Paul B. Sigler - Publications

Affiliations: 
Yale University, New Haven, CT 
Area:
regulation of gene expression mediated by proteins that bind specifically to DNA, signal transduction pathway involved in vision, structural biology
Website:
http://www.csb.yale.edu/people/sigler/index.html

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2008 Slep KC, Kercher MA, Wieland T, Chen CK, Simon MI, Sigler PB. Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation. Proceedings of the National Academy of Sciences of the United States of America. 105: 6243-8. PMID 18434540 DOI: 10.1073/Pnas.0801569105  0.407
2003 Lee S, Sowa ME, Watanabe YH, Sigler PB, Chiu W, Yoshida M, Tsai FT. The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state. Cell. 115: 229-40. PMID 14567920 DOI: 10.1016/S0092-8674(03)00807-9  0.341
2003 Chaudhry C, Farr GW, Todd MJ, Rye HS, Brunger AT, Adams PD, Horwich AL, Sigler PB. Role of the gamma-phosphate of ATP in triggering protein folding by GroEL-GroES: function, structure and energetics. The Embo Journal. 22: 4877-87. PMID 14517228 DOI: 10.1093/Emboj/Cdg477  0.763
2002 Berkowitz B, Huang DB, Chen-Park FE, Sigler PB, Ghosh G. The x-ray crystal structure of the NF-kappa B p50.p65 heterodimer bound to the interferon beta -kappa B site. The Journal of Biological Chemistry. 277: 24694-700. PMID 11970948 DOI: 10.1074/Jbc.M200006200  0.657
2001 Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, Sigler PB. Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A. Nature. 409: 1071-7. PMID 11234020 DOI: 10.1038/35059138  0.431
2000 Ma J, Sigler PB, Xu Z, Karplus M. A dynamic model for the allosteric mechanism of GroEL. Journal of Molecular Biology. 302: 303-13. PMID 10970735 DOI: 10.1006/Jmbi.2000.4014  0.507
2000 Tsai FT, Sigler PB. Structural basis of preinitiation complex assembly on human pol II promoters. The Embo Journal. 19: 25-36. PMID 10619841 DOI: 10.1093/Emboj/19.1.25  0.425
1999 Bell SD, Kosa PL, Sigler PB, Jackson SP. Orientation of the transcription preinitiation complex in archaea. Proceedings of the National Academy of Sciences of the United States of America. 96: 13662-7. PMID 10570129 DOI: 10.1073/Pnas.96.24.13662  0.325
1999 Schubert C, Hirsch JA, Gurevich VV, Engelman DM, Sigler PB, Fleming KG. Visual arrestin activity may be regulated by self-association. The Journal of Biological Chemistry. 274: 21186-90. PMID 10409673 DOI: 10.1074/Jbc.274.30.21186  0.673
1999 Gaudet R, Savage JR, McLaughlin JN, Willardson BM, Sigler PB. A molecular mechanism for the phosphorylation-dependent regulation of heterotrimeric G proteins by phosducin. Molecular Cell. 3: 649-60. PMID 10360181 DOI: 10.1016/S1097-2765(00)80358-5  0.582
1999 Hirsch JA, Schubert C, Gurevich VV, Sigler PB. The 2.8 A crystal structure of visual arrestin: a model for arrestin's regulation. Cell. 97: 257-69. PMID 10219246 DOI: 10.1016/S0092-8674(00)80735-7  0.675
1999 Vishnivetskiy SA, Paz CL, Schubert C, Hirsch JA, Sigler PB, Gurevich VV. How does arrestin respond to the phosphorylated state of rhodopsin? The Journal of Biological Chemistry. 274: 11451-4. PMID 10206946 DOI: 10.1074/Jbc.274.17.11451  0.698
1998 Xu Z, Sigler PB. GroEL/GroES: structure and function of a two-stroke folding machine. Journal of Structural Biology. 124: 129-41. PMID 10049801 DOI: 10.1006/Jsbi.1998.4060  0.558
1998 Sigler PB, Xu Z, Rye HS, Burston SG, Fenton WA, Horwich AL. Structure and function in GroEL-mediated protein folding. Annual Review of Biochemistry. 67: 581-608. PMID 9759498 DOI: 10.1146/Annurev.Biochem.67.1.581  0.516
