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Susan Serota Taylor - Publications

Affiliations: 
University of California, San Diego, La Jolla, CA 
Area:
Structure, Function, Dynamics, and Localization of PKA as a Prototype for the Protein Kinase Superfamily
Website:
http://www-chem.ucsd.edu/faculty/profiles/taylor_susan_s.html
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Year Citation  Score
2024 Kaila Sharma P, Weng JH, Manschwetus JT, Wu J, Ma W, Herberg FW, Taylor S. Role of the LRRK2 C-terminal tail in domain crosstalk. The Biochemical Journal. PMID 38305364 DOI: 10.1042/BCJ20230477  0.403
2023 Hardy JC, Pool EH, Bruystens JGH, Zhou X, Li Q, Zhou DR, Palay M, Tan G, Chen L, Choi JLC, Lee HN, Strack S, Wang D, Taylor SS, Mehta S, et al. Molecular Determinants and Signaling Effects of PKA RIα Phase Separation. Biorxiv : the Preprint Server For Biology. PMID 38168176 DOI: 10.1101/2023.12.10.570836  0.391
2023 Kornev AP, Weng JH, Maillard RA, Taylor SS. Gauging Dynamics-driven Allostery Using a New Computational Tool: A CAP Case Study. Journal of Molecular Biology. 436: 168395. PMID 38097109 DOI: 10.1016/j.jmb.2023.168395  0.317
2023 Olivieri C, Wang Y, Walker C, Subrahmanian MV, Ha KN, Bernlohr DA, Gao J, Camilloni C, Vendruscolo M, Taylor SS, Veglia G. The αC-β4 loop controls the allosteric cooperativity between nucleotide and substrate in the catalytic subunit of protein kinase A. Biorxiv : the Preprint Server For Biology. PMID 37745542 DOI: 10.1101/2023.09.12.557419  0.402
2023 Wu J, Jonniya NA, Hirakis SP, Olivieri C, Veglia G, Kornev AP, Taylor SS. Protein Kinase Structure and Dynamics: Role of the αC-β4 Loop. Biorxiv : the Preprint Server For Biology. PMID 37693538 DOI: 10.1101/2023.08.31.555822  0.396
2023 Störmer E, Weng JH, Wu J, Bertinetti D, Kaila Sharma P, Ma W, Herberg FW, Taylor S. Capturing the domain crosstalk in full length LRRK2 and LRRK2RCKW. The Biochemical Journal. PMID 37212165 DOI: 10.1042/BCJ20230126  0.39
2023 Lev-Ram V, Lemieux SP, Deerinck TJ, Bushong EA, Toyama BH, Perez A, Pritchard DR, Park SKR, McClatchy DB, Savas JN, Taylor SS, Ellisman MH, Yates J, Tsien RY. Do perineuronal nets stabilize the engram of a synaptic circuit? Biorxiv : the Preprint Server For Biology. PMID 37066274 DOI: 10.1101/2023.04.09.536164  0.335
2023 Weng JH, Ma W, Wu J, Sharma PK, Silletti S, McCammon JA, Taylor S. Capturing Differences in the Regulation of LRRK2 Dynamics and Conformational States by Small Molecule Kinase Inhibitors. Acs Chemical Biology. PMID 37043829 DOI: 10.1021/acschembio.2c00868  0.431
2023 Olivieri C, Walker C, Veliparambil Subrahmanian M, Porcelli F, Taylor SS, Bernlohr DA, Veglia G. An NMR portrait of functional and dysfunctional allosteric cooperativity in cAMP-dependent protein kinase A. Febs Letters. PMID 36892429 DOI: 10.1002/1873-3468.14610  0.475
2023 Taylor SS, Herberg FW, Veglia G, Wu J. Edmond Fischer's kinase legacy: History of the protein kinase inhibitor and protein kinase A. Iubmb Life. PMID 36855225 DOI: 10.1002/iub.2714  0.5
2023 Weng JH, Trilling C, Kaila Sharma P, Störmer E, Wu J, Herberg FW, Taylor SS. Novel LRR-ROC motif that links the N- and C-terminal Domains in LRRK2 undergoes an order-disorder transition upon activation. Journal of Molecular Biology. 167999. PMID 36764356 DOI: 10.1016/j.jmb.2023.167999  0.397
2022 Kornev AP, Aoto PC, Taylor SS. Calculation of centralities in protein kinase A. Proceedings of the National Academy of Sciences of the United States of America. 119: e2215420119. PMID 36375071 DOI: 10.1073/pnas.2215420119  0.33
2022 Happ JT, Arveseth CD, Bruystens J, Bertinetti D, Nelson IB, Olivieri C, Zhang J, Hedeen DS, Zhu JF, Capener JL, Bröckel JW, Vu L, King CC, Ruiz-Perez VL, Ge X, ... ... Taylor SS, et al. A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction. Nature Structural & Molecular Biology. PMID 36202993 DOI: 10.1038/s41594-022-00838-z  0.346
2022 Pilo CA, Baffi TR, Kornev AP, Kunkel MT, Malfavon M, Chen DH, Rossitto LA, Chen DX, Huang LC, Longman C, Kannan N, Raskind WH, Gonzalez DJ, Taylor SS, Gorrie G, et al. Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition. Science Signaling. 15: eabk1147. PMID 36166510 DOI: 10.1126/scisignal.abk1147  0.316
2022 Olivieri C, Li GC, Wang Y, V S M, Walker C, Kim J, Camilloni C, De Simone A, Vendruscolo M, Bernlohr DA, Taylor SS, Veglia G. ATP-competitive inhibitors modulate the substrate binding cooperativity of a kinase by altering its conformational entropy. Science Advances. 8: eabo0696. PMID 35905186 DOI: 10.1126/sciadv.abo0696  0.404
2022 Weng JH, Aoto PC, Lorenz R, Wu J, Schmidt SH, Manschwetus JT, Kaila-Sharma P, Silletti S, Mathea S, Chatterjee D, Knapp S, Herberg FW, Taylor SS. LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains. Plos Biology. 20: e3001427. PMID 35192607 DOI: 10.1371/journal.pbio.3001427  0.399
2022 Alexa A, Sok P, Gross F, Albert K, Kobori E, Póti ÁL, Gógl G, Bento I, Kuang E, Taylor SS, Zhu F, Ciliberto A, Reményi A. A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host. Nature Communications. 13: 472. PMID 35078976 DOI: 10.1038/s41467-022-28109-x  0.42
2021 Roa JN, Ma Y, Mikulski Z, Xu Q, Ilouz R, Taylor SS, Skowronska-Krawczyk D. Protein Kinase A in Human Retina: Differential Localization of Cβ, Cα, RIIα, and RIIβ in Photoreceptors Highlights Non-redundancy of Protein Kinase A Subunits. Frontiers in Molecular Neuroscience. 14: 782041. PMID 34867193 DOI: 10.3389/fnmol.2021.782041  0.31
2021 Lorenz R, Wu J, Herberg FW, Taylor SS, Engh RA. Drugging the Undruggable: How Isoquinolines and PKA Initiated the Era of Designed Protein Kinase Inhibitor Therapeutics. Biochemistry. PMID 34370450 DOI: 10.1021/acs.biochem.1c00359  0.439
2021 Taylor SS, Søberg K, Kobori E, Wu J, Pautz S, Herberg FW, Skålhegg BS. The tails of PKA. Molecular Pharmacology. PMID 34330820 DOI: 10.1124/molpharm.121.000315  0.391
2021 Walker C, Wang Y, Olivieri C, V S M, Gao J, Bernlohr DA, Calebiro D, Taylor SS, Veglia G. Is disrupted nucleotide-substrate cooperativity a common trait for Cushing's syndrome driving mutations of protein kinase A? Journal of Molecular Biology. 167123. PMID 34224748 DOI: 10.1016/j.jmb.2021.167123  0.349
2021 Taylor SS, Wallbott M, Machal EMF, Søberg K, Ahmed F, Bruystens J, Vu L, Baker B, Wu J, Raimondi F, Ongeri EM, Herberg FW, Skålhegg BS. PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies. The Biochemical Journal. 478: 2101-2119. PMID 34115095 DOI: 10.1042/BCJ20200867  0.385
2021 Schmidt SH, Weng JH, Aoto PC, Boassa D, Mathea S, Silletti S, Hu J, Wallbott M, Komives EA, Knapp S, Herberg FW, Taylor SS. Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34088839 DOI: 10.1073/pnas.2100844118  0.397
2021 Jafari N, Del Rio J, Akimoto M, Byun JA, Boulton S, Moleschi K, Alsayyed Y, Swanson P, Huang J, Martinez Pomier K, Lee C, Wu J, Taylor SS, Melacini G. Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34006641 DOI: 10.1073/pnas.2024716118  0.357
2021 Taylor SS, Wu J, Bruystens JGH, Del Rio JC, Lu TW, Kornev AP, Ten Eyck LF. From structure to the dynamic regulation of a molecular switch: A journey over three decades. The Journal of Biological Chemistry. 100746. PMID 33957122 DOI: 10.1016/j.jbc.2021.100746  0.837
2021 Baffi TR, Lordén G, Wozniak JM, Feichtner A, Yeung W, Kornev AP, King CC, Del Rio JC, Limaye AJ, Bogomolovas J, Gould CM, Chen J, Kennedy EJ, Kannan N, Gonzalez DJ, ... ... Taylor SS, et al. mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif. Science Signaling. 14. PMID 33850054 DOI: 10.1126/scisignal.abe4509  0.406
2021 Olivieri C, Walker C, Karamafrooz A, Wang Y, Manu VS, Porcelli F, Blumenthal DK, Thomas DD, Bernlohr DA, Simon SM, Taylor SS, Veglia G. Author Correction: Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A. Communications Biology. 4: 446. PMID 33824409 DOI: 10.1038/s42003-021-02006-3  0.37
2021 Olivieri C, Walker C, Karamafrooz A, Wang Y, Manu VS, Porcelli F, Blumenthal DK, Thomas DD, Bernlohr DA, Sandford SM, Taylor SS, Veglia G. Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A. Communications Biology. 4: 321. PMID 33692454 DOI: 10.1038/s42003-021-01819-6  0.486
2020 Lu TW, Aoto PC, Weng JH, Nielsen C, Cash JN, Hall J, Zhang P, Simon SM, Cianfrocco MA, Taylor SS. Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma. Plos Biology. 18: e3001018. PMID 33370777 DOI: 10.1371/journal.pbio.3001018  0.851
2020 Jones AC, Taylor SS, Newton AC, Kornev AP. Hypothesis: Unifying model of domain architecture for conventional and novel protein kinase C isozymes. Iubmb Life. PMID 33166426 DOI: 10.1002/iub.2401  0.406
2020 Taylor SS, Kaila-Sharma P, Weng JH, Aoto P, Schmidt SH, Knapp S, Mathea S, Herberg FW. Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery. Frontiers in Molecular Neuroscience. 13: 538219. PMID 33122997 DOI: 10.3389/fnmol.2020.538219  0.424
2020 Zhang JZ, Lu TW, Stolerman LM, Tenner B, Yang JR, Zhang JF, Falcke M, Rangamani P, Taylor SS, Mehta S, Zhang J. Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling. Cell. PMID 32846158 DOI: 10.1016/J.Cell.2020.07.043  0.816
2020 Watanabe R, Buschauer R, Böhning J, Audagnotto M, Lasker K, Lu TW, Boassa D, Taylor S, Villa E. The In Situ Structure of Parkinson's Disease-Linked LRRK2. Cell. PMID 32783917 DOI: 10.1016/J.Cell.2020.08.004  0.819
2020 Byun JA, Akimoto M, VanSchouwen B, Lazarou TS, Taylor SS, Melacini G. Allosteric pluripotency as revealed by protein kinase A. Science Advances. 6: eabb1250. PMID 32596469 DOI: 10.1126/Sciadv.Abb1250  0.515
2020 Olivieri C, Wang Y, Li GC, Subrahmanian MV, Kim J, Stultz BR, Neibergall M, Porcelli F, Muretta JM, T Thomas DD, Gao J, Blumenthal DK, Taylor SS, Veglia G. Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A. Elife. 9. PMID 32338601 DOI: 10.7554/Elife.55607  0.563
2020 Gerlits O, Weiss KL, Blakeley MP, Veglia G, Taylor SS, Kovalevsky A. Protein kinase A in the neutron beam: Insights for catalysis from directly observing protons. Methods in Enzymology. 634: 311-331. PMID 32093838 DOI: 10.1016/Bs.Mie.2019.12.003  0.534
2020 Olivieri C, Wang Y, Li GC, S MV, Kim J, Stultz BR, Neibergall M, Porcelli F, Muretta JM, Thomas DD, Gao J, Blumenthal DK, Taylor SS, Veglia G. Author response: Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A Elife. DOI: 10.7554/Elife.55607.Sa2  0.456
2020 Taylor SS, Kaila-Sharma P, Weng J, Aoto P, Schmidt SH, Knapp S, Mathea S, Herberg FW. Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery Frontiers in Molecular Neuroscience. 13. DOI: 10.3389/fnmol.2020.538219  0.338
2020 Aoto P, Baker B, Taylor S. Protein Kinase A isoform dynamics and disease. The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.06840  0.447
2020 Lu T, Wu J, Aoto P, Weng J, Ahuja LG, Sun N, Taylor S. PKA RIα Holoenzyme Structure Reveals ATP‐Dependent Dynamics and Allosteric Regulation in Isoform‐Specific Manner The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.06626  0.738
2020 Weng J, Auto P, Lu T, Taylor S. The structure of LRRK2 and the conformational changes that are associated with LRRK2 activation and Parkinson’s disease pathogenesis The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.06015  0.708
2020 Del-rio J, Wu L, Lu T, Aoto P, Taylor SS. Functional and Structural Characterization of Acrodysostosis Mutations of PKA RIα Reveals Mechanism Causing resistant to cAMP activation The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05949  0.72
2020 Pilo CA, Kunkel MT, Van AN, Kobori EK, Kornev AP, Longman C, Gorrie G, Taylor SS, Newton AC. Impaired Autoinhibition of Protein Kinase Cγ in Spinocerebellar Ataxia Type 14 Biophysical Journal. 118: 535a. DOI: 10.1096/Fasebj.2020.34.S1.04177  0.462
2020 Pilo CA, Kunkel MT, Van AN, Kobori EK, Longman C, Gorrie G, Taylor SS, Newton AC. Impaired Autoinhibition of Protein Kinase Cγ in Spinocerebellar Ataxia Type 14 The Faseb Journal. 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.04177  0.355
2020 Zhang JZ, Lu T, Tenner B, Yang J, Zhang J, Taylor S, Mehta S, Zhang J. PKA RIα phase separation drives cAMP compartmentation and suppresses tumorigenic signaling The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.03204  0.699
2020 Aoto PC, Taylor SS. Dynamic Disease Landscape of a Cancer Driving Fusion Kinase Biophysical Journal. 118: 522a. DOI: 10.1016/J.Bpj.2019.11.2869  0.346
2020 Vu L, Taylor SS, Aoto PC, Weng J. Structural and Dynamic Effects of Phosphorylation of Protein Kinase a Catalytic Subunit Biophysical Journal. 118: 354a. DOI: 10.1016/J.Bpj.2019.11.2041  0.534
2020 Lu T, Taylor SS. Two PKA RIA Holoenzyme Structural States Define ATP as an Isoform Specific Orthosteric Inhibitor that Competes with Allosteric Activator, ATP Biophysical Journal. 118: 354a. DOI: 10.1016/J.Bpj.2019.11.2039  0.753
2020 Kobori E, Alexa A, Remenyi A, Taylor SS. Conformations of P90 Ribosomal S6 Kinase Activation Biophysical Journal. 118: 336a. DOI: 10.1016/J.Bpj.2019.11.1873  0.4
2019 Haushalter KJ, Schilling JM, Song Y, Sastri M, Perkins GA, Strack S, Taylor SS, Patel HH. Cardiac ischemia/reperfusion injury induces ROS-dependent loss of PKA regulatory subunit RIα. American Journal of Physiology. Heart and Circulatory Physiology. PMID 31674811 DOI: 10.1152/Ajpheart.00237.2019  0.382
2019 Walker C, Wang Y, Olivieri C, Karamafrooz A, Casby J, Bathon K, Calebiro D, Gao J, Bernlohr DA, Taylor SS, Veglia G. Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity. Science Advances. 5: eaaw9298. PMID 31489371 DOI: 10.1126/Sciadv.Aaw9298  0.499
2019 Hao Y, England JP, Bellucci L, Paci E, Hodges HC, Taylor SS, Maillard RA. Activation of PKA via asymmetric allosteric coupling of structurally conserved cyclic nucleotide binding domains. Nature Communications. 10: 3984. PMID 31484930 DOI: 10.1038/S41467-019-11930-2  0.487
2019 Röck R, Mayrhofer JE, Torres-Quesada O, Enzler F, Raffeiner A, Raffeiner P, Feichtner A, Huber RG, Koide S, Taylor SS, Troppmair J, Stefan E. BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS. Science Advances. 5: eaav8463. PMID 31453322 DOI: 10.1126/Sciadv.Aav8463  0.381
2019 Lu TW, Wu J, Aoto PC, Weng JH, Ahuja LG, Sun N, Cheng CY, Zhang P, Taylor SS. Two PKA RIα holoenzyme states define ATP as an isoform-specific orthosteric inhibitor that competes with the allosteric activator, cAMP. Proceedings of the National Academy of Sciences of the United States of America. PMID 31363049 DOI: 10.1073/Pnas.1906036116  0.842
2019 Schmidt SH, Knape MJ, Boassa D, Mumdey N, Kornev AP, Ellisman MH, Taylor SS, Herberg FW. The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain. Proceedings of the National Academy of Sciences of the United States of America. PMID 31292254 DOI: 10.1073/Pnas.1900289116  0.64
2019 Ahuja LG, Aoto PC, Kornev AP, Veglia G, Taylor SS. Dynamic allostery-based molecular workings of kinase:peptide complexes. Proceedings of the National Academy of Sciences of the United States of America. PMID 31285328 DOI: 10.1073/Pnas.1900163116  0.493
2019 Jewell JL, Fu V, Hong AW, Yu FX, Meng D, Melick CH, Wang H, Lam WM, Yuan HX, Taylor SS, Guan KL. GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. Elife. 8. PMID 31112131 DOI: 10.7554/Elife.43038  0.434
2019 Ahuja LG, Taylor SS, Kornev AP. Tuning the "violin" of protein kinases: The role of dynamics-based allostery. Iubmb Life. PMID 31063633 DOI: 10.1002/Iub.2057  0.488
2019 Taylor SS, Meharena HS, Kornev AP. Evolution of a Dynamic Molecular Switch. Iubmb Life. PMID 31059206 DOI: 10.1002/Iub.2059  0.541
2019 Gerlits O, Weiss KL, Blakeley MP, Veglia G, Taylor SS, Kovalevsky A. Zooming in on protons: Neutron structure of protein kinase A trapped in a product complex. Science Advances. 5: eaav0482. PMID 30906862 DOI: 10.1126/Sciadv.Aav0482  0.53
2019 Cao B, Lu TW, Martinez Fiesco JA, Tomasini M, Fan L, Simon SM, Taylor SS, Zhang P. Structures of the PKA RIα Holoenzyme with the FLHCC Driver J-PKAcα or Wild-Type PKAcα. Structure (London, England : 1993). PMID 30905674 DOI: 10.1016/J.Str.2019.03.001  0.846
