William B. Isaacs - Publications

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Pharmacology, Biochemistry, Molecular Biology, Oncology, Radiology

114 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Porter CM, Haffner MC, Kulac I, Maynard JP, Baena-Del Valle JA, Isaacs WB, Yegnasubramanian S, De Marzo AM, Sfanos KS. Lactoferrin CpG Island Hypermethylation and Decoupling of mRNA and Protein Expression in the Early Stages of Prostate Carcinogenesis. The American Journal of Pathology. PMID 31499027 DOI: 10.1016/j.ajpath.2019.07.016  0.96
2019 Langston ME, Bhalla A, Alderete JF, Nevin RL, Pakpahan R, Hansen J, Elliott D, De Marzo AM, Gaydos CA, Isaacs WB, Nelson WG, Sokoll LJ, Zenilman JM, Platz EA, Sutcliffe S. Trichomonas vaginalis infection and prostate-specific antigen concentration: Insights into prostate involvement and prostate disease risk. The Prostate. PMID 31376187 DOI: 10.1002/pros.23886  0.64
2019 Zarif JC, Baena-Del Valle JA, Hicks JL, Heaphy CM, Vidal I, Luo J, Lotan TL, Hooper JE, Isaacs WB, Pienta KJ, De Marzo AM. Mannose Receptor-positive Macrophage Infiltration Correlates with Prostate Cancer Onset and Metastatic Castration-resistant Disease. European Urology Oncology. 2: 429-436. PMID 31277779 DOI: 10.1016/j.euo.2018.09.014  0.64
2018 Johng D, Torga G, Ewing CM, Jin K, Norris JD, McDonnell DP, Isaacs WB. HOXB13 interaction with MEIS1 modifies proliferation and gene expression in prostate cancer. The Prostate. PMID 30560549 DOI: 10.1002/pros.23747  0.4
2018 Mottahedeh J, Haffner MC, Grogan TR, Hashimoto T, Crowell PD, Beltran H, Sboner A, Bareja R, Esopi D, Isaacs WB, Yegnasubramanian S, Rettig MB, Elashoff DA, Platz EA, De Marzo AM, et al. CD38 is methylated in prostate cancer and regulates extracellular NAD. Cancer & Metabolism. 6: 13. PMID 30258629 DOI: 10.1186/s40170-018-0186-3  0.64
2018 Langston ME, Pakpahan R, Nevin RL, De Marzo AM, Elliott DJ, Gaydos CA, Isaacs WB, Nelson WG, Sokoll LJ, Zenilman JM, Platz EA, Sutcliffe S. Sustained influence of infections on prostate-specific antigen concentration: An analysis of changes over 10 years of follow-up. The Prostate. 78: 1024-1034. PMID 30133756 DOI: 10.1002/pros.23660  0.64
2018 Wu Y, Yu H, Zheng SL, Feng B, Kapron AL, Na R, Boyle JL, Shah S, Shi Z, Ewing CM, Wiley KE, Luo J, Walsh PC, Carter HB, Helfand BT, ... ... Isaacs WB, et al. Germline mutations in PPFIBP2 are associated with lethal prostate cancer. The Prostate. PMID 30043417 DOI: 10.1002/pros.23697  0.4
2017 Chen H, Ewing CM, Zheng S, Grindedaal EM, Cooney KA, Wiley K, Djurovic S, Andreassen OA, Axcrona K, Mills IG, Xu J, Maehle L, Fosså SD, Isaacs WB. Genetic factors influencing prostate cancer risk in Norwegian men. The Prostate. PMID 29181843 DOI: 10.1002/pros.23453  0.4
2017 Guedes L, Antonarakis ES, Schweizer MT, Mirkheshti N, Almutairi F, Park JC, Glavaris SA, Hicks JL, Eisenberger MA, De Marzo AM, Epstein JI, Isaacs WB, Eshleman JR, Pritchard CC, Lotan TL. MSH2 Loss in Primary Prostate Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28790115 DOI: 10.1158/1078-0432.CCR-17-0955  0.64
2017 Haffner MC, Esopi DM, Chaux A, Gürel M, Ghosh S, Vaghasia AM, Tsai H, Kim K, Castagna N, Lam H, Hicks J, Wyhs N, Biswal Shinohara D, Hurley PJ, Simons BW, ... ... Isaacs WB, et al. AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination. Nature Communications. 8: 142. PMID 28747635 DOI: 10.1038/s41467-017-00084-8  0.64
2017 Milbrandt M, Winter AC, Nevin RL, Pakpahan R, Bradwin G, De Marzo AM, Elliott DJ, Gaydos CA, Isaacs WB, Nelson WG, Rifai N, Sokoll LJ, Zenilman JM, Platz EA, Sutcliffe S. Insight into infection-mediated prostate damage: Contrasting patterns of C-reactive protein and prostate-specific antigen levels during infection. The Prostate. PMID 28703328 DOI: 10.1002/pros.23392  0.64
2017 Guedes L, Almutairi F, Haffner MC, Rajoria G, Liu Z, Klimek S, Zoino R, Yousefi K, Sharma R, De Marzo AM, Netto G, Isaacs WB, Ross AE, Schaeffer EM, Lotan TL. Analytic, Pre-analytic and Clinical Validation of p53 Immunohistochemistry for Detection of TP53 Missense Mutation in Prostate Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28446506 DOI: 10.1158/1078-0432.CCR-17-0257  0.64
