Edward Alan Dennis - Publications

Affiliations: 
University of California, San Diego, La Jolla, CA 
Area:
Biochemistry: phospholipase A2, signal transduction in macrophages, lipid maps, prostaglandin regulation, mass spec of lipids and proteins
Website:
http://www-chem.ucsd.edu/faculty/profiles/dennis_edward_a.html

187 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Psarra A, Kokotou MG, Galiatsatou G, Mouchlis VD, Dennis EA, Kokotos G. Correction to "Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A (GIVA cPLA)". Acs Omega. 4: 10714. PMID 31460169 DOI: 10.1021/acsomega.9b01662  0.48
2019 Dedaki C, Kokotou MG, Mouchlis VD, Limnios D, Lei X, Mu CT, Ramanadham S, Magrioti V, Dennis EA, Kokotos G. β-Lactones: A Novel Class of Ca2+-Independent Phospholipase A2 (Group VIA iPLA2) Inhibitors with Ability to Inhibit β-Cell Apoptosis. Journal of Medicinal Chemistry. PMID 30798607 DOI: 10.1021/acs.jmedchem.8b01216  0.48
2018 Psarra A, Kokotou MG, Galiatsatou G, Mouchlis VD, Dennis EA, Kokotos G. Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A (GIVA cPLA). Acs Omega. 3: 8843-8853. PMID 30197994 DOI: 10.1021/acsomega.8b01214  0.48
2018 Gregus AM, Buczynski MW, Dumlao DS, Norris PC, Rai G, Simeonov A, Maloney DJ, Jadhav A, Xu Q, Wei SC, Fitzsimmons BL, Dennis EA, Yaksh TL. Inhibition of Spinal 15-LOX-1 Attenuates TLR4-Dependent, NSAID-Unresponsive Hyperalgesia in Male Rats. Pain. PMID 30130298 DOI: 10.1097/j.pain.0000000000001373  0.76
2018 Mouchlis VD, Chen Y, McCammon JA, Dennis EA. Membrane Allostery and Unique Hydrophobic Sites Promote Enzyme Substrate Specificity. Journal of the American Chemical Society. PMID 29342349 DOI: 10.1021/jacs.7b12045  0.48
2017 Kokotou MG, Galiatsatou G, Magrioti V, Koutoulogenis G, Barbayianni E, Limnios D, Mouchlis VD, Satpathy B, Navratil A, Dennis EA, Kokotos G. 2-Oxoesters: A Novel Class of Potent and Selective Inhibitors of Cytosolic Group IVA Phospholipase A2. Scientific Reports. 7: 7025. PMID 28765606 DOI: 10.1038/s41598-017-07330-5  0.48
2016 Smyrniotou A, Kokotou MG, Mouchlis VD, Barbayianni E, Kokotos G, Dennis EA, Constantinou-Kokotou V. 2-Oxoamides based on dipeptides as selective calcium-independent phospholipase A2 inhibitors. Bioorganic & Medicinal Chemistry. PMID 28034646 DOI: 10.1016/j.bmc.2016.12.007  0.56
2016 Antonopoulou G, Magrioti V, Kokotou MG, Nikolaou A, Barbayianni E, Mouchlis VD, Dennis EA, Kokotos G. 2-Oxoamide inhibitors of cytosolic group IVA phospholipase A2 with reduced lipophilicity. Bioorganic & Medicinal Chemistry. PMID 27522578 DOI: 10.1016/j.bmc.2016.07.057  0.48
2016 Mouchlis VD, Limnios D, Kokotou MG, Barbayianni E, Kokotos G, McCammon JA, Dennis EA. Development of Potent and Selective Inhibitors for Group VIA Calcium-Independent Phospholipase A2 Guided by Molecular Dynamics and Structure-Activity Relationships. Journal of Medicinal Chemistry. 59: 4403-14. PMID 27087127 DOI: 10.1021/acs.jmedchem.6b00377  0.48
2016 Gupta S, Kihara Y, Maurya MR, Norris PC, Dennis EA, Subramaniam S. Computational Modeling of Competitive Metabolism Between ω3- and ω6 Polyunsaturated Fatty Acids in Inflammatory Macrophages. The Journal of Physical Chemistry. B. PMID 27063350 DOI: 10.1021/acs.jpcb.6b02036  1
2015 Mouchlis VD, Dennis EA. Membrane and inhibitor interactions of intracellular phospholipases A2. Advances in Biological Regulation. PMID 26774606 DOI: 10.1016/j.jbior.2015.11.011  1
2015 Dennis EA, Norris PC. Eicosanoid storm in infection and inflammation. Nature Reviews. Immunology. PMID 26139350 DOI: 10.1038/nri3859  1
2015 Dennis EA. Introduction to Thematic Review Series: Phospholipases: Central Role in Lipid Signaling and Disease. Journal of Lipid Research. PMID 26031662 DOI: 10.1194/jlr.E061101  1
2015 Gorden DL, Myers DS, Ivanova PT, Fahy E, Maurya MR, Gupta S, Min J, Spann NJ, McDonald JG, Kelly SL, Duan J, Sullards MC, Leiker TJ, Barkley RM, Quehenberger O, ... ... Dennis EA, et al. Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. Journal of Lipid Research. 56: 722-36. PMID 25598080 DOI: 10.1194/jlr.P056002  1
2015 Astarita G, Kendall AC, Dennis EA, Nicolaou A. Targeted lipidomic strategies for oxygenated metabolites of polyunsaturated fatty acids. Biochimica Et Biophysica Acta. 1851: 456-468. PMID 25486530 DOI: 10.1016/j.bbalip.2014.11.012  1
2015 Loomba R, Quehenberger O, Armando A, Dennis EA. Polyunsaturated fatty acid metabolites as novel lipidomic biomarkers for noninvasive diagnosis of nonalcoholic steatohepatitis. Journal of Lipid Research. 56: 185-92. PMID 25404585 DOI: 10.1194/jlr.P055640  1
2014 Baker PR, Armando AM, Campbell JL, Quehenberger O, Dennis EA. Three-dimensional enhanced lipidomics analysis combining UPLC, differential ion mobility spectrometry, and mass spectrometric separation strategies. Journal of Lipid Research. 55: 2432-42. PMID 25225680 DOI: 10.1194/jlr.D051581  1
2014 Kokotos G, Feuerherm AJ, Barbayianni E, Shah I, Sæther M, Magrioti V, Nguyen T, Constantinou-Kokotou V, Dennis EA, Johansen B. Inhibition of group IVA cytosolic phospholipase A2 by thiazolyl ketones in vitro, ex vivo, and in vivo. Journal of Medicinal Chemistry. 57: 7523-35. PMID 25152071 DOI: 10.1021/jm500192s  1
2014 Norris PC, Gosselin D, Reichart D, Glass CK, Dennis EA. Phospholipase A2 regulates eicosanoid class switching during inflammasome activation. Proceedings of the National Academy of Sciences of the United States of America. 111: 12746-51. PMID 25139986 DOI: 10.1073/pnas.1404372111  1
2014 Wang Y, Armando AM, Quehenberger O, Yan C, Dennis EA. Comprehensive ultra-performance liquid chromatographic separation and mass spectrometric analysis of eicosanoid metabolites in human samples. Journal of Chromatography. A. 1359: 60-9. PMID 25074422 DOI: 10.1016/j.chroma.2014.07.006  1
2014 Jiao J, Ishikawa TO, Dumlao DS, Norris PC, Magyar CE, Mikulec C, Catapang A, Dennis EA, Fischer SM, Herschman HR. Targeted deletion and lipidomic analysis identify epithelial cell COX-2 as a major driver of chemically induced skin cancer. Molecular Cancer Research : McR. 12: 1677-88. PMID 25063587 DOI: 10.1158/1541-7786.MCR-14-0397-T  1
