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Susan Serota Taylor - Publications

Affiliations: 
University of California, San Diego, La Jolla, CA 
Area:
Structure, Function, Dynamics, and Localization of PKA as a Prototype for the Protein Kinase Superfamily
Website:
http://www-chem.ucsd.edu/faculty/profiles/taylor_susan_s.html

297 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Palencia-Campos A, Aoto PC, Machal EMF, Rivera-Barahona A, Soto-Bielicka P, Bertinetti D, Baker B, Vu L, Piceci-Sparascio F, Torrente I, Boudin E, Peeters S, Van Hul W, Huber C, Bonneau D, ... ... Taylor SS, et al. Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome. American Journal of Human Genetics. PMID 33058759 DOI: 10.1016/j.ajhg.2020.09.005  0.44
2020 Zhang JZ, Lu TW, Stolerman LM, Tenner B, Yang JR, Zhang JF, Falcke M, Rangamani P, Taylor SS, Mehta S, Zhang J. Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling. Cell. PMID 32846158 DOI: 10.1016/j.cell.2020.07.043  0.36
2020 Olivieri C, Wang Y, Li GC, Subrahmanian MV, Kim J, Stultz BR, Neibergall M, Porcelli F, Muretta JM, T Thomas DD, Gao J, Blumenthal DK, Taylor SS, Veglia G. Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A. Elife. 9. PMID 32338601 DOI: 10.7554/eLife.55607  0.44
2020 Gerlits O, Weiss KL, Blakeley MP, Veglia G, Taylor SS, Kovalevsky A. Protein kinase A in the neutron beam: Insights for catalysis from directly observing protons. Methods in Enzymology. 634: 311-331. PMID 32093838 DOI: 10.1016/bs.mie.2019.12.003  0.44
2019 Haushalter KJ, Schilling JM, Song Y, Sastri M, Perkins GA, Strack S, Taylor SS, Patel HH. Cardiac ischemia/reperfusion injury induces ROS-dependent loss of PKA regulatory subunit RIα. American Journal of Physiology. Heart and Circulatory Physiology. PMID 31674811 DOI: 10.1152/ajpheart.00237.2019  0.44
2019 Walker C, Wang Y, Olivieri C, Karamafrooz A, Casby J, Bathon K, Calebiro D, Gao J, Bernlohr DA, Taylor SS, Veglia G. Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity. Science Advances. 5: eaaw9298. PMID 31489371 DOI: 10.1126/sciadv.aaw9298  0.44
2019 Lu TW, Wu J, Aoto PC, Weng JH, Ahuja LG, Sun N, Cheng CY, Zhang P, Taylor SS. Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP. Proceedings of the National Academy of Sciences of the United States of America. PMID 31363049 DOI: 10.1073/pnas.1906036116  0.44
2019 Schmidt SH, Knape MJ, Boassa D, Mumdey N, Kornev AP, Ellisman MH, Taylor SS, Herberg FW. The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain. Proceedings of the National Academy of Sciences of the United States of America. PMID 31292254 DOI: 10.1073/pnas.1900289116  0.72
2019 Ahuja LG, Aoto PC, Kornev AP, Veglia G, Taylor SS. Dynamic allostery-based molecular workings of kinase:peptide complexes. Proceedings of the National Academy of Sciences of the United States of America. PMID 31285328 DOI: 10.1073/pnas.1900163116  0.72
2019 Ahuja LG, Taylor SS, Kornev AP. Tuning the "violin" of protein kinases: The role of dynamics-based allostery. Iubmb Life. PMID 31063633 DOI: 10.1002/iub.2057  0.72
2019 Taylor SS, Meharena HS, Kornev AP. Evolution of a Dynamic Molecular Switch. Iubmb Life. PMID 31059206 DOI: 10.1002/iub.2059  0.72
2019 Gerlits O, Weiss KL, Blakeley MP, Veglia G, Taylor SS, Kovalevsky A. Zooming in on protons: Neutron structure of protein kinase A trapped in a product complex. Science Advances. 5: eaav0482. PMID 30906862 DOI: 10.1126/sciadv.aav0482  0.44
2019 Cao B, Lu TW, Martinez Fiesco JA, Tomasini M, Fan L, Simon SM, Taylor SS, Zhang P. Structures of the PKA RIα Holoenzyme with the FLHCC Driver J-PKAcα or Wild-Type PKAcα. Structure (London, England : 1993). PMID 30905674 DOI: 10.1016/j.str.2019.03.001  0.36
2019 Wang Y, V S M, Kim J, Li G, Ahuja LG, Aoto P, Taylor SS, Veglia G. Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase's enzymatic cycle. Nature Communications. 10: 799. PMID 30778078 DOI: 10.1038/s41467-019-08655-7  0.44
2019 Zhang P, Fan Y, Ru H, Wang L, Magupalli VG, Taylor SS, Alessi DR, Wu H. Crystal structure of the WD40 domain dimer of LRRK2. Proceedings of the National Academy of Sciences of the United States of America. PMID 30635421 DOI: 10.1073/pnas.1817889116  0.36
2019 Gógl G, Kornev AP, Reményi A, Taylor SS. Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores. Trends in Biochemical Sciences. PMID 30611608 DOI: 10.1016/j.tibs.2018.12.002  0.72
2018 Meng Y, Ahuja LG, Kornev AP, Taylor SS, Roux B. Corrigendum to "A Catalytically-Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation." J. Mol. Biol. 430(6) (Mar 16 2018), 881-889. Journal of Molecular Biology. PMID 30220583 DOI: 10.1016/j.jmb.2018.09.001  0.72
2018 Meng Y, Ahuja LG, Kornev AP, Taylor SS, Roux B. A Catalytically-Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation. Journal of Molecular Biology. PMID 29410316 DOI: 10.1016/j.jmb.2018.01.019  0.72
2018 Tomasini MD, Wang Y, Karamafrooz A, Li G, Beuming T, Gao J, Taylor SS, Veglia G, Simon SM. Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma. Scientific Reports. 8: 720. PMID 29335433 DOI: 10.1038/s41598-017-18956-w  0.44
2017 Bubis J, Martínez JC, Calabokis M, Ferreira J, Sanz-Rodríguez CE, Navas V, Escalona JL, Guo Y, Taylor SS. The gene product of a Trypanosoma equiperdum ortholog of the cAMP-dependent protein kinase regulatory subunit is a monomeric protein that is not capable of binding cyclic nucleotides. Biochimie. PMID 29288679 DOI: 10.1016/j.biochi.2017.12.010  1
2017 Sastri M, Darshi M, Mackey M, Ramachandra R, Ju S, Phan S, Adams S, Stein K, Douglas CR, Kim JJ, Ellisman MH, Taylor SS, Perkins GA. Sub-mitochondrial localization of genetic-tagged MIB interacting partners: Mic19, Mic60 and Sam50. Journal of Cell Science. PMID 28808085 DOI: 10.1242/jcs.201400  0.44
2017 Kim J, Ahuja LG, Chao FA, Xia Y, McClendon CL, Kornev AP, Taylor SS, Veglia G. A dynamic hydrophobic core orchestrates allostery in protein kinases. Science Advances. 3: e1600663. PMID 28435869 DOI: 10.1126/sciadv.1600663  0.72
2017 Pecora de Barros E, Malmstrom RD, Nourbakhsh K, Del Rio JC, Kornev AP, Taylor SS, Amaro RE. Electrostatic interactions as mediators in the allosteric activation of PKA RIα. Biochemistry. PMID 28221775 DOI: 10.1021/acs.biochem.6b01152  0.72
2017 Ahuja LG, Kornev AP, McClendon CL, Veglia G, Taylor SS. Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer. Proceedings of the National Academy of Sciences of the United States of America. PMID 28115705 DOI: 10.1073/pnas.1620667114  0.72
2016 Meharena HS, Fan X, Ahuja LG, Keshwani MM, McClendon CL, Chen AM, Adams JA, Taylor SS. Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases. Plos Biology. 14: e2000127. PMID 27902690 DOI: 10.1371/journal.pbio.2000127  0.56
2016 Bruystens JG, Wu J, Fortezzo A, Del Rio J, Nielsen C, Blumenthal DK, Rock R, Stefan E, Taylor SS. Structure of a PKA RIα Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation. Journal of Molecular Biology. PMID 27825928 DOI: 10.1016/j.jmb.2016.10.033  0.4
2016 Bachmann VA, Mayrhofer JE, Ilouz R, Tschaikner P, Raffeiner P, Röck R, Courcelles M, Apelt F, Lu TW, Baillie GS, Thibault P, Aanstad P, Stelzl U, Taylor SS, Stefan E. Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 27357676 DOI: 10.1073/pnas.1608061113  0.36
2016 Burgers PP, Bruystens J, Burnley RJ, Nikolaev VO, Keshwani M, Wu J, Janssen BJ, Taylor SS, Heck AJ, Scholten A. Structure of smAKAP and its regulation by PKA-mediated phosphorylation. The Febs Journal. PMID 27028580 DOI: 10.1111/febs.13726  0.32
2016 Kim J, Li G, Walters MA, Taylor SS, Veglia G. Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase A. Structure (London, England : 1993). PMID 26833386 DOI: 10.1016/j.str.2015.11.016  0.4
2016 Chávez-Vargas L, Adame-García SR, Cervantes-Villagrana RD, Castillo-Kauil A, Bruystens JG, Fukuhara S, Taylor SS, Mochizuki N, Reyes-Cruz G, Vázquez-Prado J. Protein kinase A (PKA) Type I interacts with P-Rex1, a Rac guanine nucleotide exchange factor: Effect on PKA localization and P-Rex1 signaling. The Journal of Biological Chemistry. PMID 26797121 DOI: 10.1074/jbc.M115.712216  0.4
2015 Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel AR, et al. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Reports. PMID 26748707 DOI: 10.1016/j.celrep.2015.12.028  0.4
2015 Akimoto M, McNicholl ET, Ramkissoon A, Moleschi K, Taylor SS, Melacini G. Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα. Plos Biology. 13: e1002305. PMID 26618408 DOI: 10.1371/journal.pbio.1002305  1
2015 Kornev AP, Taylor SS. Dynamics-Driven Allostery in Protein Kinases. Trends in Biochemical Sciences. 40: 628-47. PMID 26481499 DOI: 10.1016/j.tibs.2015.09.002  1
2015 Keshwani MM, Kanter JR, Ma Y, Wilderman A, Darshi M, Insel PA, Taylor SS. Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system. Proceedings of the National Academy of Sciences of the United States of America. PMID 26417071 DOI: 10.1073/pnas.1516057112  1
2015 Antal CE, Callender JA, Kornev AP, Taylor SS, Newton AC. Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII. Cell Reports. 12: 1252-60. PMID 26279568 DOI: 10.1016/j.celrep.2015.07.039  1
2015 Zhang P, Ye F, Bastidas AC, Kornev AP, Wu J, Ginsberg MH, Taylor SS. An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure (London, England : 1993). PMID 26278174 DOI: 10.1016/j.str.2015.07.007  1
