John Chirgwin - Publications

University of Virginia, Charlottesville, VA 
Biochemistry, Molecular Biology

26/111 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Juárez P, Fournier PGJ, Mohammad KS, McKenna RC, Davis HW, Peng XH, Niewolna M, Mauviel A, Chirgwin JM, Guise TA. Halofuginone inhibits TGF-β/BMP signaling and in combination with zoledronic acid enhances inhibition of breast cancer bone metastasis. Oncotarget. 8: 86447-86462. PMID 29156807 DOI: 10.18632/oncotarget.21200  0.32
2015 Fournier PG, Juárez P, Jiang G, Clines GA, Niewolna M, Kim HS, Walton HW, Peng XH, Liu Y, Mohammad KS, Wells CD, Chirgwin JM, Guise TA. The TGF-β Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone. Cancer Cell. 27: 809-21. PMID 25982816 DOI: 10.1016/J.Ccell.2015.04.009  0.32
2014 Siclari VA, Mohammad KS, Tompkins DR, Davis H, McKenna CR, Peng X, Wessner LL, Niewolna M, Guise TA, Suvannasankha A, Chirgwin JM. Tumor-expressed adrenomedullin accelerates breast cancer bone metastasis. Breast Cancer Research : Bcr. 16: 458. PMID 25439669 DOI: 10.1186/S13058-014-0458-Y  0.32
2012 Juárez P, Mohammad KS, Yin JJ, Fournier PG, McKenna RC, Davis HW, Peng XH, Niewolna M, Javelaud D, Chirgwin JM, Mauviel A, Guise TA. Halofuginone inhibits the establishment and progression of melanoma bone metastases. Cancer Research. 72: 6247-56. PMID 23002206 DOI: 10.1158/0008-5472.CAN-12-1444  0.32
2011 Clines GA, Mohammad KS, Grunda JM, Clines KL, Niewolna M, McKenna CR, McKibbin CR, Yanagisawa M, Suva LJ, Chirgwin JM, Guise TA. Regulation of postnatal trabecular bone formation by the osteoblast endothelin A receptor. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 26: 2523-36. PMID 21698666 DOI: 10.1002/jbmr.450  0.32
2009 Dunn LK, Mohammad KS, Fournier PG, McKenna CR, Davis HW, Niewolna M, Peng XH, Chirgwin JM, Guise TA. Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment. Plos One. 4: e6896. PMID 19727403 DOI: 10.1371/Journal.Pone.0006896  0.32
2009 Mohammad KS, Fournier PG, Guise TA, Chirgwin JM. Agents targeting prostate cancer bone metastasis. Anti-Cancer Agents in Medicinal Chemistry. 9: 1079-88. PMID 19719455 DOI: 10.2174/187152009789735008  0.32
2009 Casimiro S, Guise TA, Chirgwin J. The critical role of the bone microenvironment in cancer metastases. Molecular and Cellular Endocrinology. 310: 71-81. PMID 19616059 DOI: 10.1016/J.Mce.2009.07.004  0.32
2008 Mohammad KS, Chirgwin JM, Guise TA. Assessing new bone formation in neonatal calvarial organ cultures. Methods in Molecular Biology (Clifton, N.J.). 455: 37-50. PMID 18463809 DOI: 10.1007/978-1-59745-104-8_3  0.32
2007 Kingsley LA, Fournier PG, Chirgwin JM, Guise TA. Molecular biology of bone metastasis. Molecular Cancer Therapeutics. 6: 2609-17. PMID 17938257 DOI: 10.1158/1535-7163.MCT-07-0234  0.32
2007 Chirgwin JM, Guise TA. Skeletal metastases: decreasing tumor burden by targeting the bone microenvironment. Journal of Cellular Biochemistry. 102: 1333-42. PMID 17907152 DOI: 10.1002/jcb.21556  0.32
2007 Kingsley LA, Chirgwin JM, Guise TA. Breaking new ground to build bone. Proceedings of the National Academy of Sciences of the United States of America. 104: 10753-4. PMID 17581868 DOI: 10.1073/pnas.0704357104  0.32
2007 Clines GA, Mohammad KS, Bao Y, Stephens OW, Suva LJ, Shaughnessy JD, Fox JW, Chirgwin JM, Guise TA. Dickkopf homolog 1 mediates endothelin-1-stimulated new bone formation. Molecular Endocrinology (Baltimore, Md.). 21: 486-98. PMID 17068196 DOI: 10.1210/me.2006-0346  0.32
