Brent R. Stockwell - Publications

Affiliations: 
Chemistry Columbia University, New York, NY 
Area:
to identify compounds and proteins that act as critical regulators of cancer and neurodegeneration
Website:
http://www.columbia.edu/cu/biology/faculty/stockwell/StockwellLab/index/pi-biography.html

93 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Zhang Y, Tan H, Daniels JD, Zandkarimi F, Liu H, Brown LM, Uchida K, O'Connor OA, Stockwell BR. Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model. Cell Chemical Biology. PMID 30799221 DOI: 10.1016/j.chembiol.2019.01.008  0.6
2018 Gaschler MM, Andia AA, Liu H, Csuka JM, Hurlocker B, Vaiana CA, Heindel DW, Zuckerman DS, Bos PH, Reznik E, Ye LF, Tyurina YY, Lin AJ, Shchepinov MS, Chan AY, ... ... Stockwell BR, et al. FINOinitiates ferroptosis through GPX4 inactivation and iron oxidation. Nature Chemical Biology. PMID 29610484 DOI: 10.1038/s41589-018-0031-6  0.6
2018 Liu H, Schreiber SL, Stockwell BR. Targeting Dependency on the GPX4 Lipid Peroxide Repair Pathway for Cancer Therapy. Biochemistry. PMID 29584411 DOI: 10.1021/acs.biochem.8b00307  0.96
2017 Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Aguirre AJ, Viswanathan SR, Chattopadhyay S, Tamayo P, Yang WS, Rees MG, ... ... Stockwell BR, et al. Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway. Nature. PMID 28678785 DOI: 10.1038/nature23007  0.96
2017 Welsch ME, Kaplan A, Chambers JM, Stokes ME, Bos PH, Zask A, Zhang Y, Sanchez-Martin M, Badgley MA, Huang CS, Tran TH, Akkiraju H, Brown LM, Nandakumar R, Cremers S, ... ... Stockwell BR, et al. Multivalent Small-Molecule Pan-RAS Inhibitors. Cell. 168: 878-889.e29. PMID 28235199 DOI: 10.1016/j.cell.2017.02.006  0.36
2016 Yang WS, Kim KJ, Gaschler MM, Patel M, Shchepinov MS, Stockwell BR. Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 27506793 DOI: 10.1073/pnas.1603244113  0.96
2016 Gerhard DS, Clemons PA, Shamji AF, Hon C, Wagner BK, Schreiber SL, Krasnitz A, Sordella R, Sander C, Lowe SW, Powers S, Smith K, Aburi M, Iavarone A, Lasorella A, ... ... Stockwell BR, et al. Transforming Big Data into cancer-relevant insight: An initial, multi-tier approach to assess reproducibility and relevance. Molecular Cancer Research : McR. PMID 27401613 DOI: 10.1158/1541-7786.MCR-16-0090  0.96
2016 Shimada K, Skouta R, Kaplan A, Yang WS, Hayano M, Dixon SJ, Brown LM, Valenzuela CA, Wolpaw AJ, Stockwell BR. Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis. Nature Chemical Biology. PMID 27159577 DOI: 10.1038/nchembio.2079  0.96
2016 Shimada K, Hayano M, Pagano NC, Stockwell BR. Cell-Line Selectivity Improves the Predictive Power of Pharmacogenomic Analyses and Helps Identify NADPH as Biomarker for Ferroptosis Sensitivity. Cell Chemical Biology. PMID 26853626 DOI: 10.1016/j.chembiol.2015.11.016  0.96
2015 Yang WS, Stockwell BR. Ferroptosis: Death by Lipid Peroxidation. Trends in Cell Biology. PMID 26653790 DOI: 10.1016/j.tcb.2015.10.014  0.96
2015 Stockwell BR, Stockwell MS, Cennamo M, Jiang E. Blended Learning Improves Science Education. Cell. 162: 933-6. PMID 26317458 DOI: 10.1016/j.cell.2015.08.009  0.96
