Paul B. Sigler - Publications

Affiliations: 
Yale University, New Haven, CT 
Area:
regulation of gene expression mediated by proteins that bind specifically to DNA, signal transduction pathway involved in vision, structural biology
Website:
http://www.csb.yale.edu/people/sigler/index.html

152 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2009 Korkhin Y, Unligil UM, Littlefield O, Nelson PJ, Stuart DI, Sigler PB, Bell SD, Abrescia NG. Evolution of complex RNA polymerases: the complete archaeal RNA polymerase structure. Plos Biology. 7: e1000102. PMID 19419240 DOI: 10.1371/journal.pbio.1000102  1
2008 Slep KC, Kercher MA, Wieland T, Chen CK, Simon MI, Sigler PB. Molecular architecture of Galphao and the structural basis for RGS16-mediated deactivation. Proceedings of the National Academy of Sciences of the United States of America. 105: 6243-8. PMID 18434540 DOI: 10.1073/pnas.0801569105  1
2003 Lee S, Sowa ME, Watanabe YH, Sigler PB, Chiu W, Yoshida M, Tsai FT. The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state. Cell. 115: 229-40. PMID 14567920 DOI: 10.1016/S0092-8674(03)00807-9  1
2003 Chaudhry C, Farr GW, Todd MJ, Rye HS, Brunger AT, Adams PD, Horwich AL, Sigler PB. Role of the gamma-phosphate of ATP in triggering protein folding by GroEL-GroES: function, structure and energetics. The Embo Journal. 22: 4877-87. PMID 14517228 DOI: 10.1093/emboj/cdg477  1
2003 Juo ZS, Kassavetis GA, Wang J, Geiduschek EP, Sigler PB. Crystal structure of a transcription factor IIIB core interface ternary complex. Nature. 422: 534-9. PMID 12660736 DOI: 10.1038/nature01534  1
2002 Berkowitz B, Huang DB, Chen-Park FE, Sigler PB, Ghosh G. The x-ray crystal structure of the NF-kappa B p50.p65 heterodimer bound to the interferon beta -kappa B site. The Journal of Biological Chemistry. 277: 24694-700. PMID 11970948 DOI: 10.1074/jbc.M200006200  1
2001 Han M, Gurevich VV, Vishnivetskiy SA, Sigler PB, Schubert C. Crystal structure of beta-arrestin at 1.9 A: possible mechanism of receptor binding and membrane Translocation. Structure (London, England : 1993). 9: 869-80. PMID 11566136 DOI: 10.1016/S0969-2126(01)00644-X  1
2001 Korkhin Y, Littlefield O, Nelson PJ, Bell SD, Sigler PB. Preparation of components of archaeal transcription preinitiation complex. Methods in Enzymology. 334: 227-39. PMID 11398464 DOI: 10.1016/S0076-6879(01)34471-3  1
2001 Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, Sigler PB. Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A. Nature. 409: 1071-7. PMID 11234020 DOI: 10.1038/35059138  1
2000 Sigler PB, Stein GS, Boskey AL, Jones ND, Kuriyan J, Miller WM, Shuler ML, Wang BC. Cell science and protein crystal growth research for the International Space Station. Journal of Cellular Biochemistry. 79: 662-71. PMID 10996856 DOI: 10.1002/1097-4644(20001215)79:4<662::AID-JCB140>3.0.CO;2-4  1
2000 Ma J, Sigler PB, Xu Z, Karplus M. A dynamic model for the allosteric mechanism of GroEL. Journal of Molecular Biology. 302: 303-13. PMID 10970735 DOI: 10.1006/jmbi.2000.4014  1
2000 Geller DS, Farhi A, Pinkerton N, Fradley M, Moritz M, Spitzer A, Meinke G, Tsai FT, Sigler PB, Lifton RP. Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy. Science (New York, N.Y.). 289: 119-23. PMID 10884226 DOI: 10.1126/science.289.5476.119  1
2000 Tsai FT, Sigler PB. Structural basis of preinitiation complex assembly on human pol II promoters. The Embo Journal. 19: 25-36. PMID 10619841 DOI: 10.1093/emboj/19.1.25  1
1999 Chen L, Sigler PB. The crystal structure of a GroEL/peptide complex: plasticity as a basis for substrate diversity. Cell. 99: 757-68. PMID 10619429  1
1999 Littlefield O, Korkhin Y, Sigler PB. The structural basis for the oriented assembly of a TBP/TFB/promoter complex. Proceedings of the National Academy of Sciences of the United States of America. 96: 13668-73. PMID 10570130 DOI: 10.1073/pnas.96.24.13668  1
