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Emmanuel Skordalakes - Publications

Affiliations: 
Chemistry University of Pennsylvania, Philadelphia, PA, United States 
Area:
Gene Expression and Regulation
Website:
http://webdev.chem.upenn.edu/chem/research/faculty.php?id=52

43/59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Zhu H, Ren S, Bitler BG, Aird KM, Tu Z, Skordalakes E, Zhu Y, Yan J, Sun Y, Zhang R. SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase. Cell Reports. PMID 26527005 DOI: 10.1016/J.Celrep.2015.09.083  0.92
2015 Bryan C, Rice C, Hoffman H, Harkisheimer M, Sweeney M, Skordalakes E. Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532. Structure (London, England : 1993). 23: 1934-42. PMID 26365799 DOI: 10.1016/J.Str.2015.08.006  0.92
2015 Greetham M, Skordalakes E, Lydall D, Connolly BA. The Telomere Binding Protein Cdc13 and the Single-Stranded DNA Binding Protein RPA Protect Telomeric DNA from Resection by Exonucleases. Journal of Molecular Biology. 427: 3023-30. PMID 26264873 DOI: 10.1016/J.Jmb.2015.08.002  0.92
2015 Iwasaki O, Tanizawa H, Kim KD, Yokoyama Y, Corcoran CJ, Tanaka A, Skordalakes E, Showe LC, Noma K. Interaction between TBP and Condensin Drives the Organization and Faithful Segregation of Mitotic Chromosomes. Molecular Cell. 59: 755-67. PMID 26257282 DOI: 10.1016/J.Molcel.2015.07.007  0.92
2015 Panneer Selvam S, De Palma RM, Oaks JJ, Oleinik N, Peterson YK, Stahelin RV, Skordalakes E, Ponnusamy S, Garrett-Mayer E, Smith CD, Ogretmen B. Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. Science Signaling. 8: ra58. PMID 26082434 DOI: 10.1126/Scisignal.Aaa4998  0.92
2014 Peng H, Talebzadeh-Farrooji M, Osborne MJ, Prokop JW, McDonald PC, Karar J, Hou Z, He M, Kebebew E, Orntoft T, Herlyn M, Caton AJ, Fredericks W, Malkowicz B, Paterno CS, ... ... Skordalakes E, et al. LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase. Cancer Research. 74: 1390-403. PMID 24590809 DOI: 10.1158/0008-5472.Can-13-1275  0.92
2014 Bryan C, Rice C, Harkisheimer M, Schultz D, Skordalakes E. Structure of the Human Telomeric Stn1-Ten1 Complex Acta Crystallographica Section A. 70. DOI: 10.1107/S2053273314084125  0.88
2013 Harkisheimer M, Mason M, Shuvaeva E, Skordalakes E. A motif in the vertebrate telomerase N-terminal linker of TERT contributes to RNA binding and telomerase activity and processivity. Structure (London, England : 1993). 21: 1870-8. PMID 24055314 DOI: 10.1016/J.Str.2013.08.013  0.92
2013 Bryan C, Rice C, Harkisheimer M, Schultz DC, Skordalakes E. Structure of the human telomeric Stn1-Ten1 capping complex. Plos One. 8: e66756. PMID 23826127 DOI: 10.1371/Journal.Pone.0066756  0.92
2013 Newhart A, Rafalska-Metcalf IU, Yang T, Joo LM, Powers SL, Kossenkov AV, Lopez-Jones M, Singer RH, Showe LC, Skordalakes E, Janicki SM. Single cell analysis of RNA-mediated histone H3.3 recruitment to a cytomegalovirus promoter-regulated transcription site. The Journal of Biological Chemistry. 288: 19882-99. PMID 23689370 DOI: 10.1074/Jbc.M113.473181  0.92
