Anthony A. Kossiakoff - Publications

Affiliations: 
Biochemistry & Molecular Biology University of Chicago, Chicago, IL 
Area:
hormone-induced receptor activation and regulation of growth hormone
Website:
https://purdueproteins.wordpress.com/speakers-2/kossiakoff/

132 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Dutka P, Mukherjee S, Gao X, Kang Y, de Waal PW, Wang L, Zhuang Y, Melcher K, Zhang C, Xu HE, Kossiakoff AA. Development of "Plug and Play" Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM. Structure (London, England : 1993). PMID 31669042 DOI: 10.1016/j.str.2019.10.004  0.56
2018 Sun J, Paduch M, Kim SA, Kramer RM, Barrios AF, Lu V, Luke J, Usatyuk S, Kossiakoff AA, Tan S. Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2. Proceedings of the National Academy of Sciences of the United States of America. PMID 30224453 DOI: 10.1073/pnas.1805343115  0.8
2018 Kintzer AF, Green EM, Dominik PK, Bridges M, Armache JP, Deneka D, Kim SS, Hubbell W, Kossiakoff AA, Cheng Y, Stroud RM. Structural basis for activation of voltage sensor domains in an ion channel TPC1. Proceedings of the National Academy of Sciences of the United States of America. PMID 30190435 DOI: 10.1073/pnas.1805651115  0.76
2018 Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, ... ... Kossiakoff AA, et al. Publisher Correction: Cryo-EM structure of human rhodopsin bound to an inhibitory G protein. Nature. PMID 29930353 DOI: 10.1038/s41586-018-0302-0  0.56
2018 Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, ... ... Kossiakoff AA, et al. Cryo-EM structure of human rhodopsin bound to an inhibitory G protein. Nature. PMID 29899450 DOI: 10.1038/s41586-018-0215-y  0.56
2018 Kossiakoff AA, Mukherjee S, Horn JR. Reply to Kang and Brooks: Comment on the calculations in protein thermodynamics. The Journal of Biological Chemistry. 293: 5063. PMID 29626107 DOI: 10.1074/jbc.RL118.002471  0.56
2018 Zhang Z, Liang WG, Bailey LJ, Tan YZ, Wei H, Wang A, Farcasanu M, Woods VA, McCord LA, Lee D, Shang W, Deprez-Poulain R, Deprez B, Liu DR, Koide A, ... ... Kossiakoff AA, et al. Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme. Elife. 7. PMID 29596046 DOI: 10.7554/eLife.33572  0.36
2018 Mukherjee S, Griffin DH, Horn JR, Rizk SS, Nocula-Lugowska M, Malmqvist M, Kim SS, Kossiakoff AA. Engineered synthetic antibodies as probes to quantify the energetic contributions of ligand binding to conformational changes in proteins. The Journal of Biological Chemistry. PMID 29321208 DOI: 10.1074/jbc.RA117.000656  0.8
2017 Bailey LJ, Sheehy KM, Dominik PK, Liang V, Rui H, Clark M, Jaskolowski M, Kim Y, Deneka D, Tang WJ, Kossiakoff AA. Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination. Journal of Molecular Biology. PMID 29273204 DOI: 10.1016/j.jmb.2017.12.012  0.68
2017 Rizk SS, Mukherjee S, Koide A, Koide S, Kossiakoff AA. Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody. Scientific Reports. 7: 556. PMID 28373671 DOI: 10.1038/s41598-017-00728-1  0.8
2017 Paduch M, Kossiakoff AA. Generating Conformation and Complex-Specific Synthetic Antibodies. Methods in Molecular Biology (Clifton, N.J.). 1575: 93-119. PMID 28255876 DOI: 10.1007/978-1-4939-6857-2_6  0.8
2016 Galilee M, Britan-Rosich E, Griner SL, Uysal S, Baumgärtel V, Lamb DC, Kossiakoff AA, Kotler M, Stroud RM, Marx A, Alian A. The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical. Structure (London, England : 1993). PMID 27692964 DOI: 10.1016/j.str.2016.08.015  0.76
2016 Shao Y, Huang H, Qin D, Li NS, Koide A, Staley JP, Koide S, Kossiakoff AA, Piccirilli JA. Specific Recognition of a Single-stranded RNA Sequence by a Synthetic Antibody Fragment. Journal of Molecular Biology. PMID 27593161 DOI: 10.1016/j.jmb.2016.08.029  0.68
2015 Dominik PK, Borowska MT, Dalmas O, Kim SS, Perozo E, Keenan RJ, Kossiakoff AA. Conformational Chaperones for Structural Studies of Membrane Proteins Using Antibody Phage Display with Nanodiscs. Structure (London, England : 1993). PMID 26749445 DOI: 10.1016/j.str.2015.11.014  0.8
