Jason Moffat, Ph.D. - Publications

Affiliations: 
2002 University of Toronto, Toronto, ON, Canada 
Area:
Genetics, Molecular Biology, Cell Biology

81 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Mair B, Moffat J, Boone C, Andrews BJ. Genetic interaction networks in cancer cells. Current Opinion in Genetics & Development. 54: 64-72. PMID 30974317 DOI: 10.1016/j.gde.2019.03.002  0.76
2019 Mair B, Tomic J, Masud SN, Tonge P, Weiss A, Usaj M, Tong AHY, Kwan JJ, Brown KR, Titus E, Atkins M, Chan KSK, Munsie L, Habsid A, Han H, ... ... Moffat J, et al. Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies. Cell Reports. 27: 599-615.e12. PMID 30970261 DOI: 10.1016/j.celrep.2019.02.041  0.76
2019 Costanzo M, Kuzmin E, van Leeuwen J, Mair B, Moffat J, Boone C, Andrews B. Global Genetic Networks and the Genotype-to-Phenotype Relationship. Cell. 177: 85-100. PMID 30901552 DOI: 10.1016/j.cell.2019.01.033  0.96
2019 Pascoe N, Seetharaman A, Teyra J, Manczyk N, Satori MA, Tjandra D, Makhnevych T, Schwerdtfeger C, Brasher BB, Moffat J, Costanzo M, Boone C, Sicheri F, Sidhu S. Yeast Two-Hybrid Analysis for Ubiquitin-Variant Inhibitors of Human Deubiquitinases. Journal of Molecular Biology. PMID 30763569 DOI: 10.1016/j.jmb.2019.02.007  0.76
2019 Nixon AML, Duque A, Yelle N, McLaughlin M, Davoudi S, Pedley NM, Haynes J, Brown KR, Pan J, Hart T, Gilbert PM, Singh SK, O'Brien CA, Sidhu SS, Moffat J. A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations. Scientific Reports. 9: 842. PMID 30696911 DOI: 10.1038/s41598-018-37462-1  0.36
2018 Tanaka M, Fine JH, Kirkham CL, Aguilar OA, Belcheva A, Martin A, Ketela T, Moffat J, Allan DS, Carlyle JR. The inhibitory NKR-P1B:Clr-b recognition axis facilitates detection of oncogenic transformation and cancer immunosurveillance. Cancer Research. PMID 29691253 DOI: 10.1158/0008-5472.CAN-17-1688  0.64
2017 Hart T, Tong AHY, Chan K, Van Leeuwen J, Seetharaman A, Aregger M, Chandrashekhar M, Hustedt N, Seth S, Noonan A, Habsid A, Sizova O, Nedyalkova L, Climie R, Tworzyanski L, ... ... Moffat J, et al. Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens. G3 (Bethesda, Md.). PMID 28655737 DOI: 10.1534/g3.117.041277  0.76
2017 Zipin-Roitman A, Aqaqe N, Yassin M, Biechonski S, Amar M, van Delft MF, Gan OI, McDermott SP, Buzina A, Ketela T, Shlush L, Xie S, Voisin V, Moffat J, Minden MD, et al. SMYD2 lysine methyltransferase regulates leukemia cell growth and regeneration after genotoxic stress. Oncotarget. PMID 28187429 DOI: 10.18632/oncotarget.15147  0.64
2016 Ramachandran S, Haddad D, Li C, Le MX, Ling AK, So CC, Nepal RM, Gommerman JL, Yu K, Ketela T, Moffat J, Martin A. The SAGA Deubiquitination Module Promotes DNA Repair and Class Switch Recombination through ATM and DNAPK-Mediated γH2AX Formation. Cell Reports. PMID 27160905 DOI: 10.1016/j.celrep.2016.04.041  0.64
2016 Nim S, Jeon J, Corbi-Verge C, Seo MH, Ivarsson Y, Moffat J, Tarasova N, Kim PM. Pooled screening for antiproliferative inhibitors of protein-protein interactions. Nature Chemical Biology. PMID 26900867 DOI: 10.1038/nchembio.2026  0.64
2016 Chang Q, Chandrashekhar M, Ketela T, Fedyshyn Y, Moffat J, Hedley D. Cytokinetic effects of Wee1 disruption in pancreatic cancer. Cell Cycle (Georgetown, Tex.). 0. PMID 26890070 DOI: 10.1080/15384101.2016.1138188  0.64
