Douglas C. Rees - Publications

Affiliations: 
California Institute of Technology, Pasadena, CA 
Area:
Protein Structure and Energetics; X-ray Crystallography
Website:
http://www.hhmi.org/research/investigators/rees_bio.html

298 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Kuznetsova A, Masrati G, Vigonsky E, Livnat-Levanon N, Rose J, Grupper M, Baloum A, Yang JG, Rees DC, Ben-Tal N, Lewinson O. Titratable transmembrane residues and a hydrophobic plug are essential for manganese import via the Bacillus anthracis ABC transporter MntBC-A. The Journal of Biological Chemistry. 101087. PMID 34416234 DOI: 10.1016/j.jbc.2021.101087  1
2021 Sharaf NG, Shahgholi M, Kim E, Lai JY, VanderVelde DG, Lee AT, Rees DC. Characterization of the ABC methionine transporter from reveals that lipidated MetQ is required for interaction. Elife. 10. PMID 34409939 DOI: 10.7554/eLife.69742  1
2021 Probst C, Yang J, Krausze J, Hercher TW, Richers CP, Spatzal T, Kc K, Giles LJ, Rees DC, Mendel RR, Kirk ML, Kruse T. Mechanism of molybdate insertion into pterin-based molybdenum cofactors. Nature Chemistry. PMID 34183818 DOI: 10.1038/s41557-021-00714-1  1
2021 Cho HJ, Kim KS, Kim H, Kim T, Malyutin AG, Rees DC, Yoo BK, Song C. Microcrystal Electron Diffraction Elucidates Water-Specific Polymorphism-Induced Emission Enhancement of Bis-arylacylhydrazone. Acs Applied Materials & Interfaces. PMID 33544590 DOI: 10.1021/acsami.0c21248  0.16
2020 Buscagan TM, Perez KA, Maggiolo AO, Rees DC, Spatzal T. Structural Characterization of Two CO Molecules Bound to the Nitrogenase Active Site. Angewandte Chemie (International Ed. in English). PMID 33320413 DOI: 10.1002/anie.202015751  1
2020 Fan C, Rees DC. Crystal structure of the Escherichia coli transcription termination factor Rho. Acta Crystallographica. Section F, Structural Biology Communications. 76: 398-405. PMID 32880587 DOI: 10.1107/S2053230X20010572  1
2020 Fan C, Kaiser JT, Rees DC. A structural framework for unidirectional transport by a bacterial ABC exporter. Proceedings of the National Academy of Sciences of the United States of America. PMID 32703810 DOI: 10.1073/Pnas.2006526117  1
2020 Einsle O, Rees DC. Structural Enzymology of Nitrogenase Enzymes. Chemical Reviews. 120: 4969-5004. PMID 32538623 DOI: 10.1021/Acs.Chemrev.0C00067  1
2019 Buscagan TM, Rees DC. Rethinking the Nitrogenase Mechanism: Activating the Active Site. Joule. 3: 2662-2678. PMID 32864580 DOI: 10.1016/J.Joule.2019.09.004  1
2019 Henthorn JT, Arias RJ, Koroidov S, Kroll T, Sokaras D, Bergmann U, Rees DC, DeBeer S. Localized Electronic Structure of Nitrogenase FeMoco Re-vealed by Selenium K-edge High Resolution X-ray Absorption Spectroscopy. Journal of the American Chemical Society. PMID 31356071 DOI: 10.1021/Jacs.9B06988  1
2019 Nguyen PT, Lai JY, Kaiser JT, Rees DC. Structures of the Neisseria meningitides methionine-binding protein MetQ in substrate-free form and bound to L- and D-methionine isomers. Protein Science : a Publication of the Protein Society. PMID 31348565 DOI: 10.1002/Pro.3694  1
2019 Wenke BB, Spatzal T, Rees DC. Site-Specific Oxidation State Assignments of the Irons in the [4Fe:4S] States of the Nitrogenase Fe-Protein. Angewandte Chemie (International Ed. in English). PMID 30698901 DOI: 10.1002/Anie.201813966  1
2019 Fisher AJ, Mendoza-Denton R, Patt C, Young I, Eppig A, Garrell RL, Rees DC, Nelson TW, Richards MA. Structure and belonging: Pathways to success for underrepresented minority and women PhD students in STEM fields. Plos One. 14: e0209279. PMID 30625173 DOI: 10.1371/Journal.Pone.0209279  0.08
2018 Nguyen PT, Lai JY, Lee AT, Kaiser JT, Rees DC. Noncanonical role for the binding protein in substrate uptake by the MetNI methionine ATP Binding Cassette (ABC) transporter. Proceedings of the National Academy of Sciences of the United States of America. PMID 30352853 DOI: 10.2210/Pdb6Cvl/Pdb  1
2018 Herrera N, Maksaev G, Haswell ES, Rees DC. Elucidating a role for the cytoplasmic domain in the Mycobacterium tuberculosis mechanosensitive channel of large conductance. Scientific Reports. 8: 14566. PMID 30275500 DOI: 10.1038/S41598-018-32536-6  1
2018 Arias RJ, Kaiser JT, Rees DC. The "speed limit" for macromolecular crystal growth. Protein Science : a Publication of the Protein Society. PMID 30056633 DOI: 10.1002/Pro.3491  1
2018 Clardy J, Rees DC. Decision letter: Redox-dependent rearrangements of the NiFeS cluster of carbon monoxide dehydrogenase Elife. DOI: 10.7554/Elife.39451.030  0.01
2017 Morrison CN, Spatzal T, Rees DC. Correction to Reversible Protonated Resting State of the Nitrogenase Active Site. Journal of the American Chemical Society. PMID 28949128 DOI: 10.1021/Jacs.7B09849  1
2017 Segal HM, Spatzal T, Hill MG, Udit AK, Rees DC. Electrochemical and Structural Characterization of Azotobacter vinelandii Flavodoxin II. Protein Science : a Publication of the Protein Society. PMID 28710816 DOI: 10.1002/Pro.3236  1
2017 Morrison CN, Spatzal T, Rees DC. Reversible Protonated Resting State of the Nitrogenase Active Site. Journal of the American Chemical Society. PMID 28692802 DOI: 10.1021/Jacs.7B05695  1
2016 Bavi N, Cortes DM, Cox CD, Rohde PR, Liu W, Deitmer JW, Bavi O, Strop P, Hill AP, Rees D, Corry B, Perozo E, Martinac B. The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels. Nature Communications. 7: 11984. PMID 27329693 DOI: 10.1038/Ncomms11984  1
2016 Spatzal T, Schlesier J, Burger EM, Sippel D, Zhang L, Andrade SL, Rees DC, Einsle O. Nitrogenase FeMoco investigated by spatially resolved anomalous dispersion refinement. Nature Communications. 7: 10902. PMID 26973151 DOI: 10.1038/Ncomms10902  1
2016 Palmer N, Peakman TM, Norton D, Rees DC. Design and synthesis of dihydroisoquinolones for fragment-based drug discovery (FBDD). Organic & Biomolecular Chemistry. PMID 26741115 DOI: 10.1039/c5ob02461g  1
2015 Hannemann A, Rees DC, Tewari S, Gibson JS. Cation Homeostasis in Red Cells From Patients With Sickle Cell Disease Heterologous for HbS and HbC (HbSC Genotype). Ebiomedicine. 2: 1669-76. PMID 26870793 DOI: 10.1016/j.ebiom.2015.09.026  1
2015 Spatzal T, Perez KA, Howard JB, Rees DC. Catalysis-dependent selenium incorporation and migration in the nitrogenase active site iron-molybdenum cofactor. Elife. 4. PMID 26673079 DOI: 10.7554/Elife.11620  1
2015 Heeney MM, Hoppe CC, Abboud MR, Inusa B, Kanter J, Ogutu B, Brown PB, Heath LE, Jakubowski JA, Zhou C, Zamoryakhin D, Agbenyega T, Colombatti R, Hassab HM, Nduba VN, ... ... Rees DC, et al. A Multinational Trial of Prasugrel for Sickle Cell Vaso-Occlusive Events. The New England Journal of Medicine. PMID 26644172 DOI: 10.1056/NEJMoa1512021  1
2015 Murray CW, Rees DC. Opportunity Knocks: Organic Chemistry for Fragment-Based Drug Discovery (FBDD). Angewandte Chemie (International Ed. in English). PMID 26526786 DOI: 10.1002/anie.201506783  1
2015 Hoppe CC, Styles L, Heath LE, Zhou C, Jakubowski JA, Winters KJ, Brown PB, Rees DC, Heeney MM. Design of the DOVE (Determining Effects of Platelet Inhibition on Vaso-Occlusive Events) Trial: A Global Phase 3 Double-Blind, Randomized, Placebo-Controlled, Multicenter Study of the Efficacy and Safety of Prasugrel in Pediatric Patients With Sickle Cell Anemia Utilizing a Dose Titration Strategy. Pediatric Blood & Cancer. PMID 26402148 DOI: 10.1002/pbc.25771  1
2015 Tewari S, Brousse V, Piel FB, Menzel S, Rees DC. Environmental determinants of severity in sickle cell disease. Haematologica. 100: 1108-16. PMID 26341524 DOI: 10.3324/haematol.2014.120030  1
2015 Fotiou E, Martin-Almedina S, Simpson MA, Lin S, Gordon K, Brice G, Atton G, Jeffery I, Rees DC, Mignot C, Vogt J, Homfray T, Snyder MP, Rockson SG, Jeffery S, et al. Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis. Nature Communications. 6: 8085. PMID 26333996 DOI: 10.1038/Ncomms9085  0.08
2015 Howard J, Inusa B, Liossi C, Jacob E, Murphy PB, Hart N, Gavlak J, Sahota S, Chorozoglou M, Nwosu C, Gwam M, Gupta A, Rees DC, Thein SL, Reading IC, et al. Prevention of Morbidity in sickle cell disease - qualitative outcomes, pain and quality of life in a randomised cross-over pilot trial of overnight supplementary oxygen and auto-adjusting continuous positive airways pressure (POMS2a): study protocol for a randomised controlled trial. Trials. 16: 376. PMID 26303626 DOI: 10.1186/S13063-015-0883-Y  1
2015 Chessari G, Buck IM, Day JE, Day PJ, Iqbal A, Johnson CN, Lewis EJ, Martins V, Miller D, Reader M, Rees DC, Rich SJ, Tamanini E, Vitorino M, Ward GA, et al. Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP. Journal of Medicinal Chemistry. PMID 26218264 DOI: 10.1021/acs.jmedchem.5b00706  1
2015 Reading E, Walton TA, Liko I, Marty MT, Laganowsky A, Rees DC, Robinson CV. The Effect of Detergent, Temperature, and Lipid on the Oligomeric State of MscL Constructs: Insights from Mass Spectrometry. Chemistry & Biology. 22: 593-603. PMID 26000747 DOI: 10.1016/J.Chembiol.2015.04.016  1
2015 Mattle D, Zhang L, Sitsel O, Pedersen LT, Moncelli MR, Tadini-Buoninsegni F, Gourdon P, Rees DC, Nissen P, Meloni G. A sulfur-based transport pathway in Cu+-ATPases. Embo Reports. 16: 728-40. PMID 25956886 DOI: 10.15252/Embr.201439927  1
2015 Rees DC. Powering Brain Power: GLUT1 and the Era of Structure Based Human Transporter Biology. National Science Review. 2: 3-4. PMID 25937992 DOI: 10.1093/Nsr/Nwu075  1
