Michael A. Costanzo, Ph.D. - Publications

Affiliations: 
2003 University of Toronto, Toronto, ON, Canada 
Area:
Molecular Biology, Cell Biology

98 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Garadi Suresh H, Bonneil E, Albert B, Dominique C, Costanzo M, Pons C, Masinas MPD, Shuteriqi E, Shore D, Henras AK, Thibault P, Boone C, Andrews BJ. K29-linked free polyubiquitin chains affect ribosome biogenesis and direct ribosomal proteins to the intranuclear quality control compartment. Molecular Cell. PMID 38870935 DOI: 10.1016/j.molcel.2024.05.018  0.505
2024 Lin K, Chang YC, Billmann M, Ward HN, Le K, Hassan AZ, Bhojoo U, Chan K, Costanzo M, Moffat J, Boone C, Bielinsky AK, Myers CL. A scalable platform for efficient CRISPR-Cas9 chemical-genetic screens of DNA damage-inducing compounds. Scientific Reports. 14: 2508. PMID 38291084 DOI: 10.1038/s41598-024-51735-y  0.532
2023 Varland S, Silva RD, Kjosås I, Faustino A, Bogaert A, Billmann M, Boukhatmi H, Kellen B, Costanzo M, Drazic A, Osberg C, Chan K, Zhang X, Tong AHY, Andreazza S, et al. N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity. Nature Communications. 14: 6774. PMID 37891180 DOI: 10.1038/s41467-023-42342-y  0.658
2023 Suresh HG, Bonneil E, Albert B, Dominique C, Costanzo M, Pons C, David Masinas MP, Shuteriqi E, Shore D, Henras AK, Thibault P, Boone C, Andrews BJ. K29-linked unanchored polyubiquitin chains disrupt ribosome biogenesis and direct ribosomal proteins to the Intranuclear Quality control compartment (INQ). Biorxiv : the Preprint Server For Biology. PMID 37205480 DOI: 10.1101/2023.05.03.539259  0.505
2023 Billmann M, Ward HN, Aregger M, Costanzo M, Andrews BJ, Boone C, Moffat J, Myers CL. Reproducibility metrics for context-specific CRISPR screens. Cell Systems. 14: 418-422.e2. PMID 37201508 DOI: 10.1016/j.cels.2023.04.003  0.652
2022 Conti MM, Ghizzoni JM, Gil-Bona A, Wang W, Costanzo M, Li R, Flynn MJ, Zhu LJ, Myers CL, Boone C, Andrews BJ, Benanti JA. Repression of essential cell cycle genes increases cellular fitness. Plos Genetics. 18: e1010349. PMID 36037231 DOI: 10.1371/journal.pgen.1010349  0.614
2021 Rahman M, Billmann M, Costanzo M, Aregger M, Tong AHY, Chan K, Ward HN, Brown KR, Andrews BJ, Boone C, Moffat J, Myers CL. A method for benchmarking genetic screens reveals a predominant mitochondrial bias. Molecular Systems Biology. 17: e10013. PMID 34018332 DOI: 10.15252/msb.202010013  0.688
2021 Kong KE, Fischer B, Meurer M, Kats I, Li Z, Rühle F, Barry JD, Kirrmaier D, Chevyreva V, San Luis BJ, Costanzo M, Huber W, Andrews BJ, Boone C, Knop M, et al. Timer-based proteomic profiling of the ubiquitin-proteasome system reveals a substrate receptor of the GID ubiquitin ligase. Molecular Cell. PMID 33974913 DOI: 10.1016/j.molcel.2021.04.018  0.504
2021 Costanzo M, Hou J, Messier V, Nelson J, Rahman M, VanderSluis B, Wang W, Pons C, Ross C, Ušaj M, San Luis BJ, Shuteriqi E, Koch EN, Aloy P, Myers CL, et al. Environmental robustness of the global yeast genetic interaction network. Science (New York, N.Y.). 372. PMID 33958448 DOI: 10.1126/science.abf8424  0.657
2021 Kuzmin E, Rahman M, VanderSluis B, Costanzo M, Myers CL, Andrews BJ, Boone C. τ-SGA: synthetic genetic array analysis for systematically screening and quantifying trigenic interactions in yeast. Nature Protocols. PMID 33462440 DOI: 10.1038/s41596-020-00456-3  0.593
