Matthew Bogyo - Publications

Stanford University, Palo Alto, CA 
Biochemistry, Cell Biology

235 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Onguka O, Babin BM, Lakemeyer M, Foe IT, Amara N, Terrell SM, Lum KM, Cieplak P, Niphakis MJ, Long JZ, Bogyo M. Toxoplasma gondii serine hydrolases regulate parasite lipid mobilization during growth and replication within the host. Cell Chemical Biology. PMID 34043961 DOI: 10.1016/j.chembiol.2021.05.001  0.757
2021 Rompikuntal PK, Kent RS, Foe IT, Deng B, Bogyo M, Ward GE. Blocking Palmitoylation of Toxoplasma gondii Myosin Light Chain 1 Disrupts Glideosome Composition but Has Little Impact on Parasite Motility. Msphere. 6. PMID 34011689 DOI: 10.1128/mSphere.00823-20  0.748
2020 Chen S, Lovell S, Lee S, Fellner M, Mace PD, Bogyo M. Identification of highly selective covalent inhibitors by phage display. Nature Biotechnology. PMID 33199876 DOI: 10.1038/s41587-020-0733-7  0.564
2020 Fellner M, Lentz CS, Jamieson SA, Brewster JL, Chen L, Bogyo M, Mace PD. Structural basis for the inhibitor and substrate specificity of the unique Fph serine hydrolases of Staphylococcus aureus. Acs Infectious Diseases. PMID 32865965 DOI: 10.1021/Acsinfecdis.0C00503  0.415
2020 Telpoukhovskaia MA, Liu K, Sayed FA, Etchegaray JI, Xie M, Zhan L, Li Y, Zhou Y, Le D, Bahr BA, Bogyo M, Ding S, Gan L. Discovery of small molecules that normalize the transcriptome and enhance cysteine cathepsin activity in progranulin-deficient microglia. Scientific Reports. 10: 13688. PMID 32792571 DOI: 10.1038/S41598-020-70534-9  0.346
2020 Faucher F, Bennett JM, Bogyo M, Lovell S. Strategies for Tuning the Selectivity of Chemical Probes that Target Serine Hydrolases. Cell Chemical Biology. PMID 32726586 DOI: 10.1016/J.Chembiol.2020.07.008  0.453
2020 Tholen M, Yim JJ, Groborz K, Yoo E, Martin BA, van den Berg NS, Drag M, Bogyo M. Design of optical imaging probes by screening of diverse substrate libraries directly in disease tissue extracts. Angewandte Chemie (International Ed. in English). PMID 32589815 DOI: 10.1002/Anie.202006719  0.375
2020 Widen JC, Tholen M, Yim JJ, Bogyo M. Methods for analysis of near-infrared (NIR) quenched-fluorescent contrast agents in mouse models of cancer. Methods in Enzymology. 639: 141-166. PMID 32475399 DOI: 10.1016/Bs.Mie.2020.04.012  0.306
2020 Keller LJ, Lentz CS, Chen YE, Metivier RJ, Weerapana E, Fischbach M, Bogyo M. Characterization of serine hydrolases across clinical isolates of commensal skin bacteria Staphylococcus epidermidis using activity-based protein profiling. Acs Infectious Diseases. PMID 32298574 DOI: 10.1021/Acsinfecdis.0C00095  0.339
2020 Yoo E, Schulze CJ, Stokes BH, Onguka O, Yeo T, Mok S, Gnädig NF, Zhou Y, Kurita K, Foe IT, Terrell SM, Boucher MJ, Cieplak P, Kumpornsin K, Lee MCS, ... ... Bogyo M, et al. The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites. Cell Chemical Biology. PMID 31978322 DOI: 10.1016/J.Chembiol.2020.01.001  0.78
2019 Sanchez MI, de Vries LE, Lehmann C, Lee JT, Ang KK, Wilson C, Chen S, Arkin MR, Bogyo M, Deu E. Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening. Plos One. 14: e0226270. PMID 31851699 DOI: 10.1371/Journal.Pone.0226270  0.434
2019 Keller LJ, Babin BM, Lakemeyer M, Bogyo M. Activity-based protein profiling in bacteria: Applications for identification of therapeutic targets and characterization of microbial communities. Current Opinion in Chemical Biology. 54: 45-53. PMID 31835131 DOI: 10.1016/J.Cbpa.2019.10.007  0.437
2019 Chen S, Yim JJ, Bogyo M. Synthetic and biological approaches to map substrate specificities of proteases. Biological Chemistry. PMID 31639098 DOI: 10.1515/Hsz-2019-0332  0.64
2019 Babin BM, Kasperkiewicz P, Janiszewski T, Yoo E, Drag M, Bogyo M. Leveraging peptide substrate libraries to design inhibitors of bacterial Lon protease. Acs Chemical Biology. PMID 31464417 DOI: 10.1021/Acschembio.9B00529  0.404
2019 Szumska J, Batool Z, Al-Hashimi A, Venugopalan V, Skripnik V, Schaschke N, Bogyo M, Brix K. Treatment of rat thyrocytes in vitro with cathepsin B and L inhibitors results in disruption of primary cilia leading to redistribution of the trace amine associated receptor 1 to the endoplasmic reticulum. Biochimie. PMID 31302164 DOI: 10.1016/J.Biochi.2019.07.010  0.339
2019 Veillard F, Sztukowska M, Nowakowska Z, Mizgalska D, Thøgersen IB, Enghild JJ, Bogyo M, Potempa B, Nguyen KA, Potempa J. Proteolytic processing and activation of gingipain zymogens secreted by T9SS of Porphyromonas gingivalis. Biochimie. PMID 31212040 DOI: 10.1016/J.Biochi.2019.06.010  0.354
2019 de Vries LE, Sanchez MI, Groborz K, Kuppens L, Poreba M, Lehmann C, Nevins N, Withers-Martinez C, Hirst DJ, Yuan F, Arastu-Kapur S, Horn M, Mares M, Bogyo M, Drag M, et al. Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity identifies differences in amino acid preferences between peptide-based substrates and covalent inhibitors. The Febs Journal. PMID 31177613 DOI: 10.1111/Febs.14953  0.442
2019 Stokes BH, Yoo E, Murithi JM, Luth MR, Afanasyev P, da Fonseca PCA, Winzeler EA, Ng CL, Bogyo M, Fidock DA. Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents. Plos Pathogens. 15: e1007722. PMID 31170268 DOI: 10.1371/Journal.Ppat.1007722  0.362
2019 Chen L, Keller LJ, Cordasco EA, Bogyo M, Lentz CS. Single-cell phenotypic characterization of Staphylococcus aureus with fluorescent triazole urea activity-based probes. Angewandte Chemie (International Ed. in English). PMID 30768830 DOI: 10.1002/Anie.201900511  0.427
2018 Foe IT, Onguka O, Amberg-Johnson K, Garner RM, Amara N, Beatty W, Yeh E, Bogyo M. Erratum for Foe et al., "The Toxoplasma gondii Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture". Msphere. 3. PMID 31329810 DOI: 10.1128/mSphere.00535-18  0.734
2018 Garland M, Babin BM, Miyashita SI, Loscher S, Shen Y, Dong M, Bogyo M. Covalent modifiers of Botulinum neurotoxin counteract toxin persistence. Acs Chemical Biology. PMID 30571080 DOI: 10.1021/Acschembio.8B00937  0.408
2018 Amara N, Foe IT, Onguka O, Garland M, Bogyo M. Synthetic Fluorogenic Peptides Reveal Dynamic Substrate Specificity of Depalmitoylases. Cell Chemical Biology. PMID 30393067 DOI: 10.1016/J.Chembiol.2018.10.005  0.779
2018 Shrivastav M, Gounaris E, Khan MW, Ko J, Ryu SH, Bogyo M, Larson A, Barret TA, Bentrem DJ. Validation of near infrared fluorescence (NIRF) probes in vivo with dual laser NIRF endoscope. Plos One. 13: e0206568. PMID 30388158 DOI: 10.1371/Journal.Pone.0206568  0.313
2018 Seth-Pasricha M, Senn S, Sanman LE, Bogyo M, Nanda V, Bidle KA, Bidle KD. Catalytic linkage between caspase activity and proteostasis in Archaea. Environmental Microbiology. PMID 30370585 DOI: 10.1111/1462-2920.14456  0.455
2018 Foe IT, Onguka O, Amberg-Johnson K, Garner RM, Amara N, Beatty W, Yeh E, Bogyo M. The Active Serine Hydrolase 4 Regulates Parasite Division and Intravacuolar Parasite Architecture. Msphere. 3. PMID 30232166 DOI: 10.1128/mSphere.00393-18  0.768
2018 Amara N, Tholen M, Bogyo M. Chemical Tools for Selective Activity Profiling of Endogenously Expressed MMP-14 in Multicellular Models. Acs Chemical Biology. PMID 30160940 DOI: 10.1021/Acschembio.8B00562  0.341
2018 Yoo E, Stokes BH, de Jong H, Vanaerschot M, Kumar T, Lawrence N, Njoroge M, Garcia A, van der Westhuyzen R, Momper JD, Ng CL, Fidock DA, Bogyo M. Defining the determinants of specificity of Plasmodium proteasome inhibitors. Journal of the American Chemical Society. PMID 30107725 DOI: 10.1021/Jacs.8B06656  0.45
2018 Lentz CS, Sheldon JR, Crawford LA, Cooper R, Garland M, Amieva MR, Weerapana E, Skaar EP, Bogyo M. Identification of a S. aureus virulence factor by activity-based protein profiling (ABPP). Nature Chemical Biology. PMID 29769740 DOI: 10.1038/S41589-018-0060-1  0.425