2016 Harris EA, Koh EJ, Moffat J, McMillen DR. Automated inference procedure for the determination of cell growth parameters. Physical Review. E. 93: 012402. PMID 26871096 DOI: 10.1103/PhysRevE.93.012402  0.64
2015 Gupta GD, Coyaud É, Gonçalves J, Mojarad BA, Liu Y, Wu Q, Gheiratmand L, Comartin D, Tkach JM, Cheung SW, Bashkurov M, Hasegan M, Knight JD, Lin ZY, Schueler M, ... ... Moffat J, et al. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. Cell. 163: 1484-99. PMID 26638075 DOI: 10.1016/j.cell.2015.10.065  0.64
2015 Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, MacLeod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Mero P, Dirks P, Sidhu S, Roth FP, Rissland OS, ... ... Moffat J, et al. High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities. Cell. PMID 26627737 DOI: 10.1016/j.cell.2015.11.015  0.64
2015 Bailey ML, Singh T, Mero P, Moffat J, Hieter P. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. Genetics. 201: 885-95. PMID 26354767 DOI: 10.1534/genetics.115.180653  0.64
2015 Pandyra AA, Mullen PJ, Goard CA, Ericson E, Sharma P, Kalkat M, Yu R, Pong JT, Brown KR, Hart T, Gebbia M, Lang KS, Giaever G, Nislow C, Moffat J, et al. Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death. Oncotarget. PMID 26353928 DOI: 10.18632/oncotarget.4817  0.64
2015 Hunter FW, Young RJ, Shalev Z, Vellanki RN, Wang J, Gu Y, Joshi N, Sreebhavan S, Weinreb I, Goldstein DP, Moffat J, Ketela T, Brown KR, Koritzinsky M, Solomon B, et al. Identification of P450 Oxidoreductase as a Major Determinant of Sensitivity to Hypoxia-Activated Prodrugs. Cancer Research. PMID 26297733 DOI: 10.1158/0008-5472.CAN-15-1107  0.64
2015 Hornsby M, Paduch M, Miersch S, Sääf A, Matsuguchi T, Lee B, Wypisniak K, Doak A, King D, Usatyuk S, Perry K, Lu V, Thomas W, Luke J, Goodman J, ... ... Moffat J, et al. A High Through-put Platform for Recombinant Antibodies to Folded Proteins. Molecular & Cellular Proteomics : McP. PMID 26290498 DOI: 10.1074/mcp.O115.052209  0.64
2015 Gaudet RG, Sintsova A, Buckwalter CM, Leung N, Cochrane A, Li J, Cox AD, Moffat J, Gray-Owen SD. INNATE IMMUNITY. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity. Science (New York, N.Y.). 348: 1251-5. PMID 26068852 DOI: 10.1126/science.aaa4921  0.64
2015 Cole A, Wang Z, Coyaud E, Voisin V, Gronda M, Jitkova Y, Mattson R, Hurren R, Babovic S, Maclean N, Restall I, Wang X, Jeyaraju DV, Sukhai MA, Prabha S, ... ... Moffat J, et al. Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia. Cancer Cell. 27: 864-76. PMID 26058080 DOI: 10.1016/j.ccell.2015.05.004  0.64
2015 Koh JL, Chong YT, Friesen H, Moses A, Boone C, Andrews BJ, Moffat J. CYCLoPs: A Comprehensive Database Constructed from Automated Analysis of Protein Abundance and Subcellular Localization Patterns in Saccharomyces cerevisiae. G3 (Bethesda, Md.). 5: 1223-32. PMID 26048563 DOI: 10.1534/g3.115.017830  0.64
2015 Chong YT, Koh JL, Friesen H, Duffy K, Cox MJ, Moses A, Moffat J, Boone C, Andrews BJ. Yeast Proteome Dynamics from Single Cell Imaging and Automated Analysis. Cell. 161: 1413-24. PMID 26046442 DOI: 10.1016/j.cell.2015.04.051  0.64
