Liang Tong - Publications

Affiliations: 
Columbia University, New York, NY 
Area:
Structural Molecular Biology
Website:
http://www.columbia.edu/cu/biology/faculty-data/liang-tong/faculty.html

243 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Ranjan B, Choi PH, Pillai S, Permaul K, Tong L, Singh S. Crystal structure of a thermophilic fungal cyanase and its implications on the catalytic mechanism for bioremediation. Scientific Reports. 11: 277. PMID 33431973 DOI: 10.1038/s41598-020-79489-3  0.396
2020 Peterson BN, Young MKM, Luo S, Wang J, Whiteley AT, Woodward JJ, Tong L, Wang JD, Portnoy DA. (p)ppGpp and c-di-AMP Homeostasis Is Controlled by CbpB in Listeria monocytogenes. Mbio. 11. PMID 32843560 DOI: 10.1128/Mbio.01625-20  0.349
2020 Yang XC, Sun Y, Aik WS, Marzluff WF, Tong L, Dominski Z. Studies with recombinant U7 snRNP demonstrate that CPSF73 is both an endonuclease and a 5'-3' exonuclease. Rna (New York, N.Y.). PMID 32554553 DOI: 10.1261/Rna.076273.120  0.356
2020 Sharma S, Grudzien-Nogalska E, Hamilton K, Jiao X, Yang J, Tong L, Kiledjian M. Mammalian Nudix proteins cleave nucleotide metabolite caps on RNAs. Nucleic Acids Research. PMID 32432673 DOI: 10.1093/Nar/Gkaa402  0.391
2020 Doamekpor SK, Grudzien-Nogalska E, Mlynarska-Cieslak A, Kowalska J, Kiledjian M, Tong L. DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs. Nucleic Acids Research. PMID 32374864 DOI: 10.1093/Nar/Gkaa297  0.388
2020 Sun Y, Zhang Y, Aik WS, Yang XC, Marzluff WF, Walz T, Dominski Z, Tong L. Structure of an active human histone pre-mRNA 3'-end processing machinery. Science (New York, N.Y.). 367: 700-703. PMID 32029631 DOI: 10.1126/Science.Aaz7758  0.344
2020 Jernigan RJ, Nagaratnam N, Thifault D, Delker S, Zacks M, Edwards T, Sambucetti L, Tong L, Fromme R, Schneider J, Hsieh J, Mroczkowski B, Flint A, Fromme P, Garcia JM. New Structural Insights into the Function of the Active Full Length Human Taspase1: A Novel Anticancer Therapeutic Target Biophysical Journal. 118: 42a. DOI: 10.1016/J.Bpj.2019.11.410  0.324
2019 Bucholc K, Aik WS, Yang XC, Wang K, Zhou ZH, Dadlez M, Marzluff WF, Tong L, Dominski Z. Composition and processing activity of a semi-recombinant holo U7 snRNP. Nucleic Acids Research. PMID 31819999 DOI: 10.1093/Nar/Gkz1148  0.301
2019 Zhang Y, Sun Y, Shi Y, Walz T, Tong L. Structural Insights into the Human Pre-mRNA 3'-End Processing Machinery. Molecular Cell. PMID 31810758 DOI: 10.1016/J.Molcel.2019.11.005  0.325
2019 Grime GW, Zeldin O, Snell ME, Lowe ED, Hunt JF, Montelione GT, Tong L, Snell EH, Garman EF. High-throughput PIXE as an essential quantitative assay for accurate metalloprotein structural analysis; development and application. Journal of the American Chemical Society. PMID 31794207 DOI: 10.2210/Pdb6Oe2/Pdb  0.321
2019 Zhang Y, Chun Y, Buratowski S, Tong L. Identification of Three Sequence Motifs in the Transcription Termination Factor Sen1 that Mediate Direct Interactions with Nrd1. Structure (London, England : 1993). PMID 31104813 DOI: 10.2210/Pdb6O3Y/Pdb  0.335
2019 Grudzien-Nogalska E, Wu Y, Jiao X, Cui H, Mateyak MK, Hart RP, Tong L, Kiledjian M. Structural and mechanistic basis of mammalian Nudt12 RNA deNADding. Nature Chemical Biology. 15: 575-582. PMID 31101919 DOI: 10.1038/S41589-019-0293-7  0.384
2019 Kwasnik A, Wang VY, Krzyszton M, Gozdek A, Zakrzewska-Placzek M, Stepniak K, Poznanski J, Tong L, Kufel J. Arabidopsis DXO1 links RNA turnover and chloroplast function independently of its enzymatic activity. Nucleic Acids Research. PMID 30949699 DOI: 10.1093/Nar/Gkz100  0.634
2019 Kwasnik A, Wang VY, Krzyszton M, Gozdek A, Zakrzewska-Placzek M, Stepniak K, Poznanski J, Tong L, Kufel J. Arabidopsis DXO1 links RNA turnover and chloroplast function independently of its enzymatic activity. Nucleic Acids Research. PMID 30949693 DOI: 10.1093/nar/gkz257  0.588
2019 Wei J, Leit S, Kuai J, Therrien E, Rafi S, Harwood HJ, DeLaBarre B, Tong L. An allosteric mechanism for potent inhibition of human ATP-citrate lyase. Nature. PMID 30944472 DOI: 10.1038/S41586-019-1094-6  0.407
2019 Wei J, Leit S, Kuai J, Therrien E, Rafi S, Harwood Jr HJ, DeLaBarre B, Tong L. Cryo-EM structure of human ATP-citrate lyase in complex with a potent inhibitor Acta Crystallographica Section a Foundations and Advances. 75: a371-a371. DOI: 10.1107/S0108767319096387  0.359
2019 Garcia JM, Nagaratnam N, Jernigan R, Ketawala G, Delker S, Edwards T, Mendez D, Li C, Zatsepin N, Fromme R, Tong L, Schneider J, Hsieh J, Flint A, Fromme P. Structure Determination of Active Full Length Human Taspase1: Towards Novel Anti-Cancer Therapeutics Biophysical Journal. 116: 17a. DOI: 10.1016/J.Bpj.2018.11.135  0.301
2018 Luo S, Xu K, Xiang S, Chen J, Chen C, Guo C, Tong Y, Tong L. High-resolution structures of inhibitor complexes of human indoleamine 2,3-dioxygenase 1 in a new crystal form. Acta Crystallographica. Section F, Structural Biology Communications. 74: 717-724. PMID 30387777 DOI: 10.1107/S2053230X18012955  0.444
2018 Yun JS, Yoon JH, Choi YJ, Son YJ, Kim S, Tong L, Chang JH. Molecular mechanism for the inhibition of DXO by adenosine 3',5'-bisphosphate. Biochemical and Biophysical Research Communications. PMID 30180947 DOI: 10.1016/J.Bbrc.2018.08.135  0.43
2018 Albrecht TR, Shevtsov SP, Wu Y, Mascibroda LG, Peart NJ, Huang KL, Sawyer IA, Tong L, Dundr M, Wagner EJ. Integrator subunit 4 is a 'Symplekin-like' scaffold that associates with INTS9/11 to form the Integrator cleavage module. Nucleic Acids Research. PMID 29471365 DOI: 10.1093/Nar/Gky100  0.359
2018 Luo S, Tong L. Structural biology of the separase-securin complex with crucial roles in chromosome segregation. Current Opinion in Structural Biology. 49: 114-122. PMID 29452922 DOI: 10.1016/J.Sbi.2018.01.012  0.389
2017 Moremen KW, Ramiah A, Stuart M, Steel J, Meng L, Forouhar F, Moniz HA, Gahlay G, Gao Z, Chapla D, Wang S, Yang JY, Prabhakar PK, Johnson R, Rosa MD, ... ... Tong L, et al. Expression system for structural and functional studies of human glycosylation enzymes. Nature Chemical Biology. PMID 29251719 DOI: 10.1038/Nchembio.2539  0.396
2017 Sun Y, Zhang Y, Hamilton K, Manley JL, Shi Y, Walz T, Tong L. Molecular basis for the recognition of the human AAUAAA polyadenylation signal. Proceedings of the National Academy of Sciences of the United States of America. PMID 29208711 DOI: 10.1073/Pnas.1718723115  0.302
2017 Aik WS, Lin MH, Tan D, Tripathy A, Marzluff WF, Dominski Z, Chou CY, Tong L. The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3'-end processing. Plos One. 12: e0186034. PMID 29020104 DOI: 10.1371/Journal.Pone.0186034  0.569
2017 Choi PH, Vu TMN, Pham HT, Woodward JJ, Turner MS, Tong L. Structural and functional studies of pyruvate carboxylase regulation by cyclic di-AMP in lactic acid bacteria. Proceedings of the National Academy of Sciences of the United States of America. PMID 28808024 DOI: 10.1073/Pnas.1704756114  0.418
2017 Maderbocus R, Fields BL, Hamilton K, Luo S, Tran TH, Dietrich LEP, Tong L. Crystal structure of a Pseudomonas malonate decarboxylase holoenzyme hetero-tetramer. Nature Communications. 8: 160. PMID 28757619 DOI: 10.1038/S41467-017-00233-Z  0.449
2017 Wu Y, Albrecht TR, Baillat D, Wagner EJ, Tong L. Molecular basis for the interaction between Integrator subunits IntS9 and IntS11 and its functional importance. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396433 DOI: 10.1073/Pnas.1616605114  0.394
2017 McFarland AP, Luo S, Ahmed-Qadri F, Zuck M, Thayer EF, Goo YA, Hybiske K, Tong L, Woodward JJ. Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State. Immunity. 46: 433-445. PMID 28329705 DOI: 10.1016/J.Immuni.2017.02.014  0.315
2017 Jiao X, Doamekpor SK, Bird JG, Nickels BE, Tong L, Hart RP, Kiledjian M. 5' End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding. Cell. 168: 1015-1027.e10. PMID 28283058 DOI: 10.1016/J.Cell.2017.02.019  0.302
