Gourisankar Ghosh - Publications

University of California, San Diego, La Jolla, CA 
transcription, signaling, pre-mRNA splicing, mRNA transport, protein-protein, protein-DNA and protein-RNA interactions

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Year Citation  Score
2019 Mulero MC, Huxford T, Ghosh G. NF-κB, IκB, and IKK: Integral Components of Immune System Signaling. Advances in Experimental Medicine and Biology. 1172: 207-226. PMID 31628658 DOI: 10.1007/978-981-13-9367-9_10  0.84
2019 Mulero MC, Wang VY, Huxford T, Ghosh G. Genome reading by the NF-κB transcription factors. Nucleic Acids Research. PMID 31501881 DOI: 10.1093/nar/gkz739  0.84
2019 Mitchell S, Mercado EL, Adelaja A, Ho JQ, Cheng QJ, Ghosh G, Hoffmann A. An NFκB Activity Calculator to Delineate Signaling Crosstalk: Type I and II Interferons Enhance NFκB via Distinct Mechanisms. Frontiers in Immunology. 10: 1425. PMID 31293585 DOI: 10.3389/fimmu.2019.01425  0.64
2018 Polley S, Huang DB, Biswas T, Ghosh G. A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α. Journal of Visualized Experiments : Jove. PMID 30451218 DOI: 10.3791/56091  0.44
2018 Mulero MC, Shahabi S, Ko MS, Schiffer JM, Huang D, Wang VY, Amaro RE, Huxford T, Ghosh G. Protein co-factors are essential for high affinity DNA binding by the nuclear factor κB RelA subunit. Biochemistry. PMID 29708732 DOI: 10.1021/acs.biochem.8b00158  0.84
2017 Mulero MC, Huang DB, Nguyen HT, Wang V, Li Y, Biswas T, Ghosh G. DNA-binding affinity and transcriptional activity of the RelA homodimer of nuclear factor kappa B are not correlated. The Journal of Biological Chemistry. PMID 28935669 DOI: 10.1074/jbc.M117.813980  0.84
2017 Wang VY, Li Y, Kim D, Zhong X, Du Q, Ghassemian M, Ghosh G. Bcl3 Phosphorylation by Akt, Erk2, and IKK Is Required for Its Transcriptional Activity. Molecular Cell. PMID 28689659 DOI: 10.1016/j.molcel.2017.06.011  0.84
2016 Polley S, Passos DO, Huang DB, Mulero MC, Mazumder A, Biswas T, Verma IM, Lyumkis D, Ghosh G. Structural Basis for the Activation of IKK1/α. Cell Reports. 17: 1907-1914. PMID 27851956 DOI: 10.1016/j.celrep.2016.10.067  0.84
2016 Fusco AJ, Mazumder A, Wang VY, Tao Z, Ware C, Ghosh G. The NF-κB subunit RelB controls p100 processing by competing with the kinases NIK and IKK1 for binding to p100. Science Signaling. 9: ra96. PMID 27678221 DOI: 10.1126/scisignal.aad9413  0.84
2016 Ghosh G, Biswas T. To Swap or Not To Swap. Structure (London, England : 1993). 24: 1436-1438. PMID 27602989 DOI: 10.1016/j.str.2016.08.004  1
2015 Song G, Sun Z, Li L, Xu X, Rawlings M, Liebscher CH, Clausen B, Poplawsky J, Leonard DN, Huang S, Teng Z, Liu CT, Asta MD, Gao Y, Dunand DC, ... Ghosh G, et al. Ferritic Alloys with Extreme Creep Resistance via Coherent Hierarchical Precipitates. Scientific Reports. 5: 16327. PMID 26548303 DOI: 10.1038/srep16327  0.36
2015 Sun Z, Song G, Ilavsky J, Ghosh G, Liaw PK. Nano-sized precipitate stability and its controlling factors in a NiAl-strengthened ferritic alloy. Scientific Reports. 5: 16081. PMID 26537060 DOI: 10.1038/srep16081  0.36
2015 Tsui R, Kearns JD, Lynch C, Vu D, Ngo KA, Basak S, Ghosh G, Hoffmann A. IκBβ enhances the generation of the low-affinity NFκB/RelA homodimer. Nature Communications. 6: 7068. PMID 25946967 DOI: 10.1038/ncomms8068  0.64
2015 Ghosh G. A first-principles study of cementite (Fe3C) and its alloyed counterparts: Elastic constants, elastic anisotropies, and isotropic elastic moduli Aip Advances. 5. DOI: 10.1063/1.4928208  0.36
2015 Razumovskiy VI, Ghosh G. A first-principles study of cementite (Fe3C) and its alloyed counterparts: Structural properties, stability, and electronic structure Computational Materials Science. 110: 169-181. DOI: 10.1016/j.commatsci.2015.08.006  0.36