1999 Bell SD, Kosa PL, Sigler PB, Jackson SP. Orientation of the transcription preinitiation complex in archaea. Proceedings of the National Academy of Sciences of the United States of America. 96: 13662-7. PMID 10570129 DOI: 10.1073/pnas.96.24.13662  1
1999 Schubert C, Hirsch JA, Gurevich VV, Engelman DM, Sigler PB, Fleming KG. Visual arrestin activity may be regulated by self-association. The Journal of Biological Chemistry. 274: 21186-90. PMID 10409673 DOI: 10.1074/jbc.274.30.21186  1
1999 Gaudet R, Savage JR, McLaughlin JN, Willardson BM, Sigler PB. A molecular mechanism for the phosphorylation-dependent regulation of heterotrimeric G proteins by phosducin. Molecular Cell. 3: 649-60. PMID 10360181 DOI: 10.1016/S1097-2765(00)80358-5  1
1999 Meinke G, Sigler PB. DNA-binding mechanism of the monomeric orphan nuclear receptor NGFI-B. Nature Structural Biology. 6: 471-7. PMID 10331876 DOI: 10.1038/8276  1
1999 Hirsch JA, Schubert C, Gurevich VV, Sigler PB. The 2.8 A crystal structure of visual arrestin: a model for arrestin's regulation. Cell. 97: 257-69. PMID 10219246  1
1999 Vishnivetskiy SA, Paz CL, Schubert C, Hirsch JA, Sigler PB, Gurevich VV. How does arrestin respond to the phosphorylated state of rhodopsin? The Journal of Biological Chemistry. 274: 11451-4. PMID 10206946 DOI: 10.1074/jbc.274.17.11451  1
1998 Tsai FT, Littlefield O, Kosa PF, Cox JM, Schepartz A, Sigler PB. Polarity of transcription on Pol II and archaeal promoters: where is the "one-way sign" and how is it read? Cold Spring Harbor Symposia On Quantitative Biology. 63: 53-61. PMID 10384270  1
1998 Xu Z, Sigler PB. GroEL/GroES: structure and function of a two-stroke folding machine. Journal of Structural Biology. 124: 129-41. PMID 10049801 DOI: 10.1006/jsbi.1998.4060  1
1998 Sigler PB, Xu Z, Rye HS, Burston SG, Fenton WA, Horwich AL. Structure and function in GroEL-mediated protein folding. Annual Review of Biochemistry. 67: 581-608. PMID 9759498 DOI: 10.1146/annurev.biochem.67.1.581  1
1998 O'Brien R, DeDecker B, Fleming KG, Sigler PB, Ladbury JE. The effects of salt on the TATA binding protein-DNA interaction from a hyperthermophilic archaeon. Journal of Molecular Biology. 279: 117-25. PMID 9636704 DOI: 10.1006/jmbi.1998.1743  1
1998 Williams SP, Sigler PB. Atomic structure of progesterone complexed with its receptor. Nature. 393: 392-6. PMID 9620806 DOI: 10.1038/30775  1
1998 Tanenbaum DM, Wang Y, Williams SP, Sigler PB. Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains. Proceedings of the National Academy of Sciences of the United States of America. 95: 5998-6003. PMID 9600906 DOI: 10.1073/pnas.95.11.5998  1
1998 Apanovitch DM, Slep KC, Sigler PB, Dohlman HG. Sst2 is a GTPase-activating protein for Gpa1: purification and characterization of a cognate RGS-Galpha protein pair in yeast. Biochemistry. 37: 4815-22. PMID 9537998 DOI: 10.1021/bi9729965  1
1998 Sigler PB. Trimeric g-proteins: structure, mechanism and regulation Faseb Journal. 12: A1305.  1
1997 Cox JM, Hayward MM, Sanchez JF, Gegnas LD, van der Zee S, Dennis JH, Sigler PB, Schepartz A. Bidirectional binding of the TATA box binding protein to the TATA box. Proceedings of the National Academy of Sciences of the United States of America. 94: 13475-80. PMID 9391050 DOI: 10.1073/pnas.94.25.13475  1
1997 Rye HS, Burston SG, Fenton WA, Beechem JM, Xu Z, Sigler PB, Horwich AL. Distinct actions of cis and trans ATP within the double ring of the chaperonin GroEL. Nature. 388: 792-8. PMID 9285593 DOI: 10.1038/42047  1
1997 Xu Z, Horwich AL, Sigler PB. The crystal structure of the asymmetric GroEL-GroES-(ADP)7 chaperonin complex. Nature. 388: 741-50. PMID 9285585 DOI: 10.1038/41944  1
1997 Bohm A, Gaudet R, Sigler PB. Structural aspects of heterotrimeric G-protein signaling. Current Opinion in Biotechnology. 8: 480-7. PMID 9265729 DOI: 10.1016/S0958-1669(97)80072-9  1
1997 Wang Y, Jiang Y, Meyering-Voss M, Sprinzl M, Sigler PB. Crystal structure of the EF-Tu.EF-Ts complex from Thermus thermophilus. Nature Structural Biology. 4: 650-6. PMID 9253415 DOI: 10.1038/nsb0897-650  1