2015 Trzci?ska-Daneluti AM, Chen A, Nguyen L, Murchie R, Jiang C, Moffat J, Pelletier L, Rotin D. RNA Interference Screen to Identify Kinases That Suppress Rescue of ΔF508-CFTR. Molecular & Cellular Proteomics : McP. 14: 1569-83. PMID 25825526 DOI: 10.1074/mcp.M114.046375  0.64
2015 St-Germain JR, Taylor P, Zhang W, Li Z, Ketela T, Moffat J, Neel BG, Trudel S, Moran MF. Differential regulation of FGFR3 by PTPN1 and PTPN2. Proteomics. 15: 419-33. PMID 25311528 DOI: 10.1002/pmic.201400259  0.64
2014 Hart T, Brown KR, Sircoulomb F, Rottapel R, Moffat J. Measuring error rates in genomic perturbation screens: gold standards for human functional genomics. Molecular Systems Biology. 10: 733. PMID 24987113 DOI: 10.15252/msb.20145216  0.64
2014 Petschnigg J, Groisman B, Kotlyar M, Taipale M, Zheng Y, Kurat CF, Sayad A, Sierra JR, Mattiazzi Usaj M, Snider J, Nachman A, Krykbaeva I, Tsao MS, Moffat J, Pawson T, et al. The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nature Methods. 11: 585-92. PMID 24658140 DOI: 10.1038/nmeth.2895  0.64
2014 Mak AB, Schnegg C, Lai CY, Ghosh S, Yang MH, Moffat J, Hsu MY. CD133-targeted niche-dependent therapy in cancer: a multipronged approach. The American Journal of Pathology. 184: 1256-62. PMID 24589338 DOI: 10.1016/j.ajpath.2014.01.008  0.64
2014 Mak AB, Pehar M, Nixon AM, Williams RA, Uetrecht AC, Puglielli L, Moffat J. Post-translational regulation of CD133 by ATase1/ATase2-mediated lysine acetylation. Journal of Molecular Biology. 426: 2175-82. PMID 24556617 DOI: 10.1016/j.jmb.2014.02.012  0.64
2014 Cullis J, Meiri D, Sandi MJ, Radulovich N, Kent OA, Medrano M, Mokady D, Normand J, Larose J, Marcotte R, Marshall CB, Ikura M, Ketela T, Moffat J, Neel BG, et al. The RhoGEF GEF-H1 is required for oncogenic RAS signaling via KSR-1. Cancer Cell. 25: 181-95. PMID 24525234 DOI: 10.1016/j.ccr.2014.01.025  0.64
2014 Deng T, Liu JC, Chung PE, Uehling D, Aman A, Joseph B, Ketela T, Jiang Z, Schachter NF, Rottapel R, Egan SE, Al-Awar R, Moffat J, Zacksenhaus E. shRNA kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer. Cancer Research. 74: 2119-30. PMID 24487029 DOI: 10.1158/0008-5472.CAN-13-2138  0.64
2013 Vizeacoumar FJ, Arnold R, Vizeacoumar FS, Chandrashekhar M, Buzina A, Young JT, Kwan JH, Sayad A, Mero P, Lawo S, Tanaka H, Brown KR, Baryshnikova A, Mak AB, Fedyshyn Y, ... ... Moffat J, et al. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. Molecular Systems Biology. 9: 696. PMID 24104479 DOI: 10.1038/msb.2013.54  0.64
2013 Owen SC, Patel N, Logie J, Pan G, Persson H, Moffat J, Sidhu SS, Shoichet MS. Targeting HER2+ breast cancer cells: lysosomal accumulation of anti-HER2 antibodies is influenced by antibody binding site and conjugation to polymeric nanoparticles. Journal of Controlled Release : Official Journal of the Controlled Release Society. 172: 395-404. PMID 23880472 DOI: 10.1016/j.jconrel.2013.07.011  0.64
2013 Samuel N, Sayad A, Wilson G, Lemire M, Brown KR, Muthuswamy L, Hudson TJ, Moffat J. Integrated genomic, transcriptomic, and RNA-interference analysis of genes in somatic copy number gains in pancreatic ductal adenocarcinoma. Pancreas. 42: 1016-26. PMID 23851435 DOI: 10.1097/MPA.0b013e318287d043  0.64