2015 Larraufie MH, Yang WS, Jiang E, Thomas AG, Slusher BS, Stockwell BR. Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility. Bioorganic & Medicinal Chemistry Letters. 25: 4787-92. PMID 26231156 DOI: 10.1016/j.bmcl.2015.07.018  0.96
2015 Dixon SJ, Winter GE, Musavi LS, Lee ED, Snijder B, Rebsamen M, Superti-Furga G, Stockwell BR. Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death. Acs Chemical Biology. PMID 25965523 DOI: 10.1021/acschembio.5b00245  0.96
2015 Kaplan A, Gaschler MM, Dunn DE, Colligan R, Brown LM, Palmer AG, Lo DC, Stockwell BR. Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective. Proceedings of the National Academy of Sciences of the United States of America. 112: E2245-52. PMID 25848045 DOI: 10.1073/pnas.1500439112  0.96
2015 Quartararo CE, Reznik E, DeCarvalho AC, Mikkelsen T, Stockwell BR. High-Throughput Screening of Patient-Derived Cultures Reveals Potential for Precision Medicine in Glioblastoma Acs Medicinal Chemistry Letters. 6: 948-952. DOI: 10.1021/acsmedchemlett.5b00128  0.96
2015 Kaplan A, Stockwell BR. Structural elucidation of a small molecule inhibitor of protein disulfide isomerase Acs Medicinal Chemistry Letters. 6: 966-971. DOI: 10.1021/acsmedchemlett.5b00014  0.96
2015 Woo JH, Shimoni Y, Yang WS, Subramaniam P, Iyer A, Nicoletti P, Rodríguez Martínez M, López G, Mattioli M, Realubit R, Karan C, Stockwell BR, Bansal M, Califano A. Elucidating Compound Mechanism of Action by Network Perturbation Analysis Cell. 162: 441-451. DOI: 10.1016/j.cell.2015.05.056  0.96
2014 Linkermann A, Skouta R, Himmerkus N, Mulay SR, Dewitz C, De Zen F, Prokai A, Zuchtriegel G, Krombach F, Welz PS, Weinlich R, Vanden Berghe T, Vandenabeele P, Pasparakis M, Bleich M, ... ... Stockwell BR, et al. Synchronized renal tubular cell death involves ferroptosis. Proceedings of the National Academy of Sciences of the United States of America. 111: 16836-41. PMID 25385600 DOI: 10.1073/pnas.1415518111  0.96
2014 Linkermann A, Stockwell BR, Krautwald S, Anders HJ. Regulated cell death and inflammation: an auto-amplification loop causes organ failure. Nature Reviews. Immunology. 14: 759-67. PMID 25324125 DOI: 10.1038/nri3743  0.96
2014 Julien O, Kampmann M, Bassik MC, Zorn JA, Venditto VJ, Shimbo K, Agard NJ, Shimada K, Rheingold AL, Stockwell BR, Weissman JS, Wells JA. Unraveling the mechanism of cell death induced by chemical fibrils. Nature Chemical Biology. 10: 969-76. PMID 25262416 DOI: 10.1038/nchembio.1639  0.96
2014 Wolpaw AJ, Stockwell BR. Multidimensional profiling in the investigation of small-molecule-induced cell death. Methods in Enzymology. 545: 265-302. PMID 25065894 DOI: 10.1016/B978-0-12-801430-1.00011-1  0.96
2014 Cantley AM, Welsch M, Ambesi-Impiombato A, Sanchez-Martin M, Kim MY, Bauer A, Ferrando A, Stockwell BR. Small Molecule that Reverses Dexamethasone Resistance in T-cell Acute Lymphoblastic Leukemia (T-ALL). Acs Medicinal Chemistry Letters. 5: 754-9. PMID 25050160 DOI: 10.1021/ml500044g  0.96
