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Russell F. Doolittle - Publications

Affiliations: 
University of California, San Diego, La Jolla, CA 
Area:
blood coagulation
Website:
http://www-chem.ucsd.edu/faculty/profiles/doolittle_russell_f.html

198 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Doolittle RF. Bioinformatic Characterization of Genes and Proteins Involved in Blood Clotting in Lampreys. Journal of Molecular Evolution. 81: 121-30. PMID 26437661 DOI: 10.1007/S00239-015-9701-0  1
2014 Doolittle RF. Clotting of mammalian fibrinogens by papain: a re-examination. Biochemistry. 53: 6687-94. PMID 25283163 DOI: 10.1021/Bi5010987  1
2012 Doolittle RF, McNamara K, Lin K. Correlating structure and function during the evolution of fibrinogen-related domains. Protein Science : a Publication of the Protein Society. 21: 1808-23. PMID 23076991 DOI: 10.1002/Pro.2177  1
2012 Doolittle RF. The protochordate Ciona intestinalis has a protein like full-length vertebrate fibrinogen. Journal of Innate Immunity. 4: 219-22. PMID 21860218 DOI: 10.1159/000329823  1
2011 Watson JW, Doolittle RF. Peptide-derivatized albumins that inhibit fibrin polymerization. Biochemistry. 50: 9923-7. PMID 22010909 DOI: 10.1021/Bi201406C  1
2011 Doolittle RF. Clots vs bugs: who's ahead? Blood. 118: 2382-4. PMID 21885608 DOI: 10.1182/Blood-2011-06-357574  1
2011 Doolittle RF. Coagulation in vertebrates with a focus on evolution and inflammation. Journal of Innate Immunity. 3: 9-16. PMID 20980726 DOI: 10.1159/000321005  1
2010 Doolittle RF. The roots of bioinformatics in protein evolution. Plos Computational Biology. 6: e1000875. PMID 20686682 DOI: 10.1371/Journal.Pcbi.1000875  1
2010 Doolittle RF. Structural basis of signaling events involving fibrinogen and fibrin Handbook of Cell Signaling, 2/E. 1: 111-114. DOI: 10.1016/B978-0-12-374145-5.00017-6  1
2009 Doolittle RF. Step-by-step evolution of vertebrate blood coagulation. Cold Spring Harbor Symposia On Quantitative Biology. 74: 35-40. PMID 19667012 DOI: 10.1101/Sqb.2009.74.001  1
2009 Pandi L, Kollman JM, Lopez-Lira F, Burrows JM, Riley M, Doolittle RF. Two families of synthetic peptides that enhance fibrin turbidity and delay fibrinolysis by different mechanisms. Biochemistry. 48: 7201-8. PMID 19588915 DOI: 10.1021/Bi900647G  1
2009 Doolittle RF, Hong S, Wilcox D. Evolution of the fibrinogen gamma' chain: implications for the binding of factor XIII, thrombin and platelets. Journal of Thrombosis and Haemostasis : Jth. 7: 1431-3. PMID 19552683 DOI: 10.1111/J.1538-7836.2009.03519.X  1
2009 Kollman JM, Pandi L, Sawaya MR, Riley M, Doolittle RF. Crystal structure of human fibrinogen. Biochemistry. 48: 3877-86. PMID 19296670 DOI: 10.1021/Bi802205G  1
2008 Ponczek MB, Gailani D, Doolittle RF. Evolution of the contact phase of vertebrate blood coagulation. Journal of Thrombosis and Haemostasis : Jth. 6: 1876-83. PMID 18761718 DOI: 10.1111/J.1538-7836.2008.03143.X  1
2008 Doolittle RF. Searching for differences between fibrinogen and fibrin that affect the initiation of fibrinolysis. Cardiovascular & Hematological Agents in Medicinal Chemistry. 6: 181-9. PMID 18673232 DOI: 10.2174/187152508784871954  1
2008 Doolittle RF, Jiang Y, Nand J. Genomic evidence for a simpler clotting scheme in jawless vertebrates. Journal of Molecular Evolution. 66: 185-96. PMID 18283387 DOI: 10.1007/S00239-008-9074-8  1
2007 Doolittle RF, Pandi L. Probing the beta-chain hole of fibrinogen with synthetic peptides that differ at their amino termini. Biochemistry. 46: 10033-8. PMID 17688324 DOI: 10.1021/Bi7010916  1
2006 Rojas A, Doolittle RF. The occurrence of type S1A serine proteases in sponge and jellyfish. Journal of Molecular Evolution. 55: 790-4. PMID 17476731 DOI: 10.1007/S00239-002-2361-X  1
2006 Doolittle RF, Chen A, Pandi L. Differences in binding specificity for the homologous gamma- and beta-chain "holes" on fibrinogen: exclusive binding of Ala-His-Arg-Pro-amide by the beta-chain hole. Biochemistry. 45: 13962-9. PMID 17115691 DOI: 10.1021/Bi061219E  1
2006 Doolittle RF, Pandi L. Binding of synthetic B knobs to fibrinogen changes the character of fibrin and inhibits its ability to activate tissue plasminogen activator and its destruction by plasmin. Biochemistry. 45: 2657-67. PMID 16489759 DOI: 10.1021/Bi0524767  1
2006 Doolittle RF, Kollman JM. Natively unfolded regions of the vertebrate fibrinogen molecule. Proteins. 63: 391-7. PMID 16288455 DOI: 10.1002/Prot.20758  1
2005 Doolittle RF. Evolutionary aspects of whole-genome biology. Current Opinion in Structural Biology. 15: 248-53. PMID 15963888 DOI: 10.1016/J.Sbi.2005.04.001  1
2005 Kollman JM, Doolittle RF. Unusual non-crystallographic symmetry in crystals of a 420 kDa crustacean clottable protein. Acta Crystallographica. Section D, Biological Crystallography. 61: 485-9. PMID 15805605 DOI: 10.1107/S0907444905000910  1
2005 Sirinupong N, Suwanmanee P, Doolittle RF, Suvachitanont W. Molecular cloning of a new cDNA and expression of 3-hydroxy-3-methylglutaryl-CoA synthase gene from Hevea brasiliensis. Planta. 221: 502-12. PMID 15744497 DOI: 10.1007/S00425-004-1463-7  1