1997 Kosa PF, Ghosh G, DeDecker BS, Sigler PB. The 2.1-A crystal structure of an archaeal preinitiation complex: TATA-box-binding protein/transcription factor (II)B core/TATA-box. Proceedings of the National Academy of Sciences of the United States of America. 94: 6042-7. PMID 9177165 DOI: 10.1073/pnas.94.12.6042  1
1997 Han SK, Yoon ET, Scott DL, Sigler PB, Cho W. Structural aspects of interfacial adsorption. A crystallographic and site-directed mutagenesis study of the phospholipase A2 from the venom of Agkistrodon piscivorus piscivorus. The Journal of Biological Chemistry. 272: 3573-82. PMID 9013608 DOI: 10.1074/jbc.272.6.3573  1
1997 Xu Z, Horwich AL, Sigler PB. ATP and the editing of protein folding Faseb Journal. 11: A853.  1
1997 Apanovitch PM, Slep K, Sigler PB, Dohlman HG. Purification and characterization of SST2: Regulation of the gtpase activity of a G protein (GPA1) from the yeast saccharomyces cerevisiae Faseb Journal. 11: A1304.  1
1997 Skiba N, Bae H, Ford C, Daaka Y, Reuvenv E, Shekter L, Van Biesen T, Yang CS, Lambright D, Sondek J, Sigler P, Miller R, Jan L, Lefkowitz R, Hamm H. Molecular basis for gβγ-effector interaction: Structural correlation with ga binding site Faseb Journal. 11: A1340.  1
1996 DeDecker BS, O'Brien R, Fleming PJ, Geiger JH, Jackson SP, Sigler PB. The crystal structure of a hyperthermophilic archaeal TATA-box binding protein. Journal of Molecular Biology. 264: 1072-84. PMID 9000631 DOI: 10.1006/jmbi.1996.0697  1
1996 Gaudet R, Bohm A, Sigler PB. Crystal structure at 2.4 angstroms resolution of the complex of transducin betagamma and its regulator, phosducin. Cell. 87: 577-88. PMID 8898209 DOI: 10.1016/S0092-8674(00)81376-8  1
1996 Jiang Y, Nock S, Nesper M, Sprinzl M, Sigler PB. Structure and importance of the dimerization domain in elongation factor Ts from Thermus thermophilus. Biochemistry. 35: 10269-78. PMID 8756682 DOI: 10.1021/bi960918w  1
1996 Geiger JH, Hahn S, Lee S, Sigler PB. Crystal structure of the yeast TFIIA/TBP/DNA complex. Science (New York, N.Y.). 272: 830-6. PMID 8629014  1
1996 Van Duyne GD, Ghosh G, Maas WK, Sigler PB. Structure of the oligomerization and L-arginine binding domain of the arginine repressor of Escherichia coli. Journal of Molecular Biology. 256: 377-91. PMID 8594204 DOI: 10.1006/jmbi.1996.0093  1
1996 Boisvert DC, Wang J, Otwinowski Z, Horwich AL, Sigler PB. The 2.4 A crystal structure of the bacterial chaperonin GroEL complexed with ATP gamma S. Nature Structural Biology. 3: 170-7. PMID 8564544  1
1996 Sondek J, Bohm A, Lambright DG, Hamm HE, Sigler PB. Crystal structure of a G-protein beta gamma dimer at 2.1A resolution. Nature. 379: 369-74. PMID 8552196 DOI: 10.1038/379369a0  0.6
1996 Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, Sigler PB. The 2.0 A crystal structure of a heterotrimeric G protein. Nature. 379: 311-9. PMID 8552184 DOI: 10.1038/379311a0  1
1996 Sigler PB. Space and curvature as specificity determinants in the dna targets of transcription factors Faseb Journal. 10: A1135.  1
1995 Kwong PD, McDonald NQ, Sigler PB, Hendrickson WA. Structure of beta 2-bungarotoxin: potassium channel binding by Kunitz modules and targeted phospholipase action. Structure (London, England : 1993). 3: 1109-19. PMID 8590005 DOI: 10.1016/S0969-2126(01)00246-5  1
1995 Ferguson KM, Lemmon MA, Schlessinger J, Sigler PB. Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain. Cell. 83: 1037-46. PMID 8521504 DOI: 10.1016/0092-8674(95)90219-8  1
1995 Sigler PB, Horwich AL. Unliganded GroEL at 2.8 A: structure and functional implications. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 348: 113-9. PMID 7770481 DOI: 10.1098/rstb.1995.0052  1
1995 Rastinejad F, Perlmann T, Evans RM, Sigler PB. Structural determinants of nuclear receptor assembly on DNA direct repeats. Nature. 375: 203-11. PMID 7746322 DOI: 10.1038/375203a0  1
1995 Weissman JS, Sigler PB, Horwich AL. From the cradle to the grave: ring complexes in the life of a protein. Science (New York, N.Y.). 268: 523-4. PMID 7725096  1
