Christopher J. Thibodeaux - Publications

2016- Chemistry McGill University, Montreal, QC, Canada 
biochemistry, biophysics, biosynthesis, natural products, post-translational modification

21 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Uggowitzer KA, Habibi Y, Wei W, Moitessier N, Thibodeaux CJ. Mutations in Dynamic Structural Elements Alter the Kinetics and Fidelity of the Multifunctional Class II Lanthipeptide Synthetase, HalM2. Biochemistry. PMID 33507068 DOI: 10.1021/acs.biochem.0c00919  0.32
2020 Habibi Y, Thibodeaux CJ. A Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) Platform for Investigating Peptide Biosynthetic Enzymes. Journal of Visualized Experiments : Jove. PMID 32420996 DOI: 10.3791/61053  0.32
2019 Habibi Y, Uggowitzer KA, Issak H, Thibodeaux CJ. Insights into the Dynamic Structural Properties of a Lanthipeptide Synthetase using Hydrogen-Deuterium Exchange Mass Spectrometry. Journal of the American Chemical Society. PMID 31449409 DOI: 10.1021/jacs.9b06020  0.32
2019 Thibodeaux CJ, Chang WC, Liu HW. Unraveling flavoenzyme reaction mechanisms using flavin analogues and linear free energy relationships. Methods in Enzymology. 620: 167-188. PMID 31072486 DOI: 10.1016/Bs.Mie.2019.03.010  1
2017 Thibodeaux CJ, Liu HW. The type II isopentenyl Diphosphate:Dimethylallyl diphosphate isomerase (IDI-2): A model for acid/base chemistry in flavoenzyme catalysis. Archives of Biochemistry and Biophysics. PMID 28577910 DOI: 10.1016/J.Abb.2017.05.017  1
2016 Thibodeaux CJ, Wagoner J, Yu Y, van der Donk WA. The Leader Peptide Establishes Dehydration Order, Promotes Efficiency, and Ensures Fidelity During Lacticin 481 Biosynthesis. Journal of the American Chemical Society. PMID 27123925 DOI: 10.1021/jacs.6b00163  1
2015 Ju KS, Gao J, Doroghazi JR, Wang KA, Thibodeaux CJ, Li S, Metzger E, Fudala J, Su J, Zhang JK, Lee J, Cioni JP, Evans BS, Hirota R, Labeda DP, et al. Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes. Proceedings of the National Academy of Sciences of the United States of America. PMID 26324907 DOI: 10.1073/Pnas.1500873112  1
2014 Thibodeaux CJ, Ha T, van der Donk WA. A price to pay for relaxed substrate specificity: a comparative kinetic analysis of the class II lanthipeptide synthetases ProcM and HalM2. Journal of the American Chemical Society. 136: 17513-29. PMID 25409537 DOI: 10.1021/Ja5089452  1
2012 Thibodeaux CJ, Van Der Donk WA. Converging on a mechanism for choline degradation Proceedings of the National Academy of Sciences of the United States of America. 109: 21184-21185. PMID 23243142 DOI: 10.1073/pnas.1219534110  1
2012 Sun HG, Ruszczycky MW, Chang WC, Thibodeaux CJ, Liu HW. Nucleophilic participation of reduced flavin coenzyme in mechanism of UDP-galactopyranose mutase. The Journal of Biological Chemistry. 287: 4602-8. PMID 22187430 DOI: 10.1074/jbc.M111.312538  1
2012 Calveras J, Thibodeaux CJ, Mansoorabadi SO, Liu HW. Stereochemical studies of the type II isopentenyl diphosphate-dimethylallyl diphosphate isomerase implicate the FMN coenzyme in substrate protonation. Chembiochem : a European Journal of Chemical Biology. 13: 42-6. PMID 22135039 DOI: 10.1002/cbic.201100694  1
2012 Thibodeaux CJ, Chang WC, Liu HW. Enzymatic chemistry of cyclopropane, epoxide, and aziridine biosynthesis. Chemical Reviews. 112: 1681-709. PMID 22017381 DOI: 10.1021/Cr200073D  1
2011 Thibodeaux CJ, Liu HW. Mechanistic studies of 1-aminocyclopropane-1-carboxylate deaminase: characterization of an unusual pyridoxal 5'-phosphate-dependent reaction. Biochemistry. 50: 1950-62. PMID 21244019 DOI: 10.1021/Bi101927S  1
2010 Thibodeaux CJ, Chang WC, Liu HW. Linear free energy relationships demonstrate a catalytic role for the flavin mononucleotide coenzyme of the type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase. Journal of the American Chemical Society. 132: 9994-6. PMID 20593767 DOI: 10.1021/ja104090m  1
2009 White-Phillip J, Thibodeaux CJ, Liu HW. Enzymatic synthesis of TDP-deoxysugars. Methods in Enzymology. 459: 521-44. PMID 19362653 DOI: 10.1016/S0076-6879(09)04621-7  1
2008 Thibodeaux CJ, Melançon CE, Liu HW. Natural-product sugar biosynthesis and enzymatic glycodiversification. Angewandte Chemie (International Ed. in English). 47: 9814-59. PMID 19058170 DOI: 10.1002/anie.200801204  1
2008 Thibodeaux CJ, Mansoorabadi SO, Kittleman W, Chang WC, Liu HW. Evidence for the involvement of acid/base chemistry in the reaction catalyzed by the type II isopentenyl diphosphate/dimethylallyl diphosphate isomerase from Staphylococcus aureus. Biochemistry. 47: 2547-58. PMID 18229948 DOI: 10.1021/bi701467g  1
2007 Kittleman W, Thibodeaux CJ, Liu YN, Zhang H, Liu HW. Characterization and mechanistic studies of type II isopentenyl diphosphate:dimethylallyl diphosphate isomerase from Staphylococcus aureus. Biochemistry. 46: 8401-13. PMID 17585782 DOI: 10.1021/Bi700286A  1
2007 Mansoorabadi SO, Thibodeaux CJ, Liu HW. The diverse roles of flavin coenzymes--nature's most versatile thespians. The Journal of Organic Chemistry. 72: 6329-42. PMID 17580897 DOI: 10.1021/jo0703092  1
2007 Thibodeaux CJ, Melançon CE, Liu HW. Unusual sugar biosynthesis and natural product glycodiversification. Nature. 446: 1008-16. PMID 17460661 DOI: 10.1038/nature05814  1
2006 Melançon CE, Thibodeaux CJ, Liu HW. Glyco-stripping and glyco-swapping. Acs Chemical Biology. 1: 499-504. PMID 17168536 DOI: 10.1021/cb600365q  1
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