Costas Lyssiotis - Publications

Affiliations: 
Chemistry Scripps Research Institute, La Jolla, La Jolla, CA, United States 

68 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Ji L, Lee HJ, Wan G, Wang GP, Zhang L, Sajjakulnukit P, Schacht J, Lyssiotis CA, Corfas G. Auditory metabolomics, an approach to identify acute molecular effects of noise trauma. Scientific Reports. 9: 9273. PMID 31239523 DOI: 10.1038/s41598-019-45385-8  0.48
2019 Libiad M, Vitvitsky V, Bostelaar T, Bak DW, Lee HJ, Sakamoto N, Fearon ER, Lyssiotis CA, Weerapana E, Banerjee R. Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells. The Journal of Biological Chemistry. PMID 31213529 DOI: 10.1074/jbc.RA119.009442  0.4
2019 Li M, Chiang YL, Lyssiotis CA, Teater MR, Hong JY, Shen H, Wang L, Hu J, Jing H, Chen Z, Jain N, Duy C, Mistry SJ, Cerchietti L, Cross JR, et al. Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis. Cancer Cell. 35: 916-931.e9. PMID 31185214 DOI: 10.1016/j.ccell.2019.05.002  1
2019 Xu J, Reznik E, Lee HJ, Gundem G, Jonsson P, Sarungbam J, Bialik A, Sanchez-Vega F, Creighton CJ, Hoekstra JG, Zhang L, Sajjakulnukit P, Kremer D, Tolstyka ZP, Casuscelli J, ... ... Lyssiotis C, et al. Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma. Elife. 8. PMID 30924768 DOI: 10.7554/eLife.38986  0.48
2019 Bryant KL, Stalnecker CA, Zeitouni D, Klomp JE, Peng S, Tikunov AP, Gunda V, Pierobon M, Waters AM, George SD, Tomar G, Papke B, Hobbs GA, Yan L, Hayes TK, ... ... Lyssiotis CA, et al. Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer. Nature Medicine. PMID 30833752 DOI: 10.1038/s41591-019-0368-8  1
2019 Halbrook CJ, Pontious C, Kovalenko I, Lapienyte L, Dreyer S, Lee HJ, Thurston G, Zhang Y, Lazarus J, Sajjakulnukit P, Hong HS, Kremer DM, Nelson BS, Kemp S, Zhang L, ... ... Lyssiotis CA, et al. Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer. Cell Metabolism. PMID 30827862 DOI: 10.1016/j.cmet.2019.02.001  1
2019 Núñez FJ, Mendez FM, Kadiyala P, Alghamri MS, Savelieff MG, Garcia-Fabiani MB, Haase S, Koschmann C, Calinescu AA, Kamran N, Saxena M, Patel R, Carney S, Guo MZ, Edwards M, ... ... Lyssiotis CA, et al. IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response. Science Translational Medicine. 11. PMID 30760578 DOI: 10.1126/scitranslmed.aaq1427  0.84
2019 Yuan M, Kremer DM, Huang H, Breitkopf SB, Ben-Sahra I, Manning BD, Lyssiotis CA, Asara JM. Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC-MS/MS. Nature Protocols. PMID 30683937 DOI: 10.1038/s41596-018-0102-x  1
2018 Santana-Codina N, Roeth AA, Zhang Y, Yang A, Mashadova O, Asara JM, Wang X, Bronson RT, Lyssiotis CA, Ying H, Kimmelman AC. Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis. Nature Communications. 9: 4945. PMID 30470748 DOI: 10.1038/s41467-018-07472-8  1
2018 Holt MC, Assar Z, Beheshti Zavareh R, Lin L, Anglin J, Mashadova O, Haldar D, Mullarky E, Kremer DM, Cantley LC, Kimmelman AC, Stein AJ, Lairson LL, Lyssiotis CA. Biochemical Characterization and Structure-based Mutational Analysis Provides Insight into Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. Biochemistry. PMID 30365304 DOI: 10.1021/acs.biochem.8b00914  1
2018 Nelson BS, Kremer DM, Lyssiotis CA. New tricks for an old drug. Nature Chemical Biology. 14: 990-991. PMID 30297874 DOI: 10.1038/s41589-018-0137-x  0.84