2007 Bartholin L, Wessner LL, Chirgwin JM, Guise TA. The human Cyr61 gene is a transcriptional target of transforming growth factor beta in cancer cells. Cancer Letters. 246: 230-6. PMID 16616811 DOI: 10.1016/j.canlet.2006.02.019  0.32
2006 Siclari VA, Guise TA, Chirgwin JM. Molecular interactions between breast cancer cells and the bone microenvironment drive skeletal metastases. Cancer Metastasis Reviews. 25: 621-33. PMID 17165131 DOI: 10.1007/S10555-006-9023-1  0.32
2006 Guise TA, Mohammad KS, Clines G, Stebbins EG, Wong DH, Higgins LS, Vessella R, Corey E, Padalecki S, Suva L, Chirgwin JM. Basic mechanisms responsible for osteolytic and osteoblastic bone metastases. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 6213s-6216s. PMID 17062703 DOI: 10.1158/1078-0432.Ccr-06-1007  0.32
2006 Fournier PG, Chirgwin JM, Guise TA. New insights into the role of T cells in the vicious cycle of bone metastases. Current Opinion in Rheumatology. 18: 396-404. PMID 16763461 DOI: 10.1097/01.bor.0000231909.35043.da  0.32
2006 Chirgwin JM, Guise TA. Does prostate-specific antigen contribute to bone metastases? Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 1395-7. PMID 16533760 DOI: 10.1158/1078-0432.CCR-06-0005  0.32
2006 Zudaire E, Martínez A, Garayoa M, Pío R, Kaur G, Woolhiser MR, Metcalfe DD, Hook WA, Siraganian RP, Guise TA, Chirgwin JM, Cuttitta F. Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis. The American Journal of Pathology. 168: 280-91. PMID 16400030 DOI: 10.2353/ajpath.2006.050291  0.32
2005 Bendre MS, Margulies AG, Walser B, Akel NS, Bhattacharrya S, Skinner RA, Swain F, Ramani V, Mohammad KS, Wessner LL, Martinez A, Guise TA, Chirgwin JM, Gaddy D, Suva LJ. Tumor-derived interleukin-8 stimulates osteolysis independent of the receptor activator of nuclear factor-kappaB ligand pathway. Cancer Research. 65: 11001-9. PMID 16322249 DOI: 10.1158/0008-5472.Can-05-2630  0.32
2005 Guise TA, Kozlow WM, Heras-Herzig A, Padalecki SS, Yin JJ, Chirgwin JM. Molecular mechanisms of breast cancer metastases to bone. Clinical Breast Cancer. 5: S46-53. PMID 15807924  0.32
2003 Guise TA, Chirgwin JM. Transforming growth factor-beta in osteolytic breast cancer bone metastases. Clinical Orthopaedics and Related Research. S32-8. PMID 14600590 DOI: 10.1097/01.blo.0000093055.96273.69  0.32
2003 Guise TA, Chirgwin JM. Role of bisphosphonates in prostate cancer bone metastases. Seminars in Oncology. 30: 717-23. PMID 14571419  0.32
2003 Yin JJ, Mohammad KS, Käkönen SM, Harris S, Wu-Wong JR, Wessale JL, Padley RJ, Garrett IR, Chirgwin JM, Guise TA. A causal role for endothelin-1 in the pathogenesis of osteoblastic bone metastases. Proceedings of the National Academy of Sciences of the United States of America. 100: 10954-9. PMID 12941866 DOI: 10.1073/Pnas.1830978100  0.32
2002 Kakonen SM, Selander KS, Chirgwin JM, Yin JJ, Burns S, Rankin WA, Grubbs BG, Dallas M, Cui Y, Guise TA. Transforming growth factor-beta stimulates parathyroid hormone-related protein and osteolytic metastases via Smad and mitogen-activated protein kinase signaling pathways. The Journal of Biological Chemistry. 277: 24571-8. PMID 11964407 DOI: 10.1074/jbc.M202561200  0.32
1999 Yin JJ, Selander K, Chirgwin JM, Dallas M, Grubbs BG, Wieser R, Massagué J, Mundy GR, Guise TA. TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. The Journal of Clinical Investigation. 103: 197-206. PMID 9916131 DOI: 10.1172/Jci3523  0.32
