malignant glioblastoma cell apoptosis via regulation of Fas and Bcl‑2 family proteins. Molecular Medicine Reports. PMID 27175997 DOI: 10.3892/mmr.2016.5287  0.53
2016 Zhang L, Lu L, Li S, Zhang G, Ouyang L, Robinson K, Tang Y, Zhu Q, Li D, Hu Y, Liu Y. 1,25-Dihydroxyvitamin-D3 Induces Avian β-Defensin Gene Expression in Chickens. Plos One. 11: e0154546. PMID 27135828 DOI: 10.1371/Journal.Pone.0154546  0.469
2016 Wu C, Tian J, Li S, Wu T, Hu Y, Chen S, Sugawara T, Ye X. Structural properties of films and rheology of film-forming solutions of chitosan gallate for food packaging. Carbohydrate Polymers. 146: 10-9. PMID 27112845 DOI: 10.1016/J.Carbpol.2016.03.027  0.425
2016 Yu J, Hu Y, Xue M, Dun Y, Li S, Peng N, Liang Y, Zhao S. Purification and identification of antioxidant peptides from enzymatic hydrolysate of Spirulina platensis. Journal of Microbiology and Biotechnology. PMID 27090190 DOI: 10.4014/jmb.1601.01033  0.425
2016 Li SL, Duo LN, Wang HJ, Dai W, Zhou EH, Xu YN, Zhao T, Xiao YY, Xia L, Yang ZH, Zheng LT, Hu YY, Lin ZM, Wang HN, Gao TW, et al. Identification of the LCK mutation in an atypical epidermodysplasia verruciformis family with T cell defects and virus-induced squamous cell carcinoma. The British Journal of Dermatology. PMID 27087313 DOI: 10.1111/bjd.14679  0.46
2016 Lu HZ, Song L, Liu WY, Xu XL, Hu YH, Shi XM, Li S, Ma WZ, Chang YF, Fan ZX, Lu SG, Wu Y, Yu FH. Survival and Growth of Epiphytic Ferns Depend on Resource Sharing. Frontiers in Plant Science. 7: 416. PMID 27066052 DOI: 10.3389/fpls.2016.00416  0.44
2016 Wu Q, Hu Y, Li S, Peng S, Zhao H. Microbial mechanisms of using enhanced ecological floating beds for eutrophic water improvement. Bioresource Technology. 211: 451-456. PMID 27035477 DOI: 10.1016/j.biortech.2016.03.113  0.424
2016 Ji J, Hu Y, Meng Y, Zhang J, Xu J, Li S, Yang G. The steady flying of a plasmonic flying head over a photoresist-coated surface in a near-field photolithography system. Nanotechnology. 27: 185303. PMID 27010406 DOI: 10.1088/0957-4484/27/18/185303  0.425
2016 Liang HB, Li HH, Hu Y, Li SH, Lü LX, Song XQ. [Effects of Topiramate for atypical antipsychotic-induced body weight gain and metabolic adversities: a systematic review and meta-analysis]. Zhonghua Yi Xue Za Zhi. 96: 216-23. PMID 26879726  0.434
2016 Jiao Y, Zhang X, Wang C, Li L, Liu J, Bar KJ, Wei H, Hu Y, Huang P, Zeng Z, Jiang S, Du J, Shao Y, Metzger D, Li S, et al. Hepatitis C Virus Subtype and Evolution Characteristic Among Drug Users, Men Who Have Sex With Men, and the General Population in Beijing, China. Medicine. 95: e2688. PMID 26871798 DOI: 10.1097/MD.0000000000002688  0.441
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... Hu YC, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.473
2016 Wen W, Kato N, Hwang JY, Guo X, Tabara Y, Li H, Dorajoo R, Yang X, Tsai FJ, Li S, Wu Y, Wu T, Kim S, Guo X, Liang J, ... ... Hu Y, et al. Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference. Scientific Reports. 6: 17958. PMID 26785701 DOI: 10.1038/Srep17958  0.45