1997 Cox JM, Hayward MM, Sanchez JF, Gegnas LD, van der Zee S, Dennis JH, Sigler PB, Schepartz A. Bidirectional binding of the TATA box binding protein to the TATA box. Proceedings of the National Academy of Sciences of the United States of America. 94: 13475-80. PMID 9391050 DOI: 10.1073/Pnas.94.25.13475  0.638
1997 Rye HS, Burston SG, Fenton WA, Beechem JM, Xu Z, Sigler PB, Horwich AL. Distinct actions of cis and trans ATP within the double ring of the chaperonin GroEL. Nature. 388: 792-8. PMID 9285593 DOI: 10.1038/42047  0.477
1997 Xu Z, Horwich AL, Sigler PB. The crystal structure of the asymmetric GroEL-GroES-(ADP)7 chaperonin complex. Nature. 388: 741-50. PMID 9285585 DOI: 10.1038/41944  0.581
1997 Bohm A, Gaudet R, Sigler PB. Structural aspects of heterotrimeric G-protein signaling. Current Opinion in Biotechnology. 8: 480-7. PMID 9265729 DOI: 10.1016/S0958-1669(97)80072-9  0.627
1997 Wang Y, Jiang Y, Meyering-Voss M, Sprinzl M, Sigler PB. Crystal structure of the EF-Tu.EF-Ts complex from Thermus thermophilus. Nature Structural Biology. 4: 650-6. PMID 9253415 DOI: 10.1038/Nsb0897-650  0.681
1997 Kosa PF, Ghosh G, DeDecker BS, Sigler PB. The 2.1-A crystal structure of an archaeal preinitiation complex: TATA-box-binding protein/transcription factor (II)B core/TATA-box. Proceedings of the National Academy of Sciences of the United States of America. 94: 6042-7. PMID 9177165 DOI: 10.1073/Pnas.94.12.6042  0.587
1997 Han SK, Yoon ET, Scott DL, Sigler PB, Cho W. Structural aspects of interfacial adsorption. A crystallographic and site-directed mutagenesis study of the phospholipase A2 from the venom of Agkistrodon piscivorus piscivorus. The Journal of Biological Chemistry. 272: 3573-82. PMID 9013608 DOI: 10.1074/Jbc.272.6.3573  0.355
1996 DeDecker BS, O'Brien R, Fleming PJ, Geiger JH, Jackson SP, Sigler PB. The crystal structure of a hyperthermophilic archaeal TATA-box binding protein. Journal of Molecular Biology. 264: 1072-84. PMID 9000631 DOI: 10.1006/jmbi.1996.0697  0.651
1996 Gaudet R, Bohm A, Sigler PB. Crystal structure at 2.4 angstroms resolution of the complex of transducin betagamma and its regulator, phosducin. Cell. 87: 577-88. PMID 8898209 DOI: 10.1016/S0092-8674(00)81376-8  0.675
1996 Jiang Y, Nock S, Nesper M, Sprinzl M, Sigler PB. Structure and importance of the dimerization domain in elongation factor Ts from Thermus thermophilus. Biochemistry. 35: 10269-78. PMID 8756682 DOI: 10.1021/Bi960918W  0.665
1996 Geiger JH, Hahn S, Lee S, Sigler PB. Crystal structure of the yeast TFIIA/TBP/DNA complex. Science (New York, N.Y.). 272: 830-6. PMID 8629014 DOI: 10.1126/Science.272.5263.830  0.687
1996 Van Duyne GD, Ghosh G, Maas WK, Sigler PB. Structure of the oligomerization and L-arginine binding domain of the arginine repressor of Escherichia coli. Journal of Molecular Biology. 256: 377-91. PMID 8594204 DOI: 10.1006/jmbi.1996.0093  0.58
1996 Boisvert DC, Wang J, Otwinowski Z, Horwich AL, Sigler PB. The 2.4 A crystal structure of the bacterial chaperonin GroEL complexed with ATP gamma S. Nature Structural Biology. 3: 170-7. PMID 8564544 DOI: 10.1038/Nsb0296-170  0.37
1996 Sondek J, Bohm A, Lambright DG, Hamm HE, Sigler PB. Crystal structure of a G-protein beta gamma dimer at 2.1A resolution. Nature. 379: 369-74. PMID 8552196 DOI: 10.1038/379369A0  0.367
1996 Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, Sigler PB. The 2.0 A crystal structure of a heterotrimeric G protein. Nature. 379: 311-9. PMID 8552184 DOI: 10.1038/379311A0  0.415
1996 Geiger JH, Hahn S, Sigler PB. Structural analysis of the TBP/TFIIA/TATA complex Acta Crystallographica Section a Foundations of Crystallography. 52: C154-C154. DOI: 10.1107/S0108767396093087  0.589
