Shan Zha, Ph.D. - Publications

Affiliations: 
1998-2004 Pharmacology and Molecular Sciences Johns Hopkins University, Baltimore, MD 
 2004-2009 Molecular Genetics Harvard - Boston Children's Hospital 
 2009- Institute for Cancer Genetics Columbia University College of Physicians and Surgeons, New York, NY, United States 
Area:
DNA repair, Oncology, Molecular Biology, Pharmacology

43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Jiang W, Estes VM, Wang XS, Shao Z, Lee BJ, Lin X, Crowe JL, Zha S. Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination. Journal of Immunology (Baltimore, Md. : 1950). PMID 31101667 DOI: 10.4049/jimmunol.1801657  0.52
2019 Liu X, Wang XS, Lee BJ, Wu-Baer FK, Lin X, Shao Z, Estes VM, Gautier J, Baer R, Zha S. CtIP is essential for early B cell proliferation and development in mice. The Journal of Experimental Medicine. PMID 31097467 DOI: 10.1084/jem.20181139  0.6
2018 Menolfi D, Jiang W, Lee BJ, Moiseeva T, Shao Z, Estes V, Frattini MG, Bakkenist CJ, Zha S. Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA. Nature Communications. 9: 5351. PMID 30559436 DOI: 10.1038/s41467-018-07798-3  0.52
2018 Billing D, Horiguchi M, Wu-Baer F, Taglialatela A, Leuzzi G, Nanez SA, Jiang W, Zha S, Szabolcs M, Lin CS, Ciccia A, Baer R. The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection. Molecular Cell. PMID 30244837 DOI: 10.1016/j.molcel.2018.08.016  0.52
2018 Crowe JL, Shao Z, Wang XS, Wei PC, Jiang W, Lee BJ, Estes VM, Alt FW, Zha S. Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. PMID 30072430 DOI: 10.1073/pnas.1808490115  1
2018 Hung PJ, Johnson B, Chen BR, Byrum AK, Bredemeyer AL, Yewdell WT, Johnson TE, Lee BJ, Deivasigamani S, Hindi I, Amatya P, Gross ML, Paull TT, Pisapia DJ, Chaudhuri J, ... ... Zha S, et al. MRI Is a DNA Damage Response Adaptor during Classical Non-homologous End Joining. Molecular Cell. PMID 30017584 DOI: 10.1016/j.molcel.2018.06.018  0.32
2017 Liu X, Shao Z, Jiang W, Lee BJ, Zha S. PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice. Nature Communications. 8: 13816. PMID 28051062 DOI: 10.1038/ncomms13816  0.6
2016 Zhou Y, Lee JH, Jiang W, Crowe JL, Zha S, Paull TT. Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM. Molecular Cell. PMID 27939942 DOI: 10.1016/j.molcel.2016.11.004  0.52
2016 Yamamoto K, Wang J, Sprinzen L, Xu J, Haddock CJ, Li C, Lee BJ, Loredan DG, Jiang W, Vindigni A, Wang D, Rabadan R, Zha S. Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors. Elife. 5. PMID 27304073 DOI: 10.7554/eLife.14709  1
2016 Li T, Liu X, Jiang L, Manfredi J, Zha S, Gu W. Loss of p53-mediated cell-cycle arrest, senescence and apoptosis promotes genomic instability and premature aging. Oncotarget. PMID 26943586 DOI: 10.18632/oncotarget.7864  1
2015 Pinkney KA, Jiang W, Lee BJ, Loredan DG, Li C, Bhagat G, Zha S. Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas. Journal of Hematology & Oncology. 8: 94. PMID 26219558 DOI: 10.1186/s13045-015-0191-8  1
2015 Jiang W, Crowe JL, Liu X, Nakajima S, Wang Y, Li C, Lee BJ, Dubois RL, Liu C, Yu X, Lan L, Zha S. Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining. Molecular Cell. 58: 172-85. PMID 25818648 DOI: 10.1016/j.molcel.2015.02.024  1
2015 Jiang W, Lee BJ, Li C, Dubois RL, Gostissa M, Alt FW, Zha S. Aberrant TCRδ rearrangement underlies the T-cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency. Blood. 125: 2665-8. PMID 25721125 DOI: 10.1182/blood-2015-01-622621  1
2015 Yamamoto K, Lee BJ, Li C, Dubois RL, Hobeika E, Bhagat G, Zha S. Early B-cell-specific inactivation of ATM synergizes with ectopic CyclinD1 expression to promote pre-germinal center B-cell lymphomas in mice. Leukemia. 29: 1414-24. PMID 25676421 DOI: 10.1038/leu.2015.41  0.52