2017 Winchester DA, Till C, Goodman PJ, Tangen CM, Santella RM, Johnson-Pais TL, Leach RJ, Xu J, Zheng SL, Thompson IM, Lucia MS, Lippman SM, Parnes HL, Isaacs WB, De Marzo AM, et al. Association between variants in genes involved in the immune response and prostate cancer risk in men randomized to the finasteride arm in the Prostate Cancer Prevention Trial. The Prostate. PMID 28317149 DOI: 10.1002/pros.23346  0.64
2017 Lotan TL, Torres A, Zhang M, Tosoian JJ, Guedes LB, Fedor H, Hicks J, Ewing CM, Isaacs SD, Johng D, De Marzo AM, Isaacs WB. Somatic molecular subtyping of prostate tumors from HOXB13 G84E carriers. Oncotarget. PMID 28186998 DOI: 10.18632/oncotarget.15196  0.64
2016 Na R, Zheng SL, Han M, Yu H, Jiang D, Shah S, Ewing CM, Zhang L, Novakovic K, Petkewicz J, Gulukota K, Helseth DL, Quinn M, Humphries E, Wiley KE, ... ... Isaacs WB, et al. Germline Mutations in ATM and BRCA1/2 Distinguish Risk for Lethal and Indolent Prostate Cancer and are Associated with Early Age at Death. European Urology. PMID 27989354 DOI: 10.1016/j.eururo.2016.11.033  0.64
2016 Kumar B, Khaleghzadegan S, Mears B, Hatano K, Kudrolli TA, Chowdhury WH, Yeater DB, Ewing CM, Luo J, Isaacs WB, Marchionni L, Lupold SE. Identification of miR-30b-3p and miR-30d-5p as direct regulators of Androgen Receptor Signaling in Prostate Cancer by complementary functional microRNA library screening. Oncotarget. PMID 27683042 DOI: 10.18632/oncotarget.12241  0.4
2016 Kulac I, Gumuskaya B, Drake CG, Gonzalez B, Arnold KB, Goodman PJ, Kristal AR, Lucia MS, Thompson IM, Isaacs WB, De Marzo AM, Platz EA. Peripheral zone inflammation is not strongly associated with lower urinary tract symptom incidence and progression in the placebo arm of the prostate cancer prevention trial . The Prostate. PMID 27325488 DOI: 10.1002/pros.23224  0.64
2016 Winchester DA, Gurel B, Till C, Goodman PJ, Tangen CM, Santella RM, Johnson-Pais TL, Leach RJ, Thompson IM, Xu J, Zheng SL, Lucia MS, Lippman SM, Parnes HL, Isaacs WB, et al. Key genes involved in the immune response are generally not associated with intraprostatic inflammation in men without a prostate cancer diagnosis: Results from the prostate cancer prevention trial. The Prostate. PMID 26771888 DOI: 10.1002/pros.23147  1
2015 Sutcliffe S, Nevin RL, Pakpahan R, Elliott DJ, Langston ME, De Marzo AM, Gaydos CA, Isaacs WB, Nelson WG, Sokoll LJ, Walsh PC, Zenilman JM, Cersovsky SB, Platz EA. Infectious Mononucleosis, Other Infections, and Prostate-Specific Antigen Concentration as a Marker of Prostate Involvement During Infection. International Journal of Cancer. Journal International Du Cancer. PMID 26678984 DOI: 10.1002/ijc.29966  1
2015 Lynch HT, Kosoko-Lasaki O, Leslie SW, Rendell M, Shaw T, Snyder C, D'Amico AV, Buxbaum S, Isaacs WB, Loeb S, Moul JW, Powell I. Screening for Familial and Hereditary Prostate Cancer. International Journal of Cancer. Journal International Du Cancer. PMID 26638190 DOI: 10.1002/ijc.29949  1
2015 Hurley PJ, Sundi D, Shinder B, Simons B, Hughes RM, Miller RM, Benzon B, Faraj SF, Netto GJ, Vergara IA, Erho N, Davicioni E, Karnes RJ, Yan G, Ewing CM, ... ... Isaacs WB, et al. Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment and are Differentially Associated with Metastatic Prostate Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26446945 DOI: 10.1158/1078-0432.CCR-15-0256  1
2015 Wang M, Takahashi A, Liu F, Ye D, Ding Q, Qin C, Yin C, Zhang Z, Matsuda K, Kubo M, Na R, Lin X, Jiang H, Ren S, Sun J, ... ... Isaacs WB, et al. Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer. Nature Communications. 6: 8469. PMID 26443449 DOI: 10.1038/ncomms9469  1
2015 Haffner MC, Weier C, Xu M, Vaghasia A, Gürel B, Gümüşkaya B, Esopi DM, Fedor H, Tan HL, Kulac I, Hicks J, Isaacs WB, Lotan TL, Nelson WG, Yegnasubramanian S, et al. Molecular evidence that invasive adenocarcinoma can mimic prostatic intraepithelial neoplasia (PIN) and intraductal carcinoma through retrograde glandular colonization. The Journal of Pathology. PMID 26331372 DOI: 10.1002/path.4628  1
2015 Tsai H, Morais CL, Alshalalfa M, Tan HL, Haddad Z, Hicks JL, Gupta N, Epstein JI, Netto GJ, Isaacs WB, Luo J, Mehra R, Vessella RL, Karnes RJ, Schaeffer E, et al. Cyclin D1 Loss Distinguishes Prostatic Small Cell Carcinoma from Most Prostatic Adenocarcinomas. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26246306 DOI: 10.1158/1078-0432.CCR-15-0744  1