2015 De Montalembert M, Abboud MR, Fiquet A, Inati A, Lebensburger JD, Kaddah N, Mokhtar G, Piga A, Halasa N, Inusa B, Rees DC, Heath PT, Telfer P, Driscoll C, Al Hajjar S, et al. 13-valent pneumococcal conjugate vaccine (PCV13) is immunogenic and safe in children 6-17 years of age with sickle cell disease previously vaccinated with 23-valent pneumococcal polysaccharide vaccine (PPSV23): Results of a phase 3 study. Pediatric Blood & Cancer. 62: 1427-36. PMID 25810327 DOI: 10.1002/pbc.25502  1
2015 Nguyen PT, Li QW, Kadaba NS, Lai JY, Yang JG, Rees DC. The contribution of methionine to the stability of the Escherichia coli MetNIQ ABC transporter-substrate binding protein complex. Biological Chemistry. PMID 25803078 DOI: 10.1515/Hsz-2015-0131  1
2015 Marsden JT, Guppy S, Stein P, Cox TM, Badminton M, Gardiner T, Barth JH, Stewart MF, Rees DC. Audit of the Use of Regular Haem Arginate Infusions in Patients with Acute Porphyria to Prevent Recurrent Symptoms. Jimd Reports. 22: 57-65. PMID 25762493 DOI: 10.1007/8904_2015_411  0.01
2015 Rees DC, Thein SL, Osei A, Drasar E, Tewari S, Hannemann A, Gibson JS. The clinical significance of K-Cl cotransport activity in red cells of patients with HbSC disease. Haematologica. 100: 595-600. PMID 25749827 DOI: 10.3324/haematol.2014.120402  1
2015 Morrison CN, Hoy JA, Zhang L, Einsle O, Rees DC. Substrate pathways in the nitrogenase MoFe protein by experimental identification of small molecule binding sites. Biochemistry. 54: 2052-60. PMID 25710326 DOI: 10.1021/Bi501313K  1
2015 Yang JG, Rees DC. The allosteric regulatory mechanism of the Escherichia coli MetNI methionine ATP binding cassette (ABC) transporter. The Journal of Biological Chemistry. 290: 9135-40. PMID 25678706 DOI: 10.1074/Jbc.M114.603365  1
2015 Zhang LM, Morrison CN, Kaiser JT, Rees DC. Nitrogenase MoFe protein from Clostridium pasteurianum at 1.08 Å resolution: comparison with the Azotobacter vinelandii MoFe protein. Acta Crystallographica. Section D, Biological Crystallography. 71: 274-82. PMID 25664737 DOI: 10.1107/S1399004714025243  1
2015 Johnson CN, Adelinet C, Berdini V, Beke L, Bonnet P, Brehmer D, Calo F, Coyle JE, Day PJ, Frederickson M, Freyne EJ, Gilissen RA, Hamlett CC, Howard S, Meerpoel L, ... ... Rees DC, et al. Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase. Acs Medicinal Chemistry Letters. 6: 31-6. PMID 25589926 DOI: 10.1021/ml5001273  1
2015 Johnson CN, Berdini V, Beke L, Bonnet P, Brehmer D, Coyle JE, Day PJ, Frederickson M, Freyne EJ, Gilissen RA, Hamlett CC, Howard S, Meerpoel L, McMenamin R, Patel S, ... Rees DC, et al. Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase. Acs Medicinal Chemistry Letters. 6: 25-30. PMID 25589925 DOI: 10.1021/ml5001245  1
2015 Tezcan FA, Kaiser JT, Howard JB, Rees DC. Structural evidence for asymmetrical nucleotide interactions in nitrogenase. Journal of the American Chemical Society. 137: 146-9. PMID 25522159 DOI: 10.1021/Ja511945E  1
2015 Walton TA, Idigo CA, Herrera N, Rees DC. MscL: channeling membrane tension. PflüGers Archiv : European Journal of Physiology. 467: 15-25. PMID 24859800 DOI: 10.1007/S00424-014-1535-X  1
2015 Spatzal T, Perez KA, Howard JB, Rees DC. Author response: Catalysis-dependent selenium incorporation and migration in the nitrogenase active site iron-molybdenum cofactor Elife. DOI: 10.7554/Elife.11620.023  1
2015 Fotiou E, Martin-Almedina S, Simpson MA, Lin S, Gordon K, Brice G, Atton G, Jeffery I, Rees DC, Mignot C, Vogt J, Homfray T, Snyder MP, Rockson SG, Jeffery S, et al. Novel mutations in PIEZO1 cause an autosomal recessive generalized lymphatic dysplasia with non-immune hydrops fetalis Nature Communications. 6. DOI: 10.1038/ncomms9085  1
2014 Spatzal T, Perez KA, Einsle O, Howard JB, Rees DC. Ligand binding to the FeMo-cofactor: structures of CO-bound and reactivated nitrogenase. Science (New York, N.Y.). 345: 1620-3. PMID 25258081 DOI: 10.1126/Science.1256679  1
2014 Kamajaya A, Kaiser JT, Lee J, Reid M, Rees DC. The structure of a conserved piezo channel domain reveals a topologically distinct β sandwich fold. Structure (London, England : 1993). 22: 1520-7. PMID 25242456 DOI: 10.1016/J.Str.2014.08.009  1
2014 Wang K, Sitsel O, Meloni G, Autzen HE, Andersson M, Klymchuk T, Nielsen AM, Rees DC, Nissen P, Gourdon P. Structure and mechanism of Zn2+-transporting P-type ATPases. Nature. 514: 518-22. PMID 25132545 DOI: 10.1038/Nature13618  1
2014 Hannemann A, Cytlak UM, Rees DC, Tewari S, Gibson JS. Effects of 5-hydroxymethyl-2-furfural on the volume and membrane permeability of red blood cells from patients with sickle cell disease. The Journal of Physiology. 592: 4039-49. PMID 25015917 DOI: 10.1113/jphysiol.2014.277681  1
2014 Wykes C, Arasaretnam A, O'Driscoll S, Farnham L, Moniz C, Rees DC. Vitamin D deficiency and its correction in children with sickle cell anaemia. Annals of Hematology. 93: 2051-6. PMID 24981689 DOI: 10.1007/s00277-014-2144-7  1
2014 Murray CW, Erlanson DA, Hopkins AL, Keserü GM, Leeson PD, Rees DC, Reynolds CH, Richmond NJ. Validity of ligand efficiency metrics. Acs Medicinal Chemistry Letters. 5: 616-8. PMID 24944729 DOI: 10.1021/ml500146d  1
2014 Brousse V, Makani J, Rees DC. Management of sickle cell disease in the community. Bmj (Clinical Research Ed.). 348: g1765. PMID 24613806 DOI: 10.1136/bmj.g1765  1
2014 Lee JY, Yang JG, Zhitnitsky D, Lewinson O, Rees DC. Structural basis for heavy metal detoxification by an Atm1-type ABC exporter. Science (New York, N.Y.). 343: 1133-6. PMID 24604198 DOI: 10.1126/Science.1246489  1
2014 Hannemann A, Cytlak UM, Gbotosho OT, Rees DC, Tewari S, Gibson JS. Effects of o-vanillin on K⁺ transport of red blood cells from patients with sickle cell disease. Blood Cells, Molecules & Diseases. 53: 21-6. PMID 24594314 DOI: 10.1016/j.bcmd.2014.02.004  1
2014 Hopkins AL, Keserü GM, Leeson PD, Rees DC, Reynolds CH. The role of ligand efficiency metrics in drug discovery. Nature Reviews. Drug Discovery. 13: 105-21. PMID 24481311 DOI: 10.1038/nrd4163  1
2014 Yang KY, Haynes CA, Spatzal T, Rees DC, Howard JB. Turnover-dependent inactivation of the nitrogenase MoFe-protein at high pH. Biochemistry. 53: 333-43. PMID 24392967 DOI: 10.1021/Bi4014769  1
2014 Basta T, Wu HJ, Morphew MK, Lee J, Ghosh N, Lai J, Heumann JM, Wang K, Lee YC, Rees DC, Stowell MH. Self-assembled lipid and membrane protein polyhedral nanoparticles. Proceedings of the National Academy of Sciences of the United States of America. 111: 670-4. PMID 24379376 DOI: 10.1073/Pnas.1321936111  1
2014 Spackman E, Sculpher M, Howard J, Malfroy M, Llewelyn C, Choo L, Hodge R, Johnson T, Rees DC, Fijnvandraat K, Kirby-Allen M, Davies S, Williamson L. Cost-effectiveness analysis of preoperative transfusion in patients with sickle cell disease using evidence from the TAPS trial. European Journal of Haematology. 92: 249-55. PMID 24329965 DOI: 10.1111/ejh.12232  1
2014 Gbotosho OT, Cytlak UM, Hannemann A, Rees DC, Tewari S, Gibson JS. Inhibitors of second messenger pathways and Ca(2+)-induced exposure of phosphatidylserine in red blood cells of patients with sickle cell disease. Pflã¼Gers Archiv : European Journal of Physiology. 466: 1477-85. PMID 24158429 DOI: 10.1007/s00424-013-1343-8  1
2014 Meloni G, Zhang L, Rees DC. Transmembrane type-2-like Cu2+ site in the P1B-3-type ATPase CopB: implications for metal selectivity. Acs Chemical Biology. 9: 116-21. PMID 24144006 DOI: 10.1021/Cb400603T  1
2014 Page C, Gardner K, Height S, Rees DC, Hampton T, Thein SL. Nontraumatic extradural hematoma in sickle cell anemia: a rare neurological complication not to be missed. American Journal of Hematology. 89: 225-7. PMID 24038013 DOI: 10.1002/ajh.23579  1
2014 Marsden JT, Rees DC. Urinary excretion of porphyrins, porphobilinogen and δ-aminolaevulinic acid following an attack of acute intermittent porphyria. Journal of Clinical Pathology. 67: 60-5. PMID 23908454 DOI: 10.1136/jclinpath-2012-201367  1
2014 Piel FB, Rees DC, Williams TN. Managing the burden of sickle-cell disease in Africa The Lancet Haematology. 1: e11-e12.  1
2013 Rees DGC, Phillpotts RJ, Griffin KF, Lukaszewski RA, Laws TR, Atkins HS, Krieg AM, Titball RW. CpG oligonucleotides protect against Venezuelan equine encephalitis virus infection in a route-dependent manner International Journal of Antimicrobial Agents. 42: 587-588. PMID 24210643 DOI: 10.1016/j.ijantimicag.2013.09.001  1
2013 Walton TA, Rees DC. Structure and stability of the C-terminal helical bundle of the E. coli mechanosensitive channel of large conductance. Protein Science : a Publication of the Protein Society. 22: 1592-601. PMID 24038743 DOI: 10.1002/Pro.2360  1
2013 Howard JB, Kechris KJ, Rees DC, Glazer AN. Multiple amino acid sequence alignment nitrogenase component 1: insights into phylogenetics and structure-function relationships. Plos One. 8: e72751. PMID 24019874 DOI: 10.1371/Journal.Pone.0072751  1
2013 Zhang L, Kaiser JT, Meloni G, Yang KY, Spatzal T, Andrade SL, Einsle O, Howard JB, Rees DC. The sixteenth iron in the nitrogenase MoFe protein. Angewandte Chemie (International Ed. in English). 52: 10529-32. PMID 23963815 DOI: 10.1002/Anie.201303877  1
2013 Jhoti H, Williams G, Rees DC, Murray CW. The 'rule of three' for fragment-based drug discovery: where are we now? Nature Reviews. Drug Discovery. 12: 644-5. PMID 23845999 DOI: 10.1038/nrd3926-c1  1
