Ze'ev Ronai - Publications

Affiliations: 
Molecular Pathology University of California, San Diego, La Jolla, CA 
Area:
Molecular Biology, Biochemistry, Cell Biology

49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Claps G, Cheli Y, Zhang T, Scortegagna M, Lau E, Kim H, Qi J, Li JL, James B, Dzung A, Levesque MP, Dummer R, Hayward NK, Bosenberg M, Brown KM, ... Ronai ZA, et al. A Transcriptionally Inactive ATF2 Variant Drives Melanomagenesis. Cell Reports. PMID 27210757 DOI: 10.1016/j.celrep.2016.04.072  0.56
2016 Merlino G, Herlyn M, Fisher DE, Bastian BC, Flaherty KT, Davies MA, Wargo JA, Curiel-Lewandrowski C, Weber MJ, Leachman SA, Soengas MS, McMahon M, Harbour JW, Swetter SM, Aplin AE, ... ... Ronai ZA, et al. The state of melanoma: challenges and opportunities. Pigment Cell & Melanoma Research. PMID 27087480 DOI: 10.1111/pcmr.12475  0.56
2015 Lau E, Feng Y, Claps G, Fukuda MN, Perlina A, Donn D, Jilaveanu L, Kluger H, Freeze HH, Ronai ZA. The transcription factor ATF2 promotes melanoma metastasis by suppressing protein fucosylation. Science Signaling. 8: ra124. PMID 26645581 DOI: 10.1126/scisignal.aac6479  0.56
2015 Feng Y, Pinkerton AB, Hulea L, Zhang T, Davies MA, Grotegut S, Cheli Y, Yin H, Lau E, Kim H, De SK, Barile E, Pellecchia M, Bosenberg M, Li JL, ... ... Ronai ZA, et al. SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex. Cancer Research. PMID 26603897 DOI: 10.1158/0008-5472.CAN-15-0885  0.56
2015 Ratnikov B, Jeon YJ, Smith JW, Ronai ZA. Right on TARGET: glutamine metabolism in cancer. Oncoscience. 2: 681-3. PMID 26425657 DOI: 10.18632/oncoscience.205  0.56
2015 Kim H, Frederick DT, Levesque MP, Cooper ZA, Feng Y, Krepler C, Brill L, Samuels Y, Hayward NK, Perlina A, Piris A, Zhang T, Halaban R, Herlyn MM, Brown KM, ... ... Ronai ZA, et al. Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation. Cell Reports. 11: 1458-73. PMID 26027934 DOI: 10.1016/j.celrep.2015.04.049  0.56
2015 Jeon YJ, Khelifa S, Ratnikov B, Scott DA, Feng Y, Parisi F, Ruller C, Lau E, Kim H, Brill LM, Jiang T, Rimm DL, Cardiff RD, Mills GB, Smith JW, ... ... Ronai ZA, et al. Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies. Cancer Cell. 27: 354-69. PMID 25759021 DOI: 10.1016/j.ccell.2015.02.006  0.56
2015 Ratnikov B, Aza-Blanc P, Ronai ZA, Smith JW, Osterman AL, Scott DA. Glutamate and asparagine cataplerosis underlie glutamine addiction in melanoma. Oncotarget. 6: 7379-89. PMID 25749035  0.56
2015 Scortegagna M, Lau E, Zhang T, Feng Y, Sereduk C, Yin H, De SK, Meeth K, Platt JT, Langdon CG, Halaban R, Pellecchia M, Davies MA, Brown K, Stern DF, ... ... Ronai ZA, et al. PDK1 and SGK3 Contribute to the Growth of BRAF-Mutant Melanomas and Are Potential Therapeutic Targets. Cancer Research. 75: 1399-412. PMID 25712345 DOI: 10.1158/0008-5472.CAN-14-2785  0.56
2014 Scortegagna M, Kim H, Li JL, Yao H, Brill LM, Han J, Lau E, Bowtell D, Haddad G, Kaufman RJ, Ronai ZA. Fine tuning of the UPR by the ubiquitin ligases Siah1/2. Plos Genetics. 10: e1004348. PMID 24809345 DOI: 10.1371/journal.pgen.1004348  0.56
2014 Maruyama T, Araki T, Kawarazaki Y, Naguro I, Heynen S, Aza-Blanc P, Ronai Z, Matsuzawa A, Ichijo H. Roquin-2 promotes ubiquitin-mediated degradation of ASK1 to regulate stress responses. Science Signaling. 7: ra8. PMID 24448648 DOI: 10.1126/scisignal.2004822  0.56
