| Year |
Citation |
Score |
| 2021 |
Vaughn A, DeHoog RJ, Eberlin LS, Appling DR. Metabotype analysis of Mthfd1l-null mouse embryos using desorption electrospray ionization mass spectrometry imaging. Analytical and Bioanalytical Chemistry. PMID 33829277 DOI: 10.1007/s00216-021-03308-5 |
0.344 |
|
| 2019 |
Shin M, Vaughn A, Momb J, Appling DR. Deletion of neural tube defect-associated gene Mthfd1l causes reduced cranial mesenchyme density. Birth Defects Research. PMID 31518072 DOI: 10.1002/Bdr2.1591 |
0.341 |
|
| 2018 |
Bryant JD, Sweeney SR, Sentandreu E, Shin M, Ipas H, Xhemalce B, Momb J, Tiziani S, Appling DR. Deletion of the neural tube defect-associated genedisrupts one-carbon and central energy metabolism in mouse embryos. The Journal of Biological Chemistry. PMID 29483189 DOI: 10.1074/Jbc.Ra118.002180 |
0.504 |
|
| 2017 |
Shin M, Momb J, Appling DR. Human mitochondrial MTHFD2 is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase. Cancer & Metabolism. 5: 11. PMID 29225823 DOI: 10.1186/S40170-017-0173-0 |
0.514 |
|
| 2014 |
Momb J, Appling DR. Mitochondrial one-carbon metabolism and neural tube defects. Birth Defects Research. Part a, Clinical and Molecular Teratology. 100: 576-83. PMID 24985542 DOI: 10.1002/Bdra.23268 |
0.355 |
|
| 2014 |
Shin M, Bryant JD, Momb J, Appling DR. Mitochondrial MTHFD2L is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase expressed in both adult and embryonic tissues. The Journal of Biological Chemistry. 289: 15507-17. PMID 24733394 DOI: 10.1074/Jbc.M114.555573 |
0.473 |
|
| 2013 |
Momb J, Lewandowski JP, Bryant JD, Fitch R, Surman DR, Vokes SA, Appling DR. Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice. Proceedings of the National Academy of Sciences of the United States of America. 110: 549-54. PMID 23267094 DOI: 10.1073/Pnas.1211199110 |
0.417 |
|
| 2011 |
Bolusani S, Young BA, Cole NA, Tibbetts AS, Momb J, Bryant JD, Solmonson A, Appling DR. Mammalian MTHFD2L encodes a mitochondrial methylenetetrahydrofolate dehydrogenase isozyme expressed in adult tissues. The Journal of Biological Chemistry. 286: 5166-74. PMID 21163947 DOI: 10.1074/Jbc.M110.196840 |
0.482 |
|
| 2010 |
Tibbetts AS, Appling DR. Compartmentalization of Mammalian folate-mediated one-carbon metabolism. Annual Review of Nutrition. 30: 57-81. PMID 20645850 DOI: 10.1146/Annurev.Nutr.012809.104810 |
0.492 |
|
| 2010 |
Pike ST, Rajendra R, Artzt K, Appling DR. Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos. The Journal of Biological Chemistry. 285: 4612-20. PMID 19948730 DOI: 10.1074/Jbc.M109.079855 |
0.785 |
|
| 2009 |
Lee C, Tibbetts AS, Kramer G, Appling DR. Yeast AEP3p is an accessory factor in initiation of mitochondrial translation. The Journal of Biological Chemistry. 284: 34116-25. PMID 19843529 DOI: 10.1074/Jbc.M109.055350 |
0.593 |
|
| 2009 |
Prasannan P, Appling DR. Human mitochondrial C1-tetrahydrofolate synthase: submitochondrial localization of the full-length enzyme and characterization of a short isoform. Archives of Biochemistry and Biophysics. 481: 86-93. PMID 18996079 DOI: 10.1016/J.Abb.2008.10.028 |
0.791 |
|
| 2007 |
Suliman HS, Appling DR, Robertus JD. The gene for cobalamin-independent methionine synthase is essential in Candida albicans: a potential antifungal target. Archives of Biochemistry and Biophysics. 467: 218-26. PMID 17935688 DOI: 10.1016/J.Abb.2007.09.003 |
0.468 |
|
| 2007 |
Lee C, Kramer G, Graham DE, Appling DR. Yeast mitochondrial initiator tRNA is methylated at guanosine 37 by the Trm5-encoded tRNA (guanine-N1-)-methyltransferase. The Journal of Biological Chemistry. 282: 27744-53. PMID 17652090 DOI: 10.1074/Jbc.M704572200 |
0.626 |
|
| 2007 |