2013 Cytlak UM, Hannemann A, Rees DC, Gibson JS. Identification of the Ca²⁺ entry pathway involved in deoxygenation-induced phosphatidylserine exposure in red blood cells from patients with sickle cell disease. Pflã¼Gers Archiv : European Journal of Physiology. 465: 1651-60. PMID 23775402 DOI: 10.1007/s00424-013-1308-y  1
2013 Rees DG, Hartley MG, Green M, Lukaszewski RA, Griffin KF, Atkins HS, Lyons R, Krieg AM, Titball RW. The ability of CpG oligonucleotides to protect mice against Francisella tularensis live vaccine strain but not fully virulent F. tularensis subspecies holarctica is reflected in cell-based assays. Microbial Pathogenesis. 63: 16-8. PMID 23707360 DOI: 10.1016/j.micpath.2013.04.013  1
2013 Pieper U, Schlessinger A, Kloppmann E, Chang GA, Chou JJ, Dumont ME, Fox BG, Fromme P, Hendrickson WA, Malkowski MG, Rees DC, Stokes DL, Stowell MH, Wiener MC, Rost B, et al. Coordinating the impact of structural genomics on the human α-helical transmembrane proteome. Nature Structural & Molecular Biology. 20: 135-8. PMID 23381628 DOI: 10.1038/Nsmb.2508  1
2013 Howard J, Malfroy M, Llewelyn C, Choo L, Hodge R, Johnson T, Purohit S, Rees DC, Tillyer L, Walker I, Fijnvandraat K, Kirby-Allen M, Spackman E, Davies SC, Williamson LM. The Transfusion Alternatives Preoperatively in Sickle Cell Disease (TAPS) study: a randomised, controlled, multicentre clinical trial. Lancet. 381: 930-8. PMID 23352054 DOI: 10.1016/S0140-6736(12)61726-7  1
2013 Lai JY, Poon YS, Kaiser JT, Rees DC. Open and shut: crystal structures of the dodecylmaltoside solubilized mechanosensitive channel of small conductance from Escherichia coli and Helicobacter pylori at 4.4 Ã… and 4.1 Ã… resolutions. Protein Science : a Publication of the Protein Society. 22: 502-9. PMID 23339071 DOI: 10.1002/Pro.2222  1
2013 Milligan C, Rees DC, Ellory JC, Osei A, Browning JA, Hannemann A, Gibson JS. A non-electrolyte haemolysis assay for diagnosis and prognosis of sickle cell disease. The Journal of Physiology. 591: 1463-74. PMID 23297308 DOI: 10.1113/jphysiol.2012.246579  1
2013 Benton CM, Couchman L, Marsden JT, Rees DC, Moniz C, Lim CK. Direct and simultaneous quantitation of 5-aminolaevulinic acid and porphobilinogen in human serum or plasma by hydrophilic interaction liquid chromatography-atmospheric pressure chemical ionization/tandem mass spectrometry. Biomedical Chromatography : Bmc. 27: 267-72. PMID 23180457 DOI: 10.1002/bmc.2843  1
2013 Brousse V, Gandhi S, de Montalembert M, Height S, Dick MC, O'Driscoll S, Abihsera G, Rees DC. Combined blood transfusion and hydroxycarbamide in children with sickle cell anaemia. British Journal of Haematology. 160: 259-61. PMID 23116405 DOI: 10.1111/bjh.12104  1
2013 Wu HJ, Basta T, Morphew M, Rees DC, Stowell MHB, Lee YC. Microfluidic device for super-fast evaluation of membrane protein crystallization 8th Annual Ieee International Conference On Nano/Micro Engineered and Molecular Systems, Ieee Nems 2013. 84-87. DOI: 10.1109/NEMS.2013.6559687  1
2013 Wu HJ, Basta T, Morphew M, Rees DC, Stowell MHB, Lee YC. Microfluidic device for super-fast evaluation of membrane protein nanoparticle formation Micro and Nano Letters. 8: 672-675. DOI: 10.1049/Mnl.2013.0216  1
2013 Streetly A, Rees DC. Newborn screening for haematological disorders Paediatrics and Child Health (United Kingdom). 23: 472-479. DOI: 10.1016/j.paed.2013.03.001  1
2013 Rees DC. Blood Transfusion in the Management of Patients with Haemoglobinopathies Practical Transfusion Medicine. 314-321. DOI: 10.1002/9781118520093.ch29  1
2012 Cho YS, Angove H, Brain C, Chen CH, Cheng H, Cheng R, Chopra R, Chung K, Congreve M, Dagostin C, Davis DJ, Feltell R, Giraldes J, Hiscock SD, Kim S, ... ... Rees DC, et al. Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors. Acs Medicinal Chemistry Letters. 3: 445-9. PMID 24900493 DOI: 10.1021/ml200241a  1
2012 Cherry MG, Greenhalgh J, Osipenko L, Venkatachalam M, Boland A, Dundar Y, Marsh K, Dickson R, Rees DC. The clinical effectiveness and cost-effectiveness of primary stroke prevention in children with sickle cell disease: a systematic review and economic evaluation. Health Technology Assessment (Winchester, England). 16: 1-129. PMID 23140544 DOI: 10.3310/hta16430  1
2012 Stein PE, Badminton MN, Barth JH, Rees DC, Sarkany R, Stewart MF, Cox TM. Acute intermittent porphyria: fatal complications of treatment. Clinical Medicine (London, England). 12: 293-4. PMID 22783787 DOI: 10.7861/Clinmedicine.12-3-293  1
2012 Benton CM, Couchman L, Marsden JT, Rees DC, Moniz C, Lim CK. Direct and simultaneous determination of 5-aminolaevulinic acid and porphobilinogen in urine by hydrophilic interaction liquid chromatography-electrospray ionisation/tandem mass spectrometry. Biomedical Chromatography : Bmc. 26: 1033-40. PMID 22740490 DOI: 10.1002/bmc.2770  1
2012 Murray CW, Verdonk ML, Rees DC. Experiences in fragment-based drug discovery. Trends in Pharmacological Sciences. 33: 224-32. PMID 22459076 DOI: 10.1016/j.tips.2012.02.006  1
2012 Ma YL, Rees DC, Gibson JS, Ellory JC. The conductance of red blood cells from sickle cell patients: ion selectivity and inhibitors. The Journal of Physiology. 590: 2095-105. PMID 22411011 DOI: 10.1113/jphysiol.2012.229609  1
2012 Weiss E, Cytlak UM, Rees DC, Osei A, Gibson JS. Deoxygenation-induced and Ca(2+) dependent phosphatidylserine externalisation in red blood cells from normal individuals and sickle cell patients. Cell Calcium. 51: 51-6. PMID 22197026 DOI: 10.1016/j.ceca.2011.10.005  1
2012 Rees DC, Gibson JS. Biomarkers in sickle cell disease. British Journal of Haematology. 156: 433-45. PMID 22122125 DOI: 10.1111/j.1365-2141.2011.08961.x  1
2012 Johnson E, Nguyen PT, Yeates TO, Rees DC. Inward facing conformations of the MetNI methionine ABC transporter: Implications for the mechanism of transinhibition. Protein Science : a Publication of the Protein Society. 21: 84-96. PMID 22095702 DOI: 10.1002/Pro.765  1
2012 Bobyr E, Lassila JK, Wiersma-Koch HI, Fenn TD, Lee JJ, Nikolic-Hughes I, Hodgson KO, Rees DC, Hedman B, Herschlag D. High-resolution analysis of Zn(2+) coordination in the alkaline phosphatase superfamily by EXAFS and x-ray crystallography. Journal of Molecular Biology. 415: 102-17. PMID 22056344 DOI: 10.1016/J.Jmb.2011.10.040  1
2011 Spatzal T, Aksoyoglu M, Zhang L, Andrade SL, Schleicher E, Weber S, Rees DC, Einsle O. Evidence for interstitial carbon in nitrogenase FeMo cofactor. Science (New York, N.Y.). 334: 940. PMID 22096190 DOI: 10.1126/Science.1214025  1
2011 Tirado-Lee L, Lee A, Rees DC, Pinkett HW. Classification of a Haemophilus influenzae ABC transporter HI1470/71 through its cognate molybdate periplasmic binding protein, MolA. Structure (London, England : 1993). 19: 1701-10. PMID 22078568 DOI: 10.1016/J.Str.2011.10.004  1
2011 Haswell ES, Phillips R, Rees DC. Mechanosensitive channels: what can they do and how do they do it? Structure (London, England : 1993). 19: 1356-69. PMID 22000509 DOI: 10.1016/J.Str.2011.09.005  1
2011 Day TG, Thein SL, Drasar E, Dick MC, Height SE, O'Driscoll S, Rees DC. Changing pattern of hospital admissions of children with sickle cell disease over the last 50 years. Journal of Pediatric Hematology/Oncology. 33: 491-5. PMID 21941140 DOI: 10.1097/MPH.0b013e31822543f4  1
2011 Wykes C, Rees DC. The safety and efficacy of hydroxycarbamide in infants with sickle cell anemia. Expert Review of Hematology. 4: 407-9. PMID 21801131 DOI: 10.1586/ehm.11.40  1
2011 Weiss E, Rees DC, Gibson JS. Role of calcium in phosphatidylserine externalisation in red blood cells from sickle cell patients. Anemia. 2011: 379894. PMID 21490763 DOI: 10.1155/2011/379894  1
2011 Hannemann A, Weiss E, Rees DC, Dalibalta S, Ellory JC, Gibson JS. The Properties of Red Blood Cells from Patients Heterozygous for HbS and HbC (HbSC Genotype). Anemia. 2011: 248527. PMID 21490760 DOI: 10.1155/2011/248527  1
2011 Rees DC. The rationale for using hydroxycarbamide in the treatment of sickle cell disease. Haematologica. 96: 488-91. PMID 21454878 DOI: 10.3324/haematol.2011.041988  1
2011 Moller HJ, Nielsen MJ, Bartram J, Dick MC, Height SE, Moestrup SK, Rees DC. Soluble CD163 levels in children with sickle cell disease. British Journal of Haematology. 153: 105-10. PMID 21332709 DOI: 10.1111/j.1365-2141.2011.08580.x  1
2011 Gandhi CS, Walton TA, Rees DC. OCAM: a new tool for studying the oligomeric diversity of MscL channels. Protein Science : a Publication of the Protein Society. 20: 313-26. PMID 21280123 DOI: 10.1002/Pro.562  1
2011 Kaiser JT, Hu Y, Wiig JA, Rees DC, Ribbe MW. Structure of precursor-bound NifEN: a nitrogenase FeMo cofactor maturase/insertase. Science (New York, N.Y.). 331: 91-4. PMID 21212358 DOI: 10.1126/Science.1196954  1
2011 de Montalembert M, Ferster A, Colombatti R, Rees DC, Gulbis B. ENERCA clinical recommendations for disease management and prevention of complications of sickle cell disease in children. American Journal of Hematology. 86: 72-5. PMID 20981677 DOI: 10.1002/ajh.21865  1
2011 Bartram JL, O'Driscoll S, Kulasekararaj AG, Height SE, Dick M, Patel S, Rees DC. Portacaths are safe for long-term regular blood transfusion in children with sickle cell anaemia. Archives of Disease in Childhood. 96: 1082-4. PMID 20605863 DOI: 10.1136/adc.2009.173856  1