1995 Gewirth DT, Sigler PB. The basis for half-site specificity explored through a non-cognate steroid receptor-DNA complex. Nature Structural Biology. 2: 386-94. PMID 7664096  1
1995 Ferguson KM, Lemmon MA, Sigler PB, Schlessinger J. Scratching the surface with the PH domain. Nature Structural Biology. 2: 715-8. PMID 7552736 DOI: 10.1038/nsb0995-715  1
1995 Ghosh G, van Duyne G, Ghosh S, Sigler PB. Structure of NF-kappa B p50 homodimer bound to a kappa B site. Nature. 373: 303-10. PMID 7530332 DOI: 10.1038/373303a0  1
1995 Lemmon MA, Ferguson KM, O'Brien R, Sigler PB, Schlessinger J. Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain. Proceedings of the National Academy of Sciences of the United States of America. 92: 10472-6. PMID 7479822 DOI: 10.1073/pnas.92.23.10472  1
1994 Joachimiak A, Haran TE, Sigler PB. Mutagenesis supports water mediated recognition in the trp repressor-operator system. The Embo Journal. 13: 367-72. PMID 8313881  1
1994 Lambright DG, Noel JP, Hamm HE, Sigler PB. Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein. Nature. 369: 621-8. PMID 8208289 DOI: 10.1038/369621a0  1
1994 Scott DL, Sigler PB. The structural and functional roles of calcium ion in secretory phospholipases A2. Advances in Inorganic Biochemistry. 10: 139-55. PMID 8203286  1
1994 Ladbury JE, Wright JG, Sturtevant JM, Sigler PB. A thermodynamic study of the trp repressor-operator interaction. Journal of Molecular Biology. 238: 669-81. PMID 8182742 DOI: 10.1006/jmbi.1994.1328  1
1994 Scott DL, Sigler PB. Structure and catalytic mechanism of secretory phospholipases A2. Advances in Protein Chemistry. 45: 53-88. PMID 8154374  1
1994 Shakked Z, Guzikevich-Guerstein G, Frolow F, Rabinovich D, Joachimiak A, Sigler PB. Determinants of repressor/operator recognition from the structure of the trp operator binding site. Nature. 368: 469-73. PMID 8133895 DOI: 10.1038/368469a0  1
1994 Sondek J, Lambright DG, Noel JP, Hamm HE, Sigler PB. GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4. Nature. 372: 276-9. PMID 7969474 DOI: 10.1038/372276a0  1
1994 Ferguson KM, Lemmon MA, Schlessinger J, Sigler PB. Crystal structure at 2.2 A resolution of the pleckstrin homology domain from human dynamin. Cell. 79: 199-209. PMID 7954789 DOI: 10.1016/0092-8674(94)90190-2  1
1994 Scott DL, Mandel AM, Sigler PB, Honig B. The electrostatic basis for the interfacial binding of secretory phospholipases A2. Biophysical Journal. 67: 493-504. PMID 7948668 DOI: 10.1016/S0006-3495(94)80546-6  1
1994 Braig K, Otwinowski Z, Hegde R, Boisvert DC, Joachimiak A, Horwich AL, Sigler PB. The crystal structure of the bacterial chaperonin GroEL at 2.8 A. Nature. 371: 578-86. PMID 7935790 DOI: 10.1038/371578a0  1
1994 Sigler PB. Chemogenetics. Nature Structural Biology. 1: 3-4. PMID 7656003  1
1993 Kim Y, Geiger JH, Hahn S, Sigler PB. Crystal structure of a yeast TBP/TATA-box complex. Nature. 365: 512-20. PMID 8413604 DOI: 10.1038/365512a0  1
1993 Noel JP, Hamm HE, Sigler PB. The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S. Nature. 366: 654-63. PMID 8259210 DOI: 10.1038/366654a0  1
1993 Xu W, Alroy I, Freedman LF, Sigler PB. Stereochemistry of specific steroid receptor-DNA interactions. Cold Spring Harbor Symposia On Quantitative Biology. 58: 133-9. PMID 7956023  1
1992 Haran TE, Joachimiak A, Sigler PB. The DNA target of the trp repressor. The Embo Journal. 11: 3021-30. PMID 1639072  1
1992 Scott DL, Achari A, Vidal JC, Sigler PB. Crystallographic and biochemical studies of the (inactive) Lys-49 phospholipase A2 from the venom of Agkistridon piscivorus piscivorus. The Journal of Biological Chemistry. 267: 22645-57. PMID 1429612  1
1992 Hegde RS, Grossman SR, Laimins LA, Sigler PB. Crystal structure at 1.7 A of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target. Nature. 359: 505-12. PMID 1328886 DOI: 10.1038/359505a0  1
1992 Pathak D, Sigler PB. Updating structure-function relationships in the bZip family of transcription factors. Current Opinion in Structural Biology 1992, 2:116...-123 Current Opinion in Structural Biology. 2: 116-123. DOI: 10.1016/0959-440X(92)90186-B  1
