Irfan Rahman - Publications

Affiliations: 
University of Rochester, Rochester, NY 
Area:
Toxicology, Biochemistry, Molecular Biology
Website:
https://www.urmc.rochester.edu/people/23899711-irfan-rahman

212 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Wang Q, Sundar IK, Blum JL, Ratner JR, Lucas JH, Chuang TD, Wang Y, Liu J, Rehan VK, Zelikoff JT, Rahman I. Prenatal Exposure to E-Cigarette Aerosols Leads to Sex-dependent Pulmonary Extracellular Matrix Remodeling and Myogenesis in Offspring Mice. American Journal of Respiratory Cell and Molecular Biology. PMID 32853043 DOI: 10.1165/rcmb.2020-0036OC  1
2020 Fong G, Gayen Nee' Betal S, Murthy S, Favara M, Chan JSY, Addya S, Shaffer TH, Greenspan J, Bhandari V, Li D, Rahman I, Aghai ZH. DNA Methylation Profile in Human Cord Blood Mononuclear Leukocytes From Term Neonates: Effects of Histological Chorioamnionitis. Frontiers in Pediatrics. 8: 437. PMID 32850550 DOI: 10.3389/fped.2020.00437  1
2020 Maremanda KP, Sundar IK, Li D, Rahman I. Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis. Research Square. PMID 32702724 DOI: 10.21203/rs.3.rs-35347/v1  1
2020 Wang Q, Sundar I, Li D, Lucas J, Muthumalage T, McDonough S, Rahman I. E-cigarette-Induced Pulmonary Inflammation and Dysregulated Repair are Mediated by nAChR α7 Receptor: Role of nAChR α7 in ACE2 Covid-19 receptor regulation. Research Square. PMID 32702718 DOI: 10.21203/rs.2.23829/v2  1
2020 Li D, Shi H, Xie Z, Rahman I, McIntosh S, Bansal-Travers M, Winickoff JP, Drehmer JE, Ossip DJ. Home smoking and vaping policies among US adults: results from the Population Assessment of Tobacco and Health (PATH) study, wave 3. Preventive Medicine. 106215. PMID 32693178 DOI: 10.1016/j.ypmed.2020.106215  1
2020 Muthumalage T, Lucas JH, Wang Q, Lamb T, McGraw MD, Rahman I. Pulmonary Toxicity and Inflammatory Response of E-Cigarette Vape Cartridges Containing Medium-Chain Triglycerides Oil and Vitamin E Acetate: Implications in the Pathogenesis of EVALI. Toxics. 8. PMID 32605182 DOI: 10.3390/toxics8030046  1
2020 Maremanda KP, Sundar IK, Li D, Rahman I. Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis. Medrxiv : the Preprint Server For Health Sciences. PMID 32587985 DOI: 10.1101/2020.06.14.20129957  1
2020 Muthumalage T, Lucas JH, Wang Q, Lamb T, McGraw MD, Rahman I. Pulmonary toxicity and inflammatory response of e-cigarettes containing medium-chain triglyceride oil and vitamin E acetate: Implications in the pathogenesis of EVALI but independent of SARS-COV-2 COVID-19 related proteins. Biorxiv : the Preprint Server For Biology. PMID 32587960 DOI: 10.1101/2020.06.14.151381  1
2020 Wang Q, Sundar IK, Li D, Lucas JH, Muthumalage T, McDonough SR, Rahman I. E-cigarette-induced pulmonary inflammation and dysregulated repair are mediated by nAChR α7 receptor: role of nAChR α7 in SARS-CoV-2 Covid-19 ACE2 receptor regulation. Respiratory Research. 21: 154. PMID 32552811 DOI: 10.1186/s12931-020-01396-y  1
2020 Kaur G, Lungarella G, Rahman I. SARS-CoV-2 COVID-19 susceptibility and lung inflammatory storm by smoking and vaping. Journal of Inflammation (London, England). 17: 21. PMID 32528233 DOI: 10.1186/s12950-020-00250-8  1
2020 Muthumalage T, Friedman MR, McGraw MD, Ginsberg G, Friedman AE, Rahman I. Chemical Constituents Involved in E-Cigarette, or Vaping Product Use-Associated Lung Injury (EVALI). Toxics. 8. PMID 32260052 DOI: 10.3390/toxics8020025  1
2020 Manevski M, Muthumalage T, Devadoss D, Sundar IK, Wang Q, Singh KP, Unwalla HJ, Chand HS, Rahman I. Cellular stress responses and dysfunctional Mitochondrial-cellular senescence, and therapeutics in chronic respiratory diseases. Redox Biology. 101443. PMID 32037306 DOI: 10.1016/j.redox.2020.101443  1
2019 Chand HS, Muthumalage T, Maziak W, Rahman I. Pulmonary Toxicity and the Pathophysiology of Electronic Cigarette, or Vaping Product, Use Associated Lung Injury. Frontiers in Pharmacology. 10: 1619. PMID 31992985 DOI: 10.3389/fphar.2019.01619  1
2019 Singh KP, Lawyer G, Muthumalage T, Maremanda KP, Khan NA, McDonough SR, Ye D, McIntosh S, Rahman I. Systemic biomarkers in electronic cigarette users: implications for noninvasive assessment of vaping-associated pulmonary injuries. Erj Open Research. 5. PMID 31886159 DOI: 10.1183/23120541.00182-2019  1
2019 Muthumalage T, Lamb T, Friedman MR, Rahman I. E-cigarette flavored pods induce inflammation, epithelial barrier dysfunction, and DNA damage in lung epithelial cells and monocytes. Scientific Reports. 9: 19035. PMID 31836726 DOI: 10.1038/s41598-019-51643-6  1
2019 Xie Z, Ossip DJ, Rahman I, Li D. Use of electronic cigarettes and self-reported COPD diagnosis in adults. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 31830263 DOI: 10.1093/ntr/ntz234  1
2019 Lawyer GR, Jackson M, Prinz M, Lamb T, Wang Q, Muthumalage T, Rahman I. Classification of flavors in cigarillos and little cigars and their variable cellular and acellular oxidative and cytotoxic responses. Plos One. 14: e0226066. PMID 31825984 DOI: 10.1371/journal.pone.0226066  1
2019 Wang Q, Khan NA, Muthumalage T, Lawyer GR, McDonough SR, Chuang TD, Gong M, Sundar IK, Rehan VK, Rahman I. Dysregulated repair and inflammatory responses by e-cigarette-derived inhaled nicotine and humectant propylene glycol in a sex-dependent manner in mouse lung. Faseb Bioadvances. 1: 609-623. PMID 31825014 DOI: 10.1096/fba.2019-00048  1
2019 Sundar IK, Li D, Rahman I. Small RNA-sequence analysis of plasma-derived extracellular vesicle miRNAs in smokers and patients with chronic obstructive pulmonary disease as circulating biomarkers. Journal of Extracellular Vesicles. 8: 1684816. PMID 31762962 DOI: 10.1080/20013078.2019.1684816  1
2019 Maremanda KP, Sundar IK, Rahman I. Protective role of mesenchymal stem cells and mesenchymal stem cell-derived exosomes in cigarette smoke-induced mitochondrial dysfunction in mice. Toxicology and Applied Pharmacology. 114788. PMID 31678243 DOI: 10.1016/j.taap.2019.114788  1
2019 Sundar IK, Maremanda KP, Rahman I. Mitochondrial dysfunction is associated with Miro1 reduction in lung epithelial cells by cigarette smoke. Toxicology Letters. PMID 31593750 DOI: 10.1016/j.toxlet.2019.09.022  1
2019 Muthumalage T, Rahman I. Cannabidiol differentially regulates basal and LPS-induced inflammatory responses in macrophages, lung epithelial cells, and fibroblasts. Toxicology and Applied Pharmacology. 114713. PMID 31437494 DOI: 10.1016/j.taap.2019.114713  1
2019 Javed F, Rahman I, Romanos GE. Tobacco-product usage as a risk factor for dental implants. Periodontology 2000. 81: 48-56. PMID 31407428 DOI: 10.1111/prd.12282  1
2019 BinShabaib M, ALHarthi SS, Akram Z, Khan J, Rahman I, Romanos GE, Javed F. Clinical periodontal status and gingival crevicular fluid cytokine profile among cigarette-smokers, electronic-cigarette users and never-smokers. Archives of Oral Biology. 102: 212-217. PMID 31078071 DOI: 10.1016/j.archoralbio.2019.05.001  1
