Peter Devreotes - Publications

Johns Hopkins University, Baltimore, MD 
Cell Biology, Biochemistry, Toxicology

74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Miao Y, Bhattacharya S, Banerjee T, Abubaker-Sharif B, Long Y, Inoue T, Iglesias PA, Devreotes PN. Wave patterns organize cellular protrusions and control cortical dynamics. Molecular Systems Biology. 15: e8585. PMID 30858181 DOI: 10.15252/msb.20188585  0.36
2018 Miyanaga Y, Kamimura Y, Kuwayama H, Devreotes PN, Ueda M. Chemoattractant receptors activate, recruit and capture G proteins for wide range chemotaxis. Biochemical and Biophysical Research Communications. 507: 304-310. PMID 30454895 DOI: 10.1016/j.bbrc.2018.11.029  0.36
2018 Li X, Edwards M, Swaney KF, Singh N, Bhattacharya S, Borleis J, Long Y, Iglesias PA, Chen J, Devreotes PN. Mutually inhibitory Ras-PI(3,4)P feedback loops mediate cell migration. Proceedings of the National Academy of Sciences of the United States of America. PMID 30194235 DOI: 10.1073/pnas.1809039115  0.36
2018 Edwards M, Cai H, Abubaker-Sharif B, Long Y, Lampert TJ, Devreotes PN. Insight from the maximal activation of the signal transduction excitable network in. Proceedings of the National Academy of Sciences of the United States of America. PMID 29602807 DOI: 10.1073/pnas.1710480115  0.36
2017 Artemenko Y, Devreotes PN. Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation. Journal of Visualized Experiments : Jove. PMID 29155792 DOI: 10.3791/56411  0.36
2017 Lampert TJ, Kamprad N, Edwards M, Borleis J, Watson AJ, Tarantola M, Devreotes PN. Shear force-based genetic screen reveals negative regulators of cell adhesion and protrusive activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 28847951 DOI: 10.1073/pnas.1616600114  0.36
2017 Devreotes PN, Bhattacharya S, Edwards M, Iglesias PA, Lampert T, Miao Y. Excitable Signal Transduction Networks in Directed Cell Migration. Annual Review of Cell and Developmental Biology. PMID 28793794 DOI: 10.1146/annurev-cellbio-100616-060739  0.32
2017 Miao Y, Bhattacharya S, Edwards M, Cai H, Inoue T, Iglesias PA, Devreotes PN. Altering the threshold of an excitable signal transduction network changes cell migratory modes. Nature Cell Biology. PMID 28346441 DOI: 10.1038/ncb3495  0.32
2016 Artemenko Y, Axiotakis L, Borleis J, Iglesias PA, Devreotes PN. Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks. Proceedings of the National Academy of Sciences of the United States of America. PMID 27821730 DOI: 10.1073/pnas.1608767113  0.36
2016 Hoeller O, Toettcher JE, Cai H, Sun Y, Huang CH, Freyre M, Zhao M, Devreotes PN, Weiner OD. Gβ Regulates Coupling between Actin Oscillators for Cell Polarity and Directional Migration. Plos Biology. 14: e1002381. PMID 26890004 DOI: 10.1371/journal.pbio.1002381  0.36
2015 Devreotes P, Horwitz AR. Signaling networks that regulate cell migration. Cold Spring Harbor Perspectives in Biology. 7: a005959. PMID 26238352 DOI: 10.1101/cshperspect.a005959  0.36
2015 Nguyen HN, Yang JM, Miyamoto T, Itoh K, Rho E, Zhang Q, Inoue T, Devreotes PN, Sesaki H, Iijima M. Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN. Scientific Reports. 5: 12600. PMID 26216063 DOI: 10.1038/srep12600  0.36
2015 Swaney KF, Borleis J, Iglesias PA, Devreotes PN. Novel protein Callipygian defines the back of migrating cells. Proceedings of the National Academy of Sciences of the United States of America. 112: E3845-54. PMID 26130809 DOI: 10.1073/pnas.1509098112  0.36
