Peter Devreotes - Publications

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Cell Biology, Biochemistry, Toxicology

145 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Zhan H, Bhattacharya S, Cai H, Iglesias PA, Huang CH, Devreotes PN. An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells. Developmental Cell. PMID 32877650 DOI: 10.1016/j.devcel.2020.08.001  0.56
2020 Bhattacharya S, Banerjee T, Miao Y, Zhan H, Devreotes PN, Iglesias PA. Traveling and standing waves mediate pattern formation in cellular protrusions. Science Advances. 6: eaay7682. PMID 32821814 DOI: 10.1126/sciadv.aay7682  0.64
2020 Jiao Z, Cai H, Long Y, Sirka OK, Padmanaban V, Ewald AJ, Devreotes PN. Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects. Proceedings of the National Academy of Sciences of the United States of America. PMID 32051246 DOI: 10.1073/pnas.1917938117  0.36
2019 Cao Y, Ghabache E, Miao Y, Niman C, Hakozaki H, Reck-Peterson SL, Devreotes PN, Rappel WJ. A minimal computational model for three-dimensional cell migration. Journal of the Royal Society, Interface. 16: 20190619. PMID 31847757 DOI: 10.1098/rsif.2019.0619  0.64
2019 Pal DS, Li X, Banerjee T, Miao Y, Devreotes PN. The excitable signal transduction networks: movers and shapers of eukaryotic cell migration. The International Journal of Developmental Biology. 63: 407-416. PMID 31840779 DOI: 10.1387/ijdb.190265pd  0.64
2019 Li X, Miao Y, Pal DS, Devreotes PN. Excitable networks controlling cell migration during development and disease. Seminars in Cell & Developmental Biology. PMID 31836289 DOI: 10.1016/j.semcdb.2019.11.001  0.64
2019 Jeon TJ, Gao R, Kim H, Lee A, Jeon P, Devreotes PN, Zhao M. Cell migration directionality and speed are independently regulated by RasG and Gβ in cells in electrotaxis. Biology Open. PMID 31221628 DOI: 10.1242/bio.042457  0.36
2019 Miao Y, Bhattacharya S, Banerjee T, Abubaker-Sharif B, Long Y, Inoue T, Iglesias PA, Devreotes PN. Wave patterns organize cellular protrusions and control cortical dynamics. Molecular Systems Biology. 15: e8585. PMID 30858181 DOI: 10.15252/msb.20188585  0.64
2018 Miyanaga Y, Kamimura Y, Kuwayama H, Devreotes PN, Ueda M. Chemoattractant receptors activate, recruit and capture G proteins for wide range chemotaxis. Biochemical and Biophysical Research Communications. 507: 304-310. PMID 30454895 DOI: 10.1016/j.bbrc.2018.11.029  0.32
2018 Li X, Edwards M, Swaney KF, Singh N, Bhattacharya S, Borleis J, Long Y, Iglesias PA, Chen J, Devreotes PN. Mutually inhibitory Ras-PI(3,4)P feedback loops mediate cell migration. Proceedings of the National Academy of Sciences of the United States of America. PMID 30194235 DOI: 10.1073/pnas.1809039115  0.56
2018 Edwards M, Cai H, Abubaker-Sharif B, Long Y, Lampert TJ, Devreotes PN. Insight from the maximal activation of the signal transduction excitable network in. Proceedings of the National Academy of Sciences of the United States of America. PMID 29602807 DOI: 10.1073/pnas.1710480115  0.36
2017 Lampert TJ, Kamprad N, Edwards M, Borleis J, Watson AJ, Tarantola M, Devreotes PN. Shear force-based genetic screen reveals negative regulators of cell adhesion and protrusive activity. Proceedings of the National Academy of Sciences of the United States of America. PMID 28847951 DOI: 10.1073/pnas.1616600114  0.56
2017 Devreotes PN, Bhattacharya S, Edwards M, Iglesias PA, Lampert T, Miao Y. Excitable Signal Transduction Networks in Directed Cell Migration. Annual Review of Cell and Developmental Biology. PMID 28793794 DOI: 10.1146/annurev-cellbio-100616-060739  0.64
2017 Schiapparelli P, Guerrero-Cazares H, Magaña-Maldonado R, Hamilla SM, Ganaha S, Goulin Lippi Fernandes E, Huang CH, Aranda-Espinoza H, Devreotes P, Quinones-Hinojosa A. NKCC1 Regulates Migration Ability of Glioblastoma Cells by Modulation of Actin Dynamics and Interacting with Cofilin. Ebiomedicine. PMID 28679472 DOI: 10.1016/j.ebiom.2017.06.020  0.32
2017 Chen Z, Jiang H, Xu W, Li X, Dempsey DR, Zhang X, Devreotes P, Wolberger C, Amzel LM, Gabelli SB, Cole PA. A Tunable Brake for HECT Ubiquitin Ligases. Molecular Cell. 66: 345-357.e6. PMID 28475870 DOI: 10.1016/j.molcel.2017.03.020  0.48
2017 Miao Y, Bhattacharya S, Edwards M, Cai H, Inoue T, Iglesias PA, Devreotes PN. Altering the threshold of an excitable signal transduction network changes cell migratory modes. Nature Cell Biology. PMID 28346441 DOI: 10.1038/ncb3495  0.64