2013 Mason M, Wanat JJ, Harper S, Schultz DC, Speicher DW, Johnson FB, Skordalakes E. Cdc13 OB2 dimerization required for productive Stn1 binding and efficient telomere maintenance. Structure (London, England : 1993). 21: 109-20. PMID 23177925 DOI: 10.1016/J.Str.2012.10.012  0.92
2012 Skordalakes E, Lue NF. TERT Structure, Function, and Molecular Mechanisms Telomerases: Chemistry, Biology, and Clinical Applications. 53-78. DOI: 10.1002/9781118268667.ch3  0.92
2011 Schuller AP, Harkisheimer MJ, Skordalakes E. In vitro reconstitution of the active T. castaneum telomerase. Journal of Visualized Experiments : Jove. e2799. PMID 21775967 DOI: 10.3791/2799  0.92
2011 Mason M, Schuller A, Skordalakes E. Telomerase structure function. Current Opinion in Structural Biology. 21: 92-100. PMID 21168327 DOI: 10.1016/J.Sbi.2010.11.005  0.92
2010 Song Y, Willer JR, Scherer PC, Panzer JA, Kugath A, Skordalakes E, Gregg RG, Willer GB, Balice-Gordon RJ. Neural and synaptic defects in slytherin, a zebrafish model for human congenital disorders of glycosylation. Plos One. 5: e13743. PMID 21060795 DOI: 10.1371/Journal.Pone.0013743  0.92
2010 Mason M, Skordalakes E. Insights into Cdc13 dependent telomere length regulation. Aging. 2: 731-4. PMID 20975208  0.92
2010 Mitchell MT, Smith JS, Mason M, Harper S, Speicher DW, Johnson FB, Skordalakes E. Cdc13 N-terminal dimerization, DNA binding, and telomere length regulation. Molecular and Cellular Biology. 30: 5325-34. PMID 20837709 DOI: 10.1128/Mcb.00515-10  0.92
2010 Mitchell M, Gillis A, Futahashi M, Fujiwara H, Skordalakes E. Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA. Nature Structural & Molecular Biology. 17: 513-8. PMID 20357774 DOI: 10.1038/Nsmb.1777  0.92
2010 McCray BA, Skordalakes E, Taylor JP. Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation. Human Molecular Genetics. 19: 1033-47. PMID 20028791 DOI: 10.1093/Hmg/Ddp567  0.92
2009 Wang AY, Schulze JM, Skordalakes E, Gin JW, Berger JM, Rine J, Kobor MS. Asf1-like structure of the conserved Yaf9 YEATS domain and role in H2A.Z deposition and acetylation. Proceedings of the National Academy of Sciences of the United States of America. 106: 21573-8. PMID 19966225 DOI: 10.1073/Pnas.0906539106  0.92
2009 Skordalakes E. Telomerase structure paves the way for new cancer therapies. Future Oncology (London, England). 5: 163-7. PMID 19284375 DOI: 10.2217/14796694.5.2.163  0.92
2009 Gillis A, Schuller A, Skordalakes E. Structure of the catalytic subunit of telomerase; a major target for cancer and aging therapies Acta Crystallographica Section A. 65. DOI: 10.1107/S0108767309099619  0.32
2008 Skordalakes E. Telomerase and the benefits of healthy living. The Lancet. Oncology. 9: 1023-4. PMID 19012852 DOI: 10.1016/S1470-2045(08)70266-3  0.92
2008 Gillis AJ, Schuller AP, Skordalakes E. Structure of the Tribolium castaneum telomerase catalytic subunit TERT. Nature. 455: 633-7. PMID 18758444 DOI: 10.1038/Nature07283  0.92
2008 Carlson BL, Ballister ER, Skordalakes E, King DS, Breidenbach MA, Gilmore SA, Berger JM, Bertozzi CR. Function and structure of a prokaryotic formylglycine-generating enzyme. The Journal of Biological Chemistry. 283: 20117-25. PMID 18390551 DOI: 10.1074/Jbc.M800217200  0.92