2015 Zhong N, Loppnau P, Seitova A, Ravichandran M, Fenner M, Jain H, Bhattacharya A, Hutchinson A, Paduch M, Lu V, Olszewski M, Kossiakoff AA, Dowdell E, Koide A, Koide S, et al. Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins. Plos One. 10: e0139695. PMID 26437229 DOI: 10.1371/journal.pone.0139695  0.68
2015 Stuwe T, Bley CJ, Thierbach K, Petrovic S, Schilbach S, Mayo DJ, Perriches T, Rundlet EJ, Jeon YE, Collins LN, Huber FM, Lin DH, Paduch M, Koide A, Lu V, ... ... Kossiakoff AA, et al. Architecture of the fungal nuclear pore inner ring complex. Science (New York, N.Y.). PMID 26316600 DOI: 10.1126/science.aac9176  0.68
2015 Hornsby M, Paduch M, Miersch S, Sääf A, Matsuguchi T, Lee B, Wypisniak K, Doak A, King D, Usatyuk S, Perry K, Lu V, Thomas W, Luke J, Goodman J, ... ... Kossiakoff A, et al. A High Through-put Platform for Recombinant Antibodies to Folded Proteins. Molecular & Cellular Proteomics : McP. PMID 26290498 DOI: 10.1074/mcp.O115.052209  0.8
2015 Borowska MT, Dominik PK, Anghel SA, Kossiakoff AA, Keenan RJ. A YidC-like Protein in the Archaeal Plasma Membrane. Structure (London, England : 1993). 23: 1715-24. PMID 26256539 DOI: 10.1016/j.str.2015.06.025  0.68
2015 Mukherjee S, Ura M, Hoey RJ, Kossiakoff AA. A New Versatile Immobilization Tag Based on the Ultra High Affinity and Reversibility of the Calmodulin-Calmodulin Binding Peptide Interaction. Journal of Molecular Biology. 427: 2707-25. PMID 26159704 DOI: 10.1016/j.jmb.2015.06.018  0.56
2015 Marcon E, Jain H, Bhattacharya A, Guo H, Phanse S, Pu S, Byram G, Collins BC, Dowdell E, Fenner M, Guo X, Hutchinson A, Kennedy JJ, Krastins B, Larsen B, ... ... Kossiakoff AA, et al. Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation. Nature Methods. PMID 26121405 DOI: 10.1038/nmeth.3472  0.8
2015 Nocula-Lugowska M, Lugowski M, Salgia R, Kossiakoff AA. Engineering synthetic antibody inhibitors specific for LD2 or LD4 motifs of paxillin. Journal of Molecular Biology. PMID 26087144 DOI: 10.1016/j.jmb.2015.06.004  0.8
2015 Dominik PK, Kossiakoff AA. Phage display selections for affinity reagents to membrane proteins in nanodiscs. Methods in Enzymology. 557: 219-45. PMID 25950967 DOI: 10.1016/bs.mie.2014.12.032  0.8
2015 Mateja A, Paduch M, Chang HY, Szydlowska A, Kossiakoff AA, Hegde RS, Keenan RJ. Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo. Science (New York, N.Y.). 347: 1152-5. PMID 25745174 DOI: 10.1126/science.1261671  0.8
2015 Stuwe T, Correia AR, Lin DH, Paduch M, Lu VT, Kossiakoff AA, Hoelz A. Nuclear pores. Architecture of the nuclear pore complex coat. Science (New York, N.Y.). 347: 1148-52. PMID 25745173 DOI: 10.1126/science.aaa4136  0.8
2015 Miersch S, Li Z, Hanna R, McLaughlin ME, Hornsby M, Matsuguchi T, Paduch M, Sääf A, Wells J, Koide S, Kossiakoff A, Sidhu SS. Scalable high throughput selection from phage-displayed synthetic antibody libraries. Journal of Visualized Experiments : Jove. 51492. PMID 25651360 DOI: 10.3791/51492  0.8
2015 Rizk SS, Kouadio JL, Szymborska A, Duguid EM, Mukherjee S, Zheng J, Clevenger CV, Kossiakoff AA. Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling. Cell Communication and Signaling : Ccs. 13: 1. PMID 25589173 DOI: 10.1186/s12964-014-0080-8  0.8
2015 Mukherjee S, Ura M, Hoey RJ, Kossiakoff AA. A New Versatile Immobilization Tag Based on the Ultra High Affinity and Reversibility of the Calmodulin-Calmodulin Binding Peptide Interaction Journal of Molecular Biology. DOI: 10.1016/j.jmb.2015.06.018  0.8
2014 Bailey LJ, Sheehy KM, Hoey RJ, Schaefer ZP, Ura M, Kossiakoff AA. Applications for an engineered Protein-G variant with a pH controllable affinity to antibody fragments. Journal of Immunological Methods. 415: 24-30. PMID 25450256 DOI: 10.1016/j.jim.2014.10.003  0.8
2014 Welch BD, Paduch M, Leser GP, Bergman Z, Kors CA, Paterson RG, Jardetzky TS, Kossiakoff AA, Lamb RA. Probing the functions of the paramyxovirus glycoproteins F and HN with a panel of synthetic antibodies. Journal of Virology. 88: 11713-25. PMID 25122782 DOI: 10.1128/JVI.01707-14  0.8