2020 Aregger M, Lawson KA, Billmann M, Costanzo M, Tong AHY, Chan K, Rahman M, Brown KR, Ross C, Usaj M, Nedyalkova L, Sizova O, Habsid A, Pawling J, Lin ZY, et al. Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism. Nature Metabolism. 2: 499-513. PMID 32694731 DOI: 10.1038/s42255-020-0211-z  0.676
2020 Kuzmin E, VanderSluis B, Nguyen Ba AN, Wang W, Koch EN, Usaj M, Khmelinskii A, Usaj MM, van Leeuwen J, Kraus O, Tresenrider A, Pryszlak M, Hu MC, Varriano B, Costanzo M, et al. Exploring whole-genome duplicate gene retention with complex genetic interaction analysis. Science (New York, N.Y.). 368. PMID 32586993 DOI: 10.1126/Science.Aaz5667  0.661
2020 Eisenstatt JR, Boeckmann L, Au WC, Garcia V, Bursch L, Ocampo J, Costanzo M, Weinreich M, Sclafani RA, Baryshnikova A, Myers CL, Boone C, Clark DJ, Baker R, Basrai MA. Dbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in . G3 (Bethesda, Md.). PMID 32295767 DOI: 10.1534/G3.120.401131  0.381
2020 Au WC, Zhang T, Mishra PK, Eisenstatt JR, Walker RL, Ocampo J, Dawson A, Warren J, Costanzo M, Baryshnikova A, Flick K, Clark DJ, Meltzer PS, Baker RE, Myers C, et al. Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast. Plos Genetics. 16: e1008597. PMID 32032354 DOI: 10.1371/Journal.Pgen.1008597  0.418
2019 Fang G, Wang W, Paunic V, Heydari H, Costanzo M, Liu X, Liu X, VanderSluis B, Oately B, Steinbach M, Van Ness B, Schadt EE, Pankratz ND, Boone C, Kumar V, et al. Discovering genetic interactions bridging pathways in genome-wide association studies. Nature Communications. 10: 4274. PMID 31537791 DOI: 10.1038/S41467-019-12131-7  0.507
2019 Corcoles-Saez I, Ferat JL, Costanzo M, Boone CM, Cha RS. Functional link between mitochondria and Rnr3, the minor catalytic subunit of yeast ribonucleotide reductase. Microbial Cell (Graz, Austria). 6: 286-294. PMID 31172013 DOI: 10.15698/Mic2019.06.680  0.334
2019 Costanzo M, Kuzmin E, van Leeuwen J, Mair B, Moffat J, Boone C, Andrews B. Global Genetic Networks and the Genotype-to-Phenotype Relationship. Cell. 177: 85-100. PMID 30901552 DOI: 10.1016/J.Cell.2019.01.033  0.751
2019 Pascoe N, Seetharaman A, Teyra J, Manczyk N, Satori MA, Tjandra D, Makhnevych T, Schwerdtfeger C, Brasher BB, Moffat J, Costanzo M, Boone C, Sicheri F, Sidhu S. Yeast Two-Hybrid Analysis for Ubiquitin-Variant Inhibitors of Human Deubiquitinases. Journal of Molecular Biology. PMID 30763569 DOI: 10.1016/J.Jmb.2019.02.007  0.594
2018 Simpkins SW, Nelson J, Deshpande R, Li SC, Piotrowski JS, Wilson EH, Gebre AA, Safizadeh H, Okamoto R, Yoshimura M, Costanzo M, Yashiroda Y, Ohya Y, Osada H, Yoshida M, et al. Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions. Plos Computational Biology. 14: e1006532. PMID 30376562 DOI: 10.1371/Journal.Pcbi.1006532  0.495
2018 Corcoles-Saez I, Dong K, Johnson AL, Waskiewicz E, Costanzo M, Boone C, Cha RS. Essential Function of Mec1, the Budding Yeast ATM/ATR Checkpoint-Response Kinase, in Protein Homeostasis. Developmental Cell. 46: 495-503.e2. PMID 30130531 DOI: 10.1016/J.Devcel.2018.07.011  0.411
2018 VanderSluis B, Costanzo M, Billmann M, Ward HN, Myers CL, Andrews BJ, Boone C. Integrating genetic and protein-protein interaction networks maps a functional wiring diagram of a cell. Current Opinion in Microbiology. 45: 170-179. PMID 30059827 DOI: 10.1016/J.Mib.2018.06.004  0.677
2018 Ciftci-Yilmaz S, Au WC, Mishra PK, Eisenstatt JR, Chang J, Dawson AR, Zhu I, Rahman M, Bilke S, Costanzo M, Baryshnikova A, Myers CL, Meltzer PS, Landsman D, Baker RE, et al. A Genome-Wide Screen Reveals a Role for the HIR Histone Chaperone Complex in Preventing Mislocalization of Budding Yeast CENP-A. Genetics. PMID 30012561 DOI: 10.1534/Genetics.118.301305  0.435