2015 Han Y, Hazelett DJ, Wiklund F, Schumacher FR, Stram DO, Berndt SI, Wang Z, Rand KA, Hoover RN, Machiela MJ, Yeager M, Burdette L, Chung CC, Hutchinson A, Yu K, ... ... Isaacs WB, et al. Integration of Multiethnic Fine-mapping and Genomic Annotation to Prioritize Candidate Functional SNPs at Prostate Cancer Susceptibility Regions. Human Molecular Genetics. PMID 26162851 DOI: 10.1093/hmg/ddv269  1
2015 Beebe-Dimmer JL, Hathcock M, Yee C, Okoth LA, Ewing CM, Isaacs WB, Cooney KA, Thibodeau SN. The HOXB13 G84E Mutation Is Associated with an Increased Risk for Prostate Cancer and Other Malignancies. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 24: 1366-72. PMID 26108461 DOI: 10.1158/1055-9965.EPI-15-0247  1
2015 Winchester DA, Till C, Goodman PJ, Tangen CM, Santella RM, Johnson-Pais TL, Leach RJ, Xu J, Zheng SL, Thompson IM, Lucia MS, Lippmann SM, Parnes HL, Dluzniewski PJ, Isaacs WB, et al. Variation in genes involved in the immune response and prostate cancer risk in the placebo arm of the Prostate Cancer Prevention Trial. The Prostate. PMID 26047319 DOI: 10.1002/pros.23021  1
2015 Helfand BT, Roehl KA, Cooper PR, McGuire BB, Fitzgerald LM, Cancel-Tassin G, Cornu JN, Bauer S, Van Blarigan EL, Chen X, Duggan D, Ostrander EA, Gwo-Shu M, Zhang ZF, Chang SC, ... ... Isaacs WB, et al. Associations of prostate cancer risk variants with disease aggressiveness: results of the NCI-SPORE Genetics Working Group analysis of 18,343 cases. Human Genetics. 134: 439-50. PMID 25715684 DOI: 10.1007/s00439-015-1534-9  1
2015 Dluzniewski PJ, Xu J, Ruczinski I, Isaacs WB, Platz EA. Polymorphisms influencing prostate-specific antigen concentration may bias genome-wide association studies on prostate cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 24: 88-93. PMID 25352524 DOI: 10.1158/1055-9965.EPI-14-0863  1
2015 Loeb S, Peskoe SB, Joshu CE, Huang WY, Hayes RB, Carter HB, Isaacs WB, Platz EA. Do environmental factors modify the genetic risk of prostate cancer? Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 24: 213-20. PMID 25342390 DOI: 10.1158/1055-9965.EPI-14-0786-T  1
2015 Karantanos T, Evans CP, Tombal B, Thompson TC, Montironi R, Isaacs WB. Understanding the mechanisms of androgen deprivation resistance in prostate cancer at the molecular level. European Urology. 67: 470-9. PMID 25306226 DOI: 10.1016/j.eururo.2014.09.049  1
2014 Al Olama AA, Kote-Jarai Z, Berndt SI, Conti DV, Schumacher F, Han Y, Benlloch S, Hazelett DJ, Wang Z, Saunders E, Leongamornlert D, Lindstrom S, Jugurnauth-Little S, Dadaev T, Tymrakiewicz M, ... ... Isaacs WB, et al. A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. Nature Genetics. 46: 1103-9. PMID 25217961 DOI: 10.1038/ng.3094  1
2014 Antonarakis ES, Lu C, Wang H, Luber B, Nakazawa M, Roeser JC, Chen Y, Mohammad TA, Chen Y, Fedor HL, Lotan TL, Zheng Q, De Marzo AM, Isaacs JT, Isaacs WB, et al. AR-V7 and resistance to enzalutamide and abiraterone in prostate cancer. The New England Journal of Medicine. 371: 1028-38. PMID 25184630 DOI: 10.1056/NEJMoa1315815  1
2014 Bhavsar NA, Bream JH, Meeker AK, Drake CG, Peskoe SB, Dabitao D, De Marzo AM, Isaacs WB, Platz EA. A peripheral circulating TH1 cytokine profile is inversely associated with prostate cancer risk in CLUE II. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 23: 2561-7. PMID 25150281 DOI: 10.1158/1055-9965.EPI-14-0010  1
2014 Tubio JM, Li Y, Ju YS, Martincorena I, Cooke SL, Tojo M, Gundem G, Pipinikas CP, Zamora J, Raine K, Menzies A, Roman-Garcia P, Fullam A, Gerstung M, Shlien A, ... ... Isaacs WB, et al. Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes. Science (New York, N.Y.). 345: 1251343. PMID 25082706 DOI: 10.1126/science.1251343  1
2014 Zuhlke KA, Johnson AM, Tomlins SA, Palanisamy N, Carpten JD, Lange EM, Isaacs WB, Cooney KA. Identification of a novel germline SPOP mutation in a family with hereditary prostate cancer. The Prostate. 74: 983-90. PMID 24796539 DOI: 10.1002/pros.22818  1
2014 Lange EM, Johnson AM, Wang Y, Zuhlke KA, Lu Y, Ribado JV, Keele GR, Li J, Duan Q, Li G, Gao Z, Li Y, Xu J, Isaacs WB, Zheng S, et al. Genome-wide association scan for variants associated with early-onset prostate cancer. Plos One. 9: e93436. PMID 24740154 DOI: 10.1371/journal.pone.0093436  1
2014 Tan HL, Sood A, Rahimi HA, Wang W, Gupta N, Hicks J, Mosier S, Gocke CD, Epstein JI, Netto GJ, Liu W, Isaacs WB, De Marzo AM, Lotan TL. Rb loss is characteristic of prostatic small cell neuroendocrine carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 890-903. PMID 24323898 DOI: 10.1158/1078-0432.CCR-13-1982  0.64