2005 Yang S, Doolittle RF, Bourne PE. Phylogeny determined by protein domain content. Proceedings of the National Academy of Sciences of the United States of America. 102: 373-8. PMID 15630082 DOI: 10.1073/Pnas.0408810102  1
2004 Doolittle RF. Martin David Kamen (27 August 1913 - 31 August 2002). Proceedings of the American Philosophical Society. 148: 499-503. PMID 15818877  1
2004 Doolittle RF. Some comments on John Ferry's most enduring paper. Biophysical Chemistry. 112: 177-80. PMID 15572245 DOI: 10.1016/J.Bpc.2004.07.045  1
2004 Doolittle RF. Determining the crystal structure of fibrinogen. Journal of Thrombosis and Haemostasis : Jth. 2: 683-9. PMID 15099268 DOI: 10.1111/J.1538-7933.2004.00664.X  1
2004 Doolittle RF. Fifty years of sequence analysis: What have we learned? Proceedings of the Annual International Conference On Computational Molecular Biology, Recomb. 8: 281.  1
2004 Doolittle R. Why the computer scientist should think like an evolutionist Proceedings of the 2004 Ieee Symposium On Computational Intelligence in Bioinformatics and Computational Biology, Cibcb'04. v.  1
2003 Doolittle RF. X-ray crystallographic studies on fibrinogen and fibrin. Journal of Thrombosis and Haemostasis : Jth. 1: 1559-65. PMID 12871291 DOI: 10.1046/J.1538-7836.2003.00278.X  1
2003 Jiang Y, Doolittle RF. The evolution of vertebrate blood coagulation as viewed from a comparison of puffer fish and sea squirt genomes. Proceedings of the National Academy of Sciences of the United States of America. 100: 7527-32. PMID 12808152 DOI: 10.1073/Pnas.0932632100  1
2003 Doolittle RF. Some notes on crystallizing fibrinogen and fibrin fragments. Biophysical Chemistry. 100: 307-13. PMID 12646373 DOI: 10.1016/S0301-4622(02)00288-0  1
2003 Doolittle RF. Structural basis of the fibrinogen-fibrin transformation: contributions from X-ray crystallography. Blood Reviews. 17: 33-41. PMID 12490209 DOI: 10.1016/S0268-960X(02)00060-7  1
2002 Yang Z, Pandi L, Doolittle RF. The crystal structure of fragment double-D from cross-linked lamprey fibrin reveals isopeptide linkages across an unexpected D-D interface. Biochemistry. 41: 15610-7. PMID 12501189 DOI: 10.1021/Bi026666I  1
2002 Doolittle RF. The grand assault. Nature. 419: 493-4. PMID 12368861 DOI: 10.1038/419493A  1
2002 Yang Z, Spraggon G, Pandi L, Everse SJ, Riley M, Doolittle RF. Crystal structure of fragment D from lamprey fibrinogen complexed with the peptide Gly-His-Arg-Pro-amide. Biochemistry. 41: 10218-24. PMID 12162736 DOI: 10.1021/Bi020299T  1
2002 Doolittle RF. Biodiversity: microbial genomes multiply. Nature. 416: 697-700. PMID 11961543 DOI: 10.1038/416697A  1
2002 Doolittle RF, York AL. Bacterial actins? An evolutionary perspective. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 24: 293-6. PMID 11948613 DOI: 10.1002/Bies.10079  1
2001 Yang Z, Kollman JM, Pandi L, Doolittle RF. Crystal structure of native chicken fibrinogen at 2.7 A resolution. Biochemistry. 40: 12515-23. PMID 11601975 DOI: 10.1021/Bi011394P  1
2001 Doolittle RF, Yang Z, Mochalkin I. Crystal structure studies on fibrinogen and fibrin. Annals of the New York Academy of Sciences. 936: 31-43. PMID 11460486 DOI: 10.1111/J.1749-6632.2001.Tb03492.X  1
2001 Doolittle RF. Sequences and computers: A personal reflection on the digital age Proceedings of the Atlantic Symposium On Computational Biology and Genome Information Systems and Technolgoy, Cbgist 2001. 4.  1
2000 Yang Z, Mochalkin I, Doolittle RF. A model of fibrin formation based on crystal structures of fibrinogen and fibrin fragments complexed with synthetic peptides. Proceedings of the National Academy of Sciences of the United States of America. 97: 14156-61. PMID 11121023 DOI: 10.1073/Pnas.97.26.14156  1
2000 Kollman JM, Doolittle RF. Determining the relative rates of change for prokaryotic and eukaryotic proteins with anciently duplicated paralogs. Journal of Molecular Evolution. 51: 173-81. PMID 10948274 DOI: 10.1007/S002390010078  1
2000 Doolittle RF. Searching for the common ancestor. Research in Microbiology. 151: 85-9. PMID 10865952 DOI: 10.1016/S0923-2508(00)00124-8  1
2000 Doolittle RF. On the trail of protein sequences. Bioinformatics (Oxford, England). 16: 24-33. PMID 10812474 DOI: 10.1093/Bioinformatics/16.1.24  1
2000 Yang Z, Mochalkin I, Veerapandian L, Riley M, Doolittle RF. Crystal structure of native chicken fibrinogen at 5.5-A resolution. Proceedings of the National Academy of Sciences of the United States of America. 97: 3907-12. PMID 10737772 DOI: 10.1073/Pnas.080065697  1
2000 Lin YC, Doolittle RF. A latent inhibitor of fibrin polymerization with ancillary anticoagulant activity. Thrombosis Research. 97: 375-8. PMID 10709915 DOI: 10.1016/S0049-3848(99)00170-X  1
1999 Doolittle RF, Feng DF, Cho G. Determining divergence times with protein clocks. The Biological Bulletin. 196: 356-7; discussion 35. PMID 11536911 DOI: 10.2307/1542969  1
1999 Doolittle RF, Spraggon G, Everse SJ. Crystal structures of fragments D and double-D from fibrinogen and fibrin. Thrombosis and Haemostasis. 82: 271-6. PMID 10605713  1
1999 Handy J, Doolittle RF. An attempt to pinpoint the phylogenetic introduction of glutaminyl-tRNA synthetase among bacteria. Journal of Molecular Evolution. 49: 709-15. PMID 10594171 DOI: 10.1007/Pl00006592  1