2014 Ravandi A, Leibundgut G, Hung MY, Patel M, Hutchins PM, Murphy RC, Prasad A, Mahmud E, Miller YI, Dennis EA, Witztum JL, Tsimikas S. Release and capture of bioactive oxidized phospholipids and oxidized cholesteryl esters during percutaneous coronary and peripheral arterial interventions in humans. Journal of the American College of Cardiology. 63: 1961-71. PMID 24613321 DOI: 10.1016/j.jacc.2014.01.055  1
2014 Kihara Y, Gupta S, Maurya MR, Armando A, Shah I, Quehenberger O, Glass CK, Dennis EA, Subramaniam S. Modeling of eicosanoid fluxes reveals functional coupling between cyclooxygenases and terminal synthases. Biophysical Journal. 106: 966-75. PMID 24559999 DOI: 10.1016/j.bpj.2014.01.015  1
2014 Jiao J, Mikulec C, Ishikawa TO, Magyar C, Dumlao DS, Dennis EA, Fischer SM, Herschman H. Cell-type-specific roles for COX-2 in UVB-induced skin cancer. Carcinogenesis. 35: 1310-9. PMID 24469308 DOI: 10.1093/carcin/bgu020  1
2014 Norris PC, Dennis EA. A lipidomic perspective on inflammatory macrophage eicosanoid signaling. Advances in Biological Regulation. 54: 99-110. PMID 24113376 DOI: 10.1016/j.jbior.2013.09.009  1
2013 Choi SH, Yin H, Ravandi A, Armando A, Dumlao D, Kim J, Almazan F, Taylor AM, McNamara CA, Tsimikas S, Dennis EA, Witztum JL, Miller YI. Polyoxygenated cholesterol ester hydroperoxide activates TLR4 and SYK dependent signaling in macrophages. Plos One. 8: e83145. PMID 24376657 DOI: 10.1371/journal.pone.0083145  1
2013 Shibata N, Carlin AF, Spann NJ, Saijo K, Morello CS, McDonald JG, Romanoski CE, Maurya MR, Kaikkonen MU, Lam MT, Crotti A, Reichart D, Fox JN, Quehenberger O, Raetz CR, ... ... Dennis EA, et al. 25-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages. The Journal of Biological Chemistry. 288: 35812-23. PMID 24189069 DOI: 10.1074/jbc.M113.519637  1
2013 Li P, Spann NJ, Kaikkonen MU, Lu M, Oh da Y, Fox JN, Bandyopadhyay G, Talukdar S, Xu J, Lagakos WS, Patsouris D, Armando A, Quehenberger O, Dennis EA, Watkins SM, et al. NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids. Cell. 155: 200-14. PMID 24074869 DOI: 10.1016/j.cell.2013.08.054  1
2013 Merrill AH, Dennis EA, McDonald JG, Fahy E. Lipidomics technologies at the end of the first decade and the beginning of the next. Advances in Nutrition (Bethesda, Md.). 4: 565-7. PMID 24038259 DOI: 10.3945/an.113.004333  1
2013 Magrioti V, Nikolaou A, Smyrniotou A, Shah I, Constantinou-Kokotou V, Dennis EA, Kokotos G. New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2. Bioorganic & Medicinal Chemistry. 21: 5823-9. PMID 23916152 DOI: 10.1016/j.bmc.2013.07.010  1
2013 Tam VC, Quehenberger O, Oshansky CM, Suen R, Armando AM, Treuting PM, Thomas PG, Dennis EA, Aderem A. Lipidomic profiling of influenza infection identifies mediators that induce and resolve inflammation. Cell. 154: 213-27. PMID 23827684 DOI: 10.1016/j.cell.2013.05.052  1
2013 Maurya MR, Gupta S, Li X, Fahy E, Dinasarapu AR, Sud M, Brown HA, Glass CK, Murphy RC, Russell DW, Dennis EA, Subramaniam S. Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages. Journal of Lipid Research. 54: 2525-42. PMID 23776196 DOI: 10.1194/jlr.M040212  1
2013 Hsu YH, Dumlao DS, Cao J, Dennis EA. Assessing phospholipase A2 activity toward cardiolipin by mass spectrometry. Plos One. 8: e59267. PMID 23533611 DOI: 10.1371/journal.pone.0059267  1
2013 Gregus AM, Dumlao DS, Wei SC, Norris PC, Catella LC, Meyerstein FG, Buczynski MW, Steinauer JJ, Fitzsimmons BL, Yaksh TL, Dennis EA. Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesia. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 1939-49. PMID 23382512 DOI: 10.1096/fj.12-217414  1
2013 Hsu YH, Bucher D, Cao J, Li S, Yang SW, Kokotos G, Woods VL, McCammon JA, Dennis EA. Fluoroketone inhibition of Ca(2+)-independent phospholipase A2 through binding pocket association defined by hydrogen/deuterium exchange and molecular dynamics. Journal of the American Chemical Society. 135: 1330-7. PMID 23256506 DOI: 10.1021/ja306490g  0.48
2013 Cao J, Burke JE, Dennis EA. Using hydrogen/deuterium exchange mass spectrometry to define the specific interactions of the phospholipase A2 superfamily with lipid substrates, inhibitors, and membranes. The Journal of Biological Chemistry. 288: 1806-13. PMID 23209293 DOI: 10.1074/jbc.R112.421909  1
2013 Cao J, Hsu YH, Li S, Woods VL, Dennis EA. Structural basis of specific interactions of Lp-PLA2 with HDL revealed by hydrogen deuterium exchange mass spectrometry. Journal of Lipid Research. 54: 127-33. PMID 23089916 DOI: 10.1194/jlr.M030221  1
2013 Hsu YH, Dumlao DS, Cao J, Dennis EA. Correction: Assessing phospholipase A2 activity toward cardiolipin by mass spectrometry (PLoS ONE) Plos One. 8. DOI: 10.1371/annotation/47607b18-ed69-4a08-8619-60c39bd83a13  1
2012 Sud M, Fahy E, Cotter D, Dennis EA, Subramaniam S. LIPID MAPS-Nature Lipidomics Gateway: An Online Resource for Students and Educators Interested in Lipids. Journal of Chemical Education. 89: 291-292. PMID 24764601 DOI: 10.1021/ed200088u  1
2012 Spann NJ, Garmire LX, McDonald JG, Myers DS, Milne SB, Shibata N, Reichart D, Fox JN, Shaked I, Heudobler D, Raetz CR, Wang EW, Kelly SL, Sullards MC, Murphy RC, ... ... Dennis EA, et al. Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses. Cell. 151: 138-52. PMID 23021221 DOI: 10.1016/j.cell.2012.06.054  1
2012 Pang XY, Cao J, Addington L, Lovell S, Battaile KP, Zhang N, Rao JL, Dennis EA, Moise AR. Structure/function relationships of adipose phospholipase A2 containing a cys-his-his catalytic triad. The Journal of Biological Chemistry. 287: 35260-74. PMID 22923616 DOI: 10.1074/jbc.M112.398859  1
2012 Dumlao DS, Cunningham AM, Wax LE, Norris PC, Hanks JH, Halpin R, Lett KM, Blaho VA, Mitchell WJ, Fritsche KL, Dennis EA, Brown CR. Dietary fish oil substitution alters the eicosanoid profile in ankle joints of mice during Lyme infection. The Journal of Nutrition. 142: 1582-9. PMID 22695969 DOI: 10.3945/jn.112.157883  1
2012 Norris PC, Dennis EA. Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling. Proceedings of the National Academy of Sciences of the United States of America. 109: 8517-22. PMID 22586114 DOI: 10.1073/pnas.1200189109  1