2014 Tao Z, Fusco A, Huang DB, Gupta K, Young Kim D, Ware CF, Van Duyne GD, Ghosh G. p100/IκBδ sequesters and inhibits NF-κB through kappaBsome formation. Proceedings of the National Academy of Sciences of the United States of America. 111: 15946-51. PMID 25349408 DOI: 10.1073/pnas.1408552111  1
2014 Aubol BE, Plocinik RM, Keshwani MM, McGlone ML, Hagopian JC, Ghosh G, Fu XD, Adams JA. N-terminus of the protein kinase CLK1 induces SR protein hyperphosphorylation. The Biochemical Journal. 462: 143-52. PMID 24869919 DOI: 10.1042/BJ20140494  1
2014 Hauenstein AV, Rogers WE, Shaul JD, Huang DB, Ghosh G, Huxford T. Probing kinase activation and substrate specificity with an engineered monomeric IKK2. Biochemistry. 53: 2064-73. PMID 24611898 DOI: 10.1021/bi401551r  1
2013 Mukherjee SP, Behar M, Birnbaum HA, Hoffmann A, Wright PE, Ghosh G. Analysis of the RelA:CBP/p300 interaction reveals its involvement in NF-κB-driven transcription. Plos Biology. 11: e1001647. PMID 24019758 DOI: 10.1371/journal.pbio.1001647  1
2013 Lu T, Yang M, Huang DB, Wei H, Ozer GH, Ghosh G, Stark GR. Role of lysine methylation of NF-κB in differential gene regulation. Proceedings of the National Academy of Sciences of the United States of America. 110: 13510-5. PMID 23904479 DOI: 10.1073/pnas.1311770110  1
2013 Wei H, Wang B, Miyagi M, She Y, Gopalan B, Huang DB, Ghosh G, Stark GR, Lu T. PRMT5 dimethylates R30 of the p65 subunit to activate NF-κB. Proceedings of the National Academy of Sciences of the United States of America. 110: 13516-21. PMID 23904475 DOI: 10.1073/pnas.1311784110  1
2013 Polley S, Huang DB, Hauenstein AV, Fusco AJ, Zhong X, Vu D, Schröfelbauer B, Kim Y, Hoffmann A, Verma IM, Ghosh G, Huxford T. A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation. Plos Biology. 11: e1001581. PMID 23776406 DOI: 10.1371/journal.pbio.1001581  1
2013 Vu D, Huang DB, Vemu A, Ghosh G. A structural basis for selective dimerization by NF-κB RelB. Journal of Molecular Biology. 425: 1934-45. PMID 23485337 DOI: 10.1016/j.jmb.2013.02.020  1
2012 Wang VY, Huang W, Asagiri M, Spann N, Hoffmann A, Glass C, Ghosh G. The transcriptional specificity of NF-κB dimers is coded within the κB DNA response elements. Cell Reports. 2: 824-39. PMID 23063365 DOI: 10.1016/j.celrep.2012.08.042  1
2012 Tao Z, Ghosh G. Understanding NIK regulation from its structure. Structure (London, England : 1993). 20: 1615-7. PMID 23063006 DOI: 10.1016/j.str.2012.09.012  1
2012 Zhou Z, Qiu J, Liu W, Zhou Y, Plocinik RM, Li H, Hu Q, Ghosh G, Adams JA, Rosenfeld MG, Fu XD. The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus. Molecular Cell. 47: 422-33. PMID 22727668 DOI: 10.1016/j.molcel.2012.05.014  1
2012 Schröfelbauer B, Polley S, Behar M, Ghosh G, Hoffmann A. NEMO ensures signaling specificity of the pleiotropic IKKβ by directing its kinase activity toward IκBα. Molecular Cell. 47: 111-21. PMID 22633953 DOI: 10.1016/j.molcel.2012.04.020  1
2012 Ghosh G, Wang VY, Huang DB, Fusco A. NF-κB regulation: lessons from structures. Immunological Reviews. 246: 36-58. PMID 22435546 DOI: 10.1111/j.1600-065X.2012.01097.x  1
2012 Ding H, Huang S, Ghosh G, Liaw PK, Asta M. A computational study of impurity diffusivities for 5d transition metal solutes in α-Fe Scripta Materialia. 67: 732-735. DOI: 10.1016/j.scriptamat.2012.06.010  0.36
2012 Teng ZK, Liu CT, Miller MK, Ghosh G, Kenik EA, Huang S, Liaw PK. Room temperature ductility of NiAl-strengthened ferritic steels: Effects of precipitate microstructure Materials Science and Engineering A. 541: 22-27. DOI: 10.1016/j.msea.2012.01.103  0.36
2012 Teng ZK, Ghosh G, Miller MK, Huang S, Clausen B, Brown DW, Liaw PK. Neutron-diffraction study and modeling of the lattice parameters of a NiAl-precipitate-strengthened Fe-based alloy Acta Materialia. 60: 5362-5369. DOI: 10.1016/j.actamat.2012.05.033  0.36