1999 Doolittle RF. Do you dig my groove? Nature Genetics. 23: 6-8. PMID 10471485 DOI: 10.1038/12597  1
1999 Everse SJ, Spraggon G, Veerapandian L, Doolittle RF. Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide. Biochemistry. 38: 2941-6. PMID 10074346 DOI: 10.1021/Bi982626W  1
1998 Doolittle RF, Spraggon G, Everse SJ. Three-dimensional structural studies on fragments of fibrinogen and fibrin. Current Opinion in Structural Biology. 8: 792-8. PMID 9914253 DOI: 10.1016/S0959-440X(98)80100-0  1
1998 Doolittle RF, Handy J. Evolutionary anomalies among the aminoacyl-tRNA synthetases. Current Opinion in Genetics & Development. 8: 630-6. PMID 9914200 DOI: 10.1016/S0959-437X(98)80030-0  1
1998 Varki A, Wills C, Perlmutter D, Woodruff D, Gage F, Moore J, Semendeferi K, Bernirschke K, Katzman R, Doolittle R, Bullock T. Great Ape Phenome Project? Science (New York, N.Y.). 282: 239-40. PMID 9841385 DOI: 10.1126/Science.282.5387.239D  1
1998 Spraggon G, Applegate D, Everse SJ, Zhang JZ, Veerapandian L, Redman C, Doolittle RF, Grieninger G. Crystal structure of a recombinant alphaEC domain from human fibrinogen-420. Proceedings of the National Academy of Sciences of the United States of America. 95: 9099-104. PMID 9689040 DOI: 10.1073/Pnas.95.16.9099  1
1998 Everse SJ, Spraggon G, Doolittle RF. A three-dimensional consideration of variant human fibrinogens. Thrombosis and Haemostasis. 80: 1-9. PMID 9684777 DOI: 10.1055/S-0037-1615130  1
1998 Everse SJ, Spraggon G, Veerapandian L, Riley M, Doolittle RF. Crystal structure of fragment double-D from human fibrin with two different bound ligands. Biochemistry. 37: 8637-42. PMID 9628725 DOI: 10.1021/Bi9804129  1
1998 Tsyguelnaia I, Doolittle RF. Presence of a fibronectin type III domain in a plant protein. Journal of Molecular Evolution. 46: 612-4. PMID 9545471 DOI: 10.1007/Pl00013148  1
1998 Doolittle RF. Microbial genomes opened up. Nature. 392: 339-42. PMID 9537318 DOI: 10.1038/32789  1
1997 Doolittle RF, Spraggon G, Everse SJ. Evolution of vertebrate fibrin formation and the process of its dissolution. Ciba Foundation Symposium. 212: 4-17; discussion 17-. PMID 9524761  1
1997 Feng DF, Cho G, Doolittle RF. Determining divergence times with a protein clock: update and reevaluation. Proceedings of the National Academy of Sciences of the United States of America. 94: 13028-33. PMID 9371794 DOI: 10.1073/Pnas.94.24.13028  1
1997 Doolittle RF. A bug with excess gastric avidity. Nature. 388: 515-6. PMID 9252182 DOI: 10.1038/41418  1
1997 Cho G, Doolittle RF. Intron distribution in ancient paralogs supports random insertion and not random loss. Journal of Molecular Evolution. 44: 573-84. PMID 9169549 DOI: 10.1007/Pl00006180  1
1997 Doolittle RF. Some reflections on the early days of sequence searching. Journal of Molecular Medicine (Berlin, Germany). 75: 239-41. PMID 9151208  1
1997 Feng DF, Doolittle RF. Converting amino acid alignment scores into measures of evolutionary time: a simulation study of various relationships. Journal of Molecular Evolution. 44: 361-70. PMID 9089075 DOI: 10.1007/Pl00006155  1
1997 Doolittle RF, Everse SJ, Spraggon G. Nature as a protein engineer: the important but subtle differences that distinguish fibrin from fibrinogen Faseb Journal. 11: A872.  1
1996 Hasegawa M, Fitch WM, Gogarten JP, Olendzenski L, Hilario E, Simon C, Holsinger KE, Doolittle RF, Feng DF, Tsang S, Cho G, Little E. Dating the cenancester of organisms Science. 274: 1750-1753. PMID 8984636 DOI: 10.1126/science.274.5293.1750  1
1996 Roger AJ, Smith MW, Doolittle RF, Doolittle WF. Evidence for the Heterolobosea from phylogenetic analysis of genes encoding glyceraldehyde-3-phosphate dehydrogenase. The Journal of Eukaryotic Microbiology. 43: 475-85. PMID 8976605 DOI: 10.1111/J.1550-7408.1996.Tb04507.X  1
1996 Doolittle RF, Everse SJ, Spraggon G. Human fibrinogen: anticipating a 3-dimensional structure. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 10: 1464-70. PMID 8940292 DOI: 10.1096/Fasebj.10.13.8940292  1
1996 Feng DF, Doolittle RF. Progressive alignment of amino acid sequences and construction of phylogenetic trees from them. Methods in Enzymology. 266: 368-82. PMID 8743694 DOI: 10.1016/S0076-6879(96)66023-6  1
1996 Doolittle RF. Overview of the symposium on molecular anthropology. Wayne State University, March 13-14, 1995. Molecular Phylogenetics and Evolution. 5: 266-8. PMID 8673295  1
1996 Doolittle RF, Feng DF, Tsang S, Cho G, Little E. Determining divergence times of the major kingdoms of living organisms with a protein clock. Science (New York, N.Y.). 271: 470-7. PMID 8560259 DOI: 10.1126/Science.271.5248.470  1
1995 Doolittle RF. The origins and evolution of eukaryotic proteins. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 349: 235-40. PMID 8577833 DOI: 10.1098/Rstb.1995.0107  1
1995 Shipwash E, Pan Y, Doolittle RF. The minor form alpha' chain from lamprey fibrinogen is rapidly crosslinked during clotting. Proceedings of the National Academy of Sciences of the United States of America. 92: 968-72. PMID 7862675 DOI: 10.1073/Pnas.92.4.968  1