2016 Artemenko Y, Axiotakis L, Borleis J, Iglesias PA, Devreotes PN. Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks. Proceedings of the National Academy of Sciences of the United States of America. PMID 27821730 DOI: 10.1073/pnas.1608767113  0.56
2016 Hoeller O, Toettcher JE, Cai H, Sun Y, Huang CH, Freyre M, Zhao M, Devreotes PN, Weiner OD. Gβ Regulates Coupling between Actin Oscillators for Cell Polarity and Directional Migration. Plos Biology. 14: e1002381. PMID 26890004 DOI: 10.1371/journal.pbio.1002381  0.48
2015 Devreotes P, Horwitz AR. Signaling networks that regulate cell migration. Cold Spring Harbor Perspectives in Biology. 7: a005959. PMID 26238352 DOI: 10.1101/cshperspect.a005959  0.48
2015 Nguyen HN, Yang JM, Miyamoto T, Itoh K, Rho E, Zhang Q, Inoue T, Devreotes PN, Sesaki H, Iijima M. Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN. Scientific Reports. 5: 12600. PMID 26216063 DOI: 10.1038/srep12600  0.56
2015 Santhanam B, Cai H, Devreotes PN, Shaulsky G, Katoh-Kurasawa M. The GATA transcription factor GtaC regulates early developmental gene expression dynamics in Dictyostelium. Nature Communications. 6: 7551. PMID 26144553 DOI: 10.1038/ncomms8551  0.32
2015 Swaney KF, Borleis J, Iglesias PA, Devreotes PN. Novel protein Callipygian defines the back of migrating cells. Proceedings of the National Academy of Sciences of the United States of America. 112: E3845-54. PMID 26130809 DOI: 10.1073/pnas.1509098112  0.56
2015 Gao R, Zhao S, Jiang X, Sun Y, Zhao S, Gao J, Borleis J, Willard S, Tang M, Cai H, Kamimura Y, Huang Y, Jiang J, Huang Z, Mogilner A, ... ... Devreotes PN, et al. A large-scale screen reveals genes that mediate electrotaxis in Dictyostelium discoideum. Science Signaling. 8: ra50. PMID 26012633 DOI: 10.1126/scisignal.aab0562  0.56
2015 Yang JM, Nguyen HN, Sesaki H, Devreotes PN, Iijima M. Engineering PTEN function: membrane association and activity. Methods (San Diego, Calif.). 77: 119-24. PMID 25448479 DOI: 10.1016/j.ymeth.2014.10.018  0.56
2015 Nguyen HN, Yang JM, Rahdar M, Keniry M, Swaney KF, Parsons R, Park BH, Sesaki H, Devreotes PN, Iijima M. A new class of cancer-associated PTEN mutations defined by membrane translocation defects. Oncogene. 34: 3737-43. PMID 25263454 DOI: 10.1038/onc.2014.293  0.48
2015 Nguyen HN, Yang JM, Miyamoto T, Itoh K, Rho E, Zhang Q, Inoue T, Devreotes PN, Sesaki H, Iijima M. Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN Scientific Reports. 5. DOI: 10.1038/srep12600  0.48
2014 Wang MJ, Artemenko Y, Cai WJ, Iglesias PA, Devreotes PN. The directional response of chemotactic cells depends on a balance between cytoskeletal architecture and the external gradient. Cell Reports. 9: 1110-21. PMID 25437564 DOI: 10.1016/j.celrep.2014.09.047  0.56
2014 Tang M, Wang M, Shi C, Iglesias PA, Devreotes PN, Huang CH. Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis. Nature Communications. 5: 5175. PMID 25346418 DOI: 10.1038/ncomms6175  0.56
2014 Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, et al. A unified nomenclature and amino acid numbering for human PTEN. Science Signaling. 7: pe15. PMID 24985344 DOI: 10.1126/scisignal.2005560  0.48
2014 Nguyen HN, Yang JM, Afkari Y, Park BH, Sesaki H, Devreotes PN, Iijima M. Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities. Proceedings of the National Academy of Sciences of the United States of America. 111: E2684-93. PMID 24979808 DOI: 10.1073/pnas.1409433111  0.56
2014 Cai H, Katoh-Kurasawa M, Muramoto T, Santhanam B, Long Y, Li L, Ueda M, Iglesias PA, Shaulsky G, Devreotes PN. Nucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer. Science (New York, N.Y.). 343: 1249531. PMID 24653039 DOI: 10.1126/science.1249531  0.56
2014 Nguyen HN, Afkari Y, Senoo H, Sesaki H, Devreotes PN, Iijima M. Mechanism of human PTEN localization revealed by heterologous expression in Dictyostelium. Oncogene. 33: 5688-96. PMID 24292679 DOI: 10.1038/onc.2013.507  0.56
2014 Zhao S, Gao R, Devreotes PN, Mogilner A, Zhao M. Corrigendum to 3D arrays for high throughput assay of cell migration and electrotaxis [Cell Biol Int 37, 995-1002] Cell Biology International. 38: 987. DOI: 10.1002/cbin.10324  0.48
2013 Huang CH, Tang M, Shi C, Iglesias PA, Devreotes PN. An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration. Nature Cell Biology. 15: 1307-16. PMID 24142103 DOI: 10.1038/ncb2859  0.56