2015 Gao R, Zhao S, Jiang X, Sun Y, Zhao S, Gao J, Borleis J, Willard S, Tang M, Cai H, Kamimura Y, Huang Y, Jiang J, Huang Z, Mogilner A, ... ... Devreotes PN, et al. A large-scale screen reveals genes that mediate electrotaxis in Dictyostelium discoideum. Science Signaling. 8: ra50. PMID 26012633 DOI: 10.1126/scisignal.aab0562  0.36
2015 Yang JM, Nguyen HN, Sesaki H, Devreotes PN, Iijima M. Engineering PTEN function: membrane association and activity. Methods (San Diego, Calif.). 77: 119-24. PMID 25448479 DOI: 10.1016/j.ymeth.2014.10.018  0.36
2014 Wang MJ, Artemenko Y, Cai WJ, Iglesias PA, Devreotes PN. The directional response of chemotactic cells depends on a balance between cytoskeletal architecture and the external gradient. Cell Reports. 9: 1110-21. PMID 25437564 DOI: 10.1016/j.celrep.2014.09.047  0.36
2014 Tang M, Wang M, Shi C, Iglesias PA, Devreotes PN, Huang CH. Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis. Nature Communications. 5: 5175. PMID 25346418 DOI: 10.1038/ncomms6175  0.36
2014 Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, et al. A unified nomenclature and amino acid numbering for human PTEN. Science Signaling. 7: pe15. PMID 24985344 DOI: 10.1126/scisignal.2005560  0.36
2014 Nguyen HN, Yang JM, Afkari Y, Park BH, Sesaki H, Devreotes PN, Iijima M. Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities. Proceedings of the National Academy of Sciences of the United States of America. 111: E2684-93. PMID 24979808 DOI: 10.1073/pnas.1409433111  0.36
2014 Artemenko Y, Lampert TJ, Devreotes PN. Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes. Cellular and Molecular Life Sciences : Cmls. 71: 3711-47. PMID 24846395 DOI: 10.1007/s00018-014-1638-8  0.36
2014 Cai H, Katoh-Kurasawa M, Muramoto T, Santhanam B, Long Y, Li L, Ueda M, Iglesias PA, Shaulsky G, Devreotes PN. Nucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer. Science (New York, N.Y.). 343: 1249531. PMID 24653039 DOI: 10.1126/science.1249531  0.36
2013 Huang CH, Tang M, Shi C, Iglesias PA, Devreotes PN. An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration. Nature Cell Biology. 15: 1307-16. PMID 24142103 DOI: 10.1038/ncb2859  0.36
2013 Roppenser B, Kwon H, Canadien V, Xu R, Devreotes PN, Grinstein S, Brumell JH. Multiple host kinases contribute to Akt activation during Salmonella infection. Plos One. 8: e71015. PMID 23990921 DOI: 10.1371/journal.pone.0071015  0.36
2013 Shi C, Huang CH, Devreotes PN, Iglesias PA. Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells. Plos Computational Biology. 9: e1003122. PMID 23861660 DOI: 10.1371/journal.pcbi.1003122  0.32
2013 Bolduc D, Rahdar M, Tu-Sekine B, Sivakumaren SC, Raben D, Amzel LM, Devreotes P, Gabelli SB, Cole P. Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis. Elife. 2: e00691. PMID 23853711 DOI: 10.7554/eLife.00691  0.36
2013 Zhao S, Gao R, Devreotes PN, Mogilner A, Zhao M. 3D arrays for high throughput assay of cell migration and electrotaxis. Cell Biology International. 37: 995-1002. PMID 23589440 DOI: 10.1002/cbin.10116  0.36
2013 Artemenko Y, Devreotes PN. Hippo on the move: tumor suppressor regulates adhesion and migration. Cell Cycle (Georgetown, Tex.). 12: 535-6. PMID 23370390 DOI: 10.4161/cc.23668  0.36
2012 Artemenko Y, Batsios P, Borleis J, Gagnon Z, Lee J, Rohlfs M, Sanséau D, Willard SS, Schleicher M, Devreotes PN. Tumor suppressor Hippo/MST1 kinase mediates chemotaxis by regulating spreading and adhesion. Proceedings of the National Academy of Sciences of the United States of America. 109: 13632-7. PMID 22847424 DOI: 10.1073/pnas.1211304109  0.36