2019 Wang Y, V S M, Kim J, Li G, Ahuja LG, Aoto P, Taylor SS, Veglia G. Globally correlated conformational entropy underlies positive and negative cooperativity in a kinase's enzymatic cycle. Nature Communications. 10: 799. PMID 30778078 DOI: 10.1038/S41467-019-08655-7  0.483
2019 Zhang P, Fan Y, Ru H, Wang L, Magupalli VG, Taylor SS, Alessi DR, Wu H. Crystal structure of the WD40 domain dimer of LRRK2. Proceedings of the National Academy of Sciences of the United States of America. PMID 30635421 DOI: 10.2210/Pdb6Dlo/Pdb  0.497
2019 Gógl G, Kornev AP, Reményi A, Taylor SS. Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores. Trends in Biochemical Sciences. PMID 30611608 DOI: 10.1016/J.Tibs.2018.12.002  0.516
2019 Jewell JL, Fu V, Hong AW, Yu F, Meng D, Melick CH, Wang H, Lam WM, Yuan H, Taylor SS, Guan K. Author response: GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor Elife. DOI: 10.7554/Elife.43038.019  0.365
2018 Adame-García SR, Cervantes-Villagrana RD, Orduña-Castillo LB, Del Rio JC, Gutkind JS, Reyes-Cruz G, Taylor SS, Vázquez-Prado J. cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits. The Journal of Biological Chemistry. PMID 30530493 DOI: 10.1074/Jbc.Ra118.006691  0.425
2018 Meng Y, Ahuja LG, Kornev AP, Taylor SS, Roux B. Corrigendum to "A Catalytically-Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation." J. Mol. Biol. 430(6) (Mar 16 2018), 881-889. Journal of Molecular Biology. PMID 30220583 DOI: 10.1016/J.Jmb.2018.09.001  0.442
2018 Raju S, Whalen DM, Mengistu M, Swanson C, Quinn JG, Taylor SS, Webster JD, Newton K, Shaw AS. Kinase domain dimerization drives RIPK3-dependent necroptosis. Science Signaling. 11. PMID 30131368 DOI: 10.1126/Scisignal.Aar2188  0.498
2018 Flippo KH, Gnanasekaran A, Perkins GA, Ahmad A, Merrill RA, Dickey AS, Taylor SS, McKnight GS, Chauhan AK, Usachev YM, Strack S. AKAP1 protects from cerebral ischemic stroke by inhibiting Drp1-dependent mitochondrial fission. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30093535 DOI: 10.1523/Jneurosci.0649-18.2018  0.322
2018 England JP, Hao Y, Bai L, Glick V, Hodges HC, Taylor SS, Maillard RA. Switching of the folding-energy landscape governs the allosteric activation of protein kinase A. Proceedings of the National Academy of Sciences of the United States of America. PMID 30038016 DOI: 10.1073/Pnas.1802510115  0.533
2018 Meng Y, Ahuja LG, Kornev AP, Taylor SS, Roux B. A Catalytically-Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation. Journal of Molecular Biology. PMID 29410316 DOI: 10.1016/J.Jmb.2018.01.019  0.507
2018 Haushalter KJ, Casteel DE, Raffeiner A, Stefan E, Patel HH, Taylor SS. Phosphorylation of Protein Kinase A (PKA) regulatory subunit RIα by Protein Kinase G (PKG) primes PKA for catalytic activity in cells. The Journal of Biological Chemistry. PMID 29378851 DOI: 10.1074/Jbc.M117.809988  0.554
2018 Tomasini MD, Wang Y, Karamafrooz A, Li G, Beuming T, Gao J, Taylor SS, Veglia G, Simon SM. Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma. Scientific Reports. 8: 720. PMID 29335433 DOI: 10.1038/S41598-017-18956-W  0.522
2018 Tomasini MD, Wang Y, Karamafrooz A, Hall J, Taylor SS, Beuming T, Veglia G, Simon SM. Abstract 4142: Conformational dynamics of the chimeric kinase DNAJB1-PRKACA, the driver for fibrolamellar hepatocellular carcinoma Cancer Research. 78: 4142-4142. DOI: 10.1158/1538-7445.Am2018-4142  0.496
2018 Ahuja LG, Meng Y, Kornev AP, Roux B, Taylor S. An Allosteric Region of Src Tyrosine Kinase Allows for Stabilization of Its Active-Like Conformation Biophysical Journal. 114: 398a. DOI: 10.1016/J.Bpj.2017.11.2201  0.438
2017 Bubis J, Martínez JC, Calabokis M, Ferreira J, Sanz-Rodríguez CE, Navas V, Escalona JL, Guo Y, Taylor SS. The gene product of a Trypanosoma equiperdum ortholog of the cAMP-dependent protein kinase regulatory subunit is a monomeric protein that is not capable of binding cyclic nucleotides. Biochimie. PMID 29288679 DOI: 10.1016/J.Biochi.2017.12.010  0.693
2017 Hao Y, Canavan C, Taylor SS, Maillard RA. Integrated Method to Attach DNA Handles and Functionally Select Proteins to Study Folding and Protein-Ligand Interactions with Optical Tweezers. Scientific Reports. 7: 10843. PMID 28883488 DOI: 10.1038/S41598-017-11214-Z  0.405
2017 Sastri M, Darshi M, Mackey M, Ramachandra R, Ju S, Phan S, Adams S, Stein K, Douglas CR, Kim JJ, Ellisman MH, Taylor SS, Perkins GA. Sub-mitochondrial localization of genetic-tagged MIB interacting partners: Mic19, Mic60 and Sam50. Journal of Cell Science. PMID 28808085 DOI: 10.1242/Jcs.201400  0.459
2017 Kim J, Ahuja LG, Chao FA, Xia Y, McClendon CL, Kornev AP, Taylor SS, Veglia G. A dynamic hydrophobic core orchestrates allostery in protein kinases. Science Advances. 3: e1600663. PMID 28435869 DOI: 10.1126/Sciadv.1600663  0.541
2017 Pecora de Barros E, Malmstrom RD, Nourbakhsh K, Del Rio JC, Kornev AP, Taylor SS, Amaro RE. Electrostatic interactions as mediators in the allosteric activation of PKA RIα. Biochemistry. PMID 28221775 DOI: 10.1021/Acs.Biochem.6B01152  0.487
2017 Ahuja LG, Kornev AP, McClendon CL, Veglia G, Taylor SS. Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer. Proceedings of the National Academy of Sciences of the United States of America. PMID 28115705 DOI: 10.1073/Pnas.1620667114  0.538
2017 Ilouz R, Lev-Ram V, Bushong EA, Stiles TL, Friedmann-Morvinski D, Douglas C, Goldberg G, Ellisman MH, Taylor SS. Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain. Elife. 6. PMID 28079521 DOI: 10.7554/Elife.17681  0.523
2017 Taylor SS, Kornev AP. PKA and the Structural Kinome Periodicum Biologorum. 118. DOI: 10.18054/Pb.V118I4.4846  0.382
2017 Lu T, Cianfrocco M, Zhang P, Taylor S. Fusion Protein, DNAJB1-PRKACA, as a Cancer Driver Biophysical Journal. 112: 489a. DOI: 10.1016/J.Bpj.2016.11.2646  0.7
2017 Kornev AP, Taylor SS. Fractal Nature of Protein Interior and its Implications for Protein Function Biophysical Journal. 112: 194a-195a. DOI: 10.1016/J.Bpj.2016.11.1079  0.358
2017 Taylor SS. PKA: Dynamic Assembly and Regulation of Macromolecular Signaling Complexes Biophysical Journal. 112: 11a. DOI: 10.1016/J.Bpj.2016.11.092  0.547
2016 Meharena HS, Fan X, Ahuja LG, Keshwani MM, McClendon CL, Chen AM, Adams JA, Taylor SS. Decoding the Interactions Regulating the Active State Mechanics of Eukaryotic Protein Kinases. Plos Biology. 14: e2000127. PMID 27902690 DOI: 10.1371/Journal.Pbio.2000127  0.502
2016 Bruystens JG, Wu J, Fortezzo A, Del Rio J, Nielsen C, Blumenthal DK, Rock R, Stefan E, Taylor SS. Structure of a PKA RIα Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation. Journal of Molecular Biology. PMID 27825928 DOI: 10.1016/J.Jmb.2016.10.033  0.509
2016 Bachmann VA, Mayrhofer JE, Ilouz R, Tschaikner P, Raffeiner P, Röck R, Courcelles M, Apelt F, Lu TW, Baillie GS, Thibault P, Aanstad P, Stelzl U, Taylor SS, Stefan E. Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 27357676 DOI: 10.1073/Pnas.1608061113  0.845
2016 Burgers PP, Bruystens J, Burnley RJ, Nikolaev VO, Keshwani M, Wu J, Janssen BJ, Taylor SS, Heck AJ, Scholten A. Structure of smAKAP and its regulation by PKA-mediated phosphorylation. The Febs Journal. PMID 27028580 DOI: 10.1111/Febs.13726  0.578
2016 Kim J, Li G, Walters MA, Taylor SS, Veglia G. Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase A. Structure (London, England : 1993). PMID 26833386 DOI: 10.1016/J.Str.2015.11.016  0.531
2016 Chávez-Vargas L, Adame-García SR, Cervantes-Villagrana RD, Castillo-Kauil A, Bruystens JG, Fukuhara S, Taylor SS, Mochizuki N, Reyes-Cruz G, Vázquez-Prado J. Protein kinase A (PKA) Type I interacts with P-Rex1, a Rac guanine nucleotide exchange factor: Effect on PKA localization and P-Rex1 signaling. The Journal of Biological Chemistry. PMID 26797121 DOI: 10.1074/Jbc.M115.712216  0.434
2016 Malmstrom RD, Kornev AP, Taylor SS, Amaro RE. Protein-Ligand Interactions through the Computational Microscope: Allostery in a Canonical Signaling Domain Biophysical Journal. 110: 52a. DOI: 10.1016/J.Bpj.2015.11.346  0.453
2016 Wang Y, Cembran A, Gao J, Veglia G, Taylor SS, Simon SM. Molecular Dynamics Simulation and Markov State Model Reveal Irregular Metastable Conformation and Allostery In DNAJB-PKAc Biophysical Journal. 110: 51a-52a. DOI: 10.1016/J.Bpj.2015.11.343  0.447
2016 Karamafrooz AN, Kim J, Li G, Simon SM, Taylor SS, Veglia G. NMR Structural/Functional Characterization of an Oncogenic Mutant of cAMP-Dependent Protein Kinase A: PRKACA-DNAJB1 Biophysical Journal. 110: 47a. DOI: 10.1016/J.Bpj.2015.11.319  0.534
2016 Li G, Olivieri C, Neibergall M, Kim J, Taylor S, Muretta J, Veglia G. Elucidating the Mechanism of Recognition and Binding of Protein Kinase Inhibitor by Protein Kinase a using NMR and Fluorescence Spectroscopy Biophysical Journal. 110: 558a. DOI: 10.1016/J.Bpj.2015.11.2984  0.584
2015 Akimoto M, McNicholl ET, Ramkissoon A, Moleschi K, Taylor SS, Melacini G. Mapping the Free Energy Landscape of PKA Inhibition and Activation: A Double-Conformational Selection Model for the Tandem cAMP-Binding Domains of PKA RIα. Plos Biology. 13: e1002305. PMID 26618408 DOI: 10.1371/Journal.Pbio.1002305  0.556
2015 Kornev AP, Taylor SS. Dynamics-Driven Allostery in Protein Kinases. Trends in Biochemical Sciences. 40: 628-47. PMID 26481499 DOI: 10.1016/J.Tibs.2015.09.002  0.471
2015 Keshwani MM, Kanter JR, Ma Y, Wilderman A, Darshi M, Insel PA, Taylor SS. Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system. Proceedings of the National Academy of Sciences of the United States of America. PMID 26417071 DOI: 10.1073/Pnas.1516057112  0.354
2015 Antal CE, Callender JA, Kornev AP, Taylor SS, Newton AC. Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII. Cell Reports. 12: 1252-60. PMID 26279568 DOI: 10.1016/J.Celrep.2015.07.039  0.5
2015 Zhang P, Ye F, Bastidas AC, Kornev AP, Wu J, Ginsberg MH, Taylor SS. An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes. Structure (London, England : 1993). PMID 26278174 DOI: 10.1016/J.Str.2015.07.007  0.811
2015 Wilderman A, Guo Y, Divakaruni AS, Perkins G, Zhang L, Murphy AN, Taylor SS, Insel PA. Proteomic and Metabolic Analyses of S49 Lymphoma Cells Reveal Novel Regulation of Mitochondria by cAMP and Protein Kinase A. The Journal of Biological Chemistry. 290: 22274-86. PMID 26203188 DOI: 10.1074/Jbc.M115.658153  0.398
2015 Knape MJ, Ahuja LG, Bertinetti D, Burghardt NC, Zimmermann B, Taylor SS, Herberg FW. Divalent Metal Ions Mg(2+) and Ca(2+) Have Distinct Effects on Protein Kinase A Activity and Regulation. Acs Chemical Biology. 10: 2303-15. PMID 26200257 DOI: 10.1021/Acschembio.5B00271  0.393
2015 Zhang P, Knape MJ, Ahuja LG, Keshwani MM, King CC, Sastri M, Herberg FW, Taylor SS. Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme. Plos Biology. 13: e1002192. PMID 26158466 DOI: 10.1371/Journal.Pbio.1002192  0.499
2015 Malmstrom RD, Kornev AP, Taylor SS, Amaro RE. Allostery through the computational microscope: cAMP activation of a canonical signalling domain. Nature Communications. 6: 7588. PMID 26145448 DOI: 10.1038/Ncomms8588  0.479
2015 Zhang P, Kornev AP, Wu J, Taylor SS. Discovery of Allostery in PKA Signaling. Biophysical Reviews. 7: 227-238. PMID 26097522 DOI: 10.1007/S12551-015-0170-X  0.559
2015 Li GC, Srivastava AK, Kim J, Taylor SS, Veglia G. Mapping the Hydrogen Bond Networks in the Catalytic Subunit of Protein Kinase A Using H/D Fractionation Factors. Biochemistry. 54: 4042-9. PMID 26030372 DOI: 10.1021/Acs.Biochem.5B00387  0.451
2015 Iglesias-Bartolome R, Torres D, Marone R, Feng X, Martin D, Simaan M, Chen M, Weinstein LS, Taylor SS, Molinolo AA, Gutkind JS. Inactivation of a Gαs-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis. Nature Cell Biology. 17: 793-803. PMID 25961504 DOI: 10.1038/Ncb3164  0.326
2015 Taylor SS, Shaw AS, Kannan N, Kornev AP. Integration of signaling in the kinome: Architecture and regulation of the αC Helix. Biochimica Et Biophysica Acta. PMID 25891902 DOI: 10.1016/J.Bbapap.2015.04.007  0.527
2015 Mohanty S, Kennedy EJ, Herberg FW, Hui R, Taylor SS, Langsley G, Kannan N. Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design. Biochimica Et Biophysica Acta. PMID 25847873 DOI: 10.1016/J.Bbapap.2015.03.012  0.44
2015 Kim J, Masterson LR, Cembran A, Verardi R, Shi L, Gao J, Taylor SS, Veglia G. Dysfunctional conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 112: 3716-21. PMID 25775607 DOI: 10.1073/Pnas.1502299112  0.549
2015 McSkimming DI, Dastgheib S, Talevich E, Narayanan A, Katiyar S, Taylor SS, Kochut K, Kannan N. ProKinO: a unified resource for mining the cancer kinome. Human Mutation. 36: 175-86. PMID 25382819 DOI: 10.1002/Humu.22726  0.429
2015 Niyitegeka JM, Bastidas AC, Newman RH, Taylor SS, Ongeri EM. Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A: significance in acute and chronic kidney injury. American Journal of Physiology. Renal Physiology. 308: F56-68. PMID 25354939 DOI: 10.1152/Ajprenal.00167.2014  0.814
2015 Hu J, Ahuja LG, Meharena HS, Kannan N, Kornev AP, Taylor SS, Shaw AS. Kinase regulation by hydrophobic spine assembly in cancer. Molecular and Cellular Biology. 35: 264-76. PMID 25348715 DOI: 10.1128/Mcb.00943-14  0.418
2015 Sarma GN, Moody IS, Ilouz R, Phan RH, Sankaran B, Hall RA, Taylor SS. D-AKAP2:PKA RII:PDZK1 ternary complex structure: insights from the nucleation of a polyvalent scaffold. Protein Science : a Publication of the Protein Society. 24: 105-16. PMID 25348485 DOI: 10.1002/Pro.2593  0.484
2015 Bastidas AC, Wu J, Taylor SS. Molecular features of product release for the PKA catalytic cycle. Biochemistry. 54: 2-10. PMID 25077557 DOI: 10.1021/Bi500684C  0.818
2015 Zhang P, Knape MJ, Ahuja LG, Keshwani MM, King CC, Sastri M, Herberg FW, Taylor SS. Endogenous RIIβ is constitutionally phosphorylated in 3T3 and HeLa cells. Plos Biology. DOI: 10.1371/Journal.Pbio.1002192.G007  0.318
2015 Zhang P, Knape MJ, Ahuja LG, Keshwani MM, King CC, Sastri M, Herberg FW, Taylor SS. Single turnover and pre-steady-state kinetics for RIIβ holoenzyme phosphorylation in the presence of Mg 2+ versus Ca 2+ . Plos Biology. DOI: 10.1371/Journal.Pbio.1002192.G003  0.301
2015 Zhang P, Knape MJ, Ahuja LG, Keshwani MM, King CC, Sastri M, Herberg FW, Taylor SS. Crystal structures of the RIIβ holoenzyme showing active site phosphorylation in the presence of calcium. Plos Biology. DOI: 10.1371/Journal.Pbio.1002192.G001  0.375
2014 Srivastava AK, McDonald LR, Cembran A, Kim J, Masterson LR, McClendon CL, Taylor SS, Veglia G. Synchronous opening and closing motions are essential for cAMP-dependent protein kinase A signaling. Structure (London, England : 1993). 22: 1735-43. PMID 25458836 DOI: 10.1016/J.Str.2014.09.010  0.504
2014 McClendon CL, Kornev AP, Gilson MK, Taylor SS. Dynamic architecture of a protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 111: E4623-31. PMID 25319261 DOI: 10.1073/Pnas.1418402111  0.491
2014 Boras BW, Kornev A, Taylor SS, McCulloch AD. Using Markov state models to develop a mechanistic understanding of protein kinase A regulatory subunit RIα activation in response to cAMP binding. The Journal of Biological Chemistry. 289: 30040-51. PMID 25202018 DOI: 10.1074/Jbc.M114.568907  0.49
2014 Blumenthal DK, Copps J, Smith-Nguyen EV, Zhang P, Heller WT, Taylor SS. The roles of the RIIβ linker and N-terminal cyclic nucleotide-binding domain in determining the unique structures of the type IIβ protein kinase A: a small angle x-ray and neutron scattering study. The Journal of Biological Chemistry. 289: 28505-12. PMID 25112875 DOI: 10.1074/Jbc.M114.584177  0.541
2014 Gerlits O, Das A, Keshwani MM, Taylor S, Waltman MJ, Langan P, Heller WT, Kovalevsky A. Metal-free cAMP-dependent protein kinase can catalyze phosphoryl transfer. Biochemistry. 53: 3179-86. PMID 24786636 DOI: 10.1021/Bi5000965  0.425
2014 Shaw AS, Kornev AP, Hu J, Ahuja LG, Taylor SS. Kinases and pseudokinases: lessons from RAF. Molecular and Cellular Biology. 34: 1538-46. PMID 24567368 DOI: 10.1128/Mcb.00057-14  0.509
2014 Akimoto M, Moleschi K, Boulton S, VanSchouwen B, Selvaratnam R, Taylor SS, Melacini G. Allosteric linkers in cAMP signalling. Biochemical Society Transactions. 42: 139-44. PMID 24450641 DOI: 10.1042/Bst20130257  0.496