2012 Huang S, Ghosh G, Li X, Ilavsky J, Teng Z, Liaw PK. Communication: Effect of Al on the NiAl-type B2 precipitates in ferritic superalloys Metallurgical and Materials Transactions a: Physical Metallurgy and Materials Science. 43: 3423-3427. DOI: 10.1007/s11661-012-1318-y  0.36
2011 Cho S, Hoang A, Chakrabarti S, Huynh N, Huang DB, Ghosh G. The SRSF1 linker induces semi-conservative ESE binding by cooperating with the RRMs. Nucleic Acids Research. 39: 9413-21. PMID 21852328 DOI: 10.1093/nar/gkr663  1
2011 Cho S, Hoang A, Sinha R, Zhong XY, Fu XD, Krainer AR, Ghosh G. Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly. Proceedings of the National Academy of Sciences of the United States of America. 108: 8233-8. PMID 21536904 DOI: 10.1073/pnas.1017700108  1
2011 Chawla A, Chakrabarti S, Ghosh G, Niwa M. Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase. The Journal of Cell Biology. 193: 41-50. PMID 21444691 DOI: 10.1083/jcb.201008071  1
2011 Ho JQ, Asagiri M, Hoffmann A, Ghosh G. NF-κB potentiates caspase independent hydrogen peroxide induced cell death. Plos One. 6: e16815. PMID 21347231 DOI: 10.1371/journal.pone.0016815  1
2011 Cheng CS, Feldman KE, Lee J, Verma S, Huang DB, Huynh K, Chang M, Ponomarenko JV, Sun SC, Benedict CA, Ghosh G, Hoffmann A. The specificity of innate immune responses is enforced by repression of interferon response elements by NF-κB p50. Science Signaling. 4: ra11. PMID 21343618 DOI: 10.1126/scisignal.2001501  1
2011 Ghosh G, Adams JA. Phosphorylation mechanism and structure of serine-arginine protein kinases. The Febs Journal. 278: 587-97. PMID 21205204 DOI: 10.1111/j.1742-4658.2010.07992.x  1
2011 Huxford T, Hoffmann A, Ghosh G. Understanding the logic of IκB:NF-κB regulation in structural terms. Current Topics in Microbiology and Immunology. 349: 1-24. PMID 20845107 DOI: 10.1007/82_2010_99  1
2011 Huxford T, Hoffmann A, Ghosh G. Understanding the logic of IκB:NF-κB regulation in structural terms Current Topics in Microbiology and Immunology. 349: 1-24. DOI: 10.1007/82-2010-99  1
2010 Ma CT, Ghosh G, Fu XD, Adams JA. Mechanism of dephosphorylation of the SR protein ASF/SF2 by protein phosphatase 1. Journal of Molecular Biology. 403: 386-404. PMID 20826166 DOI: 10.1016/j.jmb.2010.08.024  1
2010 Mathes E, Wang L, Komives E, Ghosh G. Flexible regions within I{kappa}B{alpha} create the ubiquitin-independent degradation signal. The Journal of Biological Chemistry. 285: 32927-36. PMID 20682784 DOI: 10.1074/jbc.M110.107326  1
2009 Huxford T, Ghosh G. A structural guide to proteins of the NF-kappaB signaling module. Cold Spring Harbor Perspectives in Biology. 1: a000075. PMID 20066103 DOI: 10.1101/cshperspect.a000075  1
2009 Bergqvist S, Alverdi V, Mengel B, Hoffmann A, Ghosh G, Komives EA. Kinetic enhancement of NF-kappaBxDNA dissociation by IkappaBalpha. Proceedings of the National Academy of Sciences of the United States of America. 106: 19328-33. PMID 19887633 DOI: 10.1073/pnas.0908797106  1
2009 Huynh N, Ma CT, Giang N, Hagopian J, Ngo J, Adams J, Ghosh G. Allosteric interactions direct binding and phosphorylation of ASF/SF2 by SRPK1. Biochemistry. 48: 11432-40. PMID 19886675 DOI: 10.1021/bi901107q  1
2009 Savinova OV, Hoffmann A, Ghosh G. The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes. Molecular Cell. 34: 591-602. PMID 19524538 DOI: 10.1016/j.molcel.2009.04.033  1
2009 Shih VF, Kearns JD, Basak S, Savinova OV, Ghosh G, Hoffmann A. Kinetic control of negative feedback regulators of NF-kappaB/RelA determines their pathogen- and cytokine-receptor signaling specificity. Proceedings of the National Academy of Sciences of the United States of America. 106: 9619-24. PMID 19487661 DOI: 10.1073/pnas.0812367106  1
