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Dean R. Appling - Publications

Affiliations: 
Chemistry & Biochemistry University of Texas at Austin, Austin, Texas, U.S.A. 
Area:
Regulation And Organization Of Metabolic Pathways
Website:
http://www.cm.utexas.edu/dean_appling

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Shin M, Vaughn A, Momb J, Appling DR. Deletion of neural tube defect-associated gene Mthfd1l causes reduced cranial mesenchyme density. Birth Defects Research. PMID 31518072 DOI: 10.1002/bdr2.1591  0.44
2018 Bryant JD, Sweeney SR, Sentandreu E, Shin M, Ipas H, Xhemalce B, Momb J, Tiziani S, Appling DR. Deletion of the neural tube defect-associated genedisrupts one-carbon and central energy metabolism in mouse embryos. The Journal of Biological Chemistry. PMID 29483189 DOI: 10.1074/jbc.RA118.002180  0.44
2017 Shin M, Momb J, Appling DR. Human mitochondrial MTHFD2 is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase. Cancer & Metabolism. 5: 11. PMID 29225823 DOI: 10.1186/s40170-017-0173-0  0.44
2015 Hackert ML, Appling DR, Lambowitz AM. Lester Reed: A "complex" man who loved science. Proceedings of the National Academy of Sciences of the United States of America. 112: 6247. PMID 25901319 DOI: 10.1073/pnas.1505119112  0.32
2014 Momb J, Appling DR. Mitochondrial one-carbon metabolism and neural tube defects. Birth Defects Research. Part a, Clinical and Molecular Teratology. 100: 576-83. PMID 24985542 DOI: 10.1002/bdra.23268  0.92
2014 Shin M, Bryant JD, Momb J, Appling DR. Mitochondrial MTHFD2L is a dual redox cofactor-specific methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase expressed in both adult and embryonic tissues. The Journal of Biological Chemistry. 289: 15507-17. PMID 24733394 DOI: 10.1074/jbc.M114.555573  0.92
2013 Momb J, Lewandowski JP, Bryant JD, Fitch R, Surman DR, Vokes SA, Appling DR. Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice. Proceedings of the National Academy of Sciences of the United States of America. 110: 549-54. PMID 23267094 DOI: 10.1073/pnas.1211199110  0.92
2011 Bolusani S, Young BA, Cole NA, Tibbetts AS, Momb J, Bryant JD, Solmonson A, Appling DR. Mammalian MTHFD2L encodes a mitochondrial methylenetetrahydrofolate dehydrogenase isozyme expressed in adult tissues. The Journal of Biological Chemistry. 286: 5166-74. PMID 21163947 DOI: 10.1074/jbc.M110.196840  0.92
2010 Appling DR, Ong DE. Frank Chytil (1924-2010). The Journal of Nutrition. 140: 1711-3. PMID 20724491 DOI: 10.3945/jn.110.129205  0.92
2010 Tibbetts AS, Appling DR. Compartmentalization of Mammalian folate-mediated one-carbon metabolism. Annual Review of Nutrition. 30: 57-81. PMID 20645850 DOI: 10.1146/annurev.nutr.012809.104810  0.92
2010 Pike ST, Rajendra R, Artzt K, Appling DR. Mitochondrial C1-tetrahydrofolate synthase (MTHFD1L) supports the flow of mitochondrial one-carbon units into the methyl cycle in embryos. The Journal of Biological Chemistry. 285: 4612-20. PMID 19948730 DOI: 10.1074/jbc.M109.079855  0.92
2009 Lee C, Tibbetts AS, Kramer G, Appling DR. Yeast AEP3p is an accessory factor in initiation of mitochondrial translation. The Journal of Biological Chemistry. 284: 34116-25. PMID 19843529 DOI: 10.1074/jbc.M109.055350  0.92
2009 Prasannan P, Appling DR. Human mitochondrial C1-tetrahydrofolate synthase: submitochondrial localization of the full-length enzyme and characterization of a short isoform. Archives of Biochemistry and Biophysics. 481: 86-93. PMID 18996079 DOI: 10.1016/j.abb.2008.10.028  0.92
2007 Suliman HS, Appling DR, Robertus JD. The gene for cobalamin-independent methionine synthase is essential in Candida albicans: a potential antifungal target. Archives of Biochemistry and Biophysics. 467: 218-26. PMID 17935688 DOI: 10.1016/j.abb.2007.09.003  0.92
2007 Lee C, Kramer G, Graham DE, Appling DR. Yeast mitochondrial initiator tRNA is methylated at guanosine 37 by the Trm5-encoded tRNA (guanine-N1-)-methyltransferase. The Journal of Biological Chemistry. 282: 27744-53. PMID 17652090 DOI: 10.1074/jbc.M704572200  0.92