2014 Bruystens JG, Wu J, Fortezzo A, Kornev AP, Blumenthal DK, Taylor SS. PKA RIα homodimer structure reveals an intermolecular interface with implications for cooperative cAMP binding and Carney complex disease. Structure (London, England : 1993). 22: 59-69. PMID 24316401 DOI: 10.1016/J.Str.2013.10.012  0.491
2014 Gerlits O, Das A, Tian J, Keshwani M, Taylor S, Waltman MJ, Langan P, Heller W, Kovalevsky A. Insights into the phosphoryl transfer catalyzed by cAMP-dependent protein kinase Acta Crystallographica Section a Foundations and Advances. 70: C449-C449. DOI: 10.1107/S2053273314095503  0.51
2014 Wilderman A, Guo Y, Taylor S, Insel P. cAMP/PKA-mediated regulation of amino acid metabolism in murine T-lymphoma cells (1095.16) The Faseb Journal. 28. DOI: 10.1096/Fasebj.28.1_Supplement.1095.16  0.379
2014 Boras B, Taylor S, McCulloch A. Direct PKA-PDE interactions lead to localized cAMP signaling domains in adult cardiomyocytes (1013.7) The Faseb Journal. 28. DOI: 10.1096/Fasebj.28.1_Supplement.1013.7  0.404
2014 Zhang P, Copps J, Blumenthal D, Taylor S. Assembly of Protein Kinase a RIIβ Macromolecular Complexes Biophysical Journal. 106: 464a. DOI: 10.1016/J.Bpj.2013.11.2629  0.506
2013 Meharena HS, Chang P, Keshwani MM, Oruganty K, Nene AK, Kannan N, Taylor SS, Kornev AP. Deciphering the structural basis of eukaryotic protein kinase regulation. Plos Biology. 11: e1001680. PMID 24143133 DOI: 10.1371/Journal.Pbio.1001680  0.546
2013 Guo Y, Darshi M, Ma Y, Perkins GA, Shen Z, Haushalter KJ, Saito R, Chen A, Lee YS, Patel HH, Briggs SP, Ellisman MH, Olefsky JM, Taylor SS. Quantitative proteomic and functional analysis of liver mitochondria from high fat diet (HFD) diabetic mice. Molecular & Cellular Proteomics : McP. 12: 3744-58. PMID 24030101 DOI: 10.1074/Mcp.M113.027441  0.482
2013 Bastidas AC, Pierce LC, Walker RC, Johnson DA, Taylor SS. Influence of N-myristylation and ligand binding on the flexibility of the catalytic subunit of protein kinase A. Biochemistry. 52: 6368-79. PMID 24003983 DOI: 10.1021/Bi400575K  0.827
2013 Hu J, Stites EC, Yu H, Germino EA, Meharena HS, Stork PJ, Kornev AP, Taylor SS, Shaw AS. Allosteric activation of functionally asymmetric RAF kinase dimers. Cell. 154: 1036-46. PMID 23993095 DOI: 10.1016/J.Cell.2013.07.046  0.475
2013 Brown SH, Cheng CY, Saldanha SA, Wu J, Cottam HB, Sankaran B, Taylor SS. Implementing fluorescence anisotropy screening and crystallographic analysis to define PKA isoform-selective activation by cAMP analogs. Acs Chemical Biology. 8: 2164-72. PMID 23978166 DOI: 10.1021/Cb400247T  0.683
2013 Akimoto M, Selvaratnam R, McNicholl ET, Verma G, Taylor SS, Melacini G. Signaling through dynamic linkers as revealed by PKA. Proceedings of the National Academy of Sciences of the United States of America. 110: 14231-6. PMID 23946424 DOI: 10.1073/Pnas.1312644110  0.454
2013 Taylor SS, Shaw A, Hu J, Meharena HS, Kornev A. Pseudokinases from a structural perspective. Biochemical Society Transactions. 41: 981-6. PMID 23863167 DOI: 10.1042/Bst20130120  0.566
2013 Yu FX, Zhang Y, Park HW, Jewell JL, Chen Q, Deng Y, Pan D, Taylor SS, Lai ZC, Guan KL. Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation. Genes & Development. 27: 1223-32. PMID 23752589 DOI: 10.1101/Gad.219402.113  0.466
2013 Gerlits O, Waltman MJ, Taylor S, Langan P, Kovalevsky A. Insights into the phosphoryl transfer catalyzed by cAMP-dependent protein kinase: An X-ray crystallographic study of complexes with various metals and peptide substrate SP20 Biochemistry. 52: 3721-3727. PMID 23672593 DOI: 10.1021/Bi400066A  0.458
2013 Taylor SS, Zhang P, Steichen JM, Keshwani MM, Kornev AP. PKA: lessons learned after twenty years. Biochimica Et Biophysica Acta. 1834: 1271-8. PMID 23535202 DOI: 10.1016/J.Bbapap.2013.03.007  0.812
2013 Bastidas AC, Deal MS, Steichen JM, Guo Y, Wu J, Taylor SS. Phosphoryl transfer by protein kinase A is captured in a crystal lattice. Journal of the American Chemical Society. 135: 4788-98. PMID 23458248 DOI: 10.1021/Ja312237Q  0.834
2013 Sastri M, Haushalter KJ, Panneerselvam M, Chang P, Fridolfsson H, Finley JC, Ng D, Schilling JM, Miyanohara A, Day ME, Hakozaki H, Petrosyan S, Koller A, King CC, Darshi M, ... ... Taylor SS, et al. A kinase interacting protein (AKIP1) is a key regulator of cardiac stress. Proceedings of the National Academy of Sciences of the United States of America. 110: E387-96. PMID 23319652 DOI: 10.1073/Pnas.1221670110  0.311
2012 Cembran A, Masterson LR, McClendon CL, Taylor SS, Gao J, Veglia G. Conformational equilibrium of N-myristoylated cAMP-dependent protein kinase A by molecular dynamics simulations. Biochemistry. 51: 10186-96. PMID 23205665 DOI: 10.1021/Bi301279F  0.492
2012 Burgers PP, Ma Y, Margarucci L, Mackey M, van der Heyden MA, Ellisman M, Scholten A, Taylor SS, Heck AJ. A small novel A-kinase anchoring protein (AKAP) that localizes specifically protein kinase A-regulatory subunit I (PKA-RI) to the plasma membrane. The Journal of Biological Chemistry. 287: 43789-97. PMID 23115245 DOI: 10.1074/Jbc.M112.395970  0.624
2012 Guo Y, Wilderman A, Zhang L, Taylor SS, Insel PA. Quantitative proteomics analysis of the cAMP/protein kinase A signaling pathway. Biochemistry. 51: 9323-32. PMID 23110364 DOI: 10.1021/Bi301282K  0.4
2012 Xu X, Keshwani M, Meyer K, Sarikas A, Taylor S, Pan ZQ. Identification of the degradation determinants of insulin receptor substrate 1 for signaling cullin-RING E3 ubiquitin ligase 7-mediated ubiquitination. The Journal of Biological Chemistry. 287: 40758-66. PMID 23045529 DOI: 10.1074/Jbc.M112.405209  0.442
2012 Darshi M, Trinh KN, Murphy AN, Taylor SS. Targeting and import mechanism of coiled-coil helix coiled-coil helix domain-containing protein 3 (ChChd3) into the mitochondrial intermembrane space. The Journal of Biological Chemistry. 287: 39480-91. PMID 23019327 DOI: 10.1074/Jbc.M112.387696  0.454
2012 Taylor SS, Ilouz R, Zhang P, Kornev AP. Assembly of allosteric macromolecular switches: lessons from PKA. Nature Reviews. Molecular Cell Biology. 13: 646-58. PMID 22992589 DOI: 10.1038/Nrm3432  0.558
2012 Taylor SS, Keshwani MM, Steichen JM, Kornev AP. Evolution of the eukaryotic protein kinases as dynamic molecular switches. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 367: 2517-28. PMID 22889904 DOI: 10.1098/Rstb.2012.0054  0.795
2012 Kükrer B, Barbu IM, Copps J, Hogan P, Taylor SS, van Duijn E, Heck AJ. Conformational isomers of calcineurin follow distinct dissociation pathways. Journal of the American Society For Mass Spectrometry. 23: 1534-43. PMID 22811075 DOI: 10.1007/S13361-012-0441-8  0.329
2012 Ilouz R, Bubis J, Wu J, Yim YY, Deal MS, Kornev AP, Ma Y, Blumenthal DK, Taylor SS. Localization and quaternary structure of the PKA RIβ holoenzyme. Proceedings of the National Academy of Sciences of the United States of America. 109: 12443-8. PMID 22797896 DOI: 10.1073/Pnas.1209538109  0.669
2012 Kovalevsky AY, Johnson H, Hanson BL, Waltman MJ, Fisher SZ, Taylor S, Langan P. Low- and room-temperature X-ray structures of protein kinase A ternary complexes shed new light on its activity. Acta Crystallographica. Section D, Biological Crystallography. 68: 854-60. PMID 22751671 DOI: 10.1107/S0907444912014886  0.465
2012 Haste NM, Talabani H, Doo A, Merckx A, Langsley G, Taylor SS. Exploring the Plasmodium falciparum cyclic-adenosine monophosphate (cAMP)-dependent protein kinase (PfPKA) as a therapeutic target. Microbes and Infection / Institut Pasteur. 14: 838-50. PMID 22626931 DOI: 10.1016/J.Micinf.2012.05.004  0.501
2012 Bastidas AC, Deal MS, Steichen JM, Keshwani MM, Guo Y, Taylor SS. Role of N-terminal myristylation in the structure and regulation of cAMP-dependent protein kinase. Journal of Molecular Biology. 422: 215-29. PMID 22617327 DOI: 10.1016/J.Jmb.2012.05.021  0.841
2012 Keshwani MM, Klammt C, von Daake S, Ma Y, Kornev AP, Choe S, Insel PA, Taylor SS. Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 109: E1221-9. PMID 22493239 DOI: 10.1073/Pnas.1202741109  0.543
2012 Steichen JM, Kuchinskas M, Keshwani MM, Yang J, Adams JA, Taylor SS. Structural basis for the regulation of protein kinase A by activation loop phosphorylation. The Journal of Biological Chemistry. 287: 14672-80. PMID 22334660 DOI: 10.1074/Jbc.M111.335091  0.802
2012 Zhang P, Smith-Nguyen EV, Keshwani MM, Deal MS, Kornev AP, Taylor SS. Structure and allostery of the PKA RIIβ tetrameric holoenzyme. Science (New York, N.Y.). 335: 712-6. PMID 22323819 DOI: 10.1126/Science.1213979  0.513
2012 Abrahamsen H, O'Neill AK, Kannan N, Kruse N, Taylor SS, Jennings PA, Newton AC. Peptidyl-prolyl isomerase Pin1 controls down-regulation of conventional protein kinase C isozymes. The Journal of Biological Chemistry. 287: 13262-78. PMID 22318721 DOI: 10.1074/Jbc.M112.349753  0.521
2012 Yang J, Wu J, Steichen JM, Kornev AP, Deal MS, Li S, Sankaran B, Woods VL, Taylor SS. A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold. Journal of Molecular Biology. 415: 666-79. PMID 22138346 DOI: 10.1016/J.Jmb.2011.11.035  0.791
2012 Ilouz R, Bubis J, Wu J, Yim Y, Kornev A, Blumenthal D, Taylor S. Crystal Structure of Full-Length PKA Rib: Insights Into Novel Isoform Specificity of Tetrameric Holoenzyme Assembly Hormone and Metabolic Research. 44. DOI: 10.1055/s-0032-1304229  0.535
2011 Means CK, Lygren B, Langeberg LK, Jain A, Dixon RE, Vega AL, Gold MG, Petrosyan S, Taylor SS, Murphy AN, Ha T, Santana LF, Tasken K, Scott JD. An entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. Proceedings of the National Academy of Sciences of the United States of America. 108: E1227-35. PMID 22084075 DOI: 10.1073/Pnas.1107182108  0.557
2011 Osborne BW, Wu J, McFarland CJ, Nickl CK, Sankaran B, Casteel DE, Woods VL, Kornev AP, Taylor SS, Dostmann WR. Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication. Structure (London, England : 1993). 19: 1317-27. PMID 21893290 DOI: 10.1016/J.Str.2011.06.012  0.51
2011 Keshwani MM, von Daake S, Newton AC, Harris TK, Taylor SS. Hydrophobic motif phosphorylation is not required for activation loop phosphorylation of p70 ribosomal protein S6 kinase 1 (S6K1). The Journal of Biological Chemistry. 286: 23552-8. PMID 21561857 DOI: 10.1074/Jbc.M111.258004  0.546
2011 King CC, Sastri M, Chang P, Pennypacker J, Taylor SS. The rate of NF-κB nuclear translocation is regulated by PKA and A kinase interacting protein 1. Plos One. 6: e18713. PMID 21556136 DOI: 10.1371/Journal.Pone.0018713  0.396
2011 Day ME, Gaietta GM, Sastri M, Koller A, Mackey MR, Scott JD, Perkins GA, Ellisman MH, Taylor SS. Isoform-specific targeting of PKA to multivesicular bodies. The Journal of Cell Biology. 193: 347-63. PMID 21502359 DOI: 10.1083/Jcb.201010034  0.646
2011 Masterson LR, Shi L, Metcalfe E, Gao J, Taylor SS, Veglia G. Dynamically committed, uncommitted, and quenched states encoded in protein kinase A revealed by NMR spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 108: 6969-74. PMID 21471451 DOI: 10.1073/Pnas.1102701108  0.452
2011 Hu J, Yu H, Kornev AP, Zhao J, Filbert EL, Taylor SS, Shaw AS. Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF. Proceedings of the National Academy of Sciences of the United States of America. 108: 6067-72. PMID 21441104 DOI: 10.1073/Pnas.1102554108  0.442
2011 Boettcher AJ, Wu J, Kim C, Yang J, Bruystens J, Cheung N, Pennypacker JK, Blumenthal DA, Kornev AP, Taylor SS. Realizing the allosteric potential of the tetrameric protein kinase A RIα holoenzyme. Structure (London, England : 1993). 19: 265-76. PMID 21300294 DOI: 10.1016/J.Str.2010.12.005  0.495
2011 McLaughlin WA, Hou T, Taylor SS, Wang W. The identification of novel cyclic AMP-dependent protein kinase anchoring proteins using bioinformatic filters and peptide arrays. Protein Engineering, Design & Selection : Peds. 24: 333-9. PMID 21115539 DOI: 10.1093/Protein/Gzq106  0.529
2011 Badireddy S, Yunfeng G, Ritchie M, Akamine P, Wu J, Kim CW, Taylor SS, Qingsong L, Swaminathan K, Anand GS. Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: conformational selection highlights a new concept in allosteric inhibitor design. Molecular & Cellular Proteomics : McP. 10: M110.004390. PMID 21081668 DOI: 10.1074/Mcp.M110.004390  0.822
2011 Darshi M, Mendiola VL, Mackey MR, Murphy AN, Koller A, Perkins GA, Ellisman MH, Taylor SS. ChChd3, an inner mitochondrial membrane protein, is essential for maintaining crista integrity and mitochondrial function. The Journal of Biological Chemistry. 286: 2918-32. PMID 21081504 DOI: 10.1074/Jbc.M110.171975  0.525
2011 Taylor SS, Kornev AP. Protein kinases: evolution of dynamic regulatory proteins. Trends in Biochemical Sciences. 36: 65-77. PMID 20971646 DOI: 10.1016/J.Tibs.2010.09.006  0.481
2011 Masterson LR, Cheng C, Yu T, Tonelli M, Kornev A, Taylor SS, Veglia G. Erratum: Corrigendum: Dynamics connect substrate recognition to catalysis in protein kinase A Nature Chemical Biology. 7: 319-319. DOI: 10.1038/Nchembio0511-319  0.654
2010 Rinaldi J, Wu J, Yang J, Ralston CY, Sankaran B, Moreno S, Taylor SS. Structure of yeast regulatory subunit: a glimpse into the evolution of PKA signaling. Structure (London, England : 1993). 18: 1471-82. PMID 21070946 DOI: 10.1016/J.Str.2010.08.013  0.488
2010 Masterson LR, Cheng C, Yu T, Tonelli M, Kornev A, Taylor SS, Veglia G. Dynamics connect substrate recognition to catalysis in protein kinase A. Nature Chemical Biology. 6: 821-8. PMID 20890288 DOI: 10.1038/Nchembio.452  0.647
2010 Patel HH, Hamuro LL, Chun BJ, Kawaraguchi Y, Quick A, Rebolledo B, Pennypacker J, Thurston J, Rodriguez-Pinto N, Self C, Olson G, Insel PA, Giles WR, Taylor SS, Roth DM. Disruption of protein kinase A localization using a trans-activator of transcription (TAT)-conjugated A-kinase-anchoring peptide reduces cardiac function. The Journal of Biological Chemistry. 285: 27632-40. PMID 20581396 DOI: 10.1074/Jbc.M110.146589  0.388
2010 Sjoberg TJ, Kornev AP, Taylor SS. Dissecting the cAMP-inducible allosteric switch in protein kinase A RIalpha. Protein Science : a Publication of the Protein Society. 19: 1213-21. PMID 20512974 DOI: 10.1002/Pro.400  0.831
2010 Gleick PH, Adams RM, Amasino RM, Anders E, Anderson DJ, Anderson WW, Anselin LE, Arroyo MK, Asfaw B, Ayala FJ, Bax A, Bebbington AJ, Bell G, Bennett MV, Bennetzen JL, ... ... Taylor SS, et al. Climate change and the integrity of science. Science (New York, N.Y.). 328: 689-90. PMID 20448167 DOI: 10.1126/Science.328.5979.689  0.421
2010 Taylor SS, Kornev AP. Yet another "active" pseudokinase, Erb3. Proceedings of the National Academy of Sciences of the United States of America. 107: 8047-8. PMID 20421461 DOI: 10.1073/Pnas.1003436107  0.529
2010 McNicholl ET, Das R, SilDas S, Taylor SS, Melacini G. Communication between tandem cAMP binding domains in the regulatory subunit of protein kinase A-Ialpha as revealed by domain-silencing mutations. The Journal of Biological Chemistry. 285: 15523-37. PMID 20202931 DOI: 10.1074/Jbc.M110.105783  0.522
2010 Anand GS, Krishnamurthy S, Bishnoi T, Kornev A, Taylor SS, Johnson DA. Cyclic AMP- and (Rp)-cAMPS-induced conformational changes in a complex of the catalytic and regulatory (RI{alpha}) subunits of cyclic AMP-dependent protein kinase. Molecular & Cellular Proteomics : McP. 9: 2225-37. PMID 20167947 DOI: 10.1074/Mcp.M900388-Mcp200  0.467
2010 Sarma GN, Kinderman FS, Kim C, von Daake S, Chen L, Wang BC, Taylor SS. Structure of D-AKAP2:PKA RI complex: insights into AKAP specificity and selectivity. Structure (London, England : 1993). 18: 155-66. PMID 20159461 DOI: 10.1016/J.Str.2009.12.012  0.818
2010 Steichen JM, Iyer GH, Li S, Saldanha SA, Deal MS, Woods VL, Taylor SS. Global consequences of activation loop phosphorylation on protein kinase A. The Journal of Biological Chemistry. 285: 3825-32. PMID 19965870 DOI: 10.1074/Jbc.M109.061820  0.811
2010 Kornev AP, Taylor SS. Defining the conserved internal architecture of a protein kinase. Biochimica Et Biophysica Acta. 1804: 440-4. PMID 19879387 DOI: 10.1016/J.Bbapap.2009.10.017  0.499