2007 Rouda S, Skordalakes E. Structure of the RNA-binding domain of telomerase: implications for RNA recognition and binding. Structure (London, England : 1993). 15: 1403-12. PMID 17997966 DOI: 10.1016/J.Str.2007.09.007  0.92
2007 Young TA, Skordalakes E, Marqusee S. Comparison of proteolytic susceptibility in phosphoglycerate kinases from yeast and E. coli: modulation of conformational ensembles without altering structure or stability. Journal of Molecular Biology. 368: 1438-47. PMID 17397866 DOI: 10.1016/J.Jmb.2007.02.077  0.92
2006 Skordalakes E, Berger JM. Structural insights into RNA-dependent ring closure and ATPase activation by the Rho termination factor. Cell. 127: 553-64. PMID 17081977 DOI: 10.1016/J.Cell.2006.08.051  0.92
2005 Skordalakes E, Brogan AP, Park BS, Kohn H, Berger JM. Structural mechanism of inhibition of the Rho transcription termination factor by the antibiotic bicyclomycin. Structure (London, England : 1993). 13: 99-109. PMID 15642265 DOI: 10.1016/J.Str.2004.10.013  0.92
2003 Daganzo SM, Erzberger JP, Lam WM, Skordalakes E, Zhang R, Franco AA, Brill SJ, Adams PD, Berger JM, Kaufman PD. Structure and function of the conserved core of histone deposition protein Asf1. Current Biology : Cb. 13: 2148-58. PMID 14680630 DOI: 10.1016/J.Cub.2003.11.027  0.92
2003 Skordalakes E, Berger JM. Structure of the Rho transcription terminator: mechanism of mRNA recognition and helicase loading. Cell. 114: 135-46. PMID 12859904 DOI: 10.1016/S0092-8674(03)00512-9  0.92
2001 Skordalakes E, Dodson GG, Green DS, Goodwin CA, Scully MF, Hudson HR, Kakkar VV, Deadman JJ. Inhibition of human alpha-thrombin by a phosphonate tripeptide proceeds via a metastable pentacoordinated phosphorus intermediate. Journal of Molecular Biology. 311: 549-55. PMID 11493008 DOI: 10.1006/Jmbi.2001.4872  0.92
2000 Green D, Elgendy S, Patel G, Skordalakes E, Goodwin CA, Scully MF, Kakkar VV, Deadman JJ. Substrate related O,O-dialkyldipeptidylψ carboxybenzylphosphonates, a new type of thrombin inhibitor Phosphorus, Sulfur and Silicon and Related Elements. 156: 151-155. DOI: 10.1080/10426500008044999  0.92
1999 Green D, Skordalakes E, Scully MF, Goodwin C, Merette S, Burd A, Kakkar VV, Deadman J. X-ray crystallographic analyses of human α-thrombin complexed to peptidyl aminophosphonates: Evidence of a binding mechanism Phosphorus, Sulfur and Silicon and Related Elements. 144: 545-548. DOI: 10.1080/10426509908546302  0.92
1998 Skordalakes E, Elgendy S, Goodwin CA, Green D, Scully MF, Kakkar VV, Freyssinet JM, Dodson G, Deadman JJ. Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide. Biochemistry. 37: 14420-7. PMID 9772168 DOI: 10.1021/Bi980225A  0.92
1997 Skordalakes E, Tyrell R, Elgendy S, Goodwin CA, Green D, Dodson G, Scully MF, Freyssinet JMH, Kakkar VV, Deadman JJ. Crystallographic structures of human α-thrombin complexed to peptide boronic acids lacking a positive charge at P1. Evidence of novel interactions Journal of the American Chemical Society. 119: 9935-9936. DOI: 10.1021/Ja9713338  0.92
1997 Elgendy S, Patel G, Green D, Goodwin CA, Scully MF, Husman W, Skordalakes E, Kakkar VV, Deadman JJ. Design of a novel class of bifunctional thrombin inhibitors, synthesised by the first application of peptide boronates in solid phase chemistry Tetrahedron Letters. 38: 3305-3308. DOI: 10.1016/S0040-4039(97)00592-3  0.92