2013 Roppenser B, Kwon H, Canadien V, Xu R, Devreotes PN, Grinstein S, Brumell JH. Multiple host kinases contribute to Akt activation during Salmonella infection. Plos One. 8: e71015. PMID 23990921 DOI: 10.1371/journal.pone.0071015  0.48
2013 Shi C, Huang CH, Devreotes PN, Iglesias PA. Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells. Plos Computational Biology. 9: e1003122. PMID 23861660 DOI: 10.1371/journal.pcbi.1003122  0.56
2013 Bolduc D, Rahdar M, Tu-Sekine B, Sivakumaren SC, Raben D, Amzel LM, Devreotes P, Gabelli SB, Cole P. Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis. Elife. 2: e00691. PMID 23853711 DOI: 10.7554/eLife.00691  0.48
2013 Zhao S, Gao R, Devreotes PN, Mogilner A, Zhao M. 3D arrays for high throughput assay of cell migration and electrotaxis. Cell Biology International. 37: 995-1002. PMID 23589440 DOI: 10.1002/cbin.10116  0.48
2012 Artemenko Y, Batsios P, Borleis J, Gagnon Z, Lee J, Rohlfs M, Sanséau D, Willard SS, Schleicher M, Devreotes PN. Tumor suppressor Hippo/MST1 kinase mediates chemotaxis by regulating spreading and adhesion. Proceedings of the National Academy of Sciences of the United States of America. 109: 13632-7. PMID 22847424 DOI: 10.1073/pnas.1211304109  0.48
2012 Galloway JF, Winter A, Lee KH, Park JH, Dvoracek CM, Devreotes P, Searson PC. Quantitative characterization of the lipid encapsulation of quantum dots for biomedical applications. Nanomedicine : Nanotechnology, Biology, and Medicine. 8: 1190-9. PMID 22197728 DOI: 10.1016/j.nano.2011.12.002  0.48
2012 Iglesias PA, Devreotes PN. Biased excitable networks: how cells direct motion in response to gradients. Current Opinion in Cell Biology. 24: 245-53. PMID 22154943 DOI: 10.1016/j.ceb.2011.11.009  0.56
2012 Cai H, Huang CH, Devreotes PN, Iijima M. Analysis of chemotaxis in Dictyostelium. Methods in Molecular Biology (Clifton, N.J.). 757: 451-68. PMID 21909927 DOI: 10.1007/978-1-61779-166-6_26  0.56
2011 Tang M, Iijima M, Devreotes P. Generation of cells that ignore the effects of PIP3 on cytoskeleton. Cell Cycle (Georgetown, Tex.). 10: 2817-8. PMID 21869609 DOI: 10.4161/cc.10.17.16744  0.56
2011 Cai H, Devreotes PN. Moving in the right direction: how eukaryotic cells migrate along chemical gradients. Seminars in Cell & Developmental Biology. 22: 834-41. PMID 21821139 DOI: 10.1016/j.semcdb.2011.07.020  0.32
2011 Artemenko Y, Swaney KF, Devreotes PN. Assessment of development and chemotaxis in Dictyostelium discoideum mutants. Methods in Molecular Biology (Clifton, N.J.). 769: 287-309. PMID 21748684 DOI: 10.1007/978-1-61779-207-6_20  0.32
2011 Gao RC, Zhang XD, Sun YH, Kamimura Y, Mogilner A, Devreotes PN, Zhao M. Different roles of membrane potentials in electrotaxis and chemotaxis of dictyostelium cells. Eukaryotic Cell. 10: 1251-6. PMID 21743003 DOI: 10.1128/EC.05066-11  0.48
2011 de Keijzer S, Galloway J, Harms GS, Devreotes PN, Iglesias PA. Disrupting microtubule network immobilizes amoeboid chemotactic receptor in the plasma membrane. Biochimica Et Biophysica Acta. 1808: 1701-8. PMID 21334306 DOI: 10.1016/j.bbamem.2011.02.009  0.56
2011 Tang M, Iijima M, Kamimura Y, Chen L, Long Y, Devreotes P. Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN. Molecular Biology of the Cell. 22: 437-47. PMID 21169559 DOI: 10.1091/mbc.E10-06-0522  0.56
2010 Xiong Y, Huang CH, Iglesias PA, Devreotes PN. Cells navigate with a local-excitation, global-inhibition-biased excitable network. Proceedings of the National Academy of Sciences of the United States of America. 107: 17079-86. PMID 20864631 DOI: 10.1073/pnas.1011271107  0.56
2010 Cai H, Das S, Kamimura Y, Long Y, Parent CA, Devreotes PN. Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis. The Journal of Cell Biology. 190: 233-45. PMID 20660630 DOI: 10.1083/jcb.201001129  0.36
2010 Xiong Y, Kabacoff C, Franca-Koh J, Devreotes PN, Robinson DN, Iglesias PA. Automated characterization of cell shape changes during amoeboid motility by skeletonization Bmc Systems Biology. 4. PMID 20334652 DOI: 10.1186/1752-0509-4-33  0.48
2010 Swaney KF, Huang CH, Devreotes PN. Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity. Annual Review of Biophysics. 39: 265-89. PMID 20192768 DOI: 10.1146/annurev.biophys.093008.131228  0.32