2014 Dixon SJ, Patel DN, Welsch M, Skouta R, Lee ED, Hayano M, Thomas AG, Gleason CE, Tatonetti NP, Slusher BS, Stockwell BR. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. Elife. 3: e02523. PMID 24844246 DOI: 10.7554/eLife.02523  0.96
2014 Skouta R, Dixon SJ, Wang J, Dunn DE, Orman M, Shimada K, Rosenberg PA, Lo DC, Weinberg JM, Linkermann A, Stockwell BR. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. Journal of the American Chemical Society. 136: 4551-6. PMID 24592866 DOI: 10.1021/ja411006a  0.96
2014 Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, Stockwell BR. Regulation of ferroptotic cancer cell death by GPX4. Cell. 156: 317-31. PMID 24439385 DOI: 10.1016/j.cell.2013.12.010  0.96
2014 Dixon SJ, Stockwell BR. The role of iron and reactive oxygen species in cell death. Nature Chemical Biology. 10: 9-17. PMID 24346035 DOI: 10.1038/nchembio.1416  0.96
2013 Basu A, Bodycombe NE, Cheah JH, Price EV, Liu K, Schaefer GI, Ebright RY, Stewart ML, Ito D, Wang S, Bracha AL, Liefeld T, Wawer M, Gilbert JC, Wilson AJ, ... ... Stockwell BR, et al. An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules. Cell. 154: 1151-61. PMID 23993102 DOI: 10.1016/j.cell.2013.08.003  0.96
2013 Varma H, Gangadhar NM, Letso RR, Wolpaw AJ, Sriramaratnam R, Stockwell BR. Identification of a small molecule that induces ATG5-and-cathepsin-l-dependent cell death and modulates polyglutamine toxicity. Experimental Cell Research. 319: 1759-73. PMID 23588206 DOI: 10.1016/j.yexcr.2013.03.019  0.96
2013 Letso RR, Bauer AJ, Lunn MR, Yang WS, Stockwell BR. Small molecule screen reveals regulation of survival motor neuron protein abundance by Ras proteins. Acs Chemical Biology. 8: 914-22. PMID 23496866 DOI: 10.1021/cb300374h  0.96
2012 Kosuri P, Alegre-Cebollada J, Feng J, Kaplan A, Inglés-Prieto A, Badilla CL, Stockwell BR, Sanchez-Ruiz JM, Holmgren A, Fernández JM. Protein folding drives disulfide formation. Cell. 151: 794-806. PMID 23141538 DOI: 10.1016/j.cell.2012.09.036  0.96
2012 Kaplan A, Stockwell BR. Therapeutic approaches to preventing cell death in Huntington disease. Progress in Neurobiology. 99: 262-80. PMID 22967354 DOI: 10.1016/j.pneurobio.2012.08.004  0.96
2012 Skouta R, Hayano M, Shimada K, Stockwell BR. Design and synthesis of Pictet-Spengler condensation products that exhibit oncogenic-RAS synthetic lethality and induce non-apoptotic cell death. Bioorganic & Medicinal Chemistry Letters. 22: 5707-13. PMID 22832321 DOI: 10.1016/j.bmcl.2012.06.077  0.96
2012 Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B, Stockwell BR. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 149: 1060-72. PMID 22632970 DOI: 10.1016/j.cell.2012.03.042  0.96
2012 Weïwer M, Bittker JA, Lewis TA, Shimada K, Yang WS, MacPherson L, Dandapani S, Palmer M, Stockwell BR, Schreiber SL, Munoz B. Development of small-molecule probes that selectively kill cells induced to express mutant RAS. Bioorganic & Medicinal Chemistry Letters. 22: 1822-6. PMID 22297109 DOI: 10.1016/j.bmcl.2011.09.047  0.96
2012 Yang WS, Shimada K, Delva D, Patel M, Ode E, Skouta R, Stockwell BR. Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency. Acs Medicinal Chemistry Letters. 3: 35-38. PMID 22247791 DOI: 10.1021/ml200195s  0.96