2014 Shukla AK, Westfield GH, Xiao K, Reis RI, Huang LY, Tripathi-Shukla P, Qian J, Li S, Blanc A, Oleskie AN, Dosey AM, Su M, Liang CR, Gu LL, Shan JM, ... ... Kossiakoff AA, et al. Visualization of arrestin recruitment by a G-protein-coupled receptor. Nature. 512: 218-22. PMID 25043026 DOI: 10.1038/nature13430  0.8
2014 Marcon E, Ni Z, Pu S, Turinsky AL, Trimble SS, Olsen JB, Silverman-Gavrila R, Silverman-Gavrila L, Phanse S, Guo H, Zhong G, Guo X, Young P, Bailey S, Roudeva D, ... ... Kossiakoff AA, et al. Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation. Cell Reports. 8: 297-310. PMID 24981860 DOI: 10.1016/j.celrep.2014.05.050  0.8
2014 Wells JA, Kossiakoff AA. Cell biology. New tricks for an old dimer. Science (New York, N.Y.). 344: 703-4. PMID 24833381 DOI: 10.1126/science.1254799  0.8
2014 Li Q, Wanderling S, Paduch M, Medovoy D, Singharoy A, McGreevy R, Villalba-Galea CA, Hulse RE, Roux B, Schulten K, Kossiakoff A, Perozo E. Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain. Nature Structural & Molecular Biology. 21: 244-52. PMID 24487958 DOI: 10.1038/nsmb.2768  0.8
2013 Shukla AK, Manglik A, Kruse AC, Xiao K, Reis RI, Tseng WC, Staus DP, Hilger D, Uysal S, Huang LY, Paduch M, Tripathi-Shukla P, Koide A, Koide S, Weis WI, ... Kossiakoff AA, et al. Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature. 497: 137-41. PMID 23604254 DOI: 10.1038/nature12120  0.8
2013 Paduch M, Koide A, Uysal S, Rizk SS, Koide S, Kossiakoff AA. Generating conformation-specific synthetic antibodies to trap proteins in selected functional states. Methods (San Diego, Calif.). 60: 3-14. PMID 23280336 DOI: 10.1016/j.ymeth.2012.12.010  0.8
2012 Rizk SS, Misiura A, Paduch M, Kossiakoff AA. Substance P derivatives as versatile tools for specific delivery of various types of biomolecular cargo. Bioconjugate Chemistry. 23: 42-6. PMID 22175275 DOI: 10.1021/bc200496e  0.8
2011 Uysal S, Cuello LG, Cortes DM, Koide S, Kossiakoff AA, Perozo E. Mechanism of activation gating in the full-length KcsA K+ channel. Proceedings of the National Academy of Sciences of the United States of America. 108: 11896-9. PMID 21730186 DOI: 10.1073/pnas.1105112108  0.8
2011 Colwill K, Gräslund S, Persson H, Jarvik NE, Wyrzucki A, Wojcik J, Koide A, Kossiakoff AA, Koide S, Sidhu S, Dyson MR, Pershad K, Pavlovic JD, Karatt-Vellatt A, Schofield DJ, et al. A roadmap to generate renewable protein binders to the human proteome Nature Methods. 8: 551-561. PMID 21572409 DOI: 10.1038/nmeth.1607  0.8
2011 Rizk SS, Paduch M, Heithaus JH, Duguid EM, Sandstrom A, Kossiakoff AA. Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins. Nature Structural & Molecular Biology. 18: 437-42. PMID 21378967 DOI: 10.1038/nsmb.2002  0.8
2011 Koldobskaya Y, Duguid EM, Shechner DM, Suslov NB, Ye J, Sidhu SS, Bartel DP, Koide S, Kossiakoff AA, Piccirilli JA. A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination. Nature Structural & Molecular Biology. 18: 100-6. PMID 21151117 DOI: 10.1038/nsmb.1945  0.8
2010 Brawley CM, Uysal S, Kossiakoff AA, Rock RS. Characterization of engineered actin binding proteins that control filament assembly and structure. Plos One. 5: e13960. PMID 21103060 DOI: 10.1371/journal.pone.0013960  0.8
2010 Kossiakoff AA, Rizk S. Keeping signaling in check. Structure (London, England : 1993). 18: 275-6. PMID 20223207 DOI: 10.1016/j.str.2010.02.004  0.8
2010 Kossiakoff AA, Clevenger CV. Growth hormone and prolactin family of hormones and receptors. the structural basis for receptor activation and regulation Handbook of Cell Signaling, 2/E. 1: 237-243. DOI: 10.1016/B978-0-12-374145-5.00036-X  0.8
2009 Bang D, Tereshko V, Kossiakoff AA, Kent SB. Role of a salt bridge in the model protein crambin explored by chemical protein synthesis: X-ray structure of a unique protein analogue, [V15A]crambin-alpha-carboxamide. Molecular Biosystems. 5: 750-6. PMID 19562114 DOI: 10.1039/b903610e  0.8
2009 Rizk SS, Luchniak A, Uysal S, Brawley CM, Rock RS, Kossiakoff AA. An engineered substance P variant for receptor-mediated delivery of synthetic antibodies into tumor cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 11011-5. PMID 19549879 DOI: 10.1073/pnas.0904907106  0.8