2007 Lu P, Rangan A, Chan SY, Appling DR, Hoffman DW, Marcotte EM. Global metabolic changes following loss of a feedback loop reveal dynamic steady states of the yeast metabolome. Metabolic Engineering. 9: 8-20. PMID 17049899 DOI: 10.1016/j.ymben.2006.06.003  0.92
2005 Wagner W, Breksa AP, Monzingo AF, Appling DR, Robertus JD. Kinetic and structural analysis of active site mutants of monofunctional NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase from Saccharomyces cerevisiae. Biochemistry. 44: 13163-71. PMID 16185084 DOI: 10.1021/bi051038x  0.92
2005 Walkup AS, Appling DR. Enzymatic characterization of human mitochondrial C1-tetrahydrofolate synthase. Archives of Biochemistry and Biophysics. 442: 196-205. PMID 16171773 DOI: 10.1016/j.abb.2005.08.007  0.92
2005 Suliman HS, Sawyer GM, Appling DR, Robertus JD. Purification and properties of cobalamin-independent methionine synthase from Candida albicans and Saccharomyces cerevisiae. Archives of Biochemistry and Biophysics. 441: 56-63. PMID 16083849 DOI: 10.1016/j.abb.2005.06.016  0.92
2005 Garofalo C, Kramer G, Appling DR. Characterization of the C2 subdomain of yeast mitochondrial initiation factor 2. Archives of Biochemistry and Biophysics. 439: 113-20. PMID 15935987 DOI: 10.1016/j.abb.2005.05.003  0.92
2003 Howard KM, Muga SJ, Zhang L, Thigpen AE, Appling DR. Characterization of the rat cytoplasmic C1-tetrahydrofolate synthase gene and analysis of its expression in liver regeneration and fetal development. Gene. 319: 85-97. PMID 14597174 DOI: 10.1016/S0378-1119(03)00796-0  0.92
2003 Chan SY, Appling DR. Regulation of S-adenosylmethionine levels in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 278: 43051-9. PMID 12937179 DOI: 10.1074/jbc.M308696200  0.92
2003 Prasannan P, Pike S, Peng K, Shane B, Appling DR. Human mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary calls. The Journal of Biological Chemistry. 278: 43178-87. PMID 12937168 DOI: 10.1074/jbc.M304319200  0.92
2003 Tibbetts AS, Oesterlin L, Chan SY, Kramer G, Hardesty B, Appling DR. Mammalian mitochondrial initiation factor 2 supports yeast mitochondrial translation without formylated initiator tRNA. The Journal of Biological Chemistry. 278: 31774-80. PMID 12799364 DOI: 10.1074/jbc.M304962200  0.92
2003 Garofalo C, Trinko R, Kramer G, Appling DR, Hardesty B. Purification and characterization of yeast mitochondrial initiation factor 2. Archives of Biochemistry and Biophysics. 413: 243-52. PMID 12729623 DOI: 10.1016/S0003-9861(03)00119-X  0.92
2002 Woldman Y, Appling DR. A general method for determining the contribution of split pathways in metabolite production in the yeast Saccharomyces cerevisiae. Metabolic Engineering. 4: 170-81. PMID 12009796 DOI: 10.1006/mben.2001.0221  0.92
2002 Holmes WB, Appling DR. Cloning and characterization of methenyltetrahydrofolate synthetase from Saccharomyces cerevisiae. The Journal of Biological Chemistry. 277: 20205-13. PMID 11923304 DOI: 10.1074/jbc.M201242200  0.92
2002 Roje S, Chan SY, Kaplan F, Raymond RK, Horne DW, Appling DR, Hanson AD. Metabolic engineering in yeast demonstrates that S-adenosylmethionine controls flux through the methylenetetrahydrofolate reductase reaction in vivo. The Journal of Biological Chemistry. 277: 4056-61. PMID 11729203 DOI: 10.1074/jbc.M110651200  0.92
2000 Monzingo AF, Breksa A, Ernst S, Appling DR, Robertus JD. The X-ray structure of the NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase from Saccharomyces cerevisiae. Protein Science : a Publication of the Protein Society. 9: 1374-81. PMID 10933503 DOI: 10.1110/ps.9.7.1374  0.92
2000 Tibbetts AS, Appling DR. Characterization of two 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase isozymes from Saccharomyces cerevisiae. The Journal of Biological Chemistry. 275: 20920-7. PMID 10877846 DOI: 10.1074/jbc.M909851199  0.92