1996 Sondeck J, Bohm A, Lambright DG, Skiba NP, Noel JP, Hamm HE, Sigler PB. Refined structures of heterotrimeric G protein complexes at high resolution Acta Crystallographica Section a Foundations of Crystallography. 52: C184-C185. DOI: 10.1107/S0108767396091921  0.529
1996 Jiang Y, Nock S, Nesper M, Sprinzl M, Sigler PB. Structure and importance of the dimerization domain in elongation factor Ts fromThermos thermophillus Acta Crystallographica Section a Foundations of Crystallography. 52: C187-C187. DOI: 10.1107/S0108767396091829  0.634
1996 Sondek J, Bohm A, Lambright DG, Hamm HE, Sigler PB. Erratum: Crystal structure of a G-protein βγ dimer at 2.1 Å resolution Nature. 379: 847-847. DOI: 10.1038/379847A0  0.355
1995 Ferguson KM, Lemmon MA, Schlessinger J, Sigler PB. Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain. Cell. 83: 1037-46. PMID 8521504 DOI: 10.1016/0092-8674(95)90219-8  0.635
1995 Rastinejad F, Perlmann T, Evans RM, Sigler PB. Structural determinants of nuclear receptor assembly on DNA direct repeats. Nature. 375: 203-11. PMID 7746322 DOI: 10.1038/375203A0  0.403
1995 Gewirth DT, Sigler PB. The basis for half-site specificity explored through a non-cognate steroid receptor-DNA complex. Nature Structural Biology. 2: 386-94. PMID 7664096 DOI: 10.1038/Nsb0595-386  0.367
1995 Ferguson KM, Lemmon MA, Sigler PB, Schlessinger J. Scratching the surface with the PH domain. Nature Structural Biology. 2: 715-8. PMID 7552736 DOI: 10.1038/Nsb0995-715  0.612
1995 Ghosh G, van Duyne G, Ghosh S, Sigler PB. Structure of NF-kappa B p50 homodimer bound to a kappa B site. Nature. 373: 303-10. PMID 7530332 DOI: 10.1038/373303A0  0.558
1995 Lemmon MA, Ferguson KM, O'Brien R, Sigler PB, Schlessinger J. Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain. Proceedings of the National Academy of Sciences of the United States of America. 92: 10472-6. PMID 7479822 DOI: 10.1073/Pnas.92.23.10472  0.613
1994 Lambright DG, Noel JP, Hamm HE, Sigler PB. Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein. Nature. 369: 621-8. PMID 8208289 DOI: 10.1038/369621A0  0.609
1994 Shakked Z, Guzikevich-Guerstein G, Frolow F, Rabinovich D, Joachimiak A, Sigler PB. Determinants of repressor/operator recognition from the structure of the trp operator binding site. Nature. 368: 469-73. PMID 8133895 DOI: 10.1038/368469A0  0.455
1994 Sondek J, Lambright DG, Noel JP, Hamm HE, Sigler PB. GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4. Nature. 372: 276-9. PMID 7969474 DOI: 10.1038/372276A0  0.592
1994 Ferguson KM, Lemmon MA, Schlessinger J, Sigler PB. Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin. Cell. 79: 199-209. PMID 7954789 DOI: 10.1016/0092-8674(94)90190-2  0.601
1993 Kim Y, Geiger JH, Hahn S, Sigler PB. Crystal structure of a yeast TBP/TATA-box complex. Nature. 365: 512-20. PMID 8413604 DOI: 10.1038/365512A0  0.672
1993 Noel JP, Hamm HE, Sigler PB. The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S. Nature. 366: 654-63. PMID 8259210 DOI: 10.1038/366654A0  0.65
1992 Hegde RS, Grossman SR, Laimins LA, Sigler PB. Crystal structure at 1.7 A of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target. Nature. 359: 505-12. PMID 1328886 DOI: 10.1038/359505A0  0.398
1991 Marmorstein RQ, Sprinzl M, Sigler PB. An alkaline phosphatase protection assay to investigate trp repressor/operator interactions. Biochemistry. 30: 1141-8. PMID 1989682  0.548
1991 Luisi BF, Xu WX, Otwinowski Z, Freedman LP, Yamamoto KR, Sigler PB. Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature. 352: 497-505. PMID 1865905 DOI: 10.1038/352497A0  0.586
1990 Luisi BF, Sigler PB. The stereochemistry and biochemistry of the trp repressor-operator complex. Biochimica Et Biophysica Acta. 1048: 113-26. PMID 2182120 DOI: 10.1016/0167-4781(90)90047-6  0.498