Low-probability matches
2016 Xu L, Mohammad KS, Wu H, Crean C, Poteat B, Cheng Y, Cardoso AA, Marchal CC, Hanenberg H, Abonour R, Kacena MA, Chirgwin JM, Suvannasankha A, Srour EF. Cell adhesion molecule CD166 drives malignant progression and osteolytic disease in multiple myeloma. Cancer Research. PMID 27634757 DOI: 10.1158/0008-5472.Can-16-0517  0.08
2015 Suvannasankha A, Tompkins DR, Edwards DF, Petyaykina KV, Crean CD, Fournier PG, Parker JM, Sandusky GE, Ichikawa S, Imel EA, Chirgwin JM. FGF23 is elevated in multiple myeloma and increases heparanase expression by tumor cells. Oncotarget. PMID 25944690  0.08
2005 Titus B, Frierson HF, Conaway M, Ching K, Guise T, Chirgwin J, Hampton G, Theodorescu D. Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2. Cancer Research. 65: 7320-7. PMID 16103083 DOI: 10.1158/0008-5472.Can-05-1403  0.08
1999 Trevino RJ, Gliubich F, Berni R, Cianci M, Chirgwin JM, Zanotti G, Horowitz PM. NH2-terminal sequence truncation decreases the stability of bovine rhodanese, minimally perturbs its crystal structure, and enhances interaction with GroEL under native conditions. The Journal of Biological Chemistry. 274: 13938-47. PMID 10318804 DOI: 10.1074/Jbc.274.20.13938  0.08
1998 Trevino RJ, Tsalkova T, Kramer G, Hardesty B, Chirgwin JM, Horowitz PM. Truncations at the NH2 terminus of rhodanese destabilize the enzyme and decrease its heterologous expression. The Journal of Biological Chemistry. 273: 27841-7. PMID 9774394 DOI: 10.1074/Jbc.273.43.27841  0.08
1997 Seale JW, Chirgwin JM, Demeler B, Horowitz PM. Preformed GroES oligomers are not required as functional cochaperonins. Journal of Protein Chemistry. 16: 661-8. PMID 9330224 DOI: 10.1023/A:1026350303043  0.08
1995 Trevino RJ, Hunt J, Horowitz PM, Chirgwin JM. Chinese hamster rhodanese cDNA: activity of the expressed protein is not blocked by a C-terminal extension. Protein Expression and Purification. 6: 693-9. PMID 8535164 DOI: 10.1006/Prep.1995.1091  0.08
1995 Kudlicki W, Chirgwin J, Kramer G, Hardesty B. Folding of an enzyme into an active conformation while bound as peptidyl-tRNA to the ribosome. Biochemistry. 34: 14284-7. PMID 7578030 DOI: 10.1021/Bi00044A003  0.08
1992 Miller DM, Kurzban GP, Mendoza JA, Chirgwin JM, Hardies SC, Horowitz PM. Recombinant bovine rhodanese: purification and comparison with bovine liver rhodanese Biochimica Et Biophysica Acta (Bba)/Protein Structure and Molecular. 1121: 286-292. PMID 1627606 DOI: 10.1016/0167-4838(92)90158-A  0.08
1992 Merrill GA, Miller D, Chirgwin J, Horowitz PM. Immunological evidence for a conformational difference between recombinant bovine rhodanese and rhodanese purified from bovine liver Journal of Protein Chemistry. 11: 193-199. PMID 1382437 DOI: 10.1007/Bf01025225  0.08
1989 Berger SL, Chirgwin JM. Isolation of RNA Methods in Enzymology. 180: 3-13. PMID 2482420 DOI: 10.1016/0076-6879(89)80087-4  0.08
1987 Ionasescu V, Murray JC, Burns TL, Ionasescu R, Ferrell R, Searby C, Chirgwin J. Linkage analysis of Charcot-Marie-Tooth neuropathy (HMSN type I) Journal of the Neurological Sciences. 80: 73-78. PMID 3302118 DOI: 10.1016/0022-510X(87)90222-X  0.08
1987 McGill JR, Chirgwin JM, Moore CM, McCombs JL. Chromosome localization of the human renin gene (REN) by in situ hybridization. Cytogenetics and Cell Genetics. 45: 55-7. PMID 3297510 DOI: 10.1159/000132425  0.08