2019 Gayen Nee' Betal S, Murthy S, Favara M, Fong G, Chan JSY, Addya S, Shaffer TH, Greenspan J, Bhandari V, Rahman I, Aghai ZH. Histological Chorioamnionitis Induces Differential Gene Expression in Human Cord Blood Mononuclear Leukocytes from Term Neonates. Scientific Reports. 9: 5862. PMID 30971730 DOI: 10.1038/s41598-019-42205-x  1
2019 Khan NA, Yogeswaran S, Wang Q, Muthumalage T, Sundar IK, Rahman I. Waterpipe smoke and e-cigarette vapor differentially affect circadian molecular clock gene expression in mouse lungs. Plos One. 14: e0211645. PMID 30811401 DOI: 10.1371/journal.pone.0211645  1
2019 Li D, Sundar IK, McIntosh S, Ossip DJ, Goniewicz ML, O'Connor RJ, Rahman I. Association of smoking and electronic cigarette use with wheezing and related respiratory symptoms in adults: cross-sectional results from the Population Assessment of Tobacco and Health (PATH) study, wave 2. Tobacco Control. PMID 30760629 DOI: 10.1136/tobaccocontrol-2018-054694  1
2018 Schneller LM, McIntosh S, Li D, Rahman I, Ossip D, Goniewicz M, O'Connor RJ. Tobacco use and chemosensory impairments among current adult tobacco users in the US: Data from NHANES 2013-2014. Tobacco Induced Diseases. 16: 43. PMID 31516441 DOI: 10.18332/tid/94202  1
2018 ALHarthi SS, BinShabaib M, Akram Z, Rahman I, Romanos GE, Javed F. Impact of cigarette smoking and vaping on the outcome of full-mouth ultrasonic scaling among patients with gingival inflammation: a prospective study. Clinical Oral Investigations. PMID 30361795 DOI: 10.1007/s00784-018-2725-2  1
2018 Lee H, Lee J, Hong SH, Rahman I, Yang SR. Inhibition of RAGE Attenuates Cigarette Smoke-Induced Lung Epithelial Cell Damage via RAGE-Mediated Nrf2/DAMP Signaling. Frontiers in Pharmacology. 9: 684. PMID 30013476 DOI: 10.3389/fphar.2018.00684  1
2018 Paquette ST, Dawes RP, Sundar IK, Rahman I, Brown EB, White PM. Chronic cigarette smoke exposure drives spiral ganglion neuron loss in mice. Scientific Reports. 8: 5746. PMID 29636532 DOI: 10.1038/s41598-018-24166-9  1
2018 Sundar IK, Rashid K, Gerloff J, Rangel-Moreno J, Li D, Rahman I. Genetic ablation of histone deacetylase 2 leads to lung cellular senescence and lymphoid follicle formation in COPD/emphysema. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201701518R. PMID 29630406 DOI: 10.1096/fj.201701518R  1
2018 Kaur G, Muthumalage T, Rahman I. Mechanisms of toxicity and biomarkers of flavoring and flavor enhancing chemicals in emerging tobacco and non-tobacco products. Toxicology Letters. PMID 29481849 DOI: 10.1016/j.toxlet.2018.02.025  1
2018 Sundar IK, Rashid K, Gerloff J, Li D, Rahman I. Genetic Ablation of p16(Ink4a) Does Not Protect Against Cellular Senescence in Mouse Models of COPD/Emphysema. American Journal of Respiratory Cell and Molecular Biology. PMID 29447461 DOI: 10.1165/rcmb.2017-0390OC  1
2018 Eddingsaas N, Pagano T, Cummings C, Rahman I, Robinson R, Hensel E. Qualitative Analysis of E-Liquid Emissions as a Function of Flavor Additives Using Two Aerosol Capture Methods. International Journal of Environmental Research and Public Health. 15. PMID 29438289 DOI: 10.3390/ijerph15020323  1
2018 Khan NA, Sundar IK, Rahman I. Strain- and sex-dependent pulmonary toxicity of waterpipe smoke in mouse. Physiological Reports. 6. PMID 29417753 DOI: 10.14814/phy2.13579  1
2017 Muthumalage T, Prinz M, Ansah KO, Gerloff J, Sundar IK, Rahman I. Inflammatory and Oxidative Responses Induced by Exposure to Commonly Used e-Cigarette Flavoring Chemicals and Flavored e-Liquids without Nicotine. Frontiers in Physiology. 8: 1130. PMID 29375399 DOI: 10.3389/fphys.2017.01130  1
2017 Javed F, Kellesarian SV, Abduljabbar T, Abduljabbar AT, Akram Z, Vohra F, Rahman I, Romanos GE. Influence of involuntary cigarette smoke inhalation on osseointegration: a systematic review and meta-analysis of preclinical studies. International Journal of Oral and Maxillofacial Surgery. PMID 29233582 DOI: 10.1016/j.ijom.2017.11.009  1
2017 Sundar IK, Sellix MT, Rahman I. Redox Regulation of Circadian Molecular Clock in Chronic Airway Diseases. Free Radical Biology & Medicine. PMID 29097215 DOI: 10.1016/j.freeradbiomed.2017.10.383  1
2017 Javed F, ALHarthi SS, BinShabaib MS, Gajendra S, Romanos GE, Rahman I. Toxicological impact of waterpipe smoking and flavorings in the oral cavity and respiratory system. Inhalation Toxicology. 1-8. PMID 29039225 DOI: 10.1080/08958378.2017.1384084  1
2017 Sundar IK, Rashid K, Sellix MT, Rahman I. The nuclear receptor and clock gene REV-ERBα regulates cigarette smoke-induced lung inflammation. Biochemical and Biophysical Research Communications. PMID 28974420 DOI: 10.1016/j.bbrc.2017.09.157  1
2017 Rahman I, De Cunto G, Sundar IK, Lungarella G. Vulnerability and Genetic Susceptibility to Cigarette Smoke-Induced Emphysema in Mice. American Journal of Respiratory Cell and Molecular Biology. 57: 270-271. PMID 28862508 DOI: 10.1165/rcmb.2017-0175ED  1
2017 Behrsing H, Hill E, Raabe H, Tice R, Fitzpatrick S, Devlin R, Pinkerton K, Oberdörster G, Wright C, Wieczorek R, Aufderheide M, Steiner S, Krebs T, Asgharian B, Corley R, ... ... Rahman I, et al. In vitro exposure systems and dosimetry assessment tools for inhaled tobacco products: Workshop proceedings, conclusions and paths forward for in vitro model use. Alternatives to Laboratory Animals : Atla. 45: 117-158. PMID 28816053  1
2017 Javed F, Abduljabbar T, Vohra F, Malmstrom H, Rahman I, Romanos GE. Comparison of Periodontal Parameters and Self-Perceived Oral Symptoms among Cigarette-Smokers, Individuals Vaping Electronic-Cigarettes and Never-Smokers: A Pilot Study. Journal of Periodontology. 1-9. PMID 28644108 DOI: 10.1902/jop.2017.170197  1
2017 Sundar IK, Yin Q, Baier BS, Yan L, Mazur W, Li D, Susiarjo M, Rahman I. DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD. Clinical Epigenetics. 9: 38. PMID 28416970 DOI: 10.1186/s13148-017-0335-5  1
2017 Gerloff J, Sundar IK, Freter R, Sekera ER, Friedman AE, Robinson R, Pagano T, Rahman I. Inflammatory Response and Barrier Dysfunction by Different e-Cigarette Flavoring Chemicals Identified by Gas Chromatography-Mass Spectrometry in e-Liquids and e-Vapors on Human Lung Epithelial Cells and Fibroblasts. Applied in Vitro Toxicology. 3: 28-40. PMID 28337465 DOI: 10.1089/aivt.2016.0030  1
2017 Lei W, Lerner C, Sundar IK, Rahman I. Myofibroblast differentiation and its functional properties are inhibited by nicotine and e-cigarette via mitochondrial OXPHOS complex III. Scientific Reports. 7: 43213. PMID 28256533 DOI: 10.1038/srep43213  1
2017 Javed F, Kellesarian SV, Sundar IK, Romanos GE, Rahman I. Recent Updates on Electronic Cigarette Aerosol and Inhaled Nicotine Effects on Periodontal and Pulmonary Tissues. Oral Diseases. PMID 28168771 DOI: 10.1111/odi.12652  1