2015 Xing M, Yang M, Huo W, Feng F, Wei L, Jiang W, Ning S, Yan Z, Li W, Wang Q, Hou M, Dong C, Guo R, Gao G, Ji J, ... Zha S, et al. Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway. Nature Communications. 6: 6233. PMID 25670504 DOI: 10.1038/ncomms7233  0.52
2014 Avagyan S, Churchill M, Yamamoto K, Crowe JL, Li C, Lee BJ, Zheng T, Mukherjee S, Zha S. Hematopoietic stem cell dysfunction underlies the progressive lymphocytopenia in XLF/Cernunnos deficiency. Blood. 124: 1622-5. PMID 25075129 DOI: 10.1182/blood-2014-05-574863  1
2014 Moding EJ, Lee CL, Castle KD, Oh P, Mao L, Zha S, Min HD, Ma Y, Das S, Kirsch DG. Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium. The Journal of Clinical Investigation. 124: 3325-38. PMID 25036710 DOI: 10.1172/JCI73932  1
2013 Rass E, Chandramouly G, Zha S, Alt FW, Xie A. Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells. The Journal of Biological Chemistry. 288: 7086-95. PMID 23355489 DOI: 10.1074/jbc.M112.445825  1
2013 Oksenych V, Kumar V, Liu X, Guo C, Schwer B, Zha S, Alt FW. Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining. Proceedings of the National Academy of Sciences of the United States of America. 110: 2234-9. PMID 23345432 DOI: 10.1073/pnas.1222573110  1
2012 Yamamoto K, Wang Y, Jiang W, Liu X, Dubois RL, Lin CS, Ludwig T, Bakkenist CJ, Zha S. Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice. The Journal of Cell Biology. 198: 305-13. PMID 22869596 DOI: 10.1083/jcb.201204098  1
2012 Liu X, Jiang W, Dubois RL, Yamamoto K, Wolner Z, Zha S. Overlapping functions between XLF repair protein and 53BP1 DNA damage response factor in end joining and lymphocyte development. Proceedings of the National Academy of Sciences of the United States of America. 109: 3903-8. PMID 22355127 DOI: 10.1073/pnas.1120160109  1
2012 Boboila C, Oksenych V, Gostissa M, Wang JH, Zha S, Zhang Y, Chai H, Lee CS, Jankovic M, Saez LM, Nussenzweig MC, McKinnon PJ, Alt FW, Schwer B. Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1). Proceedings of the National Academy of Sciences of the United States of America. 109: 2473-8. PMID 22308491 DOI: 10.1073/pnas.1121470109  1
2011 Gutierrez A, Kentsis A, Sanda T, Holmfeldt L, Chen SC, Zhang J, Protopopov A, Chin L, Dahlberg SE, Neuberg DS, Silverman LB, Winter SS, Hunger SP, Sallan SE, Zha S, et al. The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. Blood. 118: 4169-73. PMID 21878675 DOI: 10.1182/blood-2010-11-318873  1
2011 Liu X, Zha S. ATMIN: a new tumor suppressor in developing B cells. Cancer Cell. 19: 569-70. PMID 21575856 DOI: 10.1016/j.ccr.2011.05.002  0.6
2011 Zha S, Jiang W, Fujiwara Y, Patel H, Goff PH, Brush JW, Dubois RL, Alt FW. Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions. Proceedings of the National Academy of Sciences of the United States of America. 108: 2028-33. PMID 21245310 DOI: 10.1073/pnas.1019293108  1
2011 Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW. ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks. Nature. 469: 250-4. PMID 21160472 DOI: 10.1038/nature09604  1
2010 Zha S, Bassing CH, Sanda T, Brush JW, Patel H, Goff PH, Murphy MM, Tepsuporn S, Gatti RA, Look AT, Alt FW. ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification. The Journal of Experimental Medicine. 207: 1369-80. PMID 20566716 DOI: 10.1084/jem.20100285  1
2010 Rucci F, Notarangelo LD, Fazeli A, Patrizi L, Hickernell T, Paganini T, Coakley KM, Detre C, Keszei M, Walter JE, Feldman L, Cheng HL, Poliani PL, Wang JH, Balter BB, ... ... Zha S, et al. Homozygous DNA ligase IV R278H mutation in mice leads to leaky SCID and represents a model for human LIG4 syndrome. Proceedings of the National Academy of Sciences of the United States of America. 107: 3024-9. PMID 20133615 DOI: 10.1073/pnas.0914865107  1