2017 Zhang Y, Shan CM, Wang J, Bao K, Tong L, Jia S. Molecular basis for the role of oncogenic histone mutations in modulating H3K36 methylation. Scientific Reports. 7: 43906. PMID 28256625 DOI: 10.1038/Srep43906  0.361
2017 Welsch ME, Kaplan A, Chambers JM, Stokes ME, Bos PH, Zask A, Zhang Y, Sanchez-Martin M, Badgley MA, Huang CS, Tran TH, Akkiraju H, Brown LM, Nandakumar R, Cremers S, ... ... Tong L, et al. Multivalent Small-Molecule Pan-RAS Inhibitors. Cell. 168: 878-889.e29. PMID 28235199 DOI: 10.1016/J.Cell.2017.02.006  0.504
2017 Luo S, Tong L. Molecular mechanism for the regulation of yeast separase by securin. Nature. PMID 28146474 DOI: 10.1038/Nature21061  0.483
2017 Zhu Y, Luo S, Sabo Y, Wang C, Tong L, Goff SP. Heme Oxygenase 2 Binds Myristate to Regulate Retrovirus Assembly and TLR4 Signaling. Cell Host & Microbe. PMID 28132836 DOI: 10.1016/J.Chom.2017.01.002  0.329
2017 Li M, Zhang WK, Benvin NM, Zhou X, Su D, Li H, Wang S, Michailidis IE, Tong L, Li X, Yang J. Structural basis of dual Ca(2+)/pH regulation of the endolysosomal TRPML1 channel. Nature Structural & Molecular Biology. PMID 28112729 DOI: 10.1038/Nsmb.3362  0.343
2017 Wei J, Zhang Y, Yu TY, Sadre-Bazzaz K, Rudolph MJ, Amodeo GA, Symington LS, Walz T, Tong L. Erratum: A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation. Cell Discovery. 3: 16055. PMID 28101377 DOI: 10.1038/celldisc.2016.55  0.765
2017 Whiteley AT, Garelis NE, Peterson BN, Choi PH, Tong L, Woodward JJ, Portnoy DA. c-di-AMP modulates Listeria monocytogenes central metabolism to regulate growth, antibiotic resistance, and osmoregulation. Molecular Microbiology. PMID 28097715 DOI: 10.1111/Mmi.13622  0.325
2016 Wei J, Zhang Y, Yu TY, Sadre-Bazzaz K, Rudolph MJ, Amodeo GA, Symington LS, Walz T, Tong L. A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation. Cell Discovery. 2: 16044. PMID 27990296 DOI: 10.1038/Celldisc.2016.44  0.817
2016 Liu Z, Gutierrez-Vargas C, Wei J, Grassucci RA, Ramesh M, Espina N, Sun M, Tutuncuoglu B, Madison-Antenucci S, Woolford JL, Tong L, Frank J. Structure and assembly model for the Trypanosoma cruzi 60S ribosomal subunit. Proceedings of the National Academy of Sciences of the United States of America. 113: 12174-12179. PMID 27791004 DOI: 10.1073/Pnas.1614594113  0.38
2016 Lewis-Ballester A, Forouhar F, Kim SM, Lew S, Wang Y, Karkashon S, Seetharaman J, Batabyal D, Chiang BY, Hussain M, Correia MA, Yeh SR, Tong L. Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase. Scientific Reports. 6: 35169. PMID 27762317 DOI: 10.1038/Srep35169  0.426
2016 Liu Z, Gutierrez-Vargas C, Wei J, Grassucci RA, Espina N, Madison-Antenucci S, Tong L, Frank J. Determination of the ribosome structure to a resolution of 2.5 Å by single-particle cryo-EM. Protein Science : a Publication of the Protein Society. PMID 27750394 DOI: 10.1002/Pro.3068  0.318
2016 Choi PH, Jo J, Lin YC, Lin MH, Chou CY, Dietrich LE, Tong L. A distinct holoenzyme organization for two-subunit pyruvate carboxylase. Nature Communications. 7: 12713. PMID 27708276 DOI: 10.1038/Ncomms12713  0.425
2016 Shan CM, Wang J, Xu K, Chen H, Yue JX, Andrews S, Moresco JJ, Yates JR, Nagy PL, Tong L, Jia S. A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading. Elife. 5. PMID 27648579 DOI: 10.7554/Elife.17903  0.302
2016 Zhang Y, Rataj K, Simpson GG, Tong L. Crystal Structure of the SPOC Domain of the Arabidopsis Flowering Regulator FPA. Plos One. 11: e0160694. PMID 27513867 DOI: 10.1371/Journal.Pone.0160694  0.413
2016 Huynh TN, Choi PH, Sureka K, Ledvina HE, Campillo J, Tong L, Woodward JJ. Cyclic di-AMP targets the cystathionine beta-synthase domain of the osmolyte transporter OpuC. Molecular Microbiology. PMID 27378384 DOI: 10.1111/Mmi.13456  0.333
2016 Sansó M, Levin RS, Lipp JJ, Wang VY, Greifenberg AK, Quezada EM, Ali A, Ghosh A, Larochelle S, Rana TM, Geyer M, Tong L, Shokat KM, Fisher RP. P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates. Genes & Development. 30: 117-31. PMID 26728557 DOI: 10.1101/Gad.269589.115  0.655
2015 Jurado AR, Huang CS, Zhang X, Zhou ZH, Tong L. Structure and substrate selectivity of the 750-kDa α6β6 holoenzyme of geranyl-CoA carboxylase. Nature Communications. 6: 8986. PMID 26593090 DOI: 10.1038/Ncomms9986  0.58
2015 Wei J, Tong L. Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer. Nature. 526: 723-7. PMID 26458104 DOI: 10.1038/Nature15375  0.467
2015 Everett J, Tejero R, Murthy SB, Acton TB, Aramini JM, Baran MC, Benach J, Cort JR, Eletsky A, Forouhar F, Guan R, Kuzin AP, Lee HW, Liu G, Mani R, ... ... Tong L, et al. A Community Resource of Experimental Data for NMR - X-ray Crystal Structure Pairs. Protein Science : a Publication of the Protein Society. PMID 26293815 DOI: 10.1002/Pro.2774  0.333
2015 Mompeán M, Hervás R, Xu Y, Tran TH, Guarnaccia C, Buratti E, Baralle F, Tong L, Carrión-Vázquez M, McDermott AE, Laurents DV. Structural Evidence of Amyloid Fibril Formation in the Putative Aggregation Domain of TDP-43. The Journal of Physical Chemistry Letters. 6: 2608-15. PMID 26266742 DOI: 10.1021/Acs.Jpclett.5B00918  0.32
2015 Aramini JM, Vorobiev SM, Tuberty LM, Janjua H, Campbell ET, Seetharaman J, Su M, Huang YJ, Acton TB, Xiao R, Tong L, Montelione GT. The RAS-Binding Domain of Human BRAF Protein Serine/Threonine Kinase Exhibits Allosteric Conformational Changes upon Binding HRAS. Structure (London, England : 1993). 23: 1382-93. PMID 26165597 DOI: 10.1016/J.Str.2015.06.003  0.396
2015 Wang VY, Jiao X, Kiledjian M, Tong L. Structural and biochemical studies of the distinct activity profiles of Rai1 enzymes. Nucleic Acids Research. PMID 26101253 DOI: 10.1093/Nar/Gkv620  0.694
2015 Webb BA, Forouhar F, Szu FE, Seetharaman J, Tong L, Barber DL. Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations. Nature. PMID 25985179 DOI: 10.1038/Nature14405  0.415
2015 Huynh TN, Luo S, Pensinger D, Sauer JD, Tong L, Woodward JJ. An HD-domain phosphodiesterase mediates cooperative hydrolysis of c-di-AMP to affect bacterial growth and virulence. Proceedings of the National Academy of Sciences of the United States of America. 112: E747-56. PMID 25583510 DOI: 10.1073/Pnas.1416485112  0.319
2015 Tran TH, Hsiao YS, Jo J, Chou CY, Dietrich LE, Walz T, Tong L. Structure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase. Nature. 518: 120-4. PMID 25383525 DOI: 10.1038/Nature13912  0.649
2014 Lohman DC, Forouhar F, Beebe ET, Stefely MS, Minogue CE, Ulbrich A, Stefely JA, Sukumar S, Luna-Sánchez M, Jochem A, Lew S, Seetharaman J, Xiao R, Wang H, Westphall MS, ... ... Tong L, et al. Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 111: E4697-705. PMID 25339443 DOI: 10.1073/Pnas.1413128111  0.411
2014 Sureka K, Choi PH, Precit M, Delince M, Pensinger DA, Huynh TN, Jurado AR, Goo YA, Sadilek M, Iavarone AT, Sauer JD, Tong L, Woodward JJ. The cyclic dinucleotide c-di-AMP is an allosteric regulator of metabolic enzyme function. Cell. 158: 1389-401. PMID 25215494 DOI: 10.1016/J.Cell.2014.07.046  0.353
2014 Elshahawi SI, Ramelot TA, Seetharaman J, Chen J, Singh S, Yang Y, Pederson K, Kharel MK, Xiao R, Lew S, Yennamalli RM, Miller MD, Wang F, Tong L, Montelione GT, et al. Structure-guided functional characterization of enediyne self-sacrifice resistance proteins, CalU16 and CalU19. Acs Chemical Biology. 9: 2347-58. PMID 25079510 DOI: 10.1021/Cb500327M  0.336
2014 Tan D, Zhou M, Kiledjian M, Tong L. The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA. Nature Structural & Molecular Biology. 21: 679-85. PMID 25026078 DOI: 10.1038/Nsmb.2857  0.55
2014 Wilson WC, Hornig-Do HT, Bruni F, Chang JH, Jourdain AA, Martinou JC, Falkenberg M, Spåhr H, Larsson NG, Lewis RJ, Hewitt L, Baslé A, Cross HE, Tong L, Lebel RR, et al. A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression. Human Molecular Genetics. 23: 6345-55. PMID 25008111 DOI: 10.1093/Hmg/Ddu352  0.322