2012 Gregus AM, Doolen S, Dumlao DS, Buczynski MW, Takasusuki T, Fitzsimmons BL, Hua XY, Taylor BK, Dennis EA, Yaksh TL. Spinal 12-lipoxygenase-derived hepoxilin A3 contributes to inflammatory hyperalgesia via activation of TRPV1 and TRPA1 receptors. Proceedings of the National Academy of Sciences of the United States of America. 109: 6721-6. PMID 22493235 DOI: 10.1073/pnas.1110460109  1
2012 Grover RK, Cheng J, Peng Y, Jones TM, Ruiz DI, Ulevitch RJ, Glass JI, Dennis EA, Salomon DR, Lerner RA. The costimulatory immunogen LPS induces the B-Cell clones that infiltrate transplanted human kidneys. Proceedings of the National Academy of Sciences of the United States of America. 109: 6036-41. PMID 22492977 DOI: 10.1073/pnas.1202214109  1
2012 Sabidó E, Quehenberger O, Shen Q, Chang CY, Shah I, Armando AM, Andreyev A, Vitek O, Dennis EA, Aebersold R. Targeted proteomics of the eicosanoid biosynthetic pathway completes an integrated genomics-proteomics-metabolomics picture of cellular metabolism. Molecular & Cellular Proteomics : McP. 11: M111.014746. PMID 22361236 DOI: 10.1074/mcp.M111.014746  1
2012 Harkewicz R, Du H, Tong Z, Alkuraya H, Bedell M, Sun W, Wang X, Hsu YH, Esteve-Rudd J, Hughes G, Su Z, Zhang M, Lopes VS, Molday RS, Williams DS, ... Dennis EA, et al. Essential role of ELOVL4 protein in very long chain fatty acid synthesis and retinal function. The Journal of Biological Chemistry. 287: 11469-80. PMID 22199362 DOI: 10.1074/jbc.M111.256073  1
2012 Mouchlis VD, Michopoulou V, Constantinou-Kokotou V, Mavromoustakos T, Dennis EA, Kokotos G. Binding conformation of 2-oxoamide inhibitors to group IVA cytosolic phospholipase A2 determined by molecular docking combined with molecular dynamics. Journal of Chemical Information and Modeling. 52: 243-54. PMID 22196172 DOI: 10.1021/ci2005093  1
2012 Quehenberger O, Dennis EA. The authors reply New England Journal of Medicine. 366: 669. DOI: 10.1056/NEJMc1113671  1
2012 Dennis EA, Plückthun A. Phosphorus-31 NMR of Phospholipids in Micelles Phosphorous-31 Nmr: Principles and Applications. 423-446. DOI: 10.1016/B978-0-08-091841-9.50019-9  0.96
2011 Quehenberger O, Dennis EA. The human plasma lipidome. The New England Journal of Medicine. 365: 1812-23. PMID 22070478 DOI: 10.1056/NEJMra1104901  1
2011 Christianson CA, Dumlao DS, Stokes JA, Dennis EA, Svensson CI, Corr M, Yaksh TL. Spinal TLR4 mediates the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis. Pain. 152: 2881-91. PMID 22019135 DOI: 10.1016/j.pain.2011.09.020  1
2011 Dennis EA, Cao J, Hsu YH, Magrioti V, Kokotos G. Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chemical Reviews. 111: 6130-85. PMID 21910409 DOI: 10.1021/cr200085w  1
2011 López-Vales R, Ghasemlou N, Redensek A, Kerr BJ, Barbayianni E, Antonopoulou G, Baskakis C, Rathore KI, Constantinou-Kokotou V, Stephens D, Shimizu T, Dennis EA, Kokotos G, David S. Phospholipase A2 superfamily members play divergent roles after spinal cord injury. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 4240-52. PMID 21868473 DOI: 10.1096/fj.11-183186  1
2011 Quehenberger O, Armando AM, Dennis EA. High sensitivity quantitative lipidomics analysis of fatty acids in biological samples by gas chromatography-mass spectrometry. Biochimica Et Biophysica Acta. 1811: 648-56. PMID 21787881 DOI: 10.1016/j.bbalip.2011.07.006  1
2011 Dumlao DS, Buczynski MW, Norris PC, Harkewicz R, Dennis EA. High-throughput lipidomic analysis of fatty acid derived eicosanoids and N-acylethanolamines. Biochimica Et Biophysica Acta. 1811: 724-36. PMID 21689782 DOI: 10.1016/j.bbalip.2011.06.005  1
2011 Norris PC, Reichart D, Dumlao DS, Glass CK, Dennis EA. Specificity of eicosanoid production depends on the TLR-4-stimulated macrophage phenotype. Journal of Leukocyte Biology. 90: 563-74. PMID 21653236 DOI: 10.1189/jlb.0311153  1
2011 Quehenberger O, Yamashita T, Armando AM, Dennis EA, Palinski W. Effect of gestational hypercholesterolemia and maternal immunization on offspring plasma eicosanoids. American Journal of Obstetrics and Gynecology. 205: 156.e15-25. PMID 21621186 DOI: 10.1016/j.ajog.2011.03.044  1
2011 Cao J, Hsu YH, Li S, Woods VL, Dennis EA. Lipoprotein-associated phospholipase A(2) interacts with phospholipid vesicles via a surface-disposed hydrophobic α-helix. Biochemistry. 50: 5314-21. PMID 21553808 DOI: 10.1021/bi101916w  1
2011 Harkewicz R, Dennis EA. Applications of mass spectrometry to lipids and membranes. Annual Review of Biochemistry. 80: 301-25. PMID 21469951 DOI: 10.1146/annurev-biochem-060409-092612  1
2010 Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, Myers DS, Glass CK, Hardiman G, Reichart D, Merrill AH, Sullards MC, Wang E, Murphy RC, Raetz CR, et al. A mouse macrophage lipidome. The Journal of Biological Chemistry. 285: 39976-85. PMID 20923771 DOI: 10.1074/jbc.M110.182915  1
2010 Fang L, Harkewicz R, Hartvigsen K, Wiesner P, Choi SH, Almazan F, Pattison J, Deer E, Sayaphupha T, Dennis EA, Witztum JL, Tsimikas S, Miller YI. Oxidized cholesteryl esters and phospholipids in zebrafish larvae fed a high cholesterol diet: macrophage binding and activation. The Journal of Biological Chemistry. 285: 32343-51. PMID 20710028 DOI: 10.1074/jbc.M110.137257  1
2010 Quehenberger O, Armando AM, Brown AH, Milne SB, Myers DS, Merrill AH, Bandyopadhyay S, Jones KN, Kelly S, Shaner RL, Sullards CM, Wang E, Murphy RC, Barkley RM, Leiker TJ, ... ... Dennis EA, et al. Lipidomics reveals a remarkable diversity of lipids in human plasma. Journal of Lipid Research. 51: 3299-305. PMID 20671299 DOI: 10.1194/jlr.M009449  1
2010 Saito O, Svensson CI, Buczynski MW, Wegner K, Hua XY, Codeluppi S, Schaloske RH, Deems RA, Dennis EA, Yaksh TL. Spinal glial TLR4-mediated nociception and production of prostaglandin E(2) and TNF. British Journal of Pharmacology. 160: 1754-64. PMID 20649577 DOI: 10.1111/j.1476-5381.2010.00811.x  1
2010 Andreyev AY, Fahy E, Guan Z, Kelly S, Li X, McDonald JG, Milne S, Myers D, Park H, Ryan A, Thompson BM, Wang E, Zhao Y, Brown HA, Merrill AH, ... ... Dennis EA, et al. Subcellular organelle lipidomics in TLR-4-activated macrophages. Journal of Lipid Research. 51: 2785-97. PMID 20574076 DOI: 10.1194/jlr.M008748  1
