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Shirin Doroudgar, Ph.D. - Publications

Affiliations: 
2012 Biology (Joint Doctoral SDSU) University of California, San Diego, La Jolla, CA 
Area:
General Biology, Molecular Biology, Cell Biology
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32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Hofmann C, Aghajani M, D Alcock C, Blackwood EA, Sandmann C, Herzog N, Groß J, Plate L, Wiseman RL, Kaufman RJ, Katus HA, Jakobi T, Völkers M, Glembotski CC, Doroudgar S. ATF6 protects against protein misfolding during cardiac hypertrophy. Journal of Molecular and Cellular Cardiology. 189: 12-24. PMID 38401179 DOI: 10.1016/j.yjmcc.2024.02.001  0.69
2023 Hofmann C, Löwenthal Z, Aghajani M, Kaufman RJ, Katus HA, Frey N, Glembotski CC, Völkers M, Doroudgar S. mTORC1 inhibition impairs activation of the unfolded protein response and induces cell death during ER stress in cardiomyocytes. American Journal of Physiology. Heart and Circulatory Physiology. PMID 37294892 DOI: 10.1152/ajpheart.00682.2022  0.702
2022 Fu F, Doroudgar S. IRE1/XBP1 and endoplasmic reticulum signaling - from basic to translational research for cardiovascular disease. Current Opinion in Physiology. 28. PMID 37207249 DOI: 10.1016/j.cophys.2022.100552  0.48
2021 Górska AA, Sandmann C, Riechert E, Hofmann C, Malovrh E, Varma E, Kmietczyk V, Ölschläger J, Jürgensen L, Kamuf-Schenk V, Stroh C, Furkel J, Konstandin MH, Sticht C, Boileau E, ... ... Doroudgar S, et al. Muscle-specific Cand2 is translationally upregulated by mTORC1 and promotes adverse cardiac remodeling. Embo Reports. e52170. PMID 34605609 DOI: 10.15252/embr.202052170  0.383
2021 Riechert E, Kmietczyk V, Stein F, Schwarzl T, Sekaran T, Jürgensen L, Kamuf-Schenk V, Varma E, Hofmann C, Rettel M, Gür K, Ölschläger J, Kühl F, Martin J, Ramirez-Pedraza M, ... ... Doroudgar S, et al. Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes. Cell Reports. 35: 109100. PMID 33979607 DOI: 10.1016/j.celrep.2021.109100  0.305
2020 Meyer BA, Doroudgar S. ER Stress-Induced Secretion of Proteins and Their Extracellular Functions in the Heart. Cells. 9. PMID 32927693 DOI: 10.3390/cells9092066  0.53
2020 Blackwood EA, Thuerauf DJ, Stastna M, Stephens H, Sand Z, Pentoney A, Azizi K, Jakobi T, Van Eyk JE, Katus HA, Glembotski CC, Doroudgar S. Proteomic analysis of the cardiac myocyte secretome reveals extracellular protective functions for the ER stress response. Journal of Molecular and Cellular Cardiology. PMID 32339566 DOI: 10.1016/J.Yjmcc.2020.04.012  0.74
2020 Arrieta A, Blackwood EA, Stauffer WT, Domingo MS, Bilal AS, Thuerauf DJ, Pentoney AN, Aivati C, Sarakki AV, Doroudgar S, Glembotski CC. Mesencephalic astrocyte-derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart. The Journal of Biological Chemistry. PMID 32327487 DOI: 10.1074/Jbc.Ra120.013345  0.742
2020 Sanlialp A, Schumacher D, Kiper L, Varma E, Riechert E, Ho TC, Hofmann C, Kmietczyk V, Zimmermann F, Dlugosz S, Wirth A, Gorska AA, Burghaus J, Camacho Londoño JE, Katus HA, ... Doroudgar S, et al. Saraf-dependent activation of mTORC1 regulates cardiac growth. Journal of Molecular and Cellular Cardiology. PMID 32173353 DOI: 10.1016/J.Yjmcc.2020.03.004  0.499