2015 Wilderman A, Guo Y, Divakaruni AS, Perkins G, Zhang L, Murphy AN, Taylor SS, Insel PA. Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A. The Journal of Biological Chemistry. 290: 22274-86. PMID 26203188 DOI: 10.1074/jbc.M115.658153  1
2015 Knape MJ, Ahuja LG, Bertinetti D, Burghardt NC, Zimmermann B, Taylor SS, Herberg FW. Divalent Metal Ions Mg(2+) and Ca(2+) Have Distinct Effects on Protein Kinase A Activity and Regulation. Acs Chemical Biology. 10: 2303-15. PMID 26200257 DOI: 10.1021/acschembio.5b00271  1
2015 Zhang P, Knape MJ, Ahuja LG, Keshwani MM, King CC, Sastri M, Herberg FW, Taylor SS. Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme. Plos Biology. 13: e1002192. PMID 26158466 DOI: 10.1371/journal.pbio.1002192  1
2015 Malmstrom RD, Kornev AP, Taylor SS, Amaro RE. Allostery through the computational microscope: cAMP activation of a canonical signalling domain. Nature Communications. 6: 7588. PMID 26145448 DOI: 10.1038/ncomms8588  0.72
2015 Zhang P, Kornev AP, Wu J, Taylor SS. Discovery of Allostery in PKA Signaling. Biophysical Reviews. 7: 227-238. PMID 26097522 DOI: 10.1007/s12551-015-0170-x  0.72
2015 Schmidts M, Hou Y, Cortés CR, Mans DA, Huber C, Boldt K, Patel M, van Reeuwijk J, Plaza JM, van Beersum SE, Yap ZM, Letteboer SJ, Taylor SP, Herridge W, Johnson CA, et al. TCTEX1D2 mutations underlie Jeune asphyxiating thoracic dystrophy with impaired retrograde intraflagellar transport. Nature Communications. 6: 7074. PMID 26044572 DOI: 10.1038/ncomms8074  0.32
2015 Li GC, Srivastava AK, Kim J, Taylor SS, Veglia G. Mapping the Hydrogen Bond Networks in the Catalytic Subunit of Protein Kinase A Using H/D Fractionation Factors. Biochemistry. 54: 4042-9. PMID 26030372 DOI: 10.1021/acs.biochem.5b00387  1
2015 Wei SC, Fattet L, Tsai JH, Guo Y, Pai VH, Majeski HE, Chen AC, Sah RL, Taylor SS, Engler AJ, Yang J. Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway. Nature Cell Biology. 17: 678-88. PMID 25893917 DOI: 10.1038/ncb3157  0.4
2015 Taylor SS, Shaw AS, Kannan N, Kornev AP. Integration of signaling in the kinome: Architecture and regulation of the αC Helix. Biochimica Et Biophysica Acta. PMID 25891902 DOI: 10.1016/j.bbapap.2015.04.007  1
2015 Mohanty S, Kennedy EJ, Herberg FW, Hui R, Taylor SS, Langsley G, Kannan N. Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design. Biochimica Et Biophysica Acta. PMID 25847873 DOI: 10.1016/j.bbapap.2015.03.012  1
2015 Kim J, Masterson LR, Cembran A, Verardi R, Shi L, Gao J, Taylor SS, Veglia G. Dysfunctional conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 112: 3716-21. PMID 25775607 DOI: 10.1073/pnas.1502299112  1
2015 McSkimming DI, Dastgheib S, Talevich E, Narayanan A, Katiyar S, Taylor SS, Kochut K, Kannan N. ProKinO: a unified resource for mining the cancer kinome. Human Mutation. 36: 175-86. PMID 25382819 DOI: 10.1002/humu.22726  1
2015 Niyitegeka JM, Bastidas AC, Newman RH, Taylor SS, Ongeri EM. Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A: significance in acute and chronic kidney injury. American Journal of Physiology. Renal Physiology. 308: F56-68. PMID 25354939 DOI: 10.1152/ajprenal.00167.2014  1
2015 Hu J, Ahuja LG, Meharena HS, Kannan N, Kornev AP, Taylor SS, Shaw AS. Kinase regulation by hydrophobic spine assembly in cancer. Molecular and Cellular Biology. 35: 264-76. PMID 25348715 DOI: 10.1128/MCB.00943-14  1
2015 Sarma GN, Moody IS, Ilouz R, Phan RH, Sankaran B, Hall RA, Taylor SS. D-AKAP2:PKA RII:PDZK1 ternary complex structure: insights from the nucleation of a polyvalent scaffold. Protein Science : a Publication of the Protein Society. 24: 105-16. PMID 25348485 DOI: 10.1002/pro.2593  1
2015 Bastidas AC, Wu J, Taylor SS. Molecular features of product release for the PKA catalytic cycle. Biochemistry. 54: 2-10. PMID 25077557 DOI: 10.1021/bi500684c  1
2015 Malmstrom RD, Kornev AP, Taylor SS, Amaro RE. Allostery through the computational microscope: CAMP activation of a canonical signalling domain Nature Communications. 6. DOI: 10.1038/ncomms8588  1
2014 Srivastava AK, McDonald LR, Cembran A, Kim J, Masterson LR, McClendon CL, Taylor SS, Veglia G. Synchronous opening and closing motions are essential for cAMP-dependent protein kinase A signaling. Structure (London, England : 1993). 22: 1735-43. PMID 25458836 DOI: 10.1016/j.str.2014.09.010  1
2014 McClendon CL, Kornev AP, Gilson MK, Taylor SS. Dynamic architecture of a protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 111: E4623-31. PMID 25319261 DOI: 10.1073/pnas.1418402111  0.72
2014 Boras BW, Kornev A, Taylor SS, McCulloch AD. Using Markov state models to develop a mechanistic understanding of protein kinase A regulatory subunit RIα activation in response to cAMP binding. The Journal of Biological Chemistry. 289: 30040-51. PMID 25202018 DOI: 10.1074/jbc.M114.568907  1
2014 Blumenthal DK, Copps J, Smith-Nguyen EV, Zhang P, Heller WT, Taylor SS. The roles of the RIIβ linker and N-terminal cyclic nucleotide-binding domain in determining the unique structures of the type IIβ protein kinase A: a small angle x-ray and neutron scattering study. The Journal of Biological Chemistry. 289: 28505-12. PMID 25112875 DOI: 10.1074/jbc.M114.584177  1
2014 Gerlits O, Das A, Keshwani MM, Taylor S, Waltman MJ, Langan P, Heller WT, Kovalevsky A. Metal-free cAMP-dependent protein kinase can catalyze phosphoryl transfer. Biochemistry. 53: 3179-86. PMID 24786636 DOI: 10.1021/bi5000965  1
2014 Shaw AS, Kornev AP, Hu J, Ahuja LG, Taylor SS. Kinases and pseudokinases: lessons from RAF. Molecular and Cellular Biology. 34: 1538-46. PMID 24567368 DOI: 10.1128/MCB.00057-14  1
2014 Akimoto M, Moleschi K, Boulton S, VanSchouwen B, Selvaratnam R, Taylor SS, Melacini G. Allosteric linkers in cAMP signalling. Biochemical Society Transactions. 42: 139-44. PMID 24450641 DOI: 10.1042/BST20130257  1
2014 Bruystens JG, Wu J, Fortezzo A, Kornev AP, Blumenthal DK, Taylor SS. PKA RIα homodimer structure reveals an intermolecular interface with implications for cooperative cAMP binding and Carney complex disease. Structure (London, England : 1993). 22: 59-69. PMID 24316401 DOI: 10.1016/j.str.2013.10.012  1
2013 Meharena HS, Chang P, Keshwani MM, Oruganty K, Nene AK, Kannan N, Taylor SS, Kornev AP. Deciphering the structural basis of eukaryotic protein kinase regulation. Plos Biology. 11: e1001680. PMID 24143133 DOI: 10.1371/journal.pbio.1001680  0.72
2013 Okada H, Lai NC, Kawaraguchi Y, Liao P, Copps J, Sugano Y, Okada-Maeda S, Banerjee I, Schilling JM, Gingras AR, Asfaw EK, Suarez J, Kang SM, Perkins GA, Au CG, ... ... Taylor SS, et al. Integrins protect cardiomyocytes from ischemia/reperfusion injury. The Journal of Clinical Investigation. 123: 4294-308. PMID 24091324 DOI: 10.1172/JCI64216  1
2013 Guo Y, Darshi M, Ma Y, Perkins GA, Shen Z, Haushalter KJ, Saito R, Chen A, Lee YS, Patel HH, Briggs SP, Ellisman MH, Olefsky JM, Taylor SS. Quantitative proteomic and functional analysis of liver mitochondria from high fat diet (HFD) diabetic mice. Molecular & Cellular Proteomics : McP. 12: 3744-58. PMID 24030101 DOI: 10.1074/mcp.M113.027441  1
2013 Bastidas AC, Pierce LC, Walker RC, Johnson DA, Taylor SS. Influence of N-myristylation and ligand binding on the flexibility of the catalytic subunit of protein kinase A. Biochemistry. 52: 6368-79. PMID 24003983 DOI: 10.1021/bi400575k  1
2013 Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJ, Kornev AP, Taylor SS, Shaw AS. Allosteric activation of functionally asymmetric RAF kinase dimers. Cell. 154: 1036-46. PMID 23993095 DOI: 10.1016/j.cell.2013.07.046  1
2013 Brown SH, Cheng CY, Saldanha SA, Wu J, Cottam HB, Sankaran B, Taylor SS. Implementing fluorescence anisotropy screening and crystallographic analysis to define PKA isoform-selective activation by cAMP analogs. Acs Chemical Biology. 8: 2164-72. PMID 23978166 DOI: 10.1021/cb400247t  0.32
2013 Akimoto M, Selvaratnam R, McNicholl ET, Verma G, Taylor SS, Melacini G. Signaling through dynamic linkers as revealed by PKA. Proceedings of the National Academy of Sciences of the United States of America. 110: 14231-6. PMID 23946424 DOI: 10.1073/pnas.1312644110  1
2013 Taylor SS, Shaw A, Hu J, Meharena HS, Kornev A. Pseudokinases from a structural perspective. Biochemical Society Transactions. 41: 981-6. PMID 23863167 DOI: 10.1042/BST20130120  1
2013 Laanemets K, Brandt B, Li J, Merilo E, Wang YF, Keshwani MM, Taylor SS, Kollist H, Schroeder JI. Calcium-dependent and -independent stomatal signaling network and compensatory feedback control of stomatal opening via Ca2+ sensitivity priming. Plant Physiology. 163: 504-13. PMID 23766366 DOI: 10.1104/pp.113.220343  0.56
2013 Yu FX, Zhang Y, Park HW, Jewell JL, Chen Q, Deng Y, Pan D, Taylor SS, Lai ZC, Guan KL. Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. Genes & Development. 27: 1223-32. PMID 23752589 DOI: 10.1101/gad.219402.113  1
2013 Taylor SS, Zhang P, Steichen JM, Keshwani MM, Kornev AP. PKA: lessons learned after twenty years. Biochimica Et Biophysica Acta. 1834: 1271-8. PMID 23535202 DOI: 10.1016/j.bbapap.2013.03.007  1
2013 Bastidas AC, Deal MS, Steichen JM, Guo Y, Wu J, Taylor SS. Phosphoryl transfer by protein kinase A is captured in a crystal lattice. Journal of the American Chemical Society. 135: 4788-98. PMID 23458248 DOI: 10.1021/ja312237q  1