2010 Buczynski MW, Svensson CI, Dumlao DS, Fitzsimmons BL, Shim JH, Scherbart TJ, Jacobsen FE, Hua XY, Yaksh TL, Dennis EA. Inflammatory hyperalgesia induces essential bioactive lipid production in the spinal cord. Journal of Neurochemistry. 114: 981-93. PMID 20492349 DOI: 10.1111/j.1471-4159.2010.06815.x  1
2010 Kokotos G, Hsu YH, Burke JE, Baskakis C, Kokotos CG, Magrioti V, Dennis EA. Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. Journal of Medicinal Chemistry. 53: 3602-10. PMID 20369880 DOI: 10.1021/jm901872v  1
2010 Harmon GS, Dumlao DS, Ng DT, Barrett KE, Dennis EA, Dong H, Glass CK. Pharmacological correction of a defect in PPAR-gamma signaling ameliorates disease severity in Cftr-deficient mice. Nature Medicine. 16: 313-8. PMID 20154695 DOI: 10.1038/nm.2101  1
2010 Andreyev AY, Shen Z, Guan Z, Ryan A, Fahy E, Subramaniam S, Raetz CR, Briggs S, Dennis EA. Application of proteomic marker ensembles to subcellular organelle identification. Molecular & Cellular Proteomics : McP. 9: 388-402. PMID 19884172 DOI: 10.1074/mcp.M900432-MCP200  1
2010 Balsinde J, Dennis EA. Role of phospholipase a2 forms in arachidonic acid mobilization and eicosanoid generation Handbook of Cell Signaling, 2/E. 2: 1213-1217. DOI: 10.1016/B978-0-12-374145-5.00149-2  1
2010 Bradshaw RA, Dennis EA. Cell signaling. yesterday, today, and tomorrow Handbook of Cell Signaling, 2/E. 1: 1-4. DOI: 10.1016/B978-0-12-374145-5.00001-2  1
2009 Blaho VA, Buczynski MW, Dennis EA, Brown CR. Cyclooxygenase-1 orchestrates germinal center formation and antibody class-switch via regulation of IL-17. Journal of Immunology (Baltimore, Md. : 1950). 183: 5644-53. PMID 19843949 DOI: 10.4049/jimmunol.0901499  1
2009 Hsu YH, Burke JE, Li S, Woods VL, Dennis EA. Localizing the membrane binding region of Group VIA Ca2+-independent phospholipase A2 using peptide amide hydrogen/deuterium exchange mass spectrometry. The Journal of Biological Chemistry. 284: 23652-61. PMID 19556238 DOI: 10.1074/jbc.M109.021857  1
2009 Grkovich A, Dennis EA. Phosphatidic acid phosphohydrolase in the regulation of inflammatory signaling. Advances in Enzyme Regulation. 49: 114-20. PMID 19534028 DOI: 10.1016/j.advenzreg.2009.01.005  1
2009 Blaho VA, Buczynski MW, Brown CR, Dennis EA. Lipidomic analysis of dynamic eicosanoid responses during the induction and resolution of Lyme arthritis. The Journal of Biological Chemistry. 284: 21599-612. PMID 19487688 DOI: 10.1074/jbc.M109.003822  1
2009 Gupta S, Maurya MR, Stephens DL, Dennis EA, Subramaniam S. An integrated model of eicosanoid metabolism and signaling based on lipidomics flux analysis. Biophysical Journal. 96: 4542-51. PMID 19486676 DOI: 10.1016/j.bpj.2009.03.011  1
2009 Burke JE, Babakhani A, Gorfe AA, Kokotos G, Li S, Woods VL, McCammon JA, Dennis EA. Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry. Journal of the American Chemical Society. 131: 8083-91. PMID 19459633 DOI: 10.1021/ja900098y  1
2009 Barbayianni E, Stephens D, Grkovich A, Magrioti V, Hsu YH, Dolatzas P, Kalogiannidis D, Dennis EA, Kokotos G. 2-Oxoamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudodipeptides. Bioorganic & Medicinal Chemistry. 17: 4833-43. PMID 19443224 DOI: 10.1016/j.bmc.2009.03.069  1
2009 Dennis EA, Witztum JL. Fifty years of research on lipids. Journal of Lipid Research. 50: S1. PMID 19346336 DOI: 10.1194/jlr.SUPPEDITORIAL-50/4-JLR  1
2009 Buczynski MW, Dumlao DS, Dennis EA. Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology. Journal of Lipid Research. 50: 1015-38. PMID 19244215 DOI: 10.1194/jlr.R900004-JLR200  1
2009 Grkovich A, Armando A, Quehenberger O, Dennis EA. TLR-4 mediated group IVA phospholipase A(2) activation is phosphatidic acid phosphohydrolase 1 and protein kinase C dependent. Biochimica Et Biophysica Acta. 1791: 975-82. PMID 19230851 DOI: 10.1016/j.bbalip.2009.02.002  1
2009 Kalyvas A, Baskakis C, Magrioti V, Constantinou-Kokotou V, Stephens D, López-Vales R, Lu JQ, Yong VW, Dennis EA, Kokotos G, David S. Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis. Brain : a Journal of Neurology. 132: 1221-35. PMID 19218359 DOI: 10.1093/brain/awp002  1
2009 Dennis EA. Lipidomics joins the omics evolution. Proceedings of the National Academy of Sciences of the United States of America. 106: 2089-90. PMID 19211786 DOI: 10.1073/pnas.0812636106  1
2009 Dennis EA. Founding, early history, and transformation of the Journal for Lipid Research to an American Society of Biochemistry and Molecular Biology journal. Journal of Lipid Research. 50: S3-8. PMID 19116414 DOI: 10.1194/jlr.R800093-JLR200  1
2009 Fahy E, Subramaniam S, Murphy RC, Nishijima M, Raetz CR, Shimizu T, Spener F, van Meer G, Wakelam MJ, Dennis EA. Update of the LIPID MAPS comprehensive classification system for lipids. Journal of Lipid Research. 50: S9-14. PMID 19098281 DOI: 10.1194/jlr.R800095-JLR200  1
2009 Burke JE, Dennis EA. Phospholipase A2 structure/function, mechanism, and signaling. Journal of Lipid Research. 50: S237-42. PMID 19011112 DOI: 10.1194/jlr.R800033-JLR200  1
2009 Burke JE, Dennis EA. Phospholipase A2 biochemistry. Cardiovascular Drugs and Therapy / Sponsored by the International Society of Cardiovascular Pharmacotherapy. 23: 49-59. PMID 18931897 DOI: 10.1007/s10557-008-6132-9  1
2009 Prévost N, Mitsios JV, Kato H, Burke JE, Dennis EA, Shimizu T, Shattil SJ. Group IVA cytosolic phospholipase A2 (cPLA2alpha) and integrin alphaIIbbeta3 reinforce each other's functions during alphaIIbbeta3 signaling in platelets. Blood. 113: 447-57. PMID 18840708 DOI: 10.1182/blood-2008-06-162032  1
2008 Baskakis C, Magrioti V, Cotton N, Stephens D, Constantinou-Kokotou V, Dennis EA, Kokotos G. Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes. Journal of Medicinal Chemistry. 51: 8027-37. PMID 19053783 DOI: 10.1021/jm800649q  1
2008 Quehenberger O, Armando A, Dumlao D, Stephens DL, Dennis EA. Lipidomics analysis of essential fatty acids in macrophages. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 79: 123-9. PMID 18996688 DOI: 10.1016/j.plefa.2008.09.021  1
2008 Antonopoulou G, Barbayianni E, Magrioti V, Cotton N, Stephens D, Constantinou-Kokotou V, Dennis EA, Kokotos G. Structure-activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A(2) enzymes. Bioorganic & Medicinal Chemistry. 16: 10257-69. PMID 18993078 DOI: 10.1016/j.bmc.2008.10.046  1