1987 Dahms NM, Lobel P, Breitmeyer J, Chirgwin JM, Kornfeld S. 46 kd mannose 6-phosphate receptor: cloning, expression, and homology to the 215 kd mannose 6-phosphate receptor. Cell. 50: 181-92. PMID 2954652 DOI: 10.1016/0092-8674(87)90214-5  0.08
1987 Lobel P, Dahms NM, Breitmeyer J, Chirgwin JM, Kornfeld S. Cloning of the bovine 215-kDa cation-independent mannose 6-phosphate receptor. Proceedings of the National Academy of Sciences of the United States of America. 84: 2233-7. PMID 2951738 DOI: 10.1073/Pnas.84.8.2233  0.08
1987 MacDonald RJ, Swift GH, Przybyla AE, Chirgwin JM. Isolation of RNA using guanidinium salts Methods in Enzymology. 152: 219-226. PMID 2443794 DOI: 10.1016/0076-6879(87)52023-7  0.08
1987 Krause JE, Chirgwin JM, Carter MS, Xu ZS, Hershey AD. Three rat preprotachykinin mRNAs encode the neuropeptides substance P and neurokinin A. Proceedings of the National Academy of Sciences of the United States of America. 84: 881-5. PMID 2433692 DOI: 10.1073/pnas.84.3.881  0.08
1986 Wentworth BM, Schaefer IM, Villa-Komaroff L, Chirgwin JM. Characterization of the two nonallelic genes encoding mouse preproinsulin Journal of Molecular Evolution. 23: 305-312. PMID 3104603 DOI: 10.1007/Bf02100639  0.08
1984 Sibanda BL, Blundell T, Hobart PM, Fogliano M, Bindra JS, Dominy BW, Chirgwin JM. Computer graphics modelling of human renin. Specificity, catalytic activity and intron-exon junctions Febs Letters. 174: 102-111. PMID 6432579 DOI: 10.1016/0014-5793(84)81086-8  0.08
1979 Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease Biochemistry. 18: 5294-5299. PMID 518835 DOI: 10.1021/Bi00591A005  0.08
1978 Rutter WJ, Pictet RL, Harding JD, Chirgwin JM, MacDonald RJ, Przybyla AE. An analysis of pancreatic development: role of mesenchymal factor and other extracellular factors The Symposium / the Society For Developmental Biology. Society For Developmental Biology. Symposium. 205-227. PMID 347621  0.08
2020 Miyagawa K, Ohata Y, Delgado-Calle J, Teramachi J, Zhou H, Dempster DW, Subler MA, Windle JJ, Chirgwin J, Roodman GD, Kurihara N. Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo. Jci Insight. PMID 32078587 DOI: 10.1172/Jci.Insight.133113  0.01
2019 Marino S, Petrusca DN, Simpson E, Anderson JL, Xie X, Liu Y, Chirgwin J, Roodman GD. Targeting the p62-ZZ/N-End Rule Pathway in Multiple Myeloma Overcomes Proteasome Inhibitor-Resistance Via Induction of Necroptosis and Enhances the Bone Anabolic Effects of Proteasome Inhibitors Blood. 134: 4391-4391. DOI: 10.1182/Blood-2019-131865  0.01
2018 Zhou D, Bum-Erdene K, Xu D, Liu D, Tompkins D, Sulaiman RS, Corson TW, Chirgwin JM, Meroueh SO. Small molecules inhibit ex vivo tumor growth in bone. Bioorganic & Medicinal Chemistry. PMID 30470597 DOI: 10.1016/J.Bmc.2018.11.025  0.01
2018 Lontos K, Adamik J, Tsagianni A, Galson DL, Chirgwin JM, Suvannasankha A. The Role of Semaphorin 4D in Bone Remodeling and Cancer Metastasis. Frontiers in Endocrinology. 9: 322. PMID 29971044 DOI: 10.3389/Fendo.2018.00322  0.01
2018 Suvannasankha A, Crean C, Ochoa IC, Roodman GD, Chirgwin J. PTHrP May Contribute to Cachexia Accompanying Multiple Myeloma Bone Disease Blood. 132: 4450-4450. DOI: 10.1182/Blood-2018-99-115680  0.01
2016 Delgado-Calle J, Anderson J, Cregor MD, Hiasa M, Chirgwin JM, Carlesso N, Yoneda T, Mohammad KS, Plotkin LI, Roodman GD, Bellido T. Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma. Cancer Research. 76: 1089-100. PMID 26833121 DOI: 10.1158/0008-5472.CAN-15-1703  0.01