2018 Sing TL, Hung MP, Ohnuki S, Suzuki G, San Luis BJ, McClain M, Unruh JR, Yu Z, Ou J, Marshall-Sheppard J, Huh WK, Costanzo M, Boone C, Ohya Y, Jaspersen SL, et al. The budding yeast RSC complex maintains ploidy by promoting spindle pole body insertion. The Journal of Cell Biology. PMID 29875260 DOI: 10.1083/Jcb.201709009  0.352
2018 Mount HO, Revie NM, Todd RT, Anstett K, Collins C, Costanzo M, Boone C, Robbins N, Selmecki A, Cowen LE. Global analysis of genetic circuitry and adaptive mechanisms enabling resistance to the azole antifungal drugs. Plos Genetics. 14: e1007319. PMID 29702647 DOI: 10.1371/Journal.Pgen.1007319  0.387
2018 Kuzmin E, VanderSluis B, Wang W, Tan G, Deshpande R, Chen Y, Usaj M, Balint A, Mattiazzi Usaj M, van Leeuwen J, Koch EN, Pons C, Dagilis AJ, Pryszlak M, Wang JZY, ... ... Costanzo M, et al. Systematic analysis of complex genetic interactions. Science (New York, N.Y.). 360. PMID 29674565 DOI: 10.1126/Science.Aao1729  0.82
2017 Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilson E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, ... ... Costanzo M, et al. Errata: Functional annotation of chemical libraries across diverse biological processes. Nature Chemical Biology. 13: 1286. PMID 29161247 DOI: 10.1038/nchembio1217-1286a  0.476
2017 Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilson E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, ... ... Costanzo M, et al. Errata: Functional annotation of chemical libraries across diverse biological processes. Nature Chemical Biology. 13: 1286. PMID 29161244 DOI: 10.1038/nchembio1217-1286b  0.476
2017 Wang W, Xu ZZ, Costanzo M, Boone C, Lange CA, Myers CL. Pathway-based discovery of genetic interactions in breast cancer. Plos Genetics. 13: e1006973. PMID 28957314 DOI: 10.1371/Journal.Pgen.1006973  0.424
2017 Rizzolo K, Huen J, Kumar A, Phanse S, Vlasblom J, Kakihara Y, Zeineddine HA, Minic Z, Snider J, Wang W, Pons C, Seraphim TV, Boczek EE, Alberti S, Costanzo M, et al. Features of the Chaperone Cellular Network Revealed through Systematic Interaction Mapping. Cell Reports. 20: 2735-2748. PMID 28903051 DOI: 10.1016/J.Celrep.2017.08.074  0.471
2017 Piotrowski JS, Li SC, Deshpande R, Simpkins SW, Nelson J, Yashiroda Y, Barber JM, Safizadeh H, Wilson E, Okada H, Gebre AA, Kubo K, Torres NP, LeBlanc MA, Andrusiak K, ... ... Costanzo M, et al. Functional annotation of chemical libraries across diverse biological processes. Nature Chemical Biology. PMID 28759014 DOI: 10.1038/Nchembio.2436  0.627
2017 Yang F, Sun S, Tan G, Costanzo M, Hill DE, Vidal M, Andrews BJ, Boone C, Roth FP. Identifying pathogenicity of human variants via paralog-based yeast complementation. Plos Genetics. 13: e1006779. PMID 28542158 DOI: 10.1371/Journal.Pgen.1006779  0.611
2017 Usaj M, Tan Y, Wang W, VanderSluis B, Zou A, Myers CL, Costanzo M, Andrews B, Boone C. TheCellMap.org: A Web-Accessible Database for Visualizing and Mining the Global Yeast Genetic Interaction Network. G3 (Bethesda, Md.). PMID 28325812 DOI: 10.1534/G3.117.040220  0.648
2017 Khurana V, Peng J, Chung CY, Auluck PK, Fanning S, Tardiff DF, Bartels T, Koeva M, Eichhorn SW, Benyamini H, Lou Y, Nutter-Upham A, Baru V, Freyzon Y, Tuncbag N, ... Costanzo M, et al. Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways. Cell Systems. PMID 28131822 DOI: 10.1016/J.Cels.2016.12.011  0.429
