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Robin L. Polt, Ph.D. - Publications

Chemistry and Biochemistry University of Arizona, Tucson, AZ 
Organic Synthesis

71 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Palos Pacheco R, Eismin RJ, Coss CS, Wang H, Maier RM, Polt R, Pemberton JE. Synthesis and Characterization of Four Diastereomers of Monorhamnolipids. Journal of the American Chemical Society. PMID 28301722 DOI: 10.1021/jacs.7b00427  0.48
2016 Szabó LZ, Hanrahan DJ, Jones EM, Martin E, Pemberton JE, Polt R. Preparation of S-glycoside surfactants and cysteine thioglycosides using minimally competent Lewis acid catalysis. Carbohydrate Research. 422: 1-4. PMID 26795078 DOI: 10.1016/j.carres.2015.12.008  0.92
2016 Kegel LL, Szabó LZ, Polt R, Pemberton JE. Alkyl melibioside and alkyl cellobioside surfactants: Effect of sugar headgroup and alkyl chain length on performance Green Chemistry. 18: 4446-4460. DOI: 10.1039/c6gc00436a  0.48
2015 Lefever M, Li Y, Anglin B, Muthu D, Giuvelis D, Lowery JJ, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. Structural Requirements for CNS Active Opioid Glycopeptides. Journal of Medicinal Chemistry. 58: 5728-41. PMID 26125201 DOI: 10.1021/acs.jmedchem.5b00014  0.92
2015 Stevenson GW, Luginbuhl A, Dunbar C, LaVigne J, Dutra J, Atherton P, Bell B, Cone K, Giuvelis D, Polt R, Streicher JM, Bilsky EJ. The mixed-action delta/mu opioid agonist MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependence. Pharmacology, Biochemistry, and Behavior. 132: 49-55. PMID 25735493 DOI: 10.1016/j.pbb.2015.02.022  0.92
2014 Li Y, St Louis L, Knapp BI, Muthu D, Anglin B, Giuvelis D, Bidlack JM, Bilsky EJ, Polt R. Can amphipathic helices influence the CNS antinociceptive activity of glycopeptides related to β-endorphin? Journal of Medicinal Chemistry. 57: 2237-46. PMID 24576160 DOI: 10.1021/jm400879w  0.92
2013 Wang H, Coss CS, Mudalige A, Polt RL, Pemberton JE. A PM-IRRAS investigation of monorhamnolipid orientation at the air-water interface. Langmuir : the Acs Journal of Surfaces and Colloids. 29: 4441-50. PMID 23406083 DOI: 10.1021/la3051725  0.92
2012 Mabrouk OS, Falk T, Sherman SJ, Kennedy RT, Polt R. CNS penetration of the opioid glycopeptide MMP-2200: a microdialysis study. Neuroscience Letters. 531: 99-103. PMID 23127847 DOI: 10.1016/j.neulet.2012.10.029  0.92
2012 Lefever MR, Szabò LZ, Anglin B, Ferracane M, Hogan J, Cooney L, Polt R. Glycosylation of α-amino acids by sugar acetate donors with InBr3. Minimally competent Lewis acids. Carbohydrate Research. 351: 121-5. PMID 22342206 DOI: 10.1016/j.carres.2012.01.008  0.92
2012 Li Y, Lefever MR, Muthu D, Bidlack JM, Bilsky EJ, Polt R. Opioid glycopeptide analgesics derived from endogenous enkephalins and endorphins. Future Medicinal Chemistry. 4: 205-26. PMID 22300099 DOI: 10.4155/fmc.11.195  0.92
2012 Coss C, Carrocci T, Maier RM, Pemberton JE, Polt R. Minimally competent lewis acid catalysts: Indium(III) and bismuth(III) salts produce rhamnosides (=6-deoxymannosides) in high yield and purity Helvetica Chimica Acta. 95: 2652-2659. DOI: 10.1002/hlca.201200528  0.92
2011 Yue X, Falk T, Zuniga LA, Szabò L, Porreca F, Polt R, Sherman SJ. Effects of the novel glycopeptide opioid agonist MMP-2200 in preclinical models of Parkinson's disease. Brain Research. 1413: 72-83. PMID 21840512 DOI: 10.1016/j.brainres.2011.07.038  0.92