2011 Parkar AAH, Annapureddy SR, Rees DC, Eastwood DM, Pringle J. Giant infantile plexiform cellular schwannoma of the knee Diagnostic Histopathology. 17: 203-205. DOI: 10.1016/j.mpdhp.2011.01.002  1
2010 Rees DC, Williams TN, Gladwin MT. Sickle-cell disease. Lancet (London, England). 376: 2018-31. PMID 21131035 DOI: 10.1016/S0140-6736(10)61029-X  1
2010 Woodhead AJ, Angove H, Carr MG, Chessari G, Congreve M, Coyle JE, Cosme J, Graham B, Day PJ, Downham R, Fazal L, Feltell R, Figueroa E, Frederickson M, Lewis J, ... ... Rees DC, et al. Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design. Journal of Medicinal Chemistry. 53: 5956-69. PMID 20662534 DOI: 10.1021/jm100060b  1
2010 Marsden JT, Rees DC. A retrospective analysis of outcome of pregnancy in patients with acute porphyria. Journal of Inherited Metabolic Disease. 33: 591-6. PMID 20567908 DOI: 10.1007/s10545-010-9142-2  1
2010 Gardner K, Bell C, Bartram JL, Allman M, Awogbade M, Rees DC, Ervine M, Thein SL. Outcome of adults with sickle cell disease admitted to critical care - experience of a single institution in the UK. British Journal of Haematology. 150: 610-3. PMID 20560967 DOI: 10.1111/j.1365-2141.2010.08271.x  1
2010 Bartram JL, Thein SL, Gardner K, Egberongbe Y, D'Silva P, Height SE, Dick MC, O'Driscoll S, Rees DC. Outcome of children with sickle cell disease admitted to intensive care - a single institution experience. British Journal of Haematology. 150: 614-7. PMID 20560966 DOI: 10.1111/j.1365-2141.2010.08272.x  1
2010 Fermo E, Bianchi P, Vercellati C, Rees DC, Marcello AP, Barcellini W, Zanella A. Triose phosphate isomerase deficiency associated with two novel mutations in TPI gene. European Journal of Haematology. 85: 170-3. PMID 20374271 DOI: 10.1111/j.1600-0609.2010.01451.x  1
2010 Inusa B, Zuckerman M, Gadong N, Afif M, Arnott S, Heath P, Marais G, Robertson P, Payne H, Wilkey O, Rees DC. Pandemic influenza A (H1N1) virus infections in children with sickle cell disease. Blood. 115: 2329-30. PMID 20299522 DOI: 10.1182/blood-2009-12-260836  1
2010 Dalibalta S, Ellory JC, Browning JA, Wilkins RJ, Rees DC, Gibson JS. Novel permeability characteristics of red blood cells from sickle cell patients heterozygous for HbS and HbC (HbSC genotype). Blood Cells, Molecules & Diseases. 45: 46-52. PMID 20227897 DOI: 10.1016/j.bcmd.2010.02.010  1
2010 Deane CR, Goss D, Bartram J, Pohl KR, Height SE, Sibtain N, Jarosz J, Thein SL, Rees DC. Extracranial internal carotid arterial disease in children with sickle cell anemia. Haematologica. 95: 1287-92. PMID 20220066 DOI: 10.3324/haematol.2010.022624  1
2010 Lewinson O, Lee AT, Locher KP, Rees DC. A distinct mechanism for the ABC transporter BtuCD-BtuF revealed by the dynamics of complex formation. Nature Structural & Molecular Biology. 17: 332-8. PMID 20173761 DOI: 10.1038/Nsmb.1770  1
2010 Liu Z, Walton TA, Rees DC. A reported archaeal mechanosensitive channel is a structural homolog of MarR-like transcriptional regulators. Protein Science : a Publication of the Protein Society. 19: 808-14. PMID 20162616 DOI: 10.1002/Pro.360  1
2010 Ryan K, Bain BJ, Worthington D, James J, Plews D, Mason A, Roper D, Rees DC, de la Salle B, Streetly A. Significant haemoglobinopathies: guidelines for screening and diagnosis. British Journal of Haematology. 149: 35-49. PMID 20067565 DOI: 10.1111/j.1365-2141.2009.08054.x  1
2010 Quek L, Sharpe C, Dutt N, Height S, Allman M, Awogbade M, Rees DC, Zuckerman M, Thein SL. Acute human parvovirus B19 infection and nephrotic syndrome in patients with sickle cell disease. British Journal of Haematology. 149: 289-91. PMID 20064150 DOI: 10.1111/j.1365-2141.2009.08062.x  1
2009 Murray CW, Rees DC. The rise of fragment-based drug discovery. Nature Chemistry. 1: 187-92. PMID 21378847 DOI: 10.1038/nchem.217  1
2009 Liu Z, Gandhi CS, Rees DC. Structure of a tetrameric MscL in an expanded intermediate state. Nature. 461: 120-4. PMID 19701184 DOI: 10.1038/Nature08277  1
2009 Rees DC, Lambert C, Cooper E, Bartram J, Goss D, Deane C, Thein SL. Glucose 6 phosphate dehydrogenase deficiency is not associated with cerebrovascular disease in children with sickle cell anemia. Blood. 114: 742-3; author reply . PMID 19608759 DOI: 10.1182/blood-2009-04-216861  1
2009 Marshall MJ, Bucks RS, Hogan AM, Hambleton IR, Height SE, Dick MC, Kirkham FJ, Rees DC. Auto-adjusting positive airway pressure in children with sickle cell anemia: results of a phase I randomized controlled trial. Haematologica. 94: 1006-10. PMID 19570752 DOI: 10.3324/haematol.2008.005215  1
2009 Roberts L, O'Driscoll S, Dick MC, Height SE, Deane C, Goss DE, Pohl K, Rees DC. Stroke prevention in the young child with sickle cell anaemia. Annals of Hematology. 88: 943-6. PMID 19455330 DOI: 10.1007/s00277-009-0757-z  1
2009 Lewinson O, Lee AT, Rees DC. A P-type ATPase importer that discriminates between essential and toxic transition metals. Proceedings of the National Academy of Sciences of the United States of America. 106: 4677-82. PMID 19264958 DOI: 10.1073/Pnas.0900666106  1
2009 Rees DC, Johnson E, Lewinson O. ABC transporters: the power to change. Nature Reviews. Molecular Cell Biology. 10: 218-27. PMID 19234479 DOI: 10.1038/Nrm2646  1
2009 Rice AE, Mendez MJ, Hokanson CA, Rees DC, Björkman PJ. Investigation of the biophysical and cell biological properties of ferroportin, a multipass integral membrane protein iron exporter. Journal of Molecular Biology. 386: 717-32. PMID 19150361 DOI: 10.1016/J.Jmb.2008.12.063  1
2009 Howard S, Berdini V, Boulstridge JA, Carr MG, Cross DM, Curry J, Devine LA, Early TR, Fazal L, Gill AL, Heathcote M, Maman S, Matthews JE, McMenamin RL, Navarro EF, ... ... Rees DC, et al. Fragment-based discovery of the pyrazol-4-yl urea (AT9283), a multitargeted kinase inhibitor with potent aurora kinase activity. Journal of Medicinal Chemistry. 52: 379-88. PMID 19143567 DOI: 10.1021/jm800984v  1
2009 Furness CL, O'Driscoll S, Davenport M, Morrison G, Height SE, Dick MC, Rees DC. Hydroxycarbamide and erythropoietin in the preoperative management of children with sickle cell anaemia undergoing moderate risk surgery. British Journal of Haematology. 144: 453-4. PMID 19036093 DOI: 10.1111/j.1365-2141.2008.07463.x  1
2009 Mittal H, Roberts L, Fuller GW, O'Driscoll S, Dick MC, Height SE, Thein SL, Rees DC. The effects of air quality on haematological and clinical parameters in children with sickle cell anaemia. Annals of Hematology. 88: 529-33. PMID 18769920 DOI: 10.1007/s00277-008-0598-1  1
2009 Roberts LN, Rees DC. Neonatal screening for haematological disorders Paediatrics and Child Health. 19: 372-376. DOI: 10.1016/j.paed.2009.04.002  1
2009 Rees DC, Walejeski W, Herzau J, Spiegel D. Advanced pattern recognition and automated assessment technologies 6th American Nuclear Society International Topical Meeting On Nuclear Plant Instrumentation, Control, and Human-Machine Interface Technologies 2009. 2: 712-722.  1
2008 Gandhi CS, Rees DC. Biochemistry. Opening the molecular floodgates. Science (New York, N.Y.). 321: 1166-7. PMID 18755963 DOI: 10.1126/Science.1162963  1
2008 Verdonk ML, Rees DC. Group efficiency: a guideline for hits-to-leads chemistry. Chemmedchem. 3: 1179-80. PMID 18651625 DOI: 10.1002/cmdc.200800132  1
2008 Kadaba NS, Kaiser JT, Johnson E, Lee A, Rees DC. The high-affinity E. coli methionine ABC transporter: structure and allosteric regulation. Science (New York, N.Y.). 321: 250-3. PMID 18621668 DOI: 10.1126/Science.1157987  1
2008 Ulug P, Vasavda N, Kumar R, Keir L, Awogbade M, Cunningham J, Rees DC, Menzel S, Thein SL. Hydroxyurea therapy lowers circulating DNA levels in sickle cell anemia. American Journal of Hematology. 83: 714-6. PMID 18615556 DOI: 10.1002/ajh.21237  1
2008 Rees DC, Dick MC, Height SE, O'Driscoll S, Pohl KR, Goss DE, Deane CR. A simple index using age, hemoglobin, and aspartate transaminase predicts increased intracerebral blood velocity as measured by transcranial Doppler scanning in children with sickle cell anemia. Pediatrics. 121: e1628-32. PMID 18490379 DOI: 10.1542/peds.2007-2771  1
2008 Lewinson O, Lee AT, Rees DC. The funnel approach to the precrystallization production of membrane proteins. Journal of Molecular Biology. 377: 62-73. PMID 18241890 DOI: 10.1016/J.Jmb.2007.12.059  1
2008 O'Driscoll S, Height SE, Dick MC, Rees DC. Serum lactate dehydrogenase activity as a biomarker in children with sickle cell disease. British Journal of Haematology. 140: 206-9. PMID 18028483 DOI: 10.1111/j.1365-2141.2007.06894.x  1
2008 Deane CR, Goss D, O'Driscoll S, Mellor S, Pohl KR, Dick MC, Height SE, Rees DC. Transcranial Doppler scanning and the assessment of stroke risk in children with HbSC [corrected] disease. Archives of Disease in Childhood. 93: 138-41. PMID 17925326 DOI: 10.1136/adc.2007.125799  1
2008 Rees DC. Annual Review of Biophysics and Biomolecular Structure: Preface Annual Review of Biophysics. 37: v-vi.  1
2007 Vasavda N, Ulug P, Kondaveeti S, Ramasamy K, Sugai T, Cheung G, Rees DC, Awogbade M, Bannister S, Cunningham J, Menzel S, Thein SL. Circulating DNA: a potential marker of sickle cell crisis. British Journal of Haematology. 139: 331-6. PMID 17897311 DOI: 10.1111/j.1365-2141.2007.06775.x  1