2010 Valiev M, Yang J, Adams JA, Taylor SS, Weare JH. Correction to “Phosphorylation Reaction in cAPK Protein Kinase-Free Energy Quantum Mechanical/Molecular Mechanics Simulations” Journal of Physical Chemistry B. 114: 6763-6763. DOI: 10.1021/Jp910239G  0.347
2010 Fajer M, Taylor S, McCammon JA. Dynamics of the PKA C-Subunit Major Conformational States Using REXAMD Biophysical Journal. 98: 444a. DOI: 10.1016/J.Bpj.2009.12.2410  0.46
2010 Johnson DA, Akamine P, Radzio-Andzelm E, Madhusudan M, Taylor SS. ChemInform Abstract: Dynamics of cAMP-Dependent Protein Kinase Cheminform. 32: no-no. DOI: 10.1002/CHIN.200140285  0.385
2009 Khavrutskii IV, Grant B, Taylor SS, McCammon JA. A transition path ensemble study reveals a linchpin role for Mg(2+) during rate-limiting ADP release from protein kinase A. Biochemistry. 48: 11532-45. PMID 19886670 DOI: 10.1021/Bi901475G  0.769
2009 Cheng CY, Yang J, Taylor SS, Blumenthal DK. Sensing domain dynamics in protein kinase A-I{alpha} complexes by solution X-ray scattering. The Journal of Biological Chemistry. 284: 35916-25. PMID 19837668 DOI: 10.1074/Jbc.M109.059493  0.659
2009 Eggers CT, Schafer JC, Goldenring JR, Taylor SS. D-AKAP2 interacts with Rab4 and Rab11 through its RGS domains and regulates transferrin receptor recycling. The Journal of Biological Chemistry. 284: 32869-80. PMID 19797056 DOI: 10.1074/Jbc.M109.022582  0.463
2009 Brown SH, Wu J, Kim C, Alberto K, Taylor SS. Novel isoform-specific interfaces revealed by PKA RIIbeta holoenzyme structures. Journal of Molecular Biology. 393: 1070-82. PMID 19748511 DOI: 10.1016/J.Jmb.2009.09.014  0.588
2009 Thompson EE, Kornev AP, Kannan N, Kim C, Ten Eyck LF, Taylor SS. Comparative surface geometry of the protein kinase family. Protein Science : a Publication of the Protein Society. 18: 2016-26. PMID 19610074 DOI: 10.1002/Pro.209  0.499
2009 Romano RA, Kannan N, Kornev AP, Allison CJ, Taylor SS. A chimeric mechanism for polyvalent trans-phosphorylation of PKA by PDK1. Protein Science : a Publication of the Protein Society. 18: 1486-97. PMID 19530248 DOI: 10.1002/Pro.146  0.508
2009 Kennedy EJ, Yang J, Pillus L, Taylor SS, Ghosh G. Identifying critical non-catalytic residues that modulate protein kinase A activity. Plos One. 4: e4746. PMID 19270744 DOI: 10.1371/Journal.Pone.0004746  0.517
2009 Kornev AP, Taylor SS. Pseudokinases: functional insights gleaned from structure. Structure (London, England : 1993). 17: 5-7. PMID 19141276 DOI: 10.1016/J.Str.2008.12.005  0.337
2009 Yang J, Kennedy EJ, Wu J, Deal MS, Pennypacker J, Ghosh G, Taylor SS. Contribution of non-catalytic core residues to activity and regulation in protein kinase A. The Journal of Biological Chemistry. 284: 6241-8. PMID 19122195 DOI: 10.1074/Jbc.M805862200  0.562
2009 Gould CM, Kannan N, Taylor SS, Newton AC. The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail. The Journal of Biological Chemistry. 284: 4921-35. PMID 19091746 DOI: 10.1074/Jbc.M808436200  0.559
2009 Boettcher AJ, Wu J, Kim C, Yang J, Bruystens J, Cheung N, Pennypacker JK, Blumenthal DA, Kornev AP, Taylor SS. Crystal structure of (73-244)RIa:C holoenzyme of cAMP-dependent Protein kinase Structure. 19: 265-276. DOI: 10.2210/Pdb3Pvb/Pdb  0.492
2009 Kornev AP, Taylor SS, Ten Eyck LF. Correction: A Generalized Allosteric Mechanism for cis-Regulated Cyclic Nucleotide Binding Domains Plos Computational Biology. 5. DOI: 10.1371/Annotation/43Fd4Ca3-0996-462C-Ad89-395C369Cbaa2  0.32
2009 Casteel DE, Smith-Nguyen EV, Sankaran B, Spraggon G, Hampton EN, Pilz RB, Taylor SS, Kim C. The first crystal structure of cyclic GMP-dependent protein kinase Iβ dimerization/docking domain reveals molecular details of isoform-specific anchoring Bmc Pharmacology. 9: P6. DOI: 10.1186/1471-2210-9-S1-P6  0.527
2008 Kornev AP, Taylor SS, Ten Eyck LF. A helix scaffold for the assembly of active protein kinases. Proceedings of the National Academy of Sciences of the United States of America. 105: 14377-82. PMID 18787129 DOI: 10.1073/Pnas.0807988105  0.509
2008 Torkamani A, Kannan N, Taylor SS, Schork NJ. Congenital disease SNPs target lineage specific structural elements in protein kinases. Proceedings of the National Academy of Sciences of the United States of America. 105: 9011-6. PMID 18579784 DOI: 10.1073/Pnas.0802403105  0.417
2008 Kannan N, Taylor SS. Rethinking pseudokinases. Cell. 133: 204-5. PMID 18423189 DOI: 10.1016/j.cell.2008.04.005  0.338
2008 Kornev AP, Taylor SS, Ten Eyck LF. A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains. Plos Computational Biology. 4: e1000056. PMID 18404204 DOI: 10.1371/Journal.Pcbi.1000056  0.466
2008 Masterson LR, Mascioni A, Traaseth NJ, Taylor SS, Veglia G. Allosteric cooperativity in protein kinase A. Proceedings of the National Academy of Sciences of the United States of America. 105: 506-11. PMID 18178622 DOI: 10.1073/Pnas.0709214104  0.535
2008 Ten Eyck LF, Taylor SS, Kornev AP. Conserved spatial patterns across the protein kinase family. Biochimica Et Biophysica Acta. 1784: 238-43. PMID 18067871 DOI: 10.1016/J.Bbapap.2007.11.002  0.521
2008 Taylor SS, Kim C, Cheng CY, Brown SH, Wu J, Kannan N. Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design. Biochimica Et Biophysica Acta. 1784: 16-26. PMID 17996741 DOI: 10.1016/J.Bbapap.2007.10.002  0.736
2008 Kannan N, Neuwald AF, Taylor SS. Analogous regulatory sites within the alphaC-beta4 loop regions of ZAP-70 tyrosine kinase and AGC kinases. Biochimica Et Biophysica Acta. 1784: 27-32. PMID 17977811 DOI: 10.1016/J.Bbapap.2007.09.007  0.518
2007 Kannan N, Wu J, Anand GS, Yooseph S, Neuwald AF, Venter JC, Taylor SS. Evolution of allostery in the cyclic nucleotide binding module. Genome Biology. 8: R264. PMID 18076763 DOI: 10.1186/Gb-2007-8-12-R264  0.627
2007 Valiev M, Yang J, Adams JA, Taylor SS, Weare JH. Phosphorylation reaction in cAPK protein kinase-free energy quantum mechanical/molecular mechanics simulations. The Journal of Physical Chemistry. B. 111: 13455-64. PMID 17983217 DOI: 10.1021/Jp074853Q  0.393
2007 Anand GS, Hotchko M, Brown SH, Ten Eyck LF, Komives EA, Taylor SS. R-subunit isoform specificity in protein kinase A: distinct features of protein interfaces in PKA types I and II by amide H/2H exchange mass spectrometry. Journal of Molecular Biology. 374: 487-99. PMID 17942118 DOI: 10.1016/J.Jmb.2007.09.035  0.511
2007 Wu J, Brown SH, von Daake S, Taylor SS. PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity. Science (New York, N.Y.). 318: 274-9. PMID 17932298 DOI: 10.1126/Science.1146447  0.565
2007 Alto NM, Weflen AW, Rardin MJ, Yarar D, Lazar CS, Tonikian R, Koller A, Taylor SS, Boone C, Sidhu SS, Schmid SL, Hecht GA, Dixon JE. The type III effector EspF coordinates membrane trafficking by the spatiotemporal activation of two eukaryotic signaling pathways. The Journal of Cell Biology. 178: 1265-78. PMID 17893247 DOI: 10.1083/Jcb.200705021  0.538
2007 Kim C, Cheng CY, Saldanha SA, Taylor SS. PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. Cell. 130: 1032-43. PMID 17889648 DOI: 10.1016/J.Cell.2007.07.018  0.714
2007 Martin BR, Deerinck TJ, Ellisman MH, Taylor SS, Tsien RY. Isoform-specific PKA dynamics revealed by dye-triggered aggregation and DAKAP1alpha-mediated localization in living cells. Chemistry & Biology. 14: 1031-42. PMID 17884635 DOI: 10.1016/J.Chembiol.2007.07.017  0.563
2007 Anand G, Taylor SS, Johnson DA. Cyclic-AMP and pseudosubstrate effects on type-I A-kinase regulatory and catalytic subunit binding kinetics. Biochemistry. 46: 9283-91. PMID 17658893 DOI: 10.1021/Bi700421H  0.536
2007 Humphries KM, Pennypacker JK, Taylor SS. Redox regulation of cAMP-dependent protein kinase signaling: kinase versus phosphatase inactivation. The Journal of Biological Chemistry. 282: 22072-9. PMID 17548350 DOI: 10.1074/Jbc.M702582200  0.4
2007 Navarro L, Koller A, Nordfelth R, Wolf-Watz H, Taylor S, Dixon JE. Identification of a molecular target for the Yersinia protein kinase A. Molecular Cell. 26: 465-77. PMID 17531806 DOI: 10.1016/J.Molcel.2007.04.025  0.662
2007 Lim CJ, Han J, Yousefi N, Ma Y, Amieux PS, McKnight GS, Taylor SS, Ginsberg MH. Alpha4 integrins are type I cAMP-dependent protein kinase-anchoring proteins. Nature Cell Biology. 9: 415-21. PMID 17369818 DOI: 10.1038/Ncb1561  0.519
2007 Kannan N, Taylor SS, Zhai Y, Venter JC, Manning G. Structural and functional diversity of the microbial kinome. Plos Biology. 5: e17. PMID 17355172 DOI: 10.1371/Journal.Pbio.0050017  0.645
2007 Yooseph S, Sutton G, Rusch DB, Halpern AL, Williamson SJ, Remington K, Eisen JA, Heidelberg KB, Manning G, Li W, Jaroszewski L, Cieplak P, Miller CS, Li H, Mashiyama ST, ... ... Taylor SS, et al. The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. Plos Biology. 5: e16. PMID 17355171 DOI: 10.1371/Journal.Pbio.0050016  0.659
2007 Schauble S, King CC, Darshi M, Koller A, Shah K, Taylor SS. Identification of ChChd3 as a novel substrate of the cAMP-dependent protein kinase (PKA) using an analog-sensitive catalytic subunit. The Journal of Biological Chemistry. 282: 14952-9. PMID 17242405 DOI: 10.1074/Jbc.M609221200  0.835
2007 Kannan N, Haste N, Taylor SS, Neuwald AF. The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module. Proceedings of the National Academy of Sciences of the United States of America. 104: 1272-7. PMID 17227859 DOI: 10.1073/Pnas.0610251104  0.488
2007 Das R, Esposito V, Abu-Abed M, Anand GS, Taylor SS, Melacini G. cAMP activation of PKA defines an ancient signaling mechanism Proceedings of the National Academy of Sciences of the United States of America. 104: 93-98. PMID 17182741 DOI: 10.1073/Pnas.0609033103  0.501
2006 Saldanha SA, Kaler G, Cottam HB, Abagyan R, Taylor SS. Assay principle for modulators of protein-protein interactions and its application to non-ATP-competitive ligands targeting protein kinase A. Analytical Chemistry. 78: 8265-72. PMID 17165815 DOI: 10.1021/Ac061104G  0.456
2006 Kornev AP, Haste NM, Taylor SS, Eyck LF. Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism. Proceedings of the National Academy of Sciences of the United States of America. 103: 17783-8. PMID 17095602 DOI: 10.1073/Pnas.0607656103  0.502
2006 Kinderman FS, Kim C, von Daake S, Ma Y, Pham BQ, Spraggon G, Xuong NH, Jennings PA, Taylor SS. A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Molecular Cell. 24: 397-408. PMID 17081990 DOI: 10.1016/J.Molcel.2006.09.015  0.839
2006 Cranston AN, Carniti C, Oakhill K, Radzio-Andzelm E, Stone EA, McCallion AS, Hodgson S, Clarke S, Mondellini P, Leyland J, Pierotti MA, Whittaker J, Taylor SS, Bongarzone I, Ponder BA. RET is constitutively activated by novel tandem mutations that alter the active site resulting in multiple endocrine neoplasia type 2B. Cancer Research. 66: 10179-87. PMID 17047083 DOI: 10.1158/0008-5472.Can-06-0884  0.392
2006 Esposito V, Sjoberg T, Das R, Brown S, Taylor SS, Melacini G. NMR assignment of the cAMP-binding domain A of the PKA regulatory subunit [62] Journal of Biomolecular Nmr. 36: 64. PMID 17016670 DOI: 10.1007/S10858-006-9050-9  0.818
2006 Kim C, Vigil D, Anand G, Taylor SS. Structure and dynamics of PKA signaling proteins. European Journal of Cell Biology. 85: 651-4. PMID 16647784 DOI: 10.1016/J.Ejcb.2006.02.004  0.683
2006 Vigil D, Blumenthal DK, Taylor SS, Trewhella J. Solution scattering reveals large differences in the global structures of type II protein kinase A isoforms. Journal of Molecular Biology. 357: 880-9. PMID 16460759 DOI: 10.1016/J.Jmb.2006.01.006  0.737
2006 Niedner RH, Buzko OV, Haste NM, Taylor A, Gribskov M, Taylor SS. Protein kinase resource: an integrated environment for phosphorylation research. Proteins. 63: 78-86. PMID 16435372 DOI: 10.1002/Prot.20825  0.446
2006 Gullingsrud J, Kim C, Taylor SS, McCammon JA. Dynamic binding of PKA regulatory subunit RIα Structure. 14: 141-149. PMID 16407073 DOI: 10.1016/J.Str.2005.09.019  0.489
2006 Vigil D, Lin JH, Sotriffer CA, Pennypacker JK, McCammon JA, Taylor SS. A simple electrostatic switch important in the activation of type I protein kinase A by cyclic AMP. Protein Science : a Publication of the Protein Society. 15: 113-21. PMID 16322564 DOI: 10.1110/Ps.051723606  0.783
2006 Taylor SS, Ghosh G. Protein kinases: Catalysis and regulation Current Opinion in Structural Biology. 16: 665-667. DOI: 10.1016/J.Sbi.2006.11.001  0.498
2005 Burns-Hamuro LL, Hamuro Y, Kim JS, Sigala P, Fayos R, Stranz DD, Jennings PA, Taylor SS, Woods VL. Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange. Protein Science : a Publication of the Protein Society. 14: 2982-92. PMID 16260760 DOI: 10.1110/Ps.051687305  0.47
2005 Wu J, Yang J, Kannan N, Madhusudan, Xuong NH, Ten Eyck LF, Taylor SS. Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix. Protein Science : a Publication of the Protein Society. 14: 2871-9. PMID 16253959 DOI: 10.1110/Ps.051715205  0.702
2005 Taylor SS, Kim C, Vigil D, Haste NM, Yang J, Wu J, Anand GS. Dynamics of signaling by PKA. Biochimica Et Biophysica Acta. 1754: 25-37. PMID 16214430 DOI: 10.1016/J.Bbapap.2005.08.024  0.787
2005 Taylor SS, Haste NM, Ghosh G. PKR and eIF2alpha: integration of kinase dimerization, activation, and substrate docking. Cell. 122: 823-5. PMID 16179248 DOI: 10.1016/J.Cell.2005.09.007  0.505
2005 Zhang J, Hupfeld CJ, Taylor SS, Olefsky JM, Tsien RY. Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature. 437: 569-73. PMID 16177793 DOI: 10.1038/Nature04140  0.39
2005 Vigil D, Blumenthal DK, Taylor SS, Trewhella J. The conformationally dynamic C helix of the RIalpha subunit of protein kinase A mediates isoform-specific domain reorganization upon C subunit binding. The Journal of Biological Chemistry. 280: 35521-7. PMID 16109722 DOI: 10.1074/Jbc.M506769200  0.757
2005 Iyer GH, Garrod S, Woods VL, Taylor SS. Catalytic independent functions of a protein kinase as revealed by a kinase-dead mutant: study of the Lys72His mutant of cAMP-dependent kinase. Journal of Molecular Biology. 351: 1110-22. PMID 16054648 DOI: 10.1016/J.Jmb.2005.06.011  0.574
2005 Kim C, Xuong NH, Taylor SS. Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA. Science (New York, N.Y.). 307: 690-6. PMID 15692043 DOI: 10.1126/Science.1104607  0.726
2005 Yang J, Garrod SM, Deal MS, Anand GS, Woods VL, Taylor S. Allosteric network of cAMP-dependent protein kinase revealed by mutation of Tyr204 in the P+1 loop. Journal of Molecular Biology. 346: 191-201. PMID 15663937 DOI: 10.1016/J.Jmb.2004.11.030  0.517
2005 Sastri M, Barraclough DM, Carmichael PT, Taylor SS. A-kinase-interacting protein localizes protein kinase A in the nucleus. Proceedings of the National Academy of Sciences of the United States of America. 102: 349-54. PMID 15630084 DOI: 10.1073/Pnas.0408608102  0.709
2005 Berman HM, Ten Eyck LF, Goodsell DS, Haste NM, Kornev A, Taylor SS. The cAMP binding domain: An ancient signaling module Proceedings of the National Academy of Sciences of the United States of America. 102: 45-50. PMID 15618393 DOI: 10.1073/Pnas.0408579102  0.486
2005 Iyer GH, Moore MJ, Taylor SS. Consequences of lysine 72 mutation on the phosphorylation and activation state of cAMP-dependent kinase. The Journal of Biological Chemistry. 280: 8800-7. PMID 15618230 DOI: 10.1074/Jbc.M407586200  0.556
2005 Humphries KM, Deal MS, Taylor SS. Enhanced dephosphorylation of cAMP-dependent protein kinase by oxidation and thiol modification. The Journal of Biological Chemistry. 280: 2750-8. PMID 15533936 DOI: 10.1074/Jbc.M410242200  0.533
2005 Zheng J, Trafny EA, Knighton DR, Xuong NH, Taylor SS, Ten Eyck LF, Sowadski JM. 2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor. Acta Crystallographica. Section D, Biological Crystallography. 49: 362-5. PMID 15299527 DOI: 10.1107/S0907444993000423  0.46
2005 Knighton DR, Bell SM, Zheng J, Ten Eyck LF, Xuong NH, Taylor SS, Sowadski JM. 2.0 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with a peptide inhibitor and detergent. Acta Crystallographica. Section D, Biological Crystallography. 49: 357-61. PMID 15299526 DOI: 10.1107/S0907444993000502  0.549