1992 Pathak D, Sigler PB. Updating structure-function relationships in the bZip family of transcription factors Current Opinion in Structural Biology. 2: 448.  1
1991 Scott DL, Otwinowski Z, Gelb MH, Sigler PB. Crystal structure of bee-venom phospholipase A2: correction. Science (New York, N.Y.). 252: 764. PMID 2028251  1
1991 Marmorstein RQ, Sprinzl M, Sigler PB. An alkaline phosphatase protection assay to investigate trp repressor/operator interactions. Biochemistry. 30: 1141-8. PMID 1989682  1
1991 Scott DL, White SP, Browning JL, Rosa JJ, Gelb MH, Sigler PB. Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate. Science (New York, N.Y.). 254: 1007-10. PMID 1948070  1
1991 Basavappa R, Sigler PB. The 3 A crystal structure of yeast initiator tRNA: functional implications in initiator/elongator discrimination. The Embo Journal. 10: 3105-11. PMID 1915284  1
1991 Myatt EA, Stevens FJ, Sigler PB. Effects of pH and calcium ion on self-association properties of two dimeric phospholipases A2. The Journal of Biological Chemistry. 266: 16331-5. PMID 1885568  1
1991 Luisi BF, Xu WX, Otwinowski Z, Freedman LP, Yamamoto KR, Sigler PB. Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA. Nature. 352: 497-505. PMID 1865905 DOI: 10.1038/352497a0  1
1991 Scott DL, Achari A, Christensen PA, Viljoen CC, Sigler PB. Crystallization and preliminary diffraction analysis of caudoxin and notexin; two monomeric phospholipase A2 neurotoxins. Toxicon : Official Journal of the International Society On Toxinology. 29: 1517-21. PMID 1801329 DOI: 10.1016/0041-0101(91)90009-G  1
1991 Joachimiak A, Sigler PB. Crystallization of protein-DNA complexes. Methods in Enzymology. 208: 82-99. PMID 1779853  1
1991 Joachimiak A, Giel M, Otwinowski Z, Arumae U, Siigur J, Saarma M, Sigler PB, Barciszewski J. Crystallization and preliminary X-ray analysis of nerve growth factor from Vipera lebetina Journal of Crystal Growth. 110: 214-219. DOI: 10.1016/0022-0248(91)90888-C  1
1991 Sigler PB. Protein-nucleic acid interactions. Current opinion in structural biology 1991, 1:61-62 Current Opinion in Structural Biology. 1: 61-62.  1
1990 Yuan W, Quinn DM, Sigler PB, Gelb MH. Kinetic and inhibition studies of phospholipase A2 with short-chain substrates and inhibitors. Biochemistry. 29: 6082-94. PMID 2383571  1
1990 Scott DL, Otwinowski Z, Gelb MH, Sigler PB. Crystal structure of bee-venom phospholipase A2 in a complex with a transition-state analogue. Science (New York, N.Y.). 250: 1563-6. PMID 2274788  1
1990 White SP, Scott DL, Otwinowski Z, Gelb MH, Sigler PB. Crystal structure of cobra-venom phospholipase A2 in a complex with a transition-state analogue. Science (New York, N.Y.). 250: 1560-3. PMID 2274787  1
1990 Scott DL, White SP, Otwinowski Z, Yuan W, Gelb MH, Sigler PB. Interfacial catalysis: the mechanism of phospholipase A2. Science (New York, N.Y.). 250: 1541-6. PMID 2274785  1
1990 Luisi BF, Sigler PB. The stereochemistry and biochemistry of the trp repressor-operator complex. Biochimica Et Biophysica Acta. 1048: 113-26. PMID 2182120 DOI: 10.1016/0167-4781(90)90047-6  1
1989 Kwong PD, Hendrickson WA, Sigler PB. Beta-bungarotoxin. Preparation and characterization of crystals suitable for structural analysis. The Journal of Biological Chemistry. 264: 19349-53. PMID 2808427  1
1989 Wagner T, Sigler PB, Gross M. Mechanism of inhibition of eukaryotic translational initiation by the trinucleotide ApUpG. Febs Letters. 250: 147-52. PMID 2753123 DOI: 10.1016/0014-5793(89)80708-2  1
1989 Vinson CR, Sigler PB, McKnight SL. Scissors-grip model for DNA recognition by a family of leucine zipper proteins. Science (New York, N.Y.). 246: 911-6. PMID 2683088  1
1989 Marmorstein RQ, Sigler PB. Stereochemical effects of L-tryptophan and its analogues on trp repressor's affinity for operator-DNA. The Journal of Biological Chemistry. 264: 9149-54. PMID 2656696  1