2016 Li Y, Hu Y, Dong C, Lu H, Zhang C, Hu Q, Li S, Qin H, Li Z, Wang Y. Vimentin-Mediated Steroidogenesis Induced by Phthalate Esters: Involvement of DNA Demethylation and Nuclear Factor κB. Plos One. 11: e0146138. PMID 26745512 DOI: 10.1371/journal.pone.0146138  0.506
2016 Zheng Y, Wang C, Zhang H, Shao C, Gao LH, Li SS, Yu WJ, He JW, Fu WZ, Hu YQ, Li M, Liu YJ, Zhang ZL. Polymorphisms in Wnt signaling pathway genes are associated with peak bone mineral density, lean mass, and fat mass in Chinese male nuclear families. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation For Osteoporosis and the National Osteoporosis Foundation of the Usa. PMID 26733379 DOI: 10.1007/s00198-015-3457-7  0.458
2016 Simoes RDM, Matthews GM, Hu Y, Glassner B, Bariteau MA, Sheffer M, Shirasaki R, Mitsiades CS. Integrated Evaluation of Results from Genome-Wide Association Studies and Crispr/Cas9-Based Functional Genomics in Myeloma: Implications for Cell-Autonomous Vs. Non-Autonomous Role of Candidate Genes in Myeloma Pathophysiology Blood. 128: 486-486. DOI: 10.1182/Blood.V128.22.486.486  0.347
2016 Matthews GM, De Matos Simoes R, Hu Y, Sheffer M, Dhimolea E, Hengeveld PJ, Bariteau MA, Glassner B, Sievers Q, Ebert BL, Gandolfi S, Awate P, Tang H, Vazquez F, Culhane A, et al. Characterization of Lineage Vs. Context-Dependent Essential Genes in Multiple Myeloma Using Crispr/Cas9 Genome Editing Blood. 128: 119-119. DOI: 10.1182/Blood.V128.22.119.119  0.358
2016 Matthews GM, Gandolfi S, Bruggentheis J, De Matos Simoes R, Buckley DL, Hu Y, Sheffer M, Poarch H, Bradner JE, Mitsiades CS. BET Bromodomain Degradation As a Therapeutic Strategy in Multiple Myeloma Blood. 128: 1062-1062. DOI: 10.1182/Blood.V128.22.1062.1062  0.376
2016 Matthews GM, Hu Y, Sheffer M, Hengeveld PJ, Buckley DL, Bariteau MA, Poarch H, Bradner JE, Mitsiades CS. Abstract 4713: BET bromodomain degradation as a therapeutic strategy in drug-resistant multiple myeloma Cancer Research. 76: 4713-4713. DOI: 10.1158/1538-7445.Am2016-4713  0.348
2015 Yan Z, Huang W, Li S, Zhang W, Hu Y, Liu Chunjing. [Impact of huolong moxibustion on TNF-α and pain degree in the patients of discogenic low back pain]. Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion. 35: 1121-3. PMID 26939323  0.413
2015 Wu Y, Li S, Liu K, Tang X, Fang K, Li N, Li J, Wu T, Chen D, Hu Y. [Study on the association between leukotriene A4 hydrolase gene polymorphism and ischemic stroke]. Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi. 36: 786-9. PMID 26714527  0.433
2015 Hu Y, Li S, Li G, Xiang L, Zhang Q, Jiang X, Liu J. [Research for the antiapoptotic mechanisms of bone marrow mesenchymal stem cells in the treatment of brain ischemia stroke]. Zhonghua Yi Xue Za Zhi. 95: 2382-6. PMID 26711076  0.512
2015 Guo S, Hu Y, Ding Y, Liu J, Zhang M, Ma R, Guo H, Wang K, He J, Yan Y, Rui D, Sun F, Mu L, Niu Q, Zhang J, et al. Association between Eight Functional Polymorphisms and Haplotypes in the Cholesterol Ester Transfer Protein (CETP) Gene and Dyslipidemia in National Minority Adults in the Far West Region of China. International Journal of Environmental Research and Public Health. 12: 15979-92. PMID 26694435 DOI: 10.3390/ijerph121215036  0.438