2011 Yeomans L, Muthu D, Lowery JJ, Martinez HN, Abrell L, Lin G, Strom K, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. Phosphorylation of enkephalins: NMR and CD studies in aqueous and membrane-mimicking environments. Chemical Biology & Drug Design. 78: 749-56. PMID 21801311 DOI: 10.1111/j.1747-0285.2011.01203.x  0.92
2011 Lowery JJ, Raymond TJ, Giuvelis D, Bidlack JM, Polt R, Bilsky EJ. In vivo characterization of MMP-2200, a mixed δ/μ opioid agonist, in mice. The Journal of Pharmacology and Experimental Therapeutics. 336: 767-78. PMID 21118955 DOI: 10.1124/jpet.110.172866  0.92
2010 Keyari CM, Polt R, Nichol GS. (S)-Methyl 2-{(S)-2-[bis-(4-meth-oxy-phen-yl)methyl-idene-amino]-3-hy-droxy-propanamido}-3-methyl-butano-ate. Acta Crystallographica. Section E, Structure Reports Online. 67: o13-4. PMID 21522640 DOI: 10.1107/S1600536810049032  0.92
2010 Keyari CM, Polt R. Serine and threonine Schiff base esters react with β-anomeric peracetates in the presence of BF3·Et2O to produce β-glycosides Journal of Carbohydrate Chemistry. 29: 181-206. DOI: 10.1080/07328303.2010.508295  0.92
2009 Keyari CM, Knapp BI, Bidlack JM, Lowey J, Bilsky EJ, Polt R. Glycosyl-enkephalins: synthesis and binding at the mu, delta & kappa opioid receptors. Antinociception in mice. Advances in Experimental Medicine and Biology. 611: 495-6. PMID 19400281 DOI: 10.1007/978-0-387-73657-0_214  0.92
2008 Do Carmo GP, Polt R, Bilsky EJ, Rice KC, Negus SS. Behavioral pharmacology of the mu/delta opioid glycopeptide MMP2200 in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 326: 939-48. PMID 18511649 DOI: 10.1124/jpet.108.138180  0.92
2008 Abeytunga DTU, Oland L, Somogyi A, Polt R. Structural studies on the neutral glycosphingolipids of Manduca sexta Bioorganic Chemistry. 36: 70-76. PMID 18023840 DOI: 10.1016/j.bioorg.2007.10.002  0.92
2007 Jalbout AF, Abrell L, Adamowicz L, Polt R, Apponi AJ, Ziurys LM. Sugar synthesis from a gas-phase formose reaction. Astrobiology. 7: 433-42. PMID 17630839 DOI: 10.1089/ast.2006.0083  0.92
2007 Lowery JJ, Yeomans L, Keyari CM, Davis P, Porreca F, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. Glycosylation improves the central effects of DAMGO. Chemical Biology & Drug Design. 69: 41-7. PMID 17313456 DOI: 10.1111/j.1747-0285.2007.00462.x  0.92
2006 Halfen DT, Apponi AJ, Woolf N, Polt R, Ziurys LM. A systematic study of glycolaldehyde in sagittarius B2(N) at 2 and 3 mm: Criteria for detecting large interstellar molecules Astrophysical Journal. 639: 237-245. DOI: 10.1086/499225  0.92
2005 Dhanasekaran M, Polt R. New prospects for glycopeptide based analgesia: glycoside-induced penetration of the blood-brain barrier. Current Drug Delivery. 2: 59-73. PMID 16305409 DOI: 10.2174/1567201052772843  0.92
2005 Polt R, Dhanasekaran M, Keyari CM. Glycosylated neuropeptides: a new vista for neuropsychopharmacology? Medicinal Research Reviews. 25: 557-85. PMID 16075406 DOI: 10.1002/med.20039  0.92
2005 Dhanasekaran M, Palian MM, Alves I, Yeomans L, Keyari CM, Davis P, Bilsky EJ, Egleton RD, Yamamura HI, Jacobsen NE, Tollin G, Hruby VJ, Porreca F, Polt R. Glycopeptides related to beta-endorphin adopt helical amphipathic conformations in the presence of lipid bilayers. Journal of the American Chemical Society. 127: 5435-48. PMID 15826181 DOI: 10.1021/ja0432158  0.92
2005 Egleton RD, Bilsky EJ, Tollin G, Dhanasekaran M, Lowery J, Alves I, Davis P, Porreca F, Yamamura HI, Yeomans L, Keyari CM, Polt R. Biousian glycopeptides penetrate the blood-brain barrier Tetrahedron Asymmetry. 16: 65-75. DOI: 10.1016/j.tetasy.2004.11.038  0.92