2013 Sastri M, Haushalter KJ, Panneerselvam M, Chang P, Fridolfsson H, Finley JC, Ng D, Schilling JM, Miyanohara A, Day ME, Hakozaki H, Petrosyan S, Koller A, King CC, Darshi M, ... ... Taylor SS, et al. A kinase interacting protein (AKIP1) is a key regulator of cardiac stress. Proceedings of the National Academy of Sciences of the United States of America. 110: E387-96. PMID 23319652 DOI: 10.1073/pnas.1221670110  1
2012 Cembran A, Masterson LR, McClendon CL, Taylor SS, Gao J, Veglia G. Conformational equilibrium of N-myristoylated cAMP-dependent protein kinase A by molecular dynamics simulations. Biochemistry. 51: 10186-96. PMID 23205665 DOI: 10.1021/bi301279f  1
2012 Burgers PP, Ma Y, Margarucci L, Mackey M, van der Heyden MA, Ellisman M, Scholten A, Taylor SS, Heck AJ. A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane. The Journal of Biological Chemistry. 287: 43789-97. PMID 23115245 DOI: 10.1074/jbc.M112.395970  1
2012 Guo Y, Wilderman A, Zhang L, Taylor SS, Insel PA. Quantitative proteomics analysis of the cAMP/protein kinase A signaling pathway. Biochemistry. 51: 9323-32. PMID 23110364 DOI: 10.1021/bi301282k  1
2012 Darshi M, Trinh KN, Murphy AN, Taylor SS. Targeting and import mechanism of coiled-coil helix coiled-coil helix domain-containing protein 3 (ChChd3) into the mitochondrial intermembrane space. The Journal of Biological Chemistry. 287: 39480-91. PMID 23019327 DOI: 10.1074/jbc.M112.387696  1
2012 Taylor SS, Ilouz R, Zhang P, Kornev AP. Assembly of allosteric macromolecular switches: lessons from PKA. Nature Reviews. Molecular Cell Biology. 13: 646-58. PMID 22992589 DOI: 10.1038/nrm3432  1
2012 Taylor SS, Keshwani MM, Steichen JM, Kornev AP. Evolution of the eukaryotic protein kinases as dynamic molecular switches. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 367: 2517-28. PMID 22889904 DOI: 10.1098/rstb.2012.0054  1
2012 Ilouz R, Bubis J, Wu J, Yim YY, Deal MS, Kornev AP, Ma Y, Blumenthal DK, Taylor SS. Localization and quaternary structure of the PKA RIβ holoenzyme. Proceedings of the National Academy of Sciences of the United States of America. 109: 12443-8. PMID 22797896 DOI: 10.1073/pnas.1209538109  1
2012 Haste NM, Talabani H, Doo A, Merckx A, Langsley G, Taylor SS. Exploring the Plasmodium falciparum cyclic-adenosine monophosphate (cAMP)-dependent protein kinase (PfPKA) as a therapeutic target. Microbes and Infection / Institut Pasteur. 14: 838-50. PMID 22626931 DOI: 10.1016/j.micinf.2012.05.004  1
2012 Bastidas AC, Deal MS, Steichen JM, Keshwani MM, Guo Y, Taylor SS. Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase. Journal of Molecular Biology. 422: 215-29. PMID 22617327 DOI: 10.1016/j.jmb.2012.05.021  1
2012 Keshwani MM, Klammt C, von Daake S, Ma Y, Kornev AP, Choe S, Insel PA, Taylor SS. Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 109: E1221-9. PMID 22493239 DOI: 10.1073/pnas.1202741109  1
2012 Steichen JM, Kuchinskas M, Keshwani MM, Yang J, Adams JA, Taylor SS. Structural basis for the regulation of protein kinase A by activation loop phosphorylation. The Journal of Biological Chemistry. 287: 14672-80. PMID 22334660 DOI: 10.1074/jbc.M111.335091  1
2012 Zhang P, Smith-Nguyen EV, Keshwani MM, Deal MS, Kornev AP, Taylor SS. Structure and allostery of the PKA RIIβ tetrameric holoenzyme. Science (New York, N.Y.). 335: 712-6. PMID 22323819 DOI: 10.1126/science.1213979  1
2012 Abrahamsen H, O'Neill AK, Kannan N, Kruse N, Taylor SS, Jennings PA, Newton AC. Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes. The Journal of Biological Chemistry. 287: 13262-78. PMID 22318721 DOI: 10.1074/jbc.M112.349753  1
2012 Yang J, Wu J, Steichen JM, Kornev AP, Deal MS, Li S, Sankaran B, Woods VL, Taylor SS. A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold. Journal of Molecular Biology. 415: 666-79. PMID 22138346 DOI: 10.1016/j.jmb.2011.11.035  1
2011 Means CK, Lygren B, Langeberg LK, Jain A, Dixon RE, Vega AL, Gold MG, Petrosyan S, Taylor SS, Murphy AN, Ha T, Santana LF, Tasken K, Scott JD. An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. Proceedings of the National Academy of Sciences of the United States of America. 108: E1227-35. PMID 22084075 DOI: 10.1073/pnas.1107182108  1
2011 Osborne BW, Wu J, McFarland CJ, Nickl CK, Sankaran B, Casteel DE, Woods VL, Kornev AP, Taylor SS, Dostmann WR. Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication. Structure (London, England : 1993). 19: 1317-27. PMID 21893290 DOI: 10.1016/j.str.2011.06.012  1
2011 Keshwani MM, von Daake S, Newton AC, Harris TK, Taylor SS. Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1). The Journal of Biological Chemistry. 286: 23552-8. PMID 21561857 DOI: 10.1074/jbc.M111.258004  0.56
2011 King CC, Sastri M, Chang P, Pennypacker J, Taylor SS. The rate of NF-κB nuclear translocation is regulated by PKA and A kinase interacting protein 1. Plos One. 6: e18713. PMID 21556136 DOI: 10.1371/journal.pone.0018713  1
2011 Day ME, Gaietta GM, Sastri M, Koller A, Mackey MR, Scott JD, Perkins GA, Ellisman MH, Taylor SS. Isoform-specific targeting of PKA to multivesicular bodies. The Journal of Cell Biology. 193: 347-63. PMID 21502359 DOI: 10.1083/jcb.201010034  1
2011 Masterson LR, Shi L, Metcalfe E, Gao J, Taylor SS, Veglia G. Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 108: 6969-74. PMID 21471451 DOI: 10.1073/pnas.1102701108  1
2011 Hu J, Yu H, Kornev AP, Zhao J, Filbert EL, Taylor SS, Shaw AS. Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF. Proceedings of the National Academy of Sciences of the United States of America. 108: 6067-72. PMID 21441104 DOI: 10.1073/pnas.1102554108  1
2011 Boettcher AJ, Wu J, Kim C, Yang J, Bruystens J, Cheung N, Pennypacker JK, Blumenthal DA, Kornev AP, Taylor SS. Realizing the allosteric potential of the tetrameric protein kinase A RIα holoenzyme. Structure (London, England : 1993). 19: 265-76. PMID 21300294 DOI: 10.1016/j.str.2010.12.005  0.72
2011 McLaughlin WA, Hou T, Taylor SS, Wang W. The identification of novel cyclic AMP-dependent protein kinase anchoring proteins using bioinformatic filters and peptide arrays. Protein Engineering, Design & Selection : Peds. 24: 333-9. PMID 21115539 DOI: 10.1093/protein/gzq106  1
2011 Badireddy S, Yunfeng G, Ritchie M, Akamine P, Wu J, Kim CW, Taylor SS, Qingsong L, Swaminathan K, Anand GS. Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: conformational selection highlights a new concept in allosteric inhibitor design. Molecular & Cellular Proteomics : McP. 10: M110.004390. PMID 21081668 DOI: 10.1074/mcp.M110.004390  1
2011 Darshi M, Mendiola VL, Mackey MR, Murphy AN, Koller A, Perkins GA, Ellisman MH, Taylor SS. ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. The Journal of Biological Chemistry. 286: 2918-32. PMID 21081504 DOI: 10.1074/jbc.M110.171975  1
2011 Taylor SS, Kornev AP. Protein kinases: evolution of dynamic regulatory proteins. Trends in Biochemical Sciences. 36: 65-77. PMID 20971646 DOI: 10.1016/j.tibs.2010.09.006  1
2010 Rinaldi J, Wu J, Yang J, Ralston CY, Sankaran B, Moreno S, Taylor SS. Structure of yeast regulatory subunit: a glimpse into the evolution of PKA signaling. Structure (London, England : 1993). 18: 1471-82. PMID 21070946 DOI: 10.1016/j.str.2010.08.013  1
2010 Masterson LR, Cheng C, Yu T, Tonelli M, Kornev A, Taylor SS, Veglia G. Dynamics connect substrate recognition to catalysis in protein kinase A. Nature Chemical Biology. 6: 821-8. PMID 20890288 DOI: 10.1038/nchembio.452  1
2010 Patel HH, Hamuro LL, Chun BJ, Kawaraguchi Y, Quick A, Rebolledo B, Pennypacker J, Thurston J, Rodriguez-Pinto N, Self C, Olson G, Insel PA, Giles WR, Taylor SS, Roth DM. Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function. The Journal of Biological Chemistry. 285: 27632-40. PMID 20581396 DOI: 10.1074/jbc.M110.146589  1
2010 Sjoberg TJ, Kornev AP, Taylor SS. Dissecting the cAMP-inducible allosteric switch in protein kinase A RIalpha. Protein Science : a Publication of the Protein Society. 19: 1213-21. PMID 20512974 DOI: 10.1002/pro.400  1
2010 Gleick PH, Adams RM, Amasino RM, Anders E, Anderson DJ, Anderson WW, Anselin LE, Arroyo MK, Asfaw B, Ayala FJ, Bax A, Bebbington AJ, Bell G, Bennett MV, Bennetzen JL, ... ... Taylor SS, et al. Climate change and the integrity of science. Science (New York, N.Y.). 328: 689-90. PMID 20448167 DOI: 10.1126/science.328.5979.689  0.52
2010 Taylor SS, Kornev AP. Yet another "active" pseudokinase, Erb3. Proceedings of the National Academy of Sciences of the United States of America. 107: 8047-8. PMID 20421461 DOI: 10.1073/pnas.1003436107  1
2010 McNicholl ET, Das R, SilDas S, Taylor SS, Melacini G. Communication between tandem cAMP binding domains in the regulatory subunit of protein kinase A-Ialpha as revealed by domain-silencing mutations. The Journal of Biological Chemistry. 285: 15523-37. PMID 20202931 DOI: 10.1074/jbc.M110.105783  1
2010 Anand GS, Krishnamurthy S, Bishnoi T, Kornev A, Taylor SS, Johnson DA. Cyclic AMP- and (Rp)-cAMPS-induced conformational changes in a complex of the catalytic and regulatory (RI{alpha}) subunits of cyclic AMP-dependent protein kinase. Molecular & Cellular Proteomics : McP. 9: 2225-37. PMID 20167947 DOI: 10.1074/mcp.M900388-MCP200  1
2010 Sarma GN, Kinderman FS, Kim C, von Daake S, Chen L, Wang BC, Taylor SS. Structure of D-AKAP2:PKA RI complex: insights into AKAP specificity and selectivity. Structure (London, England : 1993). 18: 155-66. PMID 20159461 DOI: 10.1016/j.str.2009.12.012  1