1995 Nagel GM, Doolittle RF. Phylogenetic analysis of the aminoacyl-tRNA synthetases. Journal of Molecular Evolution. 40: 487-98. PMID 7783224 DOI: 10.1007/Bf00166617  1
1995 Doolittle RF. Of archae and eo: what's in a name? Proceedings of the National Academy of Sciences of the United States of America. 92: 2421-3. PMID 7708656 DOI: 10.1073/Pnas.92.7.2421  1
1995 Everse SJ, Pelletier H, Doolittle RF. Crystallization of fragment D from human fibrinogen. Protein Science : a Publication of the Protein Society. 4: 1013-6. PMID 7663337 DOI: 10.1002/Pro.5560040523  1
1995 Doolittle RF. The multiplicity of domains in proteins. Annual Review of Biochemistry. 64: 287-314. PMID 7574483 DOI: 10.1146/Annurev.Bi.64.070195.001443  1
1995 Soll D, Doolittle R. Overview of the meeting Journal of Molecular Evolution. 40: 475.  1
1994 Doolittle RF. Convergent evolution: the need to be explicit. Trends in Biochemical Sciences. 19: 15-8. PMID 8140615 DOI: 10.1016/0968-0004(94)90167-8  1
1994 Bork P, Doolittle RF. Drosophila kelch motif is derived from a common enzyme fold. Journal of Molecular Biology. 236: 1277-82. PMID 8126718 DOI: 10.1016/0022-2836(94)90056-6  1
1994 Doolittle RF. Protein sequence comparisons: searching databases and aligning sequences. Current Opinion in Biotechnology. 5: 24-8. PMID 7764639 DOI: 10.1016/S0958-1669(05)80065-5  1
1994 Little E, Bork P, Doolittle RF. Tracing the spread of fibronectin type III domains in bacterial glycohydrolases. Journal of Molecular Evolution. 39: 631-43. PMID 7528812 DOI: 10.1007/Bf00160409  1
1994 Doolittle RF. The early evolutionary history of proteins Bolletino Di Zoologia. 61: 99-103. DOI: 10.1080/11250009409355867  1
1993 Narumi H, Hishida T, Sasaki T, Feng DF, Doolittle RF. Molecular cloning of silkworm (Bombyx mori) antichymotrypsin. A new member of the serpin superfamily of proteins from insects. European Journal of Biochemistry / Febs. 214: 181-7. PMID 8508791 DOI: 10.1111/J.1432-1033.1993.Tb17911.X  1
1993 Doolittle RF. The comings and goings of homing endonucleases and mobile introns. Proceedings of the National Academy of Sciences of the United States of America. 90: 5379-81. PMID 8390659 DOI: 10.1073/Pnas.90.12.5379  1
1993 Bork P, Doolittle RF. Fibronectin type III modules in the receptor phosphatase CD45 and tapeworm antigens. Protein Science : a Publication of the Protein Society. 2: 1185-7. PMID 8358302 DOI: 10.1002/Pro.5560020714  1
1993 Doolittle RF. The evolution of vertebrate blood coagulation: a case of Yin and Yang. Thrombosis and Haemostasis. 70: 24-8. PMID 8236110 DOI: 10.1055/S-0038-1646154  1
1993 Doolittle RF, Bork P. Evolutionarily mobile modules in proteins. Scientific American. 269: 50-6. PMID 8235550 DOI: 10.1038/Scientificamerican1093-50  1
1993 Doolittle RF, Blundell TL. Sequences and topology. Unity and diversity all over again Current Opinion in Structural Biology. 3: 377-378. DOI: 10.1016/S0959-440X(05)80109-5  1
1992 Smith MW, Doolittle RF. Anomalous phylogeny involving the enzyme glucose-6-phosphate isomerase. Journal of Molecular Evolution. 34: 544-5. PMID 1593646 DOI: 10.1007/Bf00160467  1
1992 Yamazumi K, Doolittle RF. Photoaffinity labeling of the primary fibrin polymerization site: localization of the label to gamma-chain Tyr-363. Proceedings of the National Academy of Sciences of the United States of America. 89: 2893-6. PMID 1557396 DOI: 10.1073/Pnas.89.7.2893  1
1992 Shimizu A, Nagel GM, Doolittle RF. Photoaffinity labeling of the primary fibrin polymerization site: isolation and characterization of a labeled cyanogen bromide fragment corresponding to gamma-chain residues 337-379. Proceedings of the National Academy of Sciences of the United States of America. 89: 2888-92. PMID 1557395 DOI: 10.1073/Pnas.89.7.2888  1
1992 Smith MW, Doolittle RF. A comparison of evolutionary rates of the two major kinds of superoxide dismutase. Journal of Molecular Evolution. 34: 175-84. PMID 1556751 DOI: 10.1007/Bf00182394  1
1992 Pan Y, Doolittle RF. cDNA sequence of a second fibrinogen alpha chain in lamprey: an archetypal version alignable with full-length beta and gamma chains. Proceedings of the National Academy of Sciences of the United States of America. 89: 2066-70. PMID 1549566 DOI: 10.1073/Pnas.89.6.2066  1
1992 Smith MW, Feng DF, Doolittle RF. Evolution by acquisition: the case for horizontal gene transfers. Trends in Biochemical Sciences. 17: 489-93. PMID 1471257 DOI: 10.1016/0968-0004(92)90335-7  1
1992 Bork P, Doolittle RF. Proposed acquisition of an animal protein domain by bacteria. Proceedings of the National Academy of Sciences of the United States of America. 89: 8990-4. PMID 1409594 DOI: 10.1073/Pnas.89.19.8990  1
1992 Doolittle RF, Feng DF. Tracing the origin of retroviruses. Current Topics in Microbiology and Immunology. 176: 195-211. PMID 1376225 DOI: 10.1007/978-3-642-77011-1_13  1
1992 Doolittle RF, Riley M, Pan Y. Direct measurement of a second fibrinogen alpha chain in lamprey blood plasma. Thrombosis Research. 68: 489-93. PMID 1341060 DOI: 10.1016/0049-3848(92)90062-F  1
1992 Doolittle RF. Stein and Moore Award address. Reconstructing history with amino acid sequences. Protein Science : a Publication of the Protein Society. 1: 191-200. PMID 1339026 DOI: 10.1002/Pro.5560010201  1