2010 Kamimura Y, Devreotes PN. Phosphoinositide-dependent protein kinase (PDK) activity regulates phosphatidylinositol 3,4,5-trisphosphate-dependent and -independent protein kinase B activation and chemotaxis. The Journal of Biological Chemistry. 285: 7938-46. PMID 20075071 DOI: 10.1074/jbc.M109.089235  0.32
2010 Franca-Koh J, Willard SS, Devreotes PN. G-protein signaling in chemotaxis Handbook of Cell Signaling, 2/E. 2: 1705-1712. DOI: 10.1016/B978-0-12-374145-5.00207-2  0.48
2009 Kamimura Y, Tang M, Devreotes P. Assays for chemotaxis and chemoattractant-stimulated TorC2 activation and PKB substrate phosphorylation in Dictyostelium. Methods in Molecular Biology (Clifton, N.J.). 571: 255-70. PMID 19763972 DOI: 10.1007/978-1-60761-198-1_17  0.56
2009 Rahdar M, Inoue T, Meyer T, Zhang J, Vazquez F, Devreotes PN. A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proceedings of the National Academy of Sciences of the United States of America. 106: 480-5. PMID 19114656 DOI: 10.1073/pnas.0811212106  0.48
2008 Tang L, Franca-Koh J, Xiong Y, Chen MY, Long Y, Bickford RM, Knecht DA, Iglesias PA, Devreotes PN. tsunami, the Dictyostelium homolog of the Fused kinase, is required for polarization and chemotaxis. Genes & Development. 22: 2278-90. PMID 18708585 DOI: 10.1101/gad.1694508  0.48
2008 Kamimura Y, Xiong Y, Iglesias PA, Hoeller O, Bolourani P, Devreotes PN. PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis. Current Biology : Cb. 18: 1034-43. PMID 18635356 DOI: 10.1016/j.cub.2008.06.068  0.56
2008 Iglesias PA, Devreotes PN. Navigating through models of chemotaxis. Current Opinion in Cell Biology. 20: 35-40. PMID 18207721 DOI: 10.1016/j.ceb.2007.11.011  0.56
2007 Sasaki AT, Janetopoulos C, Lee S, Charest PG, Takeda K, Sundheimer LW, Meili R, Devreotes PN, Firtel RA. G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility. The Journal of Cell Biology. 178: 185-91. PMID 17635933 DOI: 10.1083/jcb.200611138  0.48
2007 Chen L, Iijima M, Tang M, Landree MA, Huang YE, Xiong Y, Iglesias PA, Devreotes PN. PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis. Developmental Cell. 12: 603-14. PMID 17419997 DOI: 10.1016/j.devcel.2007.03.005  0.56
2007 Franca-Koh J, Kamimura Y, Devreotes PN. Leading-edge research: PtdIns(3,4,5)P3 and directed migration. Nature Cell Biology. 9: 15-7. PMID 17199126 DOI: 10.1038/ncb0107-15  0.36
2006 Somesh BP, Neffgen C, Iijima M, Devreotes P, Rivero F. Dictyostelium RacH regulates endocytic vesicular trafficking and is required for localization of vacuolin. Traffic (Copenhagen, Denmark). 7: 1194-212. PMID 17004322  0.56
2006 Willard SS, Devreotes PN. Signaling pathways mediating chemotaxis in the social amoeba, Dictyostelium discoideum. European Journal of Cell Biology. 85: 897-904. PMID 16962888 DOI: 10.1016/j.ejcb.2006.06.003  0.48
2006 Somesh BP, Vlahou G, Iijima M, Insall RH, Devreotes P, Rivero F. RacG regulates morphology, phagocytosis, and chemotaxis. Eukaryotic Cell. 5: 1648-63. PMID 16950926 DOI: 10.1128/EC.00221-06  0.56
2006 Janetopoulos C, Devreotes P. Phosphoinositide signaling plays a key role in cytokinesis. The Journal of Cell Biology. 174: 485-90. PMID 16908667 DOI: 10.1083/jcb.200603156  0.56
2006 Zhao M, Song B, Pu J, Wada T, Reid B, Tai G, Wang F, Guo A, Walczysko P, Gu Y, Sasaki T, Suzuki A, Forrester JV, Bourne HR, Devreotes PN, et al. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature. 442: 457-60. PMID 16871217 DOI: 10.1038/nature04925  0.48
2006 Vazquez F, Devreotes P. Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction. Cell Cycle (Georgetown, Tex.). 5: 1523-7. PMID 16861931 DOI: 10.4161/cc.5.14.3005  0.48
2006 Franca-Koh J, Kamimura Y, Devreotes P. Navigating signaling networks: chemotaxis in Dictyostelium discoideum. Current Opinion in Genetics & Development. 16: 333-8. PMID 16782326 DOI: 10.1016/j.gde.2006.06.001  0.36
2006 Vazquez F, Matsuoka S, Sellers WR, Yanagida T, Ueda M, Devreotes PN. Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane. Proceedings of the National Academy of Sciences of the United States of America. 103: 3633-8. PMID 16537447 DOI: 10.1073/pnas.0510570103  0.48
2006 Matsuoka S, Iijima M, Watanabe TM, Kuwayama H, Yanagida T, Devreotes PN, Ueda M. Single-molecule analysis of chemoattractant-stimulated membrane recruitment of a PH-domain-containing protein. Journal of Cell Science. 119: 1071-9. PMID 16507590 DOI: 10.1242/jcs.02824  0.56