2015 Hu Y, Li S. Survival regulation of leukemia stem cells. Cellular and Molecular Life Sciences : Cmls. PMID 26686687 DOI: 10.1007/s00018-015-2108-7  0.527
2015 Ma J, Meng F, Li S, Liu L, Zhao L, Liu Y, Hu Y, Li Z, Yao Y, Xi Z, Teng H, Xue Y. Autophagy Induction by Endothelial-Monocyte Activating Polypeptide II Contributes to the Inhibition of Malignant Biological Behaviors by the Combination of EMAP II with Rapamycin in Human Glioblastoma. Frontiers in Molecular Neuroscience. 8: 74. PMID 26648842 DOI: 10.3389/fnmol.2015.00074  0.513
2015 Shi J, Zhang J, Li S, Sun J, Teng Y, Wu M, Li J, Li Y, Hu N, Wang H, Hu Y. Epitope-Based Vaccine Target Screening against Highly Pathogenic MERS-CoV: An In Silico Approach Applied to Emerging Infectious Diseases. Plos One. 10: e0144475. PMID 26641892 DOI: 10.1371/journal.pone.0144475  0.47
2015 Li SY, Cheng H, Qiu WX, Liu LH, Chen S, Hu Y, Xie BR, Li B, Zhang XZ. Protease Activable Cell-Penetrating Peptide-Protoporphyrin Conjugate for Targeted Photodynamic Therapy In Vivo. Acs Applied Materials & Interfaces. PMID 26634784 DOI: 10.1021/Acsami.5B08637  0.463
2015 Chen H, Li S, Hu Y, Cai L, Jiang Q, Tong R, Zang Z, Chen G. An Integrated in Silico Method to Discover Novel Rock1 Inhibitors: Multi-Complex-Based Pharmacophore, Molecular Dynamics Simulation and Hybrid Protocol Virtual Screening. Combinatorial Chemistry & High Throughput Screening. PMID 26632439  0.454
2015 Yang X, Li S, Wu K, Hu L, Liu W, Ji T, Hu Y, Xu L, Sun J, Zhang Z, Zhang C. Surgical exploration of 71 free flaps in crisis following head and neck reconstruction. International Journal of Oral and Maxillofacial Surgery. PMID 26616026 DOI: 10.1016/j.ijom.2015.10.024  0.431
2015 Hu YH, Liu JM, Zhang M, Ma RL, Guo H, Wang K, He J, Yan YZ, Rui DS, Sun F, Mu LT, Niu Q, Ding YS, Zhang JY, Li SG, et al. Association between polymorphisms of fat mass and obesity-associated gene and metabolic syndrome in Kazakh adults of Xinjiang, China. Genetics and Molecular Research : Gmr. 14: 14597-14606. PMID 26600519 DOI: 10.4238/2015.November.18.23  0.443
2015 Liu HC, Zhu D, Wang C, Guan H, Li S, Hu C, Chen Z, Hu Y, Lin H, Lian QQ, Ge RS. Effects of Etomidate on the Steroidogenesis of Rat Immature Leydig Cells. Plos One. 10: e0139311. PMID 26555702 DOI: 10.1371/journal.pone.0139311  0.519
2015 Liu Y, Liu X, Hu Y, Li S, Peng J, Wang Y. Analyzing nonlinear variations in terrestrial vegetation in China during 1982-2012. Environmental Monitoring and Assessment. 187: 722. PMID 26514805 DOI: 10.1007/s10661-015-4922-7  0.439
2015 Hu Y, Song W, Cirstea D, Lu D, Munshi NC, Anderson KC. CSNK1α1 mediates malignant plasma cell survival. Leukemia. 29: 474-82. PMID 24962017 DOI: 10.1038/Leu.2014.202  0.403
2015 Dhimolea E, King E, Sheffer M, Hu Y, Awate PP, Sarkar S, Matthews GM, Murnane M, Bariteau MA, Aftab BT, Mitsiades CS. Constitutive Vs. Stroma-Induced Kinase Dependencies in Myeloma Cells: Functional Mapping Using Small Molecule Inhibitors As Chemical Probes Blood. 126: 3709-3709. DOI: 10.1182/Blood.V126.23.3709.3709  0.406
2015 Hengeveld PJ, Matthews GM, Hu Y, Sheffer M, Bariteau MA, Poarch HI, Dhimolea E, Mitsiades CS. Systematic Evaluation of Preclinical Genetically Determined Vs. Stochastic/Transient Resistance to High-Dose Melphalan Treatment in Multiple Myeloma Blood. 126: 2484-2484. DOI: 10.1182/Blood.V126.23.2484.2484  0.374
