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Richard W. Roberts, Ph.D. - Publications

Affiliations: 
Chemistry, Biological Sciences and Chemical Engineering  University of Southern California, Los Angeles, CA, United States 
Area:
protein design, proteins, RNA, DNA, biophysical chemistry, chemical biology, therapeutics, origin of life chemistry
Website:
http://dornsife.usc.edu/cf/faculty-and-staff/faculty.cfm?pid=1008727
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74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Grindel BJ, Engel BJ, Ong JN, Srinivasamani A, Liang X, Zacharias NM, Bast RC, Curran MA, Takahashi TT, Roberts RW, Millward SW. Directed Evolution of PD-L1-Targeted Affibodies by mRNA Display. Acs Chemical Biology. 17: 1543-1555. PMID 35611948 DOI: 10.1021/acschembio.2c00218  0.772
2021 Kamalinia G, Grindel BJ, Takahashi TT, Millward SW, Roberts RW. Directing evolution of novel ligands by mRNA display. Chemical Society Reviews. PMID 34165126 DOI: 10.1039/d1cs00160d  0.84
2020 Evenson WE, Lin WS, Pang K, Czaja AT, Jalali-Yazdi F, Takahashi TT, Malmstadt N, Roberts RW. Enabling Flow-based Kinetic Off-rate Selections using a Microfluidic Enrichment Device (MFED). Analytical Chemistry. PMID 32633489 DOI: 10.1021/Acs.Analchem.0C01867  0.716
2020 Kamalinia G, Engel BJ, Srinivasamani A, Grindel BJ, Ong JN, Curran MA, Takahashi TT, Millward SW, Roberts RW. mRNA Display Discovery of a Novel Programmed Death Ligand 1 (PD-L1) Binding Peptide (a Peptide Ligand for PD-L1). Acs Chemical Biology. PMID 32352272 DOI: 10.1021/Acschembio.0C00264  0.791
2020 Lin W, Evenson WE, Pang K, Roberts R, Malmstadt N. Preparation of Peptides with High Affinity to Cancer Targets in MRNA Display via Continuous-Flow Microfluidics Biophysical Journal. 118: 152a. DOI: 10.1016/J.Bpj.2019.11.950  0.458
2019 Ludwicki MB, Li J, Stephens EA, Roberts RW, Koide S, Hammond PT, DeLisa MP. Broad-Spectrum Proteome Editing with an Engineered Bacterial Ubiquitin Ligase Mimic. Acs Central Science. 5: 852-866. PMID 31139721 DOI: 10.1021/Acscentsci.9B00127  0.381
2018 Li Y, Junge JA, Arnesano C, Gross GG, Miner JH, Moats R, Roberts RW, Arnold DB, Fraser SE. Discs large 1 controls daughter-cell polarity after cytokinesis in vertebrate morphogenesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 30377270 DOI: 10.1073/Pnas.1713959115  0.568
2018 Nichols AL, Noridomi K, Hughes CR, Jalali-Yazdi F, Eaton JB, Lai LH, Advani G, Lukas RJ, Lester HA, Chen L, Roberts RW. α1-FANGs-Protein Ligands Selective for the α-Bungarotoxin site of the α1-Nicotinic Acetylcholine Receptor. Acs Chemical Biology. PMID 30059207 DOI: 10.1021/Acschembio.8B00513  0.307
2018 Garri C, Howell S, Tiemann K, Tiffany A, Jalali-Yazdi F, Alba MM, Katz JE, Takahashi TT, Landgraf R, Gross ME, Roberts RW, Kani K. Identification, characterization and application of a new peptide against anterior gradient homolog 2 (AGR2). Oncotarget. 9: 27363-27379. PMID 29937991 DOI: 10.18632/Oncotarget.25221  0.819