2018 Hewings DS, Heideker J, Ma TP, AhYoung AP, El Oualid F, Amore A, Costakes GT, Kirchhofer D, Brasher B, Pillow T, Popovych N, Maurer T, Schwerdtfeger C, Forrest WF, Yu K, ... ... Bogyo M, et al. Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes. Nature Communications. 9: 1162. PMID 29563501 DOI: 10.1038/S41467-018-03511-6  0.406
2018 Flanagan-Steet H, Christian C, Lu PN, Aarnio-Peterson M, Sanman L, Archer-Hartmann S, Azadi P, Bogyo M, Steet RA. TGF-ß Regulates Cathepsin Activation during Normal and Pathogenic Development. Cell Reports. 22: 2964-2977. PMID 29539424 DOI: 10.1016/J.Celrep.2018.02.066  0.383
2018 Garland M, Schulze CJ, Foe IT, van der Linden WA, Child MA, Bogyo M. Development of an activity-based probe for acyl-protein thioesterases. Plos One. 13: e0190255. PMID 29364904 DOI: 10.1371/Journal.Pone.0190255  0.793
2018 Garland M, Jaworek-Korjakowska J, Libal U, Bogyo M, Sieńczyk M. An Automatic Analysis System for High-Throughput Clostridium Difficile Toxin Activity Screening Applied Sciences. 8: 1512. DOI: 10.3390/App8091512  0.316
2017 Tomlin FM, Gerling-Driessen UIM, Liu YC, Flynn RA, Vangala JR, Lentz CS, Clauder-Muenster S, Jakob P, Mueller WF, Ordoñez-Rueda D, Paulsen M, Matsui N, Foley D, Rafalko A, Suzuki T, ... Bogyo M, et al. Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity. Acs Central Science. 3: 1143-1155. PMID 29202016 DOI: 10.1021/Acscentsci.7B00224  0.414
2017 Aillaud C, Bosc C, Peris L, Bosson A, Heemeryck P, Van Dijk J, Le Friec J, Boulan B, Vossier F, Sanman LE, Syed S, Amara N, Couté Y, Lafanechère L, Denarier E, ... ... Bogyo M, et al. Vasohibins/SVBP are tubulin carboxypeptidases (TCP) that regulate neuron differentiation. Science (New York, N.Y.). PMID 29146868 DOI: 10.1126/Science.Aao4165  0.323
2017 Hopp CS, Bennett BL, Mishra S, Lehmann C, Hanson KK, Lin JW, Rousseau K, Carvalho FA, van der Linden WA, Santos NC, Bogyo M, Khan SM, Heussler V, Sinnis P. Deletion of the rodent malaria ortholog for falcipain-1 highlights differences between hepatic and blood stage merozoites. Plos Pathogens. 13: e1006586. PMID 28922424 DOI: 10.1371/Journal.Ppat.1006586  0.344
2017 Ng CL, Fidock DA, Bogyo M. Protein Degradation Systems as Antimalarial Therapeutic Targets. Trends in Parasitology. PMID 28688800 DOI: 10.1016/J.Pt.2017.05.009  0.397
2017 Di Cristina M, Dou Z, Lunghi M, Kannan G, Huynh MH, McGovern OL, Schultz TL, Schultz AJ, Miller AJ, Hayes BM, van der Linden W, Emiliani C, Bogyo M, Besteiro S, Coppens I, et al. Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection. Nature Microbiology. 2: 17096. PMID 28628099 DOI: 10.1038/Nmicrobiol.2017.96  0.326
2017 Child MA, Garland M, Foe I, Madzelan P, Treeck M, van der Linden WA, Oresic Bender K, Weerapana E, Wilson MA, Boothroyd JC, Reese ML, Bogyo M. Toxoplasma DJ-1 Regulates Organelle Secretion by a Direct Interaction with Calcium-Dependent Protein Kinase 1. Mbio. 8. PMID 28246362 DOI: 10.1128/Mbio.02189-16  0.775
2017 Hewings DS, Flygare JA, Bogyo M, Wertz IE. Activity-based probes for the ubiquitin conjugation-deconjugation machinery: new chemistries, new tools, and new insights. The Febs Journal. PMID 28196299 DOI: 10.1111/Febs.14039  0.445
2017 Hewings DS, Flygare JA, Wertz IE, Bogyo M. Activity-based probes for the multicatalytic proteasome. The Febs Journal. PMID 28107776 DOI: 10.1111/Febs.14016  0.464
2017 Edgington-Mitchell LE, Bogyo M, Verdoes M. Live Cell Imaging and Profiling of Cysteine Cathepsin Activity Using a Quenched Activity-Based Probe. Methods in Molecular Biology (Clifton, N.J.). 1491: 145-159. PMID 27778287 DOI: 10.1007/978-1-4939-6439-0_11  0.392
2017 Bogyo M. New chemical probe technologies: applications to imaging and drug discovery (Conference Presentation) Proceedings of Spie. 10049. DOI: 10.1117/12.2257636  0.375
2016 Dubey R, Staker BL, Foe IT, Bogyo M, Myler PJ, Ngô HM, Gubbels MJ. Membrane skeletal association and post-translational allosteric regulation of Toxoplasma gondii GAPDH1. Molecular Microbiology. PMID 27859784 DOI: 10.1111/Mmi.13577  0.773
2016 Lentz CS, Ordonez AA, Kasperkiewicz P, La Greca F, O'Donoghue AJ, Schulze CJ, Powers JC, Craik CS, Drag M, Jain SK, Bogyo M. Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 27739665 DOI: 10.1021/Acsinfecdis.6B00092  0.432
2016 Grüner BM, Schulze CJ, Yang D, Ogasawara D, Dix MM, Rogers ZN, Chuang CH, McFarland CD, Chiou SH, Brown JM, Cravatt BF, Bogyo M, Winslow MM. An in vivo multiplexed small-molecule screening platform. Nature Methods. PMID 27617390 DOI: 10.1038/Nmeth.3992  0.353
2016 Abd-Elrahman I, Kosuge H, Wises Sadan T, Ben-Nun Y, Meir K, Rubinstein C, Bogyo M, McConnell MV, Blum G. Cathepsin Activity-Based Probes and Inhibitor for Preclinical Atherosclerosis Imaging and Macrophage Depletion. Plos One. 11: e0160522. PMID 27532109 DOI: 10.1371/Journal.Pone.0160522  0.305
2016 Edgington-Mitchell LE, Wartmann T, Fleming AK, Gocheva V, van der Linden WA, Withana NP, Verdoes M, Aurelio L, Edgington-Mitchell D, Lieu T, Parker BS, Graham B, Reinheckel T, Furness JB, Joyce JA, ... ... Bogyo M, et al. Legumain is Activated in Macrophages during Pancreatitis. American Journal of Physiology. Gastrointestinal and Liver Physiology. ajpgi.00047.2016. PMID 27514475 DOI: 10.1152/Ajpgi.00047.2016  0.325
2016 Sanman LE, van der Linden WA, Verdoes M, Bogyo M. Bifunctional Probes of Cathepsin Protease Activity and pH Reveal Alterations in Endolysosomal pH during Bacterial Infection. Cell Chemical Biology. PMID 27427229 DOI: 10.1016/J.Chembiol.2016.05.019  0.324
2016 van der Linden WA, Schulze CJ, Herbert AS, Krause TB, Wirchnianski AA, Dye JM, Chandran K, Bogyo M. Cysteine Cathepsin Inhibitors as Anti-Ebola Agents. Acs Infectious Diseases. 2: 173-179. PMID 27347558 DOI: 10.1021/Acsinfecdis.5B00130  0.372
2016 Li H, Bogyo M, da Fonseca PC. The cryo-EM structure of the Plasmodium falciparum 20S proteasome and its use in the fight against malaria. The Febs Journal. PMID 27286897 DOI: 10.1111/Febs.13780  0.417
2016 Withana NP, Saito T, Ma X, Garland M, Liu C, Kosuge H, Amsallem M, Verdoes M, Ofori LO, Fischbein M, Arakawa M, Cheng Z, McConnell MV, Bogyo M. Dual Modality Activity Based Probes as Molecular Imaging Agents for Vascular Inflammation. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 27199363 DOI: 10.2967/Jnumed.115.171553  0.342
2016 Edgington-Mitchell LE, Bogyo M. Detection of Active Caspases During Apoptosis Using Fluorescent Activity-Based Probes. Methods in Molecular Biology (Clifton, N.J.). 1419: 27-39. PMID 27108429 DOI: 10.1007/978-1-4939-3581-9_3  0.388
2016 Sanman LE, Qian Y, Eisele NA, Ng TM, van der Linden WA, Monack DM, Weerapana E, Bogyo M. Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death. Elife. 5. PMID 27011353 DOI: 10.7554/Elife.13663  0.308
2016 Li H, O'Donoghue AJ, van der Linden WA, Xie SC, Yoo E, Foe IT, Tilley L, Craik CS, da Fonseca PC, Bogyo M. Structure- and function-based design of Plasmodium-selective proteasome inhibitors. Nature. 530: 233-6. PMID 26863983 DOI: 10.1038/Nature16936  0.798
2016 Withana NP, Ma X, McGuire HM, Verdoes M, van der Linden WA, Ofori LO, Zhang R, Li H, Sanman LE, Wei K, Yao S, Wu P, Li F, Huang H, Xu Z, ... ... Bogyo M, et al. Non-invasive Imaging of Idiopathic Pulmonary Fibrosis Using Cathepsin Protease Probes. Scientific Reports. 6: 19755. PMID 26797565 DOI: 10.1038/Srep19755  0.312
2016 Withana NP, Garland M, Verdoes M, Ofori LO, Segal E, Bogyo M. Labeling of active proteases in fresh-frozen tissues by topical application of quenched activity-based probes. Nature Protocols. 11: 184-91. PMID 26716706 DOI: 10.1038/Nprot.2016.004  0.381