2010 Steichen JM, Iyer GH, Li S, Saldanha SA, Deal MS, Woods VL, Taylor SS. Global consequences of activation loop phosphorylation on protein kinase A. The Journal of Biological Chemistry. 285: 3825-32. PMID 19965870 DOI: 10.1074/jbc.M109.061820  1
2010 Kornev AP, Taylor SS. Defining the conserved internal architecture of a protein kinase. Biochimica Et Biophysica Acta. 1804: 440-4. PMID 19879387 DOI: 10.1016/j.bbapap.2009.10.017  1
2009 Khavrutskii IV, Grant B, Taylor SS, McCammon JA. A transition path ensemble study reveals a linchpin role for Mg(2+) during rate-limiting ADP release from protein kinase A. Biochemistry. 48: 11532-45. PMID 19886670 DOI: 10.1021/bi901475g  0.68
2009 Cheng CY, Yang J, Taylor SS, Blumenthal DK. Sensing domain dynamics in protein kinase A-I{alpha} complexes by solution X-ray scattering. The Journal of Biological Chemistry. 284: 35916-25. PMID 19837668 DOI: 10.1074/jbc.M109.059493  0.4
2009 Eggers CT, Schafer JC, Goldenring JR, Taylor SS. D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling. The Journal of Biological Chemistry. 284: 32869-80. PMID 19797056 DOI: 10.1074/jbc.M109.022582  1
2009 Brown SH, Wu J, Kim C, Alberto K, Taylor SS. Novel isoform-specific interfaces revealed by PKA RIIbeta holoenzyme structures. Journal of Molecular Biology. 393: 1070-82. PMID 19748511 DOI: 10.1016/j.jmb.2009.09.014  0.44
2009 Thompson EE, Kornev AP, Kannan N, Kim C, Ten Eyck LF, Taylor SS. Comparative surface geometry of the protein kinase family. Protein Science : a Publication of the Protein Society. 18: 2016-26. PMID 19610074 DOI: 10.1002/pro.209  0.72
2009 Romano RA, Kannan N, Kornev AP, Allison CJ, Taylor SS. A chimeric mechanism for polyvalent trans-phosphorylation of PKA by PDK1. Protein Science : a Publication of the Protein Society. 18: 1486-97. PMID 19530248 DOI: 10.1002/pro.146  0.72
2009 Kennedy EJ, Yang J, Pillus L, Taylor SS, Ghosh G. Identifying critical non-catalytic residues that modulate protein kinase A activity. Plos One. 4: e4746. PMID 19270744 DOI: 10.1371/journal.pone.0004746  1
2009 Kornev AP, Taylor SS. Pseudokinases: functional insights gleaned from structure. Structure (London, England : 1993). 17: 5-7. PMID 19141276 DOI: 10.1016/j.str.2008.12.005  1
2009 Yang J, Kennedy EJ, Wu J, Deal MS, Pennypacker J, Ghosh G, Taylor SS. Contribution of non-catalytic core residues to activity and regulation in protein kinase A. The Journal of Biological Chemistry. 284: 6241-8. PMID 19122195 DOI: 10.1074/jbc.M805862200  1
2009 Gould CM, Kannan N, Taylor SS, Newton AC. The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. The Journal of Biological Chemistry. 284: 4921-35. PMID 19091746 DOI: 10.1074/jbc.M808436200  1
2008 Kornev AP, Taylor SS, Ten Eyck LF. A helix scaffold for the assembly of active protein kinases. Proceedings of the National Academy of Sciences of the United States of America. 105: 14377-82. PMID 18787129 DOI: 10.1073/pnas.0807988105  0.72
2008 Torkamani A, Kannan N, Taylor SS, Schork NJ. Congenital disease SNPs target lineage specific structural elements in protein kinases. Proceedings of the National Academy of Sciences of the United States of America. 105: 9011-6. PMID 18579784 DOI: 10.1073/pnas.0802403105  1
2008 Kannan N, Taylor SS. Rethinking pseudokinases. Cell. 133: 204-5. PMID 18423189 DOI: 10.1016/j.cell.2008.04.005  1
2008 Kornev AP, Taylor SS, Ten Eyck LF. A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains. Plos Computational Biology. 4: e1000056. PMID 18404204 DOI: 10.1371/journal.pcbi.1000056  0.72
2008 Ma Y, Taylor SS. A molecular switch for targeting between endoplasmic reticulum (ER) and mitochondria: conversion of a mitochondria-targeting element into an ER-targeting signal in DAKAP1. The Journal of Biological Chemistry. 283: 11743-51. PMID 18287098 DOI: 10.1074/jbc.M710494200  1
2008 Masterson LR, Mascioni A, Traaseth NJ, Taylor SS, Veglia G. Allosteric cooperativity in protein kinase A. Proceedings of the National Academy of Sciences of the United States of America. 105: 506-11. PMID 18178622 DOI: 10.1073/pnas.0709214104  1
2008 Ten Eyck LF, Taylor SS, Kornev AP. Conserved spatial patterns across the protein kinase family. Biochimica Et Biophysica Acta. 1784: 238-43. PMID 18067871 DOI: 10.1016/j.bbapap.2007.11.002  0.72
2008 Taylor SS, Kim C, Cheng CY, Brown SH, Wu J, Kannan N. Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design. Biochimica Et Biophysica Acta. 1784: 16-26. PMID 17996741 DOI: 10.1016/j.bbapap.2007.10.002  0.44
2008 Kannan N, Neuwald AF, Taylor SS. Analogous regulatory sites within the alphaC-beta4 loop regions of ZAP-70 tyrosine kinase and AGC kinases. Biochimica Et Biophysica Acta. 1784: 27-32. PMID 17977811 DOI: 10.1016/j.bbapap.2007.09.007  1
2007 Kannan N, Wu J, Anand GS, Yooseph S, Neuwald AF, Venter JC, Taylor SS. Evolution of allostery in the cyclic nucleotide binding module. Genome Biology. 8: R264. PMID 18076763 DOI: 10.1186/gb-2007-8-12-r264  1
2007 Valiev M, Yang J, Adams JA, Taylor SS, Weare JH. Phosphorylation reaction in cAPK protein kinase-free energy quantum mechanical/molecular mechanics simulations. The Journal of Physical Chemistry. B. 111: 13455-64. PMID 17983217 DOI: 10.1021/jp074853q  1
2007 Anand GS, Hotchko M, Brown SH, Ten Eyck LF, Komives EA, Taylor SS. R-subunit isoform specificity in protein kinase A: distinct features of protein interfaces in PKA types I and II by amide H/2H exchange mass spectrometry. Journal of Molecular Biology. 374: 487-99. PMID 17942118 DOI: 10.1016/j.jmb.2007.09.035  1
2007 Wu J, Brown SH, von Daake S, Taylor SS. PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity. Science (New York, N.Y.). 318: 274-9. PMID 17932298 DOI: 10.1126/science.1146447  0.32
2007 Alto NM, Weflen AW, Rardin MJ, Yarar D, Lazar CS, Tonikian R, Koller A, Taylor SS, Boone C, Sidhu SS, Schmid SL, Hecht GA, Dixon JE. The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. The Journal of Cell Biology. 178: 1265-78. PMID 17893247 DOI: 10.1083/jcb.200705021  1
2007 Kim C, Cheng CY, Saldanha SA, Taylor SS. PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. Cell. 130: 1032-43. PMID 17889648 DOI: 10.1016/j.cell.2007.07.018  0.44
2007 Martin BR, Deerinck TJ, Ellisman MH, Taylor SS, Tsien RY. Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells. Chemistry & Biology. 14: 1031-42. PMID 17884635 DOI: 10.1016/j.chembiol.2007.07.017  1
2007 Anand G, Taylor SS, Johnson DA. Cyclic-AMP and pseudosubstrate effects on type-I A-kinase regulatory and catalytic subunit binding kinetics. Biochemistry. 46: 9283-91. PMID 17658893 DOI: 10.1021/bi700421h  1
2007 Humphries KM, Pennypacker JK, Taylor SS. Redox regulation of cAMP-dependent protein kinase signaling: kinase versus phosphatase inactivation. The Journal of Biological Chemistry. 282: 22072-9. PMID 17548350 DOI: 10.1074/jbc.M702582200  1
2007 Lim CJ, Han J, Yousefi N, Ma Y, Amieux PS, McKnight GS, Taylor SS, Ginsberg MH. Alpha4 integrins are type I cAMP-dependent protein kinase-anchoring proteins. Nature Cell Biology. 9: 415-21. PMID 17369818 DOI: 10.1038/ncb1561  1
2007 Kannan N, Taylor SS, Zhai Y, Venter JC, Manning G. Structural and functional diversity of the microbial kinome. Plos Biology. 5: e17. PMID 17355172 DOI: 10.1371/journal.pbio.0050017  1
2007 Yooseph S, Sutton G, Rusch DB, Halpern AL, Williamson SJ, Remington K, Eisen JA, Heidelberg KB, Manning G, Li W, Jaroszewski L, Cieplak P, Miller CS, Li H, Mashiyama ST, ... ... Taylor SS, et al. The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. Plos Biology. 5: e16. PMID 17355171 DOI: 10.1371/journal.pbio.0050016  1
2007 Schauble S, King CC, Darshi M, Koller A, Shah K, Taylor SS. Identification of ChChd3 as a novel substrate of the cAMP-dependent protein kinase (PKA) using an analog-sensitive catalytic subunit. The Journal of Biological Chemistry. 282: 14952-9. PMID 17242405 DOI: 10.1074/jbc.M609221200  1
2007 Kannan N, Haste N, Taylor SS, Neuwald AF. The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module. Proceedings of the National Academy of Sciences of the United States of America. 104: 1272-7. PMID 17227859 DOI: 10.1073/pnas.0610251104  0.32
2007 Das R, Esposito V, Abu-Abed M, Anand GS, Taylor SS, Melacini G. cAMP activation of PKA defines an ancient signaling mechanism Proceedings of the National Academy of Sciences of the United States of America. 104: 93-98. PMID 17182741 DOI: 10.1073/pnas.0609033103  1
2006 Kornev AP, Haste NM, Taylor SS, Eyck LF. Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism. Proceedings of the National Academy of Sciences of the United States of America. 103: 17783-8. PMID 17095602 DOI: 10.1073/pnas.0607656103  1
2006 Kinderman FS, Kim C, von Daake S, Ma Y, Pham BQ, Spraggon G, Xuong NH, Jennings PA, Taylor SS. A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Molecular Cell. 24: 397-408. PMID 17081990 DOI: 10.1016/j.molcel.2006.09.015  1
2006 Cranston AN, Carniti C, Oakhill K, Radzio-Andzelm E, Stone EA, McCallion AS, Hodgson S, Clarke S, Mondellini P, Leyland J, Pierotti MA, Whittaker J, Taylor SS, Bongarzone I, Ponder BA. RET is constitutively activated by novel tandem mutations that alter the active site resulting in multiple endocrine neoplasia type 2B. Cancer Research. 66: 10179-87. PMID 17047083 DOI: 10.1158/0008-5472.CAN-06-0884  1