2016 Suvannasankha A, Crean CD, Tompkins DR, Delgado-Calle J, Bellido TM, Roodman GD, Chirgwin JM. Regulation of Osteoblast Function in Myeloma Bone Disease By Semaphorin 4D Blood. 128: 4439-4439. DOI: 10.1182/Blood.V128.22.4439.4439  0.01
2016 Ohata Y, Chirgwin JM, Windle JJ, Roodman GD, Kurihara N. Myeloma Cells Induce High Level of TAF12 Expression in Bone Marrow Stromal Cells, Resulting in Increased Osteoclastogenesis and Myeloma Cell Growth in Response to 1,25(OH)2D3 Blood. 128: 4421-4421. DOI: 10.1182/Blood.V128.22.4421.4421  0.01
2014 Suvannasankha A, Chirgwin JM. Role of bone-anabolic agents in the treatment of breast cancer bone metastases. Breast Cancer Research : Bcr. 16: 484. PMID 25757219 DOI: 10.1186/s13058-014-0484-9  0.01
2014 Kurihara N, Kitagawa Y, Inagaki Y, Windle JJ, Chirgwin JM, Roodman GD. TAF12 Enhances the Biological Reponses of Myeloma Cells to Low Concentrations of 1,25-(OH)2dvitamin D3 Blood. 124: 2066-2066. DOI: 10.1182/Blood.V124.21.2066.2066  0.01
2013 Xu L, Machal C, Wu H, Poteat B, Crean CD, Cardoso AA, Chirgwin JM, Hanenberg H, Mohammad KS, Suvannasankha A, Srour EF. Role Of CD166 In Multiple Myeloma Cell Homing To The Bone Marrow Microenvironment and Disease Progression Blood. 122: 3102-3102. DOI: 10.1182/Blood.V122.21.3102.3102  0.01
2013 Suvannasankha A, Tompkins DR, Petyaykina K, Crean CD, Condon KW, David Roodman GD, Chirgwin JM. Neonatal Mouse Bone Supports Growth Of Primary Myeloma Cells Ex Vivo and Assessment Of Responses To Antimyeloma Drugs Blood. 122: 1893-1893. DOI: 10.1182/blood.v122.21.1893.1893  0.01
2012 Chirgwin JM. The stem cell niche as a pharmaceutical target for prevention of skeletal metastases. Anti-Cancer Agents in Medicinal Chemistry. 12: 187-93. PMID 22044002  0.01
2012 Teramachi J, Kurihara N, Chirgwin JM, Roodman GD. The Increased 1,25-(OH)2D3 Sensitivity of Myeloma Cells and Marrow Stromal Cells Enhances RANKL Production and Tumor Cell Growth Blood. 120: 3946-3946. DOI: 10.1182/Blood.V120.21.3946.3946  0.01
2011 Fournier P, Edwards D, White K, Chirgwin* J. Osteocyte-derived FGF23 activates EGR-1 signaling in prostate cancer cells: A new vicious cycle in bone metastases Bone. 48: S48. DOI: 10.1016/j.bone.2010.10.136  0.01
2011 Juarez* P, Mohammad K, Mckenna R, Walton H, Niewolna M, Chirgwin J, Guise T. Halofuginone reduces bone metastases: TGF-β-dependent and independent effects Bone. 48: S19-S20. DOI: 10.1016/j.bone.2010.10.050  0.01
2010 Chirgwin JM, Edwards CM, Pedersen EA, Shiozawa Y, Taichman RS, Park SI, McCauley LK, Matsumoto T, Abe M. Meeting report from the IX international meeting on cancer induced bone disease Ibms Bonekey. 7: 32-46. DOI: 10.1138/20100426  0.01
2008 Sackett DL, Ozbun L, Zudaire E, Wessner L, Chirgwin JM, Cuttitta F, Martínez A. Intracellular proadrenomedullin-derived peptides decorate the microtubules and contribute to cytoskeleton function. Endocrinology. 149: 2888-98. PMID 18325988 DOI: 10.1210/en.2007-1763  0.01
2008 Fournier P, Clines G, Chirgwin J, Guise T. P32. Transforming growth factor-β (TGF-β) promotes prostate cancer bone metastases: Increased expression of pro-osteolytic genes and of PMEPA1, a new TGF-β signalling regulator Cancer Treatment Reviews. 34: 25. DOI: 10.1016/J.Ctrv.2008.03.074  0.01
2008 Kingsley L, Fournier P, Chirgwin J, Guise T. P16. Hypoxia and breast cancer bone metastasis: HIF-1α enhances TGF-β signaling and expression of prometastatic factors CXCR4 and VEGF Cancer Treatment Reviews. 34: 18. DOI: 10.1016/J.Ctrv.2008.03.058  0.01