2009 Zha S, Boboila C, Alt FW. Mre11: roles in DNA repair beyond homologous recombination. Nature Structural & Molecular Biology. 16: 798-800. PMID 19654615 DOI: 10.1038/nsmb0809-798  1
2009 Callén E, Jankovic M, Wong N, Zha S, Chen HT, Difilippantonio S, Di Virgilio M, Heidkamp G, Alt FW, Nussenzweig A, Nussenzweig M. Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Molecular Cell. 34: 285-97. PMID 19450527 DOI: 10.1016/j.molcel.2009.04.025  1
2009 Derudder E, Cadera EJ, Vahl JC, Wang J, Fox CJ, Zha S, van Loo G, Pasparakis M, Schlissel MS, Schmidt-Supprian M, Rajewsky K. Development of immunoglobulin λ-chain-positive B cells, but not editing of immunoglobulin κ-chain, depends on NF-κB signals Nature Immunology. 10: 647-654. PMID 19412180 DOI: 10.1038/ni.1732  1
2008 Li G, Alt FW, Cheng HL, Brush JW, Goff PH, Murphy MM, Franco S, Zhang Y, Zha S. Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Molecular Cell. 31: 631-40. PMID 18775323 DOI: 10.1016/j.molcel.2008.07.017  1
2008 Zha S, Sekiguchi J, Brush JW, Bassing CH, Alt FW. Complementary functions of ATM and H2AX in development and suppression of genomic instability. Proceedings of the National Academy of Sciences of the United States of America. 105: 9302-6. PMID 18599436 DOI: 10.1073/pnas.0803520105  1
2007 Zha S, Alt FW, Cheng HL, Brush JW, Li G. Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 4518-23. PMID 17360556 DOI: 10.1073/pnas.0611734104  1
2006 Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, et al. H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Molecular Cell. 21: 201-14. PMID 16427010 DOI: 10.1016/j.molcel.2006.01.005  1
2005 Zha S, Isaacs WB. A nonclassic CCAAT enhancer element binding protein binding site contributes to alpha-methylacyl-CoA racemase expression in prostate cancer. Molecular Cancer Research : McR. 3: 110-8. PMID 15755877 DOI: 10.1158/1541-7786.MCR-04-0178  0.32
2005 Zha S, Ferdinandusse S, Hicks JL, Denis S, Dunn TA, Wanders RJ, Luo J, De Marzo AM, Isaacs WB. Peroxisomal branched chain fatty acid beta-oxidation pathway is upregulated in prostate cancer. The Prostate. 63: 316-23. PMID 15599942 DOI: 10.1002/pros.20177  1
2004 Zha S, Yegnasubramanian V, Nelson WG, Isaacs WB, De Marzo AM. Cyclooxygenases in cancer: progress and perspective. Cancer Letters. 215: 1-20. PMID 15374627 DOI: 10.1016/j.canlet.2004.06.014  0.32
2004 Rogers CG, Yan G, Zha S, Gonzalgo ML, Isaacs WB, Luo J, De Marzo AM, Nelson WG, Pavlovich CP. Prostate cancer detection on urinalysis for alpha methylacyl coenzyme a racemase protein. The Journal of Urology. 172: 1501-3. PMID 15371879  0.32
2003 Zha S, Ferdinandusse S, Denis S, Wanders RJ, Ewing CM, Luo J, De Marzo AM, Isaacs WB. Alpha-methylacyl-CoA racemase as an androgen-independent growth modifier in prostate cancer. Cancer Research. 63: 7365-76. PMID 14612535  0.32
2003 De Marzo AM, Meeker AK, Zha S, Luo J, Nakayama M, Platz EA, Isaacs WB, Nelson WG. Human prostate cancer precursors and pathobiology. Urology. 62: 55-62. PMID 14607218 DOI: 10.1016/j.urology.2003.09.053  1
2002 Luo J, Zha S, Gage WR, Dunn TA, Hicks JL, Bennett CJ, Ewing CM, Platz EA, Ferdinandusse S, Wanders RJ, Trent JM, Isaacs WB, De Marzo AM. Alpha-methylacyl-CoA racemase: a new molecular marker for prostate cancer. Cancer Research. 62: 2220-6. PMID 11956072  1
2001 Zha S, Gage WR, Sauvageot J, Saria EA, Putzi MJ, Ewing CM, Faith DA, Nelson WG, De Marzo AM, Isaacs WB. Cyclooxygenase-2 is up-regulated in proliferative inflammatory atrophy of the prostate, but not in prostate carcinoma. Cancer Research. 61: 8617-23. PMID 11751373  0.32
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