Lu P, Rangan A, Chan SY, Appling DR, Hoffman DW, Marcotte EM. Global metabolic changes following loss of a feedback loop reveal dynamic steady states of the yeast metabolome. Metabolic Engineering. 9: 8-20. PMID 17049899 DOI: 10.1016/J.Ymben.2006.06.003 |
0.372 |
|
| 2007 |
Tibbetts AS, Prasannan P, Appling DR. 29 Enzymology of mammalian mitochondrial one-carbon metabolism Mitochondrion. 7: 412. DOI: 10.1016/j.mito.2007.08.033 |
0.763 |
|
| 2005 |
Wagner W, Breksa AP, Monzingo AF, Appling DR, Robertus JD. Kinetic and structural analysis of active site mutants of monofunctional NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 44: 13163-71. PMID 16185084 DOI: 10.1021/Bi051038X |
0.431 |
|
| 2005 |
Walkup AS, Appling DR. Enzymatic characterization of human mitochondrial C1-tetrahydrofolate synthase. Archives of Biochemistry and Biophysics. 442: 196-205. PMID 16171773 DOI: 10.1016/J.Abb.2005.08.007 |
0.445 |
|
| 2005 |
Garofalo C, Kramer G, Appling DR. Characterization of the C2 subdomain of yeast mitochondrial initiation factor 2. Archives of Biochemistry and Biophysics. 439: 113-20. PMID 15935987 DOI: 10.1016/J.Abb.2005.05.003 |
0.447 |
|
| 2003 |
Howard KM, Muga SJ, Zhang L, Thigpen AE, Appling DR. Characterization of the rat cytoplasmic C1-tetrahydrofolate synthase gene and analysis of its expression in liver regeneration and fetal development. Gene. 319: 85-97. PMID 14597174 DOI: 10.1016/S0378-1119(03)00796-0 |
0.478 |
|
| 2003 |
Chan SY, Appling DR. Regulation of S-adenosylmethionine levels in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 278: 43051-9. PMID 12937179 DOI: 10.1074/Jbc.M308696200 |
0.422 |
|
| 2003 |
Prasannan P, Pike S, Peng K, Shane B, Appling DR. Human mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary calls. The Journal of Biological Chemistry. 278: 43178-87. PMID 12937168 DOI: 10.1074/Jbc.M304319200 |
0.734 |
|
| 2003 |
Tibbetts AS, Oesterlin L, Chan SY, Kramer G, Hardesty B, Appling DR. Mammalian mitochondrial initiation factor 2 supports yeast mitochondrial translation without formylated initiator tRNA. The Journal of Biological Chemistry. 278: 31774-80. PMID 12799364 DOI: 10.1074/Jbc.M304962200 |
0.515 |
|
| 2003 |
Garofalo C, Trinko R, Kramer G, Appling DR, Hardesty B. Purification and characterization of yeast mitochondrial initiation factor 2. Archives of Biochemistry and Biophysics. 413: 243-52. PMID 12729623 DOI: 10.1016/S0003-9861(03)00119-X |
0.388 |
|
| 2002 |
Woldman Y, Appling DR. A general method for determining the contribution of split pathways in metabolite production in the yeast Saccharomyces cerevisiae. Metabolic Engineering. 4: 170-81. PMID 12009796 DOI: 10.1006/Mben.2001.0221 |
0.378 |
|
| 2002 |
Holmes WB, Appling DR. Cloning and characterization of methenyltetrahydrofolate synthetase from Saccharomyces cerevisiae. The Journal of Biological Chemistry. 277: 20205-13. PMID 11923304 DOI: 10.1074/Jbc.M201242200 |
0.745 |
|
| 2002 |
Roje S, Chan SY, Kaplan F, Raymond RK, Horne DW, Appling DR, Hanson AD. Metabolic engineering in yeast demonstrates that S-adenosylmethionine controls flux through the methylenetetrahydrofolate reductase reaction in vivo. The Journal of Biological Chemistry. 277: 4056-61. PMID 11729203 DOI: 10.1074/Jbc.M110651200 |
0.758 |
|
| 2000 |
Monzingo AF, Breksa A, Ernst S, Appling DR, Robertus JD. The X-ray structure of the NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase from Saccharomyces cerevisiae. Protein Science : a Publication of the Protein Society. 9: 1374-81. PMID 10933503 DOI: 10.1110/Ps.9.7.1374 |
0.395 |
|
| 2000 |