1992 Gray JE, Doolittle RF. Characterization, primary structure, and evolution of lamprey plasma albumin. Protein Science : a Publication of the Protein Society. 1: 289-302. PMID 1304910 DOI: 10.1002/Pro.5560010211  1
1992 Yamazumi K, Doolittle RF. The synthetic peptide Gly-Pro-Arg-Pro-amide limits the plasmic digestion of fibrinogen in the same fashion as calcium ion. Protein Science : a Publication of the Protein Society. 1: 1719-20. PMID 1304901 DOI: 10.1002/Pro.5560011220  1
1992 Doolittle RF. A detailed consideration of a principal domain of vertebrate fibrinogen and its relatives. Protein Science : a Publication of the Protein Society. 1: 1563-77. PMID 1304888 DOI: 10.1002/Pro.5560011204  1
1992 Blundell TL, Doolittle RF. Sequences and topology-An inverse approach to the old folding problem. Editorial overview Current Opinion in Structural Biology. 2: 381-383. DOI: 10.1016/0959-440X(92)90228-Y  1
1992 Doolittle RF. Amino acid sequence comparison as an aid to determining evolutionary origins Journal of Protein Chemistry. 11: 422. DOI: 10.1007/978-1-4899-1603-7_31  1
1992 Doolittle RF. Of compact disks and expanded minds Protein Science. 1: 1537. DOI: 10.1002/Pro.5560011201  1
1991 Doolittle RF. The structure and evolution of vertebrate fibrinogen: A comparison of the lamprey and mammalian proteins Advances in Experimental Medicine and Biology. 281: 25-37. PMID 2102616 DOI: 10.1007/978-1-4615-3806-6_2  1
1991 Doolittle RF. Biotechnology--the enormous cost of success. The New England Journal of Medicine. 324: 1360-2. PMID 2017234 DOI: 10.1056/Nejm199105093241910  1
1991 Nagel GM, Doolittle RF. Evolution and relatedness in two aminoacyl-tRNA synthetase families. Proceedings of the National Academy of Sciences of the United States of America. 88: 8121-5. PMID 1896459 DOI: 10.1073/Pnas.88.18.8121  1
1991 Doolittle RF. Counting and discounting the universe of exons. Science (New York, N.Y.). 253: 677-80. PMID 1871603 DOI: 10.1126/Science.1871603  1
1991 Blundell TL, Doolittle RF. Sequences and topology Editorial overview Current Opinion in Structural Biology. 1: 319-320. DOI: 10.1016/0959-440X(91)90028-R  1
1990 Xu X, Doolittle RF. Presence of a vertebrate fibrinogen-like sequence in an echinoderm Proceedings of the National Academy of Sciences of the United States of America. 87: 2097-2101. PMID 2315305 DOI: 10.1073/Pnas.87.6.2097  1
1990 Doolittle RF. Searching through sequence databases Methods in Enzymology. 183: 99-110. PMID 2314299 DOI: 10.1016/0076-6879(90)83008-W  1
1990 Doolittle RF, Feng DF. Nearest neighbor procedure for relating progressively aligned amino acid sequences Methods in Enzymology. 183: 659-669. PMID 2314298 DOI: 10.1016/0076-6879(90)83043-9  1
1990 Feng DF, Doolittle RF. [23] Progressive alignment and phylogenetic tree construction of protein sequences Methods in Enzymology. 183: 375-387. PMID 2314283 DOI: 10.1016/0076-6879(90)83025-5  1
1990 Doolittle RF, Riley M. The amino-terminal sequence of lobster fibrinogen reveals common ancestry with vitellogenins Biochemical and Biophysical Research Communications. 167: 16-19. PMID 2310387 DOI: 10.1016/0006-291X(90)91723-6  1
1990 Doolittle RF. Epidermal growth factor. Science (New York, N.Y.). 250: 1319. PMID 2255900 DOI: 10.1126/Science.250.4986.1319-B  1
1990 Doolittle RF, Feng DF, McClure MA, Johnson MS. Retrovirus phylogeny and evolution Current Topics in Microbiology and Immunology. 157: 1-18. PMID 2203607 DOI: 10.1007/978-3-642-75218-6_1  1
1990 Doolittle RF, Feng DF, Anderson KL, Alberro MR. A naturally occurring horizontal gene transfer from a eukaryote to a prokaryote. Journal of Molecular Evolution. 31: 383-8. PMID 2124629 DOI: 10.1007/Bf02106053  1
1990 Seely O, Feng DF, Smith DW, Sulzbach D, Doolittle RF. Construction of a facsimile data set for large genome sequence analysis. Genomics. 8: 71-82. PMID 2081603 DOI: 10.1016/0888-7543(90)90227-L  1
1990 Doolittle RF. Molecular evolution: Computer analysis of protein and nucleic acid sequences Methods in Enzymology. 183: xiii-xiv.  1
1989 Doolittle RF. Similar amino acid sequences revisited Trends in Biochemical Sciences. 14: 244-245. PMID 2773041 DOI: 10.1016/0968-0004(89)90055-8  1
1989 Doolittle RF. The simian - Human connection Nature. 339: 338-339. PMID 2725658 DOI: 10.1038/339338A0  1
1989 Wang YZ, Patterson J, Gray JE, Yu C, Cottrell BA, Shimizu A, Graham D, Riley M, Doolittle RF. Complete sequence of the lamprey fibrinogen α chain Biochemistry. 28: 9801-9806. PMID 2611265 DOI: 10.1021/Bi00451A039  1
1989 Doolittle RF, Feng DF, Johnson MS, McClure MA. Origins and evolutionary relationships of retroviruses Quarterly Review of Biology. 64: 1-30. PMID 2469098 DOI: 10.1086/416128  1
1989 Doolittle RF, Anderson KL, Feng DF. Estimating the prokaryote-eukaryote divergence time from protein sequences The Hierarchy of Life. Molecules and Morphology in Phylogenetic Analysis: Proceedings From Nobel Symposium 70. Ics824. 73-85.  1
1988 Doolittle RF. Lens proteins. More molecular opportunism Nature. 336: 18. PMID 3185715 DOI: 10.1038/336018A0  1