2014 Zhang J, Tan D, DeRose EF, Perera L, Dominski Z, Marzluff WF, Tong L, Hall TM. Molecular mechanisms for the regulation of histone mRNA stem-loop-binding protein by phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 111: E2937-46. PMID 25002523 DOI: 10.1073/Pnas.1406381111  0.573
2014 Lasso G, Yu LP, Gil D, Lázaro M, Tong L, Valle M. Functional conformations for pyruvate carboxylase during catalysis explored by cryoelectron microscopy. Structure (London, England : 1993). 22: 911-22. PMID 24882745 DOI: 10.1016/J.Str.2014.04.011  0.612
2014 Wang R, Rajagopalan K, Sadre-Bazzaz K, Moreau M, Klessig DF, Tong L. Structure of the Arabidopsis thaliana TOP2 oligopeptidase. Acta Crystallographica. Section F, Structural Biology Communications. 70: 555-9. PMID 24817709 DOI: 10.1107/S2053230X14006128  0.441
2014 Yang X, Xu M, Wang Y, Xia P, Wang S, Ye B, Tong L, Jiang T, Fan Z. Molecular mechanism for self-protection against the type VI secretion system in Vibrio cholerae. Acta Crystallographica. Section D, Biological Crystallography. 70: 1094-103. PMID 24699653 DOI: 10.1107/S1399004714001242  0.416
2014 Jurado AR, Tan D, Jiao X, Kiledjian M, Tong L. Structure and function of pre-mRNA 5'-end capping quality control and 3'-end processing. Biochemistry. 53: 1882-98. PMID 24617759 DOI: 10.1021/Bi401715V  0.558
2014 Xiang K, Tong L, Manley JL. Delineating the structural blueprint of the pre-mRNA 3'-end processing machinery. Molecular and Cellular Biology. 34: 1894-910. PMID 24591651 DOI: 10.1128/Mcb.00084-14  0.344
2014 Srinivasan B, Forouhar F, Shukla A, Sampangi C, Kulkarni S, Abashidze M, Seetharaman J, Lew S, Mao L, Acton TB, Xiao R, Everett JK, Montelione GT, Tong L, Balaram H. Allosteric regulation and substrate activation in cytosolic nucleotidase II from Legionella pneumophila. The Febs Journal. 281: 1613-28. PMID 24456211 DOI: 10.1111/Febs.12727  0.383
2014 Vorobiev SM, Gensler Y, Vahedian-Movahed H, Seetharaman J, Su M, Huang JY, Xiao R, Kornhaber G, Montelione GT, Tong L, Ebright RH, Nickels BE. Structure of the DNA-binding and RNA-polymerase-binding region of transcription antitermination factor λQ. Structure (London, England : 1993). 22: 488-95. PMID 24440517 DOI: 10.1016/J.Str.2013.12.010  0.353
2014 Bjelic S, Kipnis Y, Wang L, Pianowski Z, Vorobiev S, Su M, Seetharaman J, Xiao R, Kornhaber G, Hunt JF, Tong L, Hilvert D, Baker D. Exploration of alternate catalytic mechanisms and optimization strategies for retroaldolase design. Journal of Molecular Biology. 426: 256-71. PMID 24161950 DOI: 10.1016/J.Jmb.2013.10.012  0.308
2013 Meng L, Forouhar F, Thieker D, Gao Z, Ramiah A, Moniz H, Xiang Y, Seetharaman J, Milaninia S, Su M, Bridger R, Veillon L, Azadi P, Kornhaber G, Wells L, ... ... Tong L, et al. Enzymatic basis for N-glycan sialylation: structure of rat α2,6-sialyltransferase (ST6GAL1) reveals conserved and unique features for glycan sialylation. The Journal of Biological Chemistry. 288: 34680-98. PMID 24155237 DOI: 10.1074/Jbc.M113.519041  0.474
2013 Xu SY, Kuzin AP, Seetharaman J, Gutjahr A, Chan SH, Chen Y, Xiao R, Acton TB, Montelione GT, Tong L. Structure determination and biochemical characterization of a putative HNH endonuclease from Geobacter metallireducens GS-15. Plos One. 8: e72114. PMID 24039739 DOI: 10.1371/Journal.Pone.0072114  0.453
2013 Yang H, Zhang T, Tao Y, Wang F, Tong L, Ding J. Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair. Nucleic Acids Research. 41: 10573-83. PMID 24003026 DOI: 10.1093/Nar/Gkt788  0.382
2013 Neklesa TK, Noblin DJ, Kuzin A, Lew S, Seetharaman J, Acton TB, Kornhaber G, Xiao R, Montelione GT, Tong L, Crews CM. A bidirectional system for the dynamic small molecule control of intracellular fusion proteins. Acs Chemical Biology. 8: 2293-300. PMID 23978068 DOI: 10.1021/Cb400569K  0.308
2013 Mills JH, Khare SD, Bolduc JM, Forouhar F, Mulligan VK, Lew S, Seetharaman J, Tong L, Stoddard BL, Baker D. Computational design of an unnatural amino acid dependent metalloprotein with atomic level accuracy. Journal of the American Chemical Society. 135: 13393-9. PMID 23924187 DOI: 10.1021/Ja403503M  0.336
2013 Catalano J, Sadre-Bazzaz K, Amodeo GA, Tong L, McDermott A. Structural evidence: a single charged residue affects substrate binding in cytochrome P450 BM-3. Biochemistry. 52: 6807-15. PMID 23829560 DOI: 10.1021/Bi4000645  0.806
2013 Procko E, Hedman R, Hamilton K, Seetharaman J, Fleishman SJ, Su M, Aramini J, Kornhaber G, Hunt JF, Tong L, Montelione GT, Baker D. Computational design of a protein-based enzyme inhibitor. Journal of Molecular Biology. 425: 3563-75. PMID 23827138 DOI: 10.1016/J.Jmb.2013.06.035  0.359
2013 Froese DS, Forouhar F, Tran TH, Vollmar M, Kim YS, Lew S, Neely H, Seetharaman J, Shen Y, Xiao R, Acton TB, Everett JK, Cannone G, Puranik S, Savitsky P, ... ... Tong L, et al. Crystal structures of malonyl-coenzyme A decarboxylase provide insights into its catalytic mechanism and disease-causing mutations. Structure (London, England : 1993). 21: 1182-92. PMID 23791943 DOI: 10.1016/J.Str.2013.05.001  0.458
2013 Tan D, Crabb WM, Whitman WB, Tong L. Crystal structure of DmdD, a crotonase superfamily enzyme that catalyzes the hydration and hydrolysis of methylthioacryloyl-CoA. Plos One. 8: e63870. PMID 23704947 DOI: 10.1371/Journal.Pone.0063870  0.647
2013 Jiao X, Chang JH, Kilic T, Tong L, Kiledjian M. A mammalian pre-mRNA 5' end capping quality control mechanism and an unexpected link of capping to pre-mRNA processing. Molecular Cell. 50: 104-15. PMID 23523372 DOI: 10.1016/J.Molcel.2013.02.017  0.323
2013 Tan D, Marzluff WF, Dominski Z, Tong L. Structure of histone mRNA stem-loop, human stem-loop binding protein, and 3'hExo ternary complex. Science (New York, N.Y.). 339: 318-21. PMID 23329046 DOI: 10.1126/Science.1228705  0.578
2013 Yu LP, Chou CY, Choi PH, Tong L. Characterizing the importance of the biotin carboxylase domain dimer for Staphylococcus aureus pyruvate carboxylase catalysis. Biochemistry. 52: 488-96. PMID 23286247 DOI: 10.1021/Bi301294D  0.629
2013 Wang L, Li Q, Wu L, Liu S, Zhang Y, Yang X, Zhu P, Zhang H, Zhang K, Lou J, Liu P, Tong L, Sun F, Fan Z. Identification of SERPINB1 as a physiological inhibitor of human granzyme H. Journal of Immunology (Baltimore, Md. : 1950). 190: 1319-30. PMID 23269243 DOI: 10.4049/Jimmunol.1202542  0.407
2013 Tong L. Structure and function of biotin-dependent carboxylases. Cellular and Molecular Life Sciences : Cmls. 70: 863-91. PMID 22869039 DOI: 10.1007/S00018-012-1096-0  0.426
2012 Chang JH, Xiang S, Tong L. Structures of 5'-3' Exoribonucleases. The Enzymes. 31: 115-29. PMID 27166443 DOI: 10.1016/B978-0-12-404740-2.00006-9  0.393
2012 Yu Y, Ulbrich MH, Li MH, Dobbins S, Zhang WK, Tong L, Isacoff EY, Yang J. Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex. Nature Communications. 3: 1252. PMID 23212381 DOI: 10.1038/Ncomms2257  0.316
2012 Xiang K, Manley JL, Tong L. An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72. Genes & Development. 26: 2265-70. PMID 23070812 DOI: 10.1101/Gad.198853.112  0.367
2012 Chang JH, Jiao X, Chiba K, Oh C, Martin CE, Kiledjian M, Tong L. Dxo1 is a new type of eukaryotic enzyme with both decapping and 5'-3' exoribonuclease activity. Nature Structural & Molecular Biology. 19: 1011-7. PMID 22961381 DOI: 10.1038/Nsmb.2381  0.419
2012 Richter F, Blomberg R, Khare SD, Kiss G, Kuzin AP, Smith AJ, Gallaher J, Pianowski Z, Helgeson RC, Grjasnow A, Xiao R, Seetharaman J, Su M, Vorobiev S, Lew S, ... ... Tong L, et al. Computational design of catalytic dyads and oxyanion holes for ester hydrolysis. Journal of the American Chemical Society. 134: 16197-206. PMID 22871159 DOI: 10.1021/Ja3037367  0.366
2012 Feldmann EA, Seetharaman J, Ramelot TA, Lew S, Zhao L, Hamilton K, Ciccosanti C, Xiao R, Acton TB, Everett JK, Tong L, Montelione GT, Kennedy MA. Solution NMR and X-ray crystal structures of Pseudomonas syringae Pspto_3016 from protein domain family PF04237 (DUF419) adopt a "double wing" DNA binding motif. Journal of Structural and Functional Genomics. 13: 155-62. PMID 22865330 DOI: 10.1007/S10969-012-9140-8  0.393