1996 Green D, Patel G, Elgendy S, Baban JA, Skordalakes E, Husman W, Goodwin CA, Scully MF, Kakkar VV, Deadman J. Substrate related O,O-dialkyldipeptidylaminophosphonates, a new type of thrombin inhibitor Phosphorus, Sulfur and Silicon and Related Elements. 109: 533-536. DOI: 10.1080/10426509608545208  0.92
1996 Green D, Elgendy S, Patel G, Baban JA, Skordalakes E, Husman W, Kakkar VV, Deadman J. The facile synthesis of 1-aminophosphonates from 1-nitrophosphonate precursors Phosphorus, Sulfur and Silicon and Related Elements. 113: 303-306. DOI: 10.1080/10426509608046403  0.92
1996 Green D, Elgendy S, Patel G, Skordalakes E, Husman W, Kakkar VV, Deadman J. The synthesis and fab mass analysis of O,O-dialkyl 1-benzylaminobenzylphosphonates, precursors of important structural units in anti-thrombotic tripeptides Phosphorus, Sulfur and Silicon and Related Elements. 118: 271-291. DOI: 10.1080/10426509608038819  0.92
1996 Green D, Elgendy S, Patel G, Baban JA, Skordalakes E, Husman W, Kakkar VV, Deadman J. The facile synthesis of O,O-dialkyl α-halobenzylphosphonates from O,O-dialkyl α-hydroxybenzylphosphonates Tetrahedron. 52: 10215-10224. DOI: 10.1016/0040-4020(96)00556-X  0.92
1995 Deadman JJ, Elgendy S, Goodwin CA, Green D, Baban JA, Patel G, Skordalakes E, Chino N, Claeson G, Kakkar VV. Characterization of a class of peptide boronates with neutral P1 side chains as highly selective inhibitors of thrombin. Journal of Medicinal Chemistry. 38: 1511-22. PMID 7739010  0.92
1994 Elgendy S, Patel G, Kakkar VV, Claeson G, Green D, Skordalakes E, Baban JA, Deadman J. Rhodium(I)-catalysed hydroboration of 1-halo-1-alkenes Tetrahedron Letters. 35: 2435-2436. DOI: 10.1016/0040-4039(94)85239-1  0.92
Low-probability matches
2017 Rice C, Shastrula PK, Kossenkov AV, Hills R, Baird DM, Showe LC, Doukov T, Janicki S, Skordalakes E. Structural and functional analysis of the human POT1-TPP1 telomeric complex. Nature Communications. 8: 14928. PMID 28393830 DOI: 10.1038/Ncomms14928  0.28
2017 Hoffman H, Rice C, Skordalakes E. Structural Analysis Reveals the Deleterious Effects of Telomerase Mutations in Telomerase-Associated Bone Marrow Failure Syndromes. The Journal of Biological Chemistry. PMID 28154186 DOI: 10.1074/Jbc.M116.771204  0.28
2016 Rice C, Skordalakes E. Structure and function of the telomeric CST complex. Computational and Structural Biotechnology Journal. 14: 161-7. PMID 27239262 DOI: 10.1016/J.Csbj.2016.04.002  0.28
2019 Seo JH, Chae YC, Kossenkov AV, Lee YG, Tang HY, Agarwal E, Gabrilovich DI, Languino LR, Speicher DW, Shastrula PK, Storaci AM, Ferrero S, Gaudioso G, Caroli M, Tosi D, ... ... Skordalakes E, et al. MFF REGULATION OF MITOCHONDRIAL CELL DEATH IS A THERAPEUTIC TARGET IN CANCER. Cancer Research. PMID 31582380 DOI: 10.1158/0008-5472.Can-19-1982  0.24
2017 Sakurai M, Shiromoto Y, Ota H, Song C, Kossenkov AV, Wickramasinghe J, Showe LC, Skordalakes E, Tang HY, Speicher DW, Nishikura K. ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay. Nature Structural & Molecular Biology. PMID 28436945 DOI: 10.1038/Nsmb.3403  0.24