2016 Shyian M, Mattarocci S, Albert B, Hafner L, Lezaja A, Costanzo M, Boone C, Shore D. Budding Yeast Rif1 Controls Genome Integrity by Inhibiting rDNA Replication. Plos Genetics. 12: e1006414. PMID 27820830 DOI: 10.1371/Journal.Pgen.1006414  0.382
2016 van Leeuwen J, Pons C, Mellor JC, Yamaguchi TN, Friesen H, Koschwanez J, Ušaj MM, Pechlaner M, Takar M, Ušaj M, VanderSluis B, Andrusiak K, Bansal P, Baryshnikova A, Boone CE, ... ... Costanzo M, et al. Exploring genetic suppression interactions on a global scale. Science (New York, N.Y.). 354. PMID 27811238 DOI: 10.1126/Science.Aag0839  0.671
2016 Costanzo M, VanderSluis B, Koch EN, Baryshnikova A, Pons C, Tan G, Wang W, Usaj M, Hanchard J, Lee SD, Pelechano V, Styles EB, Billmann M, van Leeuwen J, van Dyk N, et al. A global genetic interaction network maps a wiring diagram of cellular function. Science (New York, N.Y.). 353. PMID 27708008 DOI: 10.1126/Science.Aaf1420  0.828
2016 Styles EB, Founk KJ, Zamparo LA, Sing TL, Altintas D, Ribeyre C, Ribaud V, Rougemont J, Mayhew D, Costanzo M, Usaj M, Verster AJ, Koch EN, Novarina D, Graf M, et al. Exploring Quantitative Yeast Phenomics with Single-Cell Analysis of DNA Damage Foci. Cell Systems. PMID 27617677 DOI: 10.1016/J.Cels.2016.08.008  0.604
2016 Kuzmin E, Costanzo M, Andrews B, Boone C. Synthetic Genetic Arrays: Automation of Yeast Genetics. Cold Spring Harbor Protocols. 2016: pdb.top086652. PMID 27037078 DOI: 10.1101/Pdb.Top086652  0.711
2016 Kuzmin E, Costanzo M, Andrews B, Boone C. Synthetic Genetic Array Analysis. Cold Spring Harbor Protocols. 2016: pdb.prot088807. PMID 27037072 DOI: 10.1101/Pdb.Prot088807  0.685
2016 Sun S, Yang F, Tan G, Costanzo M, Oughtred R, Hirschman J, Theesfeld C, Bansal P, Sahni N, Yi S, Yu A, Tyagi T, Tie C, Hill DE, Vidal M, et al. An extended set of yeast-based functional assays accurately identifies human disease mutations. Genome Research. PMID 26975778 DOI: 10.1101/Gr.192526.115  0.593
2016 Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, ... ... Costanzo M, et al. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell. 164: 805-817. PMID 26871637 DOI: 10.1016/J.Cell.2016.01.029  0.634
2016 Dodgson SE, Kim S, Costanzo M, Baryshnikova A, Morse DL, Kaiser CA, Boone C, Amon A. Chromosome-Specific and Global Effects of Aneuploidy in Saccharomyces cerevisiae. Genetics. PMID 26837754 DOI: 10.1534/Genetics.115.185660  0.378
2016 Yerlikaya S, Meusburger M, Kumari R, Huber A, Anrather D, Costanzo M, Boone C, Ammerer G, Baranov PV, Loewith R. TORC1 and TORC2 work together to regulate ribosomal protein S6 phosphorylation in Saccharomyces cerevisiae. Molecular Biology of the Cell. 27: 397-409. PMID 26582391 DOI: 10.1091/Mbc.E15-08-0594  0.368
2015 Becker JR, Pons C, Nguyen HD, Costanzo M, Boone C, Myers CL, Bielinsky AK. Genetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing. Plos Genetics. 11: e1005659. PMID 26545110 DOI: 10.1371/Journal.Pgen.1005659  0.356
2014 Kuzmin E, Sharifpoor S, Baryshnikova A, Costanzo M, Myers CL, Andrews BJ, Boone C. Synthetic genetic array analysis for global mapping of genetic networks in yeast. Methods in Molecular Biology (Clifton, N.J.). 1205: 143-68. PMID 25213244 DOI: 10.1007/978-1-4939-1363-3_10  0.83
2014 Aiken J, Sept D, Costanzo M, Boone C, Cooper JA, Moore JK. Genome-wide analysis reveals novel and discrete functions for tubulin carboxy-terminal tails. Current Biology : Cb. 24: 1295-303. PMID 24835459 DOI: 10.1016/J.Cub.2014.03.078  0.342