2009 Ma CT, Hagopian JC, Ghosh G, Fu XD, Adams JA. Regiospecific phosphorylation control of the SR protein ASF/SF2 by SRPK1. Journal of Molecular Biology. 390: 618-34. PMID 19477182 DOI: 10.1016/j.jmb.2009.05.060  1
2009 Bullock AN, Das S, Debreczeni JE, Rellos P, Fedorov O, Niesen FH, Guo K, Papagrigoriou E, Amos AL, Cho S, Turk BE, Ghosh G, Knapp S. Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation. Structure (London, England : 1993). 17: 352-62. PMID 19278650 DOI: 10.1016/j.str.2008.12.023  1
2009 Kennedy EJ, Yang J, Pillus L, Taylor SS, Ghosh G. Identifying critical non-catalytic residues that modulate protein kinase A activity. Plos One. 4: e4746. PMID 19270744 DOI: 10.1371/journal.pone.0004746  1
2009 Zhong XY, Ding JH, Adams JA, Ghosh G, Fu XD. Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones. Genes & Development. 23: 482-95. PMID 19240134 DOI: 10.1101/gad.1752109  1
2009 Yang J, Kennedy EJ, Wu J, Deal MS, Pennypacker J, Ghosh G, Taylor SS. Contribution of non-catalytic core residues to activity and regulation in protein kinase A. The Journal of Biological Chemistry. 284: 6241-8. PMID 19122195 DOI: 10.1074/jbc.M805862200  1
2009 Fusco AJ, Huang DB, Miller D, Wang VY, Vu D, Ghosh G. NF-kappaB p52:RelB heterodimer recognizes two classes of kappaB sites with two distinct modes. Embo Reports. 10: 152-9. PMID 19098713 DOI: 10.1038/embor.2008.227  1
2008 Bergqvist S, Ghosh G, Komives EA. The IkappaBalpha/NF-kappaB complex has two hot spots, one at either end of the interface. Protein Science : a Publication of the Protein Society. 17: 2051-8. PMID 18824506 DOI: 10.1110/ps.037481.108  1
2008 Sen M, Ghosh G. Transcriptional outcome of Wnt-Frizzled signal transduction in inflammation: evolving concepts. Journal of Immunology (Baltimore, Md. : 1950). 181: 4441-5. PMID 18802045  1
2008 Hagopian JC, Ma CT, Meade BR, Albuquerque CP, Ngo JC, Ghosh G, Jennings PA, Fu XD, Adams JA. Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1. Journal of Molecular Biology. 382: 894-909. PMID 18687337 DOI: 10.1016/j.jmb.2008.07.055  1
2008 Truhlar SM, Mathes E, Cervantes CF, Ghosh G, Komives EA. Pre-folding IkappaBalpha alters control of NF-kappaB signaling. Journal of Molecular Biology. 380: 67-82. PMID 18511071 DOI: 10.1016/j.jmb.2008.02.053  1
2008 Mathes E, O'Dea EL, Hoffmann A, Ghosh G. NF-kappaB dictates the degradation pathway of IkappaBalpha. The Embo Journal. 27: 1357-67. PMID 18401342 DOI: 10.1038/emboj.2008.73  1
2008 Ngo JC, Giang K, Chakrabarti S, Ma CT, Huynh N, Hagopian JC, Dorrestein PC, Fu XD, Adams JA, Ghosh G. A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1. Molecular Cell. 29: 563-76. PMID 18342604 DOI: 10.1016/j.molcel.2007.12.017  1
2008 Fusco AJ, Savinova OV, Talwar R, Kearns JD, Hoffmann A, Ghosh G. Stabilization of RelB requires multidomain interactions with p100/p52. The Journal of Biological Chemistry. 283: 12324-32. PMID 18321863 DOI: 10.1074/jbc.M707898200  1
2008 Ma CT, Velazquez-Dones A, Hagopian JC, Ghosh G, Fu XD, Adams JA. Ordered multi-site phosphorylation of the splicing factor ASF/SF2 by SRPK1. Journal of Molecular Biology. 376: 55-68. PMID 18155240 DOI: 10.1016/j.jmb.2007.08.029  1
2008 Kennedy EJ, Ghosh G, Pillus L. Identification of functionally distinct regions that mediate biological activity of the protein kinase a homolog Tpk2. The Journal of Biological Chemistry. 283: 1084-93. PMID 17971450 DOI: 10.1074/jbc.M704028200  1
2008 Mathes E, O'Dea EL, Hoffmann A, Ghosh G. NF-κB dictates the degradation pathway of IκBα (EMBO Journal (2008) DOI: 10.1038/emboj.2008.73) Embo Journal. 27: 1421. DOI: 10.1038/emboj.2008.91  1