2007 O'Donnell A, Premawardhena A, Arambepola M, Allen SJ, Peto TE, Fisher CA, Rees DC, Olivieri NF, Weatherall DJ. Age-related changes in adaptation to severe anemia in childhood in developing countries. Proceedings of the National Academy of Sciences of the United States of America. 104: 9440-4. PMID 17517643 DOI: 10.1073/pnas.0703424104  1
2007 Yallop D, Duncan ER, Norris E, Fuller GW, Thomas N, Walters J, Dick MC, Height SE, Thein SL, Rees DC. The associations between air quality and the number of hospital admissions for acute pain and sickle-cell disease in an urban environment. British Journal of Haematology. 136: 844-8. PMID 17341271 DOI: 10.1111/j.1365-2141.2007.06493.x  1
2007 Einsle O, Andrade SL, Dobbek H, Meyer J, Rees DC. Assignment of individual metal redox states in a metalloprotein by crystallographic refinement at multiple X-ray wavelengths. Journal of the American Chemical Society. 129: 2210-1. PMID 17269774 DOI: 10.1021/Ja067562O  1
2007 Pinkett HW, Lee AT, Lum P, Locher KP, Rees DC. An inward-facing conformation of a putative metal-chelate-type ABC transporter. Science (New York, N.Y.). 315: 373-7. PMID 17158291 DOI: 10.1126/Science.1133488  1
2007 Gerovassili A, Garner C, Nicolaides KH, Thein SL, Rees DC. Free fetal DNA in maternal circulation: a potential prognostic marker for chromosomal abnormalities? Prenatal Diagnosis. 27: 104-10. PMID 17152117 DOI: 10.1002/pd.1607  1
2007 Steinbacher S, Bass R, Strop P, Rees DC. Structures of the Prokaryotic Mechanosensitive Channels MscL and MscS Current Topics in Membranes. 58: 1-24. DOI: 10.1016/S1063-5823(06)58001-9  1
2007 Congreve M, Murray CW, Carr R, Rees DC. Chapter 28 Fragment-Based Lead Discovery Annual Reports in Medicinal Chemistry. 42: 431-448. DOI: 10.1016/S0065-7743(07)42028-0  1
2007 Salem K, Rees DC, Geutjens G. Low velocity bicondylar tibial fracture following ACL reconstruction Injury Extra. 38: 179-181. DOI: 10.1016/j.injury.2006.08.065  1
2006 Gerovassili A, Nicolaides KH, Thein SL, Rees DC. Cell-free DNA levels in pregnancies at risk of sickle-cell disease and significant ethnic variation. British Journal of Haematology. 135: 738-41. PMID 17107357 DOI: 10.1111/j.1365-2141.2006.06357.x  1
2006 Howard JB, Rees DC. How many metals does it take to fix N2? A mechanistic overview of biological nitrogen fixation. Proceedings of the National Academy of Sciences of the United States of America. 103: 17088-93. PMID 17088547 DOI: 10.1073/Pnas.0603978103  1
2006 Kirkham FJ, Lerner NB, Noetzel M, DeBaun MR, Datta AK, Rees DC, Adams RJ. Trials in sickle cell disease. Pediatric Neurology. 34: 450-8. PMID 16765823 DOI: 10.1016/j.pediatrneurol.2005.10.017  1
2005 Poolman B, Doeven MK, Geertsma ER, Biemans-Oldehinkel E, Konings WN, Rees DC. Functional analysis of detergent-solubilized and membrane-reconstituted ATP-binding cassette transporters. Methods in Enzymology. 400: 429-59. PMID 16399364 DOI: 10.1016/S0076-6879(05)00025-X  1
2005 Borths EL, Poolman B, Hvorup RN, Locher KP, Rees DC. In vitro functional characterization of BtuCD-F, the Escherichia coli ABC transporter for vitamin B12 uptake. Biochemistry. 44: 16301-9. PMID 16331991 DOI: 10.1021/Bi0513103  1
2005 Jones S, Duncan ER, Thomas N, Walters J, Dick MC, Height SE, Stephens AD, Thein SL, Rees DC. Windy weather and low humidity are associated with an increased number of hospital admissions for acute pain and sickle cell disease in an urban environment with a maritime temperate climate. British Journal of Haematology. 131: 530-3. PMID 16281945 DOI: 10.1111/j.1365-2141.2005.05799.x  1
2005 Tezcan FA, Kaiser JT, Mustafi D, Walton MY, Howard JB, Rees DC. Nitrogenase complexes: multiple docking sites for a nucleotide switch protein. Science (New York, N.Y.). 309: 1377-80. PMID 16123301 DOI: 10.1126/Science.1115653  1
2005 Rees DC, Iolascon A, Carella M, O'Marcaigh AS, Kendra JR, Jowitt SN, Wales JK, Vora A, Makris M, Manning N, Nicolaou A, Fisher J, Mann A, Machin SJ, Clayton PT, et al. Stomatocytic haemolysis and macrothrombocytopenia (Mediterranean stomatocytosis/macrothrombocytopenia) is the haematological presentation of phytosterolaemia British Journal of Haematology. 130: 297-309. PMID 16029460 DOI: 10.1111/j.1365-2141.2005.05599.x  1
2005 Carr RA, Congreve M, Murray CW, Rees DC. Fragment-based lead discovery: leads by design. Drug Discovery Today. 10: 987-92. PMID 16023057 DOI: 10.1016/S1359-6446(05)03511-7  1
2005 Dalton RN, Turner C, Dick M, Height SE, Awogbade M, Inusa B, Okpala I, O'Driscoll S, Thein SL, Rees DC. The measurement of urinary hydroxyurea in sickle cell anaemia British Journal of Haematology. 130: 138-144. PMID 15982356 DOI: 10.1111/j.1365-2141.2005.05583.x  1
2005 Andrade SL, Cruz F, Drennan CL, Ramakrishnan V, Rees DC, Ferry JG, Einsle O. Structures of the iron-sulfur flavoproteins from Methanosarcina thermophila and Archaeoglobus fulgidus. Journal of Bacteriology. 187: 3848-54. PMID 15901710 DOI: 10.1128/Jb.187.11.3848-3854.2005  1
2005 Rees DC, Akif Tezcan F, Haynes CA, Walton MY, Andrade S, Einsle O, Howard JB. Structural basis of biological nitrogen fixation. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 363: 971-84; discussion 1. PMID 15901546 DOI: 10.1098/Rsta.2004.1539  1
2005 Corbett MC, Tezcan FA, Einsle O, Walton MY, Rees DC, Latimer MJ, Hedman B, Hodgson KO. Mo K- and L-edge X-ray absorption spectroscopic study of the ADP.AlF4--stabilized nitrogenase complex: comparison with MoFe protein in solution and single crystal. Journal of Synchrotron Radiation. 12: 28-34. PMID 15616362 DOI: 10.1107/S0909049504027827  1
2004 Escuredo E, Marinaki AM, Duley JA, Thein SL, Rees DC. The genetic basis of the interaction between pyrimidine 5′ nucleotidase I deficiency and hemoglobin E Nucleosides, Nucleotides and Nucleic Acids. 23: 1261-1263. PMID 15571242 DOI: 10.1081/NCN-200027532  1
2004 Ahmad HN, Ball C, Height SE, Rees DC. Rituximab in chronic, recurrent HIV-associated immune thrombocytopenic purpura [1] British Journal of Haematology. 127: 607-608. PMID 15566366 DOI: 10.1111/j.1365-2141.2004.05243.x  1
2004 Becker CF, Strop P, Bass RB, Hansen KC, Locher KP, Ren G, Yeager M, Rees DC, Kochendoerfer GG. Conversion of a mechanosensitive channel protein from a membrane-embedded to a water-soluble form by covalent modification with amphiphiles. Journal of Molecular Biology. 343: 747-58. PMID 15465059 DOI: 10.1016/J.Jmb.2004.08.062  1
2004 Nikolic-Hughes I, Rees DC, Herschlag D. Do electrostatic interactions with positively charged active site groups tighten the transition state for enzymatic phosphoryl transfer? Journal of the American Chemical Society. 126: 11814-9. PMID 15382915 DOI: 10.1021/Ja0480421  1
2004 Rees DC, Portmann B, Ball C, Mieli-Vergani G, Nicolaou A, Chetty MC, Stewart GW. Dehydrated hereditary stomatocytosis is associated with neonatal hepatitis British Journal of Haematology. 126: 272-276. PMID 15238150 DOI: 10.1111/j.1365-2141.2004.05037.x  1
2004 van Veen JJ, Reilly JT, Richards SJ, Whitby L, Goodfellow K, Granger V, Rees DC, Barnett D. Diagnosis of plasma cell leukaemia: findings of the UK NEQAS for Leucocyte Immunophenotyping scheme. Clinical and Laboratory Haematology. 26: 37-42. PMID 14738436 DOI: 10.1111/j.0141-9854.2003.00584.x  1
2004 Ambroggio XI, Rees DC, Deshaies RJ. JAMM: a metalloprotease-like zinc site in the proteasome and signalosome. Plos Biology. 2: E2. PMID 14737182 DOI: 10.1371/Journal.Pbio.0020002  1
2004 Rees DC. Preface by Douglas C. Rees Annual Review of Biophysics and Biomolecular Structure. 33. DOI: 10.1146/Annurev.Bb.33.051304.100011  0.01
2003 Bass RB, Locher KP, Borths E, Poon Y, Strop P, Lee A, Rees DC. The structures of BtuCD and MscS and their implications for transporter and channel function. Febs Letters. 555: 111-5. PMID 14630329 DOI: 10.1016/S0014-5793(03)01126-8  1
2003 Best S, Salvati F, Kallo J, Garner C, Height S, Thein SL, Rees DC. Lamin B-receptor mutations in Pelger-Huët anomaly British Journal of Haematology. 123: 542-544. PMID 14617022 DOI: 10.1046/j.1365-2141.2003.04621.x  1
2003 Perozo E, Rees DC. Structure and mechanism in prokaryotic mechanosensitive channels. Current Opinion in Structural Biology. 13: 432-42. PMID 12948773 DOI: 10.1016/S0959-440X(03)00106-4  1
2003 Locher KP, Bass RB, Rees DC. Structural biology. Breaching the barrier. Science (New York, N.Y.). 301: 603-4. PMID 12893929 DOI: 10.1126/Science.1088621  1
2003 Rees DC, Howard JB. The interface between the biological and inorganic worlds: iron-sulfur metalloclusters. Science (New York, N.Y.). 300: 929-31. PMID 12738849 DOI: 10.1126/Science.1083075  1
2003 Rees DC, Haddad FS. Bone transplantation Hospital Medicine. 64: 205-209. PMID 12731131  1
2003 Shapovalov G, Bass R, Rees DC, Lester HA. Open-state disulfide crosslinking between Mycobacterium tuberculosis mechanosensitive channel subunits. Biophysical Journal. 84: 2357-65. PMID 12668444 DOI: 10.1016/S0006-3495(03)75041-3  1
2003 Strop P, Bass R, Rees DC. Prokaryotic mechanosensitive channels. Advances in Protein Chemistry. 63: 177-209. PMID 12629971 DOI: 10.1016/S0065-3233(03)63008-1  1
2003 Rees DC. Advances in protein chemistry. Preface. Advances in Protein Chemistry. 63: xi-xvi. PMID 12629963 DOI: 10.1016/S0065-3233(03)63000-7  1