2004 Elmagbari NO, Egleton RD, Palian MM, Lowery JJ, Schmid WR, Davis P, Navratilova E, Dhanasekaran M, Keyari CM, Yamamura HI, Porreca F, Hruby VJ, Polt R, Bilsky EJ. Antinociceptive structure-activity studies with enkephalin-based opioid glycopeptides. The Journal of Pharmacology and Experimental Therapeutics. 311: 290-7. PMID 15166257 DOI: 10.1124/jpet.104.069393  0.92
2004 Abeytunga DT, Glick JJ, Gibson NJ, Oland LA, Somogyi A, Wysocki VH, Polt R. Presence of unsaturated sphingomyelins and changes in their composition during the life cycle of the moth Manduca sexta. Journal of Lipid Research. 45: 1221-31. PMID 15102888 DOI: 10.1194/jlr.M300392-JLR200  0.92
2004 Slavish JP, Friel DK, Oland LA, Polt R. New PDMP analogues inhibit process outgrowth in an insect cell line. Bioorganic & Medicinal Chemistry Letters. 14: 1487-90. PMID 15006387 DOI: 10.1002/chin.200430153  0.92
2003 Palian MM, Boguslavsky VI, O'Brien DF, Polt R. Glycopeptide-membrane interactions: glycosyl enkephalin analogues adopt turn conformations by NMR and CD in amphipathic media. Journal of the American Chemical Society. 125: 5823-31. PMID 12733923 DOI: 10.1021/ja0268635  0.92
2003 Polt R, Kelly BD, Dangel BD, Tadikonda UB, Ross RE, Raitsimring AM, Astashkin AV. Optically active 4- and 5-coordinate transition metal complexes of bifurcated dipeptide Schiff bases. Inorganic Chemistry. 42: 566-74. PMID 12693240 DOI: 10.1021/ic025996o  0.92
2001 Egleton RD, Mitchell SA, Huber JD, Palian MM, Polt R, Davis TP. Improved blood-brain barrier penetration and enhanced analgesia of an opioid peptide by glycosylation. The Journal of Pharmacology and Experimental Therapeutics. 299: 967-72. PMID 11714884  0.92
2001 Palian MM, Polt R. Lipo alpha-amino-beta-hydroxy acids and O-linked glycosides: building blocks for ceramyl and glycosphingoyl peptides. The Journal of Organic Chemistry. 66: 7178-83. PMID 11597248 DOI: 10.1021/jo015844v  0.92
2001 Palian MM, Jacobsen NE, Polt R. O-Linked glycopeptides retain helicity in water. The Journal of Peptide Research : Official Journal of the American Peptide Society. 58: 180-9. PMID 11532077 DOI: 10.1034/j.1399-3011.2001.00906.x  0.92
2001 Mitchell SA, Pratt MR, Hruby VJ, Polt R. Solid-phase synthesis of O-linked glycopeptide analogues of enkephalin Journal of Organic Chemistry. 66: 2327-2342. PMID 11281773 DOI: 10.1021/jo005712m  0.92
2001 Polt R, Palian MM. Glycopeptide analgesics Drugs of the Future. 26: 561-576. DOI: 10.1358/dof.2001.026.06.668342  0.92
2000 Egleton RD, Mitchell SA, Huber JD, Janders J, Stropova D, Polt R, Yamamura HI, Hruby VJ, Davis TP. Improved bioavailability to the brain of glycosylated Met-enkephalin analogs. Brain Research. 881: 37-46. PMID 11033091 DOI: 10.1016/S0006-8993(00)02794-3  0.92
2000 Dangel BD, Polt R. Catalysis by amino acid-derived tetracoordinate complexes: enantioselective addition of dialkylzincs to aliphatic and aromatic aldehydes. Organic Letters. 2: 3003-6. PMID 10986093  0.92
2000 Razavi H, Polt R. Asymmetric syntheses of (-)-8-epi-swainsonine triacetate and (+)-1,2-di-epi-swainsonine. Carbonyl addition thwarted by an unprecedented aza-pinacol rearrangement Journal of Organic Chemistry. 65: 5693-5706. PMID 10970313 DOI: 10.1021/jo000527u  0.92
2000 Bilsky EJ, Egleton RD, Mitchell SA, Palian MM, Davis P, Huber JD, Jones H, Yamamura HI, Janders J, Davis TP, Porreca F, Hruby VJ, Polt R. Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability. Journal of Medicinal Chemistry. 43: 2586-90. PMID 10891118 DOI: 10.1021/jm000077y  0.92