2011 Herman AG, Hayano M, Poyurovsky MV, Shimada K, Skouta R, Prives C, Stockwell BR. Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay. Cancer Discovery. 1: 312-25. PMID 22586610 DOI: 10.1158/2159-8290.CD-11-0104  0.96
2011 Wolpaw AJ, Shimada K, Skouta R, Welsch ME, Akavia UD, Pe'er D, Shaik F, Bulinski JC, Stockwell BR. Modulatory profiling identifies mechanisms of small molecule-induced cell death. Proceedings of the National Academy of Sciences of the United States of America. 108: E771-80. PMID 21896738 DOI: 10.1073/pnas.1106149108  0.96
2011 Bauer AJ, Gieschler S, Lemberg KM, McDermott AE, Stockwell BR. Functional model of metabolite gating by human voltage-dependent anion channel 2. Biochemistry. 50: 3408-10. PMID 21425834 DOI: 10.1021/bi2003247  0.96
2010 Hoffstrom BG, Kaplan A, Letso R, Schmid RS, Turmel GJ, Lo DC, Stockwell BR. Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins. Nature Chemical Biology. 6: 900-6. PMID 21079601 DOI: 10.1038/nchembio.467  0.96
2010 Varma H, Yamamoto A, Sarantos MR, Hughes RE, Stockwell BR. Mutant huntingtin alters cell fate in response to microtubule depolymerization via the GEF-H1-RhoA-ERK pathway. The Journal of Biological Chemistry. 285: 37445-57. PMID 20858895 DOI: 10.1074/jbc.M110.125542  0.96
2010 Schreiber SL, Shamji AF, Clemons PA, Hon C, Koehler AN, Munoz B, Palmer M, Stern AM, Wagner BK, Powers S, Lowe SW, Guo X, Krasnitz A, Sawey ET, ... ... Stockwell BR, et al. Towards patient-based cancer therapeutics. Nature Biotechnology. 28: 904-6. PMID 20829823 DOI: 10.1038/nbt0910-904  0.96
2010 Dixon SJ, Stockwell BR. Drug discovery: engineering drug combinations. Nature Chemical Biology. 6: 318-9. PMID 20404820 DOI: 10.1038/nchembio.353  0.96
2010 Welsch ME, Snyder SA, Stockwell BR. Privileged scaffolds for library design and drug discovery. Current Opinion in Chemical Biology. 14: 347-61. PMID 20303320 DOI: 10.1016/j.cbpa.2010.02.018  0.96
2009 Dixon SJ, Stockwell BR. Identifying druggable disease-modifying gene products. Current Opinion in Chemical Biology. 13: 549-55. PMID 19740696 DOI: 10.1016/j.cbpa.2009.08.003  0.96
2009 Yen L, Stockwell BR, Mulligan RC. A mammalian cell-based assay for screening inhibitors of RNA cleavage. Methods in Molecular Biology (Clifton, N.J.). 540: 335-47. PMID 19381571 DOI: 10.1007/978-1-59745-558-9_24  0.96
2008 Lehár J, Stockwell BR, Giaever G, Nislow C. Combination chemical genetics. Nature Chemical Biology. 4: 674-81. PMID 18936752 DOI: 10.1038/nchembio.120  0.96
2008 Gangadhar NM, Firestein SJ, Stockwell BR. A novel role for jun N-terminal kinase signaling in olfactory sensory neuronal death. Molecular and Cellular Neurosciences. 38: 518-25. PMID 18571430 DOI: 10.1016/j.mcn.2008.04.013  0.96
2008 Yang WS, Stockwell BR. Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest. Genome Biology. 9: R92. PMID 18518968 DOI: 10.1186/gb-2008-9-6-r92  0.96
2008 Bauer AJ, Stockwell BR. Neurobiological applications of small molecule screening Chemical Reviews. 108: 1774-1786. PMID 18447397 DOI: 10.1021/cr0782372  0.96