2000 Li Y, Holmes WB, Appling DR, RajBhandary UL. Initiation of protein synthesis in Saccharomyces cerevisiae mitochondria without formylation of the initiator tRNA. Journal of Bacteriology. 182: 2886-92. PMID 10781559 DOI: 10.1128/JB.182.10.2886-2892.2000  0.92
1999 Raymond RK, Kastanos EK, Appling DR. Saccharomyces cerevisiae expresses two genes encoding isozymes of methylenetetrahydrofolate reductase. Archives of Biochemistry and Biophysics. 372: 300-8. PMID 10600168 DOI: 10.1006/abbi.1999.1498  0.92
1999 Roje S, Wang H, McNeil SD, Raymond RK, Appling DR, Shachar-Hill Y, Bohnert HJ, Hanson AD. Isolation, characterization, and functional expression of cDNAs encoding NADH-dependent methylenetetrahydrofolate reductase from higher plants. The Journal of Biological Chemistry. 274: 36089-96. PMID 10593891 DOI: 10.1074/jbc.274.51.36089  0.92
1999 Appling DR. Genetic approaches to the study of protein-protein interactions. Methods (San Diego, Calif.). 19: 338-49. PMID 10527736 DOI: 10.1006/meth.1999.0861  0.92
1997 Kastanos EK, Woldman YY, Appling DR. Role of mitochondrial and cytoplasmic serine hydroxymethyltransferase isozymes in de novo purine synthesis in Saccharomyces cerevisiae. Biochemistry. 36: 14956-64. PMID 9398220 DOI: 10.1021/bi971610n  0.92
1997 Appling DR, Kastanos E, Pasternack LB, Woldman YY. Use of 13C nuclear magnetic resonance to evaluate metabolic flux through folate one-carbon pools in Saccharomyces cerevisiae. Methods in Enzymology. 281: 218-31. PMID 9250986 DOI: 10.1016/S0076-6879(97)81028-2  0.92
1997 Appling DR, West MG. Monofunctional NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase from Saccharomyces cerevisiae. Methods in Enzymology. 281: 178-88. PMID 9250982 DOI: 10.1016/S0076-6879(97)81024-5  0.92
1997 Tibbetts AS, Appling DR. Saccharomyces cerevisiae expresses two genes encoding isozymes of 5-aminoimidazole-4-carboxamide ribonucleotide transformylase. Archives of Biochemistry and Biophysics. 340: 195-200. PMID 9143321 DOI: 10.1006/abbi.1997.9919  0.92
1996 Monzingo AF, West MG, Schelp E, Appling DR, Robertus JD. Crystallization of the NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase from Saccharomyces cerevisiae. Proteins. 26: 481-2. PMID 8990502 DOI: 10.1002/(SICI)1097-0134(199612)26:4<481::AID-PROT10>3.0.CO;2-J  0.92
1996 Kirksey TJ, Appling DR. Site-directed mutagenesis of a highly conserved aspartate in the putative 10-formyl-tetrahydrofolate binding site of yeast C1-tetrahydrofolate synthase. Archives of Biochemistry and Biophysics. 333: 251-9. PMID 8806778 DOI: 10.1006/abbi.1996.0388  0.92
1996 West MG, Horne DW, Appling DR. Metabolic role of cytoplasmic isozymes of 5,10-methylenetetrahydrofolate dehydrogenase in Saccharomyces cerevisiae. Biochemistry. 35: 3122-32. PMID 8608153 DOI: 10.1021/bi952713d  0.92
1996 Pasternack LB, Littlepage LE, Laude DA, Appling DR. 13C NMR analysis of the use of alternative donors to the tetrahydrofolate-dependent one-carbon pools in Saccharomyces cerevisiae. Archives of Biochemistry and Biophysics. 326: 158-65. PMID 8579365 DOI: 10.1006/abbi.1996.0060  0.92
1994 Pasternack LB, Laude DA, Appling DR. 13C NMR analysis of intercompartmental flow of one-carbon units into choline and purines in Saccharomyces cerevisiae. Biochemistry. 33: 74-82. PMID 8286365  0.92
1994 Pasternack LB, Laude DA, Appling DR. Whole-cell detection by 13C NMR of metabolic flux through the C1-tetrahydrofolate synthase/serine hydroxymethyltransferase enzyme system and effect of antifolate exposure in Saccharomyces cerevisiae. Biochemistry. 33: 7166-73. PMID 8003483  0.92
1993 García-Martínez LF, Appling DR. Characterization of the folate-dependent mitochondrial oxidation of carbon 3 of serine. Biochemistry. 32: 4671-6. PMID 8485144  0.92
1993 West MG, Barlowe CK, Appling DR. Cloning and characterization of the Saccharomyces cerevisiae gene encoding NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase. The Journal of Biological Chemistry. 268: 153-60. PMID 8416923  0.92