2012 Swapna GV, Rossi P, Montelione AF, Benach J, Yu B, Abashidze M, Seetharaman J, Xiao R, Acton TB, Tong L, Montelione GT. Three structural representatives of the PF06855 protein domain family from Staphyloccocus aureus and Bacillus subtilis have SAM domain-like folds and different functions. Journal of Structural and Functional Genomics. 13: 163-70. PMID 22843344 DOI: 10.1007/S10969-012-9134-6  0.374
2012 Xiang K, Manley JL, Tong L. The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity. Nature Communications. 3: 946. PMID 22781759 DOI: 10.1038/Ncomms1947  0.436
2012 Paulson AR, Tong L. Crystal structure of the Rna14-Rna15 complex. Rna (New York, N.Y.). 18: 1154-62. PMID 22513198 DOI: 10.1261/Rna.032524.112  0.598
2012 Fan C, Chou CY, Tong L, Xiang S. Crystal structure of urea carboxylase provides insights into the carboxyltransfer reaction. The Journal of Biological Chemistry. 287: 9389-98. PMID 22277658 DOI: 10.1074/Jbc.M111.319475  0.465
2012 Huang CS, Ge P, Zhou ZH, Tong L. An unanticipated architecture of the 750-kDa α6β6 holoenzyme of 3-methylcrotonyl-CoA carboxylase. Nature. 481: 219-23. PMID 22158123 DOI: 10.1038/Nature10691  0.617
2012 Wang L, Zhang K, Wu L, Liu S, Zhang H, Zhou Q, Tong L, Sun F, Fan Z. Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif. Journal of Immunology (Baltimore, Md. : 1950). 188: 765-73. PMID 22156497 DOI: 10.4049/Jimmunol.1101381  0.434
2012 Wang L, Guo H, Reyes N, Lee S, Bortz E, Guo F, Sun R, Tong L, Deng H. Distinct domains in ORF52 tegument protein mediate essential functions in murine gammaherpesvirus 68 virion tegumentation and secondary envelopment. Journal of Virology. 86: 1348-57. PMID 22090138 DOI: 10.1128/Jvi.05497-11  0.367
2012 Vorobiev SM, Huang YJ, Seetharaman J, Xiao R, Acton TB, Montelione GT, Tong L. Human retinoblastoma binding protein 9, a serine hydrolase implicated in pancreatic cancers. Protein and Peptide Letters. 19: 194-7. PMID 21933118 DOI: 10.2174/092986612799080356  0.368
2012 Yu Y, Ulbrich MH, Dobbins S, Li M, Zhang WK, Tong L, Isacoff EY, Yang J. Molecular and Structural Mechanism of the Assembly of an Acid-Sensing Receptor/Ion Channel Complex Biophysical Journal. 102: 345a. DOI: 10.1016/J.Bpj.2011.11.1889  0.353
2011 Aksyuk AA, Kurochkina LP, Fokine A, Forouhar F, Mesyanzhinov VV, Tong L, Rossmann MG. Structural conservation of the myoviridae phage tail sheath protein fold. Structure (London, England : 1993). 19: 1885-94. PMID 22153511 DOI: 10.1016/J.Str.2011.09.012  0.802
2011 Ni S, McGookey ME, Tinch SL, Jones AN, Jayaraman S, Tong L, Kennedy MA. The 1.7 Å resolution structure of At2g44920, a pentapeptide-repeat protein in the thylakoid lumen of Arabidopsis thaliana. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 1480-4. PMID 22139148 DOI: 10.1107/S1744309111037432  0.392
2011 Forouhar F, Saadat N, Hussain M, Seetharaman J, Lee I, Janjua H, Xiao R, Shastry R, Acton TB, Montelione GT, Tong L. A large conformational change in the putative ATP pyrophosphatase PF0828 induced by ATP binding. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 67: 1323-7. PMID 22102225 DOI: 10.1107/S1744309111031447  0.429
2011 Kryshtafovych A, Moult J, Bartual SG, Bazan JF, Berman H, Casteel DE, Christodoulou E, Everett JK, Hausmann J, Heidebrecht T, Hills T, Hui R, Hunt JF, Seetharaman J, Joachimiak A, ... ... Tong L, et al. Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction. Proteins. 79: 6-20. PMID 22020785 DOI: 10.1002/Prot.23196  0.389
2011 Lowery J, Szul T, Seetharaman J, Jian X, Su M, Forouhar F, Xiao R, Acton TB, Montelione GT, Lin H, Wright JW, Lee E, Holloway ZG, Randazzo PA, Tong L, et al. Novel C-terminal motif within Sec7 domain of guanine nucleotide exchange factors regulates ADP-ribosylation factor (ARF) binding and activation. The Journal of Biological Chemistry. 286: 36898-906. PMID 21828055 DOI: 10.1074/Jbc.M111.230631  0.4
2011 Zhang H, Constantine R, Vorobiev S, Chen Y, Seetharaman J, Huang YJ, Xiao R, Montelione GT, Gerstner CD, Davis MW, Inana G, Whitby FG, Jorgensen EM, Hill CP, Tong L, et al. UNC119 is required for G protein trafficking in sensory neurons. Nature Neuroscience. 14: 874-80. PMID 21642972 DOI: 10.1038/Nn.2835  0.338
2011 Huang KY, Amodeo GA, Tong L, McDermott A. The structure of human ubiquitin in 2-methyl-2,4-pentanediol: a new conformational switch. Protein Science : a Publication of the Protein Society. 20: 630-9. PMID 21432937 DOI: 10.1002/Pro.584  0.803
2011 Chang JH, Xiang S, Xiang K, Manley JL, Tong L. Structural and biochemical studies of the 5'→3' exoribonuclease Xrn1. Nature Structural & Molecular Biology. 18: 270-6. PMID 21297639 DOI: 10.1038/Nsmb.1984  0.449
2011 Bai Y, Srivastava SK, Chang JH, Manley JL, Tong L. Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase. Molecular Cell. 41: 311-20. PMID 21292163 DOI: 10.1016/J.Molcel.2011.01.013  0.58
2011 Barb AW, Cort JR, Seetharaman J, Lew S, Lee HW, Acton T, Xiao R, Kennedy MA, Tong L, Montelione GT, Prestegard JH. Structures of domains I and IV from YbbR are representative of a widely distributed protein family. Protein Science : a Publication of the Protein Society. 20: 396-405. PMID 21154411 DOI: 10.1002/Pro.571  0.393
2011 Huang CS, Ge P, Zhou ZH, Tong L. An unanticipated architecture of the 750-kDa {alpha}6{beta}6 holoenzyme of 3-methylcrotonyl-CoA carboxylase Nature. 481: 219-223. DOI: 10.2210/Pdb3U9R/Pdb  0.455
2011 Tong L, Khayat R. Diseases caused by papillomavirus Xpharm: the Comprehensive Pharmacology Reference. 1-2. DOI: 10.1016/B978-008055232-3.60921-3  0.433
2011 Tong L, Khayat R. Cytomegaloviral (CMV) disease Xpharm: the Comprehensive Pharmacology Reference. 1-3. DOI: 10.1016/B978-008055232-3.60919-5  0.427
2011 Khayat R, Tong L. Epstein-barr virus infections Xpharm: the Comprehensive Pharmacology Reference. 1-3. DOI: 10.1016/B978-008055232-3.60916-X  0.429
2011 Khayat R, Tong L. Herpes simplex infections Xpharm: the Comprehensive Pharmacology Reference. 1-3. DOI: 10.1016/B978-008055232-3.60915-8  0.427
2010 Forouhar F, Lew S, Seetharaman J, Xiao R, Acton TB, Montelione GT, Tong L. Structures of bacterial biosynthetic arginine decarboxylases. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 1562-6. PMID 21139196 DOI: 10.1107/S1744309110040649  0.452
2010 Yu LP, Kim YS, Tong L. Mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by pinoxaden. Proceedings of the National Academy of Sciences of the United States of America. 107: 22072-7. PMID 21135213 DOI: 10.1073/Pnas.1012039107  0.651
2010 Lasso G, Yu LP, Gil D, Xiang S, Tong L, Valle M. Cryo-EM analysis reveals new insights into the mechanism of action of pyruvate carboxylase. Structure (London, England : 1993). 18: 1300-10. PMID 20947019 DOI: 10.1016/J.Str.2010.07.008  0.581
2010 Xiang K, Nagaike T, Xiang S, Kilic T, Beh MM, Manley JL, Tong L. Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Nature. 467: 729-33. PMID 20861839 DOI: 10.1038/Nature09391  0.449
2010 Rudolph MJ, Amodeo GA, Tong L. An inhibited conformation for the protein kinase domain of the Saccharomyces cerevisiae AMPK homolog Snf1. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 999-1002. PMID 20823513 DOI: 10.1107/S1744309110028265  0.818
2010 Jiao X, Xiang S, Oh C, Martin CE, Tong L, Kiledjian M. Identification of a quality-control mechanism for mRNA 5'-end capping. Nature. 467: 608-11. PMID 20802481 DOI: 10.1038/Nature09338  0.31
2010 Huang CS, Sadre-Bazzaz K, Shen Y, Deng B, Zhou ZH, Tong L. Crystal structure of the alpha(6)beta(6) holoenzyme of propionyl-coenzyme A carboxylase. Nature. 466: 1001-5. PMID 20725044 DOI: 10.1038/Nature09302  0.579
2010 Amodeo GA, Momcilovic M, Carlson M, Tong L. Biochemical and functional studies on the regulation of the Saccharomyces cerevisiae AMPK homolog SNF1. Biochemical and Biophysical Research Communications. 397: 197-201. PMID 20529674 DOI: 10.1016/J.Bbrc.2010.05.083  0.799