2013 Kittanakom S, Arnoldo A, Brown KR, Wallace I, Kunavisarut T, Torti D, Heisler LE, Surendra A, Moffat J, Giaever G, Nislow C. Miniature short hairpin rna screens to characterize antiproliferative drugs G3: Genes, Genomes, Genetics. 3: 1375-1387. PMID 23797109 DOI: 10.1534/g3.113.006437  0.64
2013 Mak AB, Moffat J. RNA interference screens to uncover membrane protein biology. Briefings in Functional Genomics. 12: 422-9. PMID 23793263 DOI: 10.1093/bfgp/elt022  0.64
2013 Han H, Irimia M, Ross PJ, Sung HK, Alipanahi B, David L, Golipour A, Gabut M, Michael IP, Nachman EN, Wang E, Trcka D, Thompson T, O'Hanlon D, Slobodeniuc V, ... ... Moffat J, et al. MBNL proteins repress ES-cell-specific alternative splicing and reprogramming. Nature. 498: 241-5. PMID 23739326 DOI: 10.1038/nature12270  0.64
2013 Vojvodic M, Hansford LM, Morozova O, Blakely KM, Taylor P, Fathers KE, Moffat J, Marra M, Smith KM, Moran MF, Kaplan DR. A phosphoproteomics approach to identify candidate kinase inhibitor pathway targets in lymphoma-like primary cell lines. Current Drug Discovery Technologies. 10: 283-304. PMID 23701117 DOI: 10.2174/15701638113109990001  0.64
2013 Tomic J, McCaw L, Li Y, Hough MR, Ben-David Y, Moffat J, Spaner DE. Resveratrol has anti-leukemic activity associated with decreased O-GlcNAcylated proteins. Experimental Hematology. 41: 675-86. PMID 23597602 DOI: 10.1016/j.exphem.2013.04.004  0.64
2013 Findlay GM, Smith MJ, Lanner F, Hsiung MS, Gish GD, Petsalaki E, Cockburn K, Kaneko T, Huang H, Bagshaw RD, Ketela T, Tucholska M, Taylor L, Bowtell DD, Moffat J, et al. Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate. Cell. 152: 1008-20. PMID 23452850 DOI: 10.1016/j.cell.2013.01.056  0.64
2013 Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, Persaud A, Walker JR, Neculai AM, Neculai D, Vorobyov A, Garg P, Beatty L, Chan PK, Juang YC, ... ... Moffat J, et al. A strategy for modulation of enzymes in the ubiquitin system. Science (New York, N.Y.). 339: 590-5. PMID 23287719 DOI: 10.1126/science.1230161  0.64
2012 Mak AB, Nixon AM, Kittanakom S, Stewart JM, Chen GI, Curak J, Gingras AC, Mazitschek R, Neel BG, Stagljar I, Moffat J. Regulation of CD133 by HDAC6 promotes β-catenin signaling to suppress cancer cell differentiation. Cell Reports. 2: 951-63. PMID 23084749 DOI: 10.1016/j.celrep.2012.09.016  0.64
2012 Beheshti Zavareh R, Sukhai MA, Hurren R, Gronda M, Wang X, Simpson CD, Maclean N, Zih F, Ketela T, Swallow CJ, Moffat J, Rose DR, Schachter H, Schimmer AD, Dennis JW. Suppression of cancer progression by MGAT1 shRNA knockdown. Plos One. 7: e43721. PMID 22957033 DOI: 10.1371/journal.pone.0043721  0.64
2012 Tkach JM, Yimit A, Lee AY, Riffle M, Costanzo M, Jaschob D, Hendry JA, Ou J, Moffat J, Boone C, Davis TN, Nislow C, Brown GW. Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nature Cell Biology. 14: 966-76. PMID 22842922 DOI: 10.1038/ncb2549  0.64
2012 Eastwood MD, Cheung SW, Lee KY, Moffat J, Meneghini MD. Developmentally programmed nuclear destruction during yeast gametogenesis. Developmental Cell. 23: 35-44. PMID 22727375 DOI: 10.1016/j.devcel.2012.05.005  0.64
2012 Mak AB, Moffat J. A versatile lentiviral expression system to identify mammalian protein-protein interactions. Methods (San Diego, Calif.). 57: 409-16. PMID 22713554 DOI: 10.1016/j.ymeth.2012.06.005  0.64