Tibbetts AS, Appling DR. Characterization of two 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase isozymes from Saccharomyces cerevisiae. The Journal of Biological Chemistry. 275: 20920-7. PMID 10877846 DOI: 10.1074/Jbc.M909851199 |
0.479 |
|
| 2000 |
Li Y, Holmes WB, Appling DR, RajBhandary UL. Initiation of protein synthesis in Saccharomyces cerevisiae mitochondria without formylation of the initiator tRNA. Journal of Bacteriology. 182: 2886-92. PMID 10781559 DOI: 10.1128/Jb.182.10.2886-2892.2000 |
0.749 |
|
| 1999 |
Raymond RK, Kastanos EK, Appling DR. Saccharomyces cerevisiae expresses two genes encoding isozymes of methylenetetrahydrofolate reductase. Archives of Biochemistry and Biophysics. 372: 300-8. PMID 10600168 DOI: 10.1006/Abbi.1999.1498 |
0.749 |
|
| 1999 |
Roje S, Wang H, McNeil SD, Raymond RK, Appling DR, Shachar-Hill Y, Bohnert HJ, Hanson AD. Isolation, characterization, and functional expression of cDNAs encoding NADH-dependent methylenetetrahydrofolate reductase from higher plants. The Journal of Biological Chemistry. 274: 36089-96. PMID 10593891 DOI: 10.1074/Jbc.274.51.36089 |
0.751 |
|
| 1997 |
Kastanos EK, Woldman YY, Appling DR. Role of mitochondrial and cytoplasmic serine hydroxymethyltransferase isozymes in de novo purine synthesis in Saccharomyces cerevisiae. Biochemistry. 36: 14956-64. PMID 9398220 DOI: 10.1021/Bi971610N |
0.5 |
|
| 1997 |
Appling DR, Kastanos E, Pasternack LB, Woldman YY. Use of 13C nuclear magnetic resonance to evaluate metabolic flux through folate one-carbon pools in Saccharomyces cerevisiae. Methods in Enzymology. 281: 218-31. PMID 9250986 DOI: 10.1016/S0076-6879(97)81028-2 |
0.423 |
|
| 1997 |
Appling DR, West MG. Monofunctional NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase from Saccharomyces cerevisiae. Methods in Enzymology. 281: 178-88. PMID 9250982 DOI: 10.1016/S0076-6879(97)81024-5 |
0.387 |
|
| 1997 |
Tibbetts AS, Appling DR. Saccharomyces cerevisiae expresses two genes encoding isozymes of 5-aminoimidazole-4-carboxamide ribonucleotide transformylase. Archives of Biochemistry and Biophysics. 340: 195-200. PMID 9143321 DOI: 10.1006/Abbi.1997.9919 |
0.465 |
|
| 1996 |
Monzingo AF, West MG, Schelp E, Appling DR, Robertus JD. Crystallization of the NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase from Saccharomyces cerevisiae. Proteins. 26: 481-2. PMID 8990502 DOI: 10.1002/(Sici)1097-0134(199612)26:4<481::Aid-Prot10>3.0.Co;2-J |
0.3 |
|
| 1996 |
Kirksey TJ, Appling DR. Site-directed mutagenesis of a highly conserved aspartate in the putative 10-formyl-tetrahydrofolate binding site of yeast C1-tetrahydrofolate synthase. Archives of Biochemistry and Biophysics. 333: 251-9. PMID 8806778 DOI: 10.1006/Abbi.1996.0388 |
0.426 |
|
| 1996 |
West MG, Horne DW, Appling DR. Metabolic role of cytoplasmic isozymes of 5,10-methylenetetrahydrofolate dehydrogenase in Saccharomyces cerevisiae. Biochemistry. 35: 3122-32. PMID 8608153 DOI: 10.1021/Bi952713D |
0.468 |
|
| 1996 |
Pasternack LB, Littlepage LE, Laude DA, Appling DR. 13C NMR analysis of the use of alternative donors to the tetrahydrofolate-dependent one-carbon pools in Saccharomyces cerevisiae. Archives of Biochemistry and Biophysics. 326: 158-65. PMID 8579365 DOI: 10.1006/Abbi.1996.0060 |
0.376 |
|
| 1994 |
Pasternack LB, Laude DA, Appling DR. 13C NMR analysis of intercompartmental flow of one-carbon units into choline and purines in Saccharomyces cerevisiae. Biochemistry. 33: 74-82. PMID 8286365 DOI: 10.1021/Bi00167A010 |
0.462 |
|
| 1994 |
Pasternack LB, Laude DA, Appling DR. Whole-cell detection by 13C NMR of metabolic flux through the C1-tetrahydrofolate synthase/serine hydroxymethyltransferase enzyme system and effect of antifolate exposure in Saccharomyces cerevisiae. Biochemistry. 33: 7166-73. PMID 8003483 DOI: 10.1021/Bi00189A020 |
