Pengyu Yang, Ph.D. - Publications

2011-2017 Chemistry Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Chemistry, Chemical Biology, Translational Medicine

35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Yang PY, Zou H, Amso Z, Lee C, Huang D, Woods AK, Nguyen-Tran VTB, Schultz PG, Shen W.. New Generation Oxyntomodulin Peptides with Improved Pharmacokinetic Profiles Exhibit Weight Reducing and Anti-Steatotic Properties in Mice Bioconjugate Chem. 31: 1167. PMID 32243137 DOI: 10.1021/acs.bioconjchem.0c00093  1
2019 Li B, Zhou XH, Yang PY, Zhu L, Zhong Y, Cai Z, Jiang B, Cai X, Liu J, Jiang X. Photoactivatable Fluorogenic Labeling via Turn-On "Click-Like" Nitroso-Diene Bioorthogonal Reaction Adv Sci (Weinh).. 6: 1802039. PMID 31380178 DOI: 10.1002/advs.201802039  1
2018 Zhao Q, Xu H, Hong S, Song N, Xie J, Yan Z, Wang R, Yang P, Jiang X. Rapeseed protein-derived antioxidant peptide RAP ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice. Molecular Pharmaceutics. PMID 30543441 DOI: 10.1021/acs.molpharmaceut.8b01030  1
2018 Muppidi A, Lee SJ, Hsu CH, Zou H, Lee C, Pflimlin E, Mahankali M, Yang P, Chao E, Ahmad I, Crameri A, Wang D, Woods A, Shen W. Design and Synthesis of Potent, Long-Acting Lipidated Relaxin-2 Analogs. Bioconjugate Chemistry. PMID 30543420 DOI: 10.1021/acs.bioconjchem.8b00764  1
2018 Yang P, Zou H, Lee C, Muppidi A, Chao E, Fu Q, Luo X, Wang D, Schultz PG, Shen W. A Stapled, Long-Acting Glucagon-like Peptide 2 Analog with Efficacy in Dextran Sodium Sulfate-Induced Mouse Colitis Models. Journal of Medicinal Chemistry. PMID 29528634 DOI: 10.1021/acs.jmedchem.7b00768  1
2016 Wang Y, Du J, Zou H, Liu Y, Zhang Y, Gonzalez J, Chao E, Lu L, Yang P, Parker H, Nguyen-Tran V, Shen W, Wang D, Schultz PG, Wang F. Multifunctional Antibody Agonists Targeting Glucagon-like Peptide-1, Glucagon, and Glucose-Dependent Insulinotropic Polypeptide Receptors. Angewandte Chemie (International Ed. in English). PMID 27595986 DOI: 10.1002/anie.201606321  1
2016 Cao Y, Rodgers DT, Du J, Ahmad I, Hampton EN, Ma JS, Mazagova M, Choi SH, Yun HY, Xiao H, Yang P, Luo X, Lim RK, Pugh HM, Wang F, et al. Design of Switchable Chimeric Antigen Receptor T Cells Targeting Breast Cancer. Angewandte Chemie (International Ed. in English). 55: 7520-4. PMID 27145250 DOI: 10.1002/anie.201601902  1
2016 Yang PY, Zou H, Chao E, Sherwood L, Nunez V, Keeney M, Ghartey-Tagoe E, Ding Z, Quirino H, Luo X, Welzel G, Chen G, Singh P, Woods AK, Schultz PG, et al. Engineering a long-acting, potent GLP-1 analog for microstructure-based transdermal delivery. Proceedings of the National Academy of Sciences of the United States of America. 113: 4140-5. PMID 27035989 DOI: 10.1073/pnas.1601653113  1
2016 Luo X, Zambaldo C, Liu T, Zhang Y, Xuan W, Wang C, Reed SA, Yang PY, Wang RE, Javahishvili T, Schultz PG, Young TS. Recombinant thiopeptides containing noncanonical amino acids. Proceedings of the National Academy of Sciences of the United States of America. 113: 3615-20. PMID 26976568 DOI: 10.1073/pnas.1602733113  1
2016 Muppidi A, Zou H, Yang PY, Chao E, Sherwood L, Nunez V, Woods AK, Schultz PG, Lin Q, Shen W. Design of Potent and Proteolytically Stable Oxyntomodulin Analogs. Acs Chemical Biology. 11: 324-8. PMID 26727558 DOI: 10.1021/acschembio.5b00787  1