2012 Marcotte R, Brown KR, Suarez F, Sayad A, Karamboulas K, Krzyzanowski PM, Sircoulomb F, Medrano M, Fedyshyn Y, Koh JL, van Dyk D, Fedyshyn B, Luhova M, Brito GC, Vizeacoumar FJ, ... ... Moffat J, et al. Essential gene profiles in breast, pancreatic, and ovarian cancer cells. Cancer Discovery. 2: 172-89. PMID 22585861 DOI: 10.1158/2159-8290.CD-11-0224  0.64
2012 Simpson CD, Hurren R, Kasimer D, MacLean N, Eberhard Y, Ketela T, Moffat J, Schimmer AD. A genome wide shRNA screen identifies α/β hydrolase domain containing 4 (ABHD4) as a novel regulator of anoikis resistance Apoptosis. 17: 666-678. PMID 22488300 DOI: 10.1007/s10495-012-0723-4  0.64
2012 Mak AB, Nixon AM, Moffat J. The mixed lineage leukemia (MLL) fusion-associated gene AF4 promotes CD133 transcription. Cancer Research. 72: 1929-34. PMID 22337994 DOI: 10.1158/0008-5472.CAN-11-3589  0.64
2012 Rajan S, Chu Pham Dang H, Djambazian H, Zuzan H, Fedyshyn Y, Ketela T, Moffat J, Hudson TJ, Sladek R. Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation. Physiological Genomics. 44: 183-97. PMID 22147266 DOI: 10.1152/physiolgenomics.00093.2011  0.64
2012 Koh JL, Brown KR, Sayad A, Kasimer D, Ketela T, Moffat J. COLT-Cancer: functional genetic screening resource for essential genes in human cancer cell lines. Nucleic Acids Research. 40: D957-63. PMID 22102578 DOI: 10.1093/nar/gkr959  0.64
2011 Ni Z, Olsen JB, Guo X, Zhong G, Ruan ED, Marcon E, Young P, Guo H, Li J, Moffat J, Emili A, Greenblatt JF. Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B. Transcription. 2: 237-42. PMID 22231121 DOI: 10.4161/trns.2.5.17803  0.64
2011 Skrti? M, Sriskanthadevan S, Jhas B, Gebbia M, Wang X, Wang Z, Hurren R, Jitkova Y, Gronda M, Maclean N, Lai CK, Eberhard Y, Bartoszko J, Spagnuolo P, Rutledge AC, ... ... Moffat J, et al. Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell. 20: 674-88. PMID 22094260 DOI: 10.1016/j.ccr.2011.10.015  0.64
2011 Mak AB, Blakely KM, Williams RA, Penttilä PA, Shukalyuk AI, Osman KT, Kasimer D, Ketela T, Moffat J. CD133 protein N-glycosylation processing contributes to cell surface recognition of the primitive cell marker AC133 epitope. The Journal of Biological Chemistry. 286: 41046-56. PMID 21937449 DOI: 10.1074/jbc.M111.261545  0.64
2011 Han H, Nutiu R, Moffat J, Blencowe BJ. SnapShot: High-throughput sequencing applications. Cell. 146: 1044, 1044.e1-2. PMID 21925324 DOI: 10.1016/j.cell.2011.09.002  0.64
2011 Blakely K, Ketela T, Moffat J. Pooled lentiviral shRNA screening for functional genomics in mammalian cells. Methods in Molecular Biology (Clifton, N.J.). 781: 161-82. PMID 21877282 DOI: 10.1007/978-1-61779-276-2_9  0.64
2011 Ketela T, Heisler LE, Brown KR, Ammar R, Kasimer D, Surendra A, Ericson E, Blakely K, Karamboulas D, Smith AM, Durbic T, Arnoldo A, Cheung-Ong K, Koh JL, Gopal S, ... ... Moffat J, et al. A comprehensive platform for highly multiplexed mammalian functional genetic screens. Bmc Genomics. 12: 213. PMID 21548937 DOI: 10.1186/1471-2164-12-213  0.64
2011 Eberhard Y, Gronda M, Hurren R, Datti A, MacLean N, Ketela T, Moffat J, Wrana JL, Schimmer AD. Inhibition of SREBP1 sensitizes cells to death ligands Oncotarget. 2: 186-196. PMID 21406729  0.64