2008 Burke JE, Hsu YH, Deems RA, Li S, Woods VL, Dennis EA. A phospholipid substrate molecule residing in the membrane surface mediates opening of the lid region in group IVA cytosolic phospholipase A2. The Journal of Biological Chemistry. 283: 31227-36. PMID 18753135 DOI: 10.1074/jbc.M804492200  1
2008 López-Vales R, Navarro X, Shimizu T, Baskakis C, Kokotos G, Constantinou-Kokotou V, Stephens D, Dennis EA, David S. Intracellular phospholipase A(2) group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury. Brain : a Journal of Neurology. 131: 2620-31. PMID 18718965 DOI: 10.1093/brain/awn188  1
2008 Jacobsen FE, Buczynski MW, Dennis EA, Cohen SM. A macrophage cell model for selective metalloproteinase inhibitor design. Chembiochem : a European Journal of Chemical Biology. 9: 2087-95. PMID 18666306 DOI: 10.1002/cbic.200800148  1
2008 Antonopoulou G, Magrioti V, Stephens D, Constantinou-Kokotou V, Dennis EA, Kokotos G. Synthesis of 2-oxoamides based on sulfonamide analogs of gamma-amino acids and their activity on phospholipase A2. Journal of Peptide Science : An Official Publication of the European Peptide Society. 14: 1111-20. PMID 18618424 DOI: 10.1002/psc.1048  1
2008 Burke JE, Karbarz MJ, Deems RA, Li S, Woods VL, Dennis EA. Interaction of group IA phospholipase A2 with metal ions and phospholipid vesicles probed with deuterium exchange mass spectrometry. Biochemistry. 47: 6451-9. PMID 18500818 DOI: 10.1021/bi8000962  1
2008 Harkewicz R, Hartvigsen K, Almazan F, Dennis EA, Witztum JL, Miller YI. Cholesteryl ester hydroperoxides are biologically active components of minimally oxidized low density lipoprotein. The Journal of Biological Chemistry. 283: 10241-51. PMID 18263582 DOI: 10.1074/jbc.M709006200  1
2008 Hsu YH, Burke JE, Stephens DL, Deems RA, Li S, Asmus KM, Woods VL, Dennis EA. Calcium binding rigidifies the C2 domain and the intradomain interaction of GIVA phospholipase A2 as revealed by hydrogen/deuterium exchange mass spectrometry. The Journal of Biological Chemistry. 283: 9820-7. PMID 18211893 DOI: 10.1074/jbc.M708143200  1
2008 Dennis EA, Witztum JL. New Commentary section to highlight significant JLR articles Journal of Lipid Research. 49: 1. DOI: 10.1194/jlr.E700010-JLR200  1
2008 Haunerland NH, Dennis EA. The scientific work of Fritz Spener European Journal of Lipid Science and Technology. 110: 3-4. DOI: 10.1002/ejlt.200890000  1
2007 Schmelzer K, Fahy E, Subramaniam S, Dennis EA. The lipid maps initiative in lipidomics. Methods in Enzymology. 432: 171-83. PMID 17954217 DOI: 10.1016/S0076-6879(07)32007-7  1
2007 Deems R, Buczynski MW, Bowers-Gentry R, Harkewicz R, Dennis EA. Detection and quantitation of eicosanoids via high performance liquid chromatography-electrospray ionization-mass spectrometry. Methods in Enzymology. 432: 59-82. PMID 17954213 DOI: 10.1016/S0076-6879(07)32003-X  1
2007 Six DA, Barbayianni E, Loukas V, Constantinou-Kokotou V, Hadjipavlou-Litina D, Stephens D, Wong AC, Magrioti V, Moutevelis-Minakakis P, Baker SF, Dennis EA, Kokotos G. Structure-activity relationship of 2-oxoamide inhibition of group IVA cytosolic phospholipase A2 and group V secreted phospholipase A2. Journal of Medicinal Chemistry. 50: 4222-35. PMID 17672443 DOI: 10.1021/jm0613673  1
2007 Moutevelis-Minakakis P, Neokosmidi A, Filippakou M, Stephens D, Dennis EA, Kokotos G. Synthesis of lipophilic 2-oxoamides based on gamma-aminobutyric and delta-aminovaleric analogues and their activity against phospholipase A2. Journal of Peptide Science : An Official Publication of the European Peptide Society. 13: 634-41. PMID 17631670 DOI: 10.1002/psc.889  1
2007 Buczynski MW, Stephens DL, Bowers-Gentry RC, Grkovich A, Deems RA, Dennis EA. TLR-4 and sustained calcium agonists synergistically produce eicosanoids independent of protein synthesis in RAW264.7 cells. The Journal of Biological Chemistry. 282: 22834-47. PMID 17535806 DOI: 10.1074/jbc.M701831200  1
2007 Harkewicz R, Fahy E, Andreyev A, Dennis EA. Arachidonate-derived dihomoprostaglandin production observed in endotoxin-stimulated macrophage-like cells. The Journal of Biological Chemistry. 282: 2899-910. PMID 17135246 DOI: 10.1074/jbc.M610067200  1
2007 Sud M, Fahy E, Cotter D, Brown A, Dennis EA, Glass CK, Merrill AH, Murphy RC, Raetz CR, Russell DW, Subramaniam S. LMSD: LIPID MAPS structure database. Nucleic Acids Research. 35: D527-32. PMID 17098933 DOI: 10.1093/nar/gkl838  1
2006 Schaloske RH, Dennis EA. The phospholipase A2 superfamily and its group numbering system. Biochimica Et Biophysica Acta. 1761: 1246-59. PMID 16973413 DOI: 10.1016/j.bbalip.2006.07.011  1
2006 Grkovich A, Johnson CA, Buczynski MW, Dennis EA. Lipopolysaccharide-induced cyclooxygenase-2 expression in human U937 macrophages is phosphatidic acid phosphohydrolase-1-dependent. The Journal of Biological Chemistry. 281: 32978-87. PMID 16950767 DOI: 10.1074/jbc.M605935200  1
2006 Stephens D, Barbayianni E, Constantinou-Kokotou V, Peristeraki A, Six DA, Cooper J, Harkewicz R, Deems RA, Dennis EA, Kokotos G. Differential inhibition of group IVA and group VIA phospholipases A2 by 2-oxoamides. Journal of Medicinal Chemistry. 49: 2821-8. PMID 16640343 DOI: 10.1021/jm050993h  1
2006 Raetz CR, Garrett TA, Reynolds CM, Shaw WA, Moore JD, Smith DC, Ribeiro AA, Murphy RC, Ulevitch RJ, Fearns C, Reichart D, Glass CK, Benner C, Subramaniam S, Harkewicz R, ... ... Dennis EA, et al. Kdo2-Lipid A of Escherichia coli, a defined endotoxin that activates macrophages via TLR-4. Journal of Lipid Research. 47: 1097-111. PMID 16479018 DOI: 10.1194/jlr.M600027-JLR200  1
2006 Yaksh TL, Kokotos G, Svensson CI, Stephens D, Kokotos CG, Fitzsimmons B, Hadjipavlou-Litina D, Hua XY, Dennis EA. Systemic and intrathecal effects of a novel series of phospholipase A2 inhibitors on hyperalgesia and spinal prostaglandin E2 release. The Journal of Pharmacology and Experimental Therapeutics. 316: 466-75. PMID 16203828 DOI: 10.1124/jpet.105.091686  1
2006 Dennis EA, Witztum JL. A new category in JLR: Patient-Oriented Research articles Journal of Lipid Research. 47: 1117. DOI: 10.1194/jlr.E600001-JLR200  1