2013 Deshpande R, Asiedu MK, Klebig M, Sutor S, Kuzmin E, Nelson J, Piotrowski J, Shin SH, Yoshida M, Costanzo M, Boone C, Wigle DA, Myers CL. A comparative genomic approach for identifying synthetic lethal interactions in human cancer. Cancer Research. 73: 6128-36. PMID 23980094 DOI: 10.1158/0008-5472.Can-12-3956  0.411
2013 Baryshnikova A, VanderSluis B, Costanzo M, Myers CL, Cha RS, Andrews B, Boone C. Global linkage map connects meiotic centromere function to chromosome size in budding yeast. G3 (Bethesda, Md.). 3: 1741-51. PMID 23979930 DOI: 10.1534/G3.113.007377  0.575
2013 Nguyen HD, Becker J, Thu YM, Costanzo M, Koch EN, Smith S, Myung K, Myers CL, Boone C, Bielinsky AK. Unligated Okazaki Fragments Induce PCNA Ubiquitination and a Requirement for Rad59-Dependent Replication Fork Progression. Plos One. 8: e66379. PMID 23824283 DOI: 10.1371/Journal.Pone.0066379  0.376
2013 Baryshnikova A, Costanzo M, Myers CL, Andrews B, Boone C. Genetic interaction networks: toward an understanding of heritability. Annual Review of Genomics and Human Genetics. 14: 111-33. PMID 23808365 DOI: 10.1146/Annurev-Genom-082509-141730  0.683
2013 Wagih O, Usaj M, Baryshnikova A, VanderSluis B, Kuzmin E, Costanzo M, Myers CL, Andrews BJ, Boone CM, Parts L. SGAtools: one-stop analysis and visualization of array-based genetic interaction screens. Nucleic Acids Research. 41: W591-6. PMID 23677617 DOI: 10.1093/nar/gkt400  0.632
2013 Srikumar T, Lewicki MC, Costanzo M, Tkach JM, van Bakel H, Tsui K, Johnson ES, Brown GW, Andrews BJ, Boone C, Giaever G, Nislow C, Raught B. Global analysis of SUMO chain function reveals multiple roles in chromatin regulation. The Journal of Cell Biology. 201: 145-63. PMID 23547032 DOI: 10.1083/Jcb.201210019  0.593
2013 Michelot A, Grassart A, Okreglak V, Costanzo M, Boone C, Drubin DG. Actin filament elongation in Arp2/3-derived networks is controlled by three distinct mechanisms. Developmental Cell. 24: 182-95. PMID 23333351 DOI: 10.1016/J.Devcel.2012.12.008  0.316
2013 Asiedu MK, Deshpande R, Klebig M, Sutor S, Kuzmin E, Piotrowski J, Shin SH, Costanzo M, Boone C, Wigle DA, Myers CL. Abstract LB-234: A comparative genomic approach for identifying synthetic lethal interactions in human cancer. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-234  0.408
2012 Ryan O, Shapiro RS, Kurat CF, Mayhew D, Baryshnikova A, Chin B, Lin ZY, Cox MJ, Vizeacoumar F, Cheung D, Bahr S, Tsui K, Tebbji F, Sellam A, Istel F, ... ... Costanzo M, et al. Global gene deletion analysis exploring yeast filamentous growth. Science (New York, N.Y.). 337: 1353-6. PMID 22984072 DOI: 10.1126/Science.1224339  0.593
2012 Tkach JM, Yimit A, Lee AY, Riffle M, Costanzo M, Jaschob D, Hendry JA, Ou J, Moffat J, Boone C, Davis TN, Nislow C, Brown GW. Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nature Cell Biology. 14: 966-76. PMID 22842922 DOI: 10.1038/Ncb2549  0.597
2012 Koch EN, Costanzo M, Bellay J, Deshpande R, Chatfield-Reed K, Chua G, D'Urso G, Andrews BJ, Boone C, Myers CL. Conserved rules govern genetic interaction degree across species. Genome Biology. 13: R57. PMID 22747640 DOI: 10.1186/Gb-2012-13-7-R57  0.674
2012 Sun MG, Sikora M, Costanzo M, Boone C, Kim PM. Network evolution: rewiring and signatures of conservation in signaling. Plos Computational Biology. 8: e1002411. PMID 22438796 DOI: 10.1371/Journal.Pcbi.1002411  0.395
2012 Sharifpoor S, van Dyk D, Costanzo M, Baryshnikova A, Friesen H, Douglas AC, Youn JY, VanderSluis B, Myers CL, Papp B, Boone C, Andrews BJ. Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs. Genome Research. 22: 791-801. PMID 22282571 DOI: 10.1101/Gr.129213.111  0.826