2017 Lee H, Park JR, Kim WJ, Sundar IK, Rahman I, Park SM, Yang SR. Blockade of RAGE ameliorates elastase-induced emphysema development and progression via RAGE-DAMP signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28148566 DOI: 10.1096/fj.201601155R  1
2016 Lerner CA, Lei W, Sundar IK, Rahman I. Genetic Ablation of CXCR2 Protects against Cigarette Smoke-Induced Lung Inflammation and Injury. Frontiers in Pharmacology. 7: 391. PMID 27826243 DOI: 10.3389/fphar.2016.00391  1
2016 Sundar IK, Rahman I. Gene expression profiling of epigenetic chromatin modification enzymes and histone marks by cigarette smoke: Implications for COPD and lung cancer. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00253.2016. PMID 27793800 DOI: 10.1152/ajplung.00253.2016  1
2016 Sundar IK, Javed F, Romanos GE, Rahman I. E-cigarettes and flavorings induce inflammatory and pro-senescence responses in oral epithelial cells and periodontal fibroblasts. Oncotarget. PMID 27791204 DOI: 10.18632/oncotarget.12857  1
2016 Ahmad T, Sundar IK, Tormos AM, Lerner CA, Gerloff J, Yao H, Rahman I. Shelterin TPP1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirt1 Deacetylase in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory Cell and Molecular Biology. PMID 27559927 DOI: 10.1165/rcmb.2016-0198OC  1
2016 Lerner CA, Sundar IK, Rahman I. Mitochondrial redox system, dynamics, and dysfunction in lung inflammaging and COPD. The International Journal of Biochemistry & Cell Biology. PMID 27474491 DOI: 10.1016/j.biocel.2016.07.026  1
2016 Lerner CA, Rutagarama P, Ahmad T, Sundar IK, Elder A, Rahman I. Electronic cigarette aerosols and copper nanoparticles induce mitochondrial stress and promote DNA fragmentation in lung fibroblasts. Biochemical and Biophysical Research Communications. PMID 27343559 DOI: 10.1016/j.bbrc.2016.06.109  1
2015 Javed F, Al-Kheraif AA, Rahman I, Millan-Luongo LT, Feng C, Yunker M, Malmstrom H, Romanos GE. Comparison of Clinical and Radiographic Periodontal Status Among Habitual Waterpipe Smokers and Cigarette Smokers. Journal of Periodontology. 1-9. PMID 26430928 DOI: 10.1902/jop.2015.150235  1
2015 Sundar IK, Yao H, Sellix MT, Rahman I. Circadian Molecular Clock in Lung Pathophysiology. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00152.2015. PMID 26361874 DOI: 10.1152/ajplung.00152.2015  1
2015 Pagano T, DiFrancesco AG, Smith SB, George J, Wink G, Rahman I, Robinson RJ. Determination of Nicotine Content and Delivery in Disposable Electronic Cigarettes Available in the United States by Gas Chromatography-Mass Spectrometry. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 26045251 DOI: 10.1093/ntr/ntv120  1
2015 Sundar IK, Yao H, Sellix MT, Rahman I. Circadian Clock Coupled Lung Cellular and Molecular Functions in Chronic Airway Diseases. American Journal of Respiratory Cell and Molecular Biology. PMID 25938935 DOI: 10.1165/rcmb.2014-0476TR  1
2015 Sundar IK, Ahmad T, Yao H, Hwang JW, Gerloff J, Lawrence BP, Sellix MT, Rahman I. Influenza A virus-dependent remodeling of pulmonary clock function in a mouse model of COPD. Scientific Reports. 4: 9927. PMID 25923474 DOI: 10.1038/srep09927  1
2015 Yao H, Sundar IK, Huang Y, Gerloff J, Sellix MT, Sime PJ, Rahman I. Disruption of SIRT1-mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease. American Journal of Respiratory Cell and Molecular Biology. PMID 25905433 DOI: 10.1165/rcmb.2014-0474OC  1
2015 Ahmad T, Sundar IK, Lerner CA, Gerloff J, Tormos AM, Yao H, Rahman I. Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 2912-29. PMID 25792665 DOI: 10.1096/fj.14-268276  1
2015 Lerner CA, Sundar IK, Yao H, Gerloff J, Ossip DJ, McIntosh S, Robinson R, Rahman I. Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung. Plos One. 10: e0116732. PMID 25658421 DOI: 10.1371/journal.pone.0116732  1
2015 Lerner CA, Sundar IK, Watson RM, Elder A, Jones R, Done D, Kurtzman R, Ossip DJ, Robinson R, McIntosh S, Rahman I. Environmental health hazards of e-cigarettes and their components: Oxidants and copper in e-cigarette aerosols. Environmental Pollution (Barking, Essex : 1987). 198: 100-7. PMID 25577651 DOI: 10.1016/j.envpol.2014.12.033  1
2014 Yao H, Sundar IK, Ahmad T, Lerner C, Gerloff J, Friedman AE, Phipps RP, Sime PJ, McBurney MW, Guarente L, Rahman I. SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism. American Journal of Physiology. Lung Cellular and Molecular Physiology. 306: L816-28. PMID 24633890 DOI: 10.1152/ajplung.00323.2013  1
2014 Sundar IK, Yao H, Huang Y, Lyda E, Sime PJ, Sellix MT, Rahman I. Serotonin and corticosterone rhythms in mice exposed to cigarette smoke and in patients with COPD: implication for COPD-associated neuropathogenesis. Plos One. 9: e87999. PMID 24520342 DOI: 10.1371/journal.pone.0087999  1
2014 Sundar IK, Nevid MZ, Friedman AE, Rahman I. Cigarette smoke induces distinct histone modifications in lung cells: implications for the pathogenesis of COPD and lung cancer. Journal of Proteome Research. 13: 982-96. PMID 24283195 DOI: 10.1021/pr400998n  1
2014 Hwang JW, Sundar IK, Yao H, Sellix MT, Rahman I. Circadian clock function is disrupted by environmental tobacco/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 176-94. PMID 24025728 DOI: 10.1096/fj.13-232629  1
2013 Gilels F, Paquette ST, Zhang J, Rahman I, White PM. Mutation of Foxo3 causes adult onset auditory neuropathy and alters cochlear synapse architecture in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 18409-24. PMID 24259566 DOI: 10.1523/JNEUROSCI.2529-13.2013  1
2013 Yao H, Sundar IK, Gorbunova V, Rahman I. P21-PARP-1 pathway is involved in cigarette smoke-induced lung DNA damage and cellular senescence. Plos One. 8: e80007. PMID 24244594 DOI: 10.1371/journal.pone.0080007  1
2013 Lam HC, Cloonan SM, Bhashyam AR, Haspel JA, Singh A, Sathirapongsasuti JF, Cervo M, Yao H, Chung AL, Mizumura K, An CH, Shan B, Franks JM, Haley KJ, Owen CA, ... ... Rahman I, et al. Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction. The Journal of Clinical Investigation. 123: 5212-30. PMID 24200693 DOI: 10.1172/JCI69636  1
2013 Yao H, Hwang JW, Sundar IK, Friedman AE, McBurney MW, Guarente L, Gu W, Kinnula VL, Rahman I. SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. American Journal of Physiology. Lung Cellular and Molecular Physiology. 305: L615-24. PMID 24039251 DOI: 10.1152/ajplung.00249.2012  1
2013 Hwang JW, Yao H, Caito S, Sundar IK, Rahman I. Redox regulation of SIRT1 in inflammation and cellular senescence. Free Radical Biology & Medicine. 61: 95-110. PMID 23542362 DOI: 10.1016/j.freeradbiomed.2013.03.015  1
2013 Rahman I. Retraction: cigarette smoke-induced oxidative/nitrosative stress impairs VEGF- and fluid shear stress-mediated signaling in endothelial cells. Edirisinghe I, Arunachalam G, Wong C, Yao H, Rahman A, Phipps RP, Jin ZG, and Rahman I. Antioxid Redox Signal 12: 1355-1369, 2010. Antioxidants & Redox Signaling. 18: 1535. PMID 23259579 DOI: 10.1089/ars.2012.5170  0.01