1989 Wagner T, Rundquist C, Gross M, Sigler PB. Structural features that underlie the use of bacterial Met-tRNAfMet primarily as an elongator in eukaryotic protein synthesis. The Journal of Biological Chemistry. 264: 18506-11. PMID 2478546  1
1988 Otwinowski Z, Schevitz RW, Zhang RG, Lawson CL, Joachimiak A, Marmorstein RQ, Luisi BF, Sigler PB. Crystal structure of trp repressor/operator complex at atomic resolution. Nature. 335: 321-9. PMID 3419502 DOI: 10.1038/335321a0  1
1988 Barlow PN, Lister MD, Sigler PB, Dennis EA. Probing the role of substrate conformation in phospholipase A2 action on aggregated phospholipids using constrained phosphatidylcholine analogues. The Journal of Biological Chemistry. 263: 12954-8. PMID 3417646  1
1988 Freedman LP, Yamamoto KR, Luisi BF, Sigler PB. More fingers in hand. Cell. 54: 444. PMID 3401923  1
1988 Lawson CL, Zhang RG, Schevitz RW, Otwinowski Z, Joachimiak A, Sigler PB. Flexibility of the DNA-binding domains of trp repressor. Proteins. 3: 18-31. PMID 3375234 DOI: 10.1002/prot.340030103  1
1988 Barlow PN, Vidal JC, Lister MD, Hancock AJ, Sigler PB. Synthesis and some properties of constrained short-chain phosphatidylcholine analogues: (+)- and (-)-(1,3/2)-1-O-(phosphocholine)2,3-O- dihexanoylcyclopentane-1,2,3-triol. Chemistry and Physics of Lipids. 46: 157-64. PMID 3370720 DOI: 10.1016/0009-3084(88)90017-5  1
1988 Sigler PB. Transcriptional activation. Acid blobs and negative noodles. Nature. 333: 210-2. PMID 3367995 DOI: 10.1038/333210a0  1
1988 Lawson CL, Sigler PB. The structure of trp pseudorepressor at 1.65A shows why indole propionate acts as a trp 'inducer'. Nature. 333: 869-71. PMID 3290685 DOI: 10.1038/333869a03386734  1
1988 Freedman LP, Luisi BF, Korszun ZR, Basavappa R, Sigler PB, Yamamoto KR. The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain. Nature. 334: 543-6. PMID 3043231 DOI: 10.1038/334543a0  1
1987 Wagner T, Gross M, Sigler PB. CpA containing oligoribonucleotides specifically inhibit protein synthesis in rabbit reticulocytes. Febs Letters. 212: 317-22. PMID 3817164 DOI: 10.1016/0014-5793(87)81368-6  1
1987 Zhang RG, Joachimiak A, Lawson CL, Schevitz RW, Otwinowski Z, Sigler PB. The crystal structure of trp aporepressor at 1.8 A shows how binding tryptophan enhances DNA affinity. Nature. 327: 591-7. PMID 3600756 DOI: 10.1038/327591a0  1
1987 Marmorstein RQ, Joachimiak A, Sprinzl M, Sigler PB. The structural basis for the interaction between L-tryptophan and the Escherichia coli trp aporepressor. The Journal of Biological Chemistry. 262: 4922-7. PMID 3549712  1
1987 Joachimiak A, Marmorstein RQ, Schevitz RW, Mandecki W, Fox JL, Sigler PB. Crystals of the trp repressor-operator complex suitable for X-ray diffraction analysis. The Journal of Biological Chemistry. 262: 4917-21. PMID 3549711  1
1987 Achari A, Scott D, Barlow P, Vidal JC, Otwinowski Z, Brunie S, Sigler PB. Facing up to membranes: structure/function relationships in phospholipases. Cold Spring Harbor Symposia On Quantitative Biology. 52: 441-52. PMID 3454272  1
1986 Scott DL, Achari A, Zajac M, Sigler PB. Crystallization and preliminary diffraction studies of the Lys-49 phospholipase A2 from Agkistrodon piscivorus piscivorus. The Journal of Biological Chemistry. 261: 12337-8. PMID 3091601  1
1985 Brunie S, Bolin J, Gewirth D, Sigler PB. The refined crystal structure of dimeric phospholipase A2 at 2.5 A. Access to a shielded catalytic center. The Journal of Biological Chemistry. 260: 9742-9. PMID 4019493  1
1985 Achari A, Radvanyi FR, Scott D, Bon C, Sigler PB. Crystals of crotoxin suitable for high resolution x-ray diffraction analysis. The Journal of Biological Chemistry. 260: 9385-7. PMID 4019477  1
1985 Schevitz RW, Otwinowski Z, Joachimiak A, Lawson CL, Sigler PB. The three-dimensional structure of trp repressor. Nature. 317: 782-6. PMID 3903514 DOI: 10.1038/317782a0  1
1985 Ackerman EJ, Joachimiak A, Klinghofer V, Sigler PB. Directly photocrosslinked nucleotides joining transfer RNA to aminoacyl-tRNA synthetase in methionine and tyrosine systems. Journal of Molecular Biology. 181: 93-102. PMID 2580097 DOI: 10.1016/0022-2836(85)90327-4  1