2003 Rees DC, Olujohungbe AD, Parker NE, Stephens AD, Telfer P, Wright J. Guidelines for the management of the acute painful crisis in sickle cell disease British Journal of Haematology. 120: 744-752. PMID 12614204 DOI: 10.1046/j.1365-2141.2003.04193.x  1
2003 Rees DC, Duley JA, Marinaki AM. Pyrimidine 5′ nucleotidase deficiency British Journal of Haematology. 120: 375-383. PMID 12580951 DOI: 10.1046/j.1365-2141.2003.03980.x  1
2003 Rees DC. Membrane proteins: Preface Advances in Protein Chemistry. 63: xi-xvi. DOI: 10.1016/S0065-3233(03)63000-7  1
2003 Rees DC, Rubin KI. Managing & protecting infrastructure assets Engineering Technology Management. 187-193.  1
2002 Schmid B, Einsle O, Chiu HJ, Willing A, Yoshida M, Howard JB, Rees DC. Biochemical and structural characterization of the cross-linked complex of nitrogenase: comparison to the ADP-AlF4(-)-stabilized structure. Biochemistry. 41: 15557-65. PMID 12501184 DOI: 10.1021/Bi026642B  1
2002 Bom A, Bradley M, Cameron K, Clark JK, Van Egmond J, Feilden H, MacLean EJ, Muir AW, Palin R, Rees DC, Zhang MQ. A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host. Angewandte Chemie (International Ed. in English). 41: 266-70. PMID 12491405 DOI: 10.1002/1521-3773(20020118)41:2<265::AID-ANIE265>3.0.CO;2-Q  1
2002 Borths EL, Locher KP, Lee AT, Rees DC. The structure of Escherichia coli BtuF and binding to its cognate ATP binding cassette transporter. Proceedings of the National Academy of Sciences of the United States of America. 99: 16642-7. PMID 12475936 DOI: 10.1073/Pnas.262659699  1
2002 Bass RB, Strop P, Barclay M, Rees DC. Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel. Science (New York, N.Y.). 298: 1582-7. PMID 12446901 DOI: 10.1126/Science.1077945  1
2002 Sumi S, Marinaki AM, Arenas M, Fairbanks L, Shobowale-Bakre M, Rees DC, Thein SL, Ansari A, Sanderson J, De Abreu RA, Simmonds HA, Duley JA. Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency Human Genetics. 111: 360-367. PMID 12384777 DOI: 10.1007/s00439-002-0798-z  1
2002 Einsle O, Tezcan FA, Andrade SL, Schmid B, Yoshida M, Howard JB, Rees DC. Nitrogenase MoFe-protein at 1.16 A resolution: a central ligand in the FeMo-cofactor. Science (New York, N.Y.). 297: 1696-700. PMID 12215645 DOI: 10.1126/Science.1073877  1
2002 Yeh AP, Ambroggio XI, Andrade SL, Einsle O, Chatelet C, Meyer J, Rees DC. High resolution crystal structures of the wild type and Cys-55-->Ser and Cys-59-->Ser variants of the thioredoxin-like [2Fe-2S] ferredoxin from Aquifex aeolicus. The Journal of Biological Chemistry. 277: 34499-507. PMID 12089152 DOI: 10.1074/Jbc.M205096200  1
2002 Axelrod HL, Abresch EC, Okamura MY, Yeh AP, Rees DC, Feher G. X-ray structure determination of the cytochrome c2: reaction center electron transfer complex from Rhodobacter sphaeroides. Journal of Molecular Biology. 319: 501-15. PMID 12051924 DOI: 10.1016/S0022-2836(02)00168-7  1
2002 Rees DC. Great metalloclusters in enzymology. Annual Review of Biochemistry. 71: 221-46. PMID 12045096 DOI: 10.1146/Annurev.Biochem.71.110601.135406  1
2002 Locher KP, Lee AT, Rees DC. The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism. Science (New York, N.Y.). 296: 1091-8. PMID 12004122 DOI: 10.1126/Science.1071142  1
2002 Spencer RH, Rees DC. The alpha-helix and the organization and gating of channels. Annual Review of Biophysics and Biomolecular Structure. 31: 207-33. PMID 11988468 DOI: 10.1146/Annurev.Biophys.31.082901.134329  1
2002 Adam JM, Bennett DJ, Bom A, Clark JK, Feilden H, Hutchinson EJ, Palin R, Prosser A, Rees DC, Rosair GM, Stevenson D, Tarver GJ, Zhang MQ. Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: synthesis and structure-activity relationships. Journal of Medicinal Chemistry. 45: 1806-16. PMID 11960492 DOI: 10.1021/jm011107f  1
2002 Schmid B, Ribbe MW, Einsle O, Yoshida M, Thomas LM, Dean DR, Rees DC, Burgess BK. Structure of a cofactor-deficient nitrogenase MoFe protein. Science (New York, N.Y.). 296: 352-6. PMID 11951047 DOI: 10.1126/Science.1070010  1
2002 Cameron KS, Fielding L, Mason R, Muir AW, Rees DC, Thorn S, Zhang MQ. Anionic cyclophanes as potential reversal agents of muscle relaxants by chemical chelation Bioorganic and Medicinal Chemistry Letters. 12: 753-755. PMID 11858995 DOI: 10.1016/S0960-894X(02)00017-3  1
2002 Iverson TM, Luna-Chavez C, Croal LR, Cecchini G, Rees DC. Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site. The Journal of Biological Chemistry. 277: 16124-30. PMID 11850430 DOI: 10.1074/Jbc.M200815200  1
2002 Rees DC, Juday GP. Plant species diversity on logged versus burned sites in central Alaska Forest Ecology and Management. 155: 291-302. DOI: 10.1016/S0378-1127(01)00566-7  1
2002 Rees DC. Metalloproteins to Membrane Proteins: Biological Energy Transduction Mechanisms Acs Symposium Series. 827: 202-215.  1
2001 Potter CG, Liu YT, Rees DC. Factor V Leiden mutation screened by PCR and detected with lanthanide-labeled probes Genetic Testing. 5: 291-297. PMID 11960573 DOI: 10.1089/109065701753617417  1
2001 Chiu HJ, Johnson E, Schröder I, Rees DC. Crystal structures of a novel ferric reductase from the hyperthermophilic archaeon Archaeoglobus fulgidus and its complex with NADP+ Structure. 9: 311-319. PMID 11525168 DOI: 10.1016/S0969-2126(01)00589-5  1
2001 Rees DC. Crystallographic analyses of hyperthermophilic proteins Methods in Enzymology. 334: 423-437. PMID 11398481 DOI: 10.1016/S0076-6879(01)34484-1  1
2001 Iverson TM, Arciero DM, Hooper AB, Rees DC. High-resolution structures of the oxidized and reduced states of cytochrome c554 from Nitrosomonas europaea. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 6: 390-7. PMID 11372197 DOI: 10.1007/S007750100213  1
2001 Rees DC, Robertson AD. Some thermodynamic implications for the thermostability of proteins Protein Science. 10: 1187-1194. PMID 11369857 DOI: 10.1110/Ps.180101  1
2001 Locher KP, Hans M, Yeh AP, Schmid B, Buckel W, Rees DC. Crystal structure of the Acidaminococcus fermentans 2-hydroxyglutaryl-CoA dehydratase component A Journal of Molecular Biology. 307: 297-308. PMID 11243821 DOI: 10.1006/Jmbi.2000.4496  1
2001 Strop P, Takahara PM, Chiu HJ, Angove HC, Burgess BK, Rees DC. Crystal structure of the all-ferrous [4Fe-4S]0 form of the nitrogenase iron protein from Azotobacter vinelandii Biochemistry. 40: 651-656. PMID 11170381 DOI: 10.1021/Bi0016467  1
2001 Chiu H, Peters JW, Lanzilotta WN, Ryle MJ, Seefeldt LC, Howard JB, Rees DC. MgATP-Bound and nucleotide-free structures of a nitrogenase protein complex between the Leu 127 Delta-Fe-protein and the MoFe-protein. Biochemistry. 40: 641-50. PMID 11170380 DOI: 10.1021/Bi001645E  1
2001 Strop P, Smith KS, Iverson TM, Ferry JG, Rees DC. Crystal structure of the "cab"-type beta class carbonic anhydrase from the archaeon Methanobacterium thermoautotrophicum. The Journal of Biological Chemistry. 276: 10299-305. PMID 11096105 DOI: 10.1074/Jbc.M009182200  1
2000 Rees DC, Howard JB. Nitrogenase: standing at the crossroads. Current Opinion in Chemical Biology. 4: 559-66. PMID 11006545 DOI: 10.1016/S1367-5931(00)00132-0  1
2000 Iverson TM, Luna-Chavez C, Schröder I, Cecchini G, Rees DC. Analyzing your complexes: structure of the quinol-fumarate reductase respiratory complex. Current Opinion in Structural Biology. 10: 448-55. PMID 10981634 DOI: 10.1016/S0959-440X(00)00113-5  1
2000 Iverson TM, Alber BE, Kisker C, Ferry JG, Rees DC. A closer look at the active site of gamma-class carbonic anhydrases: high-resolution crystallographic studies of the carbonic anhydrase from Methanosarcina thermophila. Biochemistry. 39: 9222-31. PMID 10924115 DOI: 10.1021/Bi000204S  1
2000 Yeh AP, Chatelet C, Soltis SM, Kuhn P, Meyer J, Rees DC. Structure of a thioredoxin-like [2Fe-2S] ferredoxin from Aquifex aeolicus Journal of Molecular Biology. 300: 587-595. PMID 10884354 DOI: 10.1006/Jmbi.2000.3871  1
2000 Luna-Chavez C, Iverson TM, Rees DC, Cecchini G. Overexpression, purification, and crystallization of the membrane-bound fumarate reductase from Escherichia coli. Protein Expression and Purification. 19: 188-96. PMID 10833406 DOI: 10.1006/Prep.2000.1238  1
2000 Yeh AP, Hu Y, Jenney FE, Adams MWW, Rees DC. Structures of the superoxide reductase from Pyrococcus furiosus in the oxidized and reduced states Biochemistry. 39: 2499-2508. PMID 10704199 DOI: 10.1021/Bi992428K  1
2000 Kielkopf CL, Ding S, Kuhn P, Rees DC. Conformational flexibility of B-DNA at 0.74 A resolution: d(CCAGTACTGG)(2). Journal of Molecular Biology. 296: 787-801. PMID 10677281 DOI: 10.1006/Jmbi.1999.3478  1
2000 Rees DC, Eisenberg D. Turning a reference inside-out: Commentary on an article by Stevens and Arkin entitled: 'Are membrane proteins 'inside-out' proteins?' (Proteins 1999;36:135-143) Proteins: Structure, Function and Genetics. 38: 121-122. PMID 10656259 DOI: 10.1002/(Sici)1097-0134(20000201)38:2<121::Aid-Prot1>3.0.Co;2-M  1
2000 Kielkopf CL, Erkkila KE, Hudson BP, Barton JK, Rees DC. Structure of a photoactive rhodium complex intercalated into DNA. Nature Structural Biology. 7: 117-21. PMID 10655613 DOI: 10.1038/72385  1
2000 Rees DC, Chang G, Spencer RH. Crystallographic analyses of ion channels: Lessons and challenges Journal of Biological Chemistry. 275: 713-716. PMID 10625597 DOI: 10.1074/Jbc.275.2.713  1
