Leor S. Weinberger - Publications

2011 Chemistry and Biochemistry University of California, San Diego, La Jolla, CA 
 2011- University of California, San Francisco, San Francisco, CA 
Systems Biology, Virology, Single-Cell Imaging, and Computational Modeling

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Year Citation  Score
2019 Hansen MMK, Weinberger LS. Post-Transcriptional Noise Control. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 41: e1900044. PMID 31222776 DOI: 10.1002/bies.201900044  0.4
2018 Hansen MMK, Desai RV, Simpson ML, Weinberger LS. Cytoplasmic Amplification of Transcriptional Noise Generates Substantial Cell-to-Cell Variability. Cell Systems. PMID 30243562 DOI: 10.1016/j.cels.2018.08.002  0.4
2018 Hansen MMK, Wen WY, Ingerman E, Razooky BS, Thompson CE, Dar RD, Chin CW, Simpson ML, Weinberger LS. A Post-Transcriptional Feedback Mechanism for Noise Suppression and Fate Stabilization. Cell. PMID 29754821 DOI: 10.1016/j.cell.2018.04.005  1
2017 Razooky BS, Cao Y, Hansen MMK, Perelson AS, Simpson ML, Weinberger LS. Nonlatching positive feedback enables robust bimodality by decoupling expression noise from the mean. Plos Biology. 15: e2000841. PMID 29045398 DOI: 10.1371/journal.pbio.2000841  1
2016 Dar RD, Shaffer SM, Singh A, Razooky BS, Simpson ML, Raj A, Weinberger LS. Transcriptional Bursting Explains the Noise-Versus-Mean Relationship in mRNA and Protein Levels. Plos One. 11: e0158298. PMID 27467384 DOI: 10.1371/journal.pone.0158298  1
2016 Rast LI, Rouzine IM, Rozhnova G, Bishop L, Weinberger AD, Weinberger LS. Conflicting Selection Pressures Will Constrain Viral Escape from Interfering Particles: Principles for Designing Resistance-Proof Antivirals. Plos Computational Biology. 12: e1004799. PMID 27152856 DOI: 10.1371/journal.pcbi.1004799  0.76
2015 Dar RD, Razooky BS, Weinberger LS, Cox CD, Simpson ML. The Low Noise Limit in Gene Expression. Plos One. 10: e0140969. PMID 26488303 DOI: 10.1371/journal.pone.0140969  1
2015 Rouzine IM, Weinberger AD, Weinberger LS. An evolutionary role for HIV latency in enhancing viral transmission. Cell. 160: 1002-12. PMID 25723173 DOI: 10.1016/j.cell.2015.02.017  0.76
2015 Razooky BS, Pai A, Aull K, Rouzine IM, Weinberger LS. A hardwired HIV latency program. Cell. 160: 990-1001. PMID 25723172 DOI: 10.1016/j.cell.2015.02.009  0.76
2015 Jung SY, Notton T, Fong E, Shusteff M, Weinberger LS. Spatial tuning of acoustofluidic pressure nodes by altering net sonic velocity enables high-throughput, efficient cell sorting. Lab On a Chip. 15: 1000-3. PMID 25563937 DOI: 10.1039/c4lc01342e  0.76
2014 Rouzine IM, Razooky BS, Weinberger LS. Stochastic variability in HIV affects viral eradication. Proceedings of the National Academy of Sciences of the United States of America. 111: 13251-2. PMID 25201951 DOI: 10.1073/pnas.1413362111  0.76
2014 Notton T, Sardanyés J, Weinberger AD, Weinberger LS. The case for transmissible antivirals to control population-wide infectious disease. Trends in Biotechnology. 32: 400-5. PMID 25017994 DOI: 10.1016/j.tibtech.2014.06.006  0.76
2014 Dar RD, Hosmane NN, Arkin MR, Siliciano RF, Weinberger LS. Screening for noise in gene expression identifies drug synergies. Science (New York, N.Y.). 344: 1392-6. PMID 24903562 DOI: 10.1126/science.1250220  0.76
2014 Rouzine IM, Coffin JM, Weinberger LS. Fifteen years later: hard and soft selection sweeps confirm a large population number for HIV in vivo. Plos Genetics. 10: e1004179. PMID 24586204 DOI: 10.1371/journal.pgen.1004179  0.76