2015 Dhimolea E, King E, Rogulin V, Awate PP, Sheffer M, Hu Y, Sarkar S, Murnane M, Bariteau MA, Aftab B, Mitsiades CS. Functional mapping of multiple myeloma kinome with library of small molecule inhibitors Clinical Lymphoma, Myeloma & Leukemia. 15. DOI: 10.1016/J.Clml.2015.07.207  0.381
2014 Cirstea D, Santo L, Hideshima T, Eda H, Mishima Y, Nemani N, Mahindra A, Yee A, Gorgun G, Hu Y, Ohguchi H, Suzuki R, Cottini F, Guichard SM, Anderson KC, et al. Delineating the mTOR kinase pathway using a dual TORC1/2 inhibitor, AZD8055, in multiple myeloma. Molecular Cancer Therapeutics. 13: 2489-500. PMID 25172964 DOI: 10.1158/1535-7163.Mct-14-0147  0.389
2014 Tian Z, D'Arcy P, Wang X, Ray A, Tai YT, Hu Y, Carrasco RD, Richardson P, Linder S, Chauhan D, Anderson KC. A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance. Blood. 123: 706-16. PMID 24319254 DOI: 10.1182/Blood-2013-05-500033  0.39
2014 Minami J, Suzuki R, Mazitschek R, Gorgun G, Ghosh B, Cirstea D, Hu Y, Mimura N, Ohguchi H, Cottini F, Jakubikova J, Munshi NC, Haggarty SJ, Richardson PG, Hideshima T, et al. Histone deacetylase 3 as a novel therapeutic target in multiple myeloma. Leukemia. 28: 680-9. PMID 23913134 DOI: 10.1038/Leu.2013.231  0.351
2014 Song W, Zhang C, Hu Y, Gkotzamanidou M, Shah P, Shan W, Yang G, Li Y, Sperling A, Rashid N, Samur MK, Amin SB, Tai Y, Hideshima T, Parmigiani G, et al. Bone Marrow Microenvironment Regulates Alternative Splicing Events in Myeloma Cells through Downregulation of RNA Binding Protein Fox2 Blood. 124: 4714-4714. DOI: 10.1182/Blood.V124.21.4714.4714  0.367
2014 Dhimolea E, King E, Sheffer M, Hu Y, Sarkar S, Murnane M, Bariteau MA, Aftab BT, Mitsiades CS. Functional Mapping of Multiple Myeloma Kinome Using a Small Molecule Inhibitor Library Blood. 124: 3642-3642. DOI: 10.1182/Blood.V124.21.3642.3642  0.367
2014 Dhimolea E, King E, Kastritis E, McMillin DW, Delmore JE, Negri JM, Jacobs HM, Hayes CA, Sheffer M, Hu Y, Sarkar S, Groen RWJ, Bariteau MA, Aftab BT, Mitsiades CS. Temporal Dynamics of Tumor-Microenvironment Interaction and Treatment Responses Revealed through Time-Lapse Compartment-Specific Bioluminescence Imaging: Translational implications Blood. 124: 276-276. DOI: 10.1182/Blood.V124.21.276.276  0.333
2014 Sheffer M, Hu Y, Shalem O, Sanjana N, Dhimolea E, Sarkar S, Bariteau MA, Aftab BT, Groen RWJ, Zhang F, Mitsiades CS. Genome-Scale Crispr-Cas9 Knockout Studies Reveal Mutifactorial and Functionally Overlapping Mechanisms of Myeloma Cell Resistance to Proteasome Inhibition Blood. 124: 273-273. DOI: 10.1182/Blood.V124.21.273.273  0.337
2013 Hu Y, Zheng M, Gali R, Tian Z, Topal Görgün G, Munshi NC, Mitsiades CS, Anderson KC. A novel rapid-onset high-penetrance plasmacytoma mouse model driven by deregulation of cMYC cooperating with KRAS12V in BALB/c mice. Blood Cancer Journal. 3: e156. PMID 24185503 DOI: 10.1038/Bcj.2013.53  0.403