2009 Mandal K, Pentelute BL, Tereshko V, Thammavongsa V, Schneewind O, Kossiakoff AA, Kent SB. Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods. Protein Science : a Publication of the Protein Society. 18: 1146-54. PMID 19472324 DOI: 10.1002/pro.127  0.8
2009 Uysal S, Vásquez V, Tereshko V, Esaki K, Fellouse FA, Sidhu SS, Koide S, Perozo E, Kossiakoff A. Crystal structure of full-length KcsA in its closed conformation. Proceedings of the National Academy of Sciences of the United States of America. 106: 6644-9. PMID 19346472 DOI: 10.1073/pnas.0810663106  0.8
2009 Horn JR, Sosnick TR, Kossiakoff AA. Principal determinants leading to transition state formation of a protein-protein complex, orientation trumps side-chain interactions. Proceedings of the National Academy of Sciences of the United States of America. 106: 2559-64. PMID 19196954 DOI: 10.1073/pnas.0809800106  0.8
2009 Mandal K, Pentelute BL, Tereshko V, Kossiakoff AA, Kent SB. X-ray structure of native scorpion toxin BmBKTx1 by racemic protein crystallography using direct methods. Journal of the American Chemical Society. 131: 1362-3. PMID 19133782 DOI: 10.1021/ja8077973  0.8
2008 Kossiakoff AA, Koide S. Understanding mechanisms governing protein-protein interactions from synthetic binding interfaces. Current Opinion in Structural Biology. 18: 499-506. PMID 18638552 DOI: 10.1016/j.sbi.2008.06.004  0.8
2008 Pentelute BL, Gates ZP, Tereshko V, Dashnau JL, Vanderkooi JM, Kossiakoff AA, Kent SB. X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers. Journal of the American Chemical Society. 130: 9695-701. PMID 18598029 DOI: 10.1021/ja8013538  0.8
2008 Tereshko V, Uysal S, Koide A, Margalef K, Koide S, Kossiakoff AA. Toward chaperone-assisted crystallography: protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold. Protein Science : a Publication of the Protein Society. 17: 1175-87. PMID 18445622 DOI: 10.1110/ps.034892.108  0.8
2008 Ye JD, Tereshko V, Frederiksen JK, Koide A, Fellouse FA, Sidhu SS, Koide S, Kossiakoff AA, Piccirilli JA. Synthetic antibodies for specific recognition and crystallization of structured RNA. Proceedings of the National Academy of Sciences of the United States of America. 105: 82-7. PMID 18162543 DOI: 10.1073/pnas.0709082105  0.8
2008 Qiu Y, Zhang R, Binkowski TA, Tereshko V, Joachimiak A, Kossiakoff A. The 1.38 Å crystal structure of DmsD protein from Salmonella typhimurium, a proofreading chaperone on the Tat pathway Proteins: Structure, Function and Genetics. 71: 525-533. DOI: 10.1002/prot.21828  0.8
2007 Koide A, Tereshko V, Uysal S, Margalef K, Kossiakoff AA, Koide S. Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope. Journal of Molecular Biology. 373: 941-53. PMID 17888451 DOI: 10.1016/j.jmb.2007.08.027  0.8
2007 Fellouse FA, Esaki K, Birtalan S, Raptis D, Cancasci VJ, Koide A, Jhurani P, Vasser M, Wiesmann C, Kossiakoff AA, Koide S, Sidhu SS. High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries. Journal of Molecular Biology. 373: 924-40. PMID 17825836 DOI: 10.1016/j.jmb.2007.08.005  0.8
2007 Sidhu SS, Kossiakoff AA. Exploring and designing protein function with restricted diversity. Current Opinion in Chemical Biology. 11: 347-54. PMID 17500026 DOI: 10.1016/j.cbpa.2007.05.001  0.8
2006 Gerdts CJ, Tereshko V, Yadav MK, Dementieva I, Collart F, Joachimiak A, Stevens RC, Kuhn P, Kossiakoff A, Ismagilov RF. Time-controlled microfluidic seeding in nL-volume droplets to separate nucleation and growth stages of protein crystallization Angewandte Chemie - International Edition. 45: 8156-8160. PMID 17099920 DOI: 10.1002/anie.200602946  0.8
2006 Horn JR, Kraybill B, Petro EJ, Coales SJ, Morrow JA, Hamuro Y, Kossiakoff AA. The role of protein dynamics in increasing binding affinity for an engineered protein-protein interaction established by H/D exchange mass spectrometry. Biochemistry. 45: 8488-98. PMID 16834322 DOI: 10.1021/bi0604328  0.8
2006 Pál G, Kouadio JL, Artis DR, Kossiakoff AA, Sidhu SS. Comprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning. The Journal of Biological Chemistry. 281: 22378-85. PMID 16762925 DOI: 10.1074/jbc.M603826200  0.8