2006 Loovers HM, Postma M, Keizer-Gunnink I, Huang YE, Devreotes PN, van Haastert PJ. Distinct roles of PI(3,4,5)P3 during chemoattractant signaling in Dictyostelium: a quantitative in vivo analysis by inhibition of PI3-kinase. Molecular Biology of the Cell. 17: 1503-13. PMID 16421252 DOI: 10.1091/mbc.E05-09-0825  0.56
2005 Fache S, Dalous J, Engelund M, Hansen C, Chamaraux F, Fourcade B, Satre M, Devreotes P, Bruckert F. Calcium mobilization stimulates Dictyostelium discoideum shear-flow-induced cell motility Journal of Cell Science. 118: 3445-3457. PMID 16079287 DOI: 10.1242/jcs.02461  0.48
2005 Janetopoulos C, Borleis J, Vazquez F, Iijima M, Devreotes P. Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis. Developmental Cell. 8: 467-77. PMID 15809030 DOI: 10.1016/j.devcel.2005.02.010  0.56
2004 Manahan CL, Iglesias PA, Long Y, Devreotes PN. Chemoattractant signaling in dictyostelium discoideum. Annual Review of Cell and Developmental Biology. 20: 223-53. PMID 15473840 DOI: 10.1146/annurev.cellbio.20.011303.132633  0.56
2004 Ma L, Janetopoulos C, Yang L, Devreotes PN, Iglesias PA. Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in dictyostelium cells. Biophysical Journal. 87: 3764-74. PMID 15465874 DOI: 10.1529/biophysj.104.045484  0.56
2004 Franca-Koh J, Devreotes PN. Moving forward: mechanisms of chemoattractant gradient sensing. Physiology (Bethesda, Md.). 19: 300-8. PMID 15381759 DOI: 10.1152/physiol.00017.2004  0.36
2004 Van Haastert PJ, Devreotes PN. Chemotaxis: signalling the way forward. Nature Reviews. Molecular Cell Biology. 5: 626-34. PMID 15366706 DOI: 10.1038/nrm1435  0.32
2004 Montell C, Devreotes P. From protein dynamics to animal behavior: new insights into complex cell regulatory mechanisms. Current Opinion in Cell Biology. 16: 115-8. PMID 15196552 DOI: 10.1016/j.ceb.2004.02.011  0.48
2004 Janetopoulos C, Ma L, Devreotes PN, Iglesias PA. Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton. Proceedings of the National Academy of Sciences of the United States of America. 101: 8951-6. PMID 15184679 DOI: 10.1073/pnas.0402152101  0.56
2004 Hynes TR, Tang L, Mervine SM, Sabo JL, Yost EA, Devreotes PN, Berlot CH. Visualization of G protein betagamma dimers using bimolecular fluorescence complementation demonstrates roles for both beta and gamma in subcellular targeting. The Journal of Biological Chemistry. 279: 30279-86. PMID 15136579 DOI: 10.1074/jbc.M401432200  0.48
2004 Kutscher B, Devreotes P, Iglesias PA. Local excitation, global inhibition mechanism for gradient sensing: an interactive applet. Science's Stke : Signal Transduction Knowledge Environment. 2004: pl3. PMID 14872096 DOI: 10.1126/stke.2192004pl3  0.56
2004 Iijima M, Huang YE, Luo HR, Vazquez F, Devreotes PN. Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis. The Journal of Biological Chemistry. 279: 16606-13. PMID 14764604 DOI: 10.1074/jbc.M312098200  0.56
2004 Landree MA, Devreotes PN. Analyzing chemotaxis using Dictyostelium discoideum as a model system. Methods in Molecular Biology (Clifton, N.J.). 239: 91-104. PMID 14573912  0.56
2003 Chen L, Janetopoulos C, Huang YE, Iijima M, Borleis J, Devreotes PN. Two phases of actin polymerization display different dependencies on PI(3,4,5)P3 accumulation and have unique roles during chemotaxis. Molecular Biology of the Cell. 14: 5028-37. PMID 14595116 DOI: 10.1091/mbc.E03-05-0339  0.56
2003 Luo HR, Huang YE, Chen JC, Saiardi A, Iijima M, Ye K, Huang Y, Nagata E, Devreotes P, Snyder SH. Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions. Cell. 114: 559-72. PMID 13678580 DOI: 10.1016/S0092-8674(03)00640-8  0.48
2003 Huang YE, Iijima M, Parent CA, Funamoto S, Firtel RA, Devreotes P. Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells. Molecular Biology of the Cell. 14: 1913-22. PMID 12802064 DOI: 10.1091/mbc.E02-10-0703  0.48
2003 Devreotes P, Janetopoulos C. Eukaryotic chemotaxis: distinctions between directional sensing and polarization. The Journal of Biological Chemistry. 278: 20445-8. PMID 12672811 DOI: 10.1074/jbc.R300010200  0.56
2002 Iijima M, Huang YE, Devreotes P. Temporal and spatial regulation of chemotaxis. Developmental Cell. 3: 469-78. PMID 12408799  0.56
2002 Janetopoulos C, Devreotes P. Monitoring receptor-mediated activation of heterotrimeric G-proteins by fluorescence resonance energy transfer. Methods (San Diego, Calif.). 27: 366-73. PMID 12217653  0.56