2010 Corbett JW, Freeman-Cook KD, Elliott R, Vajdos F, Rajamohan F, Kohls D, Marr E, Zhang H, Tong L, Tu M, Murdande S, Doran SD, Houser JA, Song W, Jones CJ, et al. Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2. Bioorganic & Medicinal Chemistry Letters. 20: 2383-8. PMID 20219367 DOI: 10.1016/J.Bmcl.2009.04.091  0.342
2010 Seetharaman J, Neely H, Wang D, Janjua H, Cunningham K, Owens L, Xiao R, Liu J, Baran MC, Acton TB, Montelione GT, Tong L, Hunt JF. Solution NMR Structure of DRBM 2 domain of Interleukin enhancer-binding factor 3 from Homo sapiens, Northeast Structural Genomics Consortium Target HR4527E Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2L33/Pdb  0.356
2010 Li M, He L, Buraei Z, Yu Y, Tong L, Yang J. Molecular and Structural Basis of Dual Regulation of a Canonical TRP Channel by Calmodulin Biophysical Journal. 98: 343a. DOI: 10.1016/J.Bpj.2009.12.1859  0.308
2009 Xiang S, Callaghan MM, Watson KG, Tong L. A different mechanism for the inhibition of the carboxyltransferase domain of acetyl-coenzyme A carboxylase by tepraloxydim. Proceedings of the National Academy of Sciences of the United States of America. 106: 20723-7. PMID 19926852 DOI: 10.1073/Pnas.0908431106  0.456
2009 Yu Y, Ulbrich MH, Li MH, Buraei Z, Chen XZ, Ong AC, Tong L, Isacoff EY, Yang J. Structural and molecular basis of the assembly of the TRPP2/PKD1 complex. Proceedings of the National Academy of Sciences of the United States of America. 106: 11558-63. PMID 19556541 DOI: 10.1073/Pnas.0903684106  0.394
2009 Yu LP, Xiang S, Lasso G, Gil D, Valle M, Tong L. A symmetrical tetramer for S. aureus pyruvate carboxylase in complex with coenzyme A. Structure (London, England : 1993). 17: 823-32. PMID 19523900 DOI: 10.1016/J.Str.2009.04.008  0.655
2009 Hsiao YS, Parker D, Ratner AJ, Prince A, Tong L. Crystal structures of respiratory pathogen neuraminidases. Biochemical and Biophysical Research Communications. 380: 467-71. PMID 19284989 DOI: 10.1016/J.Bbrc.2009.01.108  0.64
2009 Chou CY, Yu LP, Tong L. Crystal structure of biotin carboxylase in complex with substrates and implications for its catalytic mechanism. The Journal of Biological Chemistry. 284: 11690-7. PMID 19213731 DOI: 10.1074/Jbc.M805783200  0.657
2009 Xiang S, Cooper-Morgan A, Jiao X, Kiledjian M, Manley JL, Tong L. Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Nature. 458: 784-8. PMID 19194460 DOI: 10.1038/Nature07731  0.37
2009 Bertonati C, Punta M, Fischer M, Yachdav G, Forouhar F, Zhou W, Kuzin AP, Seetharaman J, Abashidze M, Ramelot TA, Kennedy MA, Cort JR, Belachew A, Hunt JF, Tong L, et al. Structural genomics reveals EVE as a new ASCH/PUA-related domain. Proteins. 75: 760-73. PMID 19191354 DOI: 10.1002/Prot.22287  0.391
2009 Zhao N, Guan J, Forouhar F, Tschaplinski TJ, Cheng ZM, Tong L, Chen F. Two poplar methyl salicylate esterases display comparable biochemical properties but divergent expression patterns. Phytochemistry. 70: 32-9. PMID 19136124 DOI: 10.1016/J.Phytochem.2008.11.014  0.303
2009 Vorobiev SM, Su M, Seetharaman J, Huang YJ, Chen CX, Maglaqui M, Janjua H, Proudfoot M, Yakunin A, Xiao R, Acton TB, Montelione GT, Tong L. Crystal structure of human retinoblastoma binding protein 9. Proteins. 74: 526-9. PMID 19004028 DOI: 10.1002/Prot.22278  0.45
2008 Vila JA, Aramini JM, Rossi P, Kuzin A, Su M, Seetharaman J, Xiao R, Tong L, Montelione GT, Scheraga HA. Quantum chemical 13C(alpha) chemical shift calculations for protein NMR structure determination, refinement, and validation. Proceedings of the National Academy of Sciences of the United States of America. 105: 14389-94. PMID 18787110 DOI: 10.1073/Pnas.0807105105  0.329
2008 Thackray SJ, Bruckmann C, Anderson JL, Campbell LP, Xiao R, Zhao L, Mowat CG, Forouhar F, Tong L, Chapman SK. Histidine 55 of tryptophan 2,3-dioxygenase is not an active site base but regulates catalysis by controlling substrate binding. Biochemistry. 47: 10677-84. PMID 18783250 DOI: 10.1021/Bi801202A  0.409
2008 Huang YJ, Hang D, Lu LJ, Tong L, Gerstein MB, Montelione GT. Targeting the human cancer pathway protein interaction network by structural genomics. Molecular & Cellular Proteomics : McP. 7: 2048-60. PMID 18487680 DOI: 10.1074/mcp.M700550-MCP200  0.327
2008 Shen Y, Tong L. Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1. Biochemistry. 47: 5767-73. PMID 18452305 DOI: 10.1021/Bi800314M  0.392
2008 Xiang S, Tong L. Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction. Nature Structural & Molecular Biology. 15: 295-302. PMID 18297087 DOI: 10.1038/Nsmb.1393  0.435
2008 Forouhar F, Abashidze M, Xu H, Grochowski LL, Seetharaman J, Hussain M, Kuzin A, Chen Y, Zhou W, Xiao R, Acton TB, Montelione GT, Galinier A, White RH, Tong L. Molecular insights into the biosynthesis of the F420 coenzyme. The Journal of Biological Chemistry. 283: 11832-40. PMID 18252724 DOI: 10.1074/Jbc.M710352200  0.35
2008 Gräslund S, Nordlund P, Weigelt J, Hallberg BM, Bray J, Gileadi O, Knapp S, Oppermann U, Arrowsmith C, Hui R, Ming J, dhe-Paganon S, ... ... Tong L, et al. Protein production and purification. Nature Methods. 5: 135-46. PMID 18235434 DOI: 10.1038/Nmeth.F.202  0.511
2008 Mandel CR, Bai Y, Tong L. Protein factors in pre-mRNA 3'-end processing. Cellular and Molecular Life Sciences : Cmls. 65: 1099-122. PMID 18158581 DOI: 10.1007/S00018-007-7474-3  0.487
2008 Tong L, Xiang S, Mandel C, Bai Y, Manley J. Structural studies of pre-mRNA 3′-end processing Acta Crystallographica Section a Foundations of Crystallography. 64: C90-C90. DOI: 10.1107/S0108767308097092  0.477
2007 Amodeo GA, Rudolph MJ, Tong L. Crystal structure of the heterotrimer core of Saccharomyces cerevisiae AMPK homologue SNF1. Nature. 449: 492-5. PMID 17851534 DOI: 10.1038/Nature06127  0.82
2007 Benach J, Wang L, Chen Y, Ho CK, Lee S, Seetharaman J, Xiao R, Acton TB, Montelione GT, Deng H, Sun R, Tong L. Structural and functional studies of the abundant tegument protein ORF52 from murine gammaherpesvirus 68. The Journal of Biological Chemistry. 282: 31534-41. PMID 17699518 DOI: 10.1074/Jbc.M705637200  0.407
2007 Khan JA, Xiang S, Tong L. Crystal structure of human nicotinamide riboside kinase. Structure (London, England : 1993). 15: 1005-13. PMID 17698003 DOI: 10.1016/J.Str.2007.06.017  0.487
2007 Forouhar F, Kuzin A, Seetharaman J, Lee I, Zhou W, Abashidze M, Chen Y, Yong W, Janjua H, Fang Y, Wang D, Cunningham K, Xiao R, Acton TB, Pichersky E, ... ... Tong L, et al. Functional insights from structural genomics Journal of Structural and Functional Genomics. 8: 37-44. PMID 17588214 DOI: 10.1007/S10969-007-9018-3  0.405
2007 Li J, Mao X, Dong LQ, Liu F, Tong L. Crystal structures of the BAR-PH and PTB domains of human APPL1. Structure (London, England : 1993). 15: 525-33. PMID 17502098 DOI: 10.1016/J.Str.2007.03.011  0.349
2007 Yin C, Khan JA, Swapna GV, Ertekin A, Krug RM, Tong L, Montelione GT. Conserved surface features form the double-stranded RNA binding site of non-structural protein 1 (NS1) from influenza A and B viruses. The Journal of Biological Chemistry. 282: 20584-92. PMID 17475623 DOI: 10.1074/Jbc.M611619200  0.383
2007 Bai Y, Auperin TC, Chou CY, Chang GG, Manley JL, Tong L. Crystal structure of murine CstF-77: dimeric association and implications for polyadenylation of mRNA precursors. Molecular Cell. 25: 863-75. PMID 17386263 DOI: 10.1016/J.Molcel.2007.01.034  0.567
2007 Vorobiev SM, Neely H, Seetharaman J, Ma LC, Xiao R, Acton TB, Montelione GT, Tong L. Crystal structure of AGR_C_4470p from Agrobacterium tumefaciens. Protein Science : a Publication of the Protein Society. 16: 535-8. PMID 17322535 DOI: 10.1110/Ps.062663307  0.41
2007 Bai Y, Auperin TC, Tong L. The use of in situ proteolysis in the crystallization of murine CstF-77. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 63: 135-8. PMID 17277459 DOI: 10.1107/S1744309107002904  0.547