2011 Hoon S, Gebbia M, Costanzo M, Davis RW, Giaever G, Nislow C. A global perspective of the genetic basis for carbonyl stress resistance. G3 (Bethesda, Md.). 1: 219-31. PMID 22384333 DOI: 10.1534/G3.111.000505  0.439
2011 Cokol M, Chua HN, Tasan M, Mutlu B, Weinstein ZB, Suzuki Y, Nergiz ME, Costanzo M, Baryshnikova A, Giaever G, Nislow C, Myers CL, Andrews BJ, Boone C, Roth FP. Systematic exploration of synergistic drug pairs. Molecular Systems Biology. 7: 544. PMID 22068327 DOI: 10.1038/Msb.2011.71  0.532
2011 Liu C, van Dyk D, Choe V, Yan J, Majumder S, Costanzo M, Bao X, Boone C, Huo K, Winey M, Fisk H, Andrews B, Rao H. Ubiquitin ligase Ufd2 is required for efficient degradation of Mps1 kinase. The Journal of Biological Chemistry. 286: 43660-7. PMID 22045814 DOI: 10.1074/Jbc.M111.286229  0.578
2011 Zhu X, Zhang Y, Bjornsdottir G, Liu Z, Quan A, Costanzo M, Dávila López M, Westholm JO, Ronne H, Boone C, Gustafsson CM, Myers LC. Histone modifications influence mediator interactions with chromatin. Nucleic Acids Research. 39: 8342-54. PMID 21742760 DOI: 10.1093/Nar/Gkr551  0.347
2011 Bellay J, Atluri G, Sing TL, Toufighi K, Costanzo M, Ribeiro PS, Pandey G, Baller J, VanderSluis B, Michaut M, Han S, Kim P, Brown GW, Andrews BJ, Boone C, et al. Putting genetic interactions in context through a global modular decomposition. Genome Research. 21: 1375-87. PMID 21715556 DOI: 10.1101/Gr.117176.110  0.693
2011 Szappanos B, Kovács K, Szamecz B, Honti F, Costanzo M, Baryshnikova A, Gelius-Dietrich G, Lercher MJ, Jelasity M, Myers CL, Andrews BJ, Boone C, Oliver SG, Pál C, Papp B. An integrated approach to characterize genetic interaction networks in yeast metabolism. Nature Genetics. 43: 656-62. PMID 21623372 DOI: 10.1038/Ng.846  0.625
2011 Magtanong L, Ho CH, Barker SL, Jiao W, Baryshnikova A, Bahr S, Smith AM, Heisler LE, Choy JS, Kuzmin E, Andrusiak K, Kobylianski A, Li Z, Costanzo M, Basrai MA, et al. Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell. Nature Biotechnology. 29: 505-11. PMID 21572441 DOI: 10.1038/Nbt.1855  0.692
2011 Li Z, Vizeacoumar FJ, Bahr S, Li J, Warringer J, Vizeacoumar FS, Min R, Vandersluis B, Bellay J, Devit M, Fleming JA, Stephens A, Haase J, Lin ZY, Baryshnikova A, ... ... Costanzo M, et al. Systematic exploration of essential yeast gene function with temperature-sensitive mutants. Nature Biotechnology. 29: 361-7. PMID 21441928 DOI: 10.1038/Nbt.1832  0.657
2011 Michaut M, Baryshnikova A, Costanzo M, Myers CL, Andrews BJ, Boone C, Bader GD. Protein complexes are central in the yeast genetic landscape. Plos Computational Biology. 7: e1001092. PMID 21390331 DOI: 10.1371/Journal.Pcbi.1001092  0.65
2011 Bellay J, Han S, Michaut M, Kim T, Costanzo M, Andrews BJ, Boone C, Bader GD, Myers CL, Kim PM. Bringing order to protein disorder through comparative genomics and genetic interactions. Genome Biology. 12: R14. PMID 21324131 DOI: 10.1186/Gb-2011-12-2-R14  0.534
2011 Luo G, Costanzo M, Boone C, Dickson RC. Nutrients and the Pkh1/2 and Pkc1 protein kinases control mRNA decay and P-body assembly in yeast Journal of Biological Chemistry. 286: 8759-8770. PMID 21163942 DOI: 10.1074/Jbc.M110.196030  0.304
2011 Costanzo M, Baryshnikova A, Myers CL, Andrews B, Boone C. Charting the genetic interaction map of a cell. Current Opinion in Biotechnology. 22: 66-74. PMID 21111604 DOI: 10.1016/J.Copbio.2010.11.001  0.695
2011 Ho CH, Piotrowski J, Dixon SJ, Baryshnikova A, Costanzo M, Boone C. Combining functional genomics and chemical biology to identify targets of bioactive compounds. Current Opinion in Chemical Biology. 15: 66-78. PMID 21093351 DOI: 10.1016/J.Cbpa.2010.10.023  0.428