1984 Westbrook EM, Piro OE, Sigler PB. The 6-A crystal structure of delta 5-3-ketosteroid isomerase. Architecture and location of the active center. The Journal of Biological Chemistry. 259: 9096-103. PMID 6746641  1
1984 Westbrook EM, Sigler PB. Enzymatic function in crystals of delta 5-3-ketosteroid isomerase. Catalytic activity and binding of competitive inhibitors. The Journal of Biological Chemistry. 259: 9090-5. PMID 6746640  1
1984 Wagner T, Gross M, Sigler PB. Isoleucyl initiator tRNA does not initiate eucaryotic protein synthesis. The Journal of Biological Chemistry. 259: 4706-9. PMID 6370992  1
1983 Joachimiak A, Schevitz RW, Kelley RL, Yanofsky C, Sigler PB. Functional inferences from crystals of Escherichia coli trp repressor. The Journal of Biological Chemistry. 258: 12641-3. PMID 6355089  1
1983 Joachimiak A, Kelley RL, Gunsalus RP, Yanofsky C, Sigler PB. Purification and characterization of trp aporepressor. Proceedings of the National Academy of Sciences of the United States of America. 80: 668-72. PMID 6338493  1
1982 Chan YL, Ulbrich N, Ackerman EJ, Todokoro K, Slobin LI, Safer B, Sigler PB, Wool IG. The binding of transfer ribonucleic acids to 5 S and 5.8 S eukaryotic ribosomal ribonucleic acid-protein complexes. The Journal of Biological Chemistry. 257: 2522-7. PMID 7037766  1
1981 Keith C, Feldman DS, Deganello S, Glick J, Ward KB, Jones EO, Sigler PB. The 2.5 A crystal structure of a dimeric phospholipase A2 from the venom of Crotalus atrox. The Journal of Biological Chemistry. 256: 8602-7. PMID 7263673  1
1981 Chan SJ, Ackerman EJ, Quinn PS, Sigler PB, Steiner DF. Use of formylated yeast initiator Met tRNA to define the NH2-terminal residues of rat preproinsulin and pregrowth hormone. The Journal of Biological Chemistry. 256: 3271-5. PMID 6259159  1
1981 Schevitz RW, Podjarny AD, Zwick M, Hughes JJ, Sigler PB. Improving and extending the phases of medium‐ and low‐resolution macromolecular structure factors by density modification Acta Crystallographica Section A. 37: 669-677. DOI: 10.1107/S0567739481001526  1
1981 Podjarny AD, Schevitz RW, Sigler PB. Phasing low‐resolution macromolecular structure factors by matricial direct methods Acta Crystallographica Section A. 37: 662-668. DOI: 10.1107/S0567739481001514  1
1980 Ulbrich N, Wool IG, Ackerman E, Sigler PB. The identification by affinity chromatography of the rat liver ribosomal proteins that bind to elongator and initiator transfer ribonucleic acids. The Journal of Biological Chemistry. 255: 7010-9. PMID 7391064  1
1979 Rosa JJ, Rosa MD, Sigler PB. Photocross-linking analysis of the contact surface of tRNA Met in complexes with Escherichia coli methionine:tRNA ligase. Biochemistry. 18: 637-47. PMID 369605  1
1979 Schevitz RW, Podjarny AD, Krishnamachari N, Hughes JJ, Sigler PB, Sussman JL. Crystal structure of a eukaryotic initiator tRNA. Nature. 278: 188-90. PMID 368656 DOI: 10.1038/278188a0  1
1979 Tropp J, Sigler PB. Direct iodination of specific residues in crystals of yeast formylatable methionine-accepting transfer ribonucleic acid. Biochemistry. 18: 5489-95. PMID 117826  1
1978 Sigler PB, Ellen Druyan M, Zelano J. Cholera toxin crystals suitable for X-ray diffraction Journal of Supramolecular and Cellular Biochemistry. No. 349.  1
1977 Rosa MD, Sigler PB. Isolation and characterization of two methionine: tRNA ligases from wheat germ. European Journal of Biochemistry / Febs. 78: 141-51. PMID 913394  1
1977 Ohtsuki M, White SL, Zeitler E, Wellems TE, Fuller SD, Zwick M, Makinen MW, Sigler PB. Electron microscopy of fibers and discs of hemoglobin S having sixfold symmetry. Proceedings of the National Academy of Sciences of the United States of America. 74: 5538-42. PMID 271978  1
1976 Westbrook EM, Sigler PB, Berman H, Glusker JP, Bunick G, Benson A, Talalay P. Characterization of a monoclinic crystal form of an enzyme of steroid metabolism, Δ5-3-ketosteroid isomerase Journal of Molecular Biology. 103: 665-667. PMID 940161 DOI: 10.1016/0022-2836(76)90225-4  1