2014 Hurwitz LM, Heaphy CM, Joshu CE, Isaacs WB, Konishi Y, De Marzo AM, Isaacs SD, Wiley KE, Platz EA, Meeker AK. Telomere length as a risk factor for hereditary prostate cancer. The Prostate. 74: 359-64. PMID 24285042 DOI: 10.1002/pros.22755  1
2014 Teerlink CC, Thibodeau SN, McDonnell SK, Schaid DJ, Rinckleb A, Maier C, Vogel W, Cancel-Tassin G, Egrot C, Cussenot O, Foulkes WD, Giles GG, Hopper JL, Severi G, Eeles R, ... ... Isaacs WB, et al. Association analysis of 9,560 prostate cancer cases from the International Consortium of Prostate Cancer Genetics confirms the role of reported prostate cancer associated SNPs for familial disease. Human Genetics. 133: 347-56. PMID 24162621 DOI: 10.1007/s00439-013-1384-2  1
2014 Beebe-Dimmer JL, Isaacs WB, Zuhlke KA, Yee C, Walsh PC, Isaacs SD, Johnson AM, Ewing CE, Humphreys EB, Chowdhury WH, Montie JE, Cooney KA. Prevalence of the HOXB13 G84E prostate cancer risk allele in men treated with radical prostatectomy. Bju International. 113: 830-5. PMID 24148311 DOI: 10.1111/bju.12522  1
2013 Sfanos KS, Isaacs WB, De Marzo AM. Infections and inflammation in prostate cancer. American Journal of Clinical and Experimental Urology. 1: 3-11. PMID 25110720  0.96
2013 Haffner MC, Mosbruger T, Esopi DM, Fedor H, Heaphy CM, Walker DA, Adejola N, Gürel M, Hicks J, Meeker AK, Halushka MK, Simons JW, Isaacs WB, De Marzo AM, Nelson WG, et al. Tracking the clonal origin of lethal prostate cancer. The Journal of Clinical Investigation. 123: 4918-22. PMID 24135135 DOI: 10.1172/JCI70354  1
2013 Weier C, Haffner MC, Mosbruger T, Esopi DM, Hicks J, Zheng Q, Fedor H, Isaacs WB, De Marzo AM, Nelson WG, Yegnasubramanian S. Nucleotide resolution analysis of TMPRSS2 and ERG rearrangements in prostate cancer. The Journal of Pathology. 230: 174-83. PMID 23447416 DOI: 10.1002/path.4186  0.64
2013 Chen Z, Greenwood C, Isaacs WB, Foulkes WD, Sun J, Zheng SL, Condreay LD, Xu J. The G84E mutation of HOXB13 is associated with increased risk for prostate cancer: results from the REDUCE trial. Carcinogenesis. 34: 1260-4. PMID 23393222 DOI: 10.1093/carcin/bgt055  1
2013 Aryee MJ, Liu W, Engelmann JC, Nuhn P, Gurel M, Haffner MC, Esopi D, Irizarry RA, Getzenberg RH, Nelson WG, Luo J, Xu J, Isaacs WB, Bova GS, Yegnasubramanian S. DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases. Science Translational Medicine. 5: 169ra10. PMID 23345608 DOI: 10.1126/scitranslmed.3005211  1
2012 Zuhlke KA, Johnson AM, Okoth LA, Stoffel EM, Robbins CM, Tembe WA, Salinas CA, Zheng SL, Xu J, Carpten JD, Lange EM, Isaacs WB, Cooney KA. Identification of a novel NBN truncating mutation in a family with hereditary prostate cancer. Familial Cancer. 11: 595-600. PMID 22864661 DOI: 10.1007/s10689-012-9555-1  1
2012 Dluzniewski PJ, Wang MH, Zheng SL, De Marzo AM, Drake CG, Fedor HL, Partin AW, Han M, Fallin MD, Xu J, Isaacs WB, Platz EA. Variation in IL10 and other genes involved in the immune response and in oxidation and prostate cancer recurrence. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 21: 1774-82. PMID 22859398 DOI: 10.1158/1055-9965.EPI-12-0458  1
2012 Bailey-Wilson JE, Childs EJ, Cropp CD, Schaid DJ, Xu J, Camp NJ, Cannon-Albright LA, Farnham JM, George A, Powell I, Carpten JD, Giles GG, Hopper JL, Severi G, English DR, ... ... Isaacs WB, et al. Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families. Bmc Medical Genetics. 13: 46. PMID 22712434 DOI: 10.1186/1471-2350-13-46  1
2012 Hu R, Lu C, Mostaghel EA, Yegnasubramanian S, Gurel M, Tannahill C, Edwards J, Isaacs WB, Nelson PS, Bluemn E, Plymate SR, Luo J. Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer. Cancer Research. 72: 3457-62. PMID 22710436 DOI: 10.1158/0008-5472.CAN-11-3892  1
2012 Kader AK, Sun J, Reck BH, Newcombe PJ, Kim ST, Hsu FC, D'Agostino RB, Tao S, Zhang Z, Turner AR, Platek GT, Spraggs CF, Whittaker JC, Lane BR, Isaacs WB, et al. Potential impact of adding genetic markers to clinical parameters in predicting prostate biopsy outcomes in men following an initial negative biopsy: findings from the REDUCE trial. European Urology. 62: 953-61. PMID 22652152 DOI: 10.1016/j.eururo.2012.05.006  1
2012 Hager MH, Morley S, Bielenberg DR, Gao S, Morello M, Holcomb IN, Liu W, Mouneimne G, Demichelis F, Kim J, Solomon KR, Adam RM, Isaacs WB, Higgs HN, Vessella RL, et al. DIAPH3 governs the cellular transition to the amoeboid tumour phenotype. Embo Molecular Medicine. 4: 743-60. PMID 22593025 DOI: 10.1002/emmm.201200242  1