2019 Grund A, Szaroszyk M, Korf-Klingebiel M, Malek Mohammadi M, Trogisch FA, Schrameck U, Gigina A, Tiedje C, Gaestel M, Kraft T, Hegermann J, Batkai S, Thum T, Perrot A, Remedios CD, ... ... Doroudgar S, et al. TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation. Embo Molecular Medicine. e10018. PMID 31468715 DOI: 10.15252/Emmm.201810018  0.408
2019 Hofmann C, Katus HA, Doroudgar S. Protein Misfolding in Cardiac Disease. Circulation. 139: 2085-2088. PMID 31034286 DOI: 10.1161/Circulationaha.118.037417  0.449
2019 Blackwood EA, Hofmann C, Santo Domingo M, Bilal AS, Sarakki A, Stauffer W, Arrieta A, Thuerauf DJ, Kolkhorst FW, Müller OJ, Jakobi T, Dieterich C, Katus HA, Doroudgar S, Glembotski CC. ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb. Circulation Research. 124: 79-93. PMID 30582446 DOI: 10.1161/Circresaha.118.313854  0.723
2019 Stauffer WT, Blackwood EA, Azizi K, Stephens HN, Doroudgar S, Glembotski CC. Abstract 260: The ER Unfolded Protein Response Effector, ATF6, Reduces Fibrosis and Moderates Activation of Cardiac Fibroblasts Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.260  0.688
2018 Braumann S, Thottakara T, Stücker S, Reischmann-Düsener S, Krämer E, Groß J, Hirt MN, Doroudgar S, Carrier L, Friedrich FW. S100A4 as a Target of the E3-Ligase Asb2β and Its Effect on Engineered Heart Tissue. Frontiers in Physiology. 9: 1292. PMID 30283351 DOI: 10.3389/fphys.2018.01292  0.379
2018 Stauffer WT, Doroudgar S, Stephens HN, Blackwood EA, Glembotski CC. Abstract 479: The ER Unfolded Protein Response Effector, ATF6, Promotes Proliferation and Maintains Pluripotency in Cardiac Stem Cells Circulation Research. 123. DOI: 10.1161/Res.123.Suppl_1.479  0.646
2018 Arrieta A, Blackwood EA, Aivati C, Stauffer WT, Santo Domingo M, Bilal AS, Sarakki AV, Thuerauf DJ, Doroudgar S, Glembotski CC. Abstract 352: Manf, a Structurally Unique Redox-sensitive Chaperone, Restores Er-protein Folding in the Ischemic Heart Circulation Research. 123. DOI: 10.1161/Res.123.Suppl_1.352  0.717
2017 Arrieta A, Blackwood E, Stauffer WT, Domingo MS, Pentoney AN, Thuerauf DJ, Doroudgar S, Glembotski CC. MANF, a structurally unique redox-sensitive chaperone, restores ER-protein folding in the ischemic heart Journal of Molecular and Cellular Cardiology. 112: 165. DOI: 10.1016/J.Yjmcc.2017.07.102  0.696
2016 Jin JK, Blackwood EA, Azizi KM, Thuerauf DJ, Fahem AG, Hofmann C, Kaufman RJ, Doroudgar S, Glembotski CC. ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart. Circulation Research. PMID 27932512 DOI: 10.1161/Circresaha.116.310266  0.719
2016 Reynolds JO, Quick AP, Wang Q, Beavers DL, Philippen LE, Showell J, Barreto-Torres G, Thuerauf DJ, Doroudgar S, Glembotski CC, Wehrens XH. Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca(2+) release. International Journal of Cardiology. 225: 371-380. PMID 27760414 DOI: 10.1016/J.Ijcard.2016.10.021  0.616
2016 Doroudgar S, Quijada P, Konstandin M, Ilves K, Broughton K, Khalafalla FG, Casillas A, Nguyen K, Gude N, Toko H, Ornelas L, Thuerauf DJ, Glembotski CC, Sussman MA, Völkers M. S100A4 protects the myocardium against ischemic stress. Journal of Molecular and Cellular Cardiology. PMID 27721024 DOI: 10.1016/J.Yjmcc.2016.10.001  0.65