2010 Greenland KB, Ding H, Costanzo M, Boone C, Davis TN. Identification of Saccharomyces cerevisiae spindle pole body remodeling factors Plos One. 5. PMID 21103054 DOI: 10.1371/Journal.Pone.0015426  0.449
2010 VanderSluis B, Bellay J, Musso G, Costanzo M, Papp B, Vizeacoumar FJ, Baryshnikova A, Andrews B, Boone C, Myers CL. Genetic interactions reveal the evolutionary trajectories of duplicate genes. Molecular Systems Biology. 6: 429. PMID 21081923 DOI: 10.1038/Msb.2010.82  0.691
2010 Baryshnikova A, Costanzo M, Kim Y, Ding H, Koh J, Toufighi K, Youn JY, Ou J, San Luis BJ, Bandyopadhyay S, Hibbs M, Hess D, Gingras AC, Bader GD, Troyanskaya OG, et al. Quantitative analysis of fitness and genetic interactions in yeast on a genome scale. Nature Methods. 7: 1017-24. PMID 21076421 DOI: 10.1038/Nmeth.1534  0.697
2010 Michelot A, Costanzo M, Sarkeshik A, Boone C, Yates JR, Drubin DG. Reconstitution and protein composition analysis of endocytic actin patches. Current Biology : Cb. 20: 1890-9. PMID 21035341 DOI: 10.1016/J.Cub.2010.10.016  0.359
2010 Baryshnikova A, Costanzo M, Dixon S, Vizeacoumar FJ, Myers CL, Andrews B, Boone C. Synthetic genetic array (SGA) analysis in Saccharomyces cerevisiae and Schizosaccharomyces pombe. Methods in Enzymology. 470: 145-79. PMID 20946810 DOI: 10.1016/S0076-6879(10)70007-0  0.709
2010 Costanzo M, Baryshnikova A, Bellay J, Kim Y, Spear ED, Sevier CS, Ding H, Koh JL, Toufighi K, Mostafavi S, Prinz J, St Onge RP, VanderSluis B, Makhnevych T, Vizeacoumar FJ, et al. The genetic landscape of a cell. Science (New York, N.Y.). 327: 425-31. PMID 20093466 DOI: 10.1126/Science.1180823  0.703
2010 Koh JL, Ding H, Costanzo M, Baryshnikova A, Toufighi K, Bader GD, Myers CL, Andrews BJ, Boone C. DRYGIN: a database of quantitative genetic interaction networks in yeast. Nucleic Acids Research. 38: D502-7. PMID 19880385 DOI: 10.1093/Nar/Gkp820  0.664
2010 Michaut M, Baryshnikova A, Costanzo M, Myers CL, Andrews B, Boone C, Bader GD. Exploring the Monochromatic Landscape in Yeast using Genetic Interactions and Known Processes Reveals the Importance of Protein Complexes F1000research. 1. DOI: 10.7490/F1000Research.266.1  0.668
2009 Costanzo M, Baryshnikova A, Nislow C, Andrews B, Boone C. You too can play with an edge. Nature Methods. 6: 797-8. PMID 19876015 DOI: 10.1038/Nmeth1109-797  0.61
2009 Huang D, Kaluarachchi S, van Dyk D, Friesen H, Sopko R, Ye W, Bastajian N, Moffat J, Sassi H, Costanzo M, Andrews BJ. Dual regulation by pairs of cyclin-dependent protein kinases and histone deacetylases controls G1 transcription in budding yeast. Plos Biology. 7: e1000188. PMID 19823668 DOI: 10.1371/Journal.Pbio.1000188  0.696
2009 Dixon SJ, Costanzo M, Baryshnikova A, Andrews B, Boone C. Systematic mapping of genetic interaction networks. Annual Review of Genetics. 43: 601-25. PMID 19712041 DOI: 10.1146/Annurev.Genet.39.073003.114751  0.689
2009 Costanzo M, Boone C. SGAM: An array-based approach for high-resolution genetic mapping in saccharomyces cerevisiae Methods in Molecular Biology. 548: 37-53. PMID 19521818 DOI: 10.1007/978-1-59745-540-4_3  0.529
2009 Hess DC, Myers CL, Huttenhower C, Hibbs MA, Hayes AP, Paw J, Clore JJ, Mendoza RM, Luis BS, Nislow C, Giaever G, Costanzo M, Troyanskaya OG, Caudy AA. Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. Plos Genetics. 5: e1000407. PMID 19300474 DOI: 10.1371/Journal.Pgen.1000407  0.374