2012 Ewing CM, Ray AM, Lange EM, Zuhlke KA, Robbins CM, Tembe WD, Wiley KE, Isaacs SD, Johng D, Wang Y, Bizon C, Yan G, Gielzak M, Partin AW, Shanmugam V, ... ... Isaacs WB, et al. Germline mutations in HOXB13 and prostate-cancer risk. The New England Journal of Medicine. 366: 141-9. PMID 22236224 DOI: 10.1056/NEJMoa1110000  1
2012 Jin G, Lu L, Cooney KA, Ray AM, Zuhlke KA, Lange EM, Cannon-Albright LA, Camp NJ, Teerlink CC, Fitzgerald LM, Stanford JL, Wiley KE, Isaacs SD, Walsh PC, Foulkes WD, ... ... Isaacs WB, et al. Validation of prostate cancer risk-related loci identified from genome-wide association studies using family-based association analysis: evidence from the International Consortium for Prostate Cancer Genetics (ICPCG). Human Genetics. 131: 1095-103. PMID 22198737 DOI: 10.1007/s00439-011-1136-0  1
2012 Lu L, Cancel-Tassin G, Valeri A, Cussenot O, Lange EM, Cooney KA, Farnham JM, Camp NJ, Cannon-Albright LA, Tammela TL, Schleutker J, Hoegel J, Herkommer K, Maier C, Vogel W, ... ... Isaacs WB, et al. Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG. The Prostate. 72: 410-26. PMID 21748754 DOI: 10.1002/pros.21443  1
2011 Lotan TL, Gurel B, Sutcliffe S, Esopi D, Liu W, Xu J, Hicks JL, Park BH, Humphreys E, Partin AW, Han M, Netto GJ, Isaacs WB, De Marzo AM. PTEN protein loss by immunostaining: analytic validation and prognostic indicator for a high risk surgical cohort of prostate cancer patients. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 6563-73. PMID 21878536 DOI: 10.1158/1078-0432.CCR-11-1244  1
2011 Jin G, Sun J, Isaacs SD, Wiley KE, Kim ST, Chu LW, Zhang Z, Zhao H, Zheng SL, Isaacs WB, Xu J. Human polymorphisms at long non-coding RNAs (lncRNAs) and association with prostate cancer risk. Carcinogenesis. 32: 1655-9. PMID 21856995 DOI: 10.1093/carcin/bgr187  1
2011 Lin DW, FitzGerald LM, Fu R, Kwon EM, Zheng SL, Kolb S, Wiklund F, Stattin P, Isaacs WB, Xu J, Ostrander EA, Feng Z, Grönberg H, Stanford JL. Genetic variants in the LEPR, CRY1, RNASEL, IL4, and ARVCF genes are prognostic markers of prostate cancer-specific mortality. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 20: 1928-36. PMID 21846818 DOI: 10.1158/1055-9965.EPI-11-0236  1
2011 Toubaji A, Albadine R, Meeker AK, Isaacs WB, Lotan T, Haffner MC, Chaux A, Epstein JI, Han M, Walsh PC, Partin AW, De Marzo AM, Platz EA, Netto GJ. Increased gene copy number of ERG on chromosome 21 but not TMPRSS2-ERG fusion predicts outcome in prostatic adenocarcinomas. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 24: 1511-20. PMID 21743434 DOI: 10.1038/modpathol.2011.111  1
2011 Schumacher FR, Berndt SI, Siddiq A, Jacobs KB, Wang Z, Lindstrom S, Stevens VL, Chen C, Mondul AM, Travis RC, Stram DO, Eeles RA, Easton DF, Giles G, Hopper JL, ... ... Isaacs WB, et al. Genome-wide association study identifies new prostate cancer susceptibility loci. Human Molecular Genetics. 20: 3867-75. PMID 21743057 DOI: 10.1093/hmg/ddr295  1
2011 Haiman CA, Chen GK, Blot WJ, Strom SS, Berndt SI, Kittles RA, Rybicki BA, Isaacs WB, Ingles SA, Stanford JL, Diver WR, Witte JS, Chanock SJ, Kolb S, Signorello LB, et al. Characterizing genetic risk at known prostate cancer susceptibility loci in African Americans. Plos Genetics. 7: e1001387. PMID 21637779 DOI: 10.1371/journal.pgen.1001387  1
2011 Haiman CA, Chen GK, Blot WJ, Strom SS, Berndt SI, Kittles RA, Rybicki BA, Isaacs WB, Ingles SA, Stanford JL, Diver WR, Witte JS, Hsing AW, Nemesure B, Rebbeck TR, et al. Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. Nature Genetics. 43: 570-3. PMID 21602798 DOI: 10.1038/ng.839  1
2011 Catalona WJ, Bailey-Wilson JE, Camp NJ, Chanock SJ, Cooney KA, Easton DF, Eeles RA, FitzGerald LM, Freedman ML, Gudmundsson J, Kittles RA, Margulies EH, McGuire BB, Ostrander EA, Rebbeck TR, ... ... Isaacs WB, et al. National Cancer Institute Prostate Cancer Genetics Workshop. Cancer Research. 71: 3442-6. PMID 21558387 DOI: 10.1158/0008-5472.CAN-11-0314  1
2011 Chung CC, Ciampa J, Yeager M, Jacobs KB, Berndt SI, Hayes RB, Gonzalez-Bosquet J, Kraft P, Wacholder S, Orr N, Yu K, Hutchinson A, Boland J, Chen Q, Feigelson HS, ... ... Isaacs WB, et al. Fine mapping of a region of chromosome 11q13 reveals multiple independent loci associated with risk of prostate cancer. Human Molecular Genetics. 20: 2869-78. PMID 21531787 DOI: 10.1093/hmg/ddr189  1