1992 Pasternack LB, Laude DA, Appling DR. 13C NMR detection of folate-mediated serine and glycine synthesis in vivo in Saccharomyces cerevisiae. Biochemistry. 31: 8713-9. PMID 1390656  0.92
1991 Ayo SH, Radnik RA, Glass WF, Garoni JA, Rampt ER, Appling DR, Kreisberg JI. Increased extracellular matrix synthesis and mRNA in mesangial cells grown in high-glucose medium. The American Journal of Physiology. 260: F185-91. PMID 1996670  0.92
1991 Appling DR. Compartmentation of folate-mediated one-carbon metabolism in eukaryotes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 5: 2645-51. PMID 1916088  0.92
1990 Barlowe CK, Appling DR. Molecular genetic analysis of Saccharomyces cerevisiae C1-tetrahydrofolate synthase mutants reveals a noncatalytic function of the ADE3 gene product and an additional folate-dependent enzyme. Molecular and Cellular Biology. 10: 5679-87. PMID 2233711  0.92
1990 Barlowe CK, Appling DR. Isolation and characterization of a novel eukaryotic monofunctional NAD(+)-dependent 5,10-methylenetetrahydrofolate dehydrogenase. Biochemistry. 29: 7089-94. PMID 2223762  0.92
1990 Thigpen AE, West MG, Appling DR. Rat C1-tetrahydrofolate synthase. cDNA isolation, tissue-specific levels of the mRNA, and expression of the protein in yeast. The Journal of Biological Chemistry. 265: 7907-13. PMID 2186031  0.92
1990 Appling DR, Ayo SH, Kreisberg JI. Immunolocalization of C1-tetrahydrofolate synthase in the rat kidney. Biochemical and Biophysical Research Communications. 168: 625-30. PMID 2110454 DOI: 10.1016/0006-291X(90)92366-8  0.92
1989 Barlowe CK, Appling DR. A general method for generation and analysis of defined mutations in enzymes involved in a tetrahydrofolate-interconversion pathway. Biofactors (Oxford, England). 2: 57-63. PMID 2679653  0.92
1989 Barlowe CK, Williams ME, Rabinowitz JC, Appling DR. Site-directed mutagenesis of yeast C1-tetrahydrofolate synthase: analysis of an overlapping active site in a multifunctional enzyme. Biochemistry. 28: 2099-106. PMID 2541774  0.92
1989 Cheek WD, Appling DR. Purification, immunoassay, and tissue distribution of rat C1-tetrahydrofolate synthase. Archives of Biochemistry and Biophysics. 270: 504-12. PMID 2468308 DOI: 10.1016/0003-9861(89)90532-8  0.92
1988 Barlowe CK, Appling DR. Nitrous oxide exposure reduces hepatic C1-tetrahydrofolate synthase expression in rats. Biochemical and Biophysical Research Communications. 157: 245-9. PMID 3264158 DOI: 10.1016/S0006-291X(88)80039-1  0.92
1988 Barlowe CK, Appling DR. In vitro evidence for the involvement of mitochondrial folate metabolism in the supply of cytoplasmic one-carbon units. Biofactors (Oxford, England). 1: 171-6. PMID 2475123  0.92
1985 Appling DR, Rabinowitz JC. Evidence for overlapping active sites in a multifunctional enzyme: immunochemical and chemical modification studies on C1-tetrahydrofolate synthase from Saccharomyces cerevisiae. Biochemistry. 24: 3540-7. PMID 3899168  0.92
1985 Appling DR, Rabinowitz JC. Regulation of expression of the ADE3 gene for yeast C1-tetrahydrofolate synthase, a trifunctional enzyme involved in one-carbon metabolism. The Journal of Biological Chemistry. 260: 1248-56. PMID 3881424  0.92
1981 Staros JV, Morgan DG, Appling DR. A membrane-impermeant, cleavable cross-linker. Dimers of human erythrocyte band 3 subunits cross-linked at the extracytoplasmic membrane face. The Journal of Biological Chemistry. 256: 5890-3. PMID 7240179  0.92
1981 Appling DR, Chytil F. Evidence of a role for retinoic acid (vitamin A-acid) in the maintenance of testosterone production in male rats. Endocrinology. 108: 2120-4. PMID 7227300 DOI: 10.1210/endo-108-6-2120  0.92
1981 Appling DR, Chytil F. Retinoic acid maintains serum testosterone levels in retinol-deficient male rats Federation Proceedings. 40: No. 3472.  0.92
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