2015 Yang P, Liu K. Activity-based protein profiling: recent advances in probe development and applications. Chembiochem : a European Journal of Chemical Biology. 16: 712-24. PMID 25652106 DOI: 10.1002/cbic.201402582  1
2014 Xiao H, Peters FB, Yang PY, Reed S, Chittuluru JR, Schultz PG. Genetic incorporation of histidine derivatives using an engineered pyrrolysyl-tRNA synthetase. Acs Chemical Biology. 9: 1092-6. PMID 24506189 DOI: 10.1021/cb500032c  1
2013 Wang F, Sambandan D, Halder R, Wang J, Batt SM, Weinrick B, Ahmad I, Yang P, Zhang Y, Kim J, Hassani M, Huszar S, Trefzer C, Ma Z, Kaneko T, et al. Identification of a small molecule with activity against drug-resistant and persistent tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 110: E2510-7. PMID 23776209 DOI: 10.1073/pnas.1309171110  1
2013 Nasheri N, Joyce M, Rouleau Y, Yang P, Yao S, Tyrrell DL, Pezacki JP. Modulation of fatty acid synthase enzyme activity and expression during hepatitis C virus replication. Chemistry & Biology. 20: 570-82. PMID 23601646 DOI: 10.1016/j.chembiol.2013.03.014  1
2013 Chatterjee A, Xiao H, Yang PY, Soundararajan G, Schultz PG. A tryptophanyl-tRNA synthetase/tRNA pair for unnatural amino acid mutagenesis in E. coli. Angewandte Chemie (International Ed. in English). 52: 5106-9. PMID 23554007 DOI: 10.1002/anie.201301094  1
2012 Wang D, Wang J, Bonamy GM, Meeusen S, Brusch RG, Turk C, Yang P, Schultz PG. A small molecule promotes mitochondrial fusion in mammalian cells. Angewandte Chemie (International Ed. in English). 51: 9302-5. PMID 22907892 DOI: 10.1002/anie.201204589  1
2012 Yang PY, Wang M, Liu K, Ngai MH, Sheriff O, Lear MJ, Sze SK, He CY, Yao SQ. Parasite-based screening and proteome profiling reveal orlistat, an FDA-approved drug, as a potential anti Trypanosoma brucei agent. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 8403-13. PMID 22674877 DOI: 10.1002/chem.201200482  1
2012 Yang PY, Wang M, Li L, Wu H, He CY, Yao SQ. Design, synthesis and biological evaluation of potent azadipeptide nitrile inhibitors and activity-based probes as promising anti-Trypanosoma brucei agents. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 6528-41. PMID 22488888 DOI: 10.1002/chem.201103322  1
2012 Yang PY, Wang M, He CY, Yao SQ. Proteomic profiling and potential cellular target identification of K11777, a clinical cysteine protease inhibitor, in Trypanosoma brucei. Chemical Communications (Cambridge, England). 48: 835-7. PMID 22124229 DOI: 10.1039/c1cc16178d  1
2011 Yang PY, Liu K, Zhang C, Chen GY, Shen Y, Ngai MH, Lear MJ, Yao SQ. Chemical modification and organelle-specific localization of orlistat-like natural-product-based probes. Chemistry, An Asian Journal. 6: 2762-75. PMID 21744505 DOI: 10.1002/asia.201100306  1
2011 Hu M, Li L, Wu H, Su Y, Yang PY, Uttamchandani M, Xu QH, Yao SQ. Multicolor, one- and two-photon imaging of enzymatic activities in live cells with fluorescently Quenched Activity-Based Probes (qABPs). Journal of the American Chemical Society. 133: 12009-20. PMID 21732629 DOI: 10.1021/ja200808y  1
2011 Liu K, Yang PY, Na Z, Yao SQ. Dynamic monitoring of newly synthesized proteomes: up-regulation of myristoylated protein kinase A during butyric acid induced apoptosis. Angewandte Chemie (International Ed. in English). 50: 6776-81. PMID 21678537 DOI: 10.1002/anie.201102542  1