2011 Wilson BA, Wang H, Nacev BA, Mease RC, Liu JO, Pomper MG, Isaacs WB. High-throughput screen identifies novel inhibitors of cancer biomarker α-methylacyl coenzyme A racemase (AMACR/P504S). Molecular Cancer Therapeutics. 10: 825-38. PMID 21441411 DOI: 10.1158/1535-7163.MCT-10-0902  1
2011 Fujita K, Ewing CM, Isaacs WB, Pavlovich CP. Immunomodulatory IL-18 binding protein is produced by prostate cancer cells and its levels in urine and serum correlate with tumor status. International Journal of Cancer. 129: 424-32. PMID 20878981 DOI: 10.1002/ijc.25705  0.4
2010 Aloia AL, Sfanos KS, Isaacs WB, Zheng Q, Maldarelli F, De Marzo AM, Rein A. XMRV: a new virus in prostate cancer? Cancer Research. 70: 10028-33. PMID 20966126 DOI: 10.1158/0008-5472.CAN-10-2837  0.96
2010 Haffner MC, Aryee MJ, Toubaji A, Esopi DM, Albadine R, Gurel B, Isaacs WB, Bova GS, Liu W, Xu J, Meeker AK, Netto G, De Marzo AM, Nelson WG, Yegnasubramanian S. Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements. Nature Genetics. 42: 668-75. PMID 20601956 DOI: 10.1038/ng.613  1
2010 Elliott KS, Zeggini E, McCarthy MI, Gudmundsson J, Sulem P, Stacey SN, Thorlacius S, Amundadottir L, Grönberg H, Xu J, Gaborieau V, Eeles RA, Neal DE, Donovan JL, Hamdy FC, ... ... Isaacs WB, et al. Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies. Plos One. 5: e10858. PMID 20526366 DOI: 10.1371/journal.pone.0010858  1
2010 Prokunina-Olsson L, Fu YP, Tang W, Jacobs KB, Hayes RB, Kraft P, Berndt SI, Wacholder S, Yu K, Hutchinson A, Spencer Feigelson H, Thun MJ, Diver WR, Albanes D, Virtamo J, ... ... Isaacs WB, et al. Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p15.2. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 19: 1349-55. PMID 20406958 DOI: 10.1158/1055-9965.EPI-09-1181  1
2010 Christensen GB, Baffoe-Bonnie AB, George A, Powell I, Bailey-Wilson JE, Carpten JD, Giles GG, Hopper JL, Severi G, English DR, Foulkes WD, Maehle L, Moller P, Eeles R, Easton D, ... ... Isaacs WB, et al. Genome-wide linkage analysis of 1,233 prostate cancer pedigrees from the International Consortium for Prostate Cancer Genetics using novel sumLINK and sumLOD analyses. The Prostate. 70: 735-44. PMID 20333727 DOI: 10.1002/pros.21106  1
2010 Xu J, Zheng SL, Isaacs SD, Wiley KE, Wiklund F, Sun J, Kader AK, Li G, Purcell LD, Kim ST, Hsu FC, Stattin P, Hugosson J, Adolfsson J, Walsh PC, ... ... Isaacs WB, et al. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. 107: 2136-40. PMID 20080650 DOI: 10.1073/pnas.0914061107  1
2010 Lubahn J, Berndt SI, Jin CH, Klim A, Luly J, Wu WS, Isaacs S, Wiley K, Isaacs WB, Suarez BK, Hayes RB, Kibel AS. Association of CASP8 D302H polymorphism with reduced risk of aggressive prostate carcinoma. The Prostate. 70: 646-53. PMID 20033885 DOI: 10.1002/pros.21098  1
2010 Fujita K, Ewing CM, Getzenberg RH, Parsons JK, Isaacs WB, Pavlovich CP. Monocyte chemotactic protein-1 (MCP-1/CCL2) is associated with prostatic growth dysregulation and benign prostatic hyperplasia. The Prostate. 70: 473-81. PMID 19902472 DOI: 10.1002/pros.21081  0.4
2010 Zheng SL, Hsing AW, Sun J, Chu LW, Yu K, Li G, Gao Z, Kim ST, Isaacs WB, Shen MC, Gao YT, Hoover RN, Xu J. Association of 17 prostate cancer susceptibility loci with prostate cancer risk in Chinese men. The Prostate. 70: 425-32. PMID 19866473 DOI: 10.1002/pros.21076  1
2009 Albadine R, Latour M, Toubaji A, Haffner M, Isaacs WB, A Platz E, Meeker AK, Demarzo AM, Epstein JI, Netto GJ. TMPRSS2-ERG gene fusion status in minute (minimal) prostatic adenocarcinoma. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 22: 1415-22. PMID 19734849 DOI: 10.1038/modpathol.2009.121  1
2009 Sfanos KS, Bruno TC, Meeker AK, De Marzo AM, Isaacs WB, Drake CG. Human prostate-infiltrating CD8+ T lymphocytes are oligoclonal and PD-1+. The Prostate. 69: 1694-703. PMID 19670224 DOI: 10.1002/pros.21020  1
2009 Loeb S, Helfand BT, Kan D, Isaacs WB, Catalona WJ. Does diabetes mellitus modify the association between 17q12 risk variant and prostate cancer aggressiveness? Bju International. 104: 1200-3. PMID 19627283 DOI: 10.1111/j.1464-410X.2009.08656.x  1
2009 Lu L, Sun J, Isaacs SD, Wiley KE, Smith S, Pruett K, Zhu Y, Zhang Z, Wiklund F, Grönberg H, Walsh PC, Chang BL, Zheng SL, Isaacs WB, Xu J. Fine-mapping and family-based association analyses of prostate cancer risk variants at Xp11. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 18: 2132-6. PMID 19549809 DOI: 10.1158/1055-9965.EPI-08-1221  1