0.459 |
|
| 1993 |
García-Martínez LF, Appling DR. Characterization of the folate-dependent mitochondrial oxidation of carbon 3 of serine. Biochemistry. 32: 4671-6. PMID 8485144 DOI: 10.1021/Bi00068A027 |
0.403 |
|
| 1993 |
West MG, Barlowe CK, Appling DR. Cloning and characterization of the Saccharomyces cerevisiae gene encoding NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase. The Journal of Biological Chemistry. 268: 153-60. PMID 8416923 |
0.364 |
|
| 1992 |
Pasternack LB, Laude DA, Appling DR. 13C NMR detection of folate-mediated serine and glycine synthesis in vivo in Saccharomyces cerevisiae. Biochemistry. 31: 8713-9. PMID 1390656 DOI: 10.1021/Bi00152A005 |
0.509 |
|
| 1991 |
Appling DR. Compartmentation of folate-mediated one-carbon metabolism in eukaryotes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 5: 2645-51. PMID 1916088 DOI: 10.1096/Fasebj.5.12.1916088 |
0.427 |
|
| 1990 |
Barlowe CK, Appling DR. Molecular genetic analysis of Saccharomyces cerevisiae C1-tetrahydrofolate synthase mutants reveals a noncatalytic function of the ADE3 gene product and an additional folate-dependent enzyme. Molecular and Cellular Biology. 10: 5679-87. PMID 2233711 |
0.432 |
|
| 1990 |
Barlowe CK, Appling DR. Isolation and characterization of a novel eukaryotic monofunctional NAD(+)-dependent 5,10-methylenetetrahydrofolate dehydrogenase. Biochemistry. 29: 7089-94. PMID 2223762 |
0.313 |
|
| 1990 |
Thigpen AE, West MG, Appling DR. Rat C1-tetrahydrofolate synthase. cDNA isolation, tissue-specific levels of the mRNA, and expression of the protein in yeast. The Journal of Biological Chemistry. 265: 7907-13. PMID 2186031 |
0.379 |
|
| 1989 |
Barlowe CK, Appling DR. A general method for generation and analysis of defined mutations in enzymes involved in a tetrahydrofolate-interconversion pathway. Biofactors (Oxford, England). 2: 57-63. PMID 2679653 |
0.396 |
|
| 1989 |
Barlowe CK, Williams ME, Rabinowitz JC, Appling DR. Site-directed mutagenesis of yeast C1-tetrahydrofolate synthase: analysis of an overlapping active site in a multifunctional enzyme. Biochemistry. 28: 2099-106. PMID 2541774 DOI: 10.1021/Bi00431A020 |
0.597 |
|
| 1989 |
Cheek WD, Appling DR. Purification, immunoassay, and tissue distribution of rat C1-tetrahydrofolate synthase. Archives of Biochemistry and Biophysics. 270: 504-12. PMID 2468308 DOI: 10.1016/0003-9861(89)90532-8 |
0.464 |
|
| 1988 |
Barlowe CK, Appling DR. In vitro evidence for the involvement of mitochondrial folate metabolism in the supply of cytoplasmic one-carbon units. Biofactors (Oxford, England). 1: 171-6. PMID 2475123 |
0.361 |
|
| 1985 |
Appling DR, Rabinowitz JC. Evidence for overlapping active sites in a multifunctional enzyme: immunochemical and chemical modification studies on C1-tetrahydrofolate synthase from Saccharomyces cerevisiae. Biochemistry. 24: 3540-7. PMID 3899168 DOI: 10.1021/Bi00335A023 |
0.581 |
|
| 1985 |
Appling DR, Rabinowitz JC. Regulation of expression of the ADE3 gene for yeast C1-tetrahydrofolate synthase, a trifunctional enzyme involved in one-carbon metabolism. The Journal of Biological Chemistry. 260: 1248-56. PMID 3881424 |
0.644 |
|
| 1981 |
Appling DR, Chytil F. Evidence of a role for retinoic acid (vitamin A-acid) in the maintenance of testosterone production in male rats. Endocrinology. 108: 2120-4. PMID 7227300 DOI: 10.1210/Endo-108-6-2120 |
0.478 |
|
| 1981 |
Appling DR, Chytil F. Retinoic acid maintains serum testosterone levels in retinol-deficient male rats Federation Proceedings. 40: No. 3472. |
0.469 |
|
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