2013 Grumolato L, Liu G, Haremaki T, Mungamuri SK, Mong P, Akiri G, Lopez-Bergami P, Arita A, Anouar Y, Mlodzik M, Ronai ZA, Brody J, Weinstein DC, Aaronson SA. β-Catenin-independent activation of TCF1/LEF1 in human hematopoietic tumor cells through interaction with ATF2 transcription factors. Plos Genetics. 9: e1003603. PMID 23966864 DOI: 10.1371/journal.pgen.1003603  0.56
2013 Stebbins JL, Santelli E, Feng Y, De SK, Purves A, Motamedchaboki K, Wu B, Ronai ZA, Liddington RC, Pellecchia M. Structure-based design of covalent Siah inhibitors. Chemistry & Biology. 20: 973-82. PMID 23891150 DOI: 10.1016/j.chembiol.2013.06.008  0.56
2013 Gandin V, Gutierrez GJ, Brill LM, Varsano T, Feng Y, Aza-Blanc P, Au Q, McLaughlan S, Ferreira TA, Alain T, Sonenberg N, Topisirovic I, Ronai ZA. Degradation of newly synthesized polypeptides by ribosome-associated RACK1/c-Jun N-terminal kinase/eukaryotic elongation factor 1A2 complex. Molecular and Cellular Biology. 33: 2510-26. PMID 23608534 DOI: 10.1128/MCB.01362-12  0.56
2013 Qi J, Tripathi M, Mishra R, Sahgal N, Fazli L, Fazil L, Ettinger S, Placzek WJ, Claps G, Chung LW, Bowtell D, Gleave M, Bhowmick N, Ronai ZA. The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity. Cancer Cell. 23: 332-46. PMID 23518348 DOI: 10.1016/j.ccr.2013.02.016  0.56
2013 Feng Y, Lau E, Scortegagna M, Ruller C, De SK, Barile E, Krajewski S, Aza-Blanc P, Williams R, Pinkerton AB, Jackson M, Chin L, Pellecchia M, Bosenberg M, Ronai ZA. Inhibition of melanoma development in the Nras((Q61K)) ::Ink4a(-/-) mouse model by the small molecule BI-69A11. Pigment Cell & Melanoma Research. 26: 136-42. PMID 23035722 DOI: 10.1111/pcmr.12033  0.56
2012 Kuang E, Okumura CY, Sheffy-Levin S, Varsano T, Shu VC, Qi J, Niesman IR, Yang HJ, López-Otín C, Yang WY, Reed JC, Broday L, Nizet V, Ronai ZA. Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection. Plos Genetics. 8: e1003007. PMID 23093945 DOI: 10.1371/journal.pgen.1003007  0.56
2012 De Ingeniis J, Ratnikov B, Richardson AD, Scott DA, Aza-Blanc P, De SK, Kazanov M, Pellecchia M, Ronai Z, Osterman AL, Smith JW. Functional specialization in proline biosynthesis of melanoma. Plos One. 7: e45190. PMID 23024808 DOI: 10.1371/journal.pone.0045190  0.56
2012 Lau E, Ronai ZA. ATF2 - at the crossroad of nuclear and cytosolic functions. Journal of Cell Science. 125: 2815-24. PMID 22685333 DOI: 10.1242/jcs.095000  0.56
2012 Yanagiya A, Suyama E, Adachi H, Svitkin YV, Aza-Blanc P, Imataka H, Mikami S, Martineau Y, Ronai ZA, Sonenberg N. Translational homeostasis via the mRNA cap-binding protein, eIF4E. Molecular Cell. 46: 847-58. PMID 22578813 DOI: 10.1016/j.molcel.2012.04.004  0.56
2012 Chen M, Gutierrez GJ, Ronai ZA. The anaphase-promoting complex or cyclosome supports cell survival in response to endoplasmic reticulum stress. Plos One. 7: e35520. PMID 22539978 DOI: 10.1371/journal.pone.0035520  0.56
2012 Filipp FV, Scott DA, Ronai ZA, Osterman AL, Smith JW. Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells Pigment Cell and Melanoma Research. 25: 375-383. PMID 22360810 DOI: 10.1111/j.1755-148X.2012.00989.x  0.56
2012 Wong CS, Sceneay J, House CM, Halse HM, Liu MC, George J, Hunnam TC, Parker BS, Haviv I, Ronai Z, Cullinane C, Bowtell DD, Möller A. Vascular normalization by loss of Siah2 results in increased chemotherapeutic efficacy. Cancer Research. 72: 1694-704. PMID 22354750 DOI: 10.1158/0008-5472.CAN-11-3310  0.56