2017 Pisaneschi F, Kelderhouse LE, Hardy A, Engel BJ, Mukhopadhyay U, Gonzalez-Lepera C, Gray JP, Ornelas A, Takahashi TT, Roberts RW, Fiacco SV, Piwnica-Worms D, Millward SW. Automated, Resin-Based Method to Enhance the Specific Activity of Fluorine-18 Clicked PET Radiotracers. Bioconjugate Chemistry. PMID 28150941 DOI: 10.1021/Acs.Bioconjchem.6B00678  0.789
2016 Cetin M, Evenson WE, Gross GG, Jalali-Yazdi F, Krieger D, Arnold D, Takahashi TT, Roberts RW. RasIns: Genetically Encoded Intrabodies of Activated Ras Proteins. Journal of Molecular Biology. PMID 27865780 DOI: 10.1016/J.Jmb.2016.11.008  0.771
2016 Fiacco SV, Kelderhouse LE, Hardy A, Peleg Y, Hu B, Ornelas A, Yang P, Gammon ST, Howell SM, Wang P, Takahashi TT, Millward SW, Roberts RW. Directed Evolution of Scanning Unnatural-Protease-Resistant (SUPR) Peptides for in Vivo Applications. Chembiochem : a European Journal of Chemical Biology. PMID 27465925 DOI: 10.1002/Cbic.201600253  0.802
2016 Gross GG, Straub C, Perez-Sanchez J, Dempsey WP, Junge JA, Roberts RW, Trinh LA, Fraser SE, De Koninck Y, De Koninck P, Sabatini BL, Arnold DB. An E3-ligase-based method for ablating inhibitory synapses. Nature Methods. PMID 27271196 DOI: 10.1038/Nmeth.3894  0.578
2016 Jalali-Yazdi F, Huong Lai L, Takahashi TT, Roberts RW. High-Throughput Measurement of Binding Kinetics by mRNA Display and Next-Generation Sequencing. Angewandte Chemie (International Ed. in English). PMID 26914638 DOI: 10.1002/Anie.201600077  0.711
2016 Kelderhouse LE, Hardy A, Pisaneschi F, Gray JP, Gammon S, Roberts RW, Takahashi TT, Fiacco S, Millward SW. Abstract 4236: SUPR-PET: Nuclear imaging of Her2-positieve breast cancer with SUPR peptides Cancer Research. 76: 4236-4236. DOI: 10.1158/1538-7445.Am2016-4236  0.804
2015 Jalali-Yazdi F, Takahashi TT, Roberts RW. A General, Label-Free Method for Determining Kd and Ligand Concentration Simultaneously. Analytical Chemistry. PMID 26485531 DOI: 10.1021/Acs.Analchem.5B03069  0.678
2015 Kelderhouse L, Hardy A, Takahashi TT, Ornelas A, Gammon S, Howell S, Yang P, Wang P, Roberts RW, Fiacco S, Millward SW. Abstract 1499: SUPR peptides as novel targeted molecular imaging agents for Her2 Cancer Research. 75: 1499-1499. DOI: 10.1158/1538-7445.Am2015-1499  0.821
2014 Howell SM, Fiacco SV, Takahashi TT, Jalali-Yazdi F, Millward SW, Hu B, Wang P, Roberts RW. Serum stable natural peptides designed by mRNA display. Scientific Reports. 4: 6008. PMID 25234472 DOI: 10.1038/Srep06008  0.798
2014 Jalali-Yazdi F, Corbin JM, Takahashi TT, Roberts RW. Robust, quantitative analysis of proteins using peptide immunoreagents, in vitro translation, and an ultrasensitive acoustic resonant sensor. Analytical Chemistry. 86: 4715-22. PMID 24749546 DOI: 10.1021/Ac500084D  0.751
2013 Gross GG, Junge JA, Mora RJ, Kwon HB, Olson CA, Takahashi TT, Liman ER, Ellis-Davies GC, McGee AW, Sabatini BL, Roberts RW, Arnold DB. Recombinant probes for visualizing endogenous synaptic proteins in living neurons. Neuron. 78: 971-85. PMID 23791193 DOI: 10.1016/J.Neuron.2013.04.017  0.77
2013 Xiao L, Hung KC, Takahashi TT, Joo KI, Lim M, Roberts RW, Wang P. Antibody-mimetic ligand selected by mRNA display targets DC-SIGN for dendritic cell-directed antigen delivery. Acs Chemical Biology. 8: 967-77. PMID 23427768 DOI: 10.1021/Cb300680C  0.742