2007 Rudolph MJ, Amodeo GA, Iram SH, Hong SP, Pirino G, Carlson M, Tong L. Structure of the Bateman2 domain of yeast Snf4: dimeric association and relevance for AMP binding. Structure (London, England : 1993). 15: 65-74. PMID 17223533 DOI: 10.1016/J.Str.2006.11.014  0.824
2007 Forouhar F, Anderson JL, Mowat CG, Vorobiev SM, Hussain A, Abashidze M, Bruckmann C, Thackray SJ, Seetharaman J, Tucker T, Xiao R, Ma LC, Zhao L, Acton TB, Montelione GT, ... ... Tong L, et al. Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase. Proceedings of the National Academy of Sciences of the United States of America. 104: 473-8. PMID 17197414 DOI: 10.1073/Pnas.0610007104  0.425
2007 Xiang S, Usunow G, Lange G, Busch M, Tong L. Crystal structure of 1-deoxy-D-xylulose 5-phosphate synthase, a crucial enzyme for isoprenoids biosynthesis Journal of Biological Chemistry. 282: 2676-2682. PMID 17135236 DOI: 10.1074/Jbc.M610235200  0.482
2007 Rossi P, Ramelot T, Ciano M, Ho C, Ma L, Xiao R, Acton T, Kennedy M, Tong L, Montelione G. Solution NMR structure of human myeloid differentiation primary response (MyD88). Northeast Structural Genomics target HR2869A Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr15356  0.302
2006 Mandel CR, Kaneko S, Zhang H, Gebauer D, Vethantham V, Manley JL, Tong L. Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease. Nature. 444: 953-6. PMID 17128255 DOI: 10.1038/Nature05363  0.412
2006 Mandel CR, Gebauer D, Zhang H, Tong L. A serendipitous discovery that in situ proteolysis is essential for the crystallization of yeast CPSF-100 (Ydh1p). Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 1041-5. PMID 17012808 DOI: 10.1107/S1744309106038152  0.412
2006 Hsiao YS, Jogl G, Tong L. Crystal structures of murine carnitine acetyltransferase in ternary complexes with its substrates. The Journal of Biological Chemistry. 281: 28480-7. PMID 16870616 DOI: 10.1074/Jbc.M602622200  0.665
2006 Soong G, Muir A, Gomez MI, Waks J, Reddy B, Planet P, Singh PK, Kaneko Y, Kanetko Y, Wolfgang MC, Hsiao YS, Tong L, Prince A. Bacterial neuraminidase facilitates mucosal infection by participating in biofilm production. The Journal of Clinical Investigation. 116: 2297-2305. PMID 16862214 DOI: 10.1172/Jci27920  0.55
2006 Shen Y, Chou CY, Chang GG, Tong L. Is dimerization required for the catalytic activity of bacterial biotin carboxylase? Molecular Cell. 22: 807-18. PMID 16793549 DOI: 10.1016/J.Molcel.2006.04.026  0.457
2006 Hsiao YS, Jogl G, Esser V, Tong L. Crystal structure of rat carnitine palmitoyltransferase II (CPT-II). Biochemical and Biophysical Research Communications. 346: 974-80. PMID 16781677 DOI: 10.1016/J.Bbrc.2006.06.006  0.622
2006 Annedi SC, Biabani F, Poduch E, Mannargudi BM, Majumder K, Wei L, Khayat R, Tong L, Kotra LP. Engineering d-amino acid containing novel protease inhibitors using catalytic site architecture. Bioorganic & Medicinal Chemistry. 14: 214-36. PMID 16198572 DOI: 10.1016/J.Bmc.2005.08.019  0.61
2005 Rudolph MJ, Amodeo GA, Bai Y, Tong L. Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase Snf1. Biochemical and Biophysical Research Communications. 337: 1224-8. PMID 16236260 DOI: 10.1016/J.Bbrc.2005.09.181  0.808
2005 Khan JA, Dunn BM, Tong L. Crystal structure of human Taspase1, a crucial protease regulating the function of MLL. Structure (London, England : 1993). 13: 1443-52. PMID 16216576 DOI: 10.1016/J.Str.2005.07.006  0.431
2005 Forouhar F, Lee IS, Vujcic J, Vujcic S, Shen J, Vorobiev SM, Xiao R, Acton TB, Montelione GT, Porter CW, Tong L. Structural and functional evidence for Bacillus subtilis PaiA as a novel N1-spermidine/spermine acetyltransferase Journal of Biological Chemistry. 280: 40328-40336. PMID 16210326 DOI: 10.1074/Jbc.M505332200  0.446
2005 Tong L. Acetyl-coenzyme A carboxylase: Crucial metabolic enzyme and attractive target for drug discovery Cellular and Molecular Life Sciences. 62: 1784-1803. PMID 15968460 DOI: 10.1007/S00018-005-5121-4  0.379
2005 Forouhar F, Yang Y, Kumar D, Chen Y, Fridman E, Park SW, Chiang Y, Acton TB, Montelione GT, Pichersky E, Klessig DF, Tong L. Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity Proceedings of the National Academy of Sciences of the United States of America. 102: 1773-1778. PMID 15668381 DOI: 10.1073/Pnas.0409227102  0.407
2005 Jogl G, Hsiao YS, Tong L. Crystal structure of mouse carnitine octanoyltransferase and molecular determinants of substrate selectivity. The Journal of Biological Chemistry. 280: 738-44. PMID 15492013 DOI: 10.1074/Jbc.M409894200  0.669
2005 Zhang H, Tweel B, Li J, Tong L. Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase in complex with CP-640186. Structure (London, England : 1993). 12: 1683-91. PMID 15341732 DOI: 10.1016/J.Str.2004.07.009  0.399
2005 Harrop SJ, Helliwell JR, Wan TC, Kalb AJ, Tong L, Yariv J. Structure solution of a cubic crystal of concanavalin A complexed with methyl alpha-D-glucopyranoside. Acta Crystallographica. Section D, Biological Crystallography. 52: 143-55. PMID 15299735 DOI: 10.1107/S0907444995008742  0.371
2004 Shen Y, Volrath SL, Weatherly SC, Elich TD, Tong L. A mechanism for the potent inhibition of eukaryotic acetyl-coenzyme A carboxylase by soraphen A, a macrocyclic polyketide natural product. Molecular Cell. 16: 881-91. PMID 15610732 DOI: 10.1016/J.Molcel.2004.11.034  0.483
2004 Jogl G, Hsiao YS, Tong L. Structure and function of carnitine acyltransferases. Annals of the New York Academy of Sciences. 1033: 17-29. PMID 15591000 DOI: 10.1196/Annals.1320.002  0.681
2004 Gebauer D, Li J, Jogl G, Shen Y, Myszka DG, Tong L. Crystal structure of the PH-BEACH domains of human LRBA/BGL. Biochemistry. 43: 14873-80. PMID 15554694 DOI: 10.1021/Bi049498Y  0.365
2004 Blankenfeldt W, Kuzin AP, Skarina T, Korniyenko Y, Tong L, Bayer P, Janning P, Thomashow LS, Mavrodi DV. Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens. Proceedings of the National Academy of Sciences of the United States of America. 101: 16431-6. PMID 15545603 DOI: 10.1073/Pnas.0407371101  0.44
2004 Hsu WC, Hung HC, Tong L, Chang GG. Dual functional roles of ATP in the human mitochondrial malic enzyme. Biochemistry. 43: 7382-90. PMID 15182181 DOI: 10.1021/Bi049600R  0.417
2004 Chen YH, Li MH, Zhang Y, He LL, Yamada Y, Fitzmaurice A, Shen Y, Zhang H, Tong L, Yang J. Structural basis of the α1-β subunit interaction of voltage-gated Ca2+ channels Nature. 429: 675-680. PMID 15170217 DOI: 10.1038/Nature02641  0.335
2004 Hsiao YS, Jogl G, Tong L. Structural and biochemical studies of the substrate selectivity of carnitine acetyltransferase. The Journal of Biological Chemistry. 279: 31584-9. PMID 15155726 DOI: 10.1074/Jbc.M403484200  0.67
2004 Khan JA, Brint EK, O'Neill LA, Tong L. Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL. The Journal of Biological Chemistry. 279: 31664-70. PMID 15123616 DOI: 10.1074/Jbc.M403434200  0.319
2004 Zhang H, Tweel B, Tong L. Molecular basis for the inhibition of the carboxyltransferase domain of acetyl-coenzyme-A carboxylase by haloxyfop and diclofop Proceedings of the National Academy of Sciences of the United States of America. 101: 5910-5915. PMID 15079078 DOI: 10.1073/Pnas.0400891101  0.436
2004 Jogl G, Tong L. Crystal structure of yeast acetyl-coenzyme A synthetase in complex with AMP. Biochemistry. 43: 1425-31. PMID 14769018 DOI: 10.1021/Bi035911A  0.485
2004 Kuo CW, Hung HC, Tong L, Chang GG. Metal-Induced reversible structural interconversion of human mitochondrial NAD(P)+-dependent malic enzyme. Proteins. 54: 404-11. PMID 14747989 DOI: 10.1002/Prot.10635  0.423
2004 Forouhar F, Lee I, Benach J, Kulkarni K, Xiao R, Acton TB, Montelione GT, Tong L. A novel NAD-binding protein revealed by the crystal structure of 2,3-diketo-L-gulonate reductase (YiaK). The Journal of Biological Chemistry. 279: 13148-55. PMID 14718529 DOI: 10.1074/Jbc.M313580200  0.474