2006 Rizvi SA, Tereshko V, Kossiakoff AA, Kozmin SA. Structure of bistramide A-actin complex at a 1.35 angstroms resolution. Journal of the American Chemical Society. 128: 3882-3. PMID 16551075 DOI: 10.1021/ja058319c  0.8
2006 Walsh ST, Kossiakoff AA. Crystal structure and site 1 binding energetics of human placental lactogen. Journal of Molecular Biology. 358: 773-84. PMID 16546209 DOI: 10.1016/j.jmb.2006.02.038  0.8
2006 Bang D, Gribenko AV, Tereshko V, Kossiakoff AA, Kent SB, Makhatadze GI. Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis. Nature Chemical Biology. 2: 139-43. PMID 16446709 DOI: 10.1038/nchembio766  0.8
2006 Qiu Y, Tereshko V, Kim Y, Zhang R, Collart F, Yousef M, Kossiakoff A, Joachimink A. The crystal structure of Aq_328 from the hyperthermophilic bacteria Aquifex aeolicus shows an ancestral histone fold Proteins: Structure, Function and Genetics. 62: 8-16. PMID 16287087 DOI: 10.1002/prot.20590  0.8
2005 Pál G, Fong SY, Kossiakoff AA, Sidhu SS. Alternative views of functional protein binding epitopes obtained by combinatorial shotgun scanning mutagenesis. Protein Science : a Publication of the Protein Society. 14: 2405-13. PMID 16131663 DOI: 10.1110/ps.051519805  0.8
2005 Kouadio JL, Horn JR, Pal G, Kossiakoff AA. Shotgun alanine scanning shows that growth hormone can bind productively to its receptor through a drastically minimized interface. The Journal of Biological Chemistry. 280: 25524-32. PMID 15857837 DOI: 10.1074/jbc.M502167200  0.8
2005 Bang D, Makhatadze GI, Tereshko V, Kossiakoff AA, Kent SB. Total chemical synthesis and X-ray crystal structure of a protein diastereomer: [D-Gln 35]ubiquitin. Angewandte Chemie (International Ed. in English). 44: 3852-6. PMID 15834850 DOI: 10.1002/anie.200463040  0.8
2005 Pál G, Ultsch MH, Clark KP, Currell B, Kossiakoff AA, Sidhu SS. Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis. Journal of Molecular Biology. 347: 489-94. PMID 15755445 DOI: 10.1016/j.jmb.2005.01.040  0.8
2005 Gopal B, Madan LL, Betz SF, Kossiakoff AA. The crystal structure of a quercetin 2,3-dioxygenase from Bacillus subtilis suggests modulation of enzyme activity by a change in the metal ion at the active site(s). Biochemistry. 44: 193-201. PMID 15628860 DOI: 10.1021/bi0484421  0.8
2004 Walsh ST, Sylvester JE, Kossiakoff AA. The high- and low-affinity receptor binding sites of growth hormone are allosterically coupled. Proceedings of the National Academy of Sciences of the United States of America. 101: 17078-83. PMID 15563602 DOI: 10.1073/pnas.0403336101  0.8
2004 Kossiakoff AA. The structural basis for biological signaling, regulation, and specificity in the growth hormone-prolactin system of hormones and receptors. Advances in Protein Chemistry. 68: 147-69. PMID 15500861 DOI: 10.1016/S0065-3233(04)68005-3  0.8
2004 Bernat B, Sun M, Dwyer M, Feldkamp M, Kossiakoff AA. Dissecting the binding energy epitope of a high-affinity variant of human growth hormone: cooperative and additive effects from combining mutations from independently selected phage display mutagenesis libraries. Biochemistry. 43: 6076-84. PMID 15147191 DOI: 10.1021/bi036069b  0.8
2003 Pal G, Kossiakoff AA, Sidhu SS. The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity. Journal of Molecular Biology. 332: 195-204. PMID 12946357 DOI: 10.1016/S0022-2836(03)00898-2  0.8
2003 Walsh ST, Jevitts LM, Sylvester JE, Kossiakoff AA. Site2 binding energetics of the regulatory step of growth hormone-induced receptor homodimerization. Protein Science : a Publication of the Protein Society. 12: 1960-70. PMID 12930995 DOI: 10.1110/ps.03133903  0.8
2003 Pál G, Santamaria F, Kossiakoff AA, Lu W. The first semi-synthetic serine protease made by native chemical ligation. Protein Expression and Purification. 29: 185-92. PMID 12767808  0.8
2003 Bernat B, Pal G, Sun M, Kossiakoff AA. Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization. Proceedings of the National Academy of Sciences of the United States of America. 100: 952-7. PMID 12552121 DOI: 10.1073/pnas.0235023100  0.8