2012 Galloway JF, Winter A, Lee KH, Park JH, Dvoracek CM, Devreotes P, Searson PC. Quantitative characterization of the lipid encapsulation of quantum dots for biomedical applications. Nanomedicine : Nanotechnology, Biology, and Medicine. 8: 1190-9. PMID 22197728 DOI: 10.1016/j.nano.2011.12.002  0.36
2012 Iglesias PA, Devreotes PN. Biased excitable networks: how cells direct motion in response to gradients. Current Opinion in Cell Biology. 24: 245-53. PMID 22154943 DOI: 10.1016/  0.32
2012 Cai H, Huang CH, Devreotes PN, Iijima M. Analysis of chemotaxis in Dictyostelium. Methods in Molecular Biology (Clifton, N.J.). 757: 451-68. PMID 21909927 DOI: 10.1007/978-1-61779-166-6_26  0.36
2011 Tang M, Iijima M, Devreotes P. Generation of cells that ignore the effects of PIP3 on cytoskeleton. Cell Cycle (Georgetown, Tex.). 10: 2817-8. PMID 21869609 DOI: 10.4161/cc.10.17.16744  0.36
2011 Artemenko Y, Swaney KF, Devreotes PN. Assessment of development and chemotaxis in Dictyostelium discoideum mutants. Methods in Molecular Biology (Clifton, N.J.). 769: 287-309. PMID 21748684 DOI: 10.1007/978-1-61779-207-6_20  0.36
2011 Gao RC, Zhang XD, Sun YH, Kamimura Y, Mogilner A, Devreotes PN, Zhao M. Different roles of membrane potentials in electrotaxis and chemotaxis of dictyostelium cells. Eukaryotic Cell. 10: 1251-6. PMID 21743003 DOI: 10.1128/EC.05066-11  0.36
2011 Tang M, Iijima M, Kamimura Y, Chen L, Long Y, Devreotes P. Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN. Molecular Biology of the Cell. 22: 437-47. PMID 21169559 DOI: 10.1091/mbc.E10-06-0522  0.36
2010 Xiong Y, Huang CH, Iglesias PA, Devreotes PN. Cells navigate with a local-excitation, global-inhibition-biased excitable network. Proceedings of the National Academy of Sciences of the United States of America. 107: 17079-86. PMID 20864631 DOI: 10.1073/pnas.1011271107  0.32
2010 Cai H, Das S, Kamimura Y, Long Y, Parent CA, Devreotes PN. Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis. The Journal of Cell Biology. 190: 233-45. PMID 20660630 DOI: 10.1083/jcb.201001129  0.36
2010 Xiong Y, Kabacoff C, Franca-Koh J, Devreotes PN, Robinson DN, Iglesias PA. Automated characterization of cell shape changes during amoeboid motility by skeletonization Bmc Systems Biology. 4. PMID 20334652 DOI: 10.1186/1752-0509-4-33  0.36
2010 Kamimura Y, Devreotes PN. Phosphoinositide-dependent protein kinase (PDK) activity regulates phosphatidylinositol 3,4,5-trisphosphate-dependent and -independent protein kinase B activation and chemotaxis. The Journal of Biological Chemistry. 285: 7938-46. PMID 20075071 DOI: 10.1074/jbc.M109.089235  0.36
2009 Kamimura Y, Tang M, Devreotes P. Assays for chemotaxis and chemoattractant-stimulated TorC2 activation and PKB substrate phosphorylation in Dictyostelium. Methods in Molecular Biology (Clifton, N.J.). 571: 255-70. PMID 19763972 DOI: 10.1007/978-1-60761-198-1_17  0.36
2009 Rahdar M, Inoue T, Meyer T, Zhang J, Vazquez F, Devreotes PN. A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proceedings of the National Academy of Sciences of the United States of America. 106: 480-5. PMID 19114656 DOI: 10.1073/pnas.0811212106  0.36
2008 Tang L, Franca-Koh J, Xiong Y, Chen MY, Long Y, Bickford RM, Knecht DA, Iglesias PA, Devreotes PN. tsunami, the Dictyostelium homolog of the Fused kinase, is required for polarization and chemotaxis. Genes & Development. 22: 2278-90. PMID 18708585 DOI: 10.1101/gad.1694508  0.36
2008 Kamimura Y, Xiong Y, Iglesias PA, Hoeller O, Bolourani P, Devreotes PN. PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Current Biology : Cb. 18: 1034-43. PMID 18635356 DOI: 10.1016/j.cub.2008.06.068  0.36