2010 Chung J, Lau J, Cheng LS, Grant RI, Robinson F, Ketela T, Reis PP, Roche O, Kamel-Reid S, Moffat J, Ohh M, Perez-Ordonez B, Kaplan DR, Irwin MS. SATB2 augments ΔNp63α in head and neck squamous cell carcinoma. Embo Reports. 11: 777-83. PMID 20829881 DOI: 10.1038/embor.2010.125  0.64
2010 Smith KM, Datti A, Fujitani M, Grinshtein N, Zhang L, Morozova O, Blakely KM, Rotenberg SA, Hansford LM, Miller FD, Yeger H, Irwin MS, Moffat J, Marra MA, Baruchel S, et al. Selective targeting of neuroblastoma tumour-initiating cells by compounds identified in stem cell-based small molecule screens. Embo Molecular Medicine. 2: 371-84. PMID 20721990 DOI: 10.1002/emmm.201000093  0.64
2010 Morozova O, Vojvodic M, Grinshtein N, Hansford LM, Blakely KM, Maslova A, Hirst M, Cezard T, Morin RD, Moore R, Smith KM, Miller F, Taylor P, Thiessen N, Varhol R, ... ... Moffat J, et al. System-level analysis of neuroblastoma tumor-initiating cells implicates AURKB as a novel drug target for neuroblastoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 4572-82. PMID 20651058 DOI: 10.1158/1078-0432.CCR-10-0627  0.64
2010 Mak AB, Ni Z, Hewel JA, Chen GI, Zhong G, Karamboulas K, Blakely K, Smiley S, Marcon E, Roudeva D, Li J, Olsen JB, Wan C, Punna T, Isserlin R, ... ... Moffat J, et al. A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency. Molecular & Cellular Proteomics : McP. 9: 811-23. PMID 20305087 DOI: 10.1074/mcp.M000002-MCP201  0.64
2010 Xu GW, Ali M, Wood TE, Wong D, Maclean N, Wang X, Gronda M, Skrtic M, Li X, Hurren R, Mao X, Venkatesan M, Beheshti Zavareh R, Ketela T, Reed JC, ... ... Moffat J, et al. The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma. Blood. 115: 2251-9. PMID 20075161 DOI: 10.1182/blood-2009-07-231191  0.64
2010 Wood TE, Dalili S, Simpson CD, Sukhai MA, Hurren R, Anyiwe K, Mao X, Suarez Saiz F, Gronda M, Eberhard Y, MacLean N, Ketela T, Reed JC, Moffat J, Minden MD, et al. Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Molecular Cancer Therapeutics. 9: 246-56. PMID 20053768 DOI: 10.1158/1535-7163.MCT-09-0495  0.64
2009 Huang D, Kaluarachchi S, van Dyk D, Friesen H, Sopko R, Ye W, Bastajian N, Moffat J, Sassi H, Costanzo M, Andrews BJ. Dual regulation by pairs of cyclin-dependent protein kinases and histone deacetylases controls G1 transcription in budding yeast. Plos Biology. 7: e1000188. PMID 19823668 DOI: 10.1371/journal.pbio.1000188  0.64
2009 Jones TR, Carpenter AE, Lamprecht MR, Moffat J, Silver SJ, Grenier JK, Castoreno AB, Eggert US, Root DE, Golland P, Sabatini DM. Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning. Proceedings of the National Academy of Sciences of the United States of America. 106: 1826-31. PMID 19188593 DOI: 10.1073/pnas.0808843106  0.64
2007 Moffat J, Reiling JH, Sabatini DM. Off-target effects associated with long dsRNAs in Drosophila RNAi screens. Trends in Pharmacological Sciences. 28: 149-51. PMID 17350110 DOI: 10.1016/j.tips.2007.02.009  0.64
2006 Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Developmental Cell. 11: 859-71. PMID 17141160 DOI: 10.1016/j.devcel.2006.10.007  0.64
2006 Carpenter AE, Jones TR, Lamprecht MR, Clarke C, Kang IH, Friman O, Guertin DA, Chang JH, Lindquist RA, Moffat J, Golland P, Sabatini DM. CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biology. 7: R100. PMID 17076895 DOI: 10.1186/gb-2006-7-10-r100  0.64