2006 Esposito V, Sjoberg T, Das R, Brown S, Taylor SS, Melacini G. NMR assignment of the cAMP-binding domain A of the PKA regulatory subunit [62] Journal of Biomolecular Nmr. 36: 64. PMID 17016670 DOI: 10.1007/s10858-006-9050-9  1
2006 Kim C, Vigil D, Anand G, Taylor SS. Structure and dynamics of PKA signaling proteins. European Journal of Cell Biology. 85: 651-4. PMID 16647784 DOI: 10.1016/j.ejcb.2006.02.004  1
2006 Vigil D, Blumenthal DK, Taylor SS, Trewhella J. Solution scattering reveals large differences in the global structures of type II protein kinase A isoforms. Journal of Molecular Biology. 357: 880-9. PMID 16460759 DOI: 10.1016/j.jmb.2006.01.006  1
2006 Niedner RH, Buzko OV, Haste NM, Taylor A, Gribskov M, Taylor SS. Protein kinase resource: an integrated environment for phosphorylation research. Proteins. 63: 78-86. PMID 16435372 DOI: 10.1002/prot.20825  1
2006 Gullingsrud J, Kim C, Taylor SS, McCammon JA. Dynamic binding of PKA regulatory subunit RIα Structure. 14: 141-149. PMID 16407073 DOI: 10.1016/j.str.2005.09.019  1
2006 Vigil D, Lin JH, Sotriffer CA, Pennypacker JK, McCammon JA, Taylor SS. A simple electrostatic switch important in the activation of type I protein kinase A by cyclic AMP. Protein Science : a Publication of the Protein Society. 15: 113-21. PMID 16322564 DOI: 10.1110/ps.051723606  0.68
2006 Taylor SS, Ghosh G. Protein kinases: Catalysis and regulation Current Opinion in Structural Biology. 16: 665-667. DOI: 10.1016/j.sbi.2006.11.001  1
2005 Burns-Hamuro LL, Hamuro Y, Kim JS, Sigala P, Fayos R, Stranz DD, Jennings PA, Taylor SS, Woods VL. Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange. Protein Science : a Publication of the Protein Society. 14: 2982-92. PMID 16260760 DOI: 10.1110/ps.051687305  1
2005 Wu J, Yang J, Kannan N, Madhusudan, Xuong NH, Ten Eyck LF, Taylor SS. Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix. Protein Science : a Publication of the Protein Society. 14: 2871-9. PMID 16253959 DOI: 10.1110/ps.051715205  0.6
2005 Taylor SS, Kim C, Vigil D, Haste NM, Yang J, Wu J, Anand GS. Dynamics of signaling by PKA. Biochimica Et Biophysica Acta. 1754: 25-37. PMID 16214430 DOI: 10.1016/j.bbapap.2005.08.024  1
2005 Taylor SS, Haste NM, Ghosh G. PKR and eIF2alpha: integration of kinase dimerization, activation, and substrate docking. Cell. 122: 823-5. PMID 16179248 DOI: 10.1016/j.cell.2005.09.007  1
2005 Zhang J, Hupfeld CJ, Taylor SS, Olefsky JM, Tsien RY. Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature. 437: 569-73. PMID 16177793 DOI: 10.1038/nature04140  1
2005 Vigil D, Blumenthal DK, Taylor SS, Trewhella J. The conformationally dynamic C helix of the RIalpha subunit of protein kinase A mediates isoform-specific domain reorganization upon C subunit binding. The Journal of Biological Chemistry. 280: 35521-7. PMID 16109722 DOI: 10.1074/jbc.M506769200  1
2005 Iyer GH, Garrod S, Woods VL, Taylor SS. Catalytic independent functions of a protein kinase as revealed by a kinase-dead mutant: study of the Lys72His mutant of cAMP-dependent kinase. Journal of Molecular Biology. 351: 1110-22. PMID 16054648 DOI: 10.1016/j.jmb.2005.06.011  1
2005 Kim C, Xuong NH, Taylor SS. Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA. Science (New York, N.Y.). 307: 690-6. PMID 15692043 DOI: 10.1126/science.1104607  1
2005 Sastri M, Barraclough DM, Carmichael PT, Taylor SS. A-kinase-interacting protein localizes protein kinase A in the nucleus. Proceedings of the National Academy of Sciences of the United States of America. 102: 349-54. PMID 15630084 DOI: 10.1073/pnas.0408608102  1
2005 Berman HM, Ten Eyck LF, Goodsell DS, Haste NM, Kornev A, Taylor SS. The cAMP binding domain: An ancient signaling module Proceedings of the National Academy of Sciences of the United States of America. 102: 45-50. PMID 15618393 DOI: 10.1073/pnas.0408579102  1
2005 Humphries KM, Deal MS, Taylor SS. Enhanced dephosphorylation of cAMP-dependent protein kinase by oxidation and thiol modification. The Journal of Biological Chemistry. 280: 2750-8. PMID 15533936 DOI: 10.1074/jbc.M410242200  1
2004 Wu J, Brown S, Xuong NH, Taylor SS. RIalpha subunit of PKA: a cAMP-free structure reveals a hydrophobic capping mechanism for docking cAMP into site B. Structure (London, England : 1993). 12: 1057-65. PMID 15274925 DOI: 10.1016/j.str.2004.03.022  1
2004 Hamuro Y, Anand GS, Kim JS, Juliano C, Stranz DD, Taylor SS, Woods VL. Mapping intersubunit interactions of the regulatory subunit (RIalpha) in the type I holoenzyme of protein kinase A by amide hydrogen/deuterium exchange mass spectrometry (DXMS). Journal of Molecular Biology. 340: 1185-96. PMID 15236976 DOI: 10.1016/j.jmb.2004.05.042  1
2004 Wu J, Jones JM, Nguyen-Huu X, Ten Eyck LF, Taylor SS. Crystal structures of RIalpha subunit of cyclic adenosine 5'-monophosphate (cAMP)-dependent protein kinase complexed with (Rp)-adenosine 3',5'-cyclic monophosphothioate and (Sp)-adenosine 3',5'-cyclic monophosphothioate, the phosphothioate analogues of cAMP. Biochemistry. 43: 6620-9. PMID 15157095 DOI: 10.1021/bi0302503  1
2004 Vigil D, Blumenthal DK, Brown S, Taylor SS, Trewhella J. Differential effects of substrate on type I and type II PKA holoenzyme dissociation. Biochemistry. 43: 5629-36. PMID 15134437 DOI: 10.1021/bi0499157  1
2004 Vigil D, Blumenthal DK, Heller WT, Brown S, Canaves JM, Taylor SS, Trewhella J. Conformational differences among solution structures of the type Ialpha, IIalpha and IIbeta protein kinase A regulatory subunit homodimers: role of the linker regions. Journal of Molecular Biology. 337: 1183-94. PMID 15046986 DOI: 10.1016/j.jmb.2004.02.028  1
2004 Taylor SS, Yang J, Wu J, Haste NM, Radzio-Andzelm E, Anand G. PKA: a portrait of protein kinase dynamics. Biochimica Et Biophysica Acta. 1697: 259-69. PMID 15023366 DOI: 10.1016/j.bbapap.2003.11.029  1
2004 Heller WT, Vigil D, Brown S, Blumenthal DK, Taylor SS, Trewhella J. C subunits binding to the protein kinase A RI alpha dimer induce a large conformational change. The Journal of Biological Chemistry. 279: 19084-90. PMID 14985329 DOI: 10.1074/jbc.M313405200  1
2004 Yang J, Ten Eyck LF, Xuong NH, Taylor SS. Crystal structure of a cAMP-dependent protein kinase mutant at 1.26A: new insights into the catalytic mechanism. Journal of Molecular Biology. 336: 473-87. PMID 14757059 DOI: 10.1016/j.jmb.2003.11.044  1
2004 Akamine P, Madhusudan, Brunton LL, Ou HD, Canaves JM, Xuong NH, Taylor SS. Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit. Biochemistry. 43: 85-96. PMID 14705934 DOI: 10.1021/bi035042p  1
2004 Zawadzki KM, Taylor SS. cAMP-dependent protein kinase regulatory subunit type IIbeta: active site mutations define an isoform-specific network for allosteric signaling by cAMP. The Journal of Biological Chemistry. 279: 7029-36. PMID 14625280 DOI: 10.1074/jbc.M310804200  1
2003 Anand GS, Law D, Mandell JG, Snead AN, Tsigelny I, Taylor SS, Ten Eyck LF, Komives EA. Identification of the protein kinase A regulatory RIalpha-catalytic subunit interface by amide H/2H exchange and protein docking. Proceedings of the National Academy of Sciences of the United States of America. 100: 13264-9. PMID 14583592 DOI: 10.1073/pnas.2232255100  1
2003 Zawadzki KM, Hamuro Y, Kim JS, Garrod S, Stranz DD, Taylor SS, Woods VL. Dissecting interdomain communication within cAPK regulatory subunit type IIβ using enhanced amide hydrogen/deuterium exchange mass spectrometry (DXMS) Protein Science. 12: 1980-1990. PMID 12930997 DOI: 10.1110/ps.03166903  1
2003 Banky P, Roy M, Newlon MG, Morikis D, Haste NM, Taylor SS, Jennings PA. Related protein-protein interaction modules present drastically different surface topographies despite a conserved helical platform. Journal of Molecular Biology. 330: 1117-29. PMID 12860132 DOI: 10.1016/S0022-2836(03)00552-7  1
2003 Zawadzki KM, Pan CP, Barkley MD, Johnson D, Taylor SS. Endogenous tryptophan residues of cAPK regulatory subunit type IIbeta reveal local variations in environments and dynamics. Proteins. 51: 552-61. PMID 12784214 DOI: 10.1002/prot.10326  1
2003 Burns LL, Canaves JM, Pennypacker JK, Blumenthal DK, Taylor SS. Isoform specific differences in binding of a dual-specificity A-kinase anchoring protein to type I and type II regulatory subunits of PKA. Biochemistry. 42: 5754-63. PMID 12741833 DOI: 10.1021/bi0265729  0.6
2003 Hamuro Y, Zawadzki KM, Kim JS, Stranz DD, Taylor SS, Woods VL. Dynamics of cAPK type IIbeta activation revealed by enhanced amide H/2H exchange mass spectrometry (DXMS). Journal of Molecular Biology. 327: 1065-76. PMID 12662931 DOI: 10.1016/S0022-2836(03)00234-1  1
2003 Kammerer S, Burns-Hamuro LL, Ma Y, Hamon SC, Canaves JM, Shi MM, Nelson MR, Sing CF, Cantor CR, Taylor SS, Braun A. Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. Proceedings of the National Academy of Sciences of the United States of America. 100: 4066-71. PMID 12646697 DOI: 10.1073/pnas.2628028100  1
2003 Burns-Hamuro LL, Ma Y, Kammerer S, Reineke U, Self C, Cook C, Olson GL, Cantor CR, Braun A, Taylor SS. Designing isoform-specific peptide disruptors of protein kinase A localization. Proceedings of the National Academy of Sciences of the United States of America. 100: 4072-7. PMID 12646696 DOI: 10.1073/pnas.2628038100  1