2014 Fong EJ, Johnston AC, Notton T, Jung SY, Rose KA, Weinberger LS, Shusteff M. Acoustic focusing with engineered node locations for high-performance microfluidic particle separation. The Analyst. 139: 1192-200. PMID 24448925 DOI: 10.1039/c4an00034j  0.76
2014 Fong EJ, Bora M, Jung SY, Johnston A, Notton T, Weinberger LS, Shusteff M. Continuously variable node position in a high-throughput acoustofluidic device 18th International Conference On Miniaturized Systems For Chemistry and Life Sciences, Microtas 2014. 1184-1186.  0.76
2013 Weinberger AD, Weinberger LS. Stochastic fate selection in HIV-infected patients. Cell. 155: 497-9. PMID 24243007 DOI: 10.1016/j.cell.2013.09.039  0.76
2013 Rouzine IM, Weinberger LS. Reply to "Coadaptive stability of interfering particles with HIV-1 when there is an evolutionary conflict". Journal of Virology. 87: 9960-2. PMID 23943740 DOI: 10.1128/JVI.00932-13  0.76
2013 Gardner TJ, Bolovan-Fritts C, Teng MW, Redmann V, Kraus TA, Sperling R, Moran T, Britt W, Weinberger LS, Tortorella D. Development of a high-throughput assay to measure the neutralization capability of anti-cytomegalovirus antibodies. Clinical and Vaccine Immunology : Cvi. 20: 540-50. PMID 23389931 DOI: 10.1128/CVI.00644-12  0.76
2013 Boehm D, Calvanese V, Dar RD, Xing S, Schroeder S, Martins L, Aull K, Li PC, Planelles V, Bradner JE, Zhou MM, Siliciano RF, Weinberger L, Verdin E, Ott M. BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. Cell Cycle (Georgetown, Tex.). 12: 452-62. PMID 23255218 DOI: 10.4161/cc.23309  0.76
2013 Rouzine IM, Weinberger LS. Design requirements for interfering particles to maintain coadaptive stability with HIV-1. Journal of Virology. 87: 2081-93. PMID 23221552 DOI: 10.1128/JVI.02741-12  0.76
2013 Rouzine IM, Weinberger LS. The quantitative theory of within-host viral evolution Journal of Statistical Mechanics: Theory and Experiment. 2013. DOI: 10.1088/1742-5468/2013/01/P01009  0.76
2012 Teng MW, Bolovan-Fritts C, Dar RD, Womack A, Simpson ML, Shenk T, Weinberger LS. An endogenous accelerator for viral gene expression confers a fitness advantage. Cell. 151: 1569-80. PMID 23260143 DOI: 10.1016/j.cell.2012.11.051  0.4
2012 Dar RD, Razooky BS, Singh A, Trimeloni TV, McCollum JM, Cox CD, Simpson ML, Weinberger LS. Transcriptional burst frequency and burst size are equally modulated across the human genome. Proceedings of the National Academy of Sciences of the United States of America. 109: 17454-9. PMID 23064634 DOI: 10.1073/pnas.1213530109  1
2012 Razooky BS, Gutierrez E, Terry VH, Spina CA, Groisman A, Weinberger LS. Microwell devices with finger-like channels for long-term imaging of HIV-1 expression kinetics in primary human lymphocytes. Lab On a Chip. 12: 4305-12. PMID 22976503 DOI: 10.1039/c2lc40170c  1
2012 Singh A, Razooky BS, Dar RD, Weinberger LS. Dynamics of protein noise can distinguish between alternate sources of gene-expression variability. Molecular Systems Biology. 8: 607. PMID 22929617 DOI: 10.1038/msb.2012.38  1
2011 Franz K, Singh A, Weinberger LS. Lentiviral vectors to study stochastic noise in gene expression. Methods in Enzymology. 497: 603-22. PMID 21601105 DOI: 10.1016/B978-0-12-385075-1.00026-3  0.4