2007 Drew D, Shimada E, Huynh K, Bergqvist S, Talwar R, Karin M, Ghosh G. Inhibitor kappaB kinase beta binding by inhibitor kappaB kinase gamma. Biochemistry. 46: 12482-90. PMID 17924664 DOI: 10.1021/bi701137a  1
2007 Moorthy AK, Huang DB, Wang VY, Vu D, Ghosh G. X-ray structure of a NF-kappaB p50/RelB/DNA complex reveals assembly of multiple dimers on tandem kappaB sites. Journal of Molecular Biology. 373: 723-34. PMID 17869269 DOI: 10.1016/j.jmb.2007.08.039  1
2007 Shaw SD, Chakrabarti S, Ghosh G, Krainer AR. Deletion of the N-terminus of SF2/ASF permits RS-domain-independent pre-mRNA splicing. Plos One. 2: e854. PMID 17786225 DOI: 10.1371/journal.pone.0000854  1
2007 Lukasiewicz R, Velazquez-Dones A, Huynh N, Hagopian J, Fu XD, Adams J, Ghosh G. Structurally unique yeast and mammalian serine-arginine protein kinases catalyze evolutionarily conserved phosphorylation reactions. The Journal of Biological Chemistry. 282: 23036-43. PMID 17517895 DOI: 10.1074/jbc.M611305200  1
2007 Basak S, Kim H, Kearns JD, Tergaonkar V, O'Dea E, Werner SL, Benedict CA, Ware CF, Ghosh G, Verma IM, Hoffmann A. A fourth IkappaB protein within the NF-kappaB signaling module. Cell. 128: 369-81. PMID 17254973 DOI: 10.1016/j.cell.2006.12.033  1
2007 Lukasiewicz R, Nolen B, Adams JA, Ghosh G. The RGG domain of Npl3p recruits Sky1p through docking interactions. Journal of Molecular Biology. 367: 249-61. PMID 17239901 DOI: 10.1016/j.jmb.2006.12.031  1
2007 Ngo JC, Gullingsrud J, Giang K, Yeh MJ, Fu XD, Adams JA, McCammon JA, Ghosh G. SR protein kinase 1 is resilient to inactivation. Structure (London, England : 1993). 15: 123-33. PMID 17223538 DOI: 10.1016/j.str.2006.11.011  1
2006 Hoffmann A, Natoli G, Ghosh G. Transcriptional regulation via the NF-kappaB signaling module. Oncogene. 25: 6706-16. PMID 17072323 DOI: 10.1038/sj.onc.1209933  1
2006 Huxford T, Ghosh G. Inhibition of transcription factor NF-kappaB activation by kappaB-Ras. Methods in Enzymology. 407: 527-34. PMID 16757350 DOI: 10.1016/S0076-6879(05)07042-4  1
2006 Bergqvist S, Croy CH, Kjaergaard M, Huxford T, Ghosh G, Komives EA. Thermodynamics reveal that helix four in the NLS of NF-kappaB p65 anchors IkappaBalpha, forming a very stable complex. Journal of Molecular Biology. 360: 421-34. PMID 16756995 DOI: 10.1016/j.jmb.2006.05.014  1
2006 Moorthy AK, Savinova OV, Ho JQ, Wang VY, Vu D, Ghosh G. The 20S proteasome processes NF-kappaB1 p105 into p50 in a translation-independent manner. The Embo Journal. 25: 1945-56. PMID 16619030 DOI: 10.1038/sj.emboj.7601081  1
2006 Ding JH, Zhong XY, Hagopian JC, Cruz MM, Ghosh G, Feramisco J, Adams JA, Fu XD. Regulated cellular partitioning of SR protein-specific kinases in mammalian cells. Molecular Biology of the Cell. 17: 876-85. PMID 16319169 DOI: 10.1091/mbc.E05-10-0963  1
2006 Taylor SS, Ghosh G. Protein kinases: Catalysis and regulation Current Opinion in Structural Biology. 16: 665-667. DOI: 10.1016/j.sbi.2006.11.001  1
2005 Kennedy EJ, Pillus L, Ghosh G. Pho5p and newly identified nucleotide pyrophosphatases/ phosphodiesterases regulate extracellular nucleotide phosphate metabolism in Saccharomyces cerevisiae. Eukaryotic Cell. 4: 1892-901. PMID 16278456 DOI: 10.1128/EC.4.11.1892-1901.2005  1
2005 Velazquez-Dones A, Hagopian JC, Ma CT, Zhong XY, Zhou H, Ghosh G, Fu XD, Adams JA. Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty. The Journal of Biological Chemistry. 280: 41761-8. PMID 16223727 DOI: 10.1074/jbc.M504156200  1
2005 Ngo JC, Chakrabarti S, Ding JH, Velazquez-Dones A, Nolen B, Aubol BE, Adams JA, Fu XD, Ghosh G. Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2. Molecular Cell. 20: 77-89. PMID 16209947 DOI: 10.1016/j.molcel.2005.08.025  1