2015 Lauterwasser EM, Fontaine SD, Li H, Gut J, Katneni K, Charman SA, Rosenthal PJ, Bogyo M, Renslo AR. Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria. Acs Medicinal Chemistry Letters. 6: 1145-1149. PMID 26617969 DOI: 10.1021/Acsmedchemlett.5B00296  0.315
2015 Foe IT, Child MA, Majmudar JD, Krishnamurthy S, van der Linden WA, Ward GE, Martin BR, Bogyo M. Global Analysis of Palmitoylated Proteins in Toxoplasma gondii. Cell Host & Microbe. 18: 501-11. PMID 26468752 DOI: 10.1016/J.Chom.2015.09.006  0.776
2015 Bender KO, Garland M, Ferreyra JA, Hryckowian AJ, Child MA, Puri AW, Solow-Cordero DE, Higginbottom SK, Segal E, Banaei N, Shen A, Sonnenburg JL, Bogyo M. A small-molecule antivirulence agent for treating Clostridium difficile infection. Science Translational Medicine. 7: 306ra148. PMID 26400909 DOI: 10.1126/Scitranslmed.Aac9103  0.37
2015 Staniec D, Ksiazek M, Thøgersen IB, Enghild JJ, Sroka A, Bryzek D, Bogyo M, Abrahamson M, Potempa J. Calcium Regulates the Activity and Structural Stability of Tpr, a Bacterial Calpain-like Peptidase. The Journal of Biological Chemistry. 290: 27248-60. PMID 26385924 DOI: 10.1074/Jbc.M115.648782  0.371
2015 Hou L, Cooley J, Swanson R, Ong PC, Pike RN, Bogyo M, Olson ST, Remold-O'Donnell E. The protease cathepsin L regulates Th17 cell differentiation. Journal of Autoimmunity. PMID 26343333 DOI: 10.1016/J.Jaut.2015.08.006  0.321
2015 Edgington-Mitchell LE, Rautela J, Duivenvoorden HM, Jayatilleke KM, van der Linden WA, Verdoes M, Bogyo M, Parker BS. Cysteine cathepsin activity suppresses osteoclastogenesis of myeloid-derived suppressor cells in breast cancer. Oncotarget. 6: 27008-22. PMID 26308073 DOI: 10.18632/Oncotarget.4714  0.39
2015 van der Linden WA, Segal E, Child MA, Byzia A, Drąg M, Bogyo M. Design and Synthesis of Activity-Based Probes and Inhibitors for Bleomycin Hydrolase. Chemistry & Biology. 22: 995-1001. PMID 26256478 DOI: 10.1016/J.Chembiol.2015.07.010  0.453
2015 Lu H, Chandrasekar B, Oeljeklaus J, Misas-Villamil JC, Wang Z, Shindo T, Bogyo M, Kaiser M, van der Hoorn RA. Subfamily-specific Fluorescent Probes for Cys proteases Display Dynamic Protease Activities During Seed Germination. Plant Physiology. PMID 26048883 DOI: 10.1104/Pp.114.254466  0.432
2015 Ofori LO, Withana NP, Prestwood TR, Verdoes M, Brady JJ, Winslow MM, Sorger J, Bogyo M. Design of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery. Acs Chemical Biology. 10: 1977-88. PMID 26039341 DOI: 10.1021/Acschembio.5B00205  0.335
2015 Gangoda L, Keerthikumar S, Fonseka P, Edgington LE, Ang CS, Ozcitti C, Bogyo M, Parker BS, Mathivanan S. Inhibition of cathepsin proteases attenuates migration and sensitizes aggressive N-Myc amplified human neuroblastoma cells to doxorubicin. Oncotarget. 6: 11175-90. PMID 25883214 DOI: 10.18632/Oncotarget.3579  0.305
2015 Oresic Bender K, Ofori L, van der Linden WA, Mock ED, Datta GK, Chowdhury S, Li H, Segal E, Sanchez Lopez M, Ellman JA, Figdor CG, Bogyo M, Verdoes M. Design of a highly selective quenched activity-based probe and its application in dual color imaging studies of cathepsin S activity localization. Journal of the American Chemical Society. 137: 4771-7. PMID 25785540 DOI: 10.1021/Jacs.5B00315  0.431
2015 Segal E, Prestwood TR, van der Linden WA, Carmi Y, Bhattacharya N, Withana N, Verdoes M, Habtezion A, Engleman EG, Bogyo M. Detection of intestinal cancer by local, topical application of a quenched fluorescence probe for cysteine cathepsins. Chemistry & Biology. 22: 148-58. PMID 25579207 DOI: 10.1016/J.Chembiol.2014.11.008  0.307
2015 Hachmann J, Edgington-Mitchell LE, Poreba M, Sanman LE, Drag M, Bogyo M, Salvesen GS. Probes to monitor activity of the paracaspase MALT1. Chemistry & Biology. 22: 139-47. PMID 25556944 DOI: 10.1016/J.Chembiol.2014.11.011  0.41
2014 Li H, Tsu C, Blackburn C, Li G, Hales P, Dick L, Bogyo M. Identification of potent and selective non-covalent inhibitors of the Plasmodium falciparum proteasome. Journal of the American Chemical Society. 136: 13562-5. PMID 25226494 DOI: 10.1021/Ja507692Y  0.392
2014 Godinat A, Budin G, Morales AR, Park HM, Sanman LE, Bogyo M, Yu A, Stahl A, Dubikovskaya EA. A biocompatible "split luciferin" reaction and its application for non-invasive bioluminescent imaging of protease activity in living animals. Current Protocols in Chemical Biology. 6: 169-89. PMID 25205565 DOI: 10.1002/9780470559277.Ch140047  0.354
2014 Gangoda L, Doerflinger M, Srivastava R, Narayan N, Edgington LE, Orian J, Hawkins C, O'Reilly LA, Gu H, Bogyo M, Ekert P, Strasser A, Puthalakath H. Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice. Cell Death and Differentiation. 21: 1815-24. PMID 25012505 DOI: 10.1038/Cdd.2014.98  0.307
2014 Li H, van der Linden WA, Verdoes M, Florea BI, McAllister FE, Govindaswamy K, Elias JE, Bhanot P, Overkleeft HS, Bogyo M. Assessing subunit dependency of the Plasmodium proteasome using small molecule inhibitors and active site probes. Acs Chemical Biology. 9: 1869-76. PMID 24918547 DOI: 10.1021/Cb5001263  0.575
2014 Sanman LE, Bogyo M. Activity-based profiling of proteases. Annual Review of Biochemistry. 83: 249-73. PMID 24905783 DOI: 10.1146/Annurev-Biochem-060713-035352  0.436
2014 Haedke UR, Frommel SC, Hansen F, Hahne H, Kuster B, Bogyo M, Verhelst SHL. Phosphoramidates as novel activity-based probes for serine proteases Chembiochem. 15: 1106-1110. PMID 24817682 DOI: 10.1002/Cbic.201400013  0.42
2014 Cattaruzza F, Amadesi S, Carlsson JF, Murphy JE, Lyo V, Kirkwood K, Cottrell GS, Bogyo M, Knecht W, Bunnett NW. Serine proteases and protease-activated receptor 2 mediate the proinflammatory and algesic actions of diverse stimulants. British Journal of Pharmacology. 171: 3814-26. PMID 24749982 DOI: 10.1111/Bph.12738  0.375
2014 Walker E, Gopalakrishnan R, Bogyo M, Basilion JP. Microscopic detection of quenched activity-based optical imaging probes using an antibody detection system: localizing protease activity. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 16: 608-18. PMID 24705781 DOI: 10.1007/S11307-014-0736-1  0.356
2013 Rothberg JM, Bailey KM, Wojtkowiak JW, Ben-Nun Y, Bogyo M, Weber E, Moin K, Blum G, Mattingly RR, Gillies RJ, Sloane BF. Acid-mediated tumor proteolysis: contribution of cysteine cathepsins. Neoplasia (New York, N.Y.). 15: 1125-37. PMID 24204192 DOI: 10.1593/Neo.13946  0.323
2013 Deu E, Chen IT, Lauterwasser EM, Valderramos J, Li H, Edgington LE, Renslo AR, Bogyo M. Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivo. Proceedings of the National Academy of Sciences of the United States of America. 110: 18244-9. PMID 24145449 DOI: 10.1073/Pnas.1312782110  0.338
2013 Verdoes M, Oresic Bender K, Segal E, Van Der Linden WA, Syed S, Withana NP, Sanman LE, Bogyo M. Improved quenched fluorescent probe for imaging of cysteine cathepsin activity Journal of the American Chemical Society. 135: 14726-14730. PMID 23971698 DOI: 10.1021/Ja4056068  0.352
2013 Puri AW, Bogyo M. Applications of small molecule probes in dissecting mechanisms of bacterial virulence and host responses. Biochemistry. 52: 5985-96. PMID 23937332 DOI: 10.1021/Bi400854D  0.406
2013 Child MA, Hall CI, Beck JR, Ofori LO, Albrow VE, Garland M, Bowyer PW, Bradley PJ, Powers JC, Boothroyd JC, Weerapana E, Bogyo M. Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion. Nature Chemical Biology. 9: 651-6. PMID 23934245 DOI: 10.1038/Nchembio.1315  0.758
2013 Tanaka TQ, Deu E, Molina-Cruz A, Ashburne MJ, Ali O, Suri A, Kortagere S, Bogyo M, Williamson KC. Plasmodium dipeptidyl aminopeptidases as malaria transmission-blocking drug targets. Antimicrobial Agents and Chemotherapy. 57: 4645-52. PMID 23836185 DOI: 10.1128/Aac.02495-12  0.361