2014 Peng H, Farrooji MTZ, Osborne MJ, Prokop JW, McDonald PC, Karar J, Hou Z, He M, Kebebew E, Orntoft T, Herlyn M, Caton AJ, Fredericks W, Malkowicz B, Paterno CS, ... ... Skordalakes E, et al. Abstract 992: LIMD2 is a small LIM-only protein overexpressed in metastatic lesions which regulates cell motility and tumor progression by directly binding to and activating the integrin-linked-kinase Cancer Research. 74: 992-992. DOI: 10.1158/1538-7445.Am2014-992  0.24
2002 Hansen CL, Skordalakes E, Berger JM, Quake SR. A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion. Proceedings of the National Academy of Sciences of the United States of America. 99: 16531-6. PMID 12486223 DOI: 10.1073/Pnas.262485199  0.12
2019 Hernandez-Sanchez W, Huang W, Plucinsky B, Garcia-Vazquez N, Robinson NJ, Schiemann WP, Berdis AJ, Skordalakes E, Taylor DJ. A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity. Plos Biology. 17: e3000204. PMID 30951520 DOI: 10.1371/Journal.Pbio.3000204  0.04
2021 Kelich JM, Papaioannou H, Skordalakes E. Pol α-primase dependent nuclear localization of the mammalian CST complex. Communications Biology. 4: 349. PMID 33731801 DOI: 10.1038/s42003-021-01845-4  0.01
2021 Miller KD, Pniewski K, Perry CE, Papp SB, Shaffer JD, Velasco-Silva JN, Casciano JC, Aramburu TM, Srikanth YVV, Cassel J, Skordalakes E, Kossenkov AV, Salvino JM, Schug ZT. Targeting ACSS2 with a transition state mimetic inhibits triple-negative breast cancer growth. Cancer Research. PMID 33414169 DOI: 10.1158/0008-5472.CAN-20-1847  0.01
2020 Chen K, Jiao X, Di Rocco A, Shen D, Xu S, Ertel A, Yu Z, Di Sante G, Wang M, Li Z, Pestell TG, Casimiro MC, Skordalakes E, Achilefu S, Pestell RG. Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation. Cell Reports. 32: 108151. PMID 32937140 DOI: 10.1016/J.Celrep.2020.108151  0.01
2020 Aramburu T, Plucinsky S, Skordalakes E. POT1-TPP1 telomere length regulation and disease. Computational and Structural Biotechnology Journal. 18: 1939-1946. PMID 32774788 DOI: 10.1016/J.Csbj.2020.06.040  0.01
2020 Ren W, Medeiros N, Warneford-Thomson R, Wulfridge P, Yan Q, Bian J, Sidoli S, Garcia BA, Skordalakes E, Joyce E, Bonasio R, Sarma K. Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function. Nature Communications. 11: 2219. PMID 32376827 DOI: 10.1038/S41467-020-15902-9  0.01
2019 Di Sante G, Pagé J, Jiao X, Nawab O, Cristofanilli M, Skordalakes E, Pestell RG. Recent advances with cyclin-dependent kinase inhibitors: therapeutic agents for breast cancer and their role in immuno-oncology. Expert Review of Anticancer Therapy. 1-19. PMID 31219365 DOI: 10.1080/14737140.2019.1615889  0.01
2017 Shastrula PK, Rice CT, Wang Z, Lieberman PM, Skordalakes E. Structural and functional analysis of an OB-fold in human Ctc1 implicated in telomere maintenance and bone marrow syndromes. Nucleic Acids Research. PMID 29228254 DOI: 10.1093/Nar/Gkx1213  0.01
2016 Hoffman H, Skordalakes E. Crystallographic Studies of Telomerase. Methods in Enzymology. 573: 403-19. PMID 27372764 DOI: 10.1016/Bs.Mie.2016.04.006  0.01
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