2009 Xu J, Kibel AS, Hu JJ, Turner AR, Pruett K, Zheng SL, Sun J, Isaacs SD, Wiley KE, Kim ST, Hsu FC, Wu W, Torti FM, Walsh PC, Chang BL, ... Isaacs WB, et al. Prostate cancer risk associated loci in African Americans. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 18: 2145-9. PMID 19549807 DOI: 10.1158/1055-9965.EPI-09-0091  1
2009 Fujita K, Pavlovich CP, Netto GJ, Konishi Y, Isaacs WB, Ali S, De Marzo A, Meeker AK. Specific detection of prostate cancer cells in urine by multiplex immunofluorescence cytology. Human Pathology. 40: 924-33. PMID 19368959 DOI: 10.1016/j.humpath.2009.01.004  1
2009 Liu W, Laitinen S, Khan S, Vihinen M, Kowalski J, Yu G, Chen L, Ewing CM, Eisenberger MA, Carducci MA, Nelson WG, Yegnasubramanian S, Luo J, Wang Y, Xu J, ... Isaacs WB, et al. Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer. Nature Medicine. 15: 559-65. PMID 19363497 DOI: 10.1038/nm.1944  0.48
2009 Hsu FC, Sun J, Wiklund F, Isaacs SD, Wiley KE, Purcell LD, Gao Z, Stattin P, Zhu Y, Kim ST, Zhang Z, Liu W, Chang BL, Walsh PC, Duggan D, ... ... Isaacs WB, et al. A novel prostate cancer susceptibility locus at 19q13. Cancer Research. 69: 2720-3. PMID 19318570 DOI: 10.1158/0008-5472.CAN-08-3347  1
2009 Wang MH, Helzlsouer KJ, Smith MW, Hoffman-Bolton JA, Clipp SL, Grinberg V, De Marzo AM, Isaacs WB, Drake CG, Shugart YY, Platz EA. Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II Prostate. 69: 874-885. PMID 19267370 DOI: 10.1002/pros.20933  1
2009 Sfanos KS, Wilson BA, De Marzo AM, Isaacs WB. Acute inflammatory proteins constitute the organic matrix of prostatic corpora amylacea and calculi in men with prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. 106: 3443-8. PMID 19202053 DOI: 10.1073/pnas.0810473106  0.96
2009 Chang BL, Cramer SD, Wiklund F, Isaacs SD, Stevens VL, Sun J, Smith S, Pruett K, Romero LM, Wiley KE, Kim ST, Zhu Y, Zhang Z, Hsu FC, Turner AR, ... ... Isaacs WB, et al. Fine mapping association study and functional analysis implicate a SNP in MSMB at 10q11 as a causal variant for prostate cancer risk. Human Molecular Genetics. 18: 1368-75. PMID 19153072 DOI: 10.1093/hmg/ddp035  1
2009 Parsons JK, Saria EA, Nakayama M, Vessella RL, Sawyers CL, Isaacs WB, Faith DA, Bova GS, Samathanam CA, Mitchell R, De Marzo AM. Comprehensive mutational analysis and mRNA isoform quantification of TP63 in normal and neoplastic human prostate cells. The Prostate. 69: 559-69. PMID 19142959 DOI: 10.1002/pros.20904  0.64
2008 Sfanos KS, Isaacs WB. An evaluation of PCR primer sets used for detection of Propionibacterium acnes in prostate tissue samples. The Prostate. 68: 1492-5. PMID 18651578 DOI: 10.1002/pros.20820  0.96
2008 Sfanos KS, Bruno TC, Maris CH, Xu L, Thoburn CJ, DeMarzo AM, Meeker AK, Isaacs WB, Drake CG. Phenotypic analysis of prostate-infiltrating lymphocytes reveals TH17 and Treg skewing. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 3254-61. PMID 18519750 DOI: 10.1158/1078-0432.CCR-07-5164  1
2008 Sfanos KS, Sauvageot J, Fedor HL, Dick JD, De Marzo AM, Isaacs WB. A molecular analysis of prokaryotic and viral DNA sequences in prostate tissue from patients with prostate cancer indicates the presence of multiple and diverse microorganisms. The Prostate. 68: 306-20. PMID 18163428 DOI: 10.1002/pros.20680  0.96
2007 Carnell AJ, Hale I, Denis S, Wanders RJ, Isaacs WB, Wilson BA, Ferdinandusse S. Design, synthesis, and in vitro testing of alpha-methylacyl-CoA racemase inhibitors. Journal of Medicinal Chemistry. 50: 2700-7. PMID 17477519 DOI: 10.1021/jm0702377  1
2005 Zha S, Isaacs WB. A nonclassic CCAAT enhancer element binding protein binding site contributes to alpha-methylacyl-CoA racemase expression in prostate cancer. Molecular Cancer Research : McR. 3: 110-8. PMID 15755877 DOI: 10.1158/1541-7786.MCR-04-0178  1
2005 Zha S, Ferdinandusse S, Hicks JL, Denis S, Dunn TA, Wanders RJ, Luo J, De Marzo AM, Isaacs WB. Peroxisomal branched chain fatty acid beta-oxidation pathway is upregulated in prostate cancer. The Prostate. 63: 316-23. PMID 15599942 DOI: 10.1002/pros.20177  1
2004 Zha S, Yegnasubramanian V, Nelson WG, Isaacs WB, De Marzo AM. Cyclooxygenases in cancer: progress and perspective. Cancer Letters. 215: 1-20. PMID 15374627 DOI: 10.1016/j.canlet.2004.06.014  1