2006 Vessella RL, Guise TA, Susman ES, Suva LJ, Clines GA, Kominsky SL, Weber KL, Chirgwin JM, McCauley LK, Kozlow W. Meeting report from skeletal complications of malignancy IV Bonekey-Osteovision. 3: 15-42. DOI: 10.1138/20060203  0.01
2005 Titus B, Chirgwin J, Guise T, Hampton G, Theodorescu D. 595: The Metastasis Suppressor Gene RhoGDI2 Reduceslung Metastasis in Human Bladder Cancer Via Downregulation of Endothelin 1 Journal of Urology. 173: 163-163. DOI: 10.1016/S0022-5347(18)34835-3  0.01
2004 Solomons JT, Zimmerly EM, Burns S, Krishnamurthy N, Swan MK, Krings S, Muirhead H, Chirgwin J, Davies C. The crystal structure of mouse phosphoglucose isomerase at 1.6A resolution and its complex with glucose 6-phosphate reveals the catalytic mechanism of sugar ring opening. Journal of Molecular Biology. 342: 847-60. PMID 15342241 DOI: 10.1016/J.Jmb.2004.07.085  0.01
2003 Davies C, Muirhead H, Chirgwin J. The structure of human phosphoglucose isomerase complexed with a transition-state analogue. Acta Crystallographica. Section D, Biological Crystallography. 59: 1111-3. PMID 12777791 DOI: 10.1107/S0907444903007352  0.01
2003 Chirgwin JM, Guise TA. Molecular mechanisms of cancer metastases to bone Current Opinion in Orthopaedics. 14: 317-321. DOI: 10.1097/00001433-200310000-00003  0.01
2001 Read J, Pearce J, Li X, Muirhead H, Chirgwin J, Davies C. The crystal structure of human phosphoglucose isomerase at 1.6 A resolution: implications for catalytic mechanism, cytokine activity and haemolytic anaemia. Journal of Molecular Biology. 309: 447-63. PMID 11371164 DOI: 10.1006/Jmbi.2001.4680  0.01
2001 Shah DM, Banu JM, Chirgwin JM, Tekmal RR. Reproductive tissue renin gene expression in preeclampsia. Hypertension in Pregnancy. 19: 341-51. PMID 11118408 DOI: 10.1081/PRG-100101996  0.01
2001 Sachdev D, Chirgwin JM. Fusions to maltose-binding protein: control of folding and solubility in protein purification. Methods in Enzymology. 326: 312-21. PMID 11036650 DOI: 10.1016/S0076-6879(00)26062-X  0.01
2000 Wang F, Duan R, Chirgwin J, Safe SH. Transcriptional activation of cathepsin D gene expression by growth factors. Journal of Molecular Endocrinology. 24: 193-202. PMID 10750020 DOI: 10.1677/Jme.0.0240193  0.01
2000 Li X, Chirgwin JM. Rabbit phosphoglucose isomerase/neuroleukin/autocrine motility factor: cloning via interspecies identity. Biochimica Et Biophysica Acta. 1476: 363-7. PMID 10669800 DOI: 10.1016/S0167-4838(99)00258-7  0.01
2000 Chirgwin JM, Guise TA. Molecular Mechanisms of Tumor-Bone Interactions in Osteolytic Metastases Critical Reviews™ in Eukaryotic Gene Expression. 10: 20. DOI: 10.1615/CRITREVEUKARGENEEXPR.V10.I2.50  0.01
1999 Sachdev D, Chirgwin JM. Properties of soluble fusions between mammalian aspartic proteinases and bacterial maltose-binding protein. Journal of Protein Chemistry. 18: 127-36. PMID 10071937 DOI: 10.1023/A:1020663903669  0.01
1999 Chirgwin JM. Aspartic Proteinases; Retroviral and Cellular Enzymes. Advances in Experimental Biology and Medicine 436 Edited by M. N. G. James (University of Alberta). Plenum Press:  New York. 1998. $139.50. xvii + 499 pp. ISBN 0-306-45809-8. Journal of the American Chemical Society. 121: 1762-1762. DOI: 10.1021/ja9856811  0.01
1998 Sachdev D, Ohsaki Y, Roodman GD, Chirgwin JM. Epitope mapping of recombinant human procathepsin D. Advances in Experimental Medicine and Biology. 436: 185-9. PMID 9561217 DOI: 10.1007/978-1-4615-5373-1_25  0.01