1988 Saier MH, Yamada M, Erni B, Suda K, Lengeler J, Ebner R, Argos P, Rak B, Schnetz K, Lee CA, Stewart GC, Breidt F, Waygood EB, Peri KG, Doolittle RF. Sugar permeases of the bacterial phosphoenolpyruvate-dependent phosphotransferase system: Sequence comparisons Faseb Journal. 2: 199-208. PMID 2832233 DOI: 10.1096/fasebj.2.3.2832233  1
1988 McClure MA, Johnson MS, Feng DF, Doolittle RF. Sequence comparisons of retroviral proteins: relative rates of change and general phylogeny Proceedings of the National Academy of Sciences of the United States of America. 85: 2469-2473. PMID 2451824 DOI: 10.1073/Pnas.85.8.2469  1
1988 Doolittle RF. More molecular opportunism Nature. 336: 18.  1
1987 Reeck GR, de Haën C, Teller DC, Doolittle RF, Fitch WM, Dickerson RE, Chambon P, McLachlan AD, Margoliash E, Jukes TH. "Homology" in proteins and nucleic acids: a terminology muddle and a way out of it. Cell. 50: 667. PMID 3621342 DOI: 10.1016/0092-8674(87)90322-9  1
1987 Pontes M, Xu X, Graham D, Riley M, Doolittle RF. cDNA sequences of two apolipoproteins from lamprey Biochemistry. 26: 1611-1617. PMID 3593681  1
1987 Vogt PK, Bos TJ, Doolittle RF. Homology between the DNA-binding domain of the GCN4 regulatory protein of yeast and the carboxyl-terminal region of a protein coded for by the oncogene jun Proceedings of the National Academy of Sciences of the United States of America. 84: 3316-3319. PMID 3554236 DOI: 10.1073/Pnas.84.10.3316  1
1987 Doolittle RF, Feng DF. Reconstructing the evolution of vertebrate blood coagulation from a consideration of the amino acid sequences of clotting proteins Cold Spring Harbor Symposia On Quantitative Biology. 52: 869-874. PMID 3483343 DOI: 10.1101/Sqb.1987.052.01.095  1
1987 Feng DF, Doolittle RF. Progressive sequence alignment as a prerequisitetto correct phylogenetic trees Journal of Molecular Evolution. 25: 351-360. PMID 3118049 DOI: 10.1007/Bf02603120  1
1987 McClure MA, Johnson MS, Doolittle RF. Relocation of a protease-like gene segment between two retroviruses Proceedings of the National Academy of Sciences of the United States of America. 84: 2693-2697. PMID 3106974 DOI: 10.1073/Pnas.84.9.2693  1
1986 Bohonus VL, Doolittle RF, Pontes M, Strong DD. Complementary DNA sequence of lamprey fibrinogen β chain Biochemistry. 25: 6512-6516. PMID 3790537 DOI: 10.1021/Bi00369A026  1
1986 Kuyas C, Doolittle RF. GLY-PRO-ARG-Pro derivatives that bind to human plasma albumin and prevent fibrin formation Thrombosis Research. 43: 485-490. PMID 3764804 DOI: 10.1016/0049-3848(86)90093-9  1
1986 Chomyn A, Cleeter MW, Ragan CI, Riley M, Doolittle RF, Attardi G. URF6, last unidentified reading frame of human mtDNA, codes for an NADH dehydrogenase subunit. Science (New York, N.Y.). 234: 614-8. PMID 3764430 DOI: 10.1126/Science.3764430  1
1986 Doolittle RF, Johnson MS, Husain I, Van Houten B, Thomas DC, Sancar A. Domainal evolution of a prokaryotic DNA repair protein and its relationship to active-transport proteins Nature. 323: 451-453. PMID 3762695 DOI: 10.1038/323451A0  1
1986 Doolittle RF, Feng DF, Johnson MS, McClure MA. Relationships of human protein sequences to those of other organisms Cold Spring Harbor Symposia On Quantitative Biology. 51: 447-455. PMID 3472734 DOI: 10.1101/Sqb.1986.051.01.054  1
1986 Attardi G, Chomyn A, Doolittle RF, Mariottini P, Ragan CI. Seven unidentified reading frames of human mitochondrial DNA encode subunits of the respiratory chain NADH dehydrogenase. Cold Spring Harbor Symposia On Quantitative Biology. 51: 103-14. PMID 3472707 DOI: 10.1101/Sqb.1986.051.01.013  1
1986 Mariottini P, Chomyn A, Riley M, Cottrell B, Doolittle RF, Attardi G. Identification of the polypeptides encoded in the unassigned reading frames 2, 4, 4L, and 5 of human mitochondrial DNA. Proceedings of the National Academy of Sciences of the United States of America. 83: 1563-7. PMID 3456601 DOI: 10.1073/Pnas.83.6.1563  1
1986 Johnson MS, Doolittle RF. A method for the simultaneous alignment of three or more amino acid sequences Journal of Molecular Evolution. 23: 267-278. PMID 3100815 DOI: 10.1007/Bf02115583  1
1986 Fong HKW, Hurley JB, Hopkins RS, Miake-Lye R, Johnson MS, Doolittle RF, Simon MI. Repetitive segmental structure of the transducin β subunit: Homology with the CDC4 gene and identification of related mRNAs Proceedings of the National Academy of Sciences of the United States of America. 83: 2162-2166. PMID 3083416 DOI: 10.1073/Pnas.83.7.2162  1
1986 Johnson MS, McClure MA, Feng DF, Gray J, Doolittle RF. Computer analysis of retroviral pol genes: Assignment of enzymatic functions to specific sequences and homologies with nonviral enzymes Proceedings of the National Academy of Sciences of the United States of America. 83: 7648-7652. PMID 2429313 DOI: 10.1073/Pnas.83.20.7648  1
1986 Mariottini P, Chomyn A, Doolittle RF, Attardi G. Antibodies against the COOH-terminal undecapeptide of subunit II, but not those against the NH2-terminal decapeptide, immunoprecipitate the whole human cytochrome c oxidase complex. The Journal of Biological Chemistry. 261: 3355-62. PMID 2419330  1
1985 Feng DF, Johnson MS, Doolittle RF. Aligning amino acid sequences: Comparison of commonly used methods Journal of Molecular Evolution. 21: 112-125. PMID 6100188 DOI: 10.1007/Bf02100085  1
1985 Doolittle RF. Proteins Scientific American. 253: 88-99. PMID 4071032  1