2013 Gloeckl S, Ong VA, Patel P, Tyndall JD, Timms P, Beagley KW, Allan JA, Armitage CW, Turnbull L, Whitchurch CB, Merdanovic M, Ehrmann M, Powers JC, Oleksyszyn J, Verdoes M, ... Bogyo M, et al. Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis. Molecular Microbiology. 89: 676-89. PMID 23796320 DOI: 10.1111/Mmi.12306  0.375
2013 Edgington LE, Bogyo M. In vivo imaging and biochemical characterization of protease function using fluorescent activity-based probes. Current Protocols in Chemical Biology. 5: 25-44. PMID 23788323 DOI: 10.1002/9780470559277.Ch120235  0.389
2013 Xiao J, Broz P, Puri AW, Deu E, Morell M, Monack DM, Bogyo M. A coupled protein and probe engineering approach for selective inhibition and activity-based probe labeling of the caspases. Journal of the American Chemical Society. 135: 9130-8. PMID 23701470 DOI: 10.1021/Ja403521U  0.447
2013 Morell M, Nguyen Duc T, Willis AL, Syed S, Lee J, Deu E, Deng Y, Xiao J, Turk BE, Jessen JR, Weiss SJ, Bogyo M. Coupling protein engineering with probe design to inhibit and image matrix metalloproteinases with controlled specificity. Journal of the American Chemical Society. 135: 9139-48. PMID 23701445 DOI: 10.1021/Ja403523P  0.366
2013 Godinat A, Park HM, Miller SC, Cheng K, Hanahan D, Sanman LE, Bogyo M, Yu A, Nikitin GF, Stahl A, Dubikovskaya EA. A biocompatible in vivo ligation reaction and its application for noninvasive bioluminescent imaging of protease activity in living mice. Acs Chemical Biology. 8: 987-99. PMID 23463944 DOI: 10.1021/Cb3007314  0.342
2013 Lu H, Wang Z, Shabab M, Oeljeklaus J, Verhelst SH, Kaschani F, Kaiser M, Bogyo M, van der Hoorn RA. A substrate-inspired probe monitors translocation, activation, and subcellular targeting of bacterial type III effector protease AvrPphB. Chemistry & Biology. 20: 168-76. PMID 23438746 DOI: 10.1016/J.Chembiol.2012.11.007  0.412
2013 Lee J, Bogyo M. Target deconvolution techniques in modern phenotypic profiling. Current Opinion in Chemical Biology. 17: 118-26. PMID 23337810 DOI: 10.1016/J.Cbpa.2012.12.022  0.34
2013 Edgington LE, Verdoes M, Ortega A, Withana NP, Lee J, Syed S, Bachmann MH, Blum G, Bogyo M. Functional imaging of legumain in cancer using a new quenched activity-based probe. Journal of the American Chemical Society. 135: 174-82. PMID 23215039 DOI: 10.1021/Ja307083B  0.361
2013 Misas-Villamil JC, Toenges G, Kolodziejek I, Sadaghiani AM, Kaschani F, Colby T, Bogyo M, van der Hoorn RA. Activity profiling of vacuolar processing enzymes reveals a role for VPE during oomycete infection. The Plant Journal : For Cell and Molecular Biology. 73: 689-700. PMID 23134548 DOI: 10.1111/Tpj.12062  0.42
2012 Stolze SC, Deu E, Kaschani F, Li N, Florea BI, Richau KH, Colby T, van der Hoorn RA, Overkleeft HS, Bogyo M, Kaiser M. The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains. Chemistry & Biology. 19: 1546-55. PMID 23261598 DOI: 10.1016/J.Chembiol.2012.09.020  0.541
2012 Li H, Ponder EL, Verdoes M, Asbjornsdottir KH, Deu E, Edgington LE, Lee JT, Kirk CJ, Demo SD, Williamson KC, Bogyo M. Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicity. Chemistry & Biology. 19: 1535-45. PMID 23142757 DOI: 10.1016/J.Chembiol.2012.09.019  0.797
2012 Lyo V, Cattaruzza F, Kim TN, Walker AW, Paulick M, Cox D, Cloyd J, Buxbaum J, Ostroff J, Bogyo M, Grady EF, Bunnett NW, Kirkwood KS. Active cathepsins B, L, and S in murine and human pancreatitis. American Journal of Physiology. Gastrointestinal and Liver Physiology. 303: G894-903. PMID 22899821 DOI: 10.1152/Ajpgi.00073.2012  0.312
2012 Goussetis DJ, Gounaris E, Wu EJ, Vakana E, Sharma B, Bogyo M, Altman JK, Platanias LC. Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide. Blood. 120: 3555-62. PMID 22898604 DOI: 10.1182/Blood-2012-01-402578  0.338
2012 Puri AW, Broz P, Shen A, Monack DM, Bogyo M. Caspase-1 activity is required to bypass macrophage apoptosis upon Salmonella infection. Nature Chemical Biology. 8: 745-7. PMID 22797665 DOI: 10.1038/Nchembio.1023  0.331
2012 Verdoes M, Edgington LE, Scheeren FA, Leyva M, Blum G, Weiskopf K, Bachmann MH, Ellman JA, Bogyo M. A nonpeptidic cathepsin S activity-based probe for noninvasive optical imaging of tumor-associated macrophages. Chemistry & Biology. 19: 619-28. PMID 22633413 DOI: 10.1016/J.Chembiol.2012.03.012  0.307
2012 Edgington LE, van Raam BJ, Verdoes M, Wierschem C, Salvesen GS, Bogyo M. An optimized activity-based probe for the study of caspase-6 activation. Chemistry & Biology. 19: 340-52. PMID 22444589 DOI: 10.1016/J.Chembiol.2011.12.021  0.38
2012 Richau KH, Kaschani F, Verdoes M, Pansuriya TC, Niessen S, Stüber K, Colby T, Overkleeft HS, Bogyo M, Van der Hoorn RA. Subclassification and biochemical analysis of plant papain-like cysteine proteases displays subfamily-specific characteristics. Plant Physiology. 158: 1583-99. PMID 22371507 DOI: 10.1104/Pp.112.194001  0.558
2012 Fritz HM, Bowyer PW, Bogyo M, Conrad PA, Boothroyd JC. Proteomic analysis of fractionated Toxoplasma oocysts reveals clues to their environmental resistance. Plos One. 7: e29955. PMID 22279555 DOI: 10.1371/Journal.Pone.0029955  0.343
2012 Ferreira KS, Kreutz C, Macnelly S, Neubert K, Haber A, Bogyo M, Timmer J, Borner C. Caspase-3 feeds back on caspase-8, Bid and XIAP in type I Fas signaling in primary mouse hepatocytes. Apoptosis : An International Journal On Programmed Cell Death. 17: 503-15. PMID 22246639 DOI: 10.1007/S10495-011-0691-0  0.34
2012 Lee J, Bogyo M. Synthesis and evaluation of aza-peptidyl inhibitors of the lysosomal asparaginyl endopeptidase, legumain. Bioorganic & Medicinal Chemistry Letters. 22: 1340-3. PMID 22243962 DOI: 10.1016/J.Bmcl.2011.12.079  0.42
2012 Deu E, Verdoes M, Bogyo M. New approaches for dissecting protease functions to improve probe development and drug discovery. Nature Structural & Molecular Biology. 19: 9-16. PMID 22218294 DOI: 10.1038/Nsmb.2203  0.4
2012 Kalińska M, Kantyka T, Greenbaum DC, Larsen KS, Władyka B, Jabaiah A, Bogyo M, Daugherty PS, Wysocka M, Jaros M, Lesner A, Rolka K, Schaschke N, Stennicke H, Dubin A, et al. Substrate specificity of Staphylococcus aureus cysteine proteases--Staphopains A, B and C. Biochimie. 94: 318-27. PMID 21802486 DOI: 10.1016/J.Biochi.2011.07.020  0.34
2012 Li H, Child MA, Bogyo M. Proteases as regulators of pathogenesis: examples from the Apicomplexa. Biochimica Et Biophysica Acta. 1824: 177-85. PMID 21683169 DOI: 10.1016/J.Bbapap.2011.06.002  0.41
2012 Goussetis D, Gounaris E, Wu EJ, Vakana E, Sharma B, Altman JK, Platanais LC, Bogyo M. Abstract LB-81: Autophagic degradation of BCR/ABL by arsenic trioxide and the role of cysteine cathepsins Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-81  0.333
2011 Ren G, Blum G, Verdoes M, Liu H, Syed S, Edgington LE, Gheysens O, Miao Z, Jiang H, Gambhir SS, Bogyo M, Cheng Z. Non-invasive imaging of cysteine cathepsin activity in solid tumors using a 64Cu-labeled activity-based probe. Plos One. 6: e28029. PMID 22132198 DOI: 10.1371/Journal.Pone.0028029  0.39
2011 Edgington LE, Verdoes M, Bogyo M. Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes. Current Opinion in Chemical Biology. 15: 798-805. PMID 22098719 DOI: 10.1016/J.Cbpa.2011.10.012  0.472
2011 Cattaruzza F, Lyo V, Jones E, Pham D, Hawkins J, Kirkwood K, Valdez-Morales E, Ibeakanma C, Vanner SJ, Bogyo M, Bunnett NW. Cathepsin S is activated during colitis and causes visceral hyperalgesia by a PAR2-dependent mechanism in mice. Gastroenterology. 141: 1864-74.e1-3. PMID 21802389 DOI: 10.1053/J.Gastro.2011.07.035  0.337
2011 Albrow VE, Ponder EL, Fasci D, Békés M, Deu E, Salvesen GS, Bogyo M. Development of small molecule inhibitors and probes of human SUMO deconjugating proteases. Chemistry & Biology. 18: 722-32. PMID 21700208 DOI: 10.1016/J.Chembiol.2011.05.008  0.806