2005 Winstead MV, Lucas KK, Dennis EA. Group IV cytosolic phospholipase A2 mediates arachidonic acid release in H9c2 rat cardiomyocyte cells in response to hydrogen peroxide. Prostaglandins & Other Lipid Mediators. 78: 55-66. PMID 16303605 DOI: 10.1016/j.prostaglandins.2005.03.004  1
2005 Kessen UA, Schaloske RH, Stephens DL, Killermann Lucas K, Dennis EA. PGE2 release is independent of upregulation of Group V phospholipase A2 during long-term stimulation of P388D1 cells with LPS. Journal of Lipid Research. 46: 2488-96. PMID 16150819 DOI: 10.1194/jlr.M500325-JLR200  1
2005 Lucas KK, Dennis EA. Distinguishing phospholipase A2 types in biological samples by employing group-specific assays in the presence of inhibitors. Prostaglandins & Other Lipid Mediators. 77: 235-48. PMID 16099408 DOI: 10.1016/j.prostaglandins.2005.02.004  1
2005 Rapaka RS, Piomelli D, Spiegel S, Bazan N, Dennis EA. Targeted lipidomics: signaling lipids and drugs of abuse. Prostaglandins & Other Lipid Mediators. 77: 223-34. PMID 16099407 DOI: 10.1016/j.prostaglandins.2005.06.005  1
2005 Shirai Y, Balsinde J, Dennis EA. Localization and functional interrelationships among cytosolic Group IV, secreted Group V, and Ca2+-independent Group VI phospholipase A2s in P388D1 macrophages using GFP/RFP constructs. Biochimica Et Biophysica Acta. 1735: 119-29. PMID 15967714 DOI: 10.1016/j.bbalip.2005.05.005  1
2005 Svensson CI, Lucas KK, Hua XY, Powell HC, Dennis EA, Yaksh TL. Spinal phospholipase A2 in inflammatory hyperalgesia: role of the small, secretory phospholipase A2. Neuroscience. 133: 543-53. PMID 15885922 DOI: 10.1016/j.neuroscience.2005.01.024  1
2005 Fahy E, Subramaniam S, Brown HA, Glass CK, Merrill AH, Murphy RC, Raetz CR, Russell DW, Seyama Y, Shaw W, Shimizu T, Spener F, van Meer G, VanNieuwenhze MS, White SH, ... ... Dennis EA, et al. A comprehensive classification system for lipids. Journal of Lipid Research. 46: 839-61. PMID 15722563 DOI: 10.1194/jlr.E400004-JLR200  1
2005 Boullier A, Friedman P, Harkewicz R, Hartvigsen K, Green SR, Almazan F, Dennis EA, Steinberg D, Witztum JL, Quehenberger O. Phosphocholine as a pattern recognition ligand for CD36. Journal of Lipid Research. 46: 969-76. PMID 15722561 DOI: 10.1194/jlr.M400496-JLR200  1
2005 Schaloske RH, Provins JW, Kessen UA, Dennis EA. Molecular characterization of the lipopolysaccharide/platelet activating factor- and zymosan-induced pathways leading to prostaglandin production in P388D1 macrophages. Biochimica Et Biophysica Acta. 1687: 64-75. PMID 15708354 DOI: 10.1016/j.bbalip.2004.11.005  1
2005 Lucas KK, Svensson CI, Hua XY, Yaksh TL, Dennis EA. Spinal phospholipase A2 in inflammatory hyperalgesia: role of group IVA cPLA2. British Journal of Pharmacology. 144: 940-52. PMID 15685208 DOI: 10.1038/sj.bjp.0706116  1
2005 Constantinou-Kokotou V, Peristeraki A, Kokotos CG, Six DA, Dennis EA. Synthesis and activity of 2-oxoamides containing long chain beta-amino acids. Journal of Peptide Science : An Official Publication of the European Peptide Society. 11: 431-5. PMID 15635664 DOI: 10.1002/psc.628  1
2004 Kokotos G, Six DA, Loukas V, Smith T, Constantinou-Kokotou V, Hadjipavlou-Litina D, Kotsovolou S, Chiou A, Beltzner CC, Dennis EA. Inhibition of group IVA cytosolic phospholipase A2 by novel 2-oxoamides in vitro, in cells, and in vivo. Journal of Medicinal Chemistry. 47: 3615-28. PMID 15214789 DOI: 10.1021/jm030485c  1
2004 Lucas KK, Dennis EA. The ABC's of Group IV cytosolic phospholipase A2. Biochimica Et Biophysica Acta. 1636: 213-8. PMID 15164769 DOI: 10.1016/j.bbalip.2003.12.009  1
2004 Boegeman SC, Deems RA, Dennis EA. Phospholipid binding and the activation of group IA secreted phospholipase A2. Biochemistry. 43: 3907-16. PMID 15049698 DOI: 10.1021/bi035921b  1
2003 Balboa MA, Shirai Y, Gaietta G, Ellisman MH, Balsinde J, Dennis EA. Localization of group V phospholipase A2 in caveolin-enriched granules in activated P388D1 macrophage-like cells. The Journal of Biological Chemistry. 278: 48059-65. PMID 12963740 DOI: 10.1074/jbc.M305904200  1
2003 Phillips RM, Six DA, Dennis EA, Ghosh P. In vivo phospholipase activity of the Pseudomonas aeruginosa cytotoxin ExoU and protection of mammalian cells with phospholipase A2 inhibitors. The Journal of Biological Chemistry. 278: 41326-32. PMID 12915403 DOI: 10.1074/jbc.M302472200  1
2003 Six DA, Dennis EA. Essential Ca(2+)-independent role of the group IVA cytosolic phospholipase A(2) C2 domain for interfacial activity. The Journal of Biological Chemistry. 278: 23842-50. PMID 12672805 DOI: 10.1074/jbc.M301386200  1
2003 Dennis EA, Witztum JL. Journal of Lipid Research: The New Era in Lipid Science and Medicine Journal of Lipid Research. 44: 1267. DOI: 10.1194/jlr.E300002-JLR200  1
2003 Balsinde J, Dennis EA. Phospholipase A2 Signaling and Arachidonic Acid Release Handbook of Cell Signaling. 2: 261-263. DOI: 10.1016/B978-012124546-7/50527-1  0.36
2002 Whiles JA, Deems R, Vold RR, Dennis EA. Bicelles in structure-function studies of membrane-associated proteins. Bioorganic Chemistry. 30: 431-42. PMID 12642127 DOI: 10.1016/S0045-2068(02)00527-8  1
2002 Balboa MA, Varela-Nieto I, Killermann Lucas K, Dennis EA. Expression and function of phospholipase A(2) in brain. Febs Letters. 531: 12-7. PMID 12401195 DOI: 10.1016/S0014-5793(02)03481-6  1
2002 Balsinde J, Winstead MV, Dennis EA. Phospholipase A(2) regulation of arachidonic acid mobilization. Febs Letters. 531: 2-6. PMID 12401193 DOI: 10.1016/S0014-5793(02)03413-0  1
2002 Kokotos G, Kotsovolou S, Six DA, Constantinou-Kokotou V, Beltzner CC, Dennis EA. Novel 2-oxoamide inhibitors of human group IVA phospholipase A(2). Journal of Medicinal Chemistry. 45: 2891-3. PMID 12086476 DOI: 10.1021/jm025538p  1
2002 Friedman P, Horkko S, Steinberg D, Witztum JL, Dennis EA. Correlation of antiphospholipid antibody recognition with the structure of synthetic oxidized phospholipids. Importance of Schiff base formation and aldol condensation. The Journal of Biological Chemistry. 277: 7010-20. PMID 11744722 DOI: 10.1074/jbc.M108860200  1