2003 Kossiakoff AA. Growth Hormone and IL-4 Families of Hormones and Receptors: The Structural Basis for Receptor Activation and Regulation Handbook of Cell Signaling. 1: 241-249. DOI: 10.1016/B978-012124546-7/50403-4  0.68
2002 Yi S, Bernat B, Pál G, Kossiakoff A, Li WH. Functional promiscuity of squirrel monkey growth hormone receptor toward both primate and nonprimate growth hormones Molecular Biology and Evolution. 19: 1083-1092. PMID 12082127  0.8
2002 Schiffer C, Ultsch M, Walsh S, Somers W, De Vos AM, Kossiakoff A. Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: Evidence for strong structural coupling between receptor binding sites Journal of Molecular Biology. 316: 277-289. PMID 11851338 DOI: 10.1006/jmbi.2001.5348  0.8
2001 Dwyer JJ, Dwyer MA, Kossiakoff AA. High affinity RNase S-peptide variants obtained by phage display have a novel "hot-spot" of binding energy. Biochemistry. 40: 13491-500. PMID 11695896 DOI: 10.1021/bi011703b  0.8
2001 Randal M, Kossiakoff AA. The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex. Structure (London, England : 1993). 9: 155-63. PMID 11250200 DOI: 10.1016/S0969-2126(01)00567-6  0.8
2000 Elkins PA, Christinger HW, Sandowski Y, Sakal E, Gertler A, de Vos AM, Kossiakoff AA. Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor. Nature Structural Biology. 7: 808-15. PMID 10966654 DOI: 10.1038/79047  0.8
2000 Dwyer MA, Lu W, Dwyer JJ, Kossiakoff AA. Biosynthetic phage display: a novel protein engineering tool combining chemical and genetic diversity. Chemistry & Biology. 7: 263-74. PMID 10780926 DOI: 10.1016/S1074-5521(00)00102-2  0.8
2000 Lu WY, Starovasnik MA, Dwyer JJ, Kossiakoff AA, Kent SB, Lu W. Deciphering the role of the electrostatic interactions involving Gly70 in eglin C by total chemical protein synthesis. Biochemistry. 39: 3575-84. PMID 10736156 DOI: 10.1021/bi992292q  0.8
2000 Randal M, Kossiakoff AA. The 2.0 A structure of bovine interferon-gamma; assessment of the structural differences between species. Acta Crystallographica. Section D, Biological Crystallography. 56: 14-24. PMID 10666622  0.8
2000 Randal M, Kossiakoff AA. The 2.0 Å structure of bovine interferon-γ; assessment of the structural differences between species Acta Crystallographica Section D: Biological Crystallography. 56: 14-24. DOI: 10.1107/S0907444999014304  0.8
1999 Lu W, Randal M, Kossiakoff A, Kent SB. Probing intermolecular backbone H-bonding in serine proteinase-protein inhibitor complexes. Chemistry & Biology. 6: 419-27. PMID 10381402 DOI: 10.1016/S1074-5521(99)80060-X  0.8
1998 Christinger HW, Elkins PA, Sandowski Y, Sakal E, Gertler A, Kossiakoff AA, de Vos AM. Crystallization of ovine placental lactogen in a 1:2 complex with the extracellular domain of the rat prolactin receptor. Acta Crystallographica. Section D, Biological Crystallography. 54: 1408-11. PMID 10089521  0.8
1998 Kossiakoff AA, De Vos AM. Structural basis for cytokine hormone-receptor recognition and receptor activation. Advances in Protein Chemistry. 52: 67-108. PMID 9917918  0.8
1998 Randal M, Kossiakoff AA. Crystallization and preliminary X-ray analysis of a 1:1 complex between a designed monomeric interferon-gamma and its soluble receptor. Protein Science : a Publication of the Protein Society. 7: 1057-60. PMID 9568913 DOI: 10.1002/pro.5560070424  0.8
1997 Scheidig AJ, Hynes TR, Pelletier LA, Wells JA, Kossiakoff AA. Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities. Protein Science : a Publication of the Protein Society. 6: 1806-24. PMID 9300481 DOI: 10.1002/pro.5560060902  0.8
1996 McDowell RS, Kossiakoff AA. Hydroxyl and water molecule orientations in trypsin: comparison to molecular dynamic structures. Basic Life Sciences. 64: 273-87. PMID 9092457  0.8
1995 Kossiakoff AA. Structure of the growth hormone-receptor complex and mechanism of receptor signaling. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 36: 14S-16S. PMID 7769459  0.8
1995 McDowell RS, Kossiakoff AA. A comparison of neutron diffraction and molecular dynamics structures: hydroxyl group and water molecule orientations in trypsin. Journal of Molecular Biology. 250: 553-70. PMID 7616573 DOI: 10.1006/jmbi.1995.0397  0.8