2013 Cirstea D, Hideshima T, Santo L, Eda H, Mishima Y, Nemani N, Hu Y, Mimura N, Cottini F, Gorgun G, Ohguchi H, Suzuki R, Loferer H, Munshi NC, Anderson KC, et al. Small-molecule multi-targeted kinase inhibitor RGB-286638 triggers P53-dependent and -independent anti-multiple myeloma activity through inhibition of transcriptional CDKs. Leukemia. 27: 2366-75. PMID 23807770 DOI: 10.1038/Leu.2013.194  0.302
2013 Zhang C, Hu Y, Gkotzamanidou M, Shah P, Shan W, Yang G, Amin SB, Tai Y, Li Y, Sperling A, Rashid N, Magrangeas F, Minvielle S, Avet-Loiseau H, Anderson KC, et al. Bone Marrow Microenvironment Affects The Pathogenesis Of Multiple Myeloma Through Downregulation Of Alternative Splicing Factor Fox2 In Myeloma Cells Blood. 122: 3085-3085. DOI: 10.1182/Blood.V122.21.3085.3085  0.384
2012 Tian Z, Zhao JJ, Tai YT, Amin SB, Hu Y, Berger AJ, Richardson P, Chauhan D, Anderson KC. Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells. Blood. 120: 3958-67. PMID 22983447 DOI: 10.1182/Blood-2012-01-401794  0.362
2012 Zhang H, Peng C, Hu Y, Li H, Sheng Z, Chen Y, Sullivan C, Cerny J, Hutchinson L, Higgins A, Miron P, Zhang X, Brehm MA, Li D, Green MR, et al. The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells. Nature Genetics. 44: 861-71. PMID 22797726 DOI: 10.1038/Ng.2350  0.607
2012 Tai YT, Chang BY, Kong SY, Fulciniti M, Yang G, Calle Y, Hu Y, Lin J, Zhao JJ, Cagnetta A, Cea M, Sellitto MA, Zhong MY, Wang Q, Acharya C, et al. Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma. Blood. 120: 1877-87. PMID 22689860 DOI: 10.1182/Blood-2011-12-396853  0.418
2012 Mimura N, Fulciniti M, Gorgun G, Tai YT, Cirstea D, Santo L, Hu Y, Fabre C, Minami J, Ohguchi H, Kiziltepe T, Ikeda H, Kawano Y, French M, Blumenthal M, et al. Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma. Blood. 119: 5772-81. PMID 22538852 DOI: 10.1182/Blood-2011-07-366633  0.359
2012 Cirstea D, Hideshima T, Santo L, Eda H, Scullen TA, Nemani N, Mahindra A, Yee A, Hu Y, Mimura N, Minami J, Ohguchi H, Suzuki R, Cottini F, Guichard SM, et al. Rational Combination Treatment of a Novel Selective mTOR Kinase Inhibitor AZD8055 with IGF-1R Inhibitors in Multiple Myeloma Blood. 120: 4023-4023. DOI: 10.1182/Blood.V120.21.4023.4023  0.351
2012 Tai Y, Landesman Y, Acharya C, Zhong MY, Calle Y, Cea M, Hu Y, Cagnetta A, Tannenbaum D, Chen M, Munshi A, Senapedis W, Saint-Martin J, Kashyap T, Ying H, et al. CRM1 Blockade by Novel Inhibitors of Nuclear Export (SINEs) Inhibits Multiple Myeloma Cell Growth, Osteoclastogenesis, and Myeloma-Induced Osteolysis Blood. 120: 326-326. DOI: 10.1182/Blood.V120.21.326.326  0.409
2012 Tai Y, Chang B, Kong S, Fulciniti M, Yang G, Calle Y, Hu Y, Lin J, Zhao J, Cagnetta A, Cea M, Sellitto M, Chen M, Carrasco DR, Elias L, et al. Abstract 2934: Targeting Bruton's tyrosine kinase with PCI-32765 blocks growth and survival of multiple myeloma and Waldenström macroglobulinemia via potent inhibition of osteoclastogenesis, cytokines/chemokine secretion, and myeloma stem-like cells in the bone marrow microenvironment Cancer Research. 72: 2934-2934. DOI: 10.1158/1538-7445.Am2012-2934  0.416
2011 Sullivan C, Chen Y, Shan Y, Hu Y, Peng C, Zhang H, Kong L, Li S. Functional ramifications for the loss of P-selectin expression on hematopoietic and leukemic stem cells. Plos One. 6: e26246. PMID 22039451 DOI: 10.1371/Journal.Pone.0026246  0.59