2012 Olson CA, Nie J, Diep J, Al-Shyoukh I, Takahashi TT, Al-Mawsawi LQ, Bolin JM, Elwell AL, Swanson S, Stewart R, Thomson JA, Soh HT, Roberts RW, Sun R. Single-round, multiplexed antibody mimetic design through mRNA display. Angewandte Chemie (International Ed. in English). 51: 12449-53. PMID 23125174 DOI: 10.1002/Anie.201207005  0.737
2011 Olson CA, Adams JD, Takahashi TT, Qi H, Howell SM, Wu TT, Roberts RW, Sun R, Soh HT. Rapid mRNA-display selection of an IL-6 inhibitor using continuous-flow magnetic separation. Angewandte Chemie (International Ed. in English). 50: 8295-8. PMID 21761516 DOI: 10.1002/Anie.201101149  0.791
2010 Ishikawa FN, Curreli M, Olson CA, Liao HI, Sun R, Roberts RW, Cote RJ, Thompson ME, Zhou C. Importance of controlling nanotube density for highly sensitive and reliable biosensors functional in physiological conditions. Acs Nano. 4: 6914-22. PMID 21028792 DOI: 10.1021/Nn101198U  0.427
2010 Qi X, Xia T, Roberts RW. Acridine-N peptide conjugates display enhanced affinity and specificity for boxB RNA targets. Biochemistry. 49: 5782-9. PMID 20527807 DOI: 10.1021/Bi100634H  0.73
2009 Ja WW, Carvalho GB, Madrigal M, Roberts RW, Benzer S. The Drosophila G protein-coupled receptor, Methuselah, exhibits a promiscuous response to peptides. Protein Science : a Publication of the Protein Society. 18: 2203-8. PMID 19672878 DOI: 10.1002/Pro.221  0.747
2009 Ishikawa FN, Chang HK, Curreli M, Liao HI, Olson CA, Chen PC, Zhang R, Roberts RW, Sun R, Cote RJ, Thompson ME, Zhou C. Label-free, electrical detection of the SARS virus N-protein with nanowire biosensors utilizing antibody mimics as capture probes. Acs Nano. 3: 1219-24. PMID 19422193 DOI: 10.1021/Nn900086C  0.504
2009 Takahashi TT, Roberts RW. In vitro selection of protein and peptide libraries using mRNA display. Methods in Molecular Biology (Clifton, N.J.). 535: 293-314. PMID 19377989 DOI: 10.1007/978-1-59745-557-2_17  0.782
2009 Liao HI, Olson CA, Hwang S, Deng H, Wong E, Baric RS, Roberts RW, Sun R. mRNA display design of fibronectin-based intrabodies that detect and inhibit severe acute respiratory syndrome coronavirus nucleocapsid protein. The Journal of Biological Chemistry. 284: 17512-20. PMID 19364769 DOI: 10.1074/Jbc.M901547200  0.54
2009 Adams JD, Takahashi TT, Howell S, Olsen A, Salazar R, Roberts RW, Soh HT. Rapid generation of peptide reagents via microfluidic screening of mRNA libraries Proceedings of Conference, Microtas 2009 - the 13th International Conference On Miniaturized Systems For Chemistry and Life Sciences. 1853-1855.  0.358
2008 Starck SR, Ow Y, Jiang V, Tokuyama M, Rivera M, Qi X, Roberts RW, Shastri N. A distinct translation initiation mechanism generates cryptic peptides for immune surveillance. Plos One. 3: e3460. PMID 18941630 DOI: 10.1371/Journal.Pone.0003460  0.801
2008 Fiacco SV, Roberts RW. N-Methyl scanning mutagenesis generates protease-resistant G protein ligands with improved affinity and selectivity. Chembiochem : a European Journal of Chemical Biology. 9: 2200-3. PMID 18780385 DOI: 10.1002/Cbic.200800208  0.817