2000 Kriss CT, Lou BS, Szabò LZ, Mitchell SA, Hruby VJ, Polt R. Enkephalin-based drug design: Conformational analysis of O-linked glycopeptides by NMR and molecular modeling Tetrahedron Asymmetry. 11: 9-25. DOI: 10.1016/S0957-4166(99)00544-3  0.92
1999 Polt R, Sames D, Chruma J. Glycosidase inhibitors: Synthesis of enantiomerically pure aza-sugars from Schiff base amino esters via tandem reduction-alkenylation and osmylation Journal of Organic Chemistry. 64: 6147-6158. DOI: 10.1021/jo9820115  0.92
1998 Mitchell SA, Oates BD, Razavi H, Polt R. Glycosyltransferase inhibitors: Synthesis of D-threo-PDMP, L-threo- PDMP, and other brain glucosylceramide synthase inhibitors from D- or L- serine Journal of Organic Chemistry. 63: 8837-8842. DOI: 10.1021/jo980951j  0.92
1998 Razavi H, Polt R. Syntheses of iminolyxitols via tandem reduction-alkenylation of O'Donnell's Schiff bases Tetrahedron Letters. 39: 3371-3374. DOI: 10.1016/S0040-4039(98)00495-X  0.92
1997 Dangel B, Clarke M, Haley J, Sames D, Polt R. Amino acid-derived ligands for transition metals: Catalysis via a minimalist interpretation of a metalloprotein Journal of the American Chemical Society. 119: 10865-10866. DOI: 10.1021/ja972135j  0.92
1997 Chruma JJ, Sames D, Polt R. General method for the synthesis of N-methyl amino acids and N-alkyl amino esters from O'Donnell's Schiff bases Tetrahedron Letters. 38: 5085-5086. DOI: 10.1016/S0040-4039(97)01132-5  0.92
1996 Polt RL, Szabo L, Ramza J. [New chemical method for synthesis of O-linked glycopeptides]. PostȩPy Higieny I Medycyny DośWiadczalnej. 50: 493-503. PMID 9072765  0.92
1995 Szabó L, Ramza J, Langdon C, Polt R. Stereoselective synthesis of O-serinyl/threoninyl-2-acetamido-2-deoxy-α- or β-glycosides Carbohydrate Research. 274: 11-28. PMID 7585702 DOI: 10.1016/0008-6215(95)00016-M  0.92
1995 Sames D, Liu Y, DeYoung L, Polt R. Preparation of monosilyl acetals from esters via iBu2AlH reduction and trapping with N-(trimethylsilyl)imidazole. Addition of allyltrimethylsilane to yield homoallylic alcohols or ethers Journal of Organic Chemistry. 60: 2153-2159.  0.92
1994 Polt R, Porreca F, Szabò LZ, Bilsky EJ, Davis P, Abbruscato TJ, Davis TP, Harvath R, Yamamura HI, Hruby VJ. Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier. Proceedings of the National Academy of Sciences of the United States of America. 91: 7114-8. PMID 8041755 DOI: 10.1073/pnas.91.15.7114  0.92
1994 Szabó L, Polt R. Stereoselective synthesis of β-d-glycopyranosyl-l-serinate or -threoninate derivatives with an unusual migration Carbohydrate Research. 258: 293-297. PMID 8039183 DOI: 10.1016/0008-6215(94)84096-2  0.92
1994 Hruby VJ, Misicka A, Lipkowski AW, Haaseth R, Bartosz H, Qian X, Collins N, Meyer JP, Szabo L, Polt R, Porreca F, Davis T, Yamamura HI. New opioid compounds in analgesia Regulatory Peptides. 53: S71-S72. DOI: 10.1016/0167-0115(94)90246-1  0.92
1994 Sames D, Polt R. An enantioselective synthesis of N-methylfucosamine via tandem C-C/C-O bond formation Journal of Organic Chemistry. 59: 4596-4601.  0.92
1993 Weber SJ, Abbruscato TJ, Brownson EA, Lipkowski AW, Polt R, Misicka A, Haaseth RC, Bartosz H, Hruby VJ, Davis TP. Assessment of an in vitro blood-brain barrier model using several [Met5]enkephalin opioid analogs. The Journal of Pharmacology and Experimental Therapeutics. 266: 1649-55. PMID 8371162  0.92
1993 Maiorino RM, Aposhian MM, Xu ZF, Li Y, Polt RL, Aposhian HV. Determination and metabolism of dithiol chelating agents. XV. The meso-2,3-dimercaptosuccinic acid-cysteine (1:2) mixed disulfide, a major urinary metabolite of DMSA in the human, increases the urinary excretion of lead in the rat. The Journal of Pharmacology and Experimental Therapeutics. 267: 1221-6. PMID 8263783  0.92