2011 Chen Y, Sullivan C, Peng C, Shan Y, Hu Y, Li D, Li S. A tumor suppressor function of the Msr1 gene in leukemia stem cells of chronic myeloid leukemia. Blood. 118: 390-400. PMID 21596859 DOI: 10.1182/Blood-2010-11-316760  0.599
2011 Santo L, Hideshima T, Cirstea D, Bandi M, Nelson EA, Gorgun G, Rodig S, Vallet S, Pozzi S, Patel K, Unitt C, Squires M, Hu Y, Chauhan D, Mahindra A, et al. Antimyeloma activity of a multitargeted kinase inhibitor, AT9283, via potent Aurora kinase and STAT3 inhibition either alone or in combination with lenalidomide. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 3259-71. PMID 21430070 DOI: 10.1158/1078-0432.Ccr-10-3012  0.386
2011 Tai Y, Chang BY, Kong S, Fulciniti M, Yang G, Calle Y, Hu Y, Lin J, Zhao J, Cea M, Cagnetta A, Sellitto MA, Chen M, Hunter Z, Carrasco R, et al. Targeting Brouton's Tyrosine Kinase with PCI-32765 Blocks Growth and Survival of Multiple Myeloma and Waldenstrom Macroglobulinemia Via Potent Inhibition of Osteoclastogenesis, Cytokines/Chemokine Secretion, and Myeloma Stem-Like Cells in the Bone Marrow Microenvironment Blood. 118: 883-883. DOI: 10.1182/Blood.V118.21.883.883  0.413
2011 Cirstea D, Hideshima T, Santo L, Eda H, Canavese M, Scullen TA, Mahindra AK, Gorgun G, Hu Y, Mimura N, Fabre C, Minami J, Ohguchi H, Anderson KC, Guichard SM, et al. DEPTOR Is a Regulator of Response to mTOR Kinase Inhibitors in Multiple Myeloma Blood. 118: 2916-2916. DOI: 10.1182/Blood.V118.21.2916.2916  0.372
2011 Fabre C, Mimura N, Bobb K, Gorgun G, Cirstea DD, Hu Y, Minami J, Ohguchi H, Zhang J, Meshulam J, Mitsiades CS, Richardson PG, Hideshima T, Anderson KC. Dual Inhibition of Canonical and Non-Canonical NF-KB Pathway Demonstrates Significant Anti-Tumor Activities in Multiple Myeloma (MM) Blood. 118: 2902-2902. DOI: 10.1182/Blood.V118.21.2902.2902  0.384
2011 Song W, Hu Y, Yang G, Shah PK, Shan W, Tai Y, Li Y, Minvielle S, Avet-Loiseau H, Anderson KC, Li C, Munshi NC. Alternate Splicing Factor Fox2 Affects Growth and Survival of Multiple Myeloma Cells Blood. 118: 1810-1810. DOI: 10.1182/Blood.V118.21.1810.1810  0.394
2011 Gorgun G, Hideshima T, Raje NS, Mimura N, Bradner JE, Cirstea D, Santo L, Tai Y, Sellitto M, Hu Y, Fabre C, Ohguchi H, Minami J, Richardson PG, Munshi NC, et al. Immunomodulatory Effects of Histone Deacetylase 6 Inhibition in Suppressor Immune Cells in Multiple Myeloma Blood. 118: 128-128. DOI: 10.1182/Blood.V118.21.128.128  0.365
2010 Görgün G, Calabrese E, Soydan E, Hideshima T, Perrone G, Bandi M, Cirstea D, Santo L, Hu Y, Tai YT, Nahar S, Mimura N, Fabre C, Raje N, Munshi N, et al. Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma. Blood. 116: 3227-37. PMID 20651070 DOI: 10.1182/Blood-2010-04-279893  0.378
2010 Görgün G, Calabrese E, Hideshima T, Ecsedy J, Perrone G, Mani M, Ikeda H, Bianchi G, Hu Y, Cirstea D, Santo L, Tai YT, Nahar S, Zheng M, Bandi M, et al. A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma. Blood. 115: 5202-13. PMID 20382844 DOI: 10.1182/Blood-2009-12-259523  0.397