2008 Olson CA, Liao HI, Sun R, Roberts RW. mRNA display selection of a high-affinity, modification-specific phospho-IkappaBalpha-binding fibronectin. Acs Chemical Biology. 3: 480-5. PMID 18590330 DOI: 10.1021/Cb800069C  0.636
2008 Austin RJ, Ja WW, Roberts RW. Evolution of class-specific peptides targeting a hot spot of the Galphas subunit. Journal of Molecular Biology. 377: 1406-18. PMID 18329041 DOI: 10.1016/J.Jmb.2008.01.032  0.782
2007 Millward SW, Fiacco S, Austin RJ, Roberts RW. Design of cyclic peptides that bind protein surfaces with antibody-like affinity. Acs Chemical Biology. 2: 625-34. PMID 17894440 DOI: 10.1021/Cb7001126  0.83
2007 Ja WW, West AP, Delker SL, Bjorkman PJ, Benzer S, Roberts RW. Extension of Drosophila melanogaster life span with a GPCR peptide inhibitor. Nature Chemical Biology. 3: 415-9. PMID 17546039 DOI: 10.1038/Nchembio.2007.2  0.744
2007 Olson CA, Roberts RW. Design, expression, and stability of a diverse protein library based on the human fibronectin type III domain. Protein Science : a Publication of the Protein Society. 16: 476-84. PMID 17322532 DOI: 10.1110/Ps.062498407  0.532
2006 Ja WW, Wiser O, Austin RJ, Jan LY, Roberts RW. Turning G proteins on and off using peptide ligands. Acs Chemical Biology. 1: 570-4. PMID 17168552 DOI: 10.1021/Cb600345K  0.728
2006 Wiser O, Qian X, Ehlers M, Ja WW, Roberts RW, Reuveny E, Jan YN, Jan LY. Modulation of basal and receptor-induced GIRK potassium channel activity and neuronal excitability by the mammalian PINS homolog LGN. Neuron. 50: 561-73. PMID 16701207 DOI: 10.1016/J.Neuron.2006.03.046  0.63
2005 Millward SW, Takahashi TT, Roberts RW. A general route for post-translational cyclization of mRNA display libraries. Journal of the American Chemical Society. 127: 14142-3. PMID 16218582 DOI: 10.1021/Ja054373H  0.823
2005 Xia T, Wan C, Roberts RW, Zewail AH. RNA-protein recognition: single-residue ultrafast dynamical control of structural specificity and function. Proceedings of the National Academy of Sciences of the United States of America. 102: 13013-8. PMID 16129822 DOI: 10.1073/Pnas.0506181102  0.676
2005 Ja WW, Adhikari A, Austin RJ, Sprang SR, Roberts RW. A peptide core motif for binding to heterotrimeric G protein alpha subunits. The Journal of Biological Chemistry. 280: 32057-60. PMID 16051611 DOI: 10.1074/Jbc.C500319200  0.738
2005 Ja WW, Olsen BN, Roberts RW. Epitope mapping using mRNA display and a unidirectional nested deletion library. Protein Engineering, Design & Selection : Peds. 18: 309-19. PMID 15980016 DOI: 10.1093/Protein/Gzi038  0.785
2005 Ja WW, Roberts RW. G-protein-directed ligand discovery with peptide combinatorial libraries. Trends in Biochemical Sciences. 30: 318-24. PMID 15950876 DOI: 10.1016/J.Tibs.2005.04.001  0.697
2005 Smith WB, Starck SR, Roberts RW, Schuman EM. Dopaminergic stimulation of local protein synthesis enhances surface expression of GluR1 and synaptic transmission in hippocampal neurons. Neuron. 45: 765-79. PMID 15748851 DOI: 10.1016/J.Neuron.2005.01.015  0.691
2004 Chen IA, Roberts RW, Szostak JW. The emergence of competition between model protocells. Science (New York, N.Y.). 305: 1474-6. PMID 15353806 DOI: 10.1126/Science.1100757  0.637