2000 Kielkopf CL, Bremer RE, White S, Szewczyk JW, Turner JM, Baird EE, Dervan PB, Rees DC. Structural effects of DNA sequence on T.A recognition by hydroxypyrrole/pyrrole pairs in the minor groove. Journal of Molecular Biology. 295: 557-67. PMID 10623546 DOI: 10.1006/Jmbi.1999.3364  1
1999 Rees DC, Howard JB. Structural bioenergetics and energy transduction mechanisms. Journal of Molecular Biology. 293: 343-50. PMID 10550213 DOI: 10.1006/Jmbi.1999.3005  1
1999 Iverson TM, Luna-Chavez C, Cecchini G, Rees DC. Structure of the Escherichia coli fumarate reductase respiratory complex. Science (New York, N.Y.). 284: 1961-6. PMID 10373108 DOI: 10.1126/Science.284.5422.1961  1
1999 Grossmann JG, Hasnain SS, Yousafzai FK, Smith BE, Eady RR, Schindelin H, Kisker C, Howard JB, Tsuruta H, Muller J, Rees DC. Comparing crystallographic and solution structures of nitrogenase complexes Acta Crystallographica Section D: Biological Crystallography. 55: 727-728. PMID 10336305 DOI: 10.1107/S0907444999003856  1
1999 Faham S, Day MW, Connick WB, Crane BR, Di Bilio AJ, Schaefer WP, Rees DC, Gray HB. Structures of ruthenium-modified Pseudomonas aeruginosa azurin and [Ru(2,2'-bipyridine)2(imidazole)2]SO4 x 10H2O. Acta Crystallographica. Section D, Biological Crystallography. 55: 379-85. PMID 10089343 DOI: 10.1107/S0907444998010464  1
1999 Hu Y, Faham S, Roy R, Adams MWW, Rees DC. Formaldehyde ferredoxin oxidoreductase from Pyrococcus furiosus: The 1.85 Å resolution crystal structure and its mechanistic implications Journal of Molecular Biology. 286: 899-914. PMID 10024458 DOI: 10.1006/Jmbi.1998.2488  1
1999 Faham S, Linhardt RJ, Rees DC. Diversity does make a difference: fibroblast growth factor-heparin interactions. Current Opinion in Structural Biology. 8: 578-86. PMID 9818261 DOI: 10.1016/S0959-440X(98)80147-4  0.52
1998 Iverson TM, Arciero DM, Hsu BT, Logan MS, Hooper AB, Rees DC. Heme packing motifs revealed by the crystal structure of the tetra-heme cytochrome c554 from Nitrosomonas europaea. Nature Structural Biology. 5: 1005-12. PMID 9808046 DOI: 10.1038/2975  1
1998 Kielkopf CL, White S, Szewczyk JW, Turner JM, Baird EE, Dervan PB, Rees DC. A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA. Science (New York, N.Y.). 282: 111-5. PMID 9756473 DOI: 10.1126/Science.282.5386.111  1
1998 Schlessman JL, Woo D, Joshua-Tor L, Howard JB, Rees DC. Conformational variability in structures of the nitrogenase iron proteins from Azotobacter vinelandii and Clostridium pasteurianum. Journal of Molecular Biology. 280: 669-85. PMID 9677296 DOI: 10.1006/Jmbi.1998.1898  1
1998 Kielkopf CL, Baird EE, Dervan PB, Rees DC. Structural basis for G.C recognition in the DNA minor groove. Nature Structural Biology. 5: 104-9. PMID 9461074 DOI: 10.1038/Nsb0298-104  1
1998 Abresch EG, Paddock ML, Stowell MHB, McPhillips TM, Axelrod HL, Soltis SM, Rees DC, Okamura MY, Feher G. Identification of proton transfer pathways in the x-ray crystal structure of the bacterial reaction center from Rhodobacter sphaeroides Photosynthesis Research. 55: 119-125. DOI: 10.1023/A:1006047519260  1
1998 Bau R, Rees DC, Kurtz DM, Scott RA, Huang H, Adams MWW, Eidsness MK. Crystal structure of rubredoxin from Pyrococcus furiosus at 0.95 Å resolution, and the structures of N-terminal methionine and formylmethionine variants of Pf Rd. Contributions of N-terminal interactions to thermostability Journal of Biological Inorganic Chemistry. 3: 484-493. DOI: 10.1007/S007750050258  1
1997 Kisker C, Schindelin H, Pacheco A, Wehbi WA, Garrett RM, Rajagopalan KV, Enemark JH, Rees DC. Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase. Cell. 91: 973-83. PMID 9428520 DOI: 10.1016/S0092-8674(00)80488-2  1
1997 Kisker C, Schindelin H, Rees DC. Molybdenum-cofactor-containing enzymes: Structure and mechanism Annual Review of Biochemistry. 66: 233-267. PMID 9242907 DOI: 10.1146/Annurev.Biochem.66.1.233  1
1997 Schindelin H, Kisker C, Schlessman JL, Howard JB, Rees DC. Structure of ADP x AIF4(-)-stabilized nitrogenase complex and its implications for signal transduction. Nature. 387: 370-6. PMID 9163420 DOI: 10.1038/387370A0  1
1997 Stowell MH, McPhillips TM, Rees DC, Soltis SM, Abresch E, Feher G. Light-induced structural changes in photosynthetic reaction center: implications for mechanism of electron-proton transfer. Science (New York, N.Y.). 276: 812-6. PMID 9115209 DOI: 10.1126/Science.276.5313.812  1
1997 Peters JW, Stowell MH, Soltis SM, Finnegan MG, Johnson MK, Rees DC. Redox-dependent structural changes in the nitrogenase P-cluster. Biochemistry. 36: 1181-7. PMID 9063865 DOI: 10.1021/Bi9626665  1
1997 Rees DC, Hu Y, Kisker C, Schindelin H. A crystallographic view of the molybdenum cofactor Journal of the Chemical Society - Dalton Transactions. 3909-3914. DOI: 10.1039/A704048B  1
1997 Magnuson JK, Paustian TD, Shah VK, Dean DR, Roberts GP, Rees DC, Howard JB. Nitrogenase iron-molybdenum cofactor binding site: Protein conformational changes associated with cofactor binding Tetrahedron. 53: 11971-11984. DOI: 10.1016/S0040-4020(97)00710-2  1
1997 Schindelin H, Kisker C, Rees DC. The molybdenum-cofactor: A crystallographic perspective Journal of Biological Inorganic Chemistry. 2: 773-781. DOI: 10.1007/S007750050194  1
1997 Faham S, Mizoguchi TJ, Adman ET, Gray HB, Richards JH, Rees DC. Role of the active-site cysteine of Pseudomonas aeruginosa azurin. Crystal structure analysis of the Cu(II)(Cys112Asp) protein Journal of Biological Inorganic Chemistry. 2: 464-469. DOI: 10.1007/S007750050157  1
1996 Howard JB, Rees DC. Structural Basis of Biological Nitrogen Fixation. Chemical Reviews. 96: 2965-2982. PMID 11848848 DOI: 10.1021/Cr9500545  1
1996 Johnson MK, Rees DC, Adams MW. Tungstoenzymes. Chemical Reviews. 96: 2817-2840. PMID 11848842  1
1996 Peters JW, Stowell MH, Rees DC. A leucine-rich repeat variant with a novel repetitive protein structural motif. Nature Structural Biology. 3: 991-4. PMID 8946850 DOI: 10.1038/Nsb1296-991  1
1996 McPhillips TM, Hsu BT, Sherman MA, Mas MT, Rees DC. Structure of the R65Q mutant of yeast 3-phosphoglycerate kinase complexed with Mg-AMP-PNP and 3-phospho-D-glycerate Biochemistry. 35: 4118-4127. PMID 8672447 DOI: 10.1021/Bi952500O  1
1996 Kisker C, Schindelin H, Alber BE, Ferry JG, Rees DC. A left-handed β-helix revealed by the crystal structure of a carbonic anhydrase from the archaeon Methanosarcina thermophila Embo Journal. 15: 2323-2330. PMID 8665839  1
1996 Schindelin H, Kisker C, Hilton J, Rajagopalan KV, Rees DC. Crystal structure of DMSO reductase: redox-linked changes in molybdopterin coordination. Science (New York, N.Y.). 272: 1615-21. PMID 8658134 DOI: 10.1126/Science.272.5268.1615  1
1996 Faham S, Hileman RE, Fromm JR, Linhardt RJ, Rees DC. Heparin structure and interactions with basic fibroblast growth factor. Science (New York, N.Y.). 271: 1116-20. PMID 8599088 DOI: 10.1126/Science.271.5252.1116  0.32
1996 Stowell MHB, Soltis SM, Kisker C, Peters JW, Schindelin H, Rees DC, Cascio D, Beamer L, Hart PJ, Wiener MC, Whitby FG. A simple device for studying macromolecular crystals under moderate gas pressures (0.1-10 MPa) Journal of Applied Crystallography. 29: 608-613. DOI: 10.1107/S0021889896004712  1
1996 Stowell MHB, Rock RS, Rees DC, Chan SI. Efficient synthesis of photolabile alkoxy benzoin protecting groups Tetrahedron Letters. 37: 307-310. DOI: 10.1016/0040-4039(95)02159-0  1
1996 Kisker C, Schindelin H, Alber BE, Ferry JG, Rees DC. A left-hand beta-helix revealed by the crystal structure of a carbonic anhydrase from the archaeon Methanosarcina thermophila. The Embo Journal. 15: 2323-2330. DOI: 10.1002/J.1460-2075.1996.Tb00588.X  1
1995 Arakawa T, Holst P, Narhi LO, Philo JS, Wen J, Prestrelski SJ, Zhu X, Rees DC, Fox GM. The importance of Arg40 and 45 in the mitogenic activity and structural stability of basic fibroblast growth factor: effects of acidic amino acid substitutions. Journal of Protein Chemistry. 14: 263-74. PMID 8590594 DOI: 10.1007/Bf01886783  1
1995 Chan MK, Mukund S, Kletzin A, Adams MW, Rees DC. Structure of a hyperthermophilic tungstopterin enzyme, aldehyde ferredoxin oxidoreductase. Science (New York, N.Y.). 267: 1463-9. PMID 7878465 DOI: 10.1126/Science.7878465  1
1995 Stowell MH, Rees DC. Structure and stability of membrane proteins. Advances in Protein Chemistry. 46: 279-311. PMID 7771322 DOI: 10.1016/S0065-3233(08)60338-1  1
1995 Kletzin A, Mukund S, Kelley-Crouse TL, Chan MK, Rees DC, Adams MW. Molecular characterization of the genes encoding the tungsten-containing aldehyde ferredoxin oxidoreductase from Pyrococcus furiosus and formaldehyde ferredoxin oxidoreductase from Thermococcus litoralis. Journal of Bacteriology. 177: 4817-9. PMID 7642512 DOI: 10.1128/Jb.177.16.4817-4819.1995  1
1995 Joshua-Tor L, Xu HE, Johnston SA, Rees DC. Crystal structure of a conserved protease that binds DNA: The bleomycin hydrolase, Gal6 Science. 269: 945-950. PMID 7638617 DOI: 10.1126/Science.7638617  1
1994 Axelrod HL, Feher G, Allen JP, Chirino AJ, Day MW, Hsu BT, Rees DC. Crystallization and X-ray structure determination of cytochrome c2 from Rhodobacter sphaeroides in three crystal forms. Acta Crystallographica. Section D, Biological Crystallography. 50: 596-602. PMID 15299423 DOI: 10.1107/S0907444994001319  1