2008 Yang WS, Stockwell BR. Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chemistry & Biology. 15: 234-45. PMID 18355723 DOI: 10.1016/j.chembiol.2008.02.010  0.96
2008 Varma H, Lo DC, Stockwell BR. High throughput screening for neurodegeneration and complex disease phenotypes. Combinatorial Chemistry & High Throughput Screening. 11: 238-48. PMID 18336216 DOI: 10.2174/138620708783877753  0.96
2008 Antipova AA, Stockwell BR, Golub TR. Gene expression-based screening for inhibitors of PDGFR signaling. Genome Biology. 9: R47. PMID 18312689 DOI: 10.1186/gb-2008-9-3-r47  0.96
2007 Varma H, Cheng R, Voisine C, Hart AC, Stockwell BR. Inhibitors of metabolism rescue cell death in Huntington's disease models. Proceedings of the National Academy of Sciences of the United States of America. 104: 14525-30. PMID 17726098 DOI: 10.1073/pnas.0704482104  0.96
2007 Yagoda N, von Rechenberg M, Zaganjor E, Bauer AJ, Yang WS, Fridman DJ, Wolpaw AJ, Smukste I, Peltier JM, Boniface JJ, Smith R, Lessnick SL, Sahasrabudhe S, Stockwell BR. RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature. 447: 864-8. PMID 17568748 DOI: 10.1038/nature05859  0.96
2007 Voisine C, Varma H, Walker N, Bates EA, Stockwell BR, Hart AC. Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans. Plos One. 2: e504. PMID 17551584 DOI: 10.1371/journal.pone.0000504  0.96
2007 Lehár J, Zimmermann GR, Krueger AS, Molnar RA, Ledell JT, Heilbut AM, Short GF, Giusti LC, Nolan GP, Magid OA, Lee MS, Borisy AA, Stockwell BR, Keith CT. Chemical combination effects predict connectivity in biological systems. Molecular Systems Biology. 3: 80. PMID 17332758 DOI: 10.1038/msb4100116  0.96
2007 Varma H, Voisine C, DeMarco CT, Cattaneo E, Lo DC, Hart AC, Stockwell BR. Selective inhibitors of death in mutant huntingtin cells. Nature Chemical Biology. 3: 99-100. PMID 17195849 DOI: 10.1038/nchembio852  0.96
2007 Gangadhar NM, Stockwell BR. Chemical genetic approaches to probing cell death. Current Opinion in Chemical Biology. 11: 83-7. PMID 17174591 DOI: 10.1016/j.cbpa.2006.11.033  0.96
2006 Letso RR, Stockwell BR. Chemical biology: renewing embryonic stem cells. Nature. 444: 692-3. PMID 17151647 DOI: 10.1038/444692b  0.96
2006 Herman AG, Stockwell BR. Enzyme annotation with chemical tools. Chemistry & Biology. 13: 1013-4. PMID 17052604 DOI: 10.1016/j.chembiol.2006.10.002  0.96
2006 Desai UA, Pallos J, Ma AA, Stockwell BR, Thompson LM, Marsh JL, Diamond MI. Biologically active molecules that reduce polyglutamine aggregation and toxicity. Human Molecular Genetics. 15: 2114-24. PMID 16720620 DOI: 10.1093/hmg/ddl135  0.96
2006 Moffat J, Grueneberg DA, Yang X, Kim SY, Kloepfer AM, Hinkle G, Piqani B, Eisenhaure TM, Luo B, Grenier JK, Carpenter AE, Foo SY, Stewart SA, Stockwell BR, Hacohen N, et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell. 124: 1283-98. PMID 16564017 DOI: 10.1016/j.cell.2006.01.040  0.96
2006 Yen L, Magnier M, Weissleder R, Stockwell BR, Mulligan RC. Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. Rna (New York, N.Y.). 12: 797-806. PMID 16556935 DOI: 10.1261/rna.2300406  0.96