1994 Ultsch MH, Somers W, Kossiakoff AA, de Vos AM. The crystal structure of affinity-matured human growth hormone at 2 A resolution. Journal of Molecular Biology. 236: 286-99. PMID 8107110 DOI: 10.1006/jmbi.1994.1135  0.8
1994 Somers W, Ultsch M, De Vos AM, Kossiakoff AA. The X-ray structure of a growth hormone-prolactin receptor complex. Nature. 372: 478-81. PMID 7984244 DOI: 10.1038/372478a0  0.8
1994 Kossiakoff AA, Somers W, Ultsch M, Andow K, Muller YA, De Vos AM. Comparison of the intermediate complexes of human growth hormone bound to the human growth hormone and prolactin receptors. Protein Science : a Publication of the Protein Society. 3: 1697-705. PMID 7849586 DOI: 10.1002/pro.5560031008  0.8
1994 Gamble TR, Clauser KR, Kossiakoff AA. The production and X-ray structure determination of perdeuterated Staphylococcal nuclease. Biophysical Chemistry. 53: 15-25. PMID 7841330 DOI: 10.1016/0301-4622(94)00072-7  0.8
1993 Kossiakoff AA, Hynes T, de Vos A. Molecular recognition in biological systems: from activation to inhibition. Biochemical Society Transactions. 21: 614-8. PMID 8224476  0.8
1993 Eigenbrot C, Randal M, Presta L, Carter P, Kossiakoff AA. X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling. Journal of Molecular Biology. 229: 969-95. PMID 8095303 DOI: 10.1006/jmbi.1993.1099  0.8
1993 Kossiakoff A, Smith M. Protein engineering Current Opinion in Biotechnology. 4: 381-384. DOI: 10.1016/0958-1669(93)90001-D  0.8
1992 Kossiakoff AA, Sintchak MD, Shpungin J, Presta LG. Analysis of solvent structure in proteins using neutron D2O-H2O solvent maps: pattern of primary and secondary hydration of trypsin. Proteins. 12: 223-36. PMID 1557350 DOI: 10.1002/prot.340120303  0.8
1992 Finer-Moore JS, Kossiakoff AA, Hurley JH, Earnest T, Stroud RM. Solvent structure in crystals of trypsin determined by X-ray and neutron diffraction. Proteins. 12: 203-22. PMID 1557349 DOI: 10.1002/prot.340120302  0.8
1992 de Vos AM, Ultsch M, Kossiakoff AA. Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science (New York, N.Y.). 255: 306-12. PMID 1549776  0.8
1992 Eigenbrot C, Randal M, Kossiakoff AA. Structural effects induced by mutagenesis affected by crystal packing factors: the structure of a 30-51 disulfide mutant of basic pancreatic trypsin inhibitor. Proteins. 14: 75-87. PMID 1384034 DOI: 10.1002/prot.340140109  0.8
1992 Kossiakoff AA, Randal M, Guenot J, Eigenbrot C. Variability of conformations at crystal contacts in BPTI represent true low-energy structures: correspondence among lattice packing and molecular dynamics structures. Proteins. 14: 65-74. PMID 1384033 DOI: 10.1002/prot.340140108  0.8
1992 Eigenbrot C, Kossiakoff AA. Structural consequences of mutation. Current Opinion in Biotechnology. 3: 333-7. PMID 1368433 DOI: 10.1016/0958-1669(92)90160-K  0.8
1992 de Vos AM, Ultsch MH, Kelley RF, Padmanabhan K, Tulinsky A, Westbrook ML, Kossiakoff AA. Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution. Biochemistry. 31: 270-9. PMID 1310033  0.8
1992 de Vos AM, Kossiakoff AA. Receptor action and interaction Current Opinion in Structural Biology. 2: 852-858. DOI: 10.1016/0959-440X(92)90111-J  0.8
1991 Kossiakoff AA, Ultsch M, White S, Eigenbrot C. Neutron structure of subtilisin BPN': effects of chemical environment on hydrogen-bonding geometries and the pattern of hydrogen-deuterium exchange in secondary structure elements. Biochemistry. 30: 1211-21. PMID 1991100  0.8
1991 Ultsch M, de Vos AM, Kossiakoff AA. Crystals of the complex between human growth hormone and the extracellular domain of its receptor. Journal of Molecular Biology. 222: 865-8. PMID 1762154 DOI: 10.1016/0022-2836(91)90578-T  0.8
1991 Eigenbrot C, Randal M, Quan C, Burnier J, O'Connell L, Rinderknecht E, Kossiakoff AA. X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants. Journal of Molecular Biology. 221: 15-21. PMID 1656049 DOI: 10.1016/0022-2836(91)80196-2  0.8
