Vera Gorbunova - Publications

Affiliations: 
Biology University of Rochester, Rochester, NY 
Area:
Biochemistry, Molecular Biology, Cell Biology, Oncology
Website:
https://www.sas.rochester.edu/bio/people/faculty/gorbunova_vera/

105 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beauséjour C, Ambati J, Ambati K, Simon M, ... ... Gorbunova V, et al. Author Correction: L1 drives IFN in senescent cells and promotes age-associated inflammation. Nature. PMID 31296937 DOI: 10.1038/s41586-019-1350-9  0.72
2019 Chen Y, Zhang H, Xu Z, Tang H, Geng A, Cai B, Su T, Shi J, Jiang C, Tian X, Seluanov A, Huang J, Wan X, Jiang Y, Gorbunova V, et al. A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites. Nucleic Acids Research. PMID 31291457 DOI: 10.1093/nar/gkz592  0.72
2019 Katagi H, Louis N, Unruh D, Sasaki T, He X, Zhang A, Ma Q, Piunti A, Shimazu Y, Lamano JB, Carcaboso AM, Tian X, Seluanov A, Gorbunova V, Laurie KL, et al. Radiosensitization by Histone H3 Demethylase Inhibition in Diffuse Intrinsic Pontine Glioma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31227500 DOI: 10.1158/1078-0432.CCR-18-3890  0.72
2019 Rezazadeh S, Yang D, Tombline G, Simon M, Regan SP, Seluanov A, Gorbunova V. SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170. Nucleic Acids Research. PMID 31216030 DOI: 10.1093/nar/gkz528  0.72
2019 Bozek K, Khrameeva EE, Reznick J, Omerbašić D, Bennett NC, Lewin GR, Azpurua J, Gorbunova V, Seluanov A, Regnard P, Wanert F, Marchal J, Pifferi F, Aujard F, Liu Z, et al. Publisher Correction: Lipidome determinants of maximal lifespan in mammals. Scientific Reports. 9: 6972. PMID 31043659 DOI: 10.1038/s41598-019-43122-9  0.72
2019 Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, ... ... Gorbunova V, et al. SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species. Cell. 177: 622-638.e22. PMID 31002797 DOI: 10.1016/j.cell.2019.03.043  0.72
2019 Simon M, Van Meter M, Ablaeva J, Ke Z, Gonzalez RS, Taguchi T, De Cecco M, Leonova KI, Kogan V, Helfand SL, Neretti N, Roichman A, Cohen HY, Meer MV, Gladyshev VN, ... ... Gorbunova V, et al. LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation. Cell Metabolism. PMID 30853213 DOI: 10.1016/j.cmet.2019.02.014  0.72
2019 Núñez FJ, Mendez FM, Kadiyala P, Alghamri MS, Savelieff MG, Garcia-Fabiani MB, Haase S, Koschmann C, Calinescu AA, Kamran N, Saxena M, Patel R, Carney S, Guo MZ, Edwards M, ... ... Gorbunova V, et al. IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response. Science Translational Medicine. 11. PMID 30760578 DOI: 10.1126/scitranslmed.aaq1427  0.56
2019 De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beauséjour C, Ambati J, Ambati K, Simon M, ... ... Gorbunova V, et al. L1 drives IFN in senescent cells and promotes age-associated inflammation. Nature. 566: 73-78. PMID 30728521 DOI: 10.1038/s41586-018-0784-9  0.72
2018 Bourque G, Burns KH, Gehring M, Gorbunova V, Seluanov A, Hammell M, Imbeault M, Izsvák Z, Levin HL, Macfarlan TS, Mager DL, Feschotte C. Ten things you should know about transposable elements. Genome Biology. 19: 199. PMID 30454069 DOI: 10.1186/s13059-018-1577-z  0.72
2018 Evdokimov A, Kutuzov M, Petruseva I, Lukjanchikova N, Kashina E, Kolova E, Zemerova T, Romanenko S, Perelman P, Prokopov D, Seluanov A, Gorbunova V, Graphodatsky A, Trifonov V, Khodyreva S, et al. Naked mole rat cells display more efficient excision repair than mouse cells. Aging. PMID 29930219 DOI: 10.18632/aging.101482  0.72
2018 Seluanov A, Gladyshev VN, Vijg J, Gorbunova V. Mechanisms of cancer resistance in long-lived mammals. Nature Reviews. Cancer. PMID 29622806 DOI: 10.1038/s41568-018-0004-9  0.72