2015 Doroudgar S, Völkers M, Thuerauf DJ, Khan M, Mohsin S, Respress JL, Wang W, Gude N, Müller OJ, Wehrens XH, Sussman MA, Glembotski CC. Hrd1 and ER-Associated Protein Degradation, ERAD, Are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes. Circulation Research. 117: 536-46. PMID 26137860 DOI: 10.1161/Circresaha.115.306993  0.742
2014 Völkers M, Doroudgar S, Nguyen N, Konstandin MH, Quijada P, Din S, Ornelas L, Thuerauf DJ, Gude N, Friedrich K, Herzig S, Glembotski CC, Sussman MA. PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity. Embo Molecular Medicine. 6: 57-65. PMID 24408966 DOI: 10.1002/Emmm.201303183  0.545
2013 Völkers M, Konstandin MH, Doroudgar S, Toko H, Quijada P, Din S, Joyo A, Ornelas L, Samse K, Thuerauf DJ, Gude N, Glembotski CC, Sussman MA. Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage. Circulation. 128: 2132-44. PMID 24008870 DOI: 10.1161/Circulationaha.113.003638  0.602
2013 Völkers M, Toko H, Doroudgar S, Din S, Quijada P, Joyo AY, Ornelas L, Joyo E, Thuerauf DJ, Konstandin MH, Gude N, Glembotski CC, Sussman MA. Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1. Proceedings of the National Academy of Sciences of the United States of America. 110: 12661-6. PMID 23842089 DOI: 10.1073/Pnas.1301455110  0.633
2013 Toko H, Konstandin MH, Doroudgar S, Ormachea L, Joyo E, Joyo AY, Din S, Gude NA, Collins B, Völkers M, Thuerauf DJ, Glembotski CC, Chen CH, Lu KP, Müller OJ, et al. Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1. Circulation Research. 112: 1244-52. PMID 23487407 DOI: 10.1161/Circresaha.113.301084  0.639
2013 Doroudgar S, Glembotski CC. ATF6 [corrected] and thrombospondin 4: the dynamic duo of the adaptive endoplasmic reticulum stress response. Circulation Research. 112: 9-12. PMID 23287452 DOI: 10.1161/Circresaha.112.280560  0.742
2013 Doroudgar S, Glembotski CC. New concepts of endoplasmic reticulum function in the heart: programmed to conserve. Journal of Molecular and Cellular Cardiology. 55: 85-91. PMID 23085588 DOI: 10.1016/J.Yjmcc.2012.10.006  0.73
2012 Eletto D, Maganty A, Eletto D, Dersh D, Makarewich C, Biswas C, Paton JC, Paton AW, Doroudgar S, Glembotski CC, Argon Y. Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response. Journal of Cell Science. 125: 4865-75. PMID 22854046 DOI: 10.1242/jcs.108928  0.673
2012 Glembotski CC, Thuerauf DJ, Huang C, Vekich JA, Gottlieb RA, Doroudgar S. Mesencephalic astrocyte-derived neurotrophic factor protects the heart from ischemic damage and is selectively secreted upon sarco/endoplasmic reticulum calcium depletion. The Journal of Biological Chemistry. 287: 25893-904. PMID 22637475 DOI: 10.1074/Jbc.M112.356345  0.687
2012 Doroudgar S, Glembotski CC. Chapter 10 – Communication in the Heart: Cardiokines as Mediators of a Molecular Social Network Musclefundamental Biology and Mechanisms of Disease. 127-139. DOI: 10.1016/B978-0-12-381510-1.00010-7  0.551
2011 Doroudgar S, Glembotski CC. The cardiokine story unfolds: ischemic stress-induced protein secretion in the heart. Trends in Molecular Medicine. 17: 207-14. PMID 21277256 DOI: 10.1016/J.Molmed.2010.12.003  0.729
2009 Doroudgar S, Thuerauf DJ, Marcinko MC, Belmont PJ, Glembotski CC. Ischemia activates the ATF6 branch of the endoplasmic reticulum stress response. The Journal of Biological Chemistry. 284: 29735-45. PMID 19622751 DOI: 10.1074/Jbc.M109.018036  0.739
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