2005 Karlsson R, Zheng J, Xuong N, Taylor SS, Sowadski JM. Structure of the mammalian catalytic subunit of cAMP-dependent protein kinase and an inhibitor peptide displays an open conformation. Acta Crystallographica. Section D, Biological Crystallography. 49: 381-8. PMID 15299513 DOI: 10.1107/S0907444993002306  0.629
2004 Burns-Hamuro LL, Barraclough DM, Taylor SS. Identification and functional analysis of dual-specific A kinase-anchoring protein-2. Methods in Enzymology. 390: 354-374. PMID 15488188 DOI: 10.1016/S0076-6879(04)90022-5  0.478
2004 Nolen B, Taylor S, Ghosh G. Regulation of protein kinases; controlling activity through activation segment conformation. Molecular Cell. 15: 661-75. PMID 15350212 DOI: 10.1016/J.Molcel.2004.08.024  0.463
2004 Wu J, Brown S, Xuong NH, Taylor SS. RIalpha subunit of PKA: a cAMP-free structure reveals a hydrophobic capping mechanism for docking cAMP into site B. Structure (London, England : 1993). 12: 1057-65. PMID 15274925 DOI: 10.1016/J.Str.2004.03.022  0.696
2004 Hamuro Y, Anand GS, Kim JS, Juliano C, Stranz DD, Taylor SS, Woods VL. Mapping intersubunit interactions of the regulatory subunit (RIalpha) in the type I holoenzyme of protein kinase A by amide hydrogen/deuterium exchange mass spectrometry (DXMS). Journal of Molecular Biology. 340: 1185-96. PMID 15236976 DOI: 10.1016/J.Jmb.2004.05.042  0.506
2004 Wu J, Jones JM, Nguyen-Huu X, Ten Eyck LF, Taylor SS. Crystal structures of RIalpha subunit of cyclic adenosine 5'-monophosphate (cAMP)-dependent protein kinase complexed with (Rp)-adenosine 3',5'-cyclic monophosphothioate and (Sp)-adenosine 3',5'-cyclic monophosphothioate, the phosphothioate analogues of cAMP. Biochemistry. 43: 6620-9. PMID 15157095 DOI: 10.1021/Bi0302503  0.523
2004 Vigil D, Blumenthal DK, Brown S, Taylor SS, Trewhella J. Differential effects of substrate on type I and type II PKA holoenzyme dissociation. Biochemistry. 43: 5629-36. PMID 15134437 DOI: 10.1021/Bi0499157  0.72
2004 Vigil D, Blumenthal DK, Heller WT, Brown S, Canaves JM, Taylor SS, Trewhella J. Conformational differences among solution structures of the type Ialpha, IIalpha and IIbeta protein kinase A regulatory subunit homodimers: role of the linker regions. Journal of Molecular Biology. 337: 1183-94. PMID 15046986 DOI: 10.1016/J.Jmb.2004.02.028  0.764
2004 Taylor SS, Yang J, Wu J, Haste NM, Radzio-Andzelm E, Anand G. PKA: a portrait of protein kinase dynamics. Biochimica Et Biophysica Acta. 1697: 259-69. PMID 15023366 DOI: 10.1016/J.Bbapap.2003.11.029  0.567
2004 Heller WT, Vigil D, Brown S, Blumenthal DK, Taylor SS, Trewhella J. C subunits binding to the protein kinase A RI alpha dimer induce a large conformational change. The Journal of Biological Chemistry. 279: 19084-90. PMID 14985329 DOI: 10.1074/Jbc.M313405200  0.71
2004 Yang J, Ten Eyck LF, Xuong NH, Taylor SS. Crystal structure of a cAMP-dependent protein kinase mutant at 1.26A: new insights into the catalytic mechanism. Journal of Molecular Biology. 336: 473-87. PMID 14757059 DOI: 10.1016/J.Jmb.2003.11.044  0.721
2004 Akamine P, Madhusudan, Brunton LL, Ou HD, Canaves JM, Xuong NH, Taylor SS. Balanol analogues probe specificity determinants and the conformational malleability of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase catalytic subunit. Biochemistry. 43: 85-96. PMID 14705934 DOI: 10.1021/Bi035042P  0.863
2004 Zawadzki KM, Taylor SS. cAMP-dependent protein kinase regulatory subunit type IIbeta: active site mutations define an isoform-specific network for allosteric signaling by cAMP. The Journal of Biological Chemistry. 279: 7029-36. PMID 14625280 DOI: 10.1074/Jbc.M310804200  0.852
2003 Anand GS, Law D, Mandell JG, Snead AN, Tsigelny I, Taylor SS, Ten Eyck LF, Komives EA. Identification of the protein kinase A regulatory RIalpha-catalytic subunit interface by amide H/2H exchange and protein docking. Proceedings of the National Academy of Sciences of the United States of America. 100: 13264-9. PMID 14583592 DOI: 10.1073/Pnas.2232255100  0.465
2003 Gisler SM, Madjdpour C, Bacic D, Pribanic S, Taylor SS, Biber J, Murer H. PDZK1: II. an anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells. Kidney International. 64: 1746-54. PMID 14531807 DOI: 10.1046/J.1523-1755.2003.00267.X  0.398
2003 Zawadzki KM, Hamuro Y, Kim JS, Garrod S, Stranz DD, Taylor SS, Woods VL. Dissecting interdomain communication within cAPK regulatory subunit type IIβ using enhanced amide hydrogen/deuterium exchange mass spectrometry (DXMS) Protein Science. 12: 1980-1990. PMID 12930997 DOI: 10.1110/Ps.03166903  0.836
2003 Banky P, Roy M, Newlon MG, Morikis D, Haste NM, Taylor SS, Jennings PA. Related protein-protein interaction modules present drastically different surface topographies despite a conserved helical platform. Journal of Molecular Biology. 330: 1117-29. PMID 12860132 DOI: 10.1016/S0022-2836(03)00552-7  0.811
2003 Zawadzki KM, Pan CP, Barkley MD, Johnson D, Taylor SS. Endogenous tryptophan residues of cAPK regulatory subunit type IIbeta reveal local variations in environments and dynamics. Proteins. 51: 552-61. PMID 12784214 DOI: 10.1002/Prot.10326  0.84
2003 Burns LL, Canaves JM, Pennypacker JK, Blumenthal DK, Taylor SS. Isoform specific differences in binding of a dual-specificity A-kinase anchoring protein to type I and type II regulatory subunits of PKA. Biochemistry. 42: 5754-63. PMID 12741833 DOI: 10.1021/Bi0265729  0.502
2003 Hamuro Y, Zawadzki KM, Kim JS, Stranz DD, Taylor SS, Woods VL. Dynamics of cAPK type IIbeta activation revealed by enhanced amide H/2H exchange mass spectrometry (DXMS). Journal of Molecular Biology. 327: 1065-76. PMID 12662931 DOI: 10.1016/S0022-2836(03)00234-1  0.848
2003 Kammerer S, Burns-Hamuro LL, Ma Y, Hamon SC, Canaves JM, Shi MM, Nelson MR, Sing CF, Cantor CR, Taylor SS, Braun A. Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: a disease susceptibility polymorphism. Proceedings of the National Academy of Sciences of the United States of America. 100: 4066-71. PMID 12646697 DOI: 10.1073/Pnas.2628028100  0.393
2003 Burns-Hamuro LL, Ma Y, Kammerer S, Reineke U, Self C, Cook C, Olson GL, Cantor CR, Braun A, Taylor SS. Designing isoform-specific peptide disruptors of protein kinase A localization. Proceedings of the National Academy of Sciences of the United States of America. 100: 4072-7. PMID 12646696 DOI: 10.1073/Pnas.2628038100  0.436
2003 Akamine P, Madhusudan, Wu J, Xuong NH, Ten Eyck LF, Taylor SS. Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure. Journal of Molecular Biology. 327: 159-71. PMID 12614615 DOI: 10.1016/S0022-2836(02)01446-8  0.848
2003 Moore MJ, Adams JA, Taylor SS. Structural basis for peptide binding in protein kinase A. Role of glutamic acid 203 and tyrosine 204 in the peptide-positioning loop. The Journal of Biological Chemistry. 278: 10613-8. PMID 12499371 DOI: 10.1074/Jbc.M210807200  0.422
2002 Taylor SS, Kim CW, Cheng CY, Kannan N, Sastri M, Eggers CW, Wu J. Fifty Years Since the Discovery of PKA. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 4123. PMID 29430987 DOI: 10.1096/Fasebj.22.1_Supplement.412.3  0.711
2002 Chatterji A, Burns LL, Taylor SS, Lomonossoff GP, Johnson JE, Lin T, Porta C. Cowpea mosaic virus: From the presentation of antigenic peptides to the display of active biomaterials Intervirology. 45: 362-370. PMID 12602357 DOI: 10.1159/000067929  0.301
2002 Anand GS, Hughes CA, Jones JM, Taylor SS, Komives EA. Amide H/2H exchange reveals communication between the cAMP and catalytic subunit-binding sites in the R(I)alpha subunit of protein kinase A. Journal of Molecular Biology. 323: 377-86. PMID 12381327 DOI: 10.1016/S0022-2836(02)00919-1  0.475
2002 Moore MJ, Kanter JR, Jones KC, Taylor SS. Phosphorylation of the catalytic subunit of protein kinase A. Autophosphorylation versus phosphorylation by phosphoinositide-dependent kinase-1. The Journal of Biological Chemistry. 277: 47878-84. PMID 12372837 DOI: 10.1074/Jbc.M204970200  0.548
2002 Kuhn P, Lesley SA, Mathews II, Canaves JM, Brinen LS, Dai X, Deacon AM, Elsliger MA, Eshaghi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, Guda C, Hodgson KO, ... ... Taylor SS, et al. Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 A resolution. Proteins. 49: 142-5. PMID 12211025 DOI: 10.1002/Prot.10202  0.359
2002 Hamuro Y, Burns LL, Canaves JM, Hoffman RC, Taylor SS, Woods VL. Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS) Journal of Molecular Biology. 321: 703-714. PMID 12206784 DOI: 10.1016/S0022-2836(02)00419-9  0.486
2002 Lesley SA, Kuhn P, Godzik A, Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, ... ... Taylor SS, et al. Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proceedings of the National Academy of Sciences of the United States of America. 99: 11664-9. PMID 12193646 DOI: 10.1073/Pnas.142413399  0.312
2002 Humphries KM, Juliano C, Taylor SS. Regulation of cAMP-dependent protein kinase activity by glutathionylation. The Journal of Biological Chemistry. 277: 43505-11. PMID 12189155 DOI: 10.1074/Jbc.M207088200  0.475
2002 Ma Y, Taylor S. A 15-residue bifunctional element in D-AKAP1 is required for both endoplasmic reticulum and mitochondrial targeting. The Journal of Biological Chemistry. 277: 27328-36. PMID 11994283 DOI: 10.1074/Jbc.M201421200  0.338
2002 Madhusudan, Akamine P, Xuong NH, Taylor SS. Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase. Nature Structural Biology. 9: 273-7. PMID 11896404 DOI: 10.1038/Nsb780  0.84
2002 Li F, Gangal M, Juliano C, Gorfain E, Taylor SS, Johnson DA. Evidence for an internal entropy contribution to phosphoryl transfer: A study of domain closure, backbone flexibility, and the catalytic cycle of cAMP-dependent protein kinase Journal of Molecular Biology. 315: 459-469. PMID 11786025 DOI: 10.1006/Jmbi.2001.5256  0.543
2002 Johnson DA, Akamine P, Radzio-Andzelm E, Madhusudan M, Taylor SS. Dynamics of cAMP-dependent protein kinase. Chemical Reviews. 101: 2243-70. PMID 11749372 DOI: 10.1021/Cr000226K  0.811
2002 Canaves JM, Taylor SS. Classification and phylogenetic analysis of the cAMP-dependent protein kinase regulatory subunit family Journal of Molecular Evolution. 54: 17-29. PMID 11734894 DOI: 10.1007/S00239-001-0013-1  0.416
2001 Zhang J, Ma Y, Taylor SS, Tsien RY. Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering. Proceedings of the National Academy of Sciences of the United States of America. 98: 14997-5002. PMID 11752448 DOI: 10.1073/Pnas.211566798  0.502
2001 Perkins GA, Wang L, Huang LJ, Humphries K, Yao VJ, Martone M, Deerinck TJ, Barraclough DM, Violin JD, Smith D, Newton A, Scott JD, Taylor SS, Ellisman MH. PKA, PKC, and AKAP localization in and around the neuromuscular junction. Bmc Neuroscience. 2: 17. PMID 11716788 DOI: 10.1186/1471-2202-2-17  0.567
2001 Diller TC, Madhusudan, Xuong NH, Taylor SS. Molecular basis for regulatory subunit diversity in cAMP-dependent protein kinase: crystal structure of the type II beta regulatory subunit. Structure (London, England : 1993). 9: 73-82. PMID 11342137 DOI: 10.1016/S0969-2126(00)00556-6  0.858
2001 Wong CF, Hünenberger PH, Akamine P, Narayana N, Diller T, McCammon JA, Taylor S, Xuong NH. Computational analysis of PKA-balanol interactions Journal of Medicinal Chemistry. 44: 1530-1539. PMID 11334563 DOI: 10.1021/Jm000443D  0.83
2001 Wang L, Sunahara RK, Krumins A, Perkins G, Crochiere ML, Mackey M, Bell S, Ellisman MH, Taylor SS. Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein. Proceedings of the National Academy of Sciences of the United States of America. 98: 3220-5. PMID 11248059 DOI: 10.1073/Pnas.051633398  0.594
2001 Herrgård S, Jambeck P, Taylor SS, Subramaniam S. Domain architecture of a Caenorhabditis elegans AKAP suggests a novel AKAP function. Febs Letters. 486: 107-11. PMID 11113448 DOI: 10.1016/S0014-5793(00)02201-8  0.476
2001 Li F, Gangal M, Jones JM, Deich J, Lovett KE, Taylor SS, Johnson DA. Consequences of cAMP and catalytic-subunit binding on the flexibility of the A-kinase regulatory subunit. Biochemistry. 39: 15626-32. PMID 11112551 DOI: 10.1021/Bi002196L  0.538
2001 Cheng X, Phelps C, Taylor SS. Differential Binding of cAMP-dependent Protein Kinase Regulatory Subunit Isoforms Iα and IIβ to the Catalytic Subunit Journal of Biological Chemistry. 276: 4102-4108. PMID 11110787 DOI: 10.1074/Jbc.M006447200  0.519
2000 Cànaves JM, Leon DA, Taylor SS. Consequences of cAMP-binding site mutations on the structural stability of the type I regulatory subunit of cAMP-dependent protein kinase. Biochemistry. 39: 15022-31. PMID 11106480 DOI: 10.1021/Bi001563Q  0.484
2000 Diller TC, Xuong NH, Taylor SS. Type II beta regulatory subunit of cAMP-dependent protein kinase: purification strategies to optimize crystallization. Protein Expression and Purification. 20: 357-64. PMID 11087674 DOI: 10.1006/Prep.2000.1312  0.815
2000 Banky P, Newlon MG, Roy M, Garrod S, Taylor SS, Jennings PA. Isoform-specific differences between the type Iα and IIα cyclic AMP-dependent protein kinase anchoring domains revealed by solution NMR Journal of Biological Chemistry. 275: 35146-35152. PMID 10899163 DOI: 10.1074/Jbc.M003961200  0.823
2000 Aimes RT, Hemmer W, Taylor SS. Serine-53 at the tip of the glycine-rich loop of cAMP-dependent protein kinase: Role in catalysis, P-site specificity, and interaction with inhibitors Biochemistry. 39: 8325-8332. PMID 10889042 DOI: 10.1021/Bi992800W  0.522
2000 Leon DA, Canaves JM, Taylor SS. Probing the multidomain structure of the type I regulatory subunit of cAMP-dependent protein kinase using mutational analysis: Role and environment of endogenous tryptophans Biochemistry. 39: 5662-5671. PMID 10801316 DOI: 10.1021/Bi992819Z  0.531
2000 Zaccolo M, De Giorgi F, Cho CY, Feng L, Knapp T, Negulescu PA, Taylor SS, Tsien RY, Pozzan T. A genetically encoded, fluorescent indicator for cyclic AMP in living cells. Nature Cell Biology. 2: 25-9. PMID 10620803 DOI: 10.1038/71345  0.368
1999 Gangal M, Clifford T, Deich J, Cheng X, Taylor SS, Johnson DA. Mobilization of the A-kinase N-myristate through an isoform-specific intermolecular switch. Proceedings of the National Academy of Sciences of the United States of America. 96: 12394-9. PMID 10535933 DOI: 10.1073/Pnas.96.22.12394  0.423
1999 Tsigelny I, Greenberg JP, Cox S, Nichols WL, Taylor SS, Ten Eyck LF. 600 ps molecular dynamics reveals stable substructures and flexible hinge points in cAMP dependent protein kinase. Biopolymers. 50: 513-24. PMID 10479734 DOI: 10.1002/(Sici)1097-0282(19991015)50:5<513::Aid-Bip5>3.0.Co;2-I  0.451
1999 Taylor SS, Radzio-Andzelm E, Cheng X, Ten Eyck L, Narayana N. Catalytic subunit of cyclic AMP-dependent protein kinase: structure and dynamics of the active site cleft. Pharmacology & Therapeutics. 82: 133-41. PMID 10454192 DOI: 10.1016/S0163-7258(99)00007-8  0.536
1999 Setyawan J, Koide K, Diller TC, Bunnage ME, Taylor SS, Nicolaou KC, Brunton LL. Inhibition of protein kinases by balanol: specificity within the serine/threonine protein kinase subfamily. Molecular Pharmacology. 56: 370-6. PMID 10419556 DOI: 10.1124/Mol.56.2.370  0.83
1999 Smith CM, Radzio-Andzelm E, Akamine P, Taylor SS. The catalytic subunit of cAMP-dependent protein kinase: prototype for an extended network of communication. Progress in Biophysics and Molecular Biology. 71: 313-41. PMID 10354702 DOI: 10.1016/S0079-6107(98)00059-5  0.832
1999 Huang LJ, Wang L, Ma Y, Durick K, Perkins G, Deerinck TJ, Ellisman MH, Taylor SS. NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum. The Journal of Cell Biology. 145: 951-9. PMID 10352013 DOI: 10.1083/Jcb.145.5.951  0.552
1999 Hauer JA, Taylor SS, Johnson DA. Binding-dependent disorder-order transition in PKI alpha: a fluorescence anisotropy study. Biochemistry. 38: 6774-80. PMID 10346898 DOI: 10.1021/Bi983074K  0.413
1999 Herberg FW, Doyle ML, Cox S, Taylor SS. Dissection of the nucleotide and metal-phosphate binding sites in cAMP-dependent protein kinase. Biochemistry. 38: 6352-60. PMID 10320366 DOI: 10.1021/Bi982672W  0.432
1999 Harada H, Becknell B, Wilm M, Mann M, Huang LJ, Taylor SS, Scott JD, Korsmeyer SJ. Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Molecular Cell. 3: 413-22. PMID 10230394 DOI: 10.1016/S1097-2765(00)80469-4  0.506