2011 Wu H, Ge J, Yang PY, Wang J, Uttamchandani M, Yao SQ. A peptide aldehyde microarray for high-throughput profiling of cellular events. Journal of the American Chemical Society. 133: 1946-54. PMID 21247160 DOI: 10.1021/ja109597v  1
2010 Ngai MH, Yang PY, Liu K, Shen Y, Wenk MR, Yao SQ, Lear MJ. Click-based synthesis and proteomic profiling of lipstatin analogues. Chemical Communications (Cambridge, England). 46: 8335-7. PMID 20577697 DOI: 10.1039/c0cc01276a  1
2010 Yang PY, Liu K, Ngai MH, Lear MJ, Wenk MR, Yao SQ. Activity-based proteome profiling of potential cellular targets of Orlistat--an FDA-approved drug with anti-tumor activities. Journal of the American Chemical Society. 132: 656-66. PMID 20028024 DOI: 10.1021/ja907716f  1
2009 Tan LP, Wu H, Yang PY, Kalesh KA, Zhang X, Hu M, Srinivasan R, Yao SQ. High-throughput discovery of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitors using click chemistry. Organic Letters. 11: 5102-5. PMID 19852491 DOI: 10.1021/ol9023419  1
2009 Srinivasan R, Tan LP, Wu H, Yang PY, Kalesh KA, Yao SQ. High-throughput synthesis of azide libraries suitable for direct "click" chemistry and in situ screening. Organic & Biomolecular Chemistry. 7: 1821-8. PMID 19590777 DOI: 10.1039/b902338k  1
2008 Yang PY, Wu H, Lee MY, Xu A, Srinivasan R, Yao SQ. Solid-phase synthesis of azidomethylene inhibitors targeting cysteine proteases. Organic Letters. 10: 1881-4. PMID 18407644 DOI: 10.1021/ol800575z  1
2008 Ng SL, Yang PY, Chen KY, Srinivasan R, Yao SQ. "Click" synthesis of small-molecule inhibitors targeting caspases. Organic & Biomolecular Chemistry. 6: 844-7. PMID 18292873 DOI: 10.1039/b718304f  1
2006 Shi JC, Yang PY, Tong Q, Wu Y, Peng Y. Highly efficient and stable palladium/imidazolium salt-phosphine catalysts for Suzuki–Miyaura cross-coupling of aryl bromides Journal of Molecular Catalysis a: Chemical. 259: 7. DOI: 10.1016/j.molcata.2006.04.025  1
2006 Yu HW, Shi JC, Zahng H, Yang PY, Wang XP, Jin ZL. Unsymmetric-1, 3-disubstituted imidazolium salt for palladium-catalyzed Suzuki–Miyaura cross-coupling reactions of aryl bromides Journal of Molecular Catalysis a: Chemical. 250: 15. DOI: 10.1016/j.molcata.2006.01.034  1
2005 Yang G, Han X, Zhang W, Liu X, Yang P, Zhou Y, Bao X. Study on conformation interconversion of 3-alkyl-4-acetyl-3,4-dihydro-2H-1,4-benzoxazines from dynamic NMR experiments and ab initio density functional calculations. The Journal of Physical Chemistry. B. 109: 18690-8. PMID 16853404 DOI: 10.1021/jp050874d  0.64
2005 Zhou YG, Yang P, HAN XW. Synthesis and Highly Enantioselective Hydrogenation of Exocyclic Enamides:(Z)-3-Arylidene-4-acetyl-3, 4-dihydro-2 H-1, 4-benzoxazines The Journal of Organic Chemistry. 70: 1679. PMID 15730287 DOI: 10.1021/jo048212s  1
2004 Wang WB, Lu SM, Yang PY, Han XW, Zhou YG. Highly enantioselective iridium-catalyzed hydrogenation of heteroaromatic compounds, quinolines Journal of the American Chemical Society. 125: 10536. PMID 12940733 DOI: 10.1021/ja0353762  1
2004 Yang PY, Zhou YG. The enantioselective total synthesis of alkaloid (−)-galipeine Tetrahedron: Asymmetry. 15: 1145. DOI: 10.1016/j.tetasy.2004.02.012  1
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