1998 Chirgwin JM, Schultz S, Sachdev D. Expression of chimeric human aspartic proteinases. Advances in Experimental Medicine and Biology. 436: 139-46. PMID 9561211 DOI: 10.1007/978-1-4615-5373-1_19  0.01
1998 Sachdev D, Chirgwin JM. Order of fusions between bacterial and mammalian proteins can determine solubility in Escherichia coli. Biochemical and Biophysical Research Communications. 244: 933-7. PMID 9535771 DOI: 10.1006/bbrc.1998.8365  0.01
1998 van Dijk S, Dean DD, Liu Y, Zhao Y, Chirgwin JM, Schwartz Z, Boyan BD. Purification, amino acid sequence, and cDNA sequence of a novel calcium-precipitating proteolipid involved in calcification of corynebacterium matruchotii. Calcified Tissue International. 62: 350-8. PMID 9504961 DOI: 10.1007/S002239900443  0.01
1998 Sachdev D, Chirgwin JM. Solubility of proteins isolated from inclusion bodies is enhanced by fusion to maltose-binding protein or thioredoxin. Protein Expression and Purification. 12: 122-32. PMID 9473466 DOI: 10.1006/prep.1997.0826  0.01
1995 Fortenberry SC, Chirgwin JM. The propeptide is nonessential for the expression of human cathepsin D. The Journal of Biological Chemistry. 270: 9778-82. PMID 7730356 DOI: 10.1074/jbc.270.17.9778  0.01
1994 Reddy SV, Scarcez T, Windle JJ, Leach RJ, Hundley JE, Chirgwin JM, Chou JY, Roodman GD. Cloning and characterization of the 5'-flanking region of the mouse tartrate-resistant acid phosphatase gene. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 8: 1263-70. PMID 8256664 DOI: 10.1002/Jbmr.5650081015  0.01
1992 Schorey J, Chirgwin J. Mapping of lysosomal targeting determinants of cathepsin D. Advances in Experimental Medicine and Biology. 306: 339-42. PMID 1812724 DOI: 10.1007/978-1-4684-6012-4_40  0.01
1992 Sachdev D, Schorey J, Chirgwin J. Efficient mutagenesis, expression and purification of procathepsin D. Advances in Experimental Medicine and Biology. 306: 335-8. PMID 1812723 DOI: 10.1007/978-1-4684-6012-4_39  0.01
1990 Naftilan AJ, Williams R, Burt D, Paul M, Pratt RE, Hobart P, Chirgwin J, Dzau VJ. A lack of genetic linkage of renin gene restriction fragment length polymorphisms with human hypertension. Hypertension (Dallas, Tex. : 1979). 14: 614-8. PMID 2573574 DOI: 10.1161/01.HYP.14.6.614  0.01
1990 Chirgwin JM. Molecular biology for nonmolecular biologists. Diabetes Care. 13: 188-97. PMID 2407474 DOI: 10.2337/diacare.13.3.188  0.01
1990 Tandon AK, Clark GM, Chamness GC, Chirgwin JM, McGuire WL. Cathepsin D and prognosis in breast cancer. The New England Journal of Medicine. 322: 297-302. PMID 2296271 DOI: 10.1056/NEJM199002013220504  0.01
1989 Koranyi L, Permutt MA, Chirgwin JM, Giddings SJ. Proinsulin I and II gene expression in inbred mouse strains. Molecular Endocrinology (Baltimore, Md.). 3: 1895-902. PMID 2608062 DOI: 10.1210/mend-3-11-1895  0.01
1987 Rotwein P, Naylor SL, Chirgwin JM. Human insulin-related DNA sequences map to chromosomes 2 and 11. Somatic Cell and Molecular Genetics. 12: 625-31. PMID 3024335 DOI: 10.1007/Bf01671947  0.01
1987 Faust PL, Chirgwin JM, Kornfeld S. Renin, a secretory glycoprotein, acquires phosphomannosyl residues. The Journal of Cell Biology. 105: 1947-55. PMID 2960682 DOI: 10.1083/Jcb.105.5.1947  0.01
1985 Faust PL, Kornfeld S, Chirgwin JM. Cloning and sequence analysis of cDNA for human cathepsin D. Proceedings of the National Academy of Sciences of the United States of America. 82: 4910-4. PMID 3927292 DOI: 10.1073/Pnas.82.15.4910  0.01