2002 Dormann D, Weijer G, Parent CA, Devreotes PN, Weijer CJ. Visualizing PI3 kinase-mediated cell-cell signaling during Dictyostelium development. Current Biology : Cb. 12: 1178-88. PMID 12176327  0.36
2002 Zhang N, Long Y, Devreotes PN. Ege A, a novel C2 domain containing protein, is essential for GPCR-mediated gene expression in dictyostelium. Developmental Biology. 248: 1-12. PMID 12142016  0.36
2002 Iijima M, Devreotes P. Tumor suppressor PTEN mediates sensing of chemoattractant gradients. Cell. 109: 599-610. PMID 12062103  0.56
2002 Zhao M, Jin T, McCaig CD, Forrester JV, Devreotes PN. Genetic analysis of the role of G protein-coupled receptor signaling in electrotaxis. The Journal of Cell Biology. 157: 921-7. PMID 12045182 DOI: 10.1083/jcb.200112070  0.4
2002 Bankir L, Ahloulay M, Devreotes PN, Parent CA. Extracellular cAMP inhibits proximal reabsorption: are plasma membrane cAMP receptors involved? American Journal of Physiology. Renal Physiology. 282: F376-92. PMID 11832418 DOI: 10.1152/ajprenal.00202.2001  0.36
2002 Parent CA, Borleis J, Devreotes PN. Regulation of adenylyl cyclases by a region outside the minimally functional cytoplasmic domains. The Journal of Biological Chemistry. 277: 1354-60. PMID 11694527 DOI: 10.1074/jbc.M106430200  0.56
2002 Zhang N, Long Y, Devreotes PN. Ggamma in dictyostelium: its role in localization of gbetagamma to the membrane is required for chemotaxis in shallow gradients. Molecular Biology of the Cell. 12: 3204-13. PMID 11598203 DOI: 10.1091/MBC.12.10.3204  0.36
2001 Briscoe C, Moniakis J, Kim JY, Brown JM, Hereld D, Devreotes PN, Firtel RA. The phosphorylated C-terminus of cAR1 plays a role in cell-type-specific gene expression and STATa tyrosine phosphorylation. Developmental Biology. 233: 225-36. PMID 11319871 DOI: 10.1006/dbio.2001.0217  0.48
1998 Vithalani KK, Parent CA, Thorn EM, Penn M, Larochelle DA, Devreotes PN, De Lozanne A. Identification of darlin, a Dictyostelium protein with Armadillo-like repeats that binds to small GTPases and is important for the proper aggregation of developing cells. Molecular Biology of the Cell. 9: 3095-106. PMID 9802899 DOI: 10.1091/mbc.9.11.3095  0.48
1998 Jin T, Amzel M, Devreotes PN, Wu L. Selection of Gβ subunits with point mutations that fail to activate specific signaling pathways in vivo: Dissecting cellular responses mediated by a heterotrimeric G protein in Dictyostelium discoideum Molecular Biology of the Cell. 9: 2949-2961. PMID 9763454 DOI: 10.1091/mbc.9.10.2949  0.48
1997 Zigmond SH, Joyce M, Borleis J, Bokoch GM, Devreotes PN. Regulation of actin polymerization in cell-free systems by GTPgammaS and Cdc42. The Journal of Cell Biology. 138: 363-74. PMID 9230078 DOI: 10.1083/jcb.138.2.363  0.48
1997 Mann SK, Brown JM, Briscoe C, Parent C, Pitt G, Devreotes PN, Firtel RA. Role of cAMP-dependent protein kinase in controlling aggregation and postaggregative development in Dictyostelium. Developmental Biology. 183: 208-21. PMID 9126295 DOI: 10.1006/dbio.1996.8499  0.48
1997 Aubry L, Maeda M, Insall R, Devreotes PN, Firtel RA. The Dictyostelium mitogen-activated protein kinase ERK2 is regulated by Ras and cAMP-dependent protein kinase (PKA) and mediates PKA function. The Journal of Biological Chemistry. 272: 3883-6. PMID 9020088 DOI: 10.1074/jbc.272.7.3883  0.48
1997 Insall RH, Borleis J, Devreotes PN. The aimless RasGEF is required for processing of chemotactic signals through G-protein-coupled receptors in Dictyostelium. Current Biology : Cb. 6: 719-29. PMID 8793298 DOI: 10.1016/S0960-9822(09)00453-9  0.56
1996 Chen MY, Insall RH, Devreotes PN. Signaling through chemoattractant receptors in Dictyostelium. Trends in Genetics : Tig. 12: 52-7. PMID 8851971 DOI: 10.1016/0168-9525(96)81400-4  0.52
1996 Maeda M, Aubry L, Insall R, Gaskins C, Devreotes PN, Firtel RA. Seven helix chemoattractant receptors transiently stimulate mitogen-activated protein kinase in Dictyostelium. Role of heterotrimeric G proteins. The Journal of Biological Chemistry. 271: 3351-4. PMID 8631932 DOI: 10.1074/jbc.271.7.3351  0.48
1995 Caterina MJ, Devreotes PN, Borleis J, Hereld D. Agonist-induced loss of ligand binding is correlated with phosphorylation of cAR1, a G protein-coupled chemoattractant receptor from Dictyostelium. The Journal of Biological Chemistry. 270: 8667-72. PMID 7721769 DOI: 10.1074/jbc.270.15.8667  0.56