1989 Marmorstein RQ, Sigler PB. Stereochemical effects of L-tryptophan and its analogues on trp repressor's affinity for operator-DNA. The Journal of Biological Chemistry. 264: 9149-54. PMID 2656696  0.565
1988 Otwinowski Z, Schevitz RW, Zhang RG, Lawson CL, Joachimiak A, Marmorstein RQ, Luisi BF, Sigler PB. Crystal structure of trp repressor/operator complex at atomic resolution. Nature. 335: 321-9. PMID 3419502 DOI: 10.1038/335321a0  0.752
1988 Freedman LP, Yamamoto KR, Luisi BF, Sigler PB. More fingers in hand. Cell. 54: 444. PMID 3401923 DOI: 10.1016/0092-8674(88)90063-3  0.428
1988 Lawson CL, Zhang RG, Schevitz RW, Otwinowski Z, Joachimiak A, Sigler PB. Flexibility of the DNA-binding domains of trp repressor. Proteins. 3: 18-31. PMID 3375234 DOI: 10.1002/Prot.340030103  0.684
1988 Lawson CL, Sigler PB. The structure of trp pseudorepressor at 1.65A shows why indole propionate acts as a trp 'inducer'. Nature. 333: 869-71. PMID 3290685 DOI: 10.1038/333869A0  0.664
1988 Freedman LP, Luisi BF, Korszun ZR, Basavappa R, Sigler PB, Yamamoto KR. The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain. Nature. 334: 543-6. PMID 3043231 DOI: 10.1038/334543A0  0.589
1987 Zhang RG, Joachimiak A, Lawson CL, Schevitz RW, Otwinowski Z, Sigler PB. The crystal structure of trp aporepressor at 1.8 A shows how binding tryptophan enhances DNA affinity. Nature. 327: 591-7. PMID 3600756 DOI: 10.1038/327591A0  0.695
1987 Marmorstein RQ, Joachimiak A, Sprinzl M, Sigler PB. The structural basis for the interaction between L-tryptophan and the Escherichia coli trp aporepressor. The Journal of Biological Chemistry. 262: 4922-7. PMID 3549712  0.535
1987 Joachimiak A, Marmorstein RQ, Schevitz RW, Mandecki W, Fox JL, Sigler PB. Crystals of the trp repressor-operator complex suitable for X-ray diffraction analysis. The Journal of Biological Chemistry. 262: 4917-21. PMID 3549711  0.559
1987 Schevitz RW, Joachimiak A, Zhang R, Lawson CL, Marmorstein RQ, Otwinowski Z, Sigler PB. Thetrprepressor/operator system: the crystallography of ligand-activated genetic regulation Acta Crystallographica Section a Foundations of Crystallography. 43: C16-C16. DOI: 10.1107/S0108767387085118  0.661
1985 Renetseder R, Brunie S, Dijkstra BW, Drenth J, Sigler PB. A comparison of the crystal structures of phospholipase A2 from bovine pancreas and Crotalus atrox venom. The Journal of Biological Chemistry. 260: 11627-34. PMID 4044572  0.314
1985 Schevitz RW, Otwinowski Z, Joachimiak A, Lawson CL, Sigler PB. The three-dimensional structure of trp repressor. Nature. 317: 782-6. PMID 3903514 DOI: 10.1038/317782A0  0.698
1981 Keith C, Feldman DS, Deganello S, Glick J, Ward KB, Jones EO, Sigler PB. The 2.5 A crystal structure of a dimeric phospholipase A2 from the venom of Crotalus atrox. The Journal of Biological Chemistry. 256: 8602-7. PMID 7263673  0.708
1968 Sigler PB, Blow DM, Matthews BW, Henderson R. Structure of crystalline -chymotrypsin. II. A preliminary report including a hypothesis for the activation mechanism. Journal of Molecular Biology. 35: 143-64. PMID 5760561 DOI: 10.1016/S0022-2836(68)80043-9  0.696
1967 Matthews BW, Sigler PB, Henderson R, Blow DM. Three-dimensional structure of tosyl-alpha-chymotrypsin. Nature. 214: 652-6. PMID 6049071 DOI: 10.1038/214652A0  0.704
1966 Sigler PB, Jeffery BA, Matthews BW, Blow DM. An x-ray diffraction study of inhibited derivatives of alpha-chymotrypsin. Journal of Molecular Biology. 15: 175-92. PMID 5912039 DOI: 10.1016/S0022-2836(66)80219-X  0.614
1965 Sigler PB, Blow DM. A means of promoting heavy-atom binding in protein crystals. Journal of Molecular Biology. 14: 640-4. PMID 5880874  0.598
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