2004 Khayat R, Batra R, Bebernitz GA, Olson MW, Tong L. Characterization of the monomer-dimer equilibrium of human cytomegalovirus protease by kinetic methods. Biochemistry. 43: 316-22. PMID 14717585 DOI: 10.1021/Bi035170D  0.616
2004 Forouhar F, Shen J, Xiao R, Acton TB, Montelione GT, Tong L. Functional assignment based on structural analysis: crystal structure of the yggJ protein (HI0303) of Haemophilus influenzae reveals an RNA methyltransferase with a deep trefoil knot. Proteins. 53: 329-32. PMID 14517985 DOI: 10.1002/Prot.10510  0.322
2003 Chang GG, Tong L. Structure and function of malic enzymes, a new class of oxidative decarboxylases. Biochemistry. 42: 12721-33. PMID 14596586 DOI: 10.1021/Bi035251+  0.498
2003 Tao X, Yang Z, Tong L. Crystal structures of substrate complexes of malic enzyme and insights into the catalytic mechanism. Structure (London, England : 1993). 11: 1141-50. PMID 12962632 DOI: 10.1016/S0969-2126(03)00168-0  0.781
2003 Tao X, Khayat R, Christendat D, Savchenko A, Xu X, Goldsmith-Fischman S, Honig B, Edwards A, Arrowsmith CH, Tong L. Crystal structures of MTH1187 and its yeast ortholog YBL001c. Proteins. 52: 478-80. PMID 12866058 DOI: 10.1002/Prot.10443  0.61
2003 Zhang H, Yang Z, Shen Y, Tong L. Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase. Science (New York, N.Y.). 299: 2064-7. PMID 12663926 DOI: 10.1126/Science.1081366  0.789
2003 Khayat R, Batra R, Qian C, Halmos T, Bailey M, Tong L. Structural and biochemical studies of inhibitor binding to human cytomegalovirus protease. Biochemistry. 42: 885-91. PMID 12549906 DOI: 10.1021/Bi027045S  0.648
2003 Jogl G, Tong L. Crystal structure of carnitine acetyltransferase and implications for the catalytic mechanism and fatty acid transport. Cell. 112: 113-22. PMID 12526798 DOI: 10.1016/S0092-8674(02)01228-X  0.485
2003 Jogl G, Rozovsky S, McDermott AE, Tong L. Optimal alignment for enzymatic proton transfer: Structure of the Michaelis complex of triosephosphate isomerase at 1.2-Å resolution Proceedings of the National Academy of Sciences of the United States of America. 100: 50-55. PMID 12509510 DOI: 10.1073/Pnas.0233793100  0.37
2003 Yang Z, Savchenko A, Yakunin A, Zhang R, Edwards A, Arrowsmith C, Tong L. Aspartate dehydrogenase, a novel enzyme identified from structural and functional studies of TM1643. The Journal of Biological Chemistry. 278: 8804-8. PMID 12496312 DOI: 10.1074/Jbc.M211892200  0.802
2002 Tao X, Xu Y, Zheng Y, Beg AA, Tong L. An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2. Biochemical and Biophysical Research Communications. 299: 216-21. PMID 12437972 DOI: 10.1016/S0006-291X(02)02581-0  0.36
2002 Jogl G, Shen Y, Gebauer D, Li J, Wiegmann K, Kashkar H, Krönke M, Tong L. Crystal structure of the BEACH domain reveals an unusual fold and extensive association with a novel PH domain. The Embo Journal. 21: 4785-95. PMID 12234919 DOI: 10.1093/Emboj/Cdf502  0.4
2002 Batra R, Christendat D, Edwards A, Arrowsmith C, Tong L. Crystal structure of MTH169, a crucial component of phosphoribosylformylglycinamidine synthetase. Proteins. 49: 285-8. PMID 12211007 DOI: 10.1002/Prot.10209  0.368
2002 Yang Z, Lanks CW, Tong L. Molecular mechanism for the regulation of human mitochondrial NAD(P)+-dependent malic enzyme by ATP and fumarate. Structure (London, England : 1993). 10: 951-60. PMID 12121650 DOI: 10.1016/S0969-2126(02)00788-8  0.792
2002 Regan J, Breitfelder S, Cirillo P, Gilmore T, Graham AG, Hickey E, Klaus B, Madwed J, Moriak M, Moss N, Pargellis C, Pav S, Proto A, Swinamer A, Tong L, et al. Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate. Journal of Medicinal Chemistry. 45: 2994-3008. PMID 12086485 DOI: 10.1021/Jm020057R  0.375
2002 Pargellis C, Tong L, Churchill L, Cirillo PF, Gilmore T, Graham AG, Grob PM, Hickey ER, Moss N, Pav S, Regan J. Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. Nature Structural Biology. 9: 268-72. PMID 11896401 DOI: 10.1038/Nsb770  0.353
2002 Yang Z, Zhang H, Hung HC, Kuo CC, Tsai LC, Yuan HS, Chou WY, Chang GG, Tong L. Structural studies of the pigeon cytosolic NADP(+)-dependent malic enzyme. Protein Science : a Publication of the Protein Society. 11: 332-41. PMID 11790843 DOI: 10.1110/Ps.38002  0.786
2001 Rishavy MA, Yang Z, Tong L, Cleland WW. Determination of the mechanism of human malic enzyme with natural and alternate dinucleotides by isotope effects. Archives of Biochemistry and Biophysics. 396: 43-8. PMID 11716460 DOI: 10.1006/Abbi.2001.2598  0.746
2001 Tong L. How to take advantage of non-crystallographic symmetry in molecular replacement: 'Locked' rotation and translation functions Acta Crystallographica - Section D Biological Crystallography. 57: 1383-1389. PMID 11567149 DOI: 10.1107/S0907444901012446  0.349
2001 Batra R, Khayat R, Tong L. Molecular mechanism for dimerization to regulate the catalytic activity of human cytomegalovirus protease. Nature Structural Biology. 8: 810-7. PMID 11524687 DOI: 10.1038/Nsb0901-810  0.65
2001 Rozovsky S, Jogl G, Tong L, McDermott AE. Solution-state NMR investigations of triosephosphate isomerase active site loop motion: Ligand release in relation to active site loop dynamics Journal of Molecular Biology. 310: 271-280. PMID 11419952 DOI: 10.1006/Jmbi.2001.4673  0.341
2001 Last-Barney K, Davidson W, Cardozo M, Frye LL, Grygon CA, Hopkins JL, Jeanfavre DD, Pav S, Qian C, Stevenson JM, Tong L, Zindell R, Kelly TA. Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: evidence for the allosteric inhibition of a protein--protein interaction. Journal of the American Chemical Society. 123: 5643-50. PMID 11403595 DOI: 10.1021/Ja0104249  0.396
2001 Khayat R, Batra R, Massariol MJ, Lagacé L, Tong L. Investigating the role of histidine 157 in the catalytic activity of human cytomegalovirus protease. Biochemistry. 40: 6344-51. PMID 11371196 DOI: 10.1021/Bi010158B  0.649
2001 Shi D, Morizono H, Yu X, Tong L, Allewell NM, Tuchman M. Crystallization and preliminary X-ray crystallographic studies of wild-type human ornithine transcarbamylase and two naturally occurring mutants at position 277 Acta Crystallographica Section D: Biological Crystallography. 57: 719-721. PMID 11320316 DOI: 10.1107/S0907444901002803  0.354
2001 Shi D, Morizono H, Yu X, Tong L, Allewell NM, Tuchman M. Human ornithine transcarbamylase: Crystallographic insights into substrate recognition and conformational changes Biochemical Journal. 354: 501-509. PMID 11237854 DOI: 10.1042/0264-6021:3540501  0.458
2001 Batra R, Khayat R, Tong L. Structural studies of herpesvirus proteases Protein and Peptide Letters. 8: 333-342. DOI: 10.2174/0929866013409229  0.645
2000 Hung HC, Chang GG, Yang Z, Tong L. Slow binding of metal ions to pigeon liver malic enzyme: a general case. Biochemistry. 39: 14095-102. PMID 11087357 DOI: 10.1021/Bi001534F  0.771
2000 Xu Y, Tao X, Shen B, Horng T, Medzhitov R, Manley JL, Tong L. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature. 408: 111-5. PMID 11081518 DOI: 10.1038/35040600  0.312
2000 Yang Z, Batra R, Floyd DL, Hung HC, Chang GG, Tong L. Potent and competitive inhibition of malic enzymes by lanthanide ions. Biochemical and Biophysical Research Communications. 274: 440-4. PMID 10913357 DOI: 10.1006/Bbrc.2000.3163  0.783
2000 Chou WY, Chang HP, Huang CH, Kuo CC, Tong L, Chang GG. Characterization of the functional role of Asp141, Asp194, and Asp464 residues in the Mn2+-L-malate binding of pigeon liver malic enzyme. Protein Science : a Publication of the Protein Society. 9: 242-51. PMID 10716176 DOI: 10.1110/Ps.9.2.242  0.342
2000 Yang Z, Floyd DL, Loeber G, Tong L. Structure of a closed form of human malic enzyme and implications for catalytic mechanism. Nature Structural Biology. 7: 251-7. PMID 10700286 DOI: 10.1038/73378  0.796
1999 Wu H, Park YC, Ye H, Tong L. Structural studies of human TRAF2. Cold Spring Harbor Symposia On Quantitative Biology. 64: 541-550. PMID 11232331 DOI: 10.1101/Sqb.1999.64.541  0.325