2010 Cirstea D, Hideshima T, Santo L, Pozzi S, Vallet S, Patel K, Gorgun G, Hu Y, Guichard SM, Mahindra A, Anderson KC, Raje N. Disruption of DEPTOR/mTORC1/mTORC2 Signaling Cascade Using a Novel Selective mTOR Kinase Inhibitor AZD8055 Results In Growth Arrest and Apoptosis In Multiple Myeloma Cells Blood. 116: 791-791. DOI: 10.1182/Blood.V116.21.791.791  0.411
2010 Mimura N, Hideshima T, Gorgun G, Cirstea D, Santo L, Hu Y, Fabre C, Blumenthal M, Tam V, Kertesz NL, Zeng Q, Patterson JB, Munshi NC, Richardson P, Anderson KC. Targeting IRE1α-XBP1 Pathway Is a Novel Therapeutic Strategy In Multiple Myeloma Blood. 116: 4074-4074. DOI: 10.1182/Blood.V116.21.4074.4074  0.376
2010 Kong S, Nahar S, Li X, Song W, Hu Y, Muchhal U, Desjarlais J, Richardson P, Munshi NC, Anderson KC, Tai Y. Lenalidomide Enhances Multiple Myeloma Cytotoxicity Induced by a Novel Fc Domain-Engineered Anti-HM1.24 Monoclonal Antibody with Augmented NK Cell Degranulation Blood. 116: 4064-4064. DOI: 10.1182/Blood.V116.21.4064.4064  0.358
2010 Gorgun G, Hideshima T, Mimura N, Cirstea D, Santo L, Hu Y, Fabre C, Raje N, Munshi NC, Richardson PG, Anderson KC. Inhibition of Histone Deacetylase 6 Effects on Interaction of Tumor and Immune Cells In Multiple Myeloma Blood. 116: 2996-2996. DOI: 10.1182/Blood.V116.21.2996.2996  0.359
2010 Santo L, Hideshima T, Cirstea D, Bandi ML, Nelson EA, Ikeda H, Vallet S, Pozzi S, Patel K, Gorgun G, Mimura N, Fabre C, Hu Y, Chauhan D, Squires MS, et al. AT9283, a Small Molecule Multi-Targeted Kinase Inhibitor with Potent Activity Against Aurora Kinase and STAT3 In Combination with Lenalidomide Results In Synergistic Anti-Myeloma Activity Blood. 116: 2994-2994. DOI: 10.1182/Blood.V116.21.2994.2994  0.42
2010 Chen Y, Con S, Hu Y, Kong L, Peng C, Li S. Loss of P-Selectin Promotes the Function of Aged Hematopoietic and Leukemic Stem Cells. Blood. 116: 1577-1577. DOI: 10.1182/Blood.V116.21.1577.1577  0.601
2010 Santo L, Hideshima T, Cirstea D, Nelson EA, Bandi ML, Gorgun G, Vallet S, Pozzi S, Patel K, Ikeda H, Perrone G, Hu Y, Chauhan D, Squires M, Munshi NC, et al. Abstract 2530: Antimyeloma activity of a small molecule multi-targeted kinase inhibitor, AT9283, via potent aurora kinase and STAT3 inhibition Cancer Research. 70: 2530-2530. DOI: 10.1158/1538-7445.Am10-2530  0.393
2009 Chen Y, Hu Y, Zhang H, Peng C, Li S. Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia. Nature Genetics. 41: 783-92. PMID 19503090 DOI: 10.1038/Ng.389  0.604
2009 Chen Y, Hu Y, Michaels S, Segal D, Brown D, Li S. Inhibitory effects of omacetaxine on leukemic stem cells and BCR-ABL-induced chronic myeloid leukemia and acute lymphoblastic leukemia in mice. Leukemia. 23: 1446-54. PMID 19322212 DOI: 10.1038/Leu.2009.52  0.615
2009 Cirstea D, Hideshima T, Santo L, Vallet S, Pozzi S, Patel K, Ikeda H, Loferer H, Perrone G, Gorgun G, Hu Y, Munshi NC, Anderson KC, Raje N. Overcoming p53 Loss with a Multi-Targeted Small Molecule Inhibitor in Multiple Myeloma. Blood. 114: 4915-4915. DOI: 10.1182/Blood.V114.22.4915.4915  0.382
2009 Santo L, Hideshima T, Nelson EA, Cirstea D, Bandi M, Ikeda H, Gorgun G, Vallet S, Pozzi S, Perrone G, Patel K, Hu Y, Squires MS, Yule M, Calabrese E, et al. AT9283, a Small Molecule Multi-Targeted Kinase Inhibitor Induces Antimyeloma Activity Via Potent Aurora Kinase and STAT3 Inhibition. Blood. 114: 3833-3833. DOI: 10.1182/Blood.V114.22.3833.3833  0.387