2018 Ke Z, Seluanov A, Gorbunova V. Accurate translation is important for longevity. Aging. PMID 29531183 DOI: 10.18632/aging.101398  0.72
2018 Ghosh S, Wong SK, Jiang Z, Liu B, Wang Y, Hao Q, Gorbunova V, Liu X, Zhou Z. Haploinsufficiency ofdramatically extends the lifespan of Sirt6-deficient mice. Elife. 7. PMID 29474172 DOI: 10.7554/eLife.32127  0.72
2018 Zhao Y, Tyshkovskiy A, Muñoz-Espín D, Tian X, Serrano M, de Magalhaes JP, Nevo E, Gladyshev VN, Seluanov A, Gorbunova V. Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence. Proceedings of the National Academy of Sciences of the United States of America. PMID 29432174 DOI: 10.1073/pnas.1721160115  0.72
2018 Tian X, Doerig K, Park R, Can Ran Qin A, Hwang C, Neary A, Gilbert M, Seluanov A, Gorbunova V. Evolution of telomere maintenance and tumour suppressor mechanisms across mammals. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 373. PMID 29335367 DOI: 10.1098/rstb.2016.0443  0.72
2018 Swovick K, Welle KA, Hryhorenko J, Seluanov A, Gorbunova V, Ghaemmaghami S. Cross-species comparison of proteome turnover kinetics. Molecular & Cellular Proteomics : McP. PMID 29321186 DOI: 10.1074/mcp.RA117.000574  0.72
2017 Tan L, Ke Z, Tombline G, Macoretta N, Hayes K, Tian X, Lv R, Ablaeva J, Gilbert M, Bhanu NV, Yuan ZF, Garcia BA, Shi YG, Shi Y, Seluanov A, ... Gorbunova V, et al. Naked Mole Rat Cells Have a Stable Epigenome that Resists iPSC Reprogramming. Stem Cell Reports. PMID 29107597 DOI: 10.1016/j.stemcr.2017.10.001  0.72
2017 Tian X, Seluanov A, Gorbunova V. Molecular Mechanisms Determining Lifespan in Short- and Long-Lived Species. Trends in Endocrinology and Metabolism: Tem. PMID 28888702 DOI: 10.1016/j.tem.2017.07.004  0.72
2017 Ke Z, Mallik P, Johnson AB, Luna F, Nevo E, Zhang ZD, Gladyshev VN, Seluanov A, Gorbunova V. Translation fidelity coevolves with longevity. Aging Cell. PMID 28707419 DOI: 10.1111/acel.12628  0.72
2017 Kristeleit R, Davidenko I, Shirinkin V, El-Khouly F, Bondarenko I, Goodheart MJ, Gorbunova V, Penning CA, Shi JG, Liu X, Newton RC, Zhao Y, Maleski J, Leopold L, Schilder RJ. A randomised, open-label, phase 2 study of the IDO1 inhibitor epacadostat (INCB024360) versus tamoxifen as therapy for biochemically recurrent (CA-125 relapse)-only epithelial ovarian cancer, primary peritoneal carcinoma, or fallopian tube cancer. Gynecologic Oncology. PMID 28698009 DOI: 10.1016/j.ygyno.2017.07.005  0.72
2017 Tian X, Seluanov A, Gorbunova V. Beyond Making Ends Meet: DNA-PK, Metabolism, and Aging. Cell Metabolism. 25: 991-992. PMID 28467943 DOI: 10.1016/j.cmet.2017.04.022  0.72
2017 Valenzano DR, Aboobaker A, Seluanov A, Gorbunova V. Non-canonical aging model systems and why we need them. The Embo Journal. PMID 28320740 DOI: 10.15252/embj.201796837  0.72
2017 Moskalev A, Anisimov V, Aliper A, Artemov A, Asadullah K, Belsky D, Baranova A, de Grey A, Dixit VD, Debonneuil E, Dobrovolskaya E, Fedichev P, Fedintsev A, Fraifeld V, Franceschi C, ... ... Gorbunova V, et al. A review of the biomedical innovations for healthy longevity. Aging. PMID 28132958 DOI: 10.18632/aging.101163  0.72
2017 Bozek K, Khrameeva EE, Reznick J, Omerbašić D, Bennett NC, Lewin GR, Azpurua J, Gorbunova V, Seluanov A, Regnard P, Wanert F, Marchal J, Pifferi F, Aujard F, Liu Z, et al. Lipidome determinants of maximal lifespan in mammals. Scientific Reports. 7: 5. PMID 28127055 DOI: 10.1038/s41598-017-00037-7  0.72