1990 Kossiakoff AA, Shpungin J, Sintchak MD. Hydroxyl hydrogen conformations in trypsin determined by the neutron diffraction solvent difference map method: relative importance of steric and electrostatic factors in defining hydrogen-bonding geometries. Proceedings of the National Academy of Sciences of the United States of America. 87: 4468-72. PMID 2352930 DOI: 10.1073/pnas.87.12.4468  0.8
1990 Katz B, Kossiakoff AA. Crystal structures of subtilisin BPN' variants containing disulfide bonds and cavities: concerted structural rearrangements induced by mutagenesis. Proteins. 7: 343-57. PMID 2199972 DOI: 10.1002/prot.340070406  0.8
1990 Hynes TR, Randal M, Kennedy LA, Eigenbrot C, Kossiakoff AA. X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor. Biochemistry. 29: 10018-22. PMID 2125487  0.8
1990 Eigenbrot C, Randal M, Kossiakoff AA. Structural effects induced by removal of a disulfide-bridge: the X-ray structure of the C30A/C51A mutant of basic pancreatic trypsin inhibitor at 1.6 A. Protein Engineering. 3: 591-8. PMID 1699222 DOI: 10.1093/protein/3.7.591  0.8
1988 Kossiakoff AA. Tertiary structure is a principal determinant to protein deamidation. Science (New York, N.Y.). 240: 191-4. PMID 3353715  0.8
1988 Bott R, Ultsch M, Kossiakoff A, Graycar T, Katz B, Power S. The three-dimensional structure of Bacillus amyloliquefaciens subtilisin at 1.8 A and an analysis of the structural consequences of peroxide inactivation Journal of Biological Chemistry. 263: 7895-7906. PMID 3286644  0.8
1988 Kossiakoff AA. The use of neutrons to show how proteins work. Basic Life Sciences. 46: 63-78. PMID 3066338  0.8
1986 Kossiakoff AA. Protein dynamics investigated by neutron diffraction. Methods in Enzymology. 131: 433-47. PMID 3773769  0.8
1986 Katz BA, Kossiakoff A. The crystallographically determined structures of atypical strained disulfides engineered into subtilisin Journal of Biological Chemistry. 261: 15480-15485. PMID 3096989  0.8
1986 Shpungin J, Kossiakoff AA. A method of solvent structure analysis for proteins using D2O-H2O neutron difference maps. Methods in Enzymology. 127: 329-42. PMID 3016462 DOI: 10.1016/0076-6879(86)27027-5  0.8
1985 Kossiakoff AA. The application of neutron crystallography to the study of dynamic and and hydration properties of proteins. Annual Review of Biochemistry. 54: 1195-227. PMID 3896118 DOI: 10.1146/annurev.bi.54.070185.005555  0.8
1985 Kossiakoff AA, Spencer SA. [32] Automated peak fitting procedure for processing data from an area detector and its application to the neutron structure of trypsin Methods in Enzymology. 114: 530-551. DOI: 10.1016/0076-6879(85)14034-6  0.8
1984 Kossiakoff AA. Use of the neutron diffraction--H/D exchange technique to determine the conformational dynamics of trypsin. Basic Life Sciences. 27: 281-304. PMID 6712567  0.8
1984 Kossiakoff AA, Shteyn S. Effect of protein packing structure on side-chain methyl rotor conformations. Nature. 311: 582-3. PMID 6548296 DOI: 10.1038/311582a0  0.8
1983 Kossiakoff AA. Neutron protein crystallography: advances in methods and applications. Annual Review of Biophysics and Bioengineering. 12: 159-82. PMID 6347037 DOI: 10.1146/annurev.bb.12.060183.001111  0.8
1982 Kossiakoff AA. Protein dynamics investigated by the neutron diffraction-hydrogen exchange technique. Nature. 296: 713-21. PMID 7070514 DOI: 10.1038/296713a0  0.8
1981 Kossiakoff AA, Spencer SA. Direct determination of the protonation states of aspartic acid-102 and histidine-57 in the tetrahedral intermediate of the serine proteases: neutron structure of trypsin. Biochemistry. 20: 6462-74. PMID 7030393  0.8
1980 Kossiakoff AA, Spencer SA. Neutron diffraction identifies His 57 as the catalytic base in trypsin. Nature. 288: 414-6. PMID 7432541 DOI: 10.1038/288414a0  0.8
1977 Kossiakoff AA, Chambers JL, Kay LM, Stroud RM. Structure of bovine trypsinogen at 1.9 A resolution. Biochemistry. 16: 654-64. PMID 556951  0.8
1977 Stroud RM, Kossiakoff AA, Chambers JL. Mechanisms of zymogen activation. Annual Review of Biophysics and Bioengineering. 6: 177-93. PMID 17350 DOI: 10.1146/annurev.bb.06.060177.001141  0.8
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