1985 Permutt MA, Andreone T, Chirgwin J, Elbein S, Rotwein P, Orland M. The genetics of type I and type II diabetes: analysis by recombinant DNA methodology. Advances in Experimental Medicine and Biology. 189: 89-106. PMID 3898768 DOI: 10.1007/978-1-4757-1850-8_6  0.01
1985 Soares MB, Schon E, Henderson A, Karathanasis SK, Cate R, Zeitlin S, Chirgwin J, Efstratiadis A. RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon. Molecular and Cellular Biology. 5: 2090-103. PMID 2427930 DOI: 10.1128/Mcb.5.8.2090  0.01
1985 Giddings SJ, Chirgwin J, Permutt MA. Evaluation of rat insulin messenger RNA in pancreatic and extrapancreatic tissues. Diabetologia. 28: 343-7. PMID 2412922 DOI: 10.1007/Bf00283141  0.01
1984 Permutt MA, Chirgwin J, Rotwein P, Giddings S. Insulin gene structure and function: a review of studies using recombinant DNA methodology. Diabetes Care. 7: 386-94. PMID 6381010 DOI: 10.2337/Diacare.7.4.386  0.01
1984 Chirgwin JM, Schaefer IM, Rotwein PS, Piccini N, Gross KW, Naylor SL. Human renin gene is on chromosome 1. Somatic Cell and Molecular Genetics. 10: 415-21. PMID 6379904 DOI: 10.1007/Bf01535637  0.01
1984 Hobart PM, Fogliano M, O'Connor BA, Schaefer IM, Chirgwin JM. Human renin gene: structure and sequence analysis. Proceedings of the National Academy of Sciences of the United States of America. 81: 5026-30. PMID 6089171 DOI: 10.1073/pnas.81.16.5026  0.01
1983 Giddings SJ, Rotwein P, Chirgwin JM, Scharp D, Permutt MA. Analysis of insulin gene expression in human pancreas. Diabetes. 32: 777-80. PMID 6347774 DOI: 10.2337/Diab.32.8.777  0.01
1983 Rotwein PS, Chirgwin J, Province M, Knowler WC, Pettitt DJ, Cordell B, Goodman HM, Permutt MA. Polymorphism in the 5' flanking region of the human insulin gene: a genetic marker for non-insulin-dependent diabetes. The New England Journal of Medicine. 308: 65-71. PMID 6292721 DOI: 10.1056/Nejm198301133080202  0.01
1982 Giddings SJ, Chirgwin J, Permutt MA. Effects of glucose on proinsulin messenger RNA in rats in vivo. Diabetes. 31: 624-9. PMID 6761201 DOI: 10.2337/Diab.31.7.624  0.01
1981 Schnackerz KD, Chirgwin JM, Noltmann EA. Synthesis of 1-chloro-2-oxohexanol 6-phosphate, a covalent active-site reagent for phosphoglucose isomerase. Biochemistry. 20: 1756-61. PMID 7225356 DOI: 10.1021/bi00510a008  0.01
1981 Permutt A, Chirgwin J, Giddings S, Kakita K, Rotwein P. Insulin biosynthesis and diabetes mellitus. Clinical Biochemistry. 14: 230-6. PMID 7037227 DOI: 10.1016/S0009-9120(81)90940-1  0.01
1981 Rotwein P, Chyn R, Chirgwin J, Cordell B, Goodman HM, Permut MA. Polymorphism in the 5'-flanking region of the human insulin gene and its possible relation to type 2 diabetes. Science (New York, N.Y.). 213: 1117-20. PMID 6267694 DOI: 10.1126/Science.6267694  0.01
1981 Giddings SJ, Chirgwin J, Permutt MA. The effects of fasting and feeding on preproinsulin messenger RNA in rats. The Journal of Clinical Investigation. 67: 952-60. PMID 6162861 DOI: 10.1172/Jci110145  0.01
1977 Ullrich A, Shine J, Chirgwin J, Pictet R, Tischer E, Rutter WJ, Goodman HM. Rat insulin genes: construction of plasmids containing the coding sequences. Science (New York, N.Y.). 196: 1313-9. PMID 325648 DOI: 10.1126/Science.325648  0.01
1973 Bruch P, Schnackerz KD, Chirgwin JM, Noltmann EA. Binding studies on rabbit-muscle phosphoglucose isomerase. European Journal of Biochemistry. 36: 564-8. PMID 4738401 DOI: 10.1111/j.1432-1033.1973.tb02945.x  0.01
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