2006 Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N, et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell. 124: 1283-98. PMID 16564017 DOI: 10.1016/j.cell.2006.01.040  0.64
2006 Moffat J, Sabatini DM. Building mammalian signalling pathways with RNAi screens Nature Reviews Molecular Cell Biology. 7: 177-187. PMID 16496020 DOI: 10.1038/nrm1860  0.64
2004 Mnaimneh S, Davierwala AP, Haynes J, Moffat J, Peng WT, Zhang W, Yang X, Pootoolal J, Chua G, Lopez A, Trochesset M, Morse D, Krogan NJ, Hiley SL, Li Z, et al. Exploration of essential gene functions via titratable promoter alleles. Cell. 118: 31-44. PMID 15242642 DOI: 10.1016/j.cell.2004.06.013  0.64
2004 Moffat J, Andrews B. Late-G1 cyclin-CDK activity is essential for control of cell morphogenesis in budding yeast. Nature Cell Biology. 6: 59-66. PMID 14688790 DOI: 10.1038/ncb1078  0.96
2003 Willis KA, Barbara KE, Menon BB, Moffat J, Andrews B, Santangelo GM. The global transcriptional activator of Saccharomyces cerevisiae, Gcr1p, mediates the response to glucose by stimulating protein synthesis and CLN-dependent cell cycle progression. Genetics. 165: 1017-29. PMID 14668361  0.64
2003 Moffat J, Andrews B. Ac'septin' a signal: kinase regulation by septins. Developmental Cell. 5: 528-30. PMID 14536051  0.96
2002 Huang D, Moffat J, Andrews B. Dissection of a complex phenotype by functional genomics reveals roles for the yeast cyclin-dependent protein kinase Pho85 in stress adaptation and cell integrity. Molecular and Cellular Biology. 22: 5076-88. PMID 12077337  0.96
2001 McBride HJ, Sil A, Measday V, Yu Y, Moffat J, Maxon ME, Herskowitz I, Andrews B, Stillman DJ. The protein kinase Pho85 is required for asymmetric accumulation of the Ash1 protein in Saccharomyces cerevisiae. Molecular Microbiology. 42: 345-53. PMID 11703659 DOI: 10.1046/j.1365-2958.2001.02601.x  0.64
2001 Baetz K, Moffat J, Haynes J, Chang M, Andrews B. Transcriptional coregulation by the cell integrity mitogen-activated protein kinase Slt2 and the cell cycle regulator Swi4. Molecular and Cellular Biology. 21: 6515-28. PMID 11533240 DOI: 10.1128/MCB.21.19.6515-6528.2001  0.64
2000 Moffat J, Huang D, Andrews B. Functions of Pho85 cyclin-dependent kinases in budding yeast. Progress in Cell Cycle Research. 4: 97-106. PMID 10740818  0.96
2000 Measday V, McBride H, Moffat J, Stillman D, Andrews B. Interactions between Pho85 cyclin-dependent kinase complexes and the Swi5 transcription factor in budding yeast. Molecular Microbiology. 35: 825-34. PMID 10692159 DOI: 10.1046/j.1365-2958.2000.01754.x  0.64
1999 Huang D, Patrick G, Moffat J, Tsai LH, Andrews B. Mammalian Cdk5 is a functional homologue of the budding yeast Pho85 cyclin-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 96: 14445-50. PMID 10588725 DOI: 10.1073/pnas.96.25.14445  0.64
1998 Huang D, Moffat J, Wilson WA, Moore L, Cheng C, Roach PJ, Andrews B. Cyclin partners determine Pho85 protein kinase substrate specificity in vitro and in vivo: control of glycogen biosynthesis by Pcl8 and Pcl10. Molecular and Cellular Biology. 18: 3289-99. PMID 9584169  0.96
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