2007 Peng C, Brain J, Hu Y, Goodrich A, Kong L, Grayzel D, Pak R, Read M, Li S. Inhibition of heat shock protein 90 prolongs survival of mice with BCR-ABL-T315I-induced leukemia and suppresses leukemic stem cells. Blood. 110: 678-85. PMID 17395781 DOI: 10.1182/Blood-2006-10-054098  0.596
2007 Chen Y, Hu Y, Michaels S, Brown D, Li S. Inhibitory Effects of Homoharringtonine on Leukemic Stem Cells and BCR-ABL Induced Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia in Mice. Blood. 110: 2912-2912. DOI: 10.1182/Blood.V110.11.2912.2912  0.624
2006 Zaleskas VM, Krause DS, Lazarides K, Patel N, Hu Y, Li S, Van Etten RA. Molecular pathogenesis and therapy of polycythemia induced in mice by JAK2 V617F. Plos One. 1: e18. PMID 17183644 DOI: 10.1371/Journal.Pone.0000018  0.498
2006 Hu Y, Swerdlow S, Duffy TM, Weinmann R, Lee FY, Li S. Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice. Proceedings of the National Academy of Sciences of the United States of America. 103: 16870-5. PMID 17077147 DOI: 10.1073/Pnas.0606509103  0.562
2006 Hu Y, Sproule T, Peng C, Kong L, Goodrich A, Roopenian D, Li S. Immunodominant Minor Histocompatibility Antigen-Specific T Lymphocytes Eradicate BCR-ABL-Induced B-ALL and CML without Causing Graft-Versus-Host Disease in Mice. Blood. 108: 3686-3686. DOI: 10.1182/Blood.V108.11.3686.3686  0.568
2006 Peng C, Brain J, Hu Y, Kong L, Goodrich A, Grayzel D, Pak R, Read M, Li S. Hsp-90 Inhibition Decreases Survival of BCR-ABL T315I Leukemic Stem Cells in Mice. Blood. 108: 2184-2184. DOI: 10.1182/Blood.V108.11.2184.2184  0.619
2006 Peng C, Brain J, Hu Y, Kong L, Grayzel D, Pak R, Read M, Li S. IPI-504, a Novel, Orally Active HSP90 Inhibitor, Prolongs Survival of Mice with BCR-ABL T315I CML and B-ALL. Blood. 108: 2183-2183. DOI: 10.1182/Blood.V108.11.2183.2183  0.607
2006 Kong L, Hu Y, Peng C, Wang Z, Duffy T, Goodrich A, Li S. Increase in Leukemic Stem Cells Is Associated with Acceleration of BCR-ABL-Induced CML in P-Selectin-Deficient Mice. Blood. 108: 2129-2129. DOI: 10.1182/Blood.V108.11.2129.2129  0.587
2005 Hu Y, Kong L, Staples K, Mills K, Monroe JG, Li S. A Critical Role of Blockade of Cell Differentiation in BCR-ABL-Induced B-Cell Acute Lymphoblastic Leukemia (B-ALL): Basis for Superb Therapeutic Effect on B-ALL in Mice by Promotion of Pro-B Leukemic Cell Differentiation and Treatment with Imatinib. Blood. 106: 844-844. DOI: 10.1182/Blood.V106.11.844.844  0.575
2004 Pelletier SD, Hong DS, Hu Y, Liu Y, Li S. Lack of the adhesion molecules P-selectin and intercellular adhesion molecule-1 accelerate the development of BCR/ABL-induced chronic myeloid leukemia-like myeloproliferative disease in mice. Blood. 104: 2163-71. PMID 15213099 DOI: 10.1182/Blood-2003-09-3033  0.542
2004 Hu Y, Liu Y, Pelletier S, Buchdunger E, Warmuth M, Fabbro D, Hallek M, Van Etten RA, Li S. Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia. Nature Genetics. 36: 453-61. PMID 15098032 DOI: 10.1038/Ng1343  0.53
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