2011 Ponder EL, Albrow VE, Leader BA, Békés M, Mikolajczyk J, Fonović UP, Shen A, Drag M, Xiao J, Deu E, Campbell AJ, Powers JC, Salvesen GS, Bogyo M. Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors. Chemistry & Biology. 18: 711-21. PMID 21700207 DOI: 10.1016/J.Chembiol.2011.04.010  0.808
2011 Hall CI, Reese ML, Weerapana E, Child MA, Bowyer PW, Albrow VE, Haraldsen JD, Phillips MR, Sandoval ED, Ward GE, Cravatt BF, Boothroyd JC, Bogyo M. Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion. Proceedings of the National Academy of Sciences of the United States of America. 108: 10568-73. PMID 21670272 DOI: 10.1073/Pnas.1105622108  0.763
2011 Mahajan SS, Deu E, Lauterwasser EM, Leyva MJ, Ellman JA, Bogyo M, Renslo AR. A fragmenting hybrid approach for targeted delivery of multiple therapeutic agents to the malaria parasite. Chemmedchem. 6: 415-9. PMID 21360816 DOI: 10.1002/Cmdc.201100002  0.316
2011 Paulick MG, Bogyo M. Development of activity-based probes for cathepsin X. Acs Chemical Biology. 6: 563-72. PMID 21322635 DOI: 10.1021/Cb100392R  0.327
2011 Shen A, Lupardus PJ, Gersch MM, Puri AW, Albrow VE, Garcia KC, Bogyo M. Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins. Nature Structural & Molecular Biology. 18: 364-71. PMID 21317893 DOI: 10.1038/Nsmb.1990  0.382
2011 Amino R, Bassat Q, Baum J, Billker O, Bogyo M, Bousema T, Christophides G, Deitsch K, Dinglasan R, Djimde A, Duraisingh M, Dzinjalamala F, Happi C, Heussler V, Kramarik J, et al. A research agenda for malaria eradication: basic science and enabling technologies Plos Medicine. 8: 1-6. PMID 21311584 DOI: 10.1371/Journal.Pmed.1000399  0.321
2011 Bowyer PW, Simon GM, Cravatt BF, Bogyo M. Global profiling of proteolysis during rupture of Plasmodium falciparum from the host erythrocyte. Molecular & Cellular Proteomics : McP. 10: M110.001636. PMID 20943600 DOI: 10.1074/Mcp.M110.001636  0.406
2011 Wang F, Krai P, Deu E, Bibb B, Lauritzen C, Pedersen J, Bogyo M, Klemba M. Biochemical characterization of Plasmodium falciparum dipeptidyl aminopeptidase 1. Molecular and Biochemical Parasitology. 175: 10-20. PMID 20833209 DOI: 10.1016/J.Molbiopara.2010.08.004  0.379
2011 Mahajan SS, Deu E, Lauterwasser EMW, Leyva MJ, Ellman JA, Bogyo M, Renslo AR. Inside Cover: A Fragmenting Hybrid Approach for Targeted Delivery of Multiple Therapeutic Agents to the Malaria Parasite (ChemMedChem 3/2011) Chemmedchem. 6: 382-382. DOI: 10.1002/Cmdc.201190006  0.324
2010 Puri AW, Lupardus PJ, Deu E, Albrow VE, Garcia KC, Bogyo M, Shen A. Rational design of inhibitors and activity-based probes targeting Clostridium difficile virulence factor TcdB. Chemistry & Biology. 17: 1201-11. PMID 21095570 DOI: 10.1016/J.Chembiol.2010.09.011  0.447
2010 Deu E, Leyva MJ, Albrow VE, Rice MJ, Ellman JA, Bogyo M. Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probes. Chemistry & Biology. 17: 808-19. PMID 20797610 DOI: 10.1016/J.Chembiol.2010.06.007  0.454
2010 Deu E, Yang Z, Wang F, Klemba M, Bogyo M. Use of activity-based probes to develop high throughput screening assays that can be performed in complex cell extracts. Plos One. 5: e11985. PMID 20700487 DOI: 10.1371/Journal.Pone.0011985  0.356
2010 Konjar S, Yin F, Bogyo M, Turk B, Kopitar-Jerala N. Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages. Febs Letters. 584: 2201-6. PMID 20338168 DOI: 10.1016/J.Febslet.2010.03.031  0.303
2010 Bogyo M. Finding enzymes that are actively involved in cancer. Proceedings of the National Academy of Sciences of the United States of America. 107: 2379-80. PMID 20133631 DOI: 10.1073/Pnas.0914955107  0.38
2010 Lee J, Bogyo M. Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain. Acs Chemical Biology. 5: 233-43. PMID 20017516 DOI: 10.1021/Cb900232A  0.409
2010 Drag M, Bogyo M, Ellman JA, Salvesen GS. Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors. The Journal of Biological Chemistry. 285: 3310-8. PMID 19948737 DOI: 10.1074/Jbc.M109.060418  0.403
2009 Ravindran S, Lodoen MB, Verhelst SH, Bogyo M, Boothroyd JC. 4-Bromophenacyl bromide specifically inhibits rhoptry secretion during Toxoplasma invasion. Plos One. 4: e8143. PMID 19956582 DOI: 10.1371/Journal.Pone.0008143  0.432
2009 Shen A, Lupardus PJ, Morell M, Ponder EL, Sadaghiani AM, Garcia KC, Bogyo M. Simplified, enhanced protein purification using an inducible, autoprocessing enzyme tag. Plos One. 4: e8119. PMID 19956581 DOI: 10.1371/Journal.Pone.0008119  0.789
2009 Horn M, Nussbaumerová M, Sanda M, Kovárová Z, Srba J, Franta Z, Sojka D, Bogyo M, Caffrey CR, Kopácek P, Mares M. Hemoglobin digestion in blood-feeding ticks: mapping a multipeptidase pathway by functional proteomics. Chemistry & Biology. 16: 1053-63. PMID 19875079 DOI: 10.1016/J.Chembiol.2009.09.009  0.418
2009 Blum G, Weimer RM, Edgington LE, Adams W, Bogyo M. Comparative assessment of substrates and activity based probes as tools for non-invasive optical imaging of cysteine protease activity. Plos One. 4: e6374. PMID 19636372 DOI: 10.1371/Journal.Pone.0006374  0.402
2009 Lee JT, Chen DY, Yang Z, Ramos AD, Hsieh JJ, Bogyo M. Design, syntheses, and evaluation of Taspase1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 5086-90. PMID 19631530 DOI: 10.1016/J.Bmcl.2009.07.045  0.415
2009 Puri AW, Bogyo M. Using small molecules to dissect mechanisms of microbial pathogenesis. Acs Chemical Biology. 4: 603-16. PMID 19606820 DOI: 10.1021/Cb9001409  0.39
2009 Edgington LE, Berger AB, Blum G, Albrow VE, Paulick MG, Lineberry N, Bogyo M. Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes. Nature Medicine. 15: 967-73. PMID 19597506 DOI: 10.1038/Nm.1938  0.776
2009 Larson ET, Parussini F, Huynh MH, Giebel JD, Kelley AM, Zhang L, Bogyo M, Merritt EA, Carruthers VB. Toxoplasma gondii cathepsin L is the primary target of the invasion-inhibitory compound morpholinurea-leucyl-homophenyl-vinyl sulfone phenyl. The Journal of Biological Chemistry. 284: 26839-50. PMID 19596863 DOI: 10.1074/Jbc.M109.003780  0.426
2009 Shen A, Lupardus PJ, Albrow VE, Guzzetta A, Powers JC, Garcia KC, Bogyo M. Mechanistic and structural insights into the proteolytic activation of Vibrio cholerae MARTX toxin. Nature Chemical Biology. 5: 469-78. PMID 19465933 DOI: 10.1038/Nchembio.178  0.398
2009 Chang SH, Kanasaki K, Gocheva V, Blum G, Harper J, Moses MA, Shih SC, Nagy JA, Joyce J, Bogyo M, Kalluri R, Dvorak HF. VEGF-A induces angiogenesis by perturbing the cathepsin-cysteine protease inhibitor balance in venules, causing basement membrane degradation and mother vessel formation. Cancer Research. 69: 4537-44. PMID 19435903 DOI: 10.1158/0008-5472.Can-08-4539  0.31
2009 Beckham SA, Piedrafita D, Phillips CI, Samarawickrema N, Law RH, Smooker PM, Quinsey NS, Irving JA, Greenwood D, Verhelst SH, Bogyo M, Turk B, Coetzer TH, Wijeyewickrema LC, Spithill TW, et al. A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites. The International Journal of Biochemistry & Cell Biology. 41: 1601-12. PMID 19401154 DOI: 10.1016/J.Biocel.2009.02.003  0.424
2009 Barbero S, Mielgo A, Torres V, Teitz T, Shields DJ, Mikolon D, Bogyo M, Barilà D, Lahti JM, Schlaepfer D, Stupack DG. Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis. Cancer Research. 69: 3755-63. PMID 19383910 DOI: 10.1158/0008-5472.Can-08-3937  0.33
2009 Cavallo-Medved D, Rudy D, Blum G, Bogyo M, Caglic D, Sloane BF. Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation. Experimental Cell Research. 315: 1234-46. PMID 19331819 DOI: 10.1016/J.Yexcr.2009.01.021  0.348
2009 Pungercar JR, Caglic D, Sajid M, Dolinar M, Vasiljeva O, Pozgan U, Turk D, Bogyo M, Turk V, Turk B. Autocatalytic processing of procathepsin B is triggered by proenzyme activity. The Febs Journal. 276: 660-8. PMID 19143833 DOI: 10.1111/J.1742-4658.2008.06815.X  0.34