2012 Lau E, Kluger H, Varsano T, Lee K, Scheffler I, Rimm DL, Ideker T, Ronai ZA. PKCε promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Cell. 148: 543-55. PMID 22304920 DOI: 10.1016/j.cell.2012.01.016  0.56
2011 Kim H, Scimia MC, Wilkinson D, Trelles RD, Wood MR, Bowtell D, Dillin A, Mercola M, Ronai ZA. Fine-tuning of Drp1/Fis1 availability by AKAP121/Siah2 regulates mitochondrial adaptation to hypoxia. Molecular Cell. 44: 532-44. PMID 22099302 DOI: 10.1016/j.molcel.2011.08.045  0.56
2011 Scott DA, Richardson AD, Filipp FV, Knutzen CA, Chiang GG, Ronai ZA, Osterman AL, Smith JW. Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect. The Journal of Biological Chemistry. 286: 42626-34. PMID 21998308 DOI: 10.1074/jbc.M111.282046  0.56
2011 Nagano Y, Fukushima T, Okemoto K, Tanaka K, Bowtell DD, Ronai Z, Reed JC, Matsuzawa S. Siah1/SIP regulates p27(kip1) stability and cell migration under metabolic stress. Cell Cycle (Georgetown, Tex.). 10: 2592-602. PMID 21734459 DOI: 10.4161/cc.10.15.16912  0.56
2011 Feng Y, Barile E, De SK, Stebbins JL, Cortez A, Aza-Blanc P, Villanueva J, Heryln M, Krajewski S, Pellecchia M, Ronai ZA, Chiang GG. Effective inhibition of melanoma by BI-69A11 is mediated by dual targeting of the AKT and NF-κB pathways. Pigment Cell & Melanoma Research. 24: 703-13. PMID 21592316 DOI: 10.1111/j.1755-148X.2011.00867.x  0.56
2011 Chen M, Gutierrez GJ, Ronai ZA. Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control. Proceedings of the National Academy of Sciences of the United States of America. 108: 9119-24. PMID 21571647 DOI: 10.1073/pnas.1100028108  0.56
2011 Lau E, Ronai Z. RAF-isotype switching: from B to C through PDE. Nature Structural & Molecular Biology. 18: 517-8. PMID 21540889 DOI: 10.1038/nsmb.2063  0.56
2010 Li S, Ezhevsky S, Dewing A, Cato MH, Scortegagna M, Bhoumik A, Breitwieser W, Braddock D, Eroshkin A, Qi J, Chen M, Kim JY, Jones S, Jones N, Rickert R, ... Ronai ZA, et al. Radiation Sensitivity and Tumor Susceptibility in ATM Phospho-Mutant ATF2 Mice. Genes & Cancer. 1: 316-330. PMID 20740050 DOI: 10.1177/1947601910370700  0.56
2010 Qi J, Nakayama K, Cardiff RD, Borowsky AD, Kaul K, Williams R, Krajewski S, Mercola D, Carpenter PM, Bowtell D, Ronai ZA. Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors. Cancer Cell. 18: 23-38. PMID 20609350 DOI: 10.1016/j.ccr.2010.05.024  0.56
2010 Gutierrez GJ, Tsuji T, Chen M, Jiang W, Ronai ZA. Interplay between Cdh1 and JNK activity during the cell cycle. Nature Cell Biology. 12: 686-95. PMID 20581839 DOI: 10.1038/ncb2071  0.56
2010 Gutierrez GJ, Tsuji T, Cross JV, Davis RJ, Templeton DJ, Jiang W, Ronai ZA. JNK-mediated phosphorylation of Cdc25C regulates cell cycle entry and G(2)/M DNA damage checkpoint. The Journal of Biological Chemistry. 285: 14217-28. PMID 20220133 DOI: 10.1074/jbc.M110.121848  0.56
2010 Calonge TM, Eshaghi M, Liu J, Ronai Z, O'Connell MJ. Transformation/transcription domain-associated protein (TRRAP)-mediated regulation of Wee1. Genetics. 185: 81-93. PMID 20194963 DOI: 10.1534/genetics.110.114769  0.56
2009 Topisirovic I, Gutierrez GJ, Chen M, Appella E, Borden KL, Ronai ZA. Control of p53 multimerization by Ubc13 is JNK-regulated. Proceedings of the National Academy of Sciences of the United States of America. 106: 12676-81. PMID 19651615 DOI: 10.1073/pnas.0900596106  0.56