2008 Iglesias PA, Devreotes PN. Navigating through models of chemotaxis. Current Opinion in Cell Biology. 20: 35-40. PMID 18207721 DOI: 10.1016/  0.32
2007 Sasaki AT, Janetopoulos C, Lee S, Charest PG, Takeda K, Sundheimer LW, Meili R, Devreotes PN, Firtel RA. G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility. The Journal of Cell Biology. 178: 185-91. PMID 17635933 DOI: 10.1083/jcb.200611138  0.36
2007 Chen L, Iijima M, Tang M, Landree MA, Huang YE, Xiong Y, Iglesias PA, Devreotes PN. PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis. Developmental Cell. 12: 603-14. PMID 17419997 DOI: 10.1016/j.devcel.2007.03.005  0.36
2007 Franca-Koh J, Kamimura Y, Devreotes PN. Leading-edge research: PtdIns(3,4,5)P3 and directed migration. Nature Cell Biology. 9: 15-7. PMID 17199126 DOI: 10.1038/ncb0107-15  0.36
2006 Somesh BP, Neffgen C, Iijima M, Devreotes P, Rivero F. Dictyostelium RacH regulates endocytic vesicular trafficking and is required for localization of vacuolin. Traffic (Copenhagen, Denmark). 7: 1194-212. PMID 17004322  0.36
2006 Willard SS, Devreotes PN. Signaling pathways mediating chemotaxis in the social amoeba, Dictyostelium discoideum. European Journal of Cell Biology. 85: 897-904. PMID 16962888 DOI: 10.1016/j.ejcb.2006.06.003  0.36
2006 Somesh BP, Vlahou G, Iijima M, Insall RH, Devreotes P, Rivero F. RacG regulates morphology, phagocytosis, and chemotaxis. Eukaryotic Cell. 5: 1648-63. PMID 16950926 DOI: 10.1128/EC.00221-06  0.36
2006 Zhao M, Song B, Pu J, Wada T, Reid B, Tai G, Wang F, Guo A, Walczysko P, Gu Y, Sasaki T, Suzuki A, Forrester JV, Bourne HR, Devreotes PN, et al. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature. 442: 457-60. PMID 16871217 DOI: 10.1038/nature04925  0.36
2006 Vazquez F, Devreotes P. Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction. Cell Cycle (Georgetown, Tex.). 5: 1523-7. PMID 16861931 DOI: 10.4161/cc.5.14.3005  0.36
2006 Franca-Koh J, Kamimura Y, Devreotes P. Navigating signaling networks: chemotaxis in Dictyostelium discoideum. Current Opinion in Genetics & Development. 16: 333-8. PMID 16782326 DOI: 10.1016/j.gde.2006.06.001  0.36
2006 Vazquez F, Matsuoka S, Sellers WR, Yanagida T, Ueda M, Devreotes PN. Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane. Proceedings of the National Academy of Sciences of the United States of America. 103: 3633-8. PMID 16537447 DOI: 10.1073/pnas.0510570103  0.36
2006 Matsuoka S, Iijima M, Watanabe TM, Kuwayama H, Yanagida T, Devreotes PN, Ueda M. Single-molecule analysis of chemoattractant-stimulated membrane recruitment of a PH-domain-containing protein. Journal of Cell Science. 119: 1071-9. PMID 16507590 DOI: 10.1242/jcs.02824  0.36
2006 Loovers HM, Postma M, Keizer-Gunnink I, Huang YE, Devreotes PN, van Haastert PJ. Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: a quantitative in vivo analysis by inhibition of PI3-kinase. Molecular Biology of the Cell. 17: 1503-13. PMID 16421252 DOI: 10.1091/mbc.E05-09-0825  0.32
2005 Fache S, Dalous J, Engelund M, Hansen C, Chamaraux F, Fourcade B, Satre M, Devreotes P, Bruckert F. Calcium mobilization stimulates Dictyostelium discoideum shear-flow-induced cell motility Journal of Cell Science. 118: 3445-3457. PMID 16079287 DOI: 10.1242/jcs.02461  0.36
2005 Janetopoulos C, Borleis J, Vazquez F, Iijima M, Devreotes P. Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis. Developmental Cell. 8: 467-77. PMID 15809030 DOI: 10.1016/j.devcel.2005.02.010  0.36