2009 Liz MA, Fleming CE, Nunes AF, Almeida MR, Mar FM, Choe Y, Craik CS, Powers JC, Bogyo M, Sousa MM. Substrate specificity of transthyretin: identification of natural substrates in the nervous system. The Biochemical Journal. 419: 467-74. PMID 19138167 DOI: 10.1042/Bj20082090  0.379
2009 Bogyo M. Metabolomics cuts to the chase to chase the cuts. Nature Chemical Biology. 5: 5-6. PMID 19088710 DOI: 10.1038/Nchembio0109-5  0.352
2009 Fonović M, Bogyo M. Activity-based probes as a tool for functional proteomic analysis of proteases. Expert Review of Proteomics. 5: 721-30. PMID 18937562 DOI: 10.1586/14789450.5.5.721  0.441
2009 Yang Z, Fonović M, Verhelst SH, Blum G, Bogyo M. Evaluation of alpha,beta-unsaturated ketone-based probes for papain-family cysteine proteases. Bioorganic & Medicinal Chemistry. 17: 1071-8. PMID 18343672 DOI: 10.1016/J.Bmc.2008.02.089  0.379
2009 Lyo V, Amadesi S, Grady EF, Bogyo M, Bunnett NW, Kirkwood KS. T1818 Profiling Protease Activation with Novel Activity-Based Probes in Experimental Acute Pancreatitis Gastroenterology. 136. DOI: 10.1016/S0016-5085(09)62699-8  0.31
2009 Maher K, Konjar Š, Čeru S, Bogyo M, Turk B, Kopitar-Jerala N. Intracellular inhibitors of cysteine cathepsins in activated macrophages Cytokine. 48: 24. DOI: 10.1016/J.Cyto.2009.07.095  0.379
2008 Lupardus PJ, Shen A, Bogyo M, Garcia KC. Small molecule-induced allosteric activation of the Vibrio cholerae RTX cysteine protease domain. Science (New York, N.Y.). 322: 265-8. PMID 18845756 DOI: 10.1126/Science.1162403  0.35
2008 Shen A, Bogyo M. Friend or Foe? Turning a Host Defense Protein Into a Pathogen's Accomplice Chemistry and Biology. 15: 879-880. PMID 18804024 DOI: 10.1016/J.Chembiol.2008.09.001  0.348
2008 Kaschani F, Verhelst SH, van Swieten PF, Verdoes M, Wong CS, Wang Z, Kaiser M, Overkleeft HS, Bogyo M, van der Hoorn RA. Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using 'click chemistry'. The Plant Journal : For Cell and Molecular Biology. 57: 373-85. PMID 18786180 DOI: 10.1111/J.1365-313X.2008.03683.X  0.367
2008 Schurigt U, Sevenich L, Vannier C, Gajda M, Schwinde A, Werner F, Stahl A, Elverfeldt Dv, Becker A, Bogyo M, Peters C, Reinheckel T. Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model. Biological Chemistry. 389: 1067-1074. PMID 18710344 DOI: 10.1515/Bc.2008.115  0.311
2008 Paulick MG, Bogyo M. Application of activity-based probes to the study of enzymes involved in cancer progression. Current Opinion in Genetics & Development. 18: 97-106. PMID 18294838 DOI: 10.1016/J.Gde.2007.12.001  0.393
2008 Arastu-Kapur S, Ponder EL, Fonović UP, Yeoh S, Yuan F, Fonović M, Grainger M, Phillips CI, Powers JC, Bogyo M. Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum. Nature Chemical Biology. 4: 203-13. PMID 18246061 DOI: 10.1038/Nchembio.70  0.804
2007 Ponder EL, Bogyo M. Ubiquitin-like modifiers and their deconjugating enzymes in medically important parasitic protozoa. Eukaryotic Cell. 6: 1943-52. PMID 17905920 DOI: 10.1128/Ec.00282-07  0.78
2007 Goulet B, Sansregret L, Leduy L, Bogyo M, Weber E, Chauhan SS, Nepveu A. Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation. Molecular Cancer Research : McR. 5: 899-907. PMID 17855659 DOI: 10.1158/1541-7786.Mcr-07-0160  0.333
2007 Blum G, von Degenfeld G, Merchant MJ, Blau HM, Bogyo M. Noninvasive optical imaging of cysteine protease activity using fluorescently quenched activity-based probes. Nature Chemical Biology. 3: 668-77. PMID 17828252 DOI: 10.1038/Nchembio.2007.26  0.386
2007 Bogyo M. Finding the needles in the haystack: mapping constitutive proteolytic events in vivo Biochemical Journal. 407. PMID 17822382 DOI: 10.1042/Bj20071096  0.343
2007 Bell-McGuinn KM, Garfall AL, Bogyo M, Hanahan D, Joyce JA. Inhibition of cysteine cathepsin protease activity enhances chemotherapy regimens by decreasing tumor growth and invasiveness in a mouse model of multistage cancer. Cancer Research. 67: 7378-85. PMID 17671208 DOI: 10.1158/0008-5472.Can-07-0602  0.326
2007 Fonović M, Verhelst SH, Sorum MT, Bogyo M. Proteomics evaluation of chemically cleavable activity-based probes. Molecular & Cellular Proteomics : McP. 6: 1761-70. PMID 17615255 DOI: 10.1074/Mcp.M700124-Mcp200  0.409
2007 Sadaghiani AM, Verhelst SH, Gocheva V, Hill K, Majerova E, Stinson S, Joyce JA, Bogyo M. Design, synthesis, and evaluation of in vivo potency and selectivity of epoxysuccinyl-based inhibitors of papain-family cysteine proteases. Chemistry & Biology. 14: 499-511. PMID 17524981 DOI: 10.1016/J.Chembiol.2007.03.010  0.411
2007 Rose PP, Bogyo M, Moses AV, Früh K. Insulin-Like Growth Factor II Receptor-Mediated Intracellular Retention of Cathepsin B Is Essential for Transformation of Endothelial Cells by Kaposi's Sarcoma-Associated Herpesvirus Journal of Virology. 81: 8050-8062. PMID 17507477 DOI: 10.1128/Jvi.00249-07  0.323
2007 Sojka D, Hajdusek O, Dvorák J, Sajid M, Franta Z, Schneider EL, Craik CS, Vancová M, Buresová V, Bogyo M, Sexton KB, McKerrow JH, Caffrey CR, Kopácek P. IrAE: an asparaginyl endopeptidase (legumain) in the gut of the hard tick Ixodes ricinus. International Journal For Parasitology. 37: 713-24. PMID 17336985 DOI: 10.1016/J.Ijpara.2006.12.020  0.421
2007 Fonović M, Bogyo M. Activity based probes for proteases: applications to biomarker discovery, molecular imaging and drug screening. Current Pharmaceutical Design. 13: 253-61. PMID 17313359 DOI: 10.2174/138161207779313623  0.428
2007 Cuerrier D, Moldoveanu T, Campbell RL, Kelly J, Yoruk B, Verhelst SH, Greenbaum D, Bogyo M, Davies PL. Development of calpain-specific inactivators by screening of positional scanning epoxide libraries. The Journal of Biological Chemistry. 282: 9600-11. PMID 17218315 DOI: 10.1074/Jbc.M610372200  0.353
2007 Verhelst SHL, Fonović M, Bogyo M. A mild chemically cleavable linker system for functional proteomic applications. Angewandte Chemie. 46: 1284-1286. PMID 17205587 DOI: 10.1002/Anie.200603811  0.413
2007 Sexton KB, Witte MD, Blum G, Bogyo M. Design of cell-permeable, fluorescent activity-based probes for the lysosomal cysteine protease asparaginyl endopeptidase (AEP)/legumain Bioorganic and Medicinal Chemistry Letters. 17: 649-653. PMID 17189693 DOI: 10.1016/J.Bmcl.2006.10.100  0.387
2007 Sadaghiani AM, Verhelst SHL, Bogyo M. Tagging and detection strategies for activity-based proteomics. Current Opinion in Chemical Biology. 11: 20-28. PMID 17174138 DOI: 10.1016/J.Cbpa.2006.11.030  0.441
2007 Sexton KB, Kato D, Berger AB, Fonovic M, Verhelst SHL, Bogyo M. Specificity of aza-peptide electrophile activity-based probes of caspases Cell Death and Differentiation. 14: 727-732. PMID 17170749 DOI: 10.1038/Sj.Cdd.4402074  0.811
2007 Teo CF, Zhou XW, Bogyo M, Carruthers VB. Cysteine protease inhibitors block Toxoplasma gondii microneme secretion and cell invasion. Antimicrobial Agents and Chemotherapy. 51: 679-88. PMID 17145790 DOI: 10.1128/Aac.01059-06  0.434
2007 Bogyo M. Screening for selective small molecule inhibitors of the proteasome using activity-based probes. Methods in Enzymology. 399: 609-22. PMID 16338384 DOI: 10.1016/S0076-6879(05)99040-X  0.309
2007 Bogyo M. Screening for selective small molecule inhibitors of the proteasome using activity-based probes. Methods in Enzymology. 399: 609-22. PMID 16338384 DOI: 10.1016/S0076-6879(05)99040-X  0.309
2006 Berger AB, Sexton KB, Bogyo M. Commonly used caspase inhibitors designed based on substrate specificity profiles lack selectivity Cell Research. 16: 961-963. PMID 17117159 DOI: 10.1038/Sj.Cr.7310112  0.783
2006 Sadaghiani AM, Verhelst SHL, Bogyo M. Solid-phase methods for the preparation of epoxysuccinate-based inhibitors of cysteine proteases. Acs Combinatorial Science. 8: 802-804. PMID 17096566 DOI: 10.1021/Cc0601027  0.405