2004 Starck SR, Green HM, Alberola-Ila J, Roberts RW. A general approach to detect protein expression in vivo using fluorescent puromycin conjugates. Chemistry & Biology. 11: 999-1008. PMID 15271358 DOI: 10.1016/J.Chembiol.2004.05.011  0.714
2004 Ja WW, Roberts RW. In vitro selection of state-specific peptide modulators of G protein signaling using mRNA display. Biochemistry. 43: 9265-75. PMID 15248784 DOI: 10.1021/Bi0498398  0.758
2004 Ueda CT, Roberts RW. Analysis of a long-range interaction between conserved domains of human telomerase RNA. Rna (New York, N.Y.). 10: 139-47. PMID 14681592 DOI: 10.1261/Rna.5118104  0.753
2003 Austin RJ, Xia T, Ren J, Takahashi TT, Roberts RW. Differential modes of recognition in N peptide-boxB complexes. Biochemistry. 42: 14957-67. PMID 14674772 DOI: 10.1021/Bi0351312  0.824
2003 Frankel A, Millward SW, Roberts RW. Encodamers: unnatural peptide oligomers encoded in RNA. Chemistry & Biology. 10: 1043-50. PMID 14652071 DOI: 10.1016/J.Chembiol.2003.11.004  0.767
2003 Barrick JE, Roberts RW. Achieving specificity in selected and wild-type N peptide-RNA complexes: the importance of discrimination against noncognate RNA targets. Biochemistry. 42: 12998-3007. PMID 14596615 DOI: 10.1021/Bi035163P  0.711
2003 Xia T, Frankel A, Takahashi TT, Ren J, Roberts RW. Context and conformation dictate function of a transcription antitermination switch. Nature Structural Biology. 10: 812-9. PMID 14502268 DOI: 10.1038/Nsb983  0.773
2003 Frankel A, Li S, Starck SR, Roberts RW. Unnatural RNA display libraries. Current Opinion in Structural Biology. 13: 506-12. PMID 12948781 DOI: 10.1016/S0959-440X(03)00110-6  0.833
2003 Starck SR, Qi X, Olsen BN, Roberts RW. The puromycin route to assess stereo- and regiochemical constraints on peptide bond formation in eukaryotic ribosomes. Journal of the American Chemical Society. 125: 8090-1. PMID 12837064 DOI: 10.1021/Ja034817E  0.767
2003 Xia T, Becker HC, Wan C, Frankel A, Roberts RW, Zewail AH. The RNA-protein complex: direct probing of the interfacial recognition dynamics and its correlation with biological functions. Proceedings of the National Academy of Sciences of the United States of America. 100: 8119-23. PMID 12815093 DOI: 10.1073/Pnas.1433099100  0.715
2003 Frankel A, Roberts RW. In vitro selection for sense codon suppression. Rna (New York, N.Y.). 9: 780-6. PMID 12810911 DOI: 10.1261/Rna.5350303  0.339
2003 Li S, Roberts RW. A novel strategy for in vitro selection of peptide-drug conjugates. Chemistry & Biology. 10: 233-9. PMID 12670537 DOI: 10.1016/S1074-5521(03)00047-4  0.705
2003 Takahashi TT, Austin RJ, Roberts RW. mRNA display: ligand discovery, interaction analysis and beyond. Trends in Biochemical Sciences. 28: 159-65. PMID 12633996 DOI: 10.1016/S0968-0004(03)00036-7  0.781
2002 Barrick JE, Roberts RW. Sequence analysis of an artificial family of RNA-binding peptides. Protein Science : a Publication of the Protein Society. 11: 2688-96. PMID 12381850 DOI: 10.1110/Ps.0208902  0.681