2013 Sundar IK, Yao H, Rahman I. Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases. Antioxidants & Redox Signaling. 18: 1956-71. PMID 22978694 DOI: 10.1089/ars.2012.4863  1
2013 Hwang JW, Sundar IK, Yao H, Rahman I. SIRT1 and Inflammaging in Chronic Obstructive Pulmonary Disease Inflammation, Advancing Age and Nutrition: Research and Clinical Interventions. 183-191. DOI: 10.1016/B978-0-12-397803-5.00015-0  1
2012 Agarwal AR, Zhao L, Sancheti H, Sundar IK, Rahman I, Cadenas E. Short-term cigarette smoke exposure induces reversible changes in energy metabolism and cellular redox status independent of inflammatory responses in mouse lungs. American Journal of Physiology. Lung Cellular and Molecular Physiology. 303: L889-98. PMID 23064950 DOI: 10.1152/ajplung.00219.2012  1
2012 Yao H, Rahman I. Role of histone deacetylase 2 in epigenetics and cellular senescence: implications in lung inflammaging and COPD. American Journal of Physiology. Lung Cellular and Molecular Physiology. 303: L557-66. PMID 22842217 DOI: 10.1152/ajplung.00175.2012  1
2012 Basic VT, Tadele E, Elmabsout AA, Yao H, Rahman I, Sirsjö A, Abdel-Halim SM. Exposure to cigarette smoke induces overexpression of von Hippel-Lindau tumor suppressor in mouse skeletal muscle. American Journal of Physiology. Lung Cellular and Molecular Physiology. 303: L519-27. PMID 22842216 DOI: 10.1152/ajplung.00007.2012  1
2012 Yao H, Rahman I. Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence. Biochemical Pharmacology. 84: 1332-9. PMID 22796566 DOI: 10.1016/j.bcp.2012.06.031  1
2012 Rahman I, Kinnula VL. Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease. Expert Review of Clinical Pharmacology. 5: 293-309. PMID 22697592 DOI: 10.1586/ecp.12.16  1
2012 Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Rönty M, Kinnula VL, Rahman I. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. The Journal of Clinical Investigation. 122: 2032-45. PMID 22546858 DOI: 10.1172/JCI60132  1
2012 Rahman I, MacNee W. Antioxidant pharmacological therapies for COPD. Current Opinion in Pharmacology. 12: 256-65. PMID 22349417 DOI: 10.1016/j.coph.2012.01.015  1
2012 Sundar IK, Chung S, Hwang JW, Lapek JD, Bulger M, Friedman AE, Yao H, Davie JR, Rahman I. Mitogen- and stress-activated kinase 1 (MSK1) regulates cigarette smoke-induced histone modifications on NF-κB-dependent genes. Plos One. 7: e31378. PMID 22312446 DOI: 10.1371/journal.pone.0031378  1
2012 Yang SR, Rahman I, Trosko JE, Kang KS. Oxidative stress-induced biomarkers for stem cell-based chemical screening. Preventive Medicine. 54: S42-9. PMID 22197760 DOI: 10.1016/j.ypmed.2011.11.013  1
2012 Rahman I, Kinnula VL, Gorbunova V, Yao H. SIRT1 as a therapeutic target in inflammaging of the pulmonary disease. Preventive Medicine. 54: S20-8. PMID 22178470 DOI: 10.1016/j.ypmed.2011.11.014  1
2012 Rahman I. Pharmacological antioxidant strategies as therapeutic interventions for COPD. Biochimica Et Biophysica Acta. 1822: 714-28. PMID 22101076 DOI: 10.1016/j.bbadis.2011.11.004  0.01
2011 Mortaz E, Masjedi MR, Rahman I. Outcome of Smoking Cessation on Airway Remodeling and Pulmonary Inflammation in COPD Patients. Tanaffos. 10: 7-11. PMID 25191369  1
2011 Sundar IK, Rahman I. Vitamin d and susceptibility of chronic lung diseases: role of epigenetics. Frontiers in Pharmacology. 2: 50. PMID 21941510 DOI: 10.3389/fphar.2011.00050  1
2011 Chung S, Sundar IK, Hwang JW, Yull FE, Blackwell TS, Kinnula VL, Bulger M, Yao H, Rahman I. NF-κB inducing kinase, NIK mediates cigarette smoke/TNFα-induced histone acetylation and inflammation through differential activation of IKKs. Plos One. 6: e23488. PMID 21887257 DOI: 10.1371/journal.pone.0023488  1
2011 Nadtochiy SM, Yao H, McBurney MW, Gu W, Guarente L, Rahman I, Brookes PS. SIRT1-mediated acute cardioprotection. American Journal of Physiology. Heart and Circulatory Physiology. 301: H1506-12. PMID 21856913 DOI: 10.1152/ajpheart.00587.2011  1
2011 Hwang JW, Rajendrasozhan S, Yao H, Chung S, Sundar IK, Huyck HL, Pryhuber GS, Kinnula VL, Rahman I. FOXO3 deficiency leads to increased susceptibility to cigarette smoke-induced inflammation, airspace enlargement, and chronic obstructive pulmonary disease. Journal of Immunology (Baltimore, Md. : 1950). 187: 987-98. PMID 21690325 DOI: 10.4049/jimmunol.1001861  1
2011 Regan EA, Mazur W, Meoni E, Toljamo T, Millar J, Vuopala K, Bowler RP, Rahman I, Nicks ME, Crapo JD, Kinnula VL. Smoking and COPD increase sputum levels of extracellular superoxide dismutase Free Radical Biology and Medicine. 51: 726-732. PMID 21621610 DOI: 10.1016/j.freeradbiomed.2011.05.008  1
2011 Sundar IK, Mullapudi N, Yao H, Spivack SD, Rahman I. Lung cancer and its association with chronic obstructive pulmonary disease: update on nexus of epigenetics. Current Opinion in Pulmonary Medicine. 17: 279-85. PMID 21537190 DOI: 10.1097/MCP.0b013e3283477533  1
2011 Sundar IK, Hwang JW, Wu S, Sun J, Rahman I. Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation. Biochemical and Biophysical Research Communications. 406: 127-33. PMID 21300024 DOI: 10.1016/j.bbrc.2011.02.011  1
2011 Yao H, Rahman I. Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease. Toxicology and Applied Pharmacology. 254: 72-85. PMID 21296096 DOI: 10.1016/j.taap.2009.10.022  1
2011 Londhe VA, Sundar IK, Lopez B, Maisonet TM, Yu Y, Aghai ZH, Rahman I. Hyperoxia impairs alveolar formation and induces senescence through decreased histone deacetylase activity and up-regulation of p21 in neonatal mouse lung. Pediatric Research. 69: 371-7. PMID 21270677 DOI: 10.1203/PDR.0b013e318211c917  1
2011 Nadtochiy SM, Redman E, Rahman I, Brookes PS. Lysine deacetylation in ischaemic preconditioning: the role of SIRT1. Cardiovascular Research. 89: 643-9. PMID 20823277 DOI: 10.1093/cvr/cvq287  1
2010 Rahman I, Chung S. Dietary polyphenols, deacetylases and chromatin remodeling in inflammation. Journal of Nutrigenetics and Nutrigenomics. 3: 220-30. PMID 21474953 DOI: 10.1159/000324358  1
2010 Adenuga D, Caito S, Yao H, Sundar IK, Hwang JW, Chung S, Rahman I. Nrf2 deficiency influences susceptibility to steroid resistance via HDAC2 reduction. Biochemical and Biophysical Research Communications. 403: 452-6. PMID 21094147 DOI: 10.1016/j.bbrc.2010.11.054  1
2010 Sundar IK, Chung S, Hwang JW, Arunachalam G, Cook S, Yao H, Mazur W, Kinnula VL, Fisher AB, Rahman I. Peroxiredoxin 6 differentially regulates acute and chronic cigarette smoke–mediated lung inflammatory response and injury. Experimental Lung Research. 36: 451-62. PMID 20939758 DOI: 10.3109/01902141003754128  1
2010 Ishikawa N, Ohlmeier S, Salmenkivi K, Myllärniemi M, Rahman I, Mazur W, Kinnula VL. Hemoglobin α and β are ubiquitous in the human lung, decline in idiopathic pulmonary fibrosis but not in COPD. Respiratory Research. 11: 123. PMID 20836851 DOI: 10.1186/1465-9921-11-123  1