2018 Anglin J, Zavareh RB, Sander PN, Haldar D, Mullarky E, Cantley LC, Kimmelman AC, Lyssiotis CA, Lairson LL. Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma. Bioorganic & Medicinal Chemistry Letters. PMID 29731362 DOI: 10.1016/j.bmcl.2018.04.061  1
2018 Halbrook CJ, Nwosu ZC, Lyssiotis CA. Fine-Tuning Mitochondrial Dysfunction and Reductive Carboxylation. Trends in Endocrinology and Metabolism: Tem. PMID 29692332 DOI: 10.1016/j.tem.2018.04.002  0.52
2018 Svoboda LK, Teh SSK, Sud S, Kerk S, Zebolsky A, Treichel S, Thomas D, Halbrook CJ, Lee HJ, Kremer D, Zhang L, Klossowski S, Bankhead AR, Magnuson B, Ljungman M, ... ... Lyssiotis CA, et al. Menin regulates the serine biosynthetic pathway in Ewing sarcoma. The Journal of Pathology. PMID 29672864 DOI: 10.1002/path.5085  0.52
2018 Halbrook CJ, Pasca di Magliano M, Lyssiotis CA. TUMOR CROSSTALK NETWORKS PROMOTE GROWTH AND SUPPORT IMMUNE EVASION IN PANCREATIC CANCER. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 29543507 DOI: 10.1152/ajpgi.00416.2017  0.52
2018 Schofield HK, Zeller J, Espinoza C, Halbrook CJ, Del Vecchio A, Magnuson B, Fabo T, Daylan AEC, Kovalenko I, Lee HJ, Yan W, Feng Y, Karim SA, Kremer DM, Kumar-Sinha C, ... Lyssiotis CA, et al. Mutant p53R270H drives altered metabolism and increased invasion in pancreatic ductal adenocarcinoma. Jci Insight. 3. PMID 29367463 DOI: 10.1172/jci.insight.97422  0.84
2017 Shan M, Lyssiotis CA. When Cancer Cells Are Given Lemo[NH3]s, They Make Lemo[NH3]ade. Cell Metabolism. 26: 811-813. PMID 29211980 DOI: 10.1016/j.cmet.2017.11.008  0.56
2017 Bollong MJ, Pietilä M, Pearson AD, Sarkar TR, Ahmad I, Soundararajan R, Lyssiotis CA, Mani SA, Schultz PG, Lairson LL. A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. Proceedings of the National Academy of Sciences of the United States of America. PMID 29087350 DOI: 10.1073/pnas.1716009114  1
2017 Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, ... ... Lyssiotis CA, et al. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 32: 392. PMID 28898700 DOI: 10.1016/j.ccell.2017.08.008  1
2017 Lyssiotis CA, Kimmelman AC. Metabolic Interactions in the Tumor Microenvironment. Trends in Cell Biology. PMID 28734735 DOI: 10.1016/j.tcb.2017.06.003  1
2017 Lee HJ, Jedrychowski MP, Vinayagam A, Wu N, Shyh-Chang N, Hu Y, Min-Wen C, Moore JK, Asara JM, Lyssiotis CA, Perrimon N, Gygi SP, Cantley LC, Kirschner MW. Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation. Cell Reports. 20: 721-736. PMID 28723573 DOI: 10.1016/j.celrep.2017.06.074  1
2017 Bringman-Rodenbarger LR, Guo AH, Lyssiotis CA, Lombard DB. Emerging roles for SIRT5 in metabolism and cancer. Antioxidants & Redox Signaling. PMID 28707979 DOI: 10.1089/ars.2017.7264  0.76
2017 Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, ... ... Lyssiotis CA, et al. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 32: 71-87.e7. PMID 28697344 DOI: 10.1016/j.ccell.2017.06.004  1
2017 Franchi L, Monteleone I, Hao LY, Spahr MA, Zhao W, Liu X, Demock K, Kulkarni A, Lesch CA, Sanchez B, Carter L, Marafini I, Hu X, Mashadova O, Yuan M, ... ... Lyssiotis CA, et al. Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis. Journal of Immunology (Baltimore, Md. : 1950). PMID 28242647 DOI: 10.4049/jimmunol.1600810  1
2017 Halbrook CJ, Lyssiotis CA. Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer. Cancer Cell. 31: 5-19. PMID 28073003 DOI: 10.1