1999 Hauer JA, Barthe P, Taylor SS, Parello J, Padilla A. Two well-defined motifs in the cAMP-dependent protein kinase inhibitor (PKIalpha) correlate with inhibitory and nuclear export function. Protein Science : a Publication of the Protein Society. 8: 545-53. PMID 10091657 DOI: 10.1110/Ps.8.3.545  0.523
1999 Narayana N, Diller TC, Koide K, Bunnage ME, Nicolaou KC, Brunton LL, Xuong NH, Ten Eyck LF, Taylor SS. Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase. Biochemistry. 38: 2367-76. PMID 10029530 DOI: 10.2210/Pdb1Bx6/Pdb  0.823
1999 Hünenberger PH, Helms V, Narayana N, Taylor SS, McCammon JA. Determinants of ligand binding to cAMP-dependent protein kinase. Biochemistry. 38: 2358-66. PMID 10029529 DOI: 10.1021/Bi982064G  0.48
1999 Manoj N, Srinivas VR, Surolia A, Vijayan M, Suguna K, Ravishankar R, Schwarzenbacher R, Zeth K, Diederichs, Kostner GM, Gries A, Laggner P, Prassl R, Madhusudan, Akamine P, ... ... Taylor SS, et al. Contributory presentations/posters Journal of Biosciences. 24: 33-198. DOI: 10.1007/Bf02989373  0.746
1998 Narayana N, Akamine P, Xuong NH, Taylor SS. Crystallization and preliminary X-ray analysis of the unliganded recombinant catalytic subunit of cAMP-dependent protein kinase Acta Crystallographica Section D: Biological Crystallography. 54: 1401-1404. PMID 10089519 DOI: 10.1107/S0907444998005770  0.811
1998 Banky P, Huang LJ, Taylor SS. Dimerization/docking domain of the type Ialpha regulatory subunit of cAMP-dependent protein kinase. Requirements for dimerization and docking are distinct but overlapping. The Journal of Biological Chemistry. 273: 35048-55. PMID 9857038 DOI: 10.1074/Jbc.273.52.35048  0.826
1998 Struppe J, Komives EA, Taylor SS, Vold RR. 2H NMR studies of a myristoylated peptide in neutral and acidic phospholipid bicelles. Biochemistry. 37: 15523-7. PMID 9799515 DOI: 10.1021/Bi981326B  0.36
1998 Cheng X, Shaltiel S, Taylor SS. Mapping substrate-induced conformational changes in cAMP-dependent protein kinase by protein footprinting Biochemistry. 37: 14005-14013. PMID 9760235 DOI: 10.1021/Bi981057P  0.505
1998 Huang LJS, Taylor SS. Dissecting cAMP binding domain A in the R1α subunit of cAMP-dependent protein kinase: Distinct subsites for recognition of cAMP and the catalytic subunit Journal of Biological Chemistry. 273: 26739-26746. PMID 9756917 DOI: 10.1074/Jbc.273.41.26739  0.502
1998 Gangal M, Cox S, Lew J, Clifford T, Garrod SM, Aschbaher M, Taylor SS, Johnson DA. Backbone flexibility of five sites on the catalytic subunit of cAMP- dependent protein kinase in the open and closed conformations Biochemistry. 37: 13728-13735. PMID 9753461 DOI: 10.1021/Bi980560Z  0.494
1998 Cheng X, Ma Y, Moore M, Hemmings BA, Taylor SS. Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 95: 9849-54. PMID 9707564 DOI: 10.1073/Pnas.95.17.9849  0.552
1998 de Lecea L, Criado JR, Rivera S, Wen W, Soriano E, Henriksen SJ, Taylor SS, Gall CM, Sutcliffe JG. Endogenous protein kinase A inhibitor (PKIalpha) modulates synaptic activity. Journal of Neuroscience Research. 53: 269-78. PMID 9698155 DOI: 10.1002/(Sici)1097-4547(19980801)53:3<269::Aid-Jnr1>3.0.Co;2-8  0.366
1998 Grant BD, Hemmer W, Tsigelny I, Adams JA, Taylor SS. Kinetic analyses of mutations in the glycine-rich loop of cAMP-dependent protein kinase. Biochemistry. 37: 7708-15. PMID 9601030 DOI: 10.1021/Bi972987W  0.452
1998 Durick K, Gill GN, Taylor SS. Shc and enigma are both required for mitogenic signaling by Ret/ptc2 Molecular and Cellular Biology. 18: 2298-2308. PMID 9528800 DOI: 10.1128/Mcb.18.4.2298  0.472
1998 Shaltiel S, Cox S, Taylor SS. Conserved water molecules contribute to the extensive network of interactions at the active site of protein kinase A Proceedings of the National Academy of Sciences of the United States of America. 95: 484-491. PMID 9435218 DOI: 10.1073/Pnas.95.2.484  0.504
1998 Smith CM, Shindyalov IN, Veretnik S, Gribskov M, Taylor SS, Ten Eyck LF, Bourne PE. The protein kinase resource. Trends in Biochemical Sciences. 22: 444-6. PMID 9397688 DOI: 10.1016/S0968-0004(97)01131-6  0.471
1997 Taylor SS, Radzio-Andzelm E. Protein kinase inhibition: Natural and synthetic variations on a theme Current Opinion in Chemical Biology. 1: 219-226. PMID 9667861 DOI: 10.1016/S1367-5931(97)80013-0  0.527
1997 Yonemoto W, McGlone ML, Grant B, Taylor SS. Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli. Protein Engineering. 10: 915-25. PMID 9415441 DOI: 10.1093/Protein/10.8.915  0.532
1997 Gibson RM, Taylor SS. Dissecting the cooperative reassociation of the regulatory and catalytic subunits of cAMP-dependent protein kinase. Role of Trp-196 in the catalytic subunit Journal of Biological Chemistry. 272: 31998-32005. PMID 9405392 DOI: 10.1074/Jbc.272.51.31998  0.514
1997 León DA, Herberg FW, Banky P, Taylor SS. A stable alpha-helical domain at the N terminus of the RIalpha subunits of cAMP-dependent protein kinase is a novel dimerization/docking motif. The Journal of Biological Chemistry. 272: 28431-7. PMID 9353302 DOI: 10.1074/Jbc.272.45.28431  0.824
1997 Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS. D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain. Proceedings of the National Academy of Sciences of the United States of America. 94: 11184-9. PMID 9326583 DOI: 10.1073/Pnas.94.21.11184  0.49
1997 Gibson RM, Ji-Buechler Y, Taylor SS. Identification of electrostatic interaction sites between the regulatory and catalytic subunits of cyclic AMP-dependent protein kinase Protein Science. 6: 1825-1834. PMID 9300482 DOI: 10.1002/Pro.5560060903  0.504
1997 Narayana N, Cox S, Xuong NH, Ten Eyck LF, Taylor SS. A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility Structure. 5: 921-935. PMID 9261084 DOI: 10.1016/S0969-2126(97)00246-3  0.703
1997 Hemmer W, McGlone M, Tsigelny I, Taylor SS. Role of the glycine triad in the ATP-binding site of cAMP-dependent protein kinase. The Journal of Biological Chemistry. 272: 16946-54. PMID 9202006 DOI: 10.1074/Jbc.272.27.16946  0.559
1997 Gibson RM, Ji-Buechler Y, Taylor SS. Interaction of the regulatory and catalytic subunits of cAMP-dependent protein kinase: Electrostatic sites on the type Iα regulatory subunit Journal of Biological Chemistry. 272: 16343-16350. PMID 9195940 DOI: 10.1074/Jbc.272.26.16343  0.505
1997 Lew J, Taylor SS, Adams JA. Identification of a partially rate-determining step in the catalytic mechanism of cAMP-dependent protein kinase: a transient kinetic study using stopped-flow fluorescence spectroscopy. Biochemistry. 36: 6717-24. PMID 9184152 DOI: 10.1021/Bi963164U  0.441
1997 Padilla A, Hauer JA, Tsigelny I, Parello J, Taylor SS. Solution structure of synthetic peptide inhibitor and substrate of cAMP-dependent protein kinase. A study by 2D H NMR and molecular dynamics. The Journal of Peptide Research : Official Journal of the American Peptide Society. 49: 210-20. PMID 9151254 DOI: 10.1111/J.1399-3011.1997.Tb00880.X  0.49
1997 Narayana N, Cox S, Shaltiel S, Taylor SS, Xuong NH. Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of camp-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine Biochemistry. 36: 4438-4448. PMID 9109651 DOI: 10.1021/Bi961947+  0.685
1997 Herberg FW, Zimmermann B, McGlone M, Taylor SS. Importance of the A-helix of the catalytic subunit of cAMP-dependent protein kinase for stability and for orienting subdomains at the cleft interface. Protein Science : a Publication of the Protein Society. 6: 569-79. PMID 9070439 DOI: 10.1002/Pro.5560060306  0.563
1997 Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS. Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits. The Journal of Biological Chemistry. 272: 8057-64. PMID 9065479 DOI: 10.1074/Jbc.272.12.8057  0.5
1997 Hemmer W, McGlone M, Taylor SS. Recombinant strategies for rapid purification of catalytic subunits of cAMP-dependent protein kinase Analytical Biochemistry. 245: 115-122. PMID 9056191 DOI: 10.1006/Abio.1996.9952  0.509
1997 Lew J, Coruh N, Tsigelny I, Garrod S, Taylor SS. Synergistic binding of nucleotides and inhibitors to cAMP-dependent protein kinase examined by acrylodan fluorescence spectroscopy Journal of Biological Chemistry. 272: 1507-1513. PMID 8999821 DOI: 10.1074/Jbc.272.3.1507  0.495
1996 Grant BD, Tsigelny I, Adams JA, Taylor SS. Examination of an active-site electrostatic node in the cAMP-dependent protein kinase catalytic subunit. Protein Science : a Publication of the Protein Society. 5: 1316-24. PMID 8819164 DOI: 10.1002/Pro.5560050710  0.54
1996 Tsigelny I, Grant BD, Taylor SS, Ten Eyck LF. Catalytic subunit of cAMP-dependent protein kinase: Electrostatic features and peptide recognition Biopolymers. 39: 353-365. PMID 8756515 DOI: 10.1002/(Sici)1097-0282(199609)39:3<353::Aid-Bip7>3.0.Co;2-N  0.491
1996 Wu R, Durick K, Songyang Z, Cantley LC, Taylor SS, Gill GN. Specificity of LIM domain interactions with receptor tyrosine kinases. The Journal of Biological Chemistry. 271: 15934-41. PMID 8663233 DOI: 10.1074/Jbc.271.27.15934  0.459
1996 Durick K, Wu RY, Gill GN, Taylor SS. Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain. The Journal of Biological Chemistry. 271: 12691-4. PMID 8662982 DOI: 10.1074/Jbc.271.22.12691  0.531
1996 Chestukhin A, Litovchick L, Schourov D, Cox S, Taylor SS, Shaltiel S. Functional malleability of the carboxyl-terminal tail in protein kinase A. The Journal of Biological Chemistry. 271: 10175-82. PMID 8626579 DOI: 10.1074/Jbc.271.17.10175  0.55
1996 Herberg FW, Taylor SS, Dostmann WRG. Active site mutations define the pathway for the cooperative activation of cAMP-dependent protein kinase Biochemistry. 35: 2934-2942. PMID 8608131 DOI: 10.1021/Bi951647C  0.445
1995 Koide K, Bunnage ME, Gomez Paloma L, Kanter JR, Taylor SS, Brunton LL, Nicolaou KC. Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol. Chemistry & Biology. 2: 601-8. PMID 9383464 DOI: 10.1016/1074-5521(95)90124-8  0.475
1995 Andzelm ER, Lew J, Taylor S. Bound to activate: conformational consequences of cyclin binding to CDK2 Structure. 3: 1135-1141. PMID 8591024 DOI: 10.1016/S0969-2126(01)00249-0  0.463
1995 Cox S, Taylor SS. Kinetic analysis of cAMP-dependent protein kinase: Mutations at histidine 87 affect peptide binding and pH dependence Biochemistry. 34: 16203-16209. PMID 8519778 DOI: 10.1021/Bi00049A036  0.438
1995 Adams JA, McGlone ML, Gibson R, Taylor SS. Phosphorylation modulates catalytic function and regulation in the cAMP-dependent protein kinase. Biochemistry. 34: 2447-54. PMID 7873523 DOI: 10.1021/Bi00008A007  0.553
1995 Armstrong R, Wen W, Meinkoth J, Taylor S, Montminy M. A refractory phase in cyclic AMP-responsive transcription requires down regulation of protein kinase A. Molecular and Cellular Biology. 15: 1826-32. PMID 7862172 DOI: 10.1128/Mcb.15.3.1826  0.423
1995 Wen W, Taylor SS, Meinkoth JL. The expression and intracellular distribution of the heat-stable protein kinase inhibitor is cell cycle regulated Journal of Biological Chemistry. 270: 2041-2046. PMID 7836431 DOI: 10.1074/Jbc.270.5.2041  0.373
1995 Su Y, Dostmann WR, Herberg FW, Durick K, Xuong NH, Ten Eyck L, Taylor SS, Varughese KI. Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains. Science (New York, N.Y.). 269: 807-13. PMID 7638597 DOI: 10.1126/Science.7638597  0.552
1995 Wen W, Meinkotht JL, Tsien RY, Taylor SS. Identification of a signal for rapid export of proteins from the nucleus Cell. 82: 463-473. PMID 7634336 DOI: 10.1016/0092-8674(95)90435-2  0.441
1995 Durick K, Yao VJ, Borrello MG, Bongarzone I, Pierotti MA, Taylor SS. Tyrosines outside the kinase core and dimerization are required for the mitogenic activity of RET/ptc2. The Journal of Biological Chemistry. 270: 24642-5. PMID 7559572 DOI: 10.1074/Jbc.270.42.24642  0.5
1995 Taylor SS, Radzio-Andzelm E, Hunter T. How do protein kinases discriminate between serine/threonine and tyrosine? Structural insights from the insulin receptor protein-tyrosine kinase Faseb Journal. 9: 1255-1266. PMID 7557015 DOI: 10.1096/Fasebj.9.13.7557015  0.541
1994 Taylor SS, Radzio-Andzelm E. Three protein kinase structures define a common motif Structure. 2: 345-355. PMID 8081750 DOI: 10.1016/S0969-2126(00)00036-8  0.52
1994 Madhusudan, Trafny EA, Xuong NH, Adams JA, Ten Eyck LF, Taylor SS, Sowadski JM. cAMP-dependent protein kinase: crystallographic insights into substrate recognition and phosphotransfer. Protein Science : a Publication of the Protein Society. 3: 176-87. PMID 8003955 DOI: 10.1002/Pro.5560030203  0.665
1994 Herberg FW, Dostmann WR, Zorn M, Davis SJ, Taylor SS. Crosstalk between domains in the regulatory subunit of cAMP-dependent protein kinase: influence of amino terminus on cAMP binding and holoenzyme formation. Biochemistry. 33: 7485-94. PMID 8003514 DOI: 10.1021/Bi00189A057  0.525
1994 Solberg R, Taskén K, Wen W, Coghlan VM, Meinkoth JL, Scott JD, Jahnsen T, Taylor SS. Human regulatory subunit RI beta of cAMP-dependent protein kinases: expression, holoenzyme formation and microinjection into living cells. Experimental Cell Research. 214: 595-605. PMID 7925653 DOI: 10.1006/Excr.1994.1297  0.367
1994 Cox S, Radzio-Andzelm E, Taylor SS. Domain movements in protein kinases Current Opinion in Structural Biology. 4: 893-901. PMID 7712293 DOI: 10.1016/0959-440X(94)90272-0  0.552
1993 Taylor SS, Knighton DR, Zheng J, Sowadski JM, Gibbs CS, Zoller MJ. A template for the protein kinase family. Trends in Biochemical Sciences. 18: 84-9. PMID 8480367 DOI: 10.1016/0968-0004(93)80001-R  0.53
1993 Su Y, Taylor SS, Dostmann WRG, Xuong NH, Varughese KI. Crystallization of a deletion mutant of the R-subunit of cAMP dependent protein kinase Journal of Molecular Biology. 230: 1091-1093. PMID 8478923 DOI: 10.1006/Jmbi.1993.1224  0.634
1993 Zheng J, Knighton DR, ten Eyck LF, Karlsson R, Xuong N, Taylor SS, Sowadski JM. Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor. Biochemistry. 32: 2154-61. PMID 8443157 DOI: 10.1021/Bi00060A005  0.701
1993 Knighton DR, Cadena DL, Zheng J, Ten Eyck LF, Taylor SS, Sowadski JM, Gill GN. Structural features that specify tyrosine kinase activity deduced from homology modeling of the epidermal growth factor receptor. Proceedings of the National Academy of Sciences of the United States of America. 90: 5001-5. PMID 8389462 DOI: 10.1073/Pnas.90.11.5001  0.536
1993 Marcote MJ, Knighton DR, Basi G, Sowadski JM, Brambilla P, Draetta G, Taylor SS. A three-dimensional model of the Cdc2 protein kinase: localization of cyclin- and Suc1-binding regions and phosphorylation sites. Molecular and Cellular Biology. 13: 5122-31. PMID 8336738 DOI: 10.1128/Mcb.13.8.5122  0.492
1993 Adams JA, Taylor SS. Divalent metal ions influence catalysis and active-site accessibility in the cAMP-dependent protein kinase. Protein Science : a Publication of the Protein Society. 2: 2177-86. PMID 8298463 DOI: 10.1002/Pro.5560021217  0.413
1993 Harootunian AT, Adams SR, Wen W, Meinkoth JL, Taylor SS, Tsien RY. Movement of the free catalytic subunit of cAMP-dependent protein kinase into and out of the nucleus can be explained by diffusion Molecular Biology of the Cell. 4: 993-1002. PMID 8298196 DOI: 10.1091/Mbc.4.10.993  0.429
1993 Herberg FW, Taylor SS. Physiological inhibitors of the catalytic subunit of cAMP-dependent protein kinase: Effect of MgATP on protein-protein interactions Biochemistry. 32: 14015-14022. PMID 8268180 DOI: 10.1021/Bi00213A035  0.488
1993 Zheng J, Knighton DR, Xuong NH, Taylor SS, Sowadski JM, Eyck LFT. Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations Protein Science. 2: 1559-1573. PMID 8251932 DOI: 10.1002/Pro.5560021003  0.696
1993 Herberg FW, Bell SM, Taylor SS. Expression of the catalytic subunit of camp-dependent protein kinase in Escherichia coli: Multiple isozymes reflect different phosphorylation states Protein Engineering, Design and Selection. 6: 771-777. PMID 8248101 DOI: 10.1093/Protein/6.7.771  0.504
1993 Taylor SS, Zheng J, Radzio-Andzelm E, Knighton DR, Ten Eyck LF, Sowadski JM, Herberg FW, Yonemoto WM. cAMP-dependent protein kinase defines a family of enzymes. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 340: 315-24. PMID 8103934 DOI: 10.1098/Rstb.1993.0073  0.571