2005 Taylor SS, Haste NM, Ghosh G. PKR and eIF2alpha: integration of kinase dimerization, activation, and substrate docking. Cell. 122: 823-5. PMID 16179248 DOI: 10.1016/j.cell.2005.09.007  1
2005 Sanjabi S, Williams KJ, Saccani S, Zhou L, Hoffmann A, Ghosh G, Gerondakis S, Natoli G, Smale ST. A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. Genes & Development. 19: 2138-51. PMID 16166378 DOI: 10.1101/gad.1329805  0.64
2005 Huang DB, Vu D, Ghosh G. NF-kappaB RelB forms an intertwined homodimer. Structure (London, England : 1993). 13: 1365-73. PMID 16154093 DOI: 10.1016/j.str.2005.06.018  1
2005 Mesika A, Kiss V, Brumfeld V, Ghosh G, Reich Z. Enhanced intracellular mobility and nuclear accumulation of DNA plasmids associated with a karyophilic protein. Human Gene Therapy. 16: 200-8. PMID 15761260 DOI: 10.1089/hum.2005.16.200  1
2005 Huang DB, Phelps CB, Fusco AJ, Ghosh G. Crystal structure of a free kappaB DNA: insights into DNA recognition by transcription factor NF-kappaB. Journal of Molecular Biology. 346: 147-60. PMID 15663934 DOI: 10.1016/j.jmb.2004.11.042  1
2004 Bonizzi G, Bebien M, Otero DC, Johnson-Vroom KE, Cao Y, Vu D, Jegga AG, Aronow BJ, Ghosh G, Rickert RC, Karin M. Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. The Embo Journal. 23: 4202-10. PMID 15470505 DOI: 10.1038/sj.emboj.7600391  1
2004 Nolen B, Taylor S, Ghosh G. Regulation of protein kinases; controlling activity through activation segment conformation. Molecular Cell. 15: 661-75. PMID 15350212 DOI: 10.1016/j.molcel.2004.08.024  1
2004 Croy CH, Bergqvist S, Huxford T, Ghosh G, Komives EA. Biophysical characterization of the free IkappaBalpha ankyrin repeat domain in solution. Protein Science : a Publication of the Protein Society. 13: 1767-77. PMID 15215520 DOI: 10.1110/ps.04731004  1
2004 Aubol BE, Ungs L, Lukasiewicz R, Ghosh G, Adams JA. Chemical clamping allows for efficient phosphorylation of the RNA carrier protein Npl3. The Journal of Biological Chemistry. 279: 30182-8. PMID 15145958 DOI: 10.1074/jbc.M402797200  1
2004 Ghosh G, Huang DB, Huxford T. Molecular mimicry of the NF-kappaB DNA target site by a selected RNA aptamer. Current Opinion in Structural Biology. 14: 21-7. PMID 15102445 DOI: 10.1016/j.sbi.2004.01.004  1
2004 Chen Y, Vallee S, Wu J, Vu D, Sondek J, Ghosh G. Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. Molecular and Cellular Biology. 24: 3048-56. PMID 15024091 DOI: 10.1128/MCB.24.7.3048-3056.2004  1
2004 Phelps CB, Ghosh G. Discreet mutations from c-Rel to v-Rel alter kappaB DNA recognition, IkappaBalpha binding, and dimerization: implications for v-Rel oncogenicity. Oncogene. 23: 1229-38. PMID 14961076 DOI: 10.1038/sj.onc.1207242  1
2003 Aubol BE, Nolen B, Shaffer J, Ghosh G, Adams JA. Novel destabilization of nucleotide binding by the gamma phosphate of ATP in the yeast SR protein kinase Sky1p. Biochemistry. 42: 12813-20. PMID 14596595 DOI: 10.1021/bi035200c  1
2003 Aubol BE, Chakrabarti S, Ngo J, Shaffer J, Nolen B, Fu XD, Ghosh G, Adams JA. Processive phosphorylation of alternative splicing factor/splicing factor 2. Proceedings of the National Academy of Sciences of the United States of America. 100: 12601-6. PMID 14555757 DOI: 10.1073/pnas.1635129100  1
2003 Nolen B, Ngo J, Chakrabarti S, Vu D, Adams JA, Ghosh G. Nucleotide-induced conformational changes in the Saccharomyces cerevisiae SR protein kinase, Sky1p, revealed by X-ray crystallography. Biochemistry. 42: 9575-85. PMID 12911299 DOI: 10.1021/bi0344331  1
2003 Huang DB, Vu D, Cassiday LA, Zimmerman JM, Maher LJ, Ghosh G. Crystal structure of NF-kappaB (p50)2 complexed to a high-affinity RNA aptamer. Proceedings of the National Academy of Sciences of the United States of America. 100: 9268-73. PMID 12886018 DOI: 10.1073/pnas.1632011100  1