2016 Ma S, Upneja A, Galecki A, Tsai YM, Burant CF, Raskind S, Zhang Q, Zhang ZD, Seluanov A, Gorbunova V, Clish CB, Miller RA, Gladyshev VN. Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity. Elife. 5. PMID 27874830 DOI: 10.7554/eLife.19130  0.72
2016 Ramalingam SS, Blais N, Mazieres J, Reck M, Jones CM, Juhász E, Urban L, Orlov S, Barlési F, Kio E, Keiholz U, Qin Q, Qian J, Nickner C, Dziubinski J, ... ... Gorbunova V, et al. Randomized, Placebo-Controlled, Phase 2 Study of Veliparib in Combination with Carboplatin and Paclitaxel for Advanced/Metastatic Non-Small Cell Lung Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27803064 DOI: 10.1158/1078-0432.CCR-15-3069  0.32
2016 Van Meter M, Simon M, Tombline G, May A, Morello TD, Hubbard BP, Bredbenner K, Park R, Sinclair DA, Bohr VA, Gorbunova V, Seluanov A. JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks. Cell Reports. PMID 27568560 DOI: 10.1016/j.celrep.2016.08.006  0.72
2016 Dokukin M, Ablaeva Y, Kalaparthi V, Seluanov A, Gorbunova V, Sokolov I. Pericellular Brush and Mechanics of Guinea Pig Fibroblast Cells Studied with AFM. Biophysical Journal. 111: 236-246. PMID 27410750 DOI: 10.1016/j.bpj.2016.06.005  0.72
2016 Hewitt G, Carroll B, Sarallah R, Correia-Melo C, Ogrodnik M, Nelson G, Otten EG, Manni D, Antrobus R, Morgan BA, von Zglinicki T, Jurk D, Seluanov A, Gorbunova V, Johansen T, et al. SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair. Autophagy. 0. PMID 27391408 DOI: 10.1080/15548627.2016.1210368  0.72
2016 Gorbunova V, Rezazadeh S, Seluanov A. Dangerous Entrapment for NRF2. Cell. 165: 1312-3. PMID 27259142 DOI: 10.1016/j.cell.2016.05.061  0.48
2016 Patrick A, Seluanov M, Hwang C, Tam J, Khan T, Morgenstern A, Wiener L, Vazquez JM, Zafar H, Wen R, Muratkalyeva M, Doerig K, Zagorulya M, Cole L, Catalano S, ... ... Gorbunova V, et al. Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan. Aging. PMID 27163160  0.72
2016 Gorbunova V, Seluanov A. DNA double strand break repair, aging and the chromatin connection. Mutation Research. 788: 2-6. PMID 26923716 DOI: 10.1016/j.mrfmmm.2016.02.004  0.72
2015 MacRae SL, Croken MM, Calder RB, Aliper A, Milholland B, White RR, Zhavoronkov A, Gladyshev VN, Seluanov A, Gorbunova V, Zhang ZD, Vijg J. DNA repair in species with extreme lifespan differences. Aging. PMID 26729707  0.72
2015 Ma S, Lee SG, Kim EB, Park TJ, Seluanov A, Gorbunova V, Buffenstein R, Seravalli J, Gladyshev VN. Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity. Cell Reports. PMID 26549444 DOI: 10.1016/j.celrep.2015.10.014  0.72
2015 Fang X, Nevo E, Han L, Levanon EY, Zhao J, Avivi A, Larkin D, Jiang X, Feranchuk S, Zhu Y, Fishman A, Feng Y, Sher N, Xiong Z, Hankeln T, ... ... Gorbunova V, et al. Corrigendum: Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax. Nature Communications. 6: 8051. PMID 26264976 DOI: 10.1038/ncomms9051  0.72
2015 MacRae SL, Zhang Q, Lemetre C, Seim I, Calder RB, Hoeijmakers J, Suh Y, Gladyshev VN, Seluanov A, Gorbunova V, Vijg J, Zhang ZD. Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human. Aging Cell. 14: 288-91. PMID 25645816 DOI: 10.1111/acel.12314  0.72
2015 Xu Z, Zhang L, Zhang W, Meng D, Zhang H, Jiang Y, Xu X, Van Meter M, Seluanov A, Gorbunova V, Mao Z. SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. Cell Cycle (Georgetown, Tex.). 14: 269-76. PMID 25607651 DOI: 10.4161/15384101.2014.980641  0.72
2015 Yang JC, Wu YL, Schuler M, Sebastian M, Popat S, Yamamoto N, Zhou C, Hu CP, O'Byrne K, Feng J, Lu S, Huang Y, Geater SL, Lee KY, Tsai CM, ... Gorbunova V, et al. Afatinib versus cisplatin-based chemotherapy for EGFR mutation-positive lung adenocarcinoma (LUX-Lung 3 and LUX-Lung 6): analysis of overall survival data from two randomised, phase 3 trials. The Lancet. Oncology. 16: 141-51. PMID 25589191 DOI: 10.1016/S1470-2045(14)71173-8  0.48