1993 Meinkoth JL, Alberts AS, Went W, Fantozzi D, Taylor SS, Hagiwara M, Montminy M, Feramisco JR. Signal transduction through the cAMP-dependent protein kinase. Molecular and Cellular Biochemistry. 127: 179-86. PMID 7935349 DOI: 10.1007/Bf01076769  0.459
1993 Veron M, Radzio-Andzelm E, Tsigelny I, Ten Eyck LF, Taylor SS. A conserved helix motif complements the protein kinase core. Proceedings of the National Academy of Sciences of the United States of America. 90: 10618-22. PMID 7504272 DOI: 10.1073/Pnas.90.22.10618  0.569
1993 Taylor SS, Knighton DR, Zheng J, Ten Eyck LF, Sowadski JM. Structural framework for the protein kinase family. Annual Review of Cell Biology. 8: 429-62. PMID 1335745 DOI: 10.1146/Annurev.Cb.08.110192.002241  0.563
1993 Taylor SS, Knighton DR, Zheng J, Ten Eyck LF, Sowadski JM. cAMP-dependent protein kinase and the protein kinase family. Faraday Discussions. 143-52. PMID 1290929 DOI: 10.1039/Fd9929300143  0.568
1992 Zheng JH, Knighton DR, Xuong NH, Parello J, Taylor SS, Sowadski JM. Crystallization studies of the catalytic subunit of cAMP-dependent protein kinase: crystals of murine recombinant catalytic subunit and a mutant, Cys 343----Ser, diffract to 2.7 A resolution Acta Crystallographica. Section B, Structural Science. 48. PMID 1515113 DOI: 10.1107/S0108768192000909  0.64
1992 Knighton DR, Pearson RB, Sowadski JM, Means AR, Ten Eyck LF, Taylor SS, Kemp BE. Structural basis of the intrasteric regulation of myosin light chain kinases. Science (New York, N.Y.). 258: 130-5. PMID 1439761 DOI: 10.1126/Science.1439761  0.493
1992 Adams JA, Taylor SS. Energetic limits of phosphotransfer in the catalytic subunit of cAMP-dependent protein kinase as measured by viscosity experiments. Biochemistry. 31: 8516-22. PMID 1390637 DOI: 10.1021/Bi00151A019  0.46
1992 Mann SKO, Yonemoto WM, Taylor SS, Firtel RA. DdPK3, which plays essential roles during Dictyostelium development, encodes the catalytic subunit of cAMP-dependent protein kinase Proceedings of the National Academy of Sciences of the United States of America. 89: 10701-10705. PMID 1332055 DOI: 10.1073/Pnas.89.22.10701  0.52
1992 Taylor SS, Adams JA. Protein kinases: coming of age Current Opinion in Structural Biology. 2: 743-748. DOI: 10.1016/0959-440X(92)90210-X  0.55
1991 Zoller MJ, Yonemoto W, Taylor SS, Johnson KE. Mammalian cAMP-dependent protein kinase functionally replaces its homolog in yeast Gene. 99: 171-179. PMID 2022331 DOI: 10.1016/0378-1119(91)90124-T  0.474
1991 Yonemoto WM, McGlone ML, Slice LW, Taylor SS. Prokaryotic expression of catalytic subunit of adenosine cyclic monophosphate-dependent protein kinase. Methods in Enzymology. 200: 581-96. PMID 1956337 DOI: 10.1016/0076-6879(91)00173-T  0.52
1991 Zheng JH, Knighton DR, Parello J, Taylor SS, Sowadski JM. Crystallization of catalytic subunit of adenosine cyclic monophosphate-dependent protein kinase. Methods in Enzymology. 200: 508-21. PMID 1956335 DOI: 10.1016/0076-6879(91)00167-U  0.399
1991 Buechler JA, Toner-Webb JA, Taylor SS. Carbodiimides as probes for protein kinase structure and function Methods in Enzymology. 200: 487-500. PMID 1956333 DOI: 10.1016/0076-6879(91)00165-S  0.558
1991 Knighton DR, Zheng J, Ten Eyck LF, Xuong N, Taylor SS, Sowadski JM. Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase Science. 253: 414-420. PMID 1862343 DOI: 10.1126/Science.1862343  0.679
1991 Knighton DR, Zheng JH, Ten Eyck LF, Ashford VA, Xuong NH, Taylor SS, Sowadski JM. Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science (New York, N.Y.). 253: 407-14. PMID 1862342 DOI: 10.1126/Science.1862342  0.545
1991 Knighton DR, Xuong NH, Taylor SS, Sowadski JM. Crystallization studies of cAMP-dependent protein kinase. Cocrystals of the catalytic subunit with a 20 amino acid residue peptide inhibitor and MgATP diffract to 3.0 Å resolution Journal of Molecular Biology. 220: 217-220. PMID 1856856 DOI: 10.1016/0022-2836(91)90005-Q  0.62
1991 León DA, Dostmann WR, Taylor SS. Unfolding of the regulatory subunit of cAMP-dependent protein kinase I. Biochemistry. 30: 3035-40. PMID 1848784 DOI: 10.1021/Bi00226A008  0.465
1991 Adams SR, Harootunian AT, Buechler YJ, Taylor SS, Tsien RY. Fluorescence ratio imaging of cyclic AMP in single cells Nature. 349: 694-697. PMID 1847505 DOI: 10.1038/349694A0  0.353
1991 Neitzel JJ, Dostmann WR, Taylor SS. Role of MgATP in the activation and reassociation of cAMP-dependent protein kinase I: consequences of replacing the essential arginine in cAMP binding site A. Biochemistry. 30: 733-9. PMID 1846304 DOI: 10.1021/Bi00217A023  0.502
1991 Dostmann WR, Taylor SS. Identifying the molecular switches that determine whether (Rp)-cAMPS functions as an antagonist or an agonist in the activation of cAMP-dependent protein kinase I. Biochemistry. 30: 8710-6. PMID 1653606 DOI: 10.1021/Bi00099A032  0.538
1990 Duronio RJ, Jackson-Machelski E, Heuckeroth RO, Olins PO, Devine CS, Yonemoto W, Slice LW, Taylor SS, Gordon JI. Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein modification in bacteria. Proceedings of the National Academy of Sciences of the United States of America. 87: 1506-10. PMID 2406721 DOI: 10.1073/Pnas.87.4.1506  0.341
1990 Meinkoth JL, Ji Y, Taylor SS, Feramisco JR. Dynamics of the distribution of cyclic AMP-dependent protein kinase in living cells. Proceedings of the National Academy of Sciences of the United States of America. 87: 9595-9. PMID 2263615 DOI: 10.1073/Pnas.87.24.9595  0.497
1990 Taylor SS, Buechler JA, Yonemoto W. cAMP-dependent protein kinase: Framework for a diverse family of regulatory enzymes Annual Review of Biochemistry. 59: 971-1105. PMID 2165385 DOI: 10.1146/Annurev.Bi.59.070190.004543  0.559
1989 First EA, Johnson DA, Taylor SS. Fluorescence energy transfer between cysteine 199 and cysteine 343: evidence for MgATP-dependent conformational change in the catalytic subunit of cAMP-dependent protein kinase. Biochemistry. 28: 3606-13. PMID 2787168 DOI: 10.1021/Bi00434A068  0.432
1989 First EA, Taylor SS. Selective modification of the catalytic subunit of cAMP-dependent protein kinase with sulfhydryl-specific fluorescent probes Biochemistry. 28: 3598-3605. PMID 2742857 DOI: 10.1021/Bi00434A067  0.445
1989 Taylor SS. cAMP-dependent protein kinase. Model for an enzyme family Journal of Biological Chemistry. 264: 8443-8446. PMID 2656679 DOI: 10.1016/B978-012124546-7/50560-X  0.334
1989 Buechler JA, Vedvick TA, Taylor SS. Differential labeling of the catalytic subunit of cAMP-dependent protein kinase with acetic anhydride: Substrate-induced conformational changes Biochemistry. 28: 3018-3024. PMID 2500968 DOI: 10.1021/Bi00433A042  0.502
1989 Buechler JA, Taylor SS. Dicyclohexylcarbodiimide cross-links two conserved residues, Asp-184 and Lys-72, at the active site of the catalytic subunit of cAMP-dependent protein kinase Biochemistry. 28: 2065-2070. PMID 2497773 DOI: 10.1021/Bi00431A015  0.455
1988 First EA, Bubis J, Taylor SS. Subunit interaction sites between the regulatory and catalytic subunits of cAMP-dependent protein kinase. Identification of a specific interchain disulfide bond. The Journal of Biological Chemistry. 263: 5176-82. PMID 3356685  0.631
1988 Taylor SS, Bubis J, Toner-Webb J, Saraswat LD, First EA, Buechler JA, Knighton DR, Sowadski J. CAMP-dependent protein kinase: prototype for a family of enzymes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 2: 2677-85. PMID 3294077 DOI: 10.1096/Fasebj.2.11.3294077  0.74
1988 Taylor SS, Buechler JA, Slice LW, Knighton DK, Durgerian S, Ringheim GE, Neitzel JJ, Yonemoto WM, Sowadski JM, Dospmann W. cAMP-dependent protein kinase: A framework for a diverse family of enzymes Cold Spring Harbor Symposia On Quantitative Biology. 53: 121-130. PMID 3076077 DOI: 10.1101/Sqb.1988.053.01.018  0.451
1988 Saraswat LD, Filutowics M, Taylor S. Expression and mutagenesis of the regulatory subunit of cAMP-dependent protein kinase in Escherichia coli. Methods in Enzymology. 159: 325-36. PMID 3045499 DOI: 10.1016/0076-6879(88)59033-X  0.414
1988 Buechler JA, Taylor SS. Identification of aspartate-184 as an essential residue in the catalytic subunit of cAMP-dependent protein kinase Biochemistry. 27: 7356-7361. PMID 2905166 DOI: 10.1021/Bi00419A027  0.474
1988 Bubis J, Neitzel JJ, Saraswat LD, Taylor SS. A point mutation abolishes binding of cAMP to site A in the regulatory subunit of cAMP-dependent protein kinase. The Journal of Biological Chemistry. 263: 9668-73. PMID 2898473  0.653
1988 Ringheim GE, Saraswat LD, Bubis J, Taylor SS. Deletion of cAMP-binding site B in the regulatory subunit of cAMP-dependent protein kinase alters the photoaffinity labeling of site A. The Journal of Biological Chemistry. 263: 18247-52. PMID 2848031  0.65
1988 Saraswat LD, Ringheim GE, Bubis J, Taylor SS. Deletion mutants as probes for localizing regions of subunit interaction in cAMP-dependent protein kinase. The Journal of Biological Chemistry. 263: 18241-6. PMID 2848030  0.697
1988 Bubis J, Saraswat LD, Taylor SS. Tyrosine-371 contributes to the positive cooperativity between the two cAMP binding sites in the regulatory subunit of cAMP-dependent protein kinase I. Biochemistry. 27: 1570-6. PMID 2835094 DOI: 10.1021/Bi00405A026  0.707
1988 Taylor SS, Bubis J, Sowadski J, Toner JA, Saraswat LD. Relation Between Structure and Function in cAMP-Dependent Protein Kinases Annals of the New York Academy of Sciences. 478: 327-341. DOI: 10.1007/978-1-4612-3744-0_38  0.74
1987 Bubis J, Taylor SS. Limited proteolysis alters the photoaffinity labeling of adenosine 3',5'-monophosphate dependent protein kinase II with 8-azidoadenosine 3',5'-monophosphate. Biochemistry. 26: 5997-6004. PMID 3689756 DOI: 10.1021/Bi00393A008  0.685
1987 Bubis J, Vedvick TS, Taylor SS. Antiparallel alignment of the two protomers of the regulatory subunit dimer of cAMP-dependent protein kinase I. The Journal of Biological Chemistry. 262: 14961-6. PMID 3667618  0.658
1987 Toner-Webb J, Taylor SS. Inhibition of the catalytic subunit of cAMP-dependent protein kinase by dicyclohexylcarbodiimide Biochemistry. 26: 7371-7378. PMID 3501317 DOI: 10.1021/Bi00397A026  0.474
1987 Weber IT, Steitz TA, Bubis J, Taylor SS. Predicted structures of cAMP binding domains of type I and II regulatory subunits of cAMP-dependent protein kinase. Biochemistry. 26: 343-51. PMID 3030405 DOI: 10.1021/Bi00376A003  0.717
1987 Bubis J, Taylor SS. Correlation of photolabeling with occupancy of cAMP binding sites in the regulatory subunit of cAMP-dependent protein kinase I. Biochemistry. 26: 3478-86. PMID 2820470 DOI: 10.1021/Bi00386A035  0.665
1987 Taylor SS. Protein kinases: A diverse family of related proteins Bioessays. 7: 24-29. PMID 2820389 DOI: 10.1002/Bies.950070106  0.524
1987 Taylor P, Schumacher M, MacPhee-Quigley K, Friedmann T, Taylor S. The structure of acetylcholinesterase: relationship to its function and cellular disposition Trends in Neurosciences. 10: 93-95. DOI: 10.1016/0166-2236(87)90033-6  0.356
1986 Schumacher M, Camp S, Maulet Y, Newton M, MacPhee-Quigley K, Taylor SS, Friedmann T, Taylor P. Primary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence. Nature. 319: 407-9. PMID 3753747 DOI: 10.1038/319407A0  0.361
1986 Taylor SS, Saraswat LD, Toner JA, Bubis J. The relationship between structure and function in cAMP-dependent protein kinases. Annals of the New York Academy of Sciences. 478: 191-202. PMID 3026223 DOI: 10.1111/J.1749-6632.1986.Tb15531.X  0.682
1985 Sowadski JM, Xuong Nh, Anderson D, Taylor SS. Crystallization studies of cAMP-dependent protein kinase. Crystals of catalytic subunit diffract to 3.5 Å resolution Journal of Molecular Biology. 182: 617-620. PMID 4009717 DOI: 10.1016/0022-2836(85)90249-9  0.622
1985 Dothie JM, Giglio JR, Moore CB, Taylor SS, Hartley BS. Ribitol dehydrogenase of Klebsiella aerogenes. Sequence and properties of wild-type and mutant strains. The Biochemical Journal. 230: 569-78. PMID 3904726 DOI: 10.1042/Bj2300569  0.54
1985 Jurgensen SR, Chock PB, Taylor S, Vandenheede JR, Merlevede W. Inhibition of the Mg(II).ATP-dependent phosphoprotein phosphatase by the regulatory subunit of cAMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 82: 7565-9. PMID 2999770 DOI: 10.1073/Pnas.82.22.7565  0.508
1985 Bubis J, Taylor SS. Covalent modification of both cAMP binding sites in cAMP-dependent protein kinase I by 8-azidoadenosine 3',5'-monophosphate. Biochemistry. 24: 2163-70. PMID 2986689 DOI: 10.1021/Bi00330A009  0.71
1985 Mumby MC, Weldon SL, Scott CW, Taylor SS. Monoclonal antibodies as probes of structure, function and isoenzyme forms of the type II regulatory subunit of cyclic AMP-dependent protein kinase. Pharmacology & Therapeutics. 28: 367-87. PMID 2418450 DOI: 10.1016/0163-7258(85)90059-2  0.395
1984 Kamps MP, Taylor SS, Sefton BM. Direct evidence that oncogenic tyrosine kinases and cyclic AMP-dependent protein kinase have homologous ATP-binding sites. Nature. 310: 589-92. PMID 6431300 DOI: 10.1038/310589A0  0.56
1984 Taylor SS, Kerlavage AR, Zoller MJ. Affinity labeling of cAMP-dependent protein kinases. Methods in Enzymology. 99: 140-53. PMID 6316084 DOI: 10.1016/0076-6879(83)99047-X  0.464
1983 Siebenaller JF, Orr TL, Olwin BB, Taylor SS. Comparison of the D-lactate stereospecific dehydrogenase of Limulus polyphemus with active-site regions of L-lactate dehydrogenases. Biochimica Et Biophysica Acta. 749: 153-62. PMID 6652095 DOI: 10.1016/0167-4838(83)90247-9  0.322
1983 Doctor BP, Camp S, Gentry MK, Taylor SS, Taylor P. Antigenic and structural differences in the catalytic subunits of the molecular forms of acetylcholinesterase. Proceedings of the National Academy of Sciences of the United States of America. 80: 5767-71. PMID 6193524 DOI: 10.1073/Pnas.80.18.5767  0.322
1978 Potter RL, Stafford PH, Taylor S. Regulatory subunit of cyclic AMP-dependent protein kinase I from porcine skeletal muscle: purification and proteolysis. Archives of Biochemistry and Biophysics. 190: 174-80. PMID 213029 DOI: 10.1016/0003-9861(78)90265-5  0.438
1978 Taylor SS, Dixon JE. Affinity chromatography of lactate dehydrogenase. A biochemistry experiment Journal of Chemical Education. 55: 675. DOI: 10.1021/Ed055P675  0.466
1976 Taylor SS, Oxley SS. Homologies in the active site regions of lactate dehydrogenases Archives of Biochemistry and Biophysics. 175: 373-383. PMID 962329 DOI: 10.1016/0003-9861(76)90524-5  0.351
1976 Taylor SS, Lee CY, Swain L, Stafford PH. Cyclic AMP-dependent protein kinase: Purification of the holoenzyme by affinity chromatography Analytical Biochemistry. 76: 45-52. PMID 187080 DOI: 10.1016/0003-2697(76)90262-1  0.455
1975 Taylor SS, Allison WS, Kaplan NO. The amino acid sequence of the tryptic peptides isolated from dogfish M4 lactate dehydrogenase. The Journal of Biological Chemistry. 250: 8740-7. PMID 1184589  0.621
1974 Taylor SS, Rigby PW, Hartley BS. Ribitol dehydrogenase from Klebsiella aerogenes. Purification and subunit structure. The Biochemical Journal. 141: 693-700. PMID 4618776 DOI: 10.1042/Bj1410693  0.566
1974 Kaplan NO, Everse J, Dixon JE, Stolzenbach FE, Lee CY, Lee CL, Taylor SS, Mosbach K. Purification and separation of pyridine nucleotide-linked dehydrogenases by affinity chromatography techniques. Proceedings of the National Academy of Sciences of the United States of America. 71: 3450-4. PMID 4372619 DOI: 10.1073/Pnas.71.9.3450  0.618
1973 Taylor SS, Oxley SS, Allison WS, Kaplan NO. Aminoacid sequence of dogfish M4 lactate dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America. 70: 1790-3. PMID 4515938 DOI: 10.1073/Pnas.70.6.1790  0.658
1973 Adams MJ, Buehner M, Chandrasekhar K, Ford GC, Hackert ML, Liljas A, Rossmann MG, Smiley IE, Allison WS, Everse J, Kaplan NO, Taylor SS. Structure-function relationships in lactate dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America. 70: 1968-72. PMID 4146647 DOI: 10.1073/Pnas.70.7.1968  0.717
1969 Taylor SS, Heath EC. The incorporation of beta-hydroxy fatty acids into a phospholipid of Escherichia coli B. The Journal of Biological Chemistry. 244: 6605-16. PMID 4902888  0.519