2001 Boullier A, Bird DA, Chang MK, Dennis EA, Friedman P, Gillotre-Taylor K, Hörkkö S, Palinski W, Quehenberger O, Shaw P, Steinberg D, Terpstra V, Witztum JL. Scavenger receptors, oxidized LDL, and atherosclerosis. Annals of the New York Academy of Sciences. 947: 214-22; discussion 2. PMID 11795269  1
2001 Bernatchez PN, Winstead MV, Dennis EA, Sirois MG. VEGF stimulation of endothelial cell PAF synthesis is mediated by group V 14 kDa secretory phospholipase A 2 British Journal of Pharmacology. 134: 197-205. PMID 11522612  1
2001 Balboa MA, Balsinde J, Dennis EA. Inflammatory activation of prostaglandin production by microglial cells antagonized by amyloid peptide Biochemical and Biophysical Research Communications. 280: 558-560. PMID 11162555 DOI: 10.1006/bbrc.2000.4156  1
2000 Winstead MV, Balsinde J, Dennis EA. Calcium-independent phospholipase A2: Structure and function Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids. 1488: 28-39. PMID 11080674 DOI: 10.1016/S1388-1981(00)00107-4  1
2000 Six DA, Dennis EA. The expanding superfamily of phospholipase A(2) enzymes: classification and characterization. Biochimica Et Biophysica Acta. 1488: 1-19. PMID 11080672 DOI: 10.1016/S1388-1981(00)00105-0  1
2000 Lefkowitz LJ, Shinohara H, Dennis EA. Human group-V phospholipase-A2 expression in Pichia pastoris and its role in eicosanoid generation Ernst Schering Research Foundation Workshop. 25-52. PMID 10943326  1
2000 Balsinde J, Balboa MA, Dennis EA. Group IV cytosolic phospholipase A2 activation by diacylglycerol pyrophosphate in murine P388D1 macrophages Annals of the New York Academy of Sciences. 905: 11-15. PMID 10818437  1
2000 Balsinde J, Balboa MA, Dennis EA. Identification of a third pathway for arachidonic acid mobilization and prostaglandin production in activated P388D macrophage-like cells Journal of Biological Chemistry. 275: 22544-22549. PMID 10811815 DOI: 10.1074/jbc.M910163199  1
2000 Balsinde J, Balboa MA, Li WH, Llopis J, Dennis EA. Cellular regulation of cytosolic group IV phospholipase A2 by phosphatidylinositol bisphosphate levels Journal of Immunology. 164: 5398-5402. PMID 10799904  1
2000 Wang A, Johnson CA, Jones Y, Ellisman MH, Dennis EA. Subcellular localization and PKC-dependent regulation of the human lysophospholipase A/acyl-protein thioesterase in WISH cells. Biochimica Et Biophysica Acta. 1484: 207-14. PMID 10760470 DOI: 10.1016/S1388-1981(00)00020-2  1
2000 Johansen B, Rakkestad K, Balboa MA, Dennis EA. Expression of cytosolic and secreted forms of phospholipase A2 and cyclooxygenases in human placenta, fetal membranes, and chorionic cell lines Prostaglandins and Other Lipid Mediators. 60: 119-125. PMID 10751642 DOI: 10.1016/S0090-6980(99)00057-X  1
2000 Boullier A, Gillotte KL, Hörkkö S, Green SR, Friedman P, Dennis EA, Witztum JL, Steinberg D, Quehenberger O. The binding of oxidized low density lipoprotein to mouse CD36 is mediated in part by oxidized phospholipids that are associated with both the lipid and protein moieties of the lipoprotein. The Journal of Biological Chemistry. 275: 9163-9. PMID 10734051 DOI: 10.1074/jbc.275.13.9163  1
2000 Bianco ID, Balsinde J, Beltramo DM, Castagna LF, Landa CA, Dennis EA. Chitosan-induced phospholipase A2 activation and arachidonic acid mobilization in P388D1 macrophages. Febs Letters. 466: 292-4. PMID 10682846 DOI: 10.1016/S0014-5793(00)01089-9  1
2000 Dennis EA. Phospholipase A2 in eicosanoid generation American Journal of Respiratory and Critical Care Medicine. 161: S32-S35. PMID 10673223  1
2000 Balsinde J, Balboa MA, Yedgar S, Dennis EA. Group V phospholipase A2-mediated oleic acid mobilization in lipopolysaccharide-stimulated P388D1 macrophages Journal of Biological Chemistry. 275: 4783-4786. PMID 10671511 DOI: 10.1074/jbc.275.7.4783  1
2000 Balboa MA, Balsinde J, Dennis EA. Phosphorylation of cytosolic group IV phospholipase A2 is necessary but not sufficient for arachidonic acid release in P388D1 macrophages Biochemical and Biophysical Research Communications. 267: 145-148. PMID 10623589 DOI: 10.1006/bbrc.1999.1964  1
1999 Balboa MA, Balsinde J, Johnson CA, Dennis EA. Regulation of arachidonic acid mobilization in lipopolysaccharide-activated P388D(1) macrophages by adenosine triphosphate. The Journal of Biological Chemistry. 274: 36764-8. PMID 10593984 DOI: 10.1074/jbc.274.51.36764  1
1999 Lefkowitz LJ, Deems RA, Dennis EA. Expression of group IA phospholipase A2 in Pichia pastoris: Identification of a phosphatidylcholine activator site using site-directed mutagenesis Biochemistry. 38: 14174-14184. PMID 10571991 DOI: 10.1021/bi991432t  1
1999 Johnson CA, Balboa MA, Balsinde J, Dennis EA. Regulation of cyclooxygenase-2 expression by phosphatidate phosphohydrolase in human amnionic WISH cells. The Journal of Biological Chemistry. 274: 27689-93. PMID 10488110 DOI: 10.1074/jbc.274.39.27689  1
1999 Balsinde J, Shinohara H, Lefkowitz LJ, Johnson CA, Balboa MA, Dennis EA. Group V phospholipase A(2)-dependent induction of cyclooxygenase-2 in macrophages. The Journal of Biological Chemistry. 274: 25967-70. PMID 10473537 DOI: 10.1074/jbc.274.37.25967  1
1999 Yang HC, Mosior M, Ni B, Dennis EA. Regional distribution, ontogeny, purification, and characterization of the Ca2+-independent phospholipase A2 from rat brain Journal of Neurochemistry. 73: 1278-1287. PMID 10461922 DOI: 10.1046/j.1471-4159.1999.0731278.x  1
1999 Ghomashchi F, Loo R, Balsinde J, Bartoli F, Apitz-Castro R, Clark JD, Dennis EA, Gelb MH. Trifluoromethyl ketones and methyl fluorophosphonates as inhibitors of group IV and VI phospholipases A2: Structure-function studies with vesicle, micelle, and membrane assays Biochimica Et Biophysica Acta - Biomembranes. 1420: 45-56. PMID 10446289 DOI: 10.1016/S0005-2736(99)00056-5  1
1999 Wang A, Dennis EA. Mammalian lysophospholipases Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids. 1439: 1-16. PMID 10395961 DOI: 10.1016/S1388-1981(99)00063-3  1
1999 Chang MK, Bergmark C, Laurila A, Hörkkö S, Han KH, Friedman P, Dennis EA, Witztum JL. Monoclonal antibodies against oxidized low-density lipoprotein bind to apoptotic cells and inhibit their phagocytosis by elicited macrophages: evidence that oxidation-specific epitopes mediate macrophage recognition. Proceedings of the National Academy of Sciences of the United States of America. 96: 6353-8. PMID 10339591 DOI: 10.1073/pnas.96.11.6353  1