2009 Katiyar S, Liu E, Knutzen CA, Lang ES, Lombardo CR, Sankar S, Toth JI, Petroski MD, Ronai Z, Chiang GG. REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A-DDB1 ubiquitin ligase Embo Reports. 10: 866-872. PMID 19557001 DOI: 10.1038/embor.2009.93  0.56
2009 Xiong H, Wang D, Chen L, Choo YS, Ma H, Tang C, Xia K, Jiang W, Ronai Z, Zhuang X, Zhang Z. Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. The Journal of Clinical Investigation. 119: 650-60. PMID 19229105 DOI: 10.1172/JCI37617  0.56
2008 Qi J, Nakayama K, Gaitonde S, Goydos JS, Krajewski S, Eroshkin A, Bar-Sagi D, Bowtell D, Ronai Z. The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways. Proceedings of the National Academy of Sciences of the United States of America. 105: 16713-8. PMID 18946040 DOI: 10.1073/pnas.0804063105  0.56
2008 Bhoumik A, Singha N, O'Connell MJ, Ronai ZA. Regulation of TIP60 by ATF2 modulates ATM activation. The Journal of Biological Chemistry. 283: 17605-14. PMID 18397884 DOI: 10.1074/jbc.M802030200  0.56
2008 Delaunay A, Bromberg KD, Hayashi Y, Mirabella M, Burch D, Kirkwood B, Serra C, Malicdan MC, Mizisin AP, Morosetti R, Broccolini A, Guo LT, Jones SN, Lira SA, Puri PL, ... ... Ronai Z, et al. The ER-bound RING finger protein 5 (RNF5/RMA1) causes degenerative myopathy in transgenic mice and is deregulated in inclusion body myositis. Plos One. 3: e1609. PMID 18270596 DOI: 10.1371/journal.pone.0001609  0.56
2007 Pimienta G, Ficarro SB, Gutierrez GJ, Bhoumik A, Peters EC, Ronai Z, Pascual J. Autophosphorylation properties of inactive and active JNK2. Cell Cycle (Georgetown, Tex.). 6: 1762-71. PMID 17637567  0.56
2007 Mikolajczyk J, Drag M, Békés M, Cao JT, Ronai Z, Salvesen GS. Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs. The Journal of Biological Chemistry. 282: 26217-24. PMID 17591783 DOI: 10.1074/jbc.M702444200  0.56
2007 Fukushima T, Matsuzawa SI, Kress CL, Bruey JM, Krajewska M, Lefebvre S, Zapata JM, Ronai Z, Reed JC. Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses Proceedings of the National Academy of Sciences of the United States of America. 104: 6371-6376. PMID 17404240 DOI: 10.1073/pnas.0700548104  0.56
2007 Nakayama K, Gazdoiu S, Abraham R, Pan ZQ, Ronai Z. Hypoxia-induced assembly of prolyl hydroxylase PHD3 into complexes: implications for its activity and susceptibility for degradation by the E3 ligase Siah2. The Biochemical Journal. 401: 217-26. PMID 16958618 DOI: 10.1042/BJ20061135  0.56
2006 Laine A, Topisirovic I, Zhai D, Reed JC, Borden KLB, Ronai Z. Regulation of p53 localization and activity by Ubc13 Molecular and Cellular Biology. 26: 8901-8913. PMID 17000756 DOI: 10.1128/MCB.01156-06  0.56
2006 Gutierrez GJ, Vögtlin A, Castro A, Ferby I, Salvagiotto G, Ronai Z, Lorca T, Nebreda AR. Meiotic regulation of the CDK activator RINGO/Speedy by ubiquitin-proteasome-mediated processing and degradation. Nature Cell Biology. 8: 1084-94. PMID 16964245 DOI: 10.1038/ncb1472  0.56
2006 Gutierrez GJ, Ronai Z. Ubiquitin and SUMO systems in the regulation of mitotic checkpoints. Trends in Biochemical Sciences. 31: 324-32. PMID 16647857 DOI: 10.1016/j.tibs.2006.04.001  0.56
2006 Fukushima T, Zapata JM, Singha NC, Thomas M, Kress CL, Krajewska M, Krajewski S, Ronai Z, Reed JC, Matsuzawa SI. Critical function for SIP, a ubiquitin E3 ligase component of the β-catenin degradation pathway, for thymocyte development and G1 checkpoint Immunity. 24: 29-39. PMID 16413921 DOI: 10.1016/j.immuni.2005.12.002  0.56
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