1995 Milne JL, Wu L, Caterina MJ, Devreotes PN. Seven helix cAMP receptors stimulate Ca2+ entry in the absence of functional G proteins in Dictyostelium. The Journal of Biological Chemistry. 270: 5926-31. PMID 7534302 DOI: 10.1074/jbc.270.11.5926  0.4
1994 Insall R, Kuspa A, Lilly PJ, Shaulsky G, Levin LR, Loomis WF, Devreotes P. CRAC, a cytosolic protein containing a pleckstrin homology domain, is required for receptor and G protein-mediated activation of adenylyl cyclase in Dictyostelium Journal of Cell Biology. 126: 1537-1545. PMID 8089184  0.48
1994 Wu L, Gaskins C, Zhou K, Firtel RA, Devreotes PN. Cloning and targeted mutations of G alpha 7 and G alpha 8, two developmentally regulated G protein alpha-subunit genes in Dictyostelium. Molecular Biology of the Cell. 5: 691-702. PMID 7949425  0.48
1993 Milne JL, Devreotes PN. The surface cyclic AMP receptors, cAR1, cAR2, and cAR3, promote Ca2+ influx in dictyostelium discoideum by a Gα2-independent mechanism Molecular Biology of the Cell. 4: 283-292. PMID 8485319 DOI: 10.1091/mbc.4.3.283  0.48
1993 Saxe CL, Ginsburg GT, Louis JM, Johnson R, Devreotes PN, Kimmel AR. CAR2, a prestalk cAMP receptor required for normal tip formation and late development of Dictyostelium discoideum. Genes & Development. 7: 262-72. PMID 8436297  0.48
1993 Johnson RL, Saxe CL, Gollop R, Kimmel AR, Devreotes PN. Identification and targeted gene disruption of cAR3, a cAMP receptor subtype expressed during multicellular stages of Dictyostelium development. Genes & Development. 7: 273-82. PMID 8382181  0.48
1993 Lilly P, Wu L, Welker DL, Devreotes PN. A G-protein β-subunit is essential for Dictyostelium development Genes and Development. 7: 986-995. PMID 8099335 DOI: 10.1101/gad.7.6.986  0.48
1992 Pitt GS, Milona N, Borleis J, Lin KC, Reed RR, Devreotes PN. Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development. Cell. 69: 305-15. PMID 1348970 DOI: 10.1016/0092-8674(92)90411-5  0.48
1992 Johnson RL, Gundersen R, Hereld D, Pitt GS, Tugendreich S, Saxe CL, Kimmel AR, Devreotes PN. G-protein-linked signaling pathways mediate development in Dictyostelium. Cold Spring Harbor Symposia On Quantitative Biology. 57: 169-76. PMID 1339656 DOI: 10.1101/SQB.1992.057.01.022  0.48
1991 Saxe CL, Johnson R, Devreotes PN, Kimmel AR. Multiple genes for cell surface cAMP receptors in Dictyostelium discoideum. Developmental Genetics. 12: 6-13. PMID 2049880 DOI: 10.1002/dvg.1020120104  0.48
1991 Saxe CL, Johnson RL, Devreotes PN, Kimmel AR. Expression of a cAMP receptor gene of Dictyostelium and evidence for a multigene family. Genes & Development. 5: 1-8. PMID 1989903  0.48
1991 Johnson RL, Vaughan RA, Caterina MJ, Van Haastert PJ, Devreotes PN. Overexpression of the cAMP receptor 1 in growing Dictyostelium cells. Biochemistry. 30: 6982-6. PMID 1648967 DOI: 10.1021/bi00242a025  0.32
1990 Gundersen RE, Devreotes PN. In vivo receptor-mediated phosphorylation of a G protein in Dictyostelium Science. 248: 591-593. PMID 2110382 DOI: 10.1126/science.2110382  0.48
1989 Firtel RA, van Haastert PJM, Kimmel AR, Devreotes PN. G protein linked signal transduction pathways in development: Dictyostelium as an experimental system Cell. 58: 235-239. PMID 2546676 DOI: 10.1016/0092-8674(89)90837-4  0.48
1989 Pupillo M, Kumagai A, Pitt GS, Firtel RA, Devreotes PN. Multiple alpha subunits of guanine nucleotide-binding proteins in Dictyostelium Proceedings of the National Academy of Sciences of the United States of America. 86: 4892-4896. PMID 2500658  0.48
1988 Saxe CL, Klein P, Sun TJ, Kimmel AR, Devreotes PN. Structure and expression of the cAMP cell-surface receptor. Developmental Genetics. 9: 227-35. PMID 3243022 DOI: 10.1002/dvg.1020090405  0.48
1988 Kumagai A, Mann SKO, Pupillo M, Pitt G, Devreotes PN, Firtel RA. A molecular analysis of G proteins and control of early gene expression by the cell-surface cAMP receptor in Dictyostelium Cold Spring Harbor Symposia On Quantitative Biology. 53: 675-685. PMID 3151182  0.48
1988 Pupillo M, Klein P, Vaughan R, Pitt G, Lilly P, Sun T, Devreotes P, Kumagai A, Firtel R. cAMP receptor and G-protein interactions control development in Dictyostelium Cold Spring Harbor Symposia On Quantitative Biology. 53: 657-665. PMID 3151181  0.48
1988 Klein PS, Sun TJ, Saxe CL, Kimmel AR, Johnson RL, Devreotes PN. A chemoattractant receptor controls development in Dictyostelium discoideum. Science (New York, N.Y.). 241: 1467-72. PMID 3047871  0.48