2009 Leidel S, Pedrioli PG, Bucher T, Brost R, Costanzo M, Schmidt A, Aebersold R, Boone C, Hofmann K, Peter M. Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA. Nature. 458: 228-32. PMID 19145231 DOI: 10.1038/Nature07643  0.336
2009 Ozanick SG, Wang X, Costanzo M, Brost RL, Boone C, Anderson JT. Rex1p deficiency leads to accumulation of precursor initiator tRNAMet and polyadenylation of substrate RNAs in Saccharomyces cerevisiae. Nucleic Acids Research. 37: 298-308. PMID 19042972 DOI: 10.1093/Nar/Gkn925  0.393
2008 Hausmann S, Zheng S, Costanzo M, Brost RL, Garcin D, Boone C, Shuman S, Schwer B. Genetic and biochemical analysis of yeast and human cap trimethylguanosine synthase: functional overlap of 2,2,7-trimethylguanosine caps, small nuclear ribonucleoprotein components, pre-mRNA splicing factors, and RNA decay pathways. The Journal of Biological Chemistry. 283: 31706-18. PMID 18775984 DOI: 10.1074/Jbc.M806127200  0.464
2008 Yan Z, Costanzo M, Heisler LE, Paw J, Kaper F, Andrews BJ, Boone C, Giaever G, Nislow C. Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers. Nature Methods. 5: 719-25. PMID 18622398 DOI: 10.1038/Nmeth.1231  0.562
2008 Dekker C, Stirling PC, McCormack EA, Filmore H, Paul A, Brost RL, Costanzo M, Boone C, Leroux MR, Willison KR. The interaction network of the chaperonin CCT Embo Journal. 27: 1827-1839. PMID 18511909 DOI: 10.1038/Emboj.2008.108  0.485
2008 Musso G, Costanzo M, Huangfu M, Smith AM, Paw J, San Luis BJ, Boone C, Giaever G, Nislow C, Emili A, Zhang Z. The extensive and condition-dependent nature of epistasis among whole-genome duplicates in yeast. Genome Research. 18: 1092-9. PMID 18463300 DOI: 10.1101/Gr.076174.108  0.46
2008 Zhao R, Kakihara Y, Gribun A, Huen J, Yang G, Khanna M, Costanzo M, Brost RL, Boone C, Hughes TR, Yip CM, Houry WA. Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation. The Journal of Cell Biology. 180: 563-78. PMID 18268103 DOI: 10.1083/Jcb.200709061  0.337
2008 Amaro IA, Costanzo M, Boone C, Huffaker TC. The Saccharomyces cerevisiae homolog of p24 is essential for maintaining the association of p150Glued with the dynactin complex. Genetics. 178: 703-9. PMID 18245366 DOI: 10.1534/Genetics.107.079103  0.437
2007 Jain S, Stanford N, Bhagwat N, Seiler B, Costanzo M, Boone C, Oelkers P. Identification of a novel lysophospholipid acyltransferase in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 282: 30562-9. PMID 17726007 DOI: 10.1074/Jbc.M706326200  0.342
2006 Costanzo M, Giaever G, Nislow C, Andrews B. Experimental approaches to identify genetic networks. Current Opinion in Biotechnology. 17: 472-80. PMID 16962766 DOI: 10.1016/J.Copbio.2006.08.005  0.603
2004 Costanzo M, Nishikawa JL, Tang X, Millman JS, Schub O, Breitkreuz K, Dewar D, Rupes I, Andrews B, Tyers M. CDK activity antagonizes Whi5, an inhibitor of G1/S transcription in yeast. Cell. 117: 899-913. PMID 15210111 DOI: 10.1016/J.Cell.2004.05.024  0.575
2003 Costanzo M, Schub O, Andrews B. G1 Transcription Factors Are Differentially Regulated in Saccharomyces cerevisiae by the Swi6-Binding Protein Stb1 Molecular and Cellular Biology. 23: 5064-5077. PMID 12832490 DOI: 10.1128/Mcb.23.14.5064-5077.2003  0.654
1999 Ho Y, Costanzo M, Moore L, Kobayashi R, Andrews BJ. Regulation of transcription at the Saccharomyces cerevisiae start transition by Stb1, a Swi6-binding protein. Molecular and Cellular Biology. 19: 5267-78. PMID 10409718 DOI: 10.1128/Mcb.19.8.5267  0.622
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