2015 Ramalingam SS, Shtivelband M, Soo RA, Barrios CH, Makhson A, Segalla JG, Pittman KB, Kolman P, Pereira JR, Srkalovic G, Belani CP, Axelrod R, Owonikoko TK, Qin Q, Qian J, ... ... Gorbunova VA, et al. Randomized phase II study of carboplatin and paclitaxel with either linifanib or placebo for advanced nonsquamous non-small-cell lung cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 33: 433-41. PMID 25559798 DOI: 10.1200/JCO.2014.55.7173  0.48
2015 Tian X, Azpurua J, Ke Z, Augereau A, Zhang ZD, Vijg J, Gladyshev VN, Gorbunova V, Seluanov A. INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform. Proceedings of the National Academy of Sciences of the United States of America. 112: 1053-8. PMID 25550505 DOI: 10.1073/pnas.1418203112  0.72
2015 Cainap C, Qin S, Huang WT, Chung IJ, Pan H, Cheng Y, Kudo M, Kang YK, Chen PJ, Toh HC, Gorbunova V, Eskens FA, Qian J, McKee MD, Ricker JL, et al. Linifanib versus Sorafenib in patients with advanced hepatocellular carcinoma: results of a randomized phase III trial. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 33: 172-9. PMID 25488963 DOI: 10.1200/JCO.2013.54.3298  0.48
2015 Mackey JR, Ramos-Vazquez M, Lipatov O, McCarthy N, Krasnozhon D, Semiglazov V, Manikhas A, Gelmon KA, Konecny GE, Webster M, Hegg R, Verma S, Gorbunova V, Abi Gerges D, Thireau F, et al. Primary results of ROSE/TRIO-12, a randomized placebo-controlled phase III trial evaluating the addition of ramucirumab to first-line docetaxel chemotherapy in metastatic breast cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 33: 141-8. PMID 25185099 DOI: 10.1200/JCO.2014.57.1513  0.48
2014 Gorbunova V, Boeke JD, Helfand SL, Sedivy JM. Human Genomics. Sleeping dogs of the genome. Science (New York, N.Y.). 346: 1187-8. PMID 25477445 DOI: 10.1126/science.aaa3177  0.48
2014 Van Meter M, Kashyap M, Rezazadeh S, Geneva AJ, Morello TD, Seluanov A, Gorbunova V. SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age. Nature Communications. 5: 5011. PMID 25247314 DOI: 10.1038/ncomms6011  0.72
2014 Keane M, Craig T, Alföldi J, Berlin AM, Johnson J, Seluanov A, Gorbunova V, Di Palma F, Lindblad-Toh K, Church GM, de Magalhães JP. The Naked Mole Rat Genome Resource: facilitating analyses of cancer and longevity-related adaptations. Bioinformatics (Oxford, England). 30: 3558-60. PMID 25172923 DOI: 10.1093/bioinformatics/btu579  0.72
2014 de Azambuja E, Holmes AP, Piccart-Gebhart M, Holmes E, Di Cosimo S, Swaby RF, Untch M, Jackisch C, Lang I, Smith I, Boyle F, Xu B, Barrios CH, Perez EA, Azim HA, ... ... Gorbunova V, et al. Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): survival outcomes of a randomised, open-label, multicentre, phase 3 trial and their association with pathological complete response. The Lancet. Oncology. 15: 1137-46. PMID 25130998 DOI: 10.1016/S1470-2045(14)70320-1  0.48
2014 O'Neil BH, Cainap C, Van Cutsem E, Gorbunova V, Karapetis CS, Berlin J, Goldberg RM, Qin Q, Qian J, Ricker JL, Fischer J, McKee MD, Carlson DM, Kim TW. Randomized phase II open-label study of mFOLFOX6 in combination with linifanib or bevacizumab for metastatic colorectal cancer. Clinical Colorectal Cancer. 13: 156-163.e2. PMID 25066269 DOI: 10.1016/j.clcc.2014.04.001  0.48
2014 Vaidya A, Mao Z, Tian X, Spencer B, Seluanov A, Gorbunova V. Knock-in reporter mice demonstrate that DNA repair by non-homologous end joining declines with age. Plos Genetics. 10: e1004511. PMID 25033455 DOI: 10.1371/journal.pgen.1004511  0.48