Low-probability matches (unlikely to be authored by this person)
2003 Brinen LS, Canaves JM, Dai X, Deacon AM, Elsliger MA, Eshaghi S, Floyd R, Godzik A, Grittini C, Grzechnik SK, Guda C, Jaroszewski L, Karlak C, Klock HE, Koesema E, ... ... Taylor SS, et al. Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 1.5 A resolution. Proteins. 50: 371-4. PMID 12486729 DOI: 10.1002/Prot.10302  0.292
2023 Wych DC, Aoto PC, Vu L, Wolff AM, Mobley DL, Fraser JS, Taylor SS, Wall ME. Molecular-dynamics simulation methods for macromolecular crystallography. Acta Crystallographica. Section D, Structural Biology. 79: 50-65. PMID 36601807 DOI: 10.1107/S2059798322011871  0.288
2023 Jones AC, Kornev AP, Weng JH, Manning G, Taylor SS, Newton AC. Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration. Biorxiv : the Preprint Server For Biology. PMID 36993163 DOI: 10.1101/2023.03.16.532226  0.288
2023 Jones AC, Kornev AP, Weng JH, Manning G, Taylor S, Newton AC. Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration. The Biochemical Journal. PMID 37551632 DOI: 10.1042/BCJ20220397  0.285
2012 Taylor S, Ilouz R, Darshi M, Kornev A, Zhang P. PKA: Assembly of Dynamic Macromolecular Signaling Hormone and Metabolic Research. 44. DOI: 10.1055/S-0032-1304250  0.284
2021 Ramms DJ, Raimondi F, Arang N, Herberg FW, Taylor SS, Gutkind JS. Gs-Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Gs-PKA Signaling. Pharmacological Reviews. 73: 155-197. PMID 34663687 DOI: 10.1124/pharmrev.120.000269  0.281
1977 Eventoff W, Rossmann MG, Taylor SS, Torff HJ, Meyer H, Keil W, Kiltz HH. Structural adaptations of lactate dehydrogenase isozymes Proceedings of the National Academy of Sciences of the United States of America. 74: 2677-2681. PMID 197516 DOI: 10.1073/Pnas.74.7.2677  0.275
2008 Ma Y, Taylor SS. A molecular switch for targeting between endoplasmic reticulum (ER) and mitochondria: conversion of a mitochondria-targeting element into an ER-targeting signal in DAKAP1. The Journal of Biological Chemistry. 283: 11743-51. PMID 18287098 DOI: 10.1074/Jbc.M710494200  0.273
2013 Okada H, Lai NC, Kawaraguchi Y, Liao P, Copps J, Sugano Y, Okada-Maeda S, Banerjee I, Schilling JM, Gingras AR, Asfaw EK, Suarez J, Kang SM, Perkins GA, Au CG, ... ... Taylor SS, et al. Integrins protect cardiomyocytes from ischemia/reperfusion injury. The Journal of Clinical Investigation. 123: 4294-308. PMID 24091324 DOI: 10.1172/Jci64216  0.269
2010 Perera D, Taylor SS. Sgo1 establishes the centromeric cohesion protection mechanism in G2 before subsequent Bub1-dependent recruitment in mitosis. Journal of Cell Science. 123: 653-9. PMID 20124418 DOI: 10.1242/Jcs.059501  0.268
2017 Zhao X, Deng P, Iglesias-Bartolome R, Amornphimoltham P, Steffen DJ, Jin Y, Molinolo AA, de Castro LF, Ovejero D, Yuan Q, Chen Q, Han X, Bai D, Taylor SS, Yang Y, et al. Expression of an active Gαs mutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance. Proceedings of the National Academy of Sciences of the United States of America. PMID 29282319 DOI: 10.1073/Pnas.1713710115  0.266
2015 Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel AR, et al. p75 Neurotrophin Receptor Regulates Energy Balance in Obesity. Cell Reports. PMID 26748707 DOI: 10.1016/J.Celrep.2015.12.028  0.264
2011 Lara-Gonzalez P, Scott MI, Diez M, Sen O, Taylor SS. BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner. Journal of Cell Science. 124: 4332-45. PMID 22193957 DOI: 10.1242/Jcs.094763  0.264
2014 Pfanner N, van der Laan M, Amati P, Capaldi RA, Caudy AA, Chacinska A, Darshi M, Deckers M, Hoppins S, Icho T, Jakobs S, Ji J, Kozjak-Pavlovic V, Meisinger C, Odgren PR, ... ... Taylor SS, et al. Uniform nomenclature for the mitochondrial contact site and cristae organizing system. The Journal of Cell Biology. 204: 1083-6. PMID 24687277 DOI: 10.1083/Jcb.201401006  0.258
2011 Taylor SS, Ilouz R, Darshi M, Sarma G, Kornev A, Zhang P. PKA: assembly of dynamic macromolecular signaling Bmc Pharmacology. 11. DOI: 10.1186/1471-2210-11-S1-O12  0.251
2013 Laanemets K, Brandt B, Li J, Merilo E, Wang YF, Keshwani MM, Taylor SS, Kollist H, Schroeder JI. Calcium-dependent and -independent stomatal signaling network and compensatory feedback control of stomatal opening via Ca2+ sensitivity priming. Plant Physiology. 163: 504-13. PMID 23766366 DOI: 10.1104/Pp.113.220343  0.248
2020 Watanabe R, Buschauer R, Böhning J, Audagnotto M, Lasker K, Wen Lu T, Boassa D, Taylor SS, Villa E. The In situ Structure of Parkinson's Disease-Linked LRRK2 Biophysical Journal. 118: 486a. DOI: 10.1016/J.Bpj.2019.11.2690  0.243
2019 Cao B, Lu TW, Fiesco JAM, Tomasini M, Fan L, Simon SM, Taylor SS, Zhang P. Structures of the PKA RI alpha Holoenzyme with the FLHCC Driver J-PKAc alpha or Wild-Type PKAc alpha. Structure. 27: 816. DOI: 10.2210/Pdb6Byr/Pdb  0.242
2022 Thomas R, Hernandez A, Benavides DR, Li W, Tan C, Umfress A, Plattner F, Chakraborti A, Pozzo-Miller L, Taylor SS, Bibb JA. Integrated regulation of PKA by fast and slow neurotransmission in the nucleus accumbens controls plasticity and stress responses. The Journal of Biological Chemistry. 102245. PMID 35835216 DOI: 10.1016/j.jbc.2022.102245  0.239
2023 Madan LK, Welsh CL, Kornev AP, Taylor SS. The "violin model": Looking at community networks for dynamic allostery. The Journal of Chemical Physics. 158: 081001. PMID 36859094 DOI: 10.1063/5.0138175  0.231
2010 Westhorpe FG, Diez MA, Gurden MD, Tighe A, Taylor SS. Re-evaluating the role of Tao1 in the spindle checkpoint. Chromosoma. 119: 371-9. PMID 20162290 DOI: 10.1007/S00412-010-0261-1  0.225
2020 Palencia-Campos A, Aoto PC, Machal EMF, Rivera-Barahona A, Soto-Bielicka P, Bertinetti D, Baker B, Vu L, Piceci-Sparascio F, Torrente I, Boudin E, Peeters S, Van Hul W, Huber C, Bonneau D, ... ... Taylor SS, et al. Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome. American Journal of Human Genetics. PMID 33058759 DOI: 10.1016/j.ajhg.2020.09.005  0.223
2015 Matthews LC, Berry AA, Morgan DJ, Poolman TM, Bauer K, Kramer F, Spiller DG, Richardson RV, Chapman KE, Farrow SN, Norman MR, Williamson AJ, Whetton AD, Taylor SS, Tuckermann JP, et al. Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy. Proceedings of the National Academy of Sciences of the United States of America. 112: 5479-84. PMID 25847991 DOI: 10.1073/Pnas.1411356112  0.218
2015 Wei SC, Fattet L, Tsai JH, Guo Y, Pai VH, Majeski HE, Chen AC, Sah RL, Taylor SS, Engler AJ, Yang J. Matrix stiffness drives epithelial-mesenchymal transition and tumour metastasis through a TWIST1-G3BP2 mechanotransduction pathway. Nature Cell Biology. 17: 678-88. PMID 25893917 DOI: 10.1038/Ncb3157  0.216
2010 Santaguida S, Tighe A, D'Alise AM, Taylor SS, Musacchio A. Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. The Journal of Cell Biology. 190: 73-87. PMID 20624901 DOI: 10.1083/Jcb.201001036  0.216
2013 Lee YS, Morinaga H, Kim JJ, Lagakos W, Taylor S, Keshwani M, Perkins G, Dong H, Kayali AG, Sweet IR, Olefsky J. The Fractalkine/CX3CR1 System Regulates β Cell Function and Insulin Secretion Cell. 153: 413-425. PMID 23582329 DOI: 10.1016/J.Cell.2013.03.001  0.213
2011 Akhtar A, Fuchs E, Mitchison T, Shaw RJ, St Johnston D, Strasser A, Taylor S, Walczak C, Zerial M. A decade of molecular cell biology: achievements and challenges. Nature Reviews. Molecular Cell Biology. 12: 669-74. PMID 21941276 DOI: 10.1038/Nrm3187  0.213
2015 Malmstrom RD, Kornev AP, Taylor SS, Amaro RE. Allostery through the computational microscope: CAMP activation of a canonical signalling domain Nature Communications. 6. DOI: 10.1038/ncomms8588  0.213
2016 Taylor S, Minor K, Shmon CL, Shelton GD, Patterson EE, Mickelson JR. Border Collie Collapse: Owner Survey Results and Veterinary Description of Videotaped Episodes. Journal of the American Animal Hospital Association. PMID 27685362 DOI: 10.5326/Jaaha-Ms-6436  0.202
2010 Hewitt L, Tighe A, Santaguida S, White AM, Jones CD, Musacchio A, Green S, Taylor SS. Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex. The Journal of Cell Biology. 190: 25-34. PMID 20624899 DOI: 10.1083/Jcb.201002133  0.198
2012 Lara-Gonzalez P, Taylor SS. Cohesion fatigue explains why pharmacological inhibition of the APC/C induces a spindle checkpoint-dependent mitotic arrest. Plos One. 7: e49041. PMID 23145059 DOI: 10.1371/Journal.Pone.0049041  0.194
2015 Aspinall CF, Zheleva D, Tighe A, Taylor SS. Mitotic entry: Non-genetic heterogeneity exposes the requirement for Plk1. Oncotarget. PMID 26472023 DOI: 10.18632/Oncotarget.5507  0.188
2020 Steffen DJ, Tiriac H, Valera JLC, Amornphimoltham P, Kim W, Taylor S, Hunter T, Tamayo P, Gutkind JS. Gαs ( GNAS ) suppression of the p53 genomic‐stability checkpoint unleashes RAS ‐driven oncogenesis The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04604  0.186
1998 Borén J, Lee I, Zhu W, Arnold K, Taylor S, Innerarity TL. Identification of the low density lipoprotein receptor-binding site in apolipoprotein B100 and the modulation of its binding activity by the carboxyl terminus in familial defective Apo-B100 Journal of Clinical Investigation. 101: 1084-1093. PMID 9486979 DOI: 10.1172/JCI1847  0.184
2000 Cheesman EJ, Sharp RJ, Zlot CH, Liu CY, Taylor S, Marcovina SM, Young SG, McCormick SP. An analysis of the interaction between mouse apolipoprotein B100 and apolipoprotein(a). The Journal of Biological Chemistry. 275: 28195-200. PMID 10837476 DOI: 10.1074/jbc.M002772200  0.18
2016 Taylor S, Shmon C, Su L, Epp T, Minor K, Mickelson J, Patterson E, Shelton GD. Evaluation of Dogs with Border Collie Collapse, Including Response to Two Standardized Strenuous Exercise Protocols. Journal of the American Animal Hospital Association. PMID 27487345 DOI: 10.5326/Jaaha-Ms-6361  0.179
2010 Gurden MD, Holland AJ, van Zon W, Tighe A, Vergnolle MA, Andres DA, Spielmann HP, Malumbres M, Wolthuis RM, Cleveland DW, Taylor SS. Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F. Journal of Cell Science. 123: 321-30. PMID 20053638 DOI: 10.1242/Jcs.062075  0.177
2015 Diez V, Loznik M, Taylor S, Winn M, Rattray NJ, Podmore H, Micklefield J, Goodacre R, Medema MH, Müller U, Bovenberg R, Janssen DB, Takano E. Functional Exchangeability of Oxidase and Dehydrogenase Reactions in the Biosynthesis of Hydroxyphenylglycine, a Nonribosomal Peptide Building Block. Acs Synthetic Biology. 4: 796-807. PMID 25713978 DOI: 10.1021/Sb500368W  0.169
2013 Taylor SS, Dodkin S, Papasouliotis K, Evans H, Graham PA, Belshaw Z, Westberg S, von Euler HP. Serum thymidine kinase activity in clinically healthy and diseased cats: a potential biomarker for lymphoma. Journal of Feline Medicine and Surgery. 15: 142-7. PMID 23076596 DOI: 10.1177/1098612X12463928  0.165
2015 Picaud S, Fedorov O, Thanasopoulou A, Leonards K, Jones K, Meier J, Olzscha H, Monteiro O, Martin S, Philpott M, Tumber A, Filippakopoulos P, Yapp C, Wells C, Hing Che K, ... ... Taylor S, et al. Generation of a selective small molecule inhibitor of the CBP/p300 bromodomain for leukemia therapy. Cancer Research. PMID 26552700 DOI: 10.1158/0008-5472.Can-15-0236  0.158
2011 Westhorpe FG, Tighe A, Lara-Gonzalez P, Taylor SS. p31comet-mediated extraction of Mad2 from the MCC promotes efficient mitotic exit. Journal of Cell Science. 124: 3905-16. PMID 22100920 DOI: 10.1242/Jcs.093286  0.156
1995 Ahmed M, Lyass L, Markham PN, Taylor SS, Vazquez-Laslop N, Neyfakh AA. Two highly similar multidrug transporters of Bacillus subtilis whose expression is differentially regulated Journal of Bacteriology. 177: 3904-3910. PMID 7608059 DOI: 10.1128/JB.177.14.3904-3910.1995  0.15
2015 Taylor S, Dontsova K, Walsh ME, Walsh MR. Outdoor dissolution of detonation residues of three insensitive munitions (IM) formulations. Chemosphere. 134: 250-6. PMID 25966455 DOI: 10.1016/j.chemosphere.2015.04.041  0.147
2005 Hewitt AD, Jenkins TF, Walsh ME, Walsh MR, Taylor S. RDX and TNT residues from live-fire and blow-in-place detonations. Chemosphere. 61: 888-94. PMID 15964048 DOI: 10.1016/j.chemosphere.2005.04.058  0.137
2015 Baker EK, Taylor S, Gupte A, Sharp PP, Walia M, Walsh NC, Zannettino AC, Chalk AM, Burns CJ, Walkley CR. BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells. Scientific Reports. 5: 10120. PMID 25944566 DOI: 10.1038/srep10120  0.131
2015 Jarvis SP, Taylor S, Baran JD, Thompson D, Saywell A, Mangham B, Champness NR, Larsson JA, Moriarty P. Physisorption Controls the Conformation and Density of States of an Adsorbed Porphyrin Journal of Physical Chemistry C. 119: 27982-27994. DOI: 10.1021/Acs.Jpcc.5B08350  0.126
1997 McCormick SP, Ng JK, Cham CM, Taylor S, Marcovina SM, Segrest JP, Hammer RE, Young SG. Transgenic mice expressing human ApoB95 and ApoB97. Evidence that sequences within the carboxyl-terminal portion of human apoB100 are important for the assembly of lipoprotein. The Journal of Biological Chemistry. 272: 23616-22. PMID 9295301 DOI: 10.1074/jbc.272.38.23616  0.123
2024 Weng JH, Trilling CR, Kaila Sharma P, Störmer E, Wu J, Herberg FW, Taylor SS. Corrigendum to "Novel LRR-ROC Motif That Links the N- and C-terminal Domains in LRRK2 Undergoes an Order-Disorder Transition Upon Activation" [J. Mol. Biol. 435(12) (2023) 1-17]. Journal of Molecular Biology. 168485. PMID 38369414 DOI: 10.1016/j.jmb.2024.168485  0.12
2010 Walsh ME, Taylor S, Hewitt AD, Walsh MR, Ramsey CA, Collins CM. Field observations of the persistence of Comp B explosives residues in a salt marsh impact area. Chemosphere. 78: 467-73. PMID 19883934 DOI: 10.1016/j.chemosphere.2009.10.021  0.118
2015 Carter JR, Taylor S, Fraser TS, Kucharski CA, Dawson JL, Fraser MJ. Suppression of the Arboviruses Dengue and Chikungunya Using a Dual-Acting Group-I Intron Coupled with Conditional Expression of the Bax C-Terminal Domain. Plos One. 10: e0139899. PMID 26580561 DOI: 10.1371/journal.pone.0139899  0.115
1997 Allan CM, Taylor S, Taylor JM. Two hepatic enhancers, HCR.1 and HCR.2, coordinate the liver expression of the entire human apolipoprotein E/C-I/C-IV/C-II gene cluster. The Journal of Biological Chemistry. 272: 29113-9. PMID 9360987 DOI: 10.1074/jbc.272.46.29113  0.108
2013 Taylor S, Ringelberg DB, Dontsova K, Daghlian CP, Walsh ME, Walsh MR. Insights into the dissolution and the three-dimensional structure of insensitive munitions formulations. Chemosphere. 93: 1782-8. PMID 23916749 DOI: 10.1016/j.chemosphere.2013.06.011  0.107
2015 Davies JO, Telenius JM, McGowan SJ, Roberts NA, Taylor S, Higgs DR, Hughes JR. Multiplexed analysis of chromosome conformation at vastly improved sensitivity. Nature Methods. PMID 26595209 DOI: 10.1038/Nmeth.3664  0.106
2015 Thiruppathy K, Taylor S, Kuan KG, Cohen R, Halligan S, Emmanuel A. Two-dimensional Endoanal Ultrasound Scan Correlates with External Anal Sphincter Structure and Function, but not with Puborectalis Journal of Medical Ultrasound. 23: 164-170. DOI: 10.1016/j.jmu.2015.08.004  0.097
2015 Gramage E, D'Cruz T, Taylor S, Thummel R, Hitchcock PF. Midkine-a protein localization in the developing and adult retina of the zebrafish and its function during photoreceptor regeneration. Plos One. 10: e0121789. PMID 25803551 DOI: 10.1371/Journal.Pone.0121789  0.096
2011 Tappin SW, Taylor SS, Tasker S, Dodkin SJ, Papasouliotis K, Murphy KF. Serum protein electrophoresis in 147 dogs. The Veterinary Record. 168: 456. PMID 21493443 DOI: 10.1136/vr.d88  0.096
2015 Taylor S, Ominsky MS, Hu R, Pacheco E, He YD, Brown DL, Aguirre JI, Wronski TJ, Buntich S, Afshari CA, Pyrah I, Nioi P, Boyce RW. Time-dependent cellular and transcriptional changes in the osteoblast lineage associated with sclerostin antibody treatment in ovariectomized rats. Bone. PMID 26721737 DOI: 10.1016/j.bone.2015.12.013  0.096
2015 Bennett A, Bechi B, Tighe A, Thompson S, Procter DJ, Taylor SS. Cenp-E inhibitor GSK923295: Novel synthetic route and use as a tool to generate aneuploidy. Oncotarget. 6: 20921-32. PMID 26320186 DOI: 10.18632/Oncotarget.4879  0.096
2012 Lara-Gonzalez P, Westhorpe FG, Taylor SS. The spindle assembly checkpoint. Current Biology : Cb. 22: R966-80. PMID 23174302 DOI: 10.1016/J.Cub.2012.10.006  0.095
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