2003 Akamine P, Madhusudan, Wu J, Xuong NH, Ten Eyck LF, Taylor SS. Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure. Journal of Molecular Biology. 327: 159-71. PMID 12614615 DOI: 10.1016/S0022-2836(02)01446-8  1
2003 Moore MJ, Adams JA, Taylor SS. Structural basis for peptide binding in protein kinase A. Role of glutamic acid 203 and tyrosine 204 in the peptide-positioning loop. The Journal of Biological Chemistry. 278: 10613-8. PMID 12499371 DOI: 10.1074/jbc.M210807200  1
2002 Taylor SS, Kim CW, Cheng CY, Kannan N, Sastri M, Eggers CW, Wu J. Fifty Years Since the Discovery of PKA. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 4123. PMID 29430987 DOI: 10.1096/fasebj.22.1_supplement.412.3  0.44
2002 Anand GS, Hughes CA, Jones JM, Taylor SS, Komives EA. Amide H/2H exchange reveals communication between the cAMP and catalytic subunit-binding sites in the R(I)alpha subunit of protein kinase A. Journal of Molecular Biology. 323: 377-86. PMID 12381327 DOI: 10.1016/S0022-2836(02)00919-1  1
2002 Kuhn P, Lesley SA, Mathews II, Canaves JM, Brinen LS, Dai X, Deacon AM, Elsliger MA, Eshaghi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, Guda C, Hodgson KO, ... ... Taylor SS, et al. Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 A resolution. Proteins. 49: 142-5. PMID 12211025 DOI: 10.1002/prot.10202  1
2002 Lesley SA, Kuhn P, Godzik A, Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, ... ... Taylor SS, et al. Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proceedings of the National Academy of Sciences of the United States of America. 99: 11664-9. PMID 12193646 DOI: 10.1073/pnas.142413399  1
2002 Humphries KM, Juliano C, Taylor SS. Regulation of cAMP-dependent protein kinase activity by glutathionylation. The Journal of Biological Chemistry. 277: 43505-11. PMID 12189155 DOI: 10.1074/jbc.M207088200  1
2002 Madhusudan, Akamine P, Xuong NH, Taylor SS. Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase. Nature Structural Biology. 9: 273-7. PMID 11896404 DOI: 10.1038/nsb780  1
2002 Li F, Gangal M, Juliano C, Gorfain E, Taylor SS, Johnson DA. Evidence for an internal entropy contribution to phosphoryl transfer: A study of domain closure, backbone flexibility, and the catalytic cycle of cAMP-dependent protein kinase Journal of Molecular Biology. 315: 459-469. PMID 11786025 DOI: 10.1006/jmbi.2001.5256  1
2002 Canaves JM, Taylor SS. Classification and phylogenetic analysis of the cAMP-dependent protein kinase regulatory subunit family Journal of Molecular Evolution. 54: 17-29. PMID 11734894 DOI: 10.1007/s00239-001-0013-1  1
2001 Zhang J, Ma Y, Taylor SS, Tsien RY. Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering. Proceedings of the National Academy of Sciences of the United States of America. 98: 14997-5002. PMID 11752448 DOI: 10.1073/pnas.211566798  1
2001 Perkins GA, Wang L, Huang LJ, Humphries K, Yao VJ, Martone M, Deerinck TJ, Barraclough DM, Violin JD, Smith D, Newton A, Scott JD, Taylor SS, Ellisman MH. PKA, PKC, and AKAP localization in and around the neuromuscular junction. Bmc Neuroscience. 2: 17. PMID 11716788  0.44
2001 Diller TC, Madhusudan, Xuong NH, Taylor SS. Molecular basis for regulatory subunit diversity in cAMP-dependent protein kinase: crystal structure of the type II beta regulatory subunit. Structure (London, England : 1993). 9: 73-82. PMID 11342137 DOI: 10.1016/S0969-2126(00)00556-6  1
2001 Cheng X, Phelps C, Taylor SS. Differential Binding of cAMP-dependent Protein Kinase Regulatory Subunit Isoforms Iα and IIβ to the Catalytic Subunit Journal of Biological Chemistry. 276: 4102-4108. PMID 11110787 DOI: 10.1074/jbc.M006447200  1
2000 Diller TC, Xuong NH, Taylor SS. Type II beta regulatory subunit of cAMP-dependent protein kinase: purification strategies to optimize crystallization. Protein Expression and Purification. 20: 357-64. PMID 11087674 DOI: 10.1006/prep.2000.1312  1
2000 Banky P, Newlon MG, Roy M, Garrod S, Taylor SS, Jennings PA. Isoform-specific differences between the type Iα and IIα cyclic AMP-dependent protein kinase anchoring domains revealed by solution NMR Journal of Biological Chemistry. 275: 35146-35152. PMID 10899163 DOI: 10.1074/jbc.M003961200  1
2000 Aimes RT, Hemmer W, Taylor SS. Serine-53 at the tip of the glycine-rich loop of cAMP-dependent protein kinase: Role in catalysis, P-site specificity, and interaction with inhibitors Biochemistry. 39: 8325-8332. PMID 10889042 DOI: 10.1021/bi992800w  1
2000 Cheesman EJ, Sharp RJ, Zlot CH, Liu CY, Taylor S, Marcovina SM, Young SG, McCormick SP. An analysis of the interaction between mouse apolipoprotein B100 and apolipoprotein(a). The Journal of Biological Chemistry. 275: 28195-200. PMID 10837476 DOI: 10.1074/jbc.M002772200  1
2000 Leon DA, Canaves JM, Taylor SS. Probing the multidomain structure of the type I regulatory subunit of cAMP-dependent protein kinase using mutational analysis: Role and environment of endogenous tryptophans Biochemistry. 39: 5662-5671. PMID 10801316 DOI: 10.1021/bi992819z  1
2000 Zaccolo M, De Giorgi F, Cho CY, Feng L, Knapp T, Negulescu PA, Taylor SS, Tsien RY, Pozzan T. A genetically encoded, fluorescent indicator for cyclic AMP in living cells. Nature Cell Biology. 2: 25-9. PMID 10620803 DOI: 10.1038/71345  1
1999 Tsigelny I, Greenberg JP, Cox S, Nichols WL, Taylor SS, Ten Eyck LF. 600 ps molecular dynamics reveals stable substructures and flexible hinge points in cAMP dependent protein kinase. Biopolymers. 50: 513-24. PMID 10479734 DOI: 10.1002/(SICI)1097-0282(19991015)50:5<513::AID-BIP5>3.0.CO;2-I  1
1999 Setyawan J, Koide K, Diller TC, Bunnage ME, Taylor SS, Nicolaou KC, Brunton LL. Inhibition of protein kinases by balanol: specificity within the serine/threonine protein kinase subfamily. Molecular Pharmacology. 56: 370-6. PMID 10419556 DOI: 10.1124/mol.56.2.370  1
1999 Herberg FW, Doyle ML, Cox S, Taylor SS. Dissection of the nucleotide and metal-phosphate binding sites in cAMP-dependent protein kinase. Biochemistry. 38: 6352-60. PMID 10320366 DOI: 10.1021/bi982672w  1
1999 Narayana N, Diller TC, Koide K, Bunnage ME, Nicolaou KC, Brunton LL, Xuong NH, Ten Eyck LF, Taylor SS. Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase. Biochemistry. 38: 2367-76. PMID 10029530 DOI: 10.1021/bi9820659  1
1998 Narayana N, Akamine P, Xuong NH, Taylor SS. Crystallization and preliminary X-ray analysis of the unliganded recombinant catalytic subunit of cAMP-dependent protein kinase Acta Crystallographica Section D: Biological Crystallography. 54: 1401-1404. PMID 10089519 DOI: 10.1107/S0907444998005770  1
1998 Banky P, Huang LJ, Taylor SS. Dimerization/docking domain of the type Ialpha regulatory subunit of cAMP-dependent protein kinase. Requirements for dimerization and docking are distinct but overlapping. The Journal of Biological Chemistry. 273: 35048-55. PMID 9857038 DOI: 10.1074/jbc.273.52.35048  1
1998 Struppe J, Komives EA, Taylor SS, Vold RR. 2H NMR studies of a myristoylated peptide in neutral and acidic phospholipid bicelles. Biochemistry. 37: 15523-7. PMID 9799515 DOI: 10.1021/bi981326b  1
1998 Cheng X, Shaltiel S, Taylor SS. Mapping substrate-induced conformational changes in cAMP-dependent protein kinase by protein footprinting Biochemistry. 37: 14005-14013. PMID 9760235 DOI: 10.1021/bi981057p  1
1998 Huang LJS, Taylor SS. Dissecting cAMP binding domain A in the R1α subunit of cAMP-dependent protein kinase: Distinct subsites for recognition of cAMP and the catalytic subunit Journal of Biological Chemistry. 273: 26739-26746. PMID 9756917 DOI: 10.1074/jbc.273.41.26739  1
1998 Gangal M, Cox S, Lew J, Clifford T, Garrod SM, Aschbaher M, Taylor SS, Johnson DA. Backbone flexibility of five sites on the catalytic subunit of cAMP- dependent protein kinase in the open and closed conformations Biochemistry. 37: 13728-13735. PMID 9753461 DOI: 10.1021/bi980560z  1
1998 de Lecea L, Criado JR, Rivera S, Wen W, Soriano E, Henriksen SJ, Taylor SS, Gall CM, Sutcliffe JG. Endogenous protein kinase A inhibitor (PKIalpha) modulates synaptic activity. Journal of Neuroscience Research. 53: 269-78. PMID 9698155 DOI: 10.1002/(SICI)1097-4547(19980801)53:3<269::AID-JNR1>3.0.CO;2-8  1
1998 Grant BD, Hemmer W, Tsigelny I, Adams JA, Taylor SS. Kinetic analyses of mutations in the glycine-rich loop of cAMP-dependent protein kinase. Biochemistry. 37: 7708-15. PMID 9601030 DOI: 10.1021/bi972987w  1
1998 Borén J, Lee I, Zhu W, Arnold K, Taylor S, Innerarity TL. Identification of the low density lipoprotein receptor-binding site in apolipoprotein B100 and the modulation of its binding activity by the carboxyl terminus in familial defective Apo-B100 Journal of Clinical Investigation. 101: 1084-1093. PMID 9486979 DOI: 10.1172/JCI1847  1
1998 Shaltiel S, Cox S, Taylor SS. Conserved water molecules contribute to the extensive network of interactions at the active site of protein kinase A Proceedings of the National Academy of Sciences of the United States of America. 95: 484-491. PMID 9435218 DOI: 10.1073/pnas.95.2.484  1
1997 Taylor SS, Radzio-Andzelm E. Protein kinase inhibition: Natural and synthetic variations on a theme Current Opinion in Chemical Biology. 1: 219-226. PMID 9667861 DOI: 10.1016/S1367-5931(97)80013-0  1