2014 Van Meter M, Gorbunova V, Seluanov A. SIRT6: a promising target for cancer prevention and therapy. Advances in Experimental Medicine and Biology. 818: 181-96. PMID 25001537 DOI: 10.1007/978-1-4471-6458-6_9  0.72
2014 Gorbunova V, Seluanov A, Zhang Z, Gladyshev VN, Vijg J. Comparative genetics of longevity and cancer: insights from long-lived rodents. Nature Reviews. Genetics. 15: 531-40. PMID 24981598 DOI: 10.1038/nrg3728  0.48
2014 Garon EB, Ciuleanu TE, Arrieta O, Prabhash K, Syrigos KN, Goksel T, Park K, Gorbunova V, Kowalyszyn RD, Pikiel J, Czyzewicz G, Orlov SV, Lewanski CR, Thomas M, Bidoli P, et al. Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial. Lancet (London, England). 384: 665-73. PMID 24933332 DOI: 10.1016/S0140-6736(14)60845-X  0.48
2014 Fang X, Nevo E, Han L, Levanon EY, Zhao J, Avivi A, Larkin D, Jiang X, Feranchuk S, Zhu Y, Fishman A, Feng Y, Sher N, Xiong Z, Hankeln T, ... ... Gorbunova V, et al. Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax. Nature Communications. 5: 3966. PMID 24892994 DOI: 10.1038/ncomms4966  0.48
2014 Hine CM, Li H, Xie L, Mao Z, Seluanov A, Gorbunova V. Regulation of Rad51 promoter. Cell Cycle (Georgetown, Tex.). 13: 2038-45. PMID 24781030 DOI: 10.4161/cc.29016  0.72
2014 Cao Y, Xu Y, Zhang L, Li Z, Jiang Y, Tian X, Seluanov A, Gorbunova V, Mao Z. Utilization of Rad51C promoter for transcriptional targeting of cancer cells. Oncotarget. 5: 1805-11. PMID 24742710 DOI: 10.18632/oncotarget.1792  0.72
2014 Ke Z, Vaidya A, Ascher J, Seluanov A, Gorbunova V. Novel husbandry techniques support survival of naked mole rat (Heterocephalus glaber) pups. Journal of the American Association For Laboratory Animal Science : Jaalas. 53: 89-91. PMID 24411785  0.48
2014 Larkin J, Fishman M, Wood L, Negrier S, Olivier K, Pyle L, Gorbunova V, Jonasch E, Andrews L, Staehler M. Axitinib for the treatment of metastatic renal cell carcinoma: recommendations for therapy management to optimize outcomes. American Journal of Clinical Oncology. 37: 397-403. PMID 23357974 DOI: 10.1097/COC.0b013e31827b45f9  0.48
2013 Azpurua J, Ke Z, Chen IX, Zhang Q, Ermolenko DN, Zhang ZD, Gorbunova V, Seluanov A. Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage. Proceedings of the National Academy of Sciences of the United States of America. 110: 17350-5. PMID 24082110 DOI: 10.1073/pnas.1313473110  0.72
2013 Rittmeyer A, Gorbunova V, Vikström A, Scherpereel A, Kim JH, Ahn MJ, Chella A, Chouaid C, Campbell AK, Barlesi F. Health-related quality of life in patients with advanced nonsquamous non-small-cell lung cancer receiving bevacizumab or bevacizumab-plus-pemetrexed maintenance therapy in AVAPERL (MO22089). Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 8: 1409-16. PMID 24077452 DOI: 10.1097/JTO.0b013e3182a46bcf  0.48
2013 Yang JN, Seluanov A, Gorbunova V. Mitochondrial inverted repeats strongly correlate with lifespan: mtDNA inversions and aging. Plos One. 8: e73318. PMID 24069185 DOI: 10.1371/journal.pone.0073318  0.48
2013 Barlesi F, Scherpereel A, Rittmeyer A, Pazzola A, Ferrer Tur N, Kim JH, Ahn MJ, Aerts JG, Gorbunova V, Vikström A, Wong EK, Perez-Moreno P, Mitchell L, Groen HJ. Randomized phase III trial of maintenance bevacizumab with or without pemetrexed after first-line induction with bevacizumab, cisplatin, and pemetrexed in advanced nonsquamous non-small-cell lung cancer: AVAPERL (MO22089). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: 3004-11. PMID 23835708 DOI: 10.1200/JCO.2012.42.3749  0.48