1994 Chirino AJ, Lous EJ, Huber M, Allen JP, Schenck CC, Paddock ML, Feher G, Rees DC. Crystallographic analyses of site-directed mutants of the photosynthetic reaction center from Rhodobacter sphaeroides. Biochemistry. 33: 4584-93. PMID 8161514 DOI: 10.1021/Bi00181A020  1
1994 Howard JB, Rees DC. Nitrogenase: a nucleotide-dependent molecular switch. Annual Review of Biochemistry. 63: 235-64. PMID 7979238 DOI: 10.1146/Annurev.Bi.63.070194.001315  1
1993 Chan MK, Kim J, Rees DC. The nitrogenase FeMo-Cofactor and P-Cluster pair: 2.2 Å resolution structures Science. 260. PMID 8484118 DOI: 10.1126/Science.8484118  1
1993 Kim KH, Kwon BM, Myers AG, Rees DC. Crystal structure of neocarzinostatin, an antitumor protein-chromophore complex. Science (New York, N.Y.). 262: 1042-6. PMID 8235619 DOI: 10.1126/Science.8235619  0.36
1993 Arakawa T, Horan TP, Narhi LO, Rees DC, Schiffer SG, Holst PL, Prestrelski SJ, Tsai LB, Fox GM. Production and characterization of an analog of acidic fibroblast growth factor with enhanced stability and biological activity. Protein Engineering. 6: 541-6. PMID 7692436 DOI: 10.1093/Protein/6.5.541  1
1993 Rees DC, Chan MK, Kim J. Structure and Function of Nitrogenase Advances in Inorganic Chemistry. 40. DOI: 10.1016/S0898-8838(08)60182-8  1
1992 Kim J, Rees DC. Crystallographic structure and functional implications of the nitrogenase molybdenum-iron protein from azotobacter vinelandii. Nature. 360: 553-560. PMID 25989647 DOI: 10.1038/360553A0  1
1992 Cramer WA, Engelman DM, Von Heijne G, Rees DC. Forces involved in the assembly and stabilization of membrane proteins Faseb Journal. 6: 3397-3402. PMID 1464373 DOI: 10.1096/Fasebj.6.15.1464373  1
1992 Blake PR, Day MW, Hsu BT, Joshua-Tor L, Park JB, Hare DR, Adams MW, Rees DC, Summers MF. Comparison of the X-ray structure of native rubredoxin from Pyrococcus furiosus with the NMR structure of the zinc-substituted protein. Protein Science : a Publication of the Protein Society. 1: 1522-5. PMID 1303770 DOI: 10.1002/Pro.5560011113  1
1992 Day MW, Hsu BT, Joshua-Tor L, Park JB, Zhou ZH, Adams MWW, Rees DC. X-ray crystal structures of the oxidized and reduced forms of the rubredoxin from the marine hyperthermophilic archaebacterium Pyrococcus furiosus Protein Science. 1: 1494-1507. PMID 1303768 DOI: 10.1002/Pro.5560011111  1
1991 Howard JB, Rees DC. Perspectives on non-heme iron protein chemistry. Advances in Protein Chemistry. 42: 199-280. PMID 1793006 DOI: 10.1016/S0065-3233(08)60537-9  1
1991 Zhu X, Komiya H, Chirino A, Faham S, Fox GM, Arakawa T, Hsu BT, Rees DC. Three-dimensional structures of acidic and basic fibroblast growth factors. Science (New York, N.Y.). 251: 90-3. PMID 1702556 DOI: 10.1126/Science.1702556  1
1991 Krantzman KD, Rees DC, Farrelly D. Computational study of the imaging of a molecular crystal with the atomic force microscope Journal of Physical Chemistry. 95: 9039-9042. DOI: 10.1021/J100176A006  1
1990 Francis EZ, Kimmel CA, Rees DC. Workshop on the qualitative and quantitative comparability of human and animal developmental neurotoxicity: summary and implications. Neurotoxicology and Teratology. 12: 285-92. PMID 2196427 DOI: 10.1016/0892-0362(90)90101-H  0.01
1990 Rees DC, Francis EZ, Kimmel CA. Scientific and regulatory issues relevant to assessing risk for developmental neurotoxicity: an overview. Neurotoxicology and Teratology. 12: 175-81. PMID 2196418 DOI: 10.1016/0892-0362(90)90089-U  0.01
1990 Rees DC, Farrelly D. 2 Biological Electron Transfer Enzymes. 19: 37-97. DOI: 10.1016/S1874-6047(08)60195-X  1
1989 Willing AH, Georgiadis MM, Rees DC, Howard JB. Cross-linking of nitrogenase components. Structure and activity of the covalent complex. The Journal of Biological Chemistry. 264: 8499-503. PMID 2722786  1
1989 Rees DC, Komiya H, Yeates TO, Allen JP, Feher G. The bacterial photosynthetic reaction center as a model for membrane proteins. Annual Review of Biochemistry. 58: 607-33. PMID 2673018 DOI: 10.1146/Annurev.Bi.58.070189.003135  1
1989 Feher G, Allen JP, Okamura MY, Rees DC. Structure and function of bacterial photosynthetic reaction centres Nature. 339: 111-116. DOI: 10.1038/339111A0  1
1988 Yeates TO, Komiya H, Chirino A, Rees DC, Allen JP, Feher G. Structure of the reaction center from Rhodobacter sphaeroides R-26 and 2.4.1: protein-cofactor (bacteriochlorophyll, bacteriopheophytin, and carotenoid) interactions. Proceedings of the National Academy of Sciences of the United States of America. 85: 7993-7. PMID 3186702 DOI: 10.1073/Pnas.85.21.7993  1
1988 Komiya H, Yeates TO, Rees DC, Allen JP, Feher G. Structure of the reaction center from Rhodobacter sphaeroides R-26 and 2.4.1: symmetry relations and sequence comparisons between different species. Proceedings of the National Academy of Sciences of the United States of America. 85: 9012-6. PMID 3057498 DOI: 10.1073/Pnas.85.23.9012  1
1988 Allen JP, Feher G, Yeates TO, Komiya H, Rees DC. Structure of the reaction center from Rhodobacter sphaeroides R-26: protein-cofactor (quinones and Fe2+) interactions. Proceedings of the National Academy of Sciences of the United States of America. 85: 8487-91. PMID 3054889 DOI: 10.1073/Pnas.85.22.8487  1
1987 Yeates TO, Komiya H, Rees DC, Allen JP, Feher G. Structure of the reaction center from Rhodobacter sphaeroides R-26: membrane-protein interactions. Proceedings of the National Academy of Sciences of the United States of America. 84: 6438-42. PMID 3306679 DOI: 10.1073/Pnas.84.18.6438  1
1987 Allen JP, Feher G, Yeates TO, Komiya H, Rees DC. Structure of the reaction center from Rhodobacter sphaeroides R-26: the cofactors. Proceedings of the National Academy of Sciences of the United States of America. 84: 5730-4. PMID 3303032 DOI: 10.1073/Pnas.84.16.5730  1
1987 Allen JP, Feher G, Yeates TO, Komiya H, Rees DC. Structure of the reaction center from Rhodobacter sphaeroides R-26: the protein subunits. Proceedings of the National Academy of Sciences of the United States of America. 84: 6162-6. PMID 2819866 DOI: 10.1073/Pnas.84.17.6162  1
1987 Knossow M, Lewis M, Rees D, Wilson IA, Skehel JJ, Wiley DC. The refinement of the haemagglutinin membrane glycoprotein of influenza virus. Addendum Acta Crystallographica Section B. 43: 302-302. DOI: 10.1107/S0108768187097854  1
1986 Allen JP, Feher G, Yeates TO, Rees DC, Deisenhofer J, Michel H, Huber R. Structural homology of reaction centers from Rhodopseudomonas sphaeroides and Rhodopseudomonas viridis as determined by x-ray diffraction. Proceedings of the National Academy of Sciences of the United States of America. 83: 8589-93. PMID 3022298 DOI: 10.1073/Pnas.83.22.8589  1
1985 Lewis M, Rees DC. Fractal surfaces of proteins. Science (New York, N.Y.). 230: 1163-5. PMID 4071040 DOI: 10.1126/Science.4071040  0.4
1984 Shoham G, Rees DC, Lipscomb WN. Effects of pH on the structure and function of carboxypeptidase A: crystallographic studies. Proceedings of the National Academy of Sciences of the United States of America. 81: 7767-71. PMID 6595659 DOI: 10.1073/Pnas.81.24.7767  1
1984 Shoham G, Rees DC, Lipscomb WN, Zanotti G, Wieland T. Crystal and molecular structure of S-deoxo[Ile3]amaninamide: A synthetic analogue of Amanita toxins Journal of the American Chemical Society. 106: 4606-4615. DOI: 10.1021/Ja00328A051  1
1983 Rees DC, Lewis M, Lipscomb WN. Refined crystal structure of carboxypeptidase A at 1.54 A resolution. Journal of Molecular Biology. 168: 367-87. PMID 6887246 DOI: 10.1016/S0022-2836(83)80024-2  1
1983 Rees DC, Lipscomb WN. Crystallographic studies on apocarboxypeptidase A and the complex with glycyl-L-tyrosine. Proceedings of the National Academy of Sciences of the United States of America. 80: 7151-4. PMID 6580631 DOI: 10.1073/Pnas.80.23.7151  1
1983 Rees DC, Howard JB. Crystallization of the Azotobacter vinelandii nitrogenase iron protein. The Journal of Biological Chemistry. 258: 12733-4. PMID 6579051  1
1982 Rees DC, Lipscomb WN. Refined crystal structure of the potato inhibitor complex of carboxypeptidase A at 2.5 A resolution. Journal of Molecular Biology. 160: 475-98. PMID 7154070 DOI: 10.1016/0022-2836(82)90309-6  1
1981 Rees DC, Lipscomb WN. Binding of ligands to the active site of carboxypeptidase A. Proceedings of the National Academy of Sciences of the United States of America. 78: 5455-9. PMID 6946483 DOI: 10.1073/Pnas.78.9.5455  1
1981 Rees DC, Lewis M, Honzatko RB, Lipscomb WN, Hardman KD. Zinc environment and cis peptide bonds in carboxypeptidase A at 1.75-A resolution. Proceedings of the National Academy of Sciences of the United States of America. 78: 3408-12. PMID 6943549 DOI: 10.1073/Pnas.78.6.3408  1
1980 Rees DC, Lipscomb WN. Structure of the potato inhibitor complex of carboxypeptidase A at 2.5-A resolution. Proceedings of the National Academy of Sciences of the United States of America. 77: 4633-7. PMID 6933511 DOI: 10.1073/Pnas.77.8.4633  1
1980 Rees DC, Honzatko RB, Lipscomb WN. Structure of an actively exchanging complex between carboxypeptidase A and a substrate analogue. Proceedings of the National Academy of Sciences of the United States of America. 77: 3288-91. PMID 6932021 DOI: 10.1073/Pnas.77.6.3288  1
1980 Rees DC, Lipscomb WN. Structure of potato inhibitor complex of carboxypeptidase A at 5.5-A resolution. Proceedings of the National Academy of Sciences of the United States of America. 77: 277-80. PMID 6928619  1
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