2002 Austin RJ, Xia T, Ren J, Takahashi TT, Roberts RW. Designed arginine-rich RNA-binding peptides with picomolar affinity. Journal of the American Chemical Society. 124: 10966-7. PMID 12224929 DOI: 10.1021/Ja026610B  0.777
2002 Baggio R, Burgstaller P, Hale SP, Putney AR, Lane M, Lipovsek D, Wright MC, Roberts RW, Liu R, Szostak JW, Wagner RW. Identification of epitope-like consensus motifs using mRNA display. Journal of Molecular Recognition : Jmr. 15: 126-34. PMID 12203838 DOI: 10.1002/Jmr.567  0.628
2002 Li S, Millward S, Roberts R. In vitro selection of mRNA display libraries containing an unnatural amino acid. Journal of the American Chemical Society. 124: 9972-3. PMID 12188645 DOI: 10.1021/Ja026789Q  0.804
2002 Starck SR, Roberts RW. Puromycin oligonucleotides reveal steric restrictions for ribosome entry and multiple modes of translation inhibition. Rna (New York, N.Y.). 8: 890-903. PMID 12166644 DOI: 10.1017/S1355838202022069  0.759
2001 Barrick JE, Takahashi TT, Ren J, Xia T, Roberts RW. Large libraries reveal diverse solutions to an RNA recognition problem. Proceedings of the National Academy of Sciences of the United States of America. 98: 12374-8. PMID 11675487 DOI: 10.1073/Pnas.221467798  0.763
2001 Barrick JE, Takahashi TT, Balakin A, Roberts RW. Selection of RNA-binding peptides using mRNA-peptide fusions. Methods (San Diego, Calif.). 23: 287-93. PMID 11243841 DOI: 10.1006/Meth.2000.1139  0.731
2000 Liu R, Barrick JE, Szostak JW, Roberts RW. Optimized synthesis of RNA-protein fusions for in vitro protein selection. Methods in Enzymology. 318: 268-93. PMID 10889994 DOI: 10.1016/S0076-6879(00)18058-9  0.681
1999 Roberts RW, Ja WW. In vitro selection of nucleic acids and proteins: What are we learning? Current Opinion in Structural Biology. 9: 521-9. PMID 10449375 DOI: 10.1016/S0959-440X(99)80074-8  0.707
1999 Roberts RW. Totally in vitro protein selection using mRNA-protein fusions and ribosome display. Current Opinion in Chemical Biology. 3: 268-73. PMID 10359713 DOI: 10.1016/S1367-5931(99)80042-8  0.478
1997 Roberts RW, Szostak JW. RNA-peptide fusions for the in vitro selection of peptides and proteins. Proceedings of the National Academy of Sciences of the United States of America. 94: 12297-302. PMID 9356443 DOI: 10.1073/Pnas.94.23.12297  0.69
1996 Roberts RW, Crothers DM. Kinetic discrimination in the folding of intramolecular triple helices. Journal of Molecular Biology. 260: 135-46. PMID 8764396 DOI: 10.1006/Jmbi.1996.0388  0.527
1996 Roberts RW, Crothers DM. Prediction of the stability of DNA triplexes. Proceedings of the National Academy of Sciences of the United States of America. 93: 4320-5. PMID 8633063 DOI: 10.1073/Pnas.93.9.4320  0.49
1992 Roberts RW, Crothers DM. Stability and properties of double and triple helices: dramatic effects of RNA or DNA backbone composition. Science (New York, N.Y.). 258: 1463-6. PMID 1279808 DOI: 10.1126/Science.1279808  0.526
1991 Roberts RW, Crothers DM. Specificity and stringency in DNA triplex formation. Proceedings of the National Academy of Sciences of the United States of America. 88: 9397-401. PMID 1946351 DOI: 10.1073/Pnas.88.21.9397  0.545
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