1975 Pasek M, Keith C, Feldman D, Sigler PB. Characterization of crystals of two venom phospholipases A2 Journal of Molecular Biology. 97: 395-396,IN25,397. PMID 1181469 DOI: 10.1016/S0022-2836(75)80048-9  1
1975 Sigler PB. An analysis of the structure of tRNA Annual Review of Biophysics and Bioengineering. 4: 477-527. PMID 1098566  1
1975 Anderson L, Bromberg EEA, Brunk C, Cahen D, Cogoli A, Cohen S, Cooper R, Dudock BS, Edelstein S, Faiman D, Frimer A, Gelman RA, Krystosek A, Leibovich SJ, Manz J, ... ... Sigler PB, et al. UNESCO Nature. 253: 85. DOI: 10.1038/253085a0  1
1974 Rosa JJ, Sigler PB. The site of covalent attachment in the crystalline osrnium-tRNAfMet isomorphous derivative Biochemistry. 13: 5102-5110. PMID 4611475  1
1973 Wherland S, Deutsch E, Eliason J, Sigler PB. Interactions between polynucleotides and platinum (II) complexes. Biochemical and Biophysical Research Communications. 54: 662-8. PMID 4756792 DOI: 10.1016/0006-291X(73)91474-5  1
1973 Cornick G, Sigler PB, Ginsberg HS. Mass of protein in the asymmetric unit of hexon crystals--a new method. Journal of Molecular Biology. 73: 533-8. PMID 4715015 DOI: 10.1016/0022-2836(73)90099-5  1
1973 Pasek M, Venkatappa MP, Sigler PB. Enzymatic synthesis and crystallographic characterization of an isomorphous derivative of yeast formylatable methionine transfer ribonucleic acid containing iodocytidine Biochemistry. 12: 4834-4840. PMID 4357548  1
1972 Schevitz RW, Navia MA, Bantz DA, Cornick G, Rosa JJ, Rosa MD, Sigler PB. An isomorphous heavy-atom derivative of crystaline formylmethionine transfer RNA. Science (New York, N.Y.). 177: 429-31. PMID 5043142  1
1971 Cornick G, Sigler PB, Ginsberg HS. Characterization of crystals of type 5 adenovirus hexon. Journal of Molecular Biology. 57: 397-401. PMID 5580435 DOI: 10.1016/0022-2836(71)90099-4  1
1970 Sigler PB. Iodination of a single tyrosine in crystals of α-chymotrypsin Biochemistry. 9: 3609-3617. PMID 5509845  1
1970 Johnson CD, Adolph K, Rosa JJ, Hall MD, Sigler PB. Crystallographic study of formylmethionine tRNA from baker's yeast. Nature. 226: 1246-7. PMID 5422598 DOI: 10.1038/2261246a0  1
1968 Sigler PB, Blow DM, Matthews BW, Henderson R. Structure of crystalline -chymotrypsin. II. A preliminary report including a hypothesis for the activation mechanism. Journal of Molecular Biology. 35: 143-64. PMID 5760561  1
1968 Hampel A, Labanauskas M, Connors PG, Kirkegard L, Rajbhandary UL, Sigler PB, Bock RM. Single crystals of transfer RNA from formylmethionine and phenylalanine transfer RNA's Science. 162: 1384-1387. PMID 4880853  1
1967 Matthews BW, Sigler PB, Henderson R, Blow DM. Three-dimensional structure of tosyl-alpha-chymotrypsin. Nature. 214: 652-6. PMID 6049071 DOI: 10.1038/214652a0  1
1966 Sigler PB, Jeffery BA, Matthews BW, Blow DM. An x-ray diffraction study of inhibited derivatives of alpha-chymotrypsin. Journal of Molecular Biology. 15: 175-92. PMID 5912039 DOI: 10.1016/S0022-2836(66)80219-X  1
1965 SASISEKHAREN V, SIGLER PB. AN X-RAY DIFFRACTION STUDY OF POLY (A+U) Journal of Molecular Biology. 12: 296-298. PMID 14343292  1
1965 Sigler PB, Blow DM. A means of promoting heavy-atom binding in protein crystals. Journal of Molecular Biology. 14: 640-4. PMID 5880874  1
1964 SIGLER PB, SKINNER HC, COULTER CL, KALLOS J, BRAXTON H, DAVIES DR. AN ISOMORPHOUS HEAVY ATOM SUBSTITUTION AT THE ACTIVE SITE OF Proceedings of the National Academy of Sciences of the United States Of. 51: 1146-1151. PMID 14215636 DOI: 10.1073/pnas.51.6.1146  1
1963 Sigler PB, Skinner HCW. The reaction of diisopropylfluorophosphate with crystals of γ-chymotrypsin Biochemical and Biophysical Research Communications. 13: 236-240.  1
1962 SIGLER PB, DAVIES DR, MILES HT. A displacement reaction between a polynucleotide Helix and a random coil Journal of Molecular Biology. 5: 709-717. PMID 13989046 DOI: 10.1016/S0022-2836(62)80097-7  1
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