2006 Pandey KC, Singh N, Arastu-Kapur S, Bogyo M, Rosenthal PJ. Falstatin, a cysteine protease inhibitor of Plasmodium falciparum, facilitates erythrocyte invasion. Plos Pathogens. 2. PMID 17083274 DOI: 10.1371/Journal.Ppat.0020117  0.435
2006 Denault JB, Békés M, Scott FL, Sexton KM, Bogyo M, Salvesen GS. Engineered hybrid dimers: tracking the activation pathway of caspase-7. Molecular Cell. 23: 523-33. PMID 16916640 DOI: 10.1016/J.Molcel.2006.06.020  0.324
2006 Berger AB, Witte MD, Denault JB, Sadaghiani AM, Sexton KM, Salvesen GS, Bogyo M. Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes. Molecular Cell. 23: 509-21. PMID 16916639 DOI: 10.1016/J.Molcel.2006.06.021  0.789
2006 Yuan F, Verhelst SH, Blum G, Coussens LM, Bogyo M. A selective activity-based probe for the papain family cysteine protease dipeptidyl peptidase I/cathepsin C. Journal of the American Chemical Society. 128: 5616-7. PMID 16637611 DOI: 10.1021/Ja060835V  0.389
2006 Bogyo M. Metalloproteases see the light. Nature Chemical Biology. 2: 229-30. PMID 16619018 DOI: 10.1038/Nchembio0506-229  0.369
2006 Verhelst SHL, Witte MD, Arastu-Kapur S, Fonovic M, Bogyo M. Novel Aza Peptide Inhibitors and Active-Site Probes of Papain-Family Cysteine Proteases Chembiochem. 7: 943-950. PMID 16607671 DOI: 10.1002/Cbic.200600001  0.436
2006 Pan Z, Jeffery DA, Chehade K, Beltman J, Clark JM, Grothaus P, Bogyo M, Baruch A. Development of activity-based probes for trypsin-family serine proteases. Bioorganic & Medicinal Chemistry Letters. 16: 2882-5. PMID 16554154 DOI: 10.1016/J.Bmcl.2006.03.012  0.427
2006 Choe Y, Leonetti F, Greenbaum DC, Lecaille F, Bogyo M, Brömme D, Ellman JA, Craik CS. Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities. The Journal of Biological Chemistry. 281: 12824-32. PMID 16520377 DOI: 10.1074/Jbc.M513331200  0.394
2006 Bogyo M, Blum G, von Degenfeld G, Blau H. ID: 197 In vivo Imaging of protease activity using fluorescent activity based probes Journal of Thrombosis and Haemostasis. 4: 44-44. DOI: 10.1111/J.1538-7836.2006.00197.X  0.336
2005 Blum G, Mullins SR, Keren K, Fonovic M, Jedeszko C, Rice MJ, Sloane BF, Bogyo M. Dynamic imaging of protease activity with fluorescently quenched activity-based probes. Nature Chemical Biology. 1: 203-9. PMID 16408036 DOI: 10.1038/Nchembio728  0.425
2005 Kato D, Boatright KM, Berger AB, Nazif T, Blum G, Ryan C, Chehade KA, Salvesen GS, Bogyo M. Activity-based probes that target diverse cysteine protease families. Nature Chemical Biology. 1: 33-8. PMID 16407991 DOI: 10.1038/Nchembio707  0.806
2005 Kato D, Verhelst SHL, Sexton KB, Bogyo M. A general solid phase method for the preparation of diverse azapeptide probes directed against cysteine proteases Organic Letters. 7: 5649-5652. PMID 16321013 DOI: 10.1021/Ol052275V  0.33
2005 Phillips CI, Bogyo M. Proteomics meets microbiology: technical advances in the global mapping of protein expression and function. Cellular Microbiology. 7: 1061-76. PMID 16008574 DOI: 10.1111/J.1462-5822.2005.00554.X  0.36
2005 Verhelst SHL, Bogyo M. Solid-phase synthesis of double-headed epoxysuccinyl activity-based probes for selective targeting of papain family cysteine proteases. Chembiochem. 6: 824-827. PMID 15776409 DOI: 10.1002/Cbic.200400377  0.478
2005 Verhelst SHL, Bogyo M. Chemical proteomics applied to target identification and drug discovery. Biotechniques. 38: 175-177. PMID 15727120 DOI: 10.2144/05382Te01  0.441
2005 Borodovsky A, Ovaa H, Meester WJ, Venanzi ES, Bogyo MS, Hekking BG, Ploegh HL, Kessler BM, Overkleeft HS. Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases. Chembiochem : a European Journal of Chemical Biology. 6: 287-91. PMID 15651044 DOI: 10.1002/Cbic.200400236  0.609
2005 Bogyo M, Chehade KA, Baruch A, Verhelst SH. An Improved Preparation of the Activity-Based Probe JPM-OEt and In Situ Applications Synthesis. 2005: 240-244. DOI: 10.1055/S-2004-837295  0.369
2005 Verhelst SHL, Bogyo M. Dissecting Protein Function Using Chemical Proteomic Methods Qsar & Combinatorial Science. 24: 261-269. DOI: 10.1002/Qsar.200420070  0.412
2004 Bogyo M, Baruch A, Jeffery DA, Greenbaum D, Borodovsky A, Ovaa H, Kessler B. Applications for chemical probes of proteolytic activity. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 21.17. PMID 18429259 DOI: 10.1002/0471140864.Ps2117S36  0.452
2004 Berger AB, Vitorino PM, Bogyo M. Activity-based protein profiling: applications to biomarker discovery, in vivo imaging and drug discovery. American Journal of Pharmacogenomics : Genomics-Related Research in Drug Development and Clinical Practice. 4: 371-81. PMID 15651898 DOI: 10.2165/00129785-200404060-00004  0.801
2004 Snipas SJ, Wildfang E, Nazif T, Christensen L, Boatright KM, Bogyo M, Stennicke HR, Salvesen GS. Characteristics of the caspase-like catalytic domain of human paracaspase. Biological Chemistry. 385: 1093-8. PMID 15576331 DOI: 10.1515/Bc.2004.142  0.39
2004 van der Hoorn RA, Leeuwenburgh MA, Bogyo M, Joosten MH, Peck SC. Activity profiling of papain-like cysteine proteases in plants. Plant Physiology. 135: 1170-8. PMID 15266051 DOI: 10.1104/Pp.104.041467  0.431
2004 Oleksy A, Golonka E, BaÅ„buÅ‚a A, Szmyd G, Moon J, Kubica M, Greenbaum D, Bogyo M, Foster TJ, Travis J, Potempa J. Growth phase-dependent production of a cell wall-associated elastinolytic cysteine proteinase by Staphylococcus epidermidis. Biological Chemistry. 385: 525-35. PMID 15255185 DOI: 10.1515/Bc.2004.062  0.356
2004 Hook V, Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Troutner K, Toneff T, Bundey R, Logrinova A, Reinheckel T, Peters C, Bogyo M. Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones. Biological Chemistry. 385: 473-80. PMID 15255178 DOI: 10.1515/Bc.2004.055  0.316
2004 Eksi S, Czesny B, Greenbaum DC, Bogyo M, Williamson KC. Targeted disruption of Plasmodium falciparum cysteine protease, falcipain 1, reduces oocyst production, not erythrocytic stage growth. Molecular Microbiology. 53: 243-50. PMID 15225318 DOI: 10.1111/J.1365-2958.2004.04108.X  0.363
2004 Yasuda Y, Li Z, Greenbaum D, Bogyo M, Weber E, Brömme D. Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages. The Journal of Biological Chemistry. 279: 36761-70. PMID 15192101 DOI: 10.1074/Jbc.M403986200  0.341
2004 Joyce JA, Baruch A, Chehade K, Meyer-Morse N, Giraudo E, Tsai FY, Greenbaum DC, Hager JH, Bogyo M, Hanahan D. Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis. Cancer Cell. 5: 443-53. PMID 15144952 DOI: 10.1016/S1535-6108(04)00111-4  0.341
2004 Goulet B, Baruch A, Moon NS, Poirier M, Sansregret LL, Erickson A, Bogyo M, Nepveu A. A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor. Molecular Cell. 14: 207-19. PMID 15099520 DOI: 10.1016/S1097-2765(04)00209-6  0.357
2004 Medzihradszky KF, Darula Z, Perlson E, Fainzilber M, Chalkley RJ, Ball H, Greenbaum D, Bogyo M, Tyson DR, Bradshaw RA, Burlingame AL. O-sulfonation of serine and threonine: mass spectrometric detection and characterization of a new posttranslational modification in diverse proteins throughout the eukaryotes. Molecular & Cellular Proteomics : McP. 3: 429-40. PMID 14752058 DOI: 10.1074/Mcp.M300140-Mcp200  0.391
2004 Baruch A, Jeffery DA, Bogyo M. Enzyme activity--it's all about image. Trends in Cell Biology. 14: 29-35. PMID 14729178 DOI: 10.1016/J.Tcb.2003.11.002  0.417
2004 Li Z, Yasuda Y, Li W, Bogyo M, Katz N, Gordon RE, Fields GB, Brömme D. Regulation of collagenase activities of human cathepsins by glycosaminoglycans. The Journal of Biological Chemistry. 279: 5470-9. PMID 14645229 DOI: 10.1074/Jbc.M310349200  0.347
2003 Sajid M, McKerrow JH, Hansell E, Mathieu MA, Lucas KD, Hsieh I, Greenbaum D, Bogyo M, Salter JP, Lim KC, Franklin C, Kim JH, Caffrey CR. Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase. Molecular and Biochemical Parasitology. 131: 65-75. PMID 12967713 DOI: 10.1016/S0166-6851(03)00194-4  0.438