1993 Peterson MA, Polt R. N-diphenylmethylene-protected glycosyl acceptors. Selective β-O-glycosylation to form lactosyl-threo-ceramides Journal of Organic Chemistry. 58: 4309-4314.  0.92
1992 Peterson MA, Polt R. E-1-Lithio-1-Alkenes in Hydrocarbon Solvent Synthetic Communications. 22: 477-480. DOI: 10.1080/00397919208055426  0.92
1992 Polt R, Li Y, Fernando Q, Rivera M. A synthetic method for unsymmetrical disulfides of cysteine: the bis-cysteine disulfide of meso-2,3-dimercaptosuccinic acid. Tetrahedron Letters. 33: 2961-2964. DOI: 10.1016/S0040-4039(00)79572-4  0.92
1992 Polt R, Peterson MA, Deyoung L. Aluminoxy acetals from α-amino esters: Chirality transfer via sequential addition of hydride and C-nucleophiles. 2-Amino alcohols and sphingosines Journal of Organic Chemistry. 57: 5469-5480.  0.92
1992 Polt R, Szabó L, Treiberg J, Li Y, Hruby VJ. General methods for α- Or β-O-Ser/Thr glycosides and glycopeptides. Solid-phase synthesis of O-glycosyl cyclic enkephalin analogues Journal of the American Chemical Society. 114: 10249-10258.  0.92
1991 Polt R, Wijayarathe T. Erythrose sesqui-acetals as electrophiles. 2-Deoxy-C-nucleosides from D-glucose Tetrahedron Letters. 32: 4831-4834. DOI: 10.1016/S0040-4039(00)93472-5  0.92
1991 Szabò L, Li Y, Polt R. O-glycopeptides: a simple β-stereoselective glycosidation of serine and threonine via a favorable hydrogen bonding pattern Tetrahedron Letters. 32: 585-588. DOI: 10.1016/S0040-4039(00)74833-7  0.92
1990 Polt R, Peterson MA. β-Amino alcohols from amino acids: Chelation control via schiff bases Tetrahedron Letters. 31: 4985-4986. DOI: 10.1016/S0040-4039(00)97784-0  0.92
1989 Polt R, Seebach D. Stereoselective alkylation of glycine units in dipeptide derivatives: "Chirality transfer" via a pivalaldehyde N,N-acetal center Journal of the American Chemical Society. 111: 2622-2632.  0.92
1988 Stork G, Polt RL, Li Y, Houk KN. Theoretical studies of the lithiation of enamines Journal of the American Chemical Society. 110: 8360-8367. DOI: 10.1021/ja00233a013  0.92
1988 O'Donnell MJ, Bennett WD, Bruder WA, Jacobsen WN, Knuth K, LeClef B, Polt RL, Bordwell FG, Mrozack SR, Cripe TA. Acidities of glycine Schiff bases and alkylation of their conjugate bases Journal of the American Chemical Society. 110: 8520-8525.  0.92
1986 Stork G, Shiner CS, Cheng CW, Polt RL. Deprotonation of chelating enamines. Direct formation of .beta.-lithio enamines Journal of the American Chemical Society. 108: 304-305. DOI: 10.1021/ja00262a025  0.72
1986 Stork G, Shiner CS, Cheng CW, Polt RL. Deprotonation of chelating enamines. Direct formation of β-lithio enamines Journal of the American Chemical Society. 108: 304-305.  0.92
1985 O'Donnell MJ, Bennett WD, Polt RL. Preparation of an electrophilic glycine cation equivalent and its reaction with heteroatom nucleophiles Tetrahedron Letters. 26: 695-698. DOI: 10.1016/S0040-4039(00)89111-X  0.92
1984 Polt RL, Stork G, Carpenter GB, Williard PG. X-ray crystal structure of N-(2-lithiocyclohexenyl)-N,N′,N′-trimethyl-1,3-propanediamine: A pentavalent lithium? Journal of the American Chemical Society. 106: 4276-4277. DOI: 10.1021/ja00327a041  0.92
1982 O'Donnell MJ, Polt RL. A mild and efficient route to Schiff base derivatives of amino acids Journal of Organic Chemistry. 47: 2663-2666.  0.92
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