2003 Malek S, Huang DB, Huxford T, Ghosh S, Ghosh G. X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex. The Journal of Biological Chemistry. 278: 23094-100. PMID 12686541 DOI: 10.1074/jbc.M301022200  1
2003 Chen Y, Wu J, Ghosh G. KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta x NF-kappaB complexes. The Journal of Biological Chemistry. 278: 23101-6. PMID 12672800 DOI: 10.1074/jbc.M301021200  1
2003 Moorthy AK, Ghosh G. p105.Ikappa Bgamma and prototypical Ikappa Bs use a similar mechanism to bind but a different mechanism to regulate the subcellular localization of NF-kappa B. The Journal of Biological Chemistry. 278: 556-66. PMID 12399470 DOI: 10.1074/jbc.M207515200  1
2002 Huxford T, Mishler D, Phelps CB, Huang DB, Sengchanthalangsy LL, Reeves R, Hughes CA, Komives EA, Ghosh G. Solvent exposed non-contacting amino acids play a critical role in NF-kappaB/IkappaBalpha complex formation. Journal of Molecular Biology. 324: 587-97. PMID 12460563 DOI: 10.1016/S0022-2836(02)01149-X  1
2002 Aubol BE, Nolen B, Vu D, Ghosh G, Adams JA. Mechanistic insights into Sky1p, a yeast homologue of the mammalian SR protein kinases. Biochemistry. 41: 10002-9. PMID 12146964 DOI: 10.1021/bi020233y  1
2002 Chen-Park FE, Huang DB, Noro B, Thanos D, Ghosh G. The kappa B DNA sequence from the HIV long terminal repeat functions as an allosteric regulator of HIV transcription. The Journal of Biological Chemistry. 277: 24701-8. PMID 11970949 DOI: 10.1074/jbc.M200007200  1
2002 Berkowitz B, Huang DB, Chen-Park FE, Sigler PB, Ghosh G. The x-ray crystal structure of the NF-kappa B p50.p65 heterodimer bound to the interferon beta -kappa B site. The Journal of Biological Chemistry. 277: 24694-700. PMID 11970948 DOI: 10.1074/jbc.M200006200  1
2001 Huang DB, Chen YQ, Ruetsche M, Phelps CB, Ghosh G. X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2. Structure (London, England : 1993). 9: 669-78. PMID 11587641 DOI: 10.1016/S0969-2126(01)00635-9  1
2001 Malek S, Chen Y, Huxford T, Ghosh G. IkappaBbeta, but not IkappaBalpha, functions as a classical cytoplasmic inhibitor of NF-kappaB dimers by masking both NF-kappaB nuclear localization sequences in resting cells. The Journal of Biological Chemistry. 276: 45225-35. PMID 11571291 DOI: 10.1074/jbc.M105865200  1
2001 Nolen B, Yun CY, Wong CF, McCammon JA, Fu XD, Ghosh G. The structure of Sky1p reveals a novel mechanism for constitutive activity. Nature Structural Biology. 8: 176-83. PMID 11175909 DOI: 10.1038/84178  1
2000 Huxford T, Malek S, Ghosh G. Preparation and crystallization of dynamic NF-kappa B.Ikappa B complexes. The Journal of Biological Chemistry. 275: 32800-6. PMID 10906335 DOI: 10.1074/jbc.M006037200  1
2000 Phelps CB, Sengchanthalangsy LL, Huxford T, Ghosh G. Mechanism of I kappa B alpha binding to NF-kappa B dimers. The Journal of Biological Chemistry. 275: 29840-6. PMID 10882738 DOI: 10.1074/jbc.M004899200  1
2000 Phelps CB, Sengchanthalangsy LL, Malek S, Ghosh G. Mechanism of kappa B DNA binding by Rel/NF-kappa B dimers. The Journal of Biological Chemistry. 275: 24392-9. PMID 10825175 DOI: 10.1074/jbc.M003784200  1
2000 Chen YQ, Sengchanthalangsy LL, Hackett A, Ghosh G. NF-kappaB p65 (RelA) homodimer uses distinct mechanisms to recognize DNA targets. Structure (London, England : 1993). 8: 419-28. PMID 10801482 DOI: 10.1016/S0969-2126(00)00123-4  1
2000 Straus DS, Pascual G, Li M, Welch JS, Ricote M, Hsiang CH, Sengchanthalangsy LL, Ghosh G, Glass CK. 15-deoxy-delta 12,14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway. Proceedings of the National Academy of Sciences of the United States of America. 97: 4844-9. PMID 10781090 DOI: 10.1073/pnas.97.9.4844  1
1999 Huxford T, Malek S, Ghosh G. Structure and mechanism in NF-kappa B/I kappa B signaling. Cold Spring Harbor Symposia On Quantitative Biology. 64: 533-40. PMID 11232330  1