2004 Rogers CG, Yan G, Zha S, Gonzalgo ML, Isaacs WB, Luo J, De Marzo AM, Nelson WG, Pavlovich CP. Prostate cancer detection on urinalysis for alpha methylacyl coenzyme a racemase protein. The Journal of Urology. 172: 1501-3. PMID 15371879  1
2004 Chesire DR, Dunn TA, Ewing CM, Luo J, Isaacs WB. Identification of aryl hydrocarbon receptor as a putative Wnt/beta-catenin pathway target gene in prostate cancer cells. Cancer Research. 64: 2523-33. PMID 15059908 DOI: 10.1158/0008-5472.CAN-03-3309  1
2003 Chesire DR, Isaacs WB. Beta-catenin signaling in prostate cancer: an early perspective. Endocrine-Related Cancer. 10: 537-60. PMID 14713266  1
2003 Zha S, Ferdinandusse S, Denis S, Wanders RJ, Ewing CM, Luo J, De Marzo AM, Isaacs WB. Alpha-methylacyl-CoA racemase as an androgen-independent growth modifier in prostate cancer. Cancer Research. 63: 7365-76. PMID 14612535  1
2003 De Marzo AM, Meeker AK, Zha S, Luo J, Nakayama M, Platz EA, Isaacs WB, Nelson WG. Human prostate cancer precursors and pathobiology. Urology. 62: 55-62. PMID 14607218 DOI: 10.1016/j.urology.2003.09.053  1
2002 Chesire DR, Isaacs WB. Ligand-dependent inhibition of beta-catenin/TCF signaling by androgen receptor. Oncogene. 21: 8453-69. PMID 12466965 DOI: 10.1038/sj.onc.1206049  1
2002 Chesire DR, Ewing CM, Gage WR, Isaacs WB. In vitro evidence for complex modes of nuclear beta-catenin signaling during prostate growth and tumorigenesis. Oncogene. 21: 2679-94. PMID 11965541 DOI: 10.1038/sj.onc.1205352  1
2002 Luo J, Zha S, Gage WR, Dunn TA, Hicks JL, Bennett CJ, Ewing CM, Platz EA, Ferdinandusse S, Wanders RJ, Trent JM, Isaacs WB, De Marzo AM. Alpha-methylacyl-CoA racemase: a new molecular marker for prostate cancer. Cancer Research. 62: 2220-6. PMID 11956072  1
2002 Takaha N, Hawkins AL, Griffin CA, Isaacs WB, Coffey DS. High mobility group protein I(Y): a candidate architectural protein for chromosomal rearrangements in prostate cancer cells. Cancer Research. 62: 647-51. PMID 11830513  1
2001 Zha S, Gage WR, Sauvageot J, Saria EA, Putzi MJ, Ewing CM, Faith DA, Nelson WG, De Marzo AM, Isaacs WB. Cyclooxygenase-2 is up-regulated in proliferative inflammatory atrophy of the prostate, but not in prostate carcinoma. Cancer Research. 61: 8617-23. PMID 11751373  1
2000 Chesire DR, Ewing CM, Sauvageot J, Bova GS, Isaacs WB. Detection and analysis of beta-catenin mutations in prostate cancer. The Prostate. 45: 323-34. PMID 11102958 DOI: 10.1002/1097-0045(20001201)45:4<323::AID-PROS7>3.0.CO;2-W  1
1994 Rinker-Schaeffer CW, Partin AW, Isaacs WB, Coffey DS, Isaacs JT. Molecular and cellular changes associated with the acquisition of metastatic ability by prostatic cancer cells Prostate. 25: 249-265. PMID 7971516 DOI: 10.1002/pros.2990250505  1
1992 Pienta KJ, Murphy BC, Isaacs WB, Isaacs JT, Coffey DS. Effect of pentosan, a novel cancer chemotherapeutic agent, on prostate cancer cell growth and motility Prostate. 20: 233-241. PMID 1374181 DOI: 10.1002/pros.2990200308  1
1991 Pienta KJ, Isaacs WB, Vindivich D, Coffey DS. The effects of basic fibroblast growth factor and suramin on cell motility and growth of rat prostate cancer cells Journal of Urology. 145: 199-202. PMID 1984091  1
1990 Isaacs WB, Isaacs JT, Kyprianou N, Burgers JK, Alexander RB, Partin AW, Mohler JL, Marshall FF, Coffey DS. New approaches to the evaluation of the metastatic ability of renal cancer and new approaches to chemotherapy European Urology. 18: 33-35. PMID 2226604  1
1987 Mohler JL, Partin AW, Isaacs WB, Coffey DS. Time lapse videomicroscopic identification of Dunning R-3327 adenocarcinoma and normal rat prostate cells Journal of Urology. 137: 544-547. PMID 3820394  1
1984 Isaacs WB, Coffey DS. The predominant protein of canine seminal plasma is an enzyme Journal of Biological Chemistry. 259: 11520-11526. PMID 6381500  1
1981 Isaacs JT, Barrack ER, Isaacs WB, Coffey DS. The relationship of cellular structure and function: the matrix system Progress in Clinical and Biological Research. 75: 1-24. PMID 7339623  1
1980 Isaacs JT, Isaacs WB, Wheaton LG, Coffey DS. Differential effects of estrogen treatment of canine seminal plasma components Investigative Urology. 17: 495-498. PMID 6154670  1
1979 Isaacs JT, Isaacs WB, Coffey DS. Models for Development of Nonreceptor Methods for Distinguishing Androgen-sensitive and -insensitive Prostatic Tumors Cancer Research. 39: 2652-2659. PMID 445468  1
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