1997 Yonemoto W, McGlone ML, Grant B, Taylor SS. Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli. Protein Engineering. 10: 915-25. PMID 9415441 DOI: 10.1093/PROTEIN/10.8.915  0.68
1997 Gibson RM, Taylor SS. Dissecting the cooperative reassociation of the regulatory and catalytic subunits of cAMP-dependent protein kinase. Role of Trp-196 in the catalytic subunit Journal of Biological Chemistry. 272: 31998-32005. PMID 9405392 DOI: 10.1074/jbc.272.51.31998  1
1997 Allan CM, Taylor S, Taylor JM. Two hepatic enhancers, HCR.1 and HCR.2, coordinate the liver expression of the entire human apolipoprotein E/C-I/C-IV/C-II gene cluster. The Journal of Biological Chemistry. 272: 29113-9. PMID 9360987 DOI: 10.1074/jbc.272.46.29113  1
1997 León DA, Herberg FW, Banky P, Taylor SS. A stable alpha-helical domain at the N terminus of the RIalpha subunits of cAMP-dependent protein kinase is a novel dimerization/docking motif. The Journal of Biological Chemistry. 272: 28431-7. PMID 9353302 DOI: 10.1074/jbc.272.45.28431  1
1997 Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS. D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain. Proceedings of the National Academy of Sciences of the United States of America. 94: 11184-9. PMID 9326583 DOI: 10.1073/pnas.94.21.11184  1
1997 Gibson RM, Ji-Buechler Y, Taylor SS. Identification of electrostatic interaction sites between the regulatory and catalytic subunits of cyclic AMP-dependent protein kinase Protein Science. 6: 1825-1834. PMID 9300482 DOI: 10.1002/PRO.5560060903  1
1997 McCormick SP, Ng JK, Cham CM, Taylor S, Marcovina SM, Segrest JP, Hammer RE, Young SG. Transgenic mice expressing human ApoB95 and ApoB97. Evidence that sequences within the carboxyl-terminal portion of human apoB100 are important for the assembly of lipoprotein. The Journal of Biological Chemistry. 272: 23616-22. PMID 9295301 DOI: 10.1074/jbc.272.38.23616  1
1997 Narayana N, Cox S, Xuong NH, Ten Eyck LF, Taylor SS. A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility Structure. 5: 921-935. PMID 9261084 DOI: 10.1016/S0969-2126(97)00246-3  1
1997 Gibson RM, Ji-Buechler Y, Taylor SS. Interaction of the regulatory and catalytic subunits of cAMP-dependent protein kinase: Electrostatic sites on the type Iα regulatory subunit Journal of Biological Chemistry. 272: 16343-16350. PMID 9195940 DOI: 10.1074/jbc.272.26.16343  1
1997 Lew J, Taylor SS, Adams JA. Identification of a partially rate-determining step in the catalytic mechanism of cAMP-dependent protein kinase: a transient kinetic study using stopped-flow fluorescence spectroscopy. Biochemistry. 36: 6717-24. PMID 9184152 DOI: 10.1021/bi963164u  1
1997 Narayana N, Cox S, Shaltiel S, Taylor SS, Xuong NH. Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of camp-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine Biochemistry. 36: 4438-4448. PMID 9109651 DOI: 10.1021/bi961947+  1
1997 Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS. Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits. The Journal of Biological Chemistry. 272: 8057-64. PMID 9065479 DOI: 10.1074/jbc.272.12.8057  1
1997 Hemmer W, McGlone M, Taylor SS. Recombinant strategies for rapid purification of catalytic subunits of cAMP-dependent protein kinase Analytical Biochemistry. 245: 115-122. PMID 9056191 DOI: 10.1006/abio.1996.9952  1
1997 Lew J, Coruh N, Tsigelny I, Garrod S, Taylor SS. Synergistic binding of nucleotides and inhibitors to cAMP-dependent protein kinase examined by acrylodan fluorescence spectroscopy Journal of Biological Chemistry. 272: 1507-1513. PMID 8999821 DOI: 10.1074/jbc.272.3.1507  1
1996 Tsigelny I, Grant BD, Taylor SS, Ten Eyck LF. Catalytic subunit of cAMP-dependent protein kinase: Electrostatic features and peptide recognition Biopolymers. 39: 353-365. PMID 8756515 DOI: 10.1002/(SICI)1097-0282(199609)39:3<353::AID-BIP7>3.0.CO;2-N  1
1996 Herberg FW, Taylor SS, Dostmann WRG. Active site mutations define the pathway for the cooperative activation of cAMP-dependent protein kinase Biochemistry. 35: 2934-2942. PMID 8608131 DOI: 10.1021/bi951647c  1
1995 Cox S, Taylor SS. Kinetic analysis of cAMP-dependent protein kinase: Mutations at histidine 87 affect peptide binding and pH dependence Biochemistry. 34: 16203-16209. PMID 8519778 DOI: 10.1021/bi00049a036  1
1995 Adams JA, McGlone ML, Gibson R, Taylor SS. Phosphorylation modulates catalytic function and regulation in the cAMP-dependent protein kinase. Biochemistry. 34: 2447-54. PMID 7873523 DOI: 10.1021/bi00008a007  1
1995 Wen W, Meinkotht JL, Tsien RY, Taylor SS. Identification of a signal for rapid export of proteins from the nucleus Cell. 82: 463-473. PMID 7634336 DOI: 10.1016/0092-8674(95)90435-2  1
1995 Durick K, Yao VJ, Borrello MG, Bongarzone I, Pierotti MA, Taylor SS. Tyrosines outside the kinase core and dimerization are required for the mitogenic activity of RET/ptc2. The Journal of Biological Chemistry. 270: 24642-5. PMID 7559572 DOI: 10.1074/jbc.270.42.24642  1
1995 Taylor SS, Radzio-Andzelm E, Hunter T. How do protein kinases discriminate between serine/threonine and tyrosine? Structural insights from the insulin receptor protein-tyrosine kinase Faseb Journal. 9: 1255-1266. PMID 7557015 DOI: 10.1096/fasebj.9.13.7557015  1
1994 Brooks AR, Nagy BP, Taylor S, Simonet WS, Taylor JM, Levy-Wilson B. Sequences containing the second-intron enhancer are essential for transcription of the human apolipoprotein B gene in the livers of transgenic mice. Molecular and Cellular Biology. 14: 2243-56. PMID 8139530  1
1994 Taylor SS, Radzio-Andzelm E. Three protein kinase structures define a common motif Structure. 2: 345-355. PMID 8081750 DOI: 10.1016/S0969-2126(00)00036-8  1
1994 Cox S, Radzio-Andzelm E, Taylor SS. Domain movements in protein kinases Current Opinion in Structural Biology. 4: 893-901. PMID 7712293 DOI: 10.1016/0959-440X(94)90272-0  1
1993 Su Y, Taylor SS, Dostmann WRG, Xuong NH, Varughese KI. Crystallization of a deletion mutant of the R-subunit of cAMP dependent protein kinase Journal of Molecular Biology. 230: 1091-1093. PMID 8478923 DOI: 10.1006/JMBI.1993.1224  1
1993 Marcote MJ, Knighton DR, Basi G, Sowadski JM, Brambilla P, Draetta G, Taylor SS. A three-dimensional model of the Cdc2 protein kinase: localization of cyclin- and Suc1-binding regions and phosphorylation sites. Molecular and Cellular Biology. 13: 5122-31. PMID 8336738 DOI: 10.1128/MCB.13.8.5122  0.4
1993 Adams JA, Taylor SS. Divalent metal ions influence catalysis and active-site accessibility in the cAMP-dependent protein kinase. Protein Science : a Publication of the Protein Society. 2: 2177-86. PMID 8298463 DOI: 10.1002/pro.5560021217  1
1993 Herberg FW, Taylor SS. Physiological inhibitors of the catalytic subunit of cAMP-dependent protein kinase: Effect of MgATP on protein-protein interactions Biochemistry. 32: 14015-14022. PMID 8268180 DOI: 10.1021/bi00213a035  1
1993 Herberg FW, Bell SM, Taylor SS. Expression of the catalytic subunit of camp-dependent protein kinase in Escherichia coli: Multiple isozymes reflect different phosphorylation states Protein Engineering, Design and Selection. 6: 771-777. PMID 8248101 DOI: 10.1093/protein/6.7.771  1
1993 Meinkoth JL, Alberts AS, Went W, Fantozzi D, Taylor SS, Hagiwara M, Montminy M, Feramisco JR. Signal transduction through the cAMP-dependent protein kinase. Molecular and Cellular Biochemistry. 127: 179-86. PMID 7935349 DOI: 10.1007/BF01076769  1
1992 Zheng JH, Knighton DR, Xuong NH, Parello J, Taylor SS, Sowadski JM. Crystallization studies of the catalytic subunit of cAMP-dependent protein kinase: crystals of murine recombinant catalytic subunit and a mutant, Cys 343----Ser, diffract to 2.7 A resolution Acta Crystallographica. Section B, Structural Science. 48. PMID 1515113 DOI: 10.1107/S0108768192000909  1
1992 Knighton DR, Pearson RB, Sowadski JM, Means AR, Ten Eyck LF, Taylor SS, Kemp BE. Structural basis of the intrasteric regulation of myosin light chain kinases. Science (New York, N.Y.). 258: 130-5. PMID 1439761  1
1992 Adams JA, Taylor SS. Energetic limits of phosphotransfer in the catalytic subunit of cAMP-dependent protein kinase as measured by viscosity experiments. Biochemistry. 31: 8516-22. PMID 1390637 DOI: 10.1021/BI00151A019  1
1992 Mann SKO, Yonemoto WM, Taylor SS, Firtel RA. DdPK3, which plays essential roles during Dictyostelium development, encodes the catalytic subunit of cAMP-dependent protein kinase Proceedings of the National Academy of Sciences of the United States of America. 89: 10701-10705. PMID 1332055 DOI: 10.1073/pnas.89.22.10701  1
1992 Taylor SS, Adams JA. Protein kinases: coming of age Current Opinion in Structural Biology. 2: 743-748. DOI: 10.1016/0959-440X(92)90210-X  1
1991 Zoller MJ, Yonemoto W, Taylor SS, Johnson KE. Mammalian cAMP-dependent protein kinase functionally replaces its homolog in yeast Gene. 99: 171-179. PMID 2022331 DOI: 10.1016/0378-1119(91)90124-T  1
1991 Buechler JA, Toner-Webb JA, Taylor SS. Carbodiimides as probes for protein kinase structure and function Methods in Enzymology. 200: 487-500. PMID 1956333 DOI: 10.1016/0076-6879(91)00165-S  1
1991 Knighton DR, Zheng J, Ten Eyck LF, Xuong N, Taylor SS, Sowadski JM. Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase Science. 253: 414-420. PMID 1862343 DOI: 10.1126/SCIENCE.1862343  1