1985 Doolittle RF. More homologies among the vertebrate plasma proteins Bioscience Reports. 5: 877-884. PMID 3938299 DOI: 10.1007/Bf01119899  1
1985 Chomyn A, Mariottini P, Cleeter MW, Ragan CI, Matsuno-Yagi A, Hatefi Y, Doolittle RF, Attardi G. Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase. Nature. 314: 592-7. PMID 3921850 DOI: 10.1038/314592A0  1
1985 Hearst JE, Alberti M, Doolittle RF. A putative nitrogenase reductase gene found in the nucleotide sequences from the photosynthetic gene cluster of R. capsulata. Cell. 40: 219-20. PMID 3855387 DOI: 10.1016/0092-8674(85)90325-3  1
1985 Strong DD, Moore M, Cottrell BA, Bohonus VL, Pontes M, Evans B, Riley M, Doolittle RF. Lamprey fibrinogen γ chain: Cloning, cDNA sequencing, and general characterization Biochemistry. 24: 92-101. PMID 2581603 DOI: 10.1021/Bi00322A014  1
1985 Jue RA, Doolittle RF. Determination of the relative positions of amino acids by partial specific cleavages of end-labeled proteins Biochemistry. 24: 162-170. DOI: 10.1021/Bi00322A023  1
1985 Doolittle RF. The genealogy of some recently evolved vertebrate proteins Trends in Biochemical Sciences. 10: 233-237. DOI: 10.1016/0968-0004(85)90140-9  1
1985 Evans BR, Watt KWK, Doolittle RF. Characterization and amino-terminal sequence of lamprey transferrin Federation Proceedings. 44: 3799.  1
1985 Pontes MC, Graham DL, Strong DD, Doolittle RF. Screening a lamprey liver cDNA library with oligonucleotide probes based on various plasma proteins Federation Proceedings. 44: 3798.  1
1984 Doolittle RF, Feng DF, Johnson MS. Computer-based characterization of epidermal growth factor precursor Nature. 307: 558-560. PMID 6607417 DOI: 10.1038/307558A0  1
1984 Peterson TA, Yochem J, Byers B, Nunn MF, Duesberg PH, Doolittle RF, Reed SI. A relationship between the yeast cell cycle genes CDC4 and CDC36 and the ets sequence of oncogenic virus E26. Nature. 309: 556-8. PMID 6374468 DOI: 10.1038/309556A0  1
1984 Horwich AL, Fenton WA, Williams KR, Kalousek F, Kraus JP, Doolittle RF, Konigsberg W, Rosenberg LE. Structure and expression of a complementary DNA for the nuclear coded precursor of human mitochondrial ornithine transcarbamylase. Science (New York, N.Y.). 224: 1068-74. PMID 6372096 DOI: 10.1126/Science.6372096  1
1984 Doolittle RF. Protein evolution: Modern proteins with ancient roots Federation Proceedings. 43: no. 1477.  1
1983 Hoeprich PD, Doolittle RF. Dimeric half-molecules of human fibrinogen are joined through disulfide bonds in an antiparallel orientation Biochemistry. 22: 2049-2055. PMID 6860649 DOI: 10.1021/Bi00278A003  1
1983 Doolittle RF. Angiotensinogen is related to the antitrypsin-antithrombin-ovalbumin family Science. 222: 417-419. PMID 6604942 DOI: 10.1126/Science.6604942  1
1983 Laudano AP, Cottrell BA, Doolittle RF. Synthetic peptides modeled on fibrin polymerization sites Annals of the New York Academy of Sciences. 315-329. PMID 6575692 DOI: 10.1111/J.1749-6632.1983.Tb23254.X  1
1983 Doolittle RF. Fibrinogen and fibrin Annual Review of Biochemistry. 195-229. PMID 6383194 DOI: 10.1146/Annurev.Bi.53.070184.001211  1
1983 Doolittle RF, Hunkapiller MW, Hood LE, Devare SG, Robbins KC, Aaronson SA, Antoniades HN. Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor Science. 221: 275-277. PMID 6304883 DOI: 10.1126/Science.6304883  1
1983 Mariottini P, Chomyn A, Attardi G, Trovato D, Strong DD, Doolittle RF. Antibodies against synthetic peptides reveal that the unidentified reading frame A6L, overlapping the ATPase 6 gene, is expressed in human mitochondria. Cell. 32: 1269-77. PMID 6301689 DOI: 10.1016/0092-8674(83)90308-2  1
1983 Chomyn A, Mariottini P, Gonzalez-Cadavid N, Attardi G, Strong DD, Trovato D, Riley M, Doolittle RF. Identification of the polypeptides encoded in the ATPase 6 gene and in the unassigned reading frames 1 and 3 of human mtDNA. Proceedings of the National Academy of Sciences of the United States of America. 80: 5535-9. PMID 6225122 DOI: 10.1073/Pnas.80.18.5535  1
1982 Kyte J, Doolittle RF. A simple method for displaying the hydropathic character of a protein Journal of Molecular Biology. 157: 105-132. PMID 7108955 DOI: 10.1016/0022-2836(82)90515-0  1
1982 Strong DD, Laudano AP, Hawiger J, Doolittle RF. Isolation, characterization, and synthesis of peptides from human fibrinogen that block the staphylococcal clumping reaction and construction of a synthetic clumping particle Biochemistry. 21: 1414-1420. PMID 7074096 DOI: 10.1021/Bi00535A048  1
1982 Hawiger J, Timmons S, Strong DD, Cottrell BA, Riley M, Doolittle RF. Identification of a region of human fibrinogen interacting with staphylococcal clumping factor Biochemistry. 21: 1407-1413. PMID 7074095  1
1982 Brown JP, Hewick RM, Hellström I, Hellström KE, Doolittle RF, Dreyer WJ. Human melanoma-associated antigen p97 is structurally and functionally related to transferrin. Nature. 296: 171-3. PMID 7063021 DOI: 10.1038/296171A0  1
1982 Doolittle RF, Woodbury NW, Jue RA. Ribosomal protein S1 is the product of a series of contiguous duplications Bioscience Reports. 2: 405-412. PMID 7049263 DOI: 10.1007/Bf01119303  1