2004 Manahan CL, Iglesias PA, Long Y, Devreotes PN. Chemoattractant signaling in dictyostelium discoideum. Annual Review of Cell and Developmental Biology. 20: 223-53. PMID 15473840 DOI: 10.1146/annurev.cellbio.20.011303.132633  0.36
2004 Ma L, Janetopoulos C, Yang L, Devreotes PN, Iglesias PA. Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in dictyostelium cells. Biophysical Journal. 87: 3764-74. PMID 15465874 DOI: 10.1529/biophysj.104.045484  0.32
2004 Franca-Koh J, Devreotes PN. Moving forward: mechanisms of chemoattractant gradient sensing. Physiology (Bethesda, Md.). 19: 300-8. PMID 15381759 DOI: 10.1152/physiol.00017.2004  0.32
2004 Montell C, Devreotes P. From protein dynamics to animal behavior: new insights into complex cell regulatory mechanisms. Current Opinion in Cell Biology. 16: 115-8. PMID 15196552 DOI: 10.1016/  0.36
2004 Janetopoulos C, Ma L, Devreotes PN, Iglesias PA. Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proceedings of the National Academy of Sciences of the United States of America. 101: 8951-6. PMID 15184679 DOI: 10.1073/pnas.0402152101  0.32
2004 Hynes TR, Tang L, Mervine SM, Sabo JL, Yost EA, Devreotes PN, Berlot CH. Visualization of G protein betagamma dimers using bimolecular fluorescence complementation demonstrates roles for both beta and gamma in subcellular targeting. The Journal of Biological Chemistry. 279: 30279-86. PMID 15136579 DOI: 10.1074/jbc.M401432200  0.36
2004 Kutscher B, Devreotes P, Iglesias PA. Local excitation, global inhibition mechanism for gradient sensing: an interactive applet. Science's Stke : Signal Transduction Knowledge Environment. 2004: pl3. PMID 14872096 DOI: 10.1126/stke.2192004pl3  0.32
2004 Iijima M, Huang YE, Luo HR, Vazquez F, Devreotes PN. Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis. The Journal of Biological Chemistry. 279: 16606-13. PMID 14764604 DOI: 10.1074/jbc.M312098200  0.36
2004 Landree MA, Devreotes PN. Analyzing chemotaxis using Dictyostelium discoideum as a model system. Methods in Molecular Biology (Clifton, N.J.). 239: 91-104. PMID 14573912  0.32
2003 Chen L, Janetopoulos C, Huang YE, Iijima M, Borleis J, Devreotes PN. Two phases of actin polymerization display different dependencies on PI(3,4,5)P3 accumulation and have unique roles during chemotaxis. Molecular Biology of the Cell. 14: 5028-37. PMID 14595116 DOI: 10.1091/mbc.E03-05-0339  0.36
2003 Luo HR, Huang YE, Chen JC, Saiardi A, Iijima M, Ye K, Huang Y, Nagata E, Devreotes P, Snyder SH. Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions. Cell. 114: 559-72. PMID 13678580 DOI: 10.1016/S0092-8674(03)00640-8  0.36
2003 Huang YE, Iijima M, Parent CA, Funamoto S, Firtel RA, Devreotes P. Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells. Molecular Biology of the Cell. 14: 1913-22. PMID 12802064 DOI: 10.1091/mbc.E02-10-0703  0.36
2002 Iijima M, Huang YE, Devreotes P. Temporal and spatial regulation of chemotaxis. Developmental Cell. 3: 469-78. PMID 12408799  0.36
2002 Zhang N, Long Y, Devreotes PN. Ege A, a novel C2 domain containing protein, is essential for GPCR-mediated gene expression in dictyostelium. Developmental Biology. 248: 1-12. PMID 12142016  0.36
2002 Iijima M, Devreotes P. Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell. 109: 599-610. PMID 12062103  0.36
2002 Parent CA, Borleis J, Devreotes PN. Regulation of adenylyl cyclases by a region outside the minimally functional cytoplasmic domains. The Journal of Biological Chemistry. 277: 1354-60. PMID 11694527 DOI: 10.1074/jbc.M106430200  0.36
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