| Year |
Citation |
Score |
| 2019 |
Liu X, Masoudi A, Kahsai AW, Huang LY, Pani B, Staus DP, Shim PJ, Hirata K, Simhal RK, Schwalb AM, Rambarat PK, Ahn S, Lefkowitz RJ, Kobilka B. Mechanism of βAR regulation by an intracellular positive allosteric modulator. Science (New York, N.Y.). 364: 1283-1287. PMID 31249059 DOI: 10.1126/science.aaw8981 |
0.6 |
|
| 2018 |
Kahsai AW, Pani B, Lefkowitz RJ. GPCR signaling: conformational activation of arrestins. Cell Research. PMID 30030517 DOI: 10.1038/s41422-018-0067-x |
0.6 |
|
| 2018 |
Ahn S, Pani B, Kahsai AW, Olsen EK, Husemoen G, Vestrgaard M, Jin L, Zhao S, Wingler LM, Rambarat PK, Simhal RK, Xu TT, Sun LD, Shim PJ, Staus DP, et al. Small Molecule Positive Allosteric Modulators of the β-Adrenoceptor Isolated from DNA Encoded Libraries. Molecular Pharmacology. PMID 29769246 DOI: 10.1124/mol.118.111948 |
0.6 |
|
| 2018 |
Meng K, Shim P, Wang Q, Zhao S, Gu T, Kahsai AW, Ahn S, Chen X. Design, synthesis, and functional assessment of Cmpd-15 derivatives as negative allosteric modulators for the β-adrenergic receptor. Bioorganic & Medicinal Chemistry. PMID 29588128 DOI: 10.1016/j.bmc.2018.03.023 |
0.4 |
|
| 2017 |
Liu X, Ahn S, Kahsai AW, Meng KC, Latorraca NR, Pani B, Venkatakrishnan AJ, Masoudi A, Weis WI, Dror RO, Chen X, Lefkowitz RJ, Kobilka BK. Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure. Nature. PMID 28813418 DOI: 10.1038/nature23652 |
0.6 |
|
| 2017 |
Cahill TJ, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J, et al. Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28223524 DOI: 10.1073/pnas.1701529114 |
0.6 |
|
| 2017 |
Ahn S, Kahsai AW, Pani B, Wang QT, Zhao S, Wall AL, Strachan RT, Staus DP, Wingler LM, Sun LD, Sinnaeve J, Choi M, Cho T, Xu TT, Hansen GM, et al. Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library. Proceedings of the National Academy of Sciences of the United States of America. PMID 28130548 DOI: 10.1073/pnas.1620645114 |
0.6 |
|
| 2016 |
Thomsen AR, Plouffe B, Cahill TJ, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, et al. GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling. Cell. PMID 27499021 DOI: 10.1016/j.cell.2016.07.004 |
0.6 |
|
| 2016 |
Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, et al. Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature. PMID 27409812 DOI: 10.1038/nature18636 |
0.52 |
|
| 2016 |
Kahsai AW, Wisler JW, Lee J, Ahn S, Cahill Iii TJ, Dennison SM, Staus DP, Thomsen AR, Anasti KM, Pani B, Wingler LM, Desai H, Bompiani KM, Strachan RT, Qin X, et al. Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor. Nature Chemical Biology. PMID 27398998 DOI: 10.1038/nchembio.2126 |
0.52 |
|
| 2014 |
Shukla AK, Westfield GH, Xiao K, Reis RI, Huang LY, Tripathi-Shukla P, Qian J, Li S, Blanc A, Oleskie AN, Dosey AM, Su M, Liang CR, Gu LL, Shan JM, ... ... Kahsai AW, et al. Visualization of arrestin recruitment by a G-protein-coupled receptor. Nature. 512: 218-22. PMID 25043026 DOI: 10.1038/nature13430 |
0.52 |
|
| 2014 |
Kahsai AW, Rajagopal S, Sun J, Xiao K. Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry. Nature Protocols. 9: 1301-19. PMID 24810039 DOI: 10.1038/nprot.2014.075 |
0.52 |
|
| 2013 |
Aristotelous T, Ahn S, Shukla AK, Gawron S, Sassano MF, Kahsai AW, Wingler LM, Zhu X, Tripathi-Shukla P, Huang XP, Riley J, Besnard J, Read KD, Roth BL, Gilbert IH, et al. Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor. Acs Medicinal Chemistry Letters. 4: 1005-1010. PMID 24454993 DOI: 10.1021/ml400312j |
0.52 |
|
| 2011 |
Kahsai AW, Xiao K, Rajagopal S, Ahn S, Shukla AK, Sun J, Oas TG, Lefkowitz RJ. Multiple ligand-specific conformations of the β2-adrenergic receptor. Nature Chemical Biology. 7: 692-700. PMID 21857662 DOI: 10.1038/nchembio.634 |
0.52 |
|
| 2010 |
Knecht DA, LaFleur RA, Kahsai AW, Argueta CE, Beshir AB, Fenteany G. Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics. Plos One. 5: e14039. PMID 21124831 DOI: 10.1371/journal.pone.0014039 |
0.52 |
|
| 2010 |
Kahsai AW, Zhu S, Fenteany G. G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells. Biochimica Et Biophysica Acta. 1803: 300-10. PMID 19913059 DOI: 10.1016/j.bbamcr.2009.11.002 |
0.96 |
|
| 2008 |
Kahsai AW, Cui J, Kaniskan HU, Garner PP, Fenteany G. Analogs of tetrahydroisoquinoline natural products that inhibit cell migration and target galectin-3 outside of its carbohydrate-binding site. The Journal of Biological Chemistry. 283: 24534-45. PMID 18556657 DOI: 10.1074/jbc.M800006200 |
0.52 |
|
| 2006 |
Kahsai AW, Zhu S, Wardrop DJ, Lane WS, Fenteany G. Quinocarmycin analog DX-52-1 inhibits cell migration and targets radixin, disrupting interactions of radixin with actin and CD44. Chemistry & Biology. 13: 973-83. PMID 16984887 DOI: 10.1016/j.chembiol.2006.07.011 |
0.52 |
|
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