2011 Metzger VT, Lloyd-Smith JO, Weinberger LS. Autonomous targeting of infectious superspreaders using engineered transmissible therapies. Plos Computational Biology. 7: e1002015. PMID 21483468 DOI: 10.1371/journal.pcbi.1002015  0.76
2011 Razooky BS, Weinberger LS. Mapping the architecture of the HIV-1 Tat circuit: A decision-making circuit that lacks bistability and exploits stochastic noise. Methods (San Diego, Calif.). 53: 68-77. PMID 21167940 DOI: 10.1016/j.ymeth.2010.12.006  1
2010 Singh A, Razooky B, Cox CD, Simpson ML, Weinberger LS. Transcriptional bursting from the HIV-1 promoter is a significant source of stochastic noise in HIV-1 gene expression. Biophysical Journal. 98: L32-4. PMID 20409455 DOI: 10.1016/j.bpj.2010.03.001  0.4
2009 Weinberger AD, Perelson AS, Ribeiro RM, Weinberger LS. Accelerated immunodeficiency by anti-CCR5 treatment in HIV infection. Plos Computational Biology. 5: e1000467. PMID 19680436 DOI: 10.1371/journal.pcbi.1000467  0.76
2009 Singh A, Weinberger LS. Stochastic gene expression as a molecular switch for viral latency. Current Opinion in Microbiology. 12: 460-6. PMID 19595626 DOI: 10.1016/j.mib.2009.06.016  0.4
2008 Weinberger LS, Dar RD, Simpson ML. Transient-mediated fate determination in a transcriptional circuit of HIV. Nature Genetics. 40: 466-70. PMID 18344999 DOI: 10.1038/ng.116  0.4
2005 Weinberger LS, Burnett JC, Toettcher JE, Arkin AP, Schaffer DV. Stochastic gene expression in a lentiviral positive-feedback loop: HIV-1 Tat fluctuations drive phenotypic diversity. Cell. 122: 169-82. PMID 16051143 DOI: 10.1016/j.cell.2005.06.006  0.92
2005 Weinberger LS, Burnett JC, Toettcher JE, Arkin AP, Schaffer DV. Stochastic gene expression in a lentiviral positive feedback loop: HIV-1 tat fluctuations drive phenotypic diversity Aiche Annual Meeting, Conference Proceedings. 10416.  0.76
2003 Weinberger LS, Schaffer DV, Arkin AP. Theoretical design of a gene therapy to prevent AIDS but not human immunodeficiency virus type 1 infection. Journal of Virology. 77: 10028-36. PMID 12941913  0.92
2002 Rosen HR, Ribeiro RR, Weinberger L, Wolf S, Chung M, Gretch DR, Perelson AS. Early hepatitis C viral kinetics correlate with long-term outcome in patients receiving high dose induction followed by combination interferon and ribavirin therapy Journal of Hepatology. 37: 124-130. PMID 12076871 DOI: 10.1016/S0168-8278(02)00114-9  0.76
2001 Mohri H, Perelson AS, Tung K, Ribeiro RM, Ramratnam B, Markowitz M, Kost R, Hurley A, Weinberger L, Cesar D, Hellerstein MK, Ho DD. Increased turnover of T lymphocytes in HIV-1 infection and its reduction by antiretroviral therapy Journal of Experimental Medicine. 194: 1277-1287. PMID 11696593 DOI: 10.1084/jem.194.9.1277  0.76
2000 Shiratori Y, Perelson AS, Weinberger L, Imazeki F, Yokosuka O, Nakata R, Ihori M, Hirota K, Ono N, Kuroda H, Motojima T, Nishigaki M, Omata M. Different turnover rate of hepatitis C virus clearance by different treatment regimen using interferon-beta. Journal of Hepatology. 33: 313-22. PMID 10952250 DOI: 10.1016/S0168-8278(00)80373-6  0.76
1999 Jin X, Bauer DE, Tuttleton SE, Lewin S, Gettie A, Blanchard J, Irwin CE, Safrit JT, Mittler J, Weinberger L, Kostrikis LG, Zhang L, Perelson AS, Ho DD. Dramatic rise in plasma viremia after CD8+ T cell depletion in simian immunodeficiency virus-infected macaques Journal of Experimental Medicine. 189: 991-998. PMID 10075982 DOI: 10.1084/jem.189.6.991  0.76
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