2010 Edirisinghe I, Rahman I. Cigarette smoke-mediated oxidative stress, shear stress, and endothelial dysfunction: role of VEGFR2. Annals of the New York Academy of Sciences. 1203: 66-72. PMID 20716285 DOI: 10.1111/j.1749-6632.2010.05601.x  1
2010 Yao H, Arunachalam G, Hwang JW, Chung S, Sundar IK, Kinnula VL, Crapo JD, Rahman I. Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM Proceedings of the National Academy of Sciences of the United States of America. 107: 15571-15576. PMID 20713693 DOI: 10.1073/pnas.1007625107  1
2010 Arunachalam G, Sundar IK, Hwang JW, Yao H, Rahman I. Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD. Journal of Inflammation (London, England). 7: 34. PMID 20663150 DOI: 10.1186/1476-9255-7-34  1
2010 Sundar IK, Caito S, Yao H, Rahman I. Oxidative stress, thiol redox signaling methods in epigenetics. Methods in Enzymology. 474: 213-44. PMID 20609913 DOI: 10.1016/S0076-6879(10)74013-1  1
2010 Hwang JW, Chung S, Sundar IK, Yao H, Arunachalam G, McBurney MW, Rahman I. Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD. Archives of Biochemistry and Biophysics. 500: 203-9. PMID 20493163 DOI: 10.1016/j.abb.2010.05.013  1
2010 Chung S, Sundar IK, Yao H, Ho YS, Rahman I. Glutaredoxin 1 regulates cigarette smoke-mediated lung inflammation through differential modulation of I{kappa}B kinases in mice: impact on histone acetylation. American Journal of Physiology. Lung Cellular and Molecular Physiology. 299: L192-203. PMID 20472709 DOI: 10.1152/ajplung.00426.2009  1
2010 Chung S, Yao H, Caito S, Hwang JW, Arunachalam G, Rahman I. Regulation of SIRT1 in cellular functions: role of polyphenols. Archives of Biochemistry and Biophysics. 501: 79-90. PMID 20450879 DOI: 10.1016/j.abb.2010.05.003  1
2010 Rahman I, Chung S. Dietary polyphenols, deacetylases and chromatin remodeling in inflammation. World Review of Nutrition and Dietetics. 101: 84-94. PMID 20436255 DOI: 10.1159/000314513  1
2010 Adenuga D, Rahman I. Protein kinase CK2-mediated phosphorylation of HDAC2 regulates co-repressor formation, deacetylase activity and acetylation of HDAC2 by cigarette smoke and aldehydes. Archives of Biochemistry and Biophysics. 498: 62-73. PMID 20388487 DOI: 10.1016/j.abb.2010.04.002  1
2010 Caito S, Rajendrasozhan S, Cook S, Chung S, Yao H, Friedman AE, Brookes PS, Rahman I. SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 3145-59. PMID 20385619 DOI: 10.1096/fj.09-151308  1
2010 Marwick JA, Edirisinghe I, Arunachalam G, Stevenson CS, Macnee W, Kirkham PA, Rahman I. Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs. Journal of Inflammation (London, England). 7: 11. PMID 20205917 DOI: 10.1186/1476-9255-7-11  1
2010 Arunachalam G, Yao H, Sundar IK, Caito S, Rahman I. SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol. Biochemical and Biophysical Research Communications. 393: 66-72. PMID 20102704 DOI: 10.1016/j.bbrc.2010.01.080  1
2010 Rajendrasozhan S, Hwang JW, Yao H, Kishore N, Rahman I. Anti-inflammatory effect of a selective IkappaB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke. Pulmonary Pharmacology & Therapeutics. 23: 172-81. PMID 20080200 DOI: 10.1016/j.pupt.2010.01.002  1
2010 Vibhuti A, Arif E, Mishra A, Deepak D, Singh B, Rahman I, Mohammad G, Pasha MA. CYP1A1, CYP1A2 and CYBA gene polymorphisms associated with oxidative stress in COPD. Clinica Chimica Acta; International Journal of Clinical Chemistry. 411: 474-80. PMID 20080081 DOI: 10.1016/j.cca.2009.12.018  0.01
2010 Caito S, Hwang JW, Chung S, Yao H, Sundar IK, Rahman I. PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity. Biochemical and Biophysical Research Communications. 392: 264-70. PMID 20060806 DOI: 10.1016/j.bbrc.2009.12.161  1
2010 Yao H, Hwang JW, Moscat J, Diaz-Meco MT, Leitges M, Kishore N, Li X, Rahman I. Protein kinase C zeta mediates cigarette smoke/aldehyde- and lipopolysaccharide-induced lung inflammation and histone modifications. The Journal of Biological Chemistry. 285: 5405-16. PMID 20007975 DOI: 10.1074/jbc.M109.041418  1
2010 Rajendrasozhan S, Chung S, Sundar IK, Yao H, Rahman I. Targeted disruption of NF-{kappa}B1 (p50) augments cigarette smoke-induced lung inflammation and emphysema in mice: a critical role of p50 in chromatin remodeling. American Journal of Physiology. Lung Cellular and Molecular Physiology. 298: L197-209. PMID 19965984 DOI: 10.1152/ajplung.00265.2009  1
2010 Edirisinghe I, Arunachalam G, Wong C, Yao H, Rahman A, Phipps RP, Jin ZG, Rahman I. Cigarette-smoke-induced oxidative/nitrosative stress impairs VEGF- and fluid-shear-stress-mediated signaling in endothelial cells. Antioxidants & Redox Signaling. 12: 1355-69. PMID 19929443 DOI: 10.1089/ars.2009.2874  1
2009 Rajendrasozhan S, Yao H, Rahman I. Current perspectives on role of chromatin modifications and deacetylases in lung inflammation in COPD. Copd. 6: 291-7. PMID 19811389 DOI: 10.1080/15412550903049132  1
2009 Zakkar M, Van der Heiden K, Luong le A, Chaudhury H, Cuhlmann S, Hamdulay SS, Krams R, Edirisinghe I, Rahman I, Carlsen H, Haskard DO, Mason JC, Evans PC. Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 1851-7. PMID 19729611 DOI: 10.1161/ATVBAHA.109.193375  1
2009 Yao H, Rahman I. Current concepts on the role of inflammation in COPD and lung cancer. Current Opinion in Pharmacology. 9: 375-83. PMID 19615942 DOI: 10.1016/j.coph.2009.06.009  1
2009 Sarir H, Mortaz E, Karimi K, Kraneveld AD, Rahman I, Caldenhoven E, Nijkamp FP, Folkerts G. Cigarette smoke regulates the expression of TLR4 and IL-8 production by human macrophages. Journal of Inflammation (London, England). 6: 12. PMID 19409098 DOI: 10.1186/1476-9255-6-12  0.01
2009 Adenuga D, Yao H, March TH, Seagrave J, Rahman I. Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke. American Journal of Respiratory Cell and Molecular Biology. 40: 464-73. PMID 18927347 DOI: 10.1165/rcmb.2008-0255OC  1
2009 Biswas SK, Rahman I. Environmental toxicity, redox signaling and lung inflammation: the role of glutathione. Molecular Aspects of Medicine. 30: 60-76. PMID 18760298 DOI: 10.1016/j.mam.2008.07.001  1
2009 Yang SR, Yao H, Rajendrasozhan S, Chung S, Edirisinghe I, Valvo S, Fromm G, McCabe MJ, Sime PJ, Phipps RP, Li JD, Bulger M, Rahman I. RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke. American Journal of Respiratory Cell and Molecular Biology. 40: 147-58. PMID 18688039 DOI: 10.1165/rcmb.2008-0207OC  1
2008 Yao H, de Boer WI, Rahman I. Targeting lung inflammation: novel therapies for the treatment of COPD. Current Respiratory Medicine Reviews. 4: 57-68. PMID 19672474 DOI: 10.2174/157339808783497873  1
2008 Louhelainen N, Myllärniemi M, Rahman I, Kinnula VL. Airway biomarkers of the oxidant burden in asthma and chronic obstructive pulmonary disease: current and future perspectives. International Journal of Chronic Obstructive Pulmonary Disease. 3: 585-603. PMID 19281076  1