2013 Tilgner K, Neganova I, Singhapol C, Saretzki G, Al-Aama JY, Evans J, Gorbunova V, Gennery A, Przyborski S, Stojkovic M, Armstrong L, Jeggo P, Lako M. Brief report: A human induced pluripotent stem cell model of cernunnos deficiency reveals an important role for XLF in the survival of the primitive hematopoietic progenitors Stem Cells. 31: 2015-2023. PMID 23818183 DOI: 10.1002/stem.1456  0.48
2013 Sequist LV, Yang JC, Yamamoto N, O'Byrne K, Hirsh V, Mok T, Geater SL, Orlov S, Tsai CM, Boyer M, Su WC, Bennouna J, Kato T, Gorbunova V, Lee KH, et al. Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: 3327-34. PMID 23816960 DOI: 10.1200/JCO.2012.44.2806  0.48
2013 Tian X, Azpurua J, Hine C, Vaidya A, Myakishev-Rempel M, Ablaeva J, Mao Z, Nevo E, Gorbunova V, Seluanov A. High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat. Nature. 499: 346-9. PMID 23783513 DOI: 10.1038/nature12234  0.48
2013 Azpurua J, Yang JN, Van Meter M, Liu Z, Kim J, Lobo Ladd AA, Coppi AA, Gorbunova V, Seluanov A. IGF1R levels in the brain negatively correlate with longevity in 16 rodent species. Aging. 5: 304-14. PMID 23651613  0.48
2013 Lordick F, Kang YK, Chung HC, Salman P, Oh SC, Bodoky G, Kurteva G, Volovat C, Moiseyenko VM, Gorbunova V, Park JO, Sawaki A, Celik I, Götte H, Melezínková H, et al. Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): a randomised, open-label phase 3 trial. The Lancet. Oncology. 14: 490-9. PMID 23594786 DOI: 10.1016/S1470-2045(13)70102-5  0.48
2013 Leu JD, Chiu YW, Lo CC, Chiang PH, Chiu SJ, Tsai CH, Hwang JJ, Chen RC, Gorbunova V, Lee YJ. Enhanced cellular radiosensitivity induced by cofilin-1 over-expression is associated with reduced DNA repair capacity. International Journal of Radiation Biology. 89: 433-44. PMID 23362981 DOI: 10.3109/09553002.2013.767992  0.48
2012 Van Meter M, Seluanov A, Gorbunova V.  Forever young?  Exploring the link between rapamycin, longevity and cancer. Cell Cycle (Georgetown, Tex.). 11: 4296-7. PMID 23152185 DOI: 10.4161/cc.22868  0.72
2012 Gorbunova V, Hine C, Tian X, Ablaeva J, Gudkov AV, Nevo E, Seluanov A. Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism. Proceedings of the National Academy of Sciences of the United States of America. 109: 19392-6. PMID 23129611 DOI: 10.1073/pnas.1217211109  0.48
2012 Ramlau R, Gorbunova V, Ciuleanu TE, Novello S, Ozguroglu M, Goksel T, Baldotto C, Bennouna J, Shepherd FA, Le-Guennec S, Rey A, Miller V, Thatcher N, Scagliotti G. Aflibercept and Docetaxel versus Docetaxel alone after platinum failure in patients with advanced or metastatic non-small-cell lung cancer: a randomized, controlled phase III trial. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 3640-7. PMID 22965962 DOI: 10.1200/JCO.2012.42.6932  0.48
2012 Mao Z, Tian X, Van Meter M, Ke Z, Gorbunova V, Seluanov A. Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence. Proceedings of the National Academy of Sciences of the United States of America. 109: 11800-5. PMID 22753495 DOI: 10.1073/pnas.1200583109  0.72
2012 Mao Z, Ke Z, Gorbunova V, Seluanov A. Replicatively senescent cells are arrested in G1 and G2 phases. Aging. 4: 431-5. PMID 22745179  0.72
2012 Anisimov VN, Bartke A, Barzilai N, Batin MA, Blagosklonny MV, Brown-Borg H, Budovskaya Y, Campisi J, Friguet B, Fraifeld V, Franceschi C, Gems D, Gladyshev V, Gorbunova V, Gudkov AV, et al. The second international conference "genetics of aging and longevity". Aging. 4: 305-17. PMID 22661237  0.48