1999 Bhargava G, Mui S, Pav S, Wu H, Loeber G, Tong L. Preliminary crystallographic studies of human mitochondrial NAD(P)(+)-dependent malic enzyme. Journal of Structural Biology. 127: 72-75. PMID 10479619 DOI: 10.1006/Jsbi.1999.4126  0.4
1999 Beaulieu PL, Cameron DR, Ferland JM, Gauthier J, Ghiro E, Gillard J, Gorys V, Poirier M, Rancourt J, Wernic D, Llinas-Brunet M, Betageri R, Cardozo M, Hickey ER, Ingraham R, ... ... Tong L, et al. Ligands for the tyrosine kinase p56lck SH2 domain: discovery of potent dipeptide derivatives with monocharged, nonhydrolyzable phosphate replacements. Journal of Medicinal Chemistry. 42: 1757-66. PMID 10346928 DOI: 10.1021/Jm980676T  0.37
1999 Park YC, Burkitt V, Villa AR, Tong L, Wu H. Structural basis for self-association and receptor recognition of human TRAF2. Nature. 398: 533-8. PMID 10206649 DOI: 10.1038/19110  0.365
1999 Xu Y, Bhargava G, Wu H, Loeber G, Tong L. Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme: a new class of oxidative decarboxylases Structure. 7: 877-889. DOI: 10.1016/S0969-2126(99)80115-4  0.482
1997 Tong L, Rossmann MG. [34] Rotation function calculations with GLRF program. Methods in Enzymology. 276: 594-611. PMID 27799117 DOI: 10.1016/S0076-6879(97)76080-4  0.491
1997 Tong L, Pav S, White DM, Rogers S, Crane KM, Cywin CL, Brown ML, Pargellis CA. A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket. Nature Structural Biology. 4: 311-6. PMID 9095200 DOI: 10.1038/Nsb0497-311  0.417
1997 Pav S, White DM, Rogers S, Crane KM, Cywin CL, Davidson W, Hopkins J, Brown ML, Pargellis CA, Tong L. Crystallization and preliminary crystallographic analysis of recombinant human P38 MAP kinase. Protein Science : a Publication of the Protein Society. 6: 242-5. PMID 9007996 DOI: 10.1002/Pro.5560060126  0.338
1997 Roth GP, Emmanuel M, Tong L. Resolution and assignment of the absolute stereochemistry of a trans-2,3-diarylpyrrolidine LTB4 inhibitor intermediate Tetrahedron-Asymmetry. 8: 185-186. DOI: 10.1016/S0957-4166(96)00512-5  0.319
1996 Momany C, Kovari LC, Prongay AJ, Keller W, Gitti RK, Lee BM, Gorbalenya AE, Tong L, McClure J, Ehrlich LS, Summers MF, Carter C, Rossmann MG. Crystal structure of dimeric HIV-1 capsid protein. Nature Structural Biology. 3: 763-70. PMID 8784350 DOI: 10.1038/Nsb0996-763  0.548
1995 Cornea-Hasegan MA, Zhang Z, Lynch RE, Marinescu DC, Hadfield A, Muckelbauer JK, Munshi S, Tong L, Rossmann MG. Phase refinement and extension by means of non-crystallographic symmetry averaging using parallel computers. Acta Crystallographica. Section D, Biological Crystallography. 51: 749-59. PMID 15299805 DOI: 10.1107/S0907444995001399  0.414
1995 Muckelbauer JK, Kremer M, Minor I, Tong L, Zlotnick A, Johnson JE, Rossmann MG. Structure determination of coxsackievirus B3 to 3.5 A resolution. Acta Crystallographica. Section D, Biological Crystallography. 51: 871-87. PMID 15299757 DOI: 10.1107/S0907444995002253  0.586
1995 Tong L, Rossmann MG. Reciprocal-space molecular-replacement averaging. Acta Crystallographica. Section D, Biological Crystallography. 51: 347-53. PMID 15299302 DOI: 10.1107/S0907444994010760  0.428
1995 Tong L, Pav S, Mui S, Lamarre D, Yoakim C, Beaulieu P, Anderson PC. Crystal structures of HIV-2 protease in complex with inhibitors containing the hydroxyethylamine dipeptide isostere. Structure (London, England : 1993). 3: 33-40. PMID 7743130 DOI: 10.1016/S0969-2126(01)00133-2  0.353
1995 Proudfoot JR, Hargrave KD, Kapadia SR, Patel UR, Grozinger KG, McNeil DW, Cullen E, Cardozo M, Tong L, Kelly TA. Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. 4. 2-Substituted dipyridodiazepinones as potent inhibitors of both wild-type and cysteine-181 HIV-1 reverse transcriptase enzymes. Journal of Medicinal Chemistry. 38: 4830-8. PMID 7490732 DOI: 10.1021/Jm00024A010  0.336
1993 Tong L, Wengler G, Rossmann MG. Refined structure of Sindbis virus core protein and comparison with other chymotrypsin-like serine proteinase structures. Journal of Molecular Biology. 230: 228-47. PMID 8450538 DOI: 10.1006/Jmbi.1993.1139  0.554
1993 Somoza JR, Jiang F, Tong L, Kang CH, Cho JM, Kim SH. Two crystal structures of a potently sweet protein. Natural monellin at 2.75 A resolution and single-chain monellin at 1.7 A resolution. Journal of Molecular Biology. 234: 390-404. PMID 8230222 DOI: 10.1006/Jmbi.1993.1594  0.608
1993 Bibler JK, Kremer M, Tong L, Rossmann MG. Crystallization and characterization of coxsackievirus B3 (CVB3) Acta Crystallographica Section a Foundations of Crystallography. 49: c66-c66. DOI: 10.1107/S0108767378098098  0.463
1993 Tong L, Rossmann MG. Patterson-map interpretation with noncrystallographic symmetry Journal of Applied Crystallography. 26: 15-21. DOI: 10.1107/S0021889892007295  0.477
1993 Tong L, Cardozo M, Jones P, Adams J. Preliminary structural analysis of the mutations selected by non-nucleoside inhibitors of HIV-1 reverse transcriptase Bioorganic & Medicinal Chemistry Letters. 3: 721-726. DOI: 10.1016/S0960-894X(01)81262-2  0.339
1992 Privé GG, Milburn MV, Tong L, de Vos AM, Yamaizumi Z, Nishimura S, Kim SH. X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis. Proceedings of the National Academy of Sciences of the United States of America. 89: 3649-53. PMID 1565661 DOI: 10.1073/Pnas.89.8.3649  0.728
1992 Tong L, Choi HK, Minor W, Rossmann MG. The structure determination of Sindbis virus core protein using isomorphous replacement and molecular replacement averaging between two crystal forms. Acta Crystallographica. Section a, Foundations of Crystallography. 48: 430-42. PMID 1418825 DOI: 10.1107/S0108767391014630  0.528
1992 Rossmann MG, McKenna R, Tong L, Xia D, Dai J, Wu H, Choi HK, Lynch RE. Molecular replacement real-space averaging Journal of Applied Crystallography. 25: 166-180. DOI: 10.1107/S002188989101141X  0.484
1991 Choi HK, Tong L, Minor W, Dumas P, Boege U, Rossmann MG, Wengler G. Structure of Sindbis virus core protein reveals a chymotrypsin-like serine proteinase and the organization of the virion. Nature. 354: 37-43. PMID 1944569 DOI: 10.1038/354037A0  0.545
1991 Tong LA, de Vos AM, Milburn MV, Kim SH. Crystal structures at 2.2 A resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP. Journal of Molecular Biology. 217: 503-16. PMID 1899707 DOI: 10.1016/0022-2836(91)90753-S  0.608
1990 Milburn MV, Tong L, deVos AM, Brünger A, Yamaizumi Z, Nishimura S, Kim SH. Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins. Science (New York, N.Y.). 247: 939-45. PMID 2406906 DOI: 10.1126/Science.2406906  0.602
1990 Brünger AT, Milburn MV, Tong L, deVos AM, Jancarik J, Yamaizumi Z, Nishimura S, Ohtsuka E, Kim SH. Crystal structure of an active form of RAS protein, a complex of a GTP analog and the HRAS p21 catalytic domain. Proceedings of the National Academy of Sciences of the United States of America. 87: 4849-53. PMID 2191303 DOI: 10.1073/Pnas.87.12.4849  0.626
1990 Tong LA, Rossmann MG. The locked rotation function. Acta Crystallographica. Section a, Foundations of Crystallography. 46: 783-92. PMID 2174243 DOI: 10.1016/0022-2836(72)90333-6  0.456
1989 Glaeser RM, Tong L, Kim SH. Three-dimensional reconstructions from incomplete data: interpretability of density maps at "atomic" resolution. Ultramicroscopy. 27: 307-18. PMID 2749922 DOI: 10.1016/0304-3991(89)90021-1  0.507
1989 Tong L, Milburn MV, de Vos AM, Kim SH. Structure of ras proteins. Science (New York, N.Y.). 245: 244. PMID 2665078 DOI: 10.1126/Science.2665078  0.516
1988 de Vos AM, Tong L, Milburn MV, Matias PM, Jancarik J, Noguchi S, Nishimura S, Miura K, Ohtsuka E, Kim SH. Three-dimensional structure of an oncogene protein: catalytic domain of human c-H-ras p21. Science (New York, N.Y.). 239: 888-93. PMID 2448879 DOI: 10.1126/Science.2448879  0.629
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