1988 Devreotes PN, Zigmond SH. Chemotaxis in eukaryotic cells: a focus on leukocytes and Dictyostelium. Annual Review of Cell Biology. 4: 649-86. PMID 2848555 DOI: 10.1146/annurev.cb.04.110188.003245  0.48
1988 Klein P, Theibert A, Devreotes P. [25] Identification and ligand-induced modification of the cAMP receptor in Dictyostelium Methods in Enzymology. 159: 267-278. PMID 2842593 DOI: 10.1016/0076-6879(88)59027-4  0.48
1987 Devreotes P, Fontana D, Klein P, Sherring J, Theibert A. Chapter 17 Transmembrane Signaling in Dictyostelium Methods in Cell Biology. 28: 299-331. PMID 3037274 DOI: 10.1016/S0091-679X(08)61653-2  0.48
1986 Segel LA, Goldbeter A, Devreotes PN, Knox BE. A mechanism for exact sensory adaptation based on receptor modification Journal of Theoretical Biology. 120: 151-179. PMID 3784578 DOI: 10.1016/S0022-5193(86)80171-0  0.48
1986 Reymond CD, Gomer RH, Nellen W, Theibert A, Devreotes P, Firtel RA. Phenotypic changes induced by a mutated ras gene during the development of Dictyostelium transformants Nature. 323: 340-343. PMID 3093890 DOI: 10.1038/323340a0  0.48
1986 Knox BE, Devreotes PN, Goldbeter A, Segel LA. A molecular mechanism for sensory adaptation based on ligand-induced receptor modification Proceedings of the National Academy of Sciences of the United States of America. 83: 2345-2349. PMID 3010308  0.48
1986 Theibert A, Palmisano M, Jastorff B, Devreotes P. The specificity of the cAMP receptor mediating activation of adenylate cyclase in Dictyostelium discoideum Developmental Biology. 114: 529-533. PMID 3007244 DOI: 10.1016/0012-1606(86)90216-2  0.48
1986 Theibert A, Fontana D, Wong TY, Devreotes P. Cell-cell interactions in the development of Dictyostelium Integrative and Comparative Biology. 26: 549-552. DOI: 10.1093/icb/26.3.549  0.48
1984 Theibert A, Devreotes PN. Adenosine and its derivatives inhibit the cAMP signaling response in Dictyostelium discoideum Developmental Biology. 106: 166-173. PMID 6092178 DOI: 10.1016/0012-1606(84)90072-1  0.48
1983 Theibert A, Devreotes PN. Cyclic 3',5'-AMP relay in Dictyostelium discoideum: Adaptation is independent of activation of adenylate cyclase Journal of Cell Biology. 97: 173-177. PMID 6306013 DOI: 10.1083/jcb.97.1.173  0.48
1980 Dinauer MC, Steck TL, Devreotes PN. Cyclic 3',5'-AMP relay in Dictyostelium discoideum V. Adaptation of the cAMP signaling response during cAMP stimulation. The Journal of Cell Biology. 86: 554-61. PMID 6249827 DOI: 10.1083/jcb.86.2.554  0.48
1980 Dinauer MC, Steck TL, Devreotes PN. Cyclic 3',5'-AMP relay in Dictyostelium discoideum IV. Recovery of the cAMP signaling response after adaptation to cAMP. The Journal of Cell Biology. 86: 545-53. PMID 6249826 DOI: 10.1083/jcb.86.2.545  0.48
1979 Fambrough DM, Devreotes PN, Gardner JM, Card DJ. The life history of acetylcholine receptors. Progress in Brain Research. 49: 325-34. PMID 390609 DOI: 10.1016/S0079-6123(08)64644-0  0.48
1979 Devreotes PN, Steck TL. Cyclic 3',5' AMP relay in Dictyostelium discoideum. II. Requirements for the initiation and termination of the response. The Journal of Cell Biology. 80: 300-9. PMID 222770  0.48
1979 Devreotes PN, Derstine PL, Steck TL. Cyclic 3',5' AMP relay in Dictyostelium discoideum. I. A technique to monitor responses to controlled stimuli. The Journal of Cell Biology. 80: 291-9. PMID 222769  0.48
1978 Fambrough DM, Devreotes PN. Newly synthesized acetylcholine receptors are located in the Golgi apparatus. The Journal of Cell Biology. 76: 237-44. PMID 563402 DOI: 10.1083/jcb.76.1.237  0.48
1977 Devreotes PN, Gardner JM, Fambrough DM. Kinetics of biosynthesis of acetylcholine receptor and subsequent incorporation into plasma membrane of cultured chick skeletal muscle. Cell. 10: 365-73. PMID 844098 DOI: 10.1016/0092-8674(77)90023-X  0.48
1976 Devreotes PN, Fambrough DM. Synthesis of acetylcholine receptors by cultured chick myotubes and denervated mouse extensor digitorum longus muscles. Proceedings of the National Academy of Sciences of the United States of America. 73: 161-4. PMID 1061111 DOI: 10.1073/pnas.73.1.161  0.48
1975 Devreotes PN, Fambrough DM. Acetylcholine receptor turnover in membranes of developing muscle fibers. The Journal of Cell Biology. 65: 335-58. PMID 236319 DOI: 10.1083/jcb.65.2.335  0.48
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