2012 Laskin J, Crinò L, Felip E, Franke F, Gorbunova V, Groen H, Jiang GL, Reck M, Schneider CP. Safety and efficacy of first-line bevacizumab plus chemotherapy in elderly patients with advanced or recurrent nonsquamous non-small cell lung cancer: Safety of avastin in lung trial (MO19390) Journal of Thoracic Oncology. 7: 203-211. PMID 22173662 DOI: 10.1097/JTO.0b013e3182370e02  0.48
2012 Hine CM, Seluanov A, Gorbunova V. Rad51 promoter-targeted gene therapy is effective for in vivo visualization and treatment of cancer. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 347-55. PMID 22008909 DOI: 10.1038/mt.2011.215  0.72
2011 Fong V, Osterbur M, Capella C, Kim YE, Hine C, Gorbunova V, Seluanov A, Dewhurst S. Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells. Plos One. 6: e28714. PMID 22174876 DOI: 10.1371/journal.pone.0028714  0.48
2011 Rini BI, Escudier B, Tomczak P, Kaprin A, Szczylik C, Hutson TE, Michaelson MD, Gorbunova VA, Gore ME, Rusakov IG, Negrier S, Ou YC, Castellano D, Lim HY, Uemura H, et al. Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet (London, England). 378: 1931-9. PMID 22056247 DOI: 10.1016/S0140-6736(11)61613-9  0.48
2011 Van Meter M, Mao Z, Gorbunova V, Seluanov A. Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair. Aging. 3: 829-35. PMID 21946623  0.72
2011 Van Meter M, Mao Z, Gorbunova V, Seluanov A. SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells. Cell Cycle (Georgetown, Tex.). 10: 3153-8. PMID 21900744 DOI: 10.4161/cc.10.18.17435  0.72
2011 Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A, Seluanov A, Gorbunova V. SIRT6 promotes DNA repair under stress by activating PARP1. Science (New York, N.Y.). 332: 1443-6. PMID 21680843 DOI: 10.1126/science.1202723  0.72
2010 Seluanov A, Vaidya A, Gorbunova V. Establishing primary adult fibroblast cultures from rodents. Journal of Visualized Experiments : Jove. PMID 20972406 DOI: 10.3791/2033  0.48
2010 Seluanov A, Mao Z, Gorbunova V. Analysis of DNA double-strand break (DSB) repair in mammalian cells. Journal of Visualized Experiments : Jove. PMID 20864925 DOI: 10.3791/2002  0.72
2009 Seluanov A, Hine C, Azpurua J, Feigenson M, Bozzella M, Mao Z, Catania KC, Gorbunova V. Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat. Proceedings of the National Academy of Sciences of the United States of America. 106: 19352-7. PMID 19858485 DOI: 10.1073/pnas.0905252106  0.48
2009 Jassem J, Pienkowski T, Pluzanska A, Jelic S, Gorbunova V, Berzins J, Nagykalnai T, Biganzoli L, Aloe A, Astier L, Munier S. Doxorubicin and paclitaxel versus fluorouracil, doxorubicin and cyclophosphamide as first-line therapy for women with advanced breast cancer: long-term analysis of the previously published trial. Onkologie. 32: 468-72. PMID 19745590 DOI: 10.1159/000226210  0.48
2009 Mao Z, Jiang Y, Liu X, Seluanov A, Gorbunova V. DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells. Neoplasia (New York, N.Y.). 11: 683-91. PMID 19568413  0.72
2009 Gorbunova V, Seluanov A. Coevolution of telomerase activity and body mass in mammals: from mice to beavers. Mechanisms of Ageing and Development. 130: 3-9. PMID 18387652 DOI: 10.1016/j.mad.2008.02.008  0.72
2008 Gorbunova V, Bozzella MJ, Seluanov A. Rodents for comparative aging studies: from mice to beavers. Age (Dordrecht, Netherlands). 30: 111-9. PMID 19424861 DOI: 10.1007/s11357-008-9053-4  0.72
2008 Hine CM, Seluanov A, Gorbunova V. Use of the Rad51 promoter for targeted anti-cancer therapy. Proceedings of the National Academy of Sciences of the United States of America. 105: 20810-5. PMID 19106292 DOI: 10.1073/pnas.0807990106  0.72
2008 Seluanov A, Hine C, Bozzella M, Hall A, Sasahara TH, Ribeiro AA, Catania KC, Presgraves DC, Gorbunova V. Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan. Aging Cell. 7: 813-23. PMID 18778411 DOI: 10.1111/j.1474-9726.2008.00431.x  0.48