1982 Sauer RT, Yocum RR, Doolittle RF, Lewis M, Pabo CO. Homology among DNA-binding proteins suggests use of a conserved super-secondary structure. Nature. 298: 447-51. PMID 6896364 DOI: 10.1038/298447A0  1
1982 Rose JK, Doolittle RF, Anilionis A, Curtis PJ, Wunner WH. Homology between the glycoproteins of vesicular stomatitis virus and rabies virus. Journal of Virology. 43: 361-4. PMID 6287013 DOI: 10.1128/jvi.43.1.361-364.1982  1
1982 Hawiger J, Timmons S, Kloczewiak M, Strong DD, Doolittle RF. γ and α chains of human fibrinogen possess sites reactive with human platelet receptors Proceedings of the National Academy of Sciences of the United States of America. 79: 2068-2071. PMID 6281794 DOI: 10.1073/Pnas.79.6.2068  1
1981 Doolittle RF. Similar amino acid sequences: Chance or common ancestry? Science. 214: 149-159. PMID 7280687 DOI: 10.1126/Science.7280687  1
1981 Laudano AP, Doolittle RF. Influence of calcium ion on the binding of fibrin amino terminal peptides to fibrinogen Science. 212: 457-459. PMID 7209542 DOI: 10.1126/Science.7209542  1
1981 Price TM, Strong DD, Rudee ML, Doolittle RF. Shadow-cast electron microscopy of fibrinogen with antibody fragments bound to specific regions. Proceedings of the National Academy of Sciences of the United States of America. 78: 200-4. PMID 6941244 DOI: 10.1073/Pnas.78.1.200  1
1981 Olexa SA, Budzynski AZ, Doolittle RF, Cottrell BA, Greene TC. Structure of fragment E species from human cross-linked fibrin. Biochemistry. 20: 6139-45. PMID 6458323 DOI: 10.1021/Bi00524A035  1
1981 Van Beveren C, Galleshaw JA, Jonas V, Berns AJ, Doolittle RF, Donoghue DJ, Verma IM. Nucleotide sequence and formation of the transforming gene of a mouse sarcoma virus. Nature. 289: 258-62. PMID 6256659 DOI: 10.1038/289258A0  1
1980 Jue RA, Woodbury NW, Doolittle RF. Sequence homologies among E. coli ribosomal proteins: Evidence for evolutionarily related groupings and internal duplications Journal of Molecular Evolution. 15: 129-148. PMID 6995620 DOI: 10.1007/Bf01732666  1
1980 Walter G, Scheidtmann KH, Carbone A, Laudano AP, Doolittle RF. Antibodies specific for the carboxy- and amino-terminal regions of simian virus 40 large tumor antigen Proceedings of the National Academy of Sciences of the United States of America. 77: 5197-5200. PMID 6254066 DOI: 10.1073/Pnas.77.9.5197  1
1980 Simon M, Zieg J, Silverman M, Mandel G, Doolittle R. Phase variation: evolution of a controlling element. Science (New York, N.Y.). 209: 1370-4. PMID 6251543 DOI: 10.1126/Science.6251543  1
1979 Watt KWK, Cottrell BA, Strong DD, Doolittle RF. Amino acid sequence studies on the α chain of human fibrinogen. Overlapping sequences providing the complete sequence Biochemistry. 18: 5410-5416. PMID 518846 DOI: 10.1021/Bi00591A024  1
1979 Cottrell BA, Strong DD, Watt KWK, Doolittle RF. Amino acid sequence studies on the α chain of human fibrinogen. exact location of cross-linking acceptor sites Biochemistry. 18: 5405-5410. PMID 518845 DOI: 10.1021/Bi00591A023  1
1979 Strong DD, Watt KWK, Cottrell BA, Doolittle RF. Amino acid sequence studies on the α chain of human fibrinogen. complete sequence of the largest cyanogen bromide fragment Biochemistry. 18: 5399-5404. PMID 518844 DOI: 10.1021/Bi00591A022  1
1979 Doolittle RF, Watt KWK, Cottrell BA, Strong DD, Riley M. The amino acid sequence of the α-chain of human fibrinogen Nature. 280: 464-468. PMID 460425 DOI: 10.1038/280464A0  1
1977 Doolittle LR, Mross GA, Fothergill LA, Doolittle RF. A simple solid-phase amino acid sequencer employing a thioacetylation stepwise degradation procedure Analytical Biochemistry. 78: 491-505. PMID 851221 DOI: 10.1016/0003-2697(77)90109-9  1
1975 Gaulton GN, Doolittle RF. Amino-terminal analysis of human fibrinogen treated with estrogenic steroids: Failure to support a thrombin-mimetic proteolytic effect Thrombosis Research. 7: 789-795. PMID 1209562 DOI: 10.1016/0049-3848(75)90203-0  1
1972 Doolittle RF, Fuller GM. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis studies on lobster fibrinogen and fibrin Bba - Protein Structure. 263: 805-809. PMID 5034221 DOI: 10.1016/0005-2795(72)90064-5  1
1971 Fuller GM, Doolittle RF. Studies of invertebrate fibrinogen. II. Transformation of lobster fibrinogen into fibrin Biochemistry. 10: 1311-1315. PMID 5580652 DOI: 10.1021/Bi00784A006  1
1971 Fuller GM, Doolittle RF. Studies of invertebrate fibrinogen. I. Purification and characterization of fibrinogen from the spiny lobster Biochemistry. 10: 135-1311. PMID 5580651 DOI: 10.1021/Bi00784A005  1
1967 Doolittle RF, Fuller GM. Quantitative determination of amino-terminal amino acids in crosslinked and non-crosslinked fibrin Biochemical and Biophysical Research Communications. 26: 327-333. PMID 6034356 DOI: 10.1016/0006-291X(67)90126-X  1
1967 Doolittle RF, Schubert D, Schwartz SA. Amino acid sequence studies on artiodactyl fibrinopeptides. I. Dromedary camel, mule deer, and cape buffalo Archives of Biochemistry and Biophysics. 118: 456-467. PMID 6033721 DOI: 10.1016/0003-9861(67)90374-8  1
1962 Doolittle RF, Oncley JL, Surgenor DM. Species differences in the interaction of thrombin and fibrinogen. The Journal of Biological Chemistry. 237: 3123-7. PMID 22103031  1
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