1999 Bird DA, Gillotte KL, Horkko S, Friedman P, Dennis EA, Witztum JL, Steinberg D. Receptors for oxidized low-density lipoprotein on elicited mouse peritoneal macrophages can recognize both the modified lipid moieties and the modified protein moieties: Implications with respect to macrophage recognition of apoptotic cells Proceedings of the National Academy of Sciences of the United States of America. 96: 6347-6352. PMID 10339590 DOI: 10.1073/pnas.96.11.6347  1
1999 Balsinde J, Balboa MA, Insel PA, Dennis EA. Regulation and inhibition of phospholipase A2. Annual Review of Pharmacology and Toxicology. 39: 175-89. PMID 10331081 DOI: 10.1146/annurev.pharmtox.39.1.175  1
1999 Yang HC, Mosior M, Johnson CA, Chen Y, Dennis EA. Group-specific assays that distinguish between the four major types of mammalian phospholipase A2. Analytical Biochemistry. 269: 278-88. PMID 10221999 DOI: 10.1006/abio.1999.4053  1
1999 Shinohara H, Balboa MA, Johnson CA, Balsinde J, Dennis EA. Regulation of delayed prostaglandin production in activated P388D1 macrophages by group IV cytosolic and group V secretory phospholipase A2s. The Journal of Biological Chemistry. 274: 12263-8. PMID 10212194 DOI: 10.1074/jbc.274.18.12263  1
1999 Wang A, Yang HC, Friedman P, Johnson CA, Dennis EA. A specific human lysophospholipase: cDNA cloning, tissue distribution and kinetic characterization. Biochimica Et Biophysica Acta. 1437: 157-69. PMID 10064899 DOI: 10.1016/S1388-1981(99)00012-8  1
1999 Canne LE, Botti P, Simon RJ, Chen Y, Dennis EA, Kent SBH. Chemical protein synthesis by solid phase ligation of unprotected peptide segments Journal of the American Chemical Society. 121: 8720-8727. DOI: 10.1021/ja9836287  1
1998 Mosior M, Six DA, Dennis EA. Group IV cytosolic phospholipase A2 binds with high affinity and specificity to phosphatidylinositol 4,5-bisphosphate resulting in dramatic increases in activity. The Journal of Biological Chemistry. 273: 2184-91. PMID 9442060 DOI: 10.1074/jbc.273.4.2184  1
1986 Plückthun A, DeBony J, Fanni T, Dennis EA. Conformation of fatty acyl chains in alpha- and beta-phosphatidylcholine and phosphatidylethanolamine derivatives in sonicated vesicles. Biochimica Et Biophysica Acta. 856: 144-54. PMID 3955032  0.08
1981 Dennis EA, Darke PL, Deems RA, Kensil CR, Plückthun A. Cobra venom phospholipase A2: a review of its action toward lipid/water interfaces. Molecular and Cellular Biochemistry. 36: 37-45. PMID 7242529  0.64
1979 Adamich M, Roberts MF, Dennis EA. Phospholipid activation of cobra venom phospholipase A2. 2. Characterization of the phospholipid--enzyme interaction. Biochemistry. 18: 3308-14. PMID 465469  1
1979 Roberts MF, Adamich M, Robson RJ, Dennis EA. Phospholipid activation of cobra venom phospholipase A2. 1. Lipid--lipid or lipid--enzyme interaction. Biochemistry. 18: 3301-8. PMID 465468  1
1978 Shaw JO, Roberts MF, Ulevitch RJ, Henson P, Dennis EA. Phospholipase A2 contamination of cobra venom factor preparations. Biologic role in complement-dependent in vivo reactions and inactivation with p-bromophenacyl bromide. The American Journal of Pathology. 91: 517-30. PMID 655262  1
1978 Roberts MF, Otnaess AB, Kensil CA, Dennis EA. The specificity of phospholipase A2 and phospholipase C in a mixed micellar system. The Journal of Biological Chemistry. 253: 1252-7. PMID 624729  1
1978 Roberts MF, Bothner-By AA, Dennis EA. Magnetic nonequivalence within fatty acyl chains of phospholipids in membrane models: 1H nuclear magnetic resonance studies of the alpha-methylene groups. Biochemistry. 17: 935-42. PMID 580222  1
1977 Lewis RV, Roberts MF, Dennis EA, Allison WS. Photoactivated heterobifunctional cross-linking reagents which demonstrate the aggregation state of phospholipase A2. Biochemistry. 16: 5650-4. PMID 921957  1
1977 Roberts MF, Dennis EA. Proton nuclear magnetic resonance demonstration of conformationally nonequivalent phospholipid fatty acid chains in mixed micelles. Journal of the American Chemical Society. 99: 6142-3. PMID 893884  1
1977 Roberts MF, Deems RA, Dennis EA. Dual role of interfacial phospholipid in phospholipase A2 catalysis. Proceedings of the National Academy of Sciences of the United States of America. 74: 1950-4. PMID 266715  1
1977 Roberts MF, Deems RA, Dennis EA. Spectral perturbations of the histidine and tryptophan in cobra venom phospholipase A2 upon metal ion and mixed micelle binding. The Journal of Biological Chemistry. 252: 6011-7. PMID 19461  1
1977 Roberts MF, Deems RA, Mincey TC, Dennis EA. Chemical modification of the histidine residue in phospholipase A2 (Naja naja naja). A case of half-site reactivity. The Journal of Biological Chemistry. 252: 2405-11. PMID 14964  1
1972 Dennis EA, Kennedy EP. Intracellular sites of lipid synthesis and the biogenesis of mitochondria. Journal of Lipid Research. 13: 263-7. PMID 5016308  0.92
1970 Dennis EA, Kennedy EP. Enzymatic synthesis and decarboxylation of phosphatidylserine in Tetrahymena pyriformis. Journal of Lipid Research. 11: 394-403. PMID 5501474  0.92
1969 Kluger R, Covitz F, Dennis E, Williams LD, Westheimer FH. pH-product and pH-rate profiles for the hydrolysis of methyl ethylene phosphate. Rate-limiting pseudorotation Journal of the American Chemical Society. 91: 6066-6072.  1
1967 Kluger R, Kerst F, Lee DG, Dennis EA, Westheimer FH. Hydrolysis of esters of bicycloheptyl- and -heptenylphosphinic acids [17] Journal of the American Chemical Society. 89: 3918-3919.  1
1966 Dennis EA, Westheimer FH. The geometry of the transition state in the hydrolysis of phosphate esters. Journal of the American Chemical Society. 88: 3432-3. PMID 5946603  1
1966 Dennis EA, Westheimer FH. The rates of hydrolysis of esters of cyclic phosphinic acids. Journal of the American Chemical Society. 88: 3431. PMID 5946602  1
1965 Usher DA, Dennis EA, Westheimer FH. Calculation of the bond angles and conformation of methyl ethylene phosphate and related compounds Journal of the American Chemical Society. 87: 2320-2321.  1
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