2008 Rahman I. Antioxidant therapeutic advances in COPD. Therapeutic Advances in Respiratory Disease. 2: 351-74. PMID 19124382 DOI: 10.1177/1753465808098224  0.01
2008 Debret R, Brassart-Pasco S, Lorin J, Martoriati A, Deshorgue A, Maquart FX, Hornebeck W, Rahman I, Antonicelli F. Ceramide inhibition of MMP-2 expression and human cancer bronchial cell invasiveness involve decreased histone acetylation. Biochimica Et Biophysica Acta. 1783: 1718-27. PMID 18598724 DOI: 10.1016/j.bbamcr.2008.06.001  1
2008 Meja KK, Rajendrasozhan S, Adenuga D, Biswas SK, Sundar IK, Spooner G, Marwick JA, Chakravarty P, Fletcher D, Whittaker P, Megson IL, Kirkham PA, Rahman I. Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. American Journal of Respiratory Cell and Molecular Biology. 39: 312-23. PMID 18421014 DOI: 10.1165/rcmb.2008-0012OC  1
2008 Yao H, Edirisinghe I, Yang SR, Rajendrasozhan S, Kode A, Caito S, Adenuga D, Rahman I. Genetic ablation of NADPH oxidase enhances susceptibility to cigarette smoke-induced lung inflammation and emphysema in mice. The American Journal of Pathology. 172: 1222-37. PMID 18403597 DOI: 10.2353/ajpath.2008.070765  1
2008 Yao H, Edirisinghe I, Rajendrasozhan S, Yang SR, Caito S, Adenuga D, Rahman I. Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice. American Journal of Physiology. Lung Cellular and Molecular Physiology. 294: L1174-86. PMID 18375740 DOI: 10.1152/ajplung.00439.2007  1
2008 Edirisinghe I, Yang SR, Yao H, Rajendrasozhan S, Caito S, Adenuga D, Wong C, Rahman A, Phipps RP, Jin ZG, Rahman I. VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 2297-310. PMID 18263699 DOI: 10.1096/fj.07-099481  1
2008 Yao H, Yang SR, Edirisinghe I, Rajendrasozhan S, Caito S, Adenuga D, O'Reilly MA, Rahman I. Disruption of p21 attenuates lung inflammation induced by cigarette smoke, LPS, and fMLP in mice. American Journal of Respiratory Cell and Molecular Biology. 39: 7-18. PMID 18239191 DOI: 10.1165/rcmb.2007-0342OC  1
2008 Yang SR, Valvo S, Yao H, Kode A, Rajendrasozhan S, Edirisinghe I, Caito S, Adenuga D, Henry R, Fromm G, Maggirwar S, Li JD, Bulger M, Rahman I. IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung. American Journal of Respiratory Cell and Molecular Biology. 38: 689-98. PMID 18239189 DOI: 10.1165/rcmb.2007-0379OC  1
2008 Rajendrasozhan S, Yang SR, Edirisinghe I, Yao H, Adenuga D, Rahman I. Deacetylases and NF-kappaB in redox regulation of cigarette smoke-induced lung inflammation: epigenetics in pathogenesis of COPD. Antioxidants & Redox Signaling. 10: 799-811. PMID 18220485 DOI: 10.1089/ars.2007.1938  1
2008 Rajendrasozhan S, Yang SR, Kinnula VL, Rahman I. SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine. 177: 861-70. PMID 18174544 DOI: 10.1164/rccm.200708-1269OC  1
2008 Kode A, Rajendrasozhan S, Caito S, Yang SR, Megson IL, Rahman I. Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 294: L478-88. PMID 18162601 DOI: 10.1152/ajplung.00361.2007  1
2008 Caito S, Yang SR, Kode A, Edirisinghe I, Rajendrasozhan S, Phipps RP, Rahman I. Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, PPARgamma agonists, differentially regulate cigarette smoke-mediated pro-inflammatory cytokine release in monocytes/macrophages. Antioxidants & Redox Signaling. 10: 253-60. PMID 17970647 DOI: 10.1089/ars.2007.1889  1
2008 Ryan EP, Bushnell TP, Friedman AE, Rahman I, Phipps RP. Cyclooxygenase-2 independent effects of cyclooxygenase-2 inhibitors on oxidative stress and intracellular glutathione content in normal and malignant human B-cells. Cancer Immunology, Immunotherapy : Cii. 57: 347-58. PMID 17668203 DOI: 10.1007/s00262-007-0374-4  1
2007 de Boer WI, Yao H, Rahman I. Future therapeutic treatment of COPD: struggle between oxidants and cytokines. International Journal of Chronic Obstructive Pulmonary Disease. 2: 205-28. PMID 18229560  1
2007 Stevenson CS, Docx C, Webster R, Battram C, Hynx D, Giddings J, Cooper PR, Chakravarty P, Rahman I, Marwick JA, Kirkham PA, Charman C, Richardson DL, Nirmala NR, Whittaker P, et al. Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation. American Journal of Physiology. Lung Cellular and Molecular Physiology. 293: L1183-93. PMID 17720875 DOI: 10.1152/ajplung.00105.2007  1
2007 Aghai ZH, Kode A, Saslow JG, Nakhla T, Farhath S, Stahl GE, Eydelman R, Strande L, Leone P, Rahman I. Azithromycin suppresses activation of nuclear factor-kappa B and synthesis of pro-inflammatory cytokines in tracheal aspirate cells from premature infants. Pediatric Research. 62: 483-8. PMID 17667842 DOI: 10.1203/PDR.0b013e318142582d  1
2007 Yang SR, Wright J, Bauter M, Seweryniak K, Kode A, Rahman I. Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging. American Journal of Physiology. Lung Cellular and Molecular Physiology. 292: L567-76. PMID 17041012 DOI: 10.1152/ajplung.00308.2006  1
2006 Rahman I. Antioxidant therapies in COPD. International Journal of Chronic Obstructive Pulmonary Disease. 1: 15-29. PMID 18046899  0.01
2006 Rahman I, Kode A, Biswas SK. Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nature Protocols. 1: 3159-65. PMID 17406579 DOI: 10.1038/nprot.2006.378  1
2006 Kode A, Yang SR, Rahman I. Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells. Respiratory Research. 7: 132. PMID 17062156 DOI: 10.1186/1465-9921-7-132  1
2006 Morrison D, Rahman I, MacNee W. Permeability, inflammation and oxidant status in airspace epithelium exposed to ozone. Respiratory Medicine. 100: 2227-34. PMID 17023150 DOI: 10.1016/j.rmed.2005.10.005  1
2006 Rahman I, Yang SR, Biswas SK. Current concepts of redox signaling in the lungs. Antioxidants & Redox Signaling. 8: 681-9. PMID 16677111 DOI: 10.1089/ars.2006.8.681  1
2006 Aghai ZH, Kumar S, Farhath S, Kumar MA, Saslow J, Nakhla T, Eydelman R, Strande L, Stahl G, Hewitt C, Nesin M, Rahman I. Dexamethasone suppresses expression of Nuclear Factor-kappaB in the cells of tracheobronchial lavage fluid in premature neonates with respiratory distress. Pediatric Research. 59: 811-5. PMID 16641216 DOI: 10.1203/01.pdr.0000219120.92049.b3  1
2006 Yang SR, Chida AS, Bauter MR, Shafiq N, Seweryniak K, Maggirwar SB, Kilty I, Rahman I. Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages. American Journal of Physiology. Lung Cellular and Molecular Physiology. 291: L46-57. PMID 16473865 DOI: 10.1152/ajplung.00241.2005  1
2006 Baglole CJ, Bushinsky SM, Garcia TM, Kode A, Rahman I, Sime PJ, Phipps RP. Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema. American Journal of Physiology. Lung Cellular and Molecular Physiology. 291: L19-29. PMID 16443644 DOI: 10.1152/ajplung.00306.2005  1
2006 Marwick JA, Stevenson CS, Giddings J, MacNee W, Butler K, Rahman I, Kirkham PA. Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition. American Journal of Physiology. Lung Cellular and Molecular Physiology. 290: L897-908. PMID 16361360 DOI: 10.1152/ajplung.00116.2005  1