1999 Chen FE, Ghosh G. Regulation of DNA binding by Rel/NF-kappaB transcription factors: structural views. Oncogene. 18: 6845-52. PMID 10602460 DOI: 10.1038/sj.onc.1203224  1
1999 Sengchanthalangsy LL, Datta S, Huang DB, Anderson E, Braswell EH, Ghosh G. Characterization of the dimer interface of transcription factor NFkappaB p50 homodimer. Journal of Molecular Biology. 289: 1029-40. PMID 10369780 DOI: 10.1006/jmbi.1999.2823  1
1999 Chen FE, Kempiak S, Huang DB, Phelps C, Ghosh G. Construction, expression, purification and functional analysis of recombinant NFkappaB p50/p65 heterodimer. Protein Engineering. 12: 423-8. PMID 10360983  1
1998 Huxford T, Huang DB, Malek S, Ghosh G. The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation. Cell. 95: 759-70. PMID 9865694 DOI: 10.1016/S0092-8674(00)81699-2  1
1998 Malek S, Huxford T, Ghosh G. Ikappa Balpha functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-kappaB. The Journal of Biological Chemistry. 273: 25427-35. PMID 9738011 DOI: 10.1074/jbc.273.39.25427  1
1998 Chen FE, Huang DB, Chen YQ, Ghosh G. Crystal structure of p50/p65 heterodimer of transcription factor NF-kappaB bound to DNA. Nature. 391: 410-3. PMID 9450761 DOI: 10.1038/34956  1
1998 Chen YQ, Ghosh S, Ghosh G. A novel DNA recognition mode by the NF-kappa B p65 homodimer. Nature Structural Biology. 5: 67-73. PMID 9437432 DOI: 10.1038/nsb0198-67  1
1997 Huang DB, Huxford T, Chen YQ, Ghosh G. The role of DNA in the mechanism of NFkappaB dimer formation: crystal structures of the dimerization domains of the p50 and p65 subunits. Structure (London, England : 1993). 5: 1427-36. PMID 9384558  1
1997 Kosa PF, Ghosh G, DeDecker BS, Sigler PB. The 2.1-A crystal structure of an archaeal preinitiation complex: TATA-box-binding protein/transcription factor (II)B core/TATA-box. Proceedings of the National Academy of Sciences of the United States of America. 94: 6042-7. PMID 9177165 DOI: 10.1073/pnas.94.12.6042  0.56
1996 Ghosh G, Van Duyne GD. Pieces of the puzzle: assembling the preinitiation complex of Pol II. Structure (London, England : 1993). 4: 891-5. PMID 8805573 DOI: 10.1016/S0969-2126(96)00096-2  1
1996 Van Duyne GD, Ghosh G, Maas WK, Sigler PB. Structure of the oligomerization and L-arginine binding domain of the arginine repressor of Escherichia coli. Journal of Molecular Biology. 256: 377-91. PMID 8594204 DOI: 10.1006/jmbi.1996.0093  1
1995 Ghosh G, van Duyne G, Ghosh S, Sigler PB. Structure of NF-kappa B p50 homodimer bound to a kappa B site. Nature. 373: 303-10. PMID 7530332 DOI: 10.1038/373303a0  1
1993 Kim HY, Ghosh G, Schulman LH, Brunie S, Jakubowski H. The relationship between synthetic and editing functions of the active site of an aminoacyl-tRNA synthetase. Proceedings of the National Academy of Sciences of the United States of America. 90: 11553-7. PMID 8265588  1
1991 Ghosh G, Pelka H, Schulman LH, Brunie S. Activation of methionine by Escherichia coli methionyl-tRNA synthetase. Biochemistry. 30: 9569-75. PMID 1911742  0.68
1991 Ghosh G, Kim HY, Demaret JP, Brunie S, Schulman LH. Arginine-395 is required for efficient in vivo and in vitro aminoacylation of tRNAs by Escherichia coli methionyl-tRNA synthetase. Biochemistry. 30: 11767-74. PMID 1751493  0.32
1991 Ghosh G, Brunie S, Schulman LH. Transition state stabilization by a phylogenetically conserved tyrosine residue in methionyl-tRNA synthetase. The Journal of Biological Chemistry. 266: 17136-41. PMID 1654323  1
1990 Ghosh G, Pelka H, Schulman LH. Identification of the tRNA anticodon recognition site of Escherichia coli methionyl-tRNA synthetase. Biochemistry. 29: 2220-5. PMID 2186810  1
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