2008 Mao Z, Bozzella M, Seluanov A, Gorbunova V. DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells. Cell Cycle (Georgetown, Tex.). 7: 2902-6. PMID 18769152 DOI: 10.4161/cc.7.18.6679  0.72
2008 Mao Z, Bozzella M, Seluanov A, Gorbunova V. Comparison of nonhomologous end joining and homologous recombination in human cells. Dna Repair. 7: 1765-71. PMID 18675941 DOI: 10.1016/j.dnarep.2008.06.018  0.72
2008 Dion V, Lin Y, Price BA, Fyffe SL, Seluanov A, Gorbunova V, Wilson JH. Genome-wide demethylation promotes triplet repeat instability independently of homologous recombination. Dna Repair. 7: 313-20. PMID 18083071 DOI: 10.1016/j.dnarep.2007.11.002  0.48
2007 Gorbunova V, Seluanov A, Mao Z, Hine C. Changes in DNA repair during aging. Nucleic Acids Research. 35: 7466-74. PMID 17913742 DOI: 10.1093/nar/gkm756  0.72
2007 Seluanov A, Danek J, Hause N, Gorbunova V. Changes in the level and distribution of Ku proteins during cellular senescence. Dna Repair. 6: 1740-8. PMID 17686666 DOI: 10.1016/j.dnarep.2007.06.010  0.48
2007 Mao Z, Seluanov A, Jiang Y, Gorbunova V. TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination. Proceedings of the National Academy of Sciences of the United States of America. 104: 13068-73. PMID 17670947 DOI: 10.1073/pnas.0702410104  0.72
2007 Seluanov A, Chen Z, Hine C, Sasahara TH, Ribeiro AA, Catania KC, Presgraves DC, Gorbunova V. Telomerase activity coevolves with body mass not lifespan. Aging Cell. 6: 45-52. PMID 17173545 DOI: 10.1111/j.1474-9726.2006.00262.x  0.48
2007 Shi X, Seluanov A, Gorbunova V. Cell divisions are required for L1 retrotransposition. Molecular and Cellular Biology. 27: 1264-70. PMID 17145770 DOI: 10.1128/MCB.01888-06  0.72
2005 Gorbunova V, Seluanov A. Making ends meet in old age: DSB repair and aging. Mechanisms of Ageing and Development. 126: 621-8. PMID 15888314 DOI: 10.1016/j.mad.2005.02.008  0.72
2004 Gorbunova V, Seluanov A, Mittelman D, Wilson JH. Genome-wide demethylation destabilizes CTG.CAG trinucleotide repeats in mammalian cells. Human Molecular Genetics. 13: 2979-89. PMID 15459182 DOI: 10.1093/hmg/ddh317  0.72
2004 Seluanov A, Mittelman D, Pereira-Smith OM, Wilson JH, Gorbunova V. DNA end joining becomes less efficient and more error-prone during cellular senescence. Proceedings of the National Academy of Sciences of the United States of America. 101: 7624-9. PMID 15123826 DOI: 10.1073/pnas.0400726101  0.72
2003 Gorbunova V, Seluanov A. Telomerase as a growth-promoting factor. Cell Cycle (Georgetown, Tex.). 2: 534-7. PMID 14504469 DOI: 10.4161/cc.2.6.515  0.72
2003 Gorbunova V, Seluanov A, Dion V, Sandor Z, Meservy JL, Wilson JH. Selectable system for monitoring the instability of CTG/CAG triplet repeats in mammalian cells. Molecular and Cellular Biology. 23: 4485-93. PMID 12808091  0.72
2003 Gorbunova V, Seluanov A, Pereira-Smith OM. Evidence that high telomerase activity may induce a senescent-like growth arrest in human fibroblasts. The Journal of Biological Chemistry. 278: 7692-8. PMID 12496279 DOI: 10.1074/jbc.M212944200  0.72
2002 Gorbunova V, Seluanov A, Pereira-Smith OM. Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis. The Journal of Biological Chemistry. 277: 38540-9. PMID 12140282 DOI: 10.1074/jbc.M202671200  0.72
2002 Gorbunova V, Seluanov A. CLK-1 protein has DNA binding activity specific to O(L) region of mitochondrial DNA. Febs Letters. 516: 279-84. PMID 11959146  0.72
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