2005 Echazarreta AL, Rahman I, Peinado V, Barberà JA, Roca J, MacNee W, Rodríguez-Roisin R. Lack of systemic oxidative stress during PAF challenge in mild asthma. Respiratory Medicine. 99: 519-23. PMID 15823446 DOI: 10.1016/j.rmed.2004.10.013  1
2005 Rahman I, Biswas SK, Jimenez LA, Torres M, Forman HJ. Glutathione, stress responses, and redox signaling in lung inflammation. Antioxidants & Redox Signaling. 7: 42-59. PMID 15650395 DOI: 10.1089/ars.2005.7.42  1
2005 Biswas SK, McClure D, Jimenez LA, Megson IL, Rahman I. Curcumin induces glutathione biosynthesis and inhibits NF-kappaB activation and interleukin-8 release in alveolar epithelial cells: mechanism of free radical scavenging activity. Antioxidants & Redox Signaling. 7: 32-41. PMID 15650394 DOI: 10.1089/ars.2005.7.32  1
2004 Marwick JA, Kirkham PA, Stevenson CS, Danahay H, Giddings J, Butler K, Donaldson K, Macnee W, Rahman I. Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs. American Journal of Respiratory Cell and Molecular Biology. 31: 633-42. PMID 15333327 DOI: 10.1165/rcmb.2004-0006OC  1
2004 Rahman I, Biswas SK. Non-invasive biomarkers of oxidative stress: Reproducibility and methodological issues Redox Report. 9: 125-143. PMID 15327743 DOI: 10.1179/135100004225005219  1
2004 Antonicelli F, Brown D, Parmentier M, Drost EM, Hirani N, Rahman I, Donaldson K, MacNee W. Regulation of LPS-mediated inflammation in vivo and in vitro by the thiol antioxidant Nacystelyn. American Journal of Physiology. Lung Cellular and Molecular Physiology. 286: L1319-27. PMID 15136298 DOI: 10.1152/ajplung.00329.2003  1
2003 Donaldson K, Stone V, Borm PJ, Jimenez LA, Gilmour PS, Schins RP, Knaapen AM, Rahman I, Faux SP, Brown DM, MacNee W. Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10). Free Radical Biology & Medicine. 34: 1369-82. PMID 12757847  1
2003 Wickenden JA, Clarke MC, Rossi AG, Rahman I, Faux SP, Donaldson K, MacNee W. Cigarette smoke prevents apoptosis through inhibition of caspase activation and induces necrosis. American Journal of Respiratory Cell and Molecular Biology. 29: 562-70. PMID 12748058 DOI: 10.1165/rcmb.2002-0235OC  1
2003 Rahman I, Gilmour PS, Jimenez LA, Biswas SK, Antonicelli F, Aruoma OI. Ergothioneine inhibits oxidative stress- and TNF-alpha-induced NF-kappa B activation and interleukin-8 release in alveolar epithelial cells. Biochemical and Biophysical Research Communications. 302: 860-4. PMID 12646250 DOI: 10.1016/S0006-291X(03)00224-9  1
2003 Gilmour PS, Rahman I, Donaldson K, MacNee W. Histone acetylation regulates epithelial IL-8 release mediated by oxidative stress from environmental particles. American Journal of Physiology. Lung Cellular and Molecular Physiology. 284: L533-40. PMID 12573991 DOI: 10.1152/ajplung.00277.2002  1
2002 Marwick JA, Kirkham P, Gilmour PS, Donaldson K, MacNEE W, Rahman I. Cigarette smoke-induced oxidative stress and TGF-beta1 increase p21waf1/cip1 expression in alveolar epithelial cells. Annals of the New York Academy of Sciences. 973: 278-83. PMID 12485877  1
2002 Rahman I, van Schadewijk AA, Crowther AJ, Hiemstra PS, Stolk J, MacNee W, De Boer WI. 4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine. 166: 490-5. PMID 12186826 DOI: 10.1164/rccm.2110101  1
2002 Rahman I, Gilmour PS, Jimenez LA, MacNee W. Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation. Molecular and Cellular Biochemistry. 234: 239-48. PMID 12162440  1
2002 Kim HJ, Liu X, Wang H, Kohyama T, Kobayashi T, Wen FQ, Romberger DJ, Abe S, MacNee W, Rahman I, Rennard SI. Glutathione prevents inhibition of fibroblast-mediated collagen gel contraction by cigarette smoke. American Journal of Physiology. Lung Cellular and Molecular Physiology. 283: L409-17. PMID 12114203 DOI: 10.1152/ajplung.00059.2002  1
2002 Rahman I, MacNee W. Oxidative stress and adaptive response of glutathione in bronchial epithelial cells. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. 32: 486-8. PMID 11972591  1
2002 Antonicelli F, Parmentier M, Drost EM, Hirani N, Rahman I, Donaldson K, MacNee W. Nacystelyn inhibits oxidant-mediated interleukin-8 expression and NF-kappaB nuclear binding in alveolar epithelial cells. Free Radical Biology & Medicine. 32: 492-502. PMID 11958950  1
2002 Jardine H, MacNee W, Donaldson K, Rahman I. Molecular mechanism of transforming growth factor (TGF)-beta1-induced glutathione depletion in alveolar epithelial cells. Involvement of AP-1/ARE and Fra-1. The Journal of Biological Chemistry. 277: 21158-66. PMID 11912197 DOI: 10.1074/jbc.M112145200  1
2002 Jiménez LA, Drost EM, Gilmour PS, Rahman I, Antonicelli F, Ritchie H, MacNee W, Donaldson K. PM(10)-exposed macrophages stimulate a proinflammatory response in lung epithelial cells via TNF-alpha. American Journal of Physiology. Lung Cellular and Molecular Physiology. 282: L237-48. PMID 11792628 DOI: 10.1152/ajplung.00024.2001  1
2001 Rahman I, Mulier B, Gilmour PS, Watchorn T, Donaldson K, Jeffery PK, MacNee W. Oxidant-mediated lung epithelial cell tolerance: the role of intracellular glutathione and nuclear factor-kappaB. Biochemical Pharmacology. 62: 787-94. PMID 11551525  1
2001 Gilmour PS, Rahman I, Hayashi S, Hogg JC, Donaldson K, MacNee W. Adenoviral E1A primes alveolar epithelial cells to PM(10)-induced transcription of interleukin-8. American Journal of Physiology. Lung Cellular and Molecular Physiology. 281: L598-606. PMID 11504686 DOI: 10.1152/ajplung.2001.281.3.L598  1
2001 MacNee W, Rahman I. Is oxidative stress central to the pathogenesis of chronic obstructive pulmonary disease? Trends in Molecular Medicine. 7: 55-62. PMID 11286755  1
2000 Parmentier M, Hirani N, Rahman I, Donaldson K, MacNee W, Antonicelli F. Regulation of lipopolysaccharide-mediated interleukin-1beta release by N-acetylcysteine in THP-1 cells. The European Respiratory Journal. 16: 933-9. PMID 11153595 DOI: 10.1183/09031936.00.16593300  1
2000 Rahman I, MacNee W. Oxidative stress and regulation of glutathione in lung inflammation. The European Respiratory Journal. 16: 534-54. PMID 11028671  1
2000 Rahman I, MacNee W. Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches. Free Radical Biology & Medicine. 28: 1405-20. PMID 10924859  1
2000 Miralles C, Busquets X, Santos C, Togores B, Hussain S, Rahman I, MacNee W, Agustí AG. Regulation of iNOS expression and glutathione levels in rat liver by oxygen tension. Febs Letters. 476: 253-7. PMID 10913623  1
2000 Mantle D, Patel VB, Why HJ, Ahmed S, Rahman I, MacNee W, Wassif WS, Richardson PJ, Preedy VR. Effects of lisinopril and amlodipine on antioxidant status in experimental hypertension. Clinica Chimica Acta; International Journal of Clinical Chemistry. 299: 1-10. PMID 10900288  1