2003 Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Toneff T, Bundey R, Miller R, Schilling B, Petermann I, Dehnert J, Logvinova A, Goldsmith P, Neveu JM, Lane WS, Gibson B, Reinheckel T, ... ... Bogyo M, et al. Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proceedings of the National Academy of Sciences of the United States of America. 100: 9590-5. PMID 12869695 DOI: 10.1073/Pnas.1531542100  0.355
2003 Rozman-Pungerčar J, Kopitar-Jerala N, Bogyo M, Turk D, Vasiljeva O, Štefe I, Vandenabeele P, Brömme D, Puizdar V, Fonović M, Trstenjak-Prebanda M, Dolenc I, Turk V, Turk B. Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity Cell Death & Differentiation. 10: 881-888. PMID 12867995 DOI: 10.1038/Sj.Cdd.4401247  0.385
2003 Wang CC, Bozdech Z, Liu CL, Shipway A, Backes BJ, Harris JL, Bogyo M. Biochemical analysis of the 20 S proteasome of Trypanosoma brucei. The Journal of Biological Chemistry. 278: 15800-8. PMID 12600991 DOI: 10.1074/Jbc.M300195200  0.332
2003 Jeffery DA, Bogyo M. Chemical proteomics and its application to drug discovery. Current Opinion in Biotechnology. 14: 87-95. PMID 12566007 DOI: 10.1016/S0958-1669(02)00010-1  0.349
2003 Mikolajczyk J, Boatright KM, Stennicke HR, Nazif T, Potempa J, Bogyo M, Salvesen GS. Sequential autolytic processing activates the zymogen of Arg-gingipain. The Journal of Biological Chemistry. 278: 10458-64. PMID 12533545 DOI: 10.1074/Jbc.M210564200  0.381
2003 Kessler B, Hong X, Petrovic J, Borodovsky A, Dantuma NP, Bogyo M, Overkleeft HS, Ploegh H, Glas R. Pathways accessory to proteasomal proteolysis are less efficient in major histocompatibility complex class I antigen production. The Journal of Biological Chemistry. 278: 10013-21. PMID 12488316 DOI: 10.1074/Jbc.M211221200  0.513
2002 Greenbaum DC, Baruch A, Grainger M, Bozdech Z, Medzihradszky KF, Engel J, DeRisi J, Holder AA, Bogyo M. A role for the protease falcipain 1 in host cell invasion by the human malaria parasite. Science (New York, N.Y.). 298: 2002-6. PMID 12471262 DOI: 10.1126/Science.1077426  0.432
2002 Greenbaum DC, Arnold WD, Lu F, Hayrapetian L, Baruch A, Krumrine J, Toba S, Chehade K, Brömme D, Kuntz ID, Bogyo M. Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design. Chemistry & Biology. 9: 1085-94. PMID 12401493 DOI: 10.1016/S1074-5521(02)00238-7  0.421
2002 Greenbaum D, Baruch A, Hayrapetian L, Darula Z, Burlingame A, Medzihradszky KF, Bogyo M. Chemical approaches for functionally probing the proteome. Molecular & Cellular Proteomics : McP. 1: 60-8. PMID 12096141 DOI: 10.1074/Mcp.T100003-Mcp200  0.447
2002 Bogyo M, Wang EW. Proteasome inhibitors: complex tools for a complex enzyme. Current Topics in Microbiology and Immunology. 268: 185-208. PMID 12083006 DOI: 10.1007/978-3-642-59414-4_8  0.445
2002 Groll M, Nazif T, Huber R, Bogyo M. Probing structural determinants distal to the site of hydrolysis that control substrate specificity of the 20S proteasome. Chemistry & Biology. 9: 655-62. PMID 12031672 DOI: 10.1016/S1074-5521(02)00144-8  0.346
2002 Mathieu MA, Bogyo M, Caffrey CR, Choe Y, Lee J, Chapman H, Sajid M, Craik CS, McKerrow JH. Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries Molecular and Biochemical Parasitology. 121: 99-105. PMID 11985866 DOI: 10.1016/S0166-6851(02)00026-9  0.307
2001 Caffrey CR, Hansell E, Lucas KD, Brinen LS, Alvarez Hernandez A, Cheng J, Gwaltney SL, Roush WR, Stierhof YD, Bogyo M, Steverding D, McKerrow JH. Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense. Molecular and Biochemical Parasitology. 118: 61-73. PMID 11704274 DOI: 10.1016/S0166-6851(01)00368-1  0.443
2001 Li J, Gao X, Ortega J, Nazif T, Joss L, Bogyo M, Steven AC, Rechsteiner M. Lysine 188 substitutions convert the pattern of proteasome activation by REGgamma to that of REGs alpha and beta. The Embo Journal. 20: 3359-69. PMID 11432824 DOI: 10.1093/Emboj/20.13.3359  0.353
2001 Nazif T, Bogyo M. Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors Proceedings of the National Academy of Sciences of the United States of America. 98: 2967-2972. PMID 11248015 DOI: 10.1073/Pnas.061028898  0.385
2000 Greenbaum D, Medzihradszky KF, Burlingame A, Bogyo M. Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools Chemistry and Biology. 7: 569-581. PMID 11048948 DOI: 10.1016/S1074-5521(00)00014-4  0.355
2000 Wang EW, Kessler BM, Borodovsky A, Cravatt BF, Bogyo M, Ploegh HL, Glas R. Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity. Proceedings of the National Academy of Sciences of the United States of America. 97: 9990-5. PMID 10954757 DOI: 10.1073/Pnas.180328897  0.569
2000 Weihofen A, Lemberg MK, Ploegh HL, Bogyo M, Martoglio B. Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor. The Journal of Biological Chemistry. 275: 30951-6. PMID 10921927 DOI: 10.1074/Jbc.M005980200  0.518
2000 Caffrey CR, Mathieu MA, Gaffney AM, Salter JP, Sajid M, Lucas KD, Franklin C, Bogyo M, McKerrow JH. Identification of a cDNA encoding an active asparaginyl endopeptidase of Schistosoma mansoni and its expression in Pichia pastoris. Febs Letters. 466: 244-8. PMID 10682836 DOI: 10.1016/S0014-5793(99)01798-6  0.321
2000 Bogyo M, Verhelst S, Bellingard-Dubouchaud V, Toba S, Greenbaum D. Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs Chemistry and Biology. 7: 27-38. PMID 10662686 DOI: 10.1016/S1074-5521(00)00061-2  0.417
1999 Schmidtke G, Holzhütter H, Bogyo M, Kairies N, Groll M, Giuli Rd, Emch S, Groettrup M. How an Inhibitor of the HIV-I Protease Modulates Proteasome Activity Journal of Biological Chemistry. 274: 35734-35740. PMID 10585454 DOI: 10.1074/Jbc.274.50.35734  0.41
1999 Selzer PM, Pingel S, Hsieh I, Ugele B, Chan VJ, Engel JC, Bogyo M, Russell DG, Sakanari JA, Mckerrow JH. Cysteine protease inhibitors as chemotherapy: Lessons from a parasite target Proceedings of the National Academy of Sciences of the United States of America. 96: 11015-11022. PMID 10500116 DOI: 10.1073/Pnas.96.20.11015  0.465
1999 Bogyo M, Ploegh HL. Antigen presentation. A protease draws first blood. Nature. 396: 625, 627. PMID 9872306 DOI: 10.1038/25238  0.518
1998 Bogyo M, Shin S, McMaster JS, Ploegh HL. Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes Chemistry and Biology. 5: 307-320. PMID 9653549 DOI: 10.1016/S1074-5521(98)90169-7  0.543
1998 Glas R, Bogyo M, McMaster JS, Gaczynska M, Ploegh HL. A proteolytic system that compensates for loss of proteasome function Nature. 392: 618-622. PMID 9560160 DOI: 10.1038/33443  0.555
1998 Ruepp A, Eckerskorn C, Bogyo M, Baumeister W. Proteasome function is dispensable under normal but not under heat shock conditions in Thermoplasma acidophilum Febs Letters. 425: 87-90. PMID 9541012 DOI: 10.1016/S0014-5793(98)00205-1  0.322
1997 Bogyo M, Gaczynska M, Ploegh HL. Proteasome inhibitors and antigen presentation. Biopolymers. 43: 269-80. PMID 9316392 DOI: 10.1002/(Sici)1097-0282(1997)43:4<269::Aid-Bip2>3.0.Co;2-T  0.565
1997 Bogyo M, McMaster JS, Gaczynska M, Tortorella D, Goldberg AL, Ploegh H. Covalent modification of the active site threonine of proteasomal β subunits and the Escherichia coli homolog HsIV by a new class of inhibitors Proceedings of the National Academy of Sciences of the United States of America. 94: 6629-6634. PMID 9192616 DOI: 10.1073/Pnas.94.13.6629  0.54
1996 Wiertz EJ, Tortorella D, Bogyo M, Yu J, Mothes W, Jones TR, Rapoport TA, Ploegh HL. Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. Nature. 384: 432-8. PMID 8945469 DOI: 10.1038/384432A0  0.493
1996 Wiertz EJ, Jones TR, Sun L, Bogyo M, Geuze HJ, Ploegh HL. The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol. Cell. 84: 769-79. PMID 8625414 DOI: 10.1016/S0092-8674(00)81054-5  0.491
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