1991 Knighton DR, Xuong NH, Taylor SS, Sowadski JM. Crystallization studies of cAMP-dependent protein kinase. Cocrystals of the catalytic subunit with a 20 amino acid residue peptide inhibitor and MgATP diffract to 3.0 Å resolution Journal of Molecular Biology. 220: 217-220. PMID 1856856 DOI: 10.1016/0022-2836(91)90005-Q  1
1991 Adams SR, Harootunian AT, Buechler YJ, Taylor SS, Tsien RY. Fluorescence ratio imaging of cyclic AMP in single cells Nature. 349: 694-697. PMID 1847505  1
1990 Duronio RJ, Jackson-Machelski E, Heuckeroth RO, Olins PO, Devine CS, Yonemoto W, Slice LW, Taylor SS, Gordon JI. Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein modification in bacteria. Proceedings of the National Academy of Sciences of the United States of America. 87: 1506-10. PMID 2406721  1
1990 Meinkoth JL, Ji Y, Taylor SS, Feramisco JR. Dynamics of the distribution of cyclic AMP-dependent protein kinase in living cells. Proceedings of the National Academy of Sciences of the United States of America. 87: 9595-9. PMID 2263615 DOI: 10.1073/pnas.87.24.9595  1
1990 Taylor SS, Buechler JA, Yonemoto W. cAMP-dependent protein kinase: Framework for a diverse family of regulatory enzymes Annual Review of Biochemistry. 59: 971-1105. PMID 2165385 DOI: 10.1146/ANNUREV.BI.59.070190.004543  1
1989 First EA, Taylor SS. Selective modification of the catalytic subunit of cAMP-dependent protein kinase with sulfhydryl-specific fluorescent probes Biochemistry. 28: 3598-3605. PMID 2742857 DOI: 10.1021/BI00434A067  1
1989 Taylor SS. cAMP-dependent protein kinase. Model for an enzyme family Journal of Biological Chemistry. 264: 8443-8446. PMID 2656679 DOI: 10.1016/B978-012124546-7/50560-X  1
1989 Buechler JA, Vedvick TA, Taylor SS. Differential labeling of the catalytic subunit of cAMP-dependent protein kinase with acetic anhydride: Substrate-induced conformational changes Biochemistry. 28: 3018-3024. PMID 2500968 DOI: 10.1021/BI00433A042  1
1989 Buechler JA, Taylor SS. Dicyclohexylcarbodiimide cross-links two conserved residues, Asp-184 and Lys-72, at the active site of the catalytic subunit of cAMP-dependent protein kinase Biochemistry. 28: 2065-2070. PMID 2497773 DOI: 10.1021/BI00431A015  1
1988 First EA, Bubis J, Taylor SS. Subunit interaction sites between the regulatory and catalytic subunits of cAMP-dependent protein kinase. Identification of a specific interchain disulfide bond. The Journal of Biological Chemistry. 263: 5176-82. PMID 3356685  1
1988 Taylor SS, Bubis J, Toner-Webb J, Saraswat LD, First EA, Buechler JA, Knighton DR, Sowadski J. CAMP-dependent protein kinase: prototype for a family of enzymes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 2: 2677-85. PMID 3294077  1
1988 Taylor SS, Buechler JA, Slice LW, Knighton DK, Durgerian S, Ringheim GE, Neitzel JJ, Yonemoto WM, Sowadski JM, Dospmann W. cAMP-dependent protein kinase: A framework for a diverse family of enzymes Cold Spring Harbor Symposia On Quantitative Biology. 53: 121-130. PMID 3076077  1
1988 Buechler JA, Taylor SS. Identification of aspartate-184 as an essential residue in the catalytic subunit of cAMP-dependent protein kinase Biochemistry. 27: 7356-7361. PMID 2905166 DOI: 10.1021/BI00419A027  1
1988 Bubis J, Neitzel JJ, Saraswat LD, Taylor SS. A point mutation abolishes binding of cAMP to site A in the regulatory subunit of cAMP-dependent protein kinase. The Journal of Biological Chemistry. 263: 9668-73. PMID 2898473  1
1988 Ringheim GE, Saraswat LD, Bubis J, Taylor SS. Deletion of cAMP-binding site B in the regulatory subunit of cAMP-dependent protein kinase alters the photoaffinity labeling of site A. The Journal of Biological Chemistry. 263: 18247-52. PMID 2848031  1
1988 Saraswat LD, Ringheim GE, Bubis J, Taylor SS. Deletion mutants as probes for localizing regions of subunit interaction in cAMP-dependent protein kinase. The Journal of Biological Chemistry. 263: 18241-6. PMID 2848030  1
1988 Bubis J, Saraswat LD, Taylor SS. Tyrosine-371 contributes to the positive cooperativity between the two cAMP binding sites in the regulatory subunit of cAMP-dependent protein kinase I. Biochemistry. 27: 1570-6. PMID 2835094  1
1987 Bubis J, Taylor SS. Limited proteolysis alters the photoaffinity labeling of adenosine 3',5'-monophosphate dependent protein kinase II with 8-azidoadenosine 3',5'-monophosphate. Biochemistry. 26: 5997-6004. PMID 3689756  1
1987 Bubis J, Vedvick TS, Taylor SS. Antiparallel alignment of the two protomers of the regulatory subunit dimer of cAMP-dependent protein kinase I. The Journal of Biological Chemistry. 262: 14961-6. PMID 3667618  1
1987 Toner-Webb J, Taylor SS. Inhibition of the catalytic subunit of cAMP-dependent protein kinase by dicyclohexylcarbodiimide Biochemistry. 26: 7371-7378. PMID 3501317 DOI: 10.1021/BI00397A026  1
1987 Weber IT, Steitz TA, Bubis J, Taylor SS. Predicted structures of cAMP binding domains of type I and II regulatory subunits of cAMP-dependent protein kinase. Biochemistry. 26: 343-51. PMID 3030405 DOI: 10.1021/bi00376a003  1
1987 Bubis J, Taylor SS. Correlation of photolabeling with occupancy of cAMP binding sites in the regulatory subunit of cAMP-dependent protein kinase I. Biochemistry. 26: 3478-86. PMID 2820470  1
1986 Taylor SS, Saraswat LD, Toner JA, Bubis J. The relationship between structure and function in cAMP-dependent protein kinases. Annals of the New York Academy of Sciences. 478: 191-202. PMID 3026223  1
1985 Sowadski JM, Xuong Nh, Anderson D, Taylor SS. Crystallization studies of cAMP-dependent protein kinase. Crystals of catalytic subunit diffract to 3.5 Å resolution Journal of Molecular Biology. 182: 617-620. PMID 4009717 DOI: 10.1016/0022-2836(85)90249-9  1
1985 Dothie JM, Giglio JR, Moore CB, Taylor SS, Hartley BS. Ribitol dehydrogenase of Klebsiella aerogenes. Sequence and properties of wild-type and mutant strains. The Biochemical Journal. 230: 569-78. PMID 3904726  1
1985 Bubis J, Taylor SS. Covalent modification of both cAMP binding sites in cAMP-dependent protein kinase I by 8-azidoadenosine 3',5'-monophosphate. Biochemistry. 24: 2163-70. PMID 2986689  1
1985 Mumby MC, Weldon SL, Scott CW, Taylor SS. Monoclonal antibodies as probes of structure, function and isoenzyme forms of the type II regulatory subunit of cyclic AMP-dependent protein kinase. Pharmacology & Therapeutics. 28: 367-87. PMID 2418450 DOI: 10.1016/0163-7258(85)90059-2  1
1984 Kamps MP, Taylor SS, Sefton BM. Direct evidence that oncogenic tyrosine kinases and cyclic AMP-dependent protein kinase have homologous ATP-binding sites. Nature. 310: 589-92. PMID 6431300 DOI: 10.1038/310589a0  1
1983 Siebenaller JF, Orr TL, Olwin BB, Taylor SS. Comparison of the D-lactate stereospecific dehydrogenase of Limulus polyphemus with active-site regions of L-lactate dehydrogenases. Biochimica Et Biophysica Acta. 749: 153-62. PMID 6652095 DOI: 10.1016/0167-4838(83)90247-9  1
1978 Potter RL, Stafford PH, Taylor S. Regulatory subunit of cyclic AMP-dependent protein kinase I from porcine skeletal muscle: purification and proteolysis. Archives of Biochemistry and Biophysics. 190: 174-80. PMID 213029 DOI: 10.1016/0003-9861(78)90265-5  1
1977 Taylor SS. Amino acid sequence of dogfish muscle lactate dehydrogenase Journal of Biological Chemistry. 252: 1799-1806. PMID 838743  1
1977 Eventoff W, Rossmann MG, Taylor SS, Torff HJ, Meyer H, Keil W, Kiltz HH. Structural adaptations of lactate dehydrogenase isozymes Proceedings of the National Academy of Sciences of the United States of America. 74: 2677-2681. PMID 197516 DOI: 10.1073/pnas.74.7.2677  1
1976 Taylor SS, Oxley SS. Homologies in the active site regions of lactate dehydrogenases Archives of Biochemistry and Biophysics. 175: 373-383. PMID 962329 DOI: 10.1016/0003-9861(76)90524-5  1
1976 Taylor SS, Lee CY, Swain L, Stafford PH. Cyclic AMP-dependent protein kinase: Purification of the holoenzyme by affinity chromatography Analytical Biochemistry. 76: 45-52. PMID 187080 DOI: 10.1016/0003-2697(76)90262-1  1
1975 Taylor SS, Allison WS, Kaplan NO. The amino acid sequence of the tryptic peptides isolated from dogfish M4 lactate dehydrogenase. The Journal of Biological Chemistry. 250: 8740-7. PMID 1184589  1
1974 Taylor SS, Rigby PW, Hartley BS. Ribitol dehydrogenase from Klebsiella aerogenes. Purification and subunit structure. The Biochemical Journal. 141: 693-700. PMID 4618776  1
1974 Kaplan NO, Everse J, Dixon JE, Stolzenbach FE, Lee CY, Lee CL, Taylor SS, Mosbach K. Purification and separation of pyridine nucleotide-linked dehydrogenases by affinity chromatography techniques. Proceedings of the National Academy of Sciences of the United States of America. 71: 3450-4. PMID 4372619 DOI: 10.1073/pnas.71.9.3450  1
1973 Taylor SS, Oxley SS, Allison WS, Kaplan NO. Aminoacid sequence of dogfish M4 lactate dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America. 70: 1790-3. PMID 4515938  1
1973 Adams MJ, Buehner M, Chandrasekhar K, Ford GC, Hackert ML, Liljas A, Rossmann MG, Smiley IE, Allison WS, Everse J, Kaplan NO, Taylor SS. Structure-function relationships in lactate dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America. 70: 1968-72. PMID 4146647 DOI: 10.1073/pnas.70.7.1968  1
1969 Taylor SS, Heath EC. The incorporation of beta-hydroxy fatty acids into a phospholipid of Escherichia coli B. The Journal of Biological Chemistry. 244: 6605-16. PMID 4902888  1
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