2000 Jiménez LA, Thompson J, Brown DA, Rahman I, Antonicelli F, Duffin R, Drost EM, Hay RT, Donaldson K, MacNee W. Activation of NF-kappaB by PM(10) occurs via an iron-mediated mechanism in the absence of IkappaB degradation. Toxicology and Applied Pharmacology. 166: 101-10. PMID 10896851 DOI: 10.1006/taap.2000.8957  1
2000 Rahman I, van Schadewijk AA, Hiemstra PS, Stolk J, van Krieken JH, MacNee W, de Boer WI. Localization of gamma-glutamylcysteine synthetase messenger rna expression in lungs of smokers and patients with chronic obstructive pulmonary disease. Free Radical Biology & Medicine. 28: 920-5. PMID 10802223  1
2000 Rahman I, Swarska E, Henry M, Stolk J, MacNee W. Is there any relationship between plasma antioxidant capacity and lung function in smokers and in patients with chronic obstructive pulmonary disease? Thorax. 55: 189-93. PMID 10679536  1
1999 Rahman I, MacNee W. Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease. American Journal of Physiology. Lung Cellular and Molecular Physiology. 277: L1067-L1088. PMID 29592056 DOI: 10.1152/ajplung.1999.277.6.L1067  1
1999 Rahman I, MacNee W. Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease. The American Journal of Physiology. 277: L1067-88. PMID 10600876  1
1999 Macnee W, Rahman I. Oxidants and antioxidants as therapeutic targets in chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine. 160: S58-65. PMID 10556172 DOI: 10.1164/ajrccm.160.supplement_1.15  1
1999 Rahman I, Skwarska E, Henry M, Davis M, O'Connor CM, FitzGerald MX, Greening A, MacNee W. Systemic and pulmonary oxidative stress in idiopathic pulmonary fibrosis. Free Radical Biology & Medicine. 27: 60-8. PMID 10443920 DOI: 10.1016/S0891-5849(99)00035-0  1
1999 Lapperre TS, Jimenez LA, Antonicelli F, Drost EM, Hiemstra PS, Stolk J, MacNee W, Rahman I. Apocynin increases glutathione synthesis and activates AP-1 in alveolar epithelial cells. Febs Letters. 443: 235-9. PMID 9989612 DOI: 10.1016/S0014-5793(98)01723-2  1
1999 Rahman I, Antonicelli F, MacNee W. Molecular mechanism of the regulation of glutathione synthesis by tumor necrosis factor-alpha and dexamethasone in human alveolar epithelial cells. The Journal of Biological Chemistry. 274: 5088-96. PMID 9988757 DOI: 10.1074/JBC.274.8.5088  1
1999 Morrison D, Rahman I, Lannan S, MacNee W. Epithelial permeability, inflammation, and oxidant stress in the air spaces of smokers. American Journal of Respiratory and Critical Care Medicine. 159: 473-9. PMID 9927360 DOI: 10.1164/ajrccm.159.2.9804080  1
1998 Rahman I, Bel A, Mulier B, Donaldson K, MacNee W. Differential regulation of glutathione by oxidants and dexamethasone in alveolar epithelial cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 275: L80-L86. PMID 29592037 DOI: 10.1152/ajplung.1998.275.1.L80  1
1998 Rahman I, MacNee W. Role of transcription factors in inflammatory lung diseases. Thorax. 53: 601-12. PMID 9797762  1
1998 Rahman I, Bel A, Mulier B, Donaldson K, MacNee W. Differential regulation of glutathione by oxidants and dexamethasone in alveolar epithelial cells. The American Journal of Physiology. 275: L80-6. PMID 9688938  1
1998 Rahman I, Smith CA, Antonicelli F, MacNee W. Characterisation of gamma-glutamylcysteine synthetase-heavy subunit promoter: a critical role for AP-1. Febs Letters. 427: 129-33. PMID 9613613 DOI: 10.1016/S0014-5793(98)00410-4  1
1998 Mulier B, Rahman I, Watchorn T, Donaldson K, MacNee W, Jeffery PK. Hydrogen peroxide-induced epithelial injury: the protective role of intracellular nonprotein thiols (NPSH). The European Respiratory Journal. 11: 384-91. PMID 9551743  1
1997 Gilmour PS, Brown DM, Beswick PH, MacNee W, Rahman I, Donaldson K. Free radical activity of industrial fibers: role of iron in oxidative stress and activation of transcription factors. Environmental Health Perspectives. 105: 1313-7. PMID 9400744  1
1997 Rahman I, Skwarska E, MacNee W. Attenuation of oxidant/antioxidant imbalance during treatment of exacerbations of chronic obstructive pulmonary disease. Thorax. 52: 565-8. PMID 9227727  1
1996 Rahman I, Bel A, Mulier B, Lawson MF, Harrison DJ, Macnee W, Smith CA. Transcriptional regulation of gamma-glutamylcysteine synthetase-heavy subunit by oxidants in human alveolar epithelial cells. Biochemical and Biophysical Research Communications. 229: 832-7. PMID 8954980 DOI: 10.1006/bbrc.1996.1888  1
1996 Rahman I, Smith CA, Lawson MF, Harrison DJ, MacNee W. Induction of gamma-glutamylcysteine synthetase by cigarette smoke is associated with AP-1 in human alveolar epithelial cells. Febs Letters. 396: 21-5. PMID 8906859  1
1996 Rahman I, MacNee W. Role of oxidants/antioxidants in smoking-induced lung diseases. Free Radical Biology & Medicine. 21: 669-81. PMID 8891669  1
1996 Rahman I, Morrison D, Donaldson K, MacNee W. Systemic oxidative stress in asthma, COPD, and smokers. American Journal of Respiratory and Critical Care Medicine. 154: 1055-60. PMID 8887607 DOI: 10.1164/ajrccm.154.4.8887607  1
1996 Rahman I, MacNee W. Oxidant/antioxidant imbalance in smokers and chronic obstructive pulmonary disease. Thorax. 51: 348-50. PMID 8733482  1
1996 Li XY, Rahman I, Donaldson K, MacNee W. Mechanisms of cigarette smoke induced increased airspace permeability. Thorax. 51: 465-71. PMID 8711672  1
1996 MacNee W, Morrison D, Rahman I, Li XY, Donaldson K. Cigarette smoke and ozone-induced epithelial perturbation in vivo and in vitro. The role of glutathione. Chest. 109: 39S. PMID 8598146  1
1995 Rahman I, Li XY, Donaldson K, Macnee W. Cigarette smoke, glutathione metabolism and epithelial permeability in rat lungs. Biochemical Society Transactions. 23: 235S. PMID 7672256  1
1995 Rahman I, Li XY, Donaldson K, Harrison DJ, MacNee W. Glutathione homeostasis in alveolar epithelial cells in vitro and lung in vivo under oxidative stress. The American Journal of Physiology. 269: L285-92. PMID 7573460 DOI: 10.1152/ajplung.1995.269.3.L285  1
1995 MacNee W, Rahman I. Oxidants/antioxidants in idiopathic pulmonary fibrosis. Thorax. 50: S53-8. PMID 7570466  1
1994 Li XY, Donaldson K, Rahman I, MacNee W. An investigation of the role of glutathione in increased epithelial permeability induced by cigarette smoke in vivo and in vitro. American Journal of Respiratory and Critical Care Medicine. 149: 1518-25. PMID 8004308 DOI: 10.1164/ajrccm.149.6.8004308  1
1992 Rahman IU, Massaro GD, Massaro D. Exposure of rats to ozone: Evidence of damage to heart and brain Free Radical Biology and Medicine. 12: 323-326. PMID 1577334 DOI: 10.1016/0891-5849(92)90119-2  1
1992 Rahman Iu, Massaro D. Endotoxin treatment protects rats against ozone-induced lung edema: With evidence for the role of manganese superoxide dismutase Toxicology and Applied Pharmacology. 113: 13-18. PMID 1553746 DOI: 10.1016/0041-008X(92)90003-B  1
1991 Rahman IU, Clerch LB, Massaro D. Rat lung antioxidant enzyme induction by ozone American Journal of Physiology - Lung Cellular and Molecular Physiology. 260. PMID 2058686  1
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