2006 Smukste I, Bhalala O, Persico M, Stockwell BR. Using small molecules to overcome drug resistance induced by a viral oncogene. Cancer Cell. 9: 133-46. PMID 16473280 DOI: 10.1016/j.ccr.2006.01.012  0.96
2006 Stockwell BR. Preventing protein secretion with chemical glue. Nature Chemical Biology. 2: 7-8. PMID 16408080 DOI: 10.1038/nchembio0106-7  0.96
2005 Lunn MR, Stockwell BR. Chemical genetics and orphan genetic diseases. Chemistry & Biology. 12: 1063-73. PMID 16242649 DOI: 10.1016/j.chembiol.2005.09.005  0.96
2005 Smukste I, Stockwell BR. Advances in chemical genetics. Annual Review of Genomics and Human Genetics. 6: 261-86. PMID 16124862 DOI: 10.1146/annurev.genom.6.080604.162136  0.96
2005 Keith CT, Borisy AA, Stockwell BR. Multicomponent therapeutics for networked systems. Nature Reviews. Drug Discovery. 4: 71-8. PMID 15688074 DOI: 10.1038/nrd1609  0.96
2004 Stockwell BR. Exploring biology with small organic molecules. Nature. 432: 846-54. PMID 15602550 DOI: 10.1038/nature03196  0.96
2004 Kelley BP, Lunn MR, Root DE, Flaherty SP, Martino AM, Stockwell BR. A flexible data analysis tool for chemical genetic screens. Chemistry & Biology. 11: 1495-503. PMID 15556000 DOI: 10.1016/j.chembiol.2004.08.026  0.96
2004 Lunn MR, Root DE, Martino AM, Flaherty SP, Kelley BP, Coovert DD, Burghes AH, Man NT, Morris GE, Zhou J, Androphy EJ, Sumner CJ, Stockwell BR. Indoprofen upregulates the survival motor neuron protein through a cyclooxygenase-independent mechanism. Chemistry & Biology. 11: 1489-93. PMID 15555999 DOI: 10.1016/j.chembiol.2004.08.024  0.96
2004 Bailey SN, Sabatini DM, Stockwell BR. Microarrays of small molecules embedded in biodegradable polymers for use in mammalian cell-based screens. Proceedings of the National Academy of Sciences of the United States of America. 101: 16144-9. PMID 15534212 DOI: 10.1073/pnas.0404425101  0.96
2004 Kelley BP, Yuan B, Lewitter F, Sharan R, Stockwell BR, Ideker T. PathBLAST: a tool for alignment of protein interaction networks. Nucleic Acids Research. 32: W83-8. PMID 15215356 DOI: 10.1093/nar/gkh411  0.96
2004 Stegmaier K, Ross KN, Colavito SA, O'Malley S, Stockwell BR, Golub TR. Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation. Nature Genetics. 36: 257-63. PMID 14770183 DOI: 10.1038/ng1305  0.96
2004 Stockwell BR. The biological magic behind the bullets. Nature Biotechnology. 22: 37-8. PMID 14704700 DOI: 10.1038/nbt0104-37  0.96
2003 Smukste I, Stockwell BR. Restoring functions of tumor suppressors with small molecules. Cancer Cell. 4: 419-20. PMID 14706331 DOI: 10.1016/S1535-6108(03)00307-6  0.96
2003 Root DE, Kelley BP, Stockwell BR. Detecting spatial patterns in biological array experiments. Journal of Biomolecular Screening. 8: 393-8. PMID 14567791 DOI: 10.1177/1087057103254282  0.96
2003 Root DE, Flaherty SP, Kelley BP, Stockwell BR. Biological mechanism profiling using an annotated compound library. Chemistry & Biology. 10: 881-92. PMID 14522058 DOI: 10.1016/j.chembiol.2003.08.009  0.96
2003 Kelley BP, Sharan R, Karp RM, Sittler T, Root DE, Stockwell BR, Ideker T. Conserved pathways within bacteria and yeast as revealed by global protein network alignment. Proceedings of the National Academy of Sciences of the United States of America. 100: 11394-9. PMID 14504397 DOI: 10.1073/pnas.1534710100  0.96
2003 Borisy AA, Elliott PJ, Hurst NW, Lee MS, Lehar J, Price ER, Serbedzija G, Zimmermann GR, Foley MA, Stockwell BR, Keith CT. Systematic discovery of multicomponent therapeutics. Proceedings of the National Academy of Sciences of the United States of America. 100: 7977-82. PMID 12799470 DOI: 10.1073/pnas.1337088100  0.44
2003 Dolma S, Lessnick SL, Hahn WC, Stockwell BR. Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell. 3: 285-96. PMID 12676586 DOI: 10.1016/S1535-6108(03)00050-3  0.96
2002 Stockwell BR. Chemical genetic screening approaches to neurobiology. Neuron. 36: 559-62. PMID 12441046 DOI: 10.1016/S0896-6273(02)01056-5  0.96
2002 Root DE, Kelley BP, Stockwell BR. Global analysis of large-scale chemical and biological experiments. Current Opinion in Drug Discovery & Development. 5: 355-60. PMID 12058610  0.96
2002 Blanchard BJ, Stockwell BR, Ingram VM. Eliminating membrane depolarization caused by the Alzheimer peptide Abeta(1-42, aggr.). Biochemical and Biophysical Research Communications. 293: 1204-8. PMID 12054503 DOI: 10.1016/S0006-291X(02)00290-5  0.96
2000 Stockwell BR. Chemical genetics: ligand-based discovery of gene function. Nature Reviews. Genetics. 1: 116-25. PMID 11253651 DOI: 10.1038/35038557  0.96
2000 Stockwell BR. Frontiers in chemical genetics. Trends in Biotechnology. 18: 449-55. PMID 11058785 DOI: 10.1016/S0167-7799(00)01499-2  0.96
2000 Walters MA, Tan DS, Foley MA, Stockwell BR, Shair MD, Schreiber SL. Synthesis and preliminary evaluation of a library of polycyclic small molecules for use in chemical genetic assays Chemtracts. 13: 268-275. DOI: 10.1021/ja992144n  0.96
2000 Walters MA, Tan DS, Foley MA, Stockwell BR, Shair MD, Schreiber SL. Synthesis and preliminary evaluation of a library of polycyclic small molecules for use in chemical genetic assays Chemtracts. 13: 268-275.  0.96
1999 Stockwell BR, Haggarty SJ, Schreiber SL. High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications. Chemistry & Biology. 6: 71-83. PMID 10021420 DOI: 10.1016/S1074-5521(99)80004-0  0.96
1999 Stockwell BR, Hardwick JS, Tong JK, Schreiber SL. Chemical genetic and genomic approaches reveal a role for copper in specific gene activation [19] Journal of the American Chemical Society. 121: 10662-10663. DOI: 10.1021/ja9921221  0.96
1998 Stockwell BR, Schreiber SL. TGF-beta-signaling with small molecule FKBP12 antagonists that bind myristoylated FKBP12-TGF-beta type I receptor fusion proteins. Chemistry & Biology. 5: 385-95. PMID 9662508  0.96
1998 Stockwell BR, Schreiber SL. Probing the role of homomeric and heteromeric receptor interactions in TGF-beta signaling using small molecule dimerizers. Current Biology : Cb. 8: 761-70. PMID 9651680  0.96
1998 Muzio M, Stockwell BR, Stennicke HR, Salvesen GS, Dixit VM. An induced proximity model for caspase-8 activation. The Journal of Biological Chemistry. 273: 2926-30. PMID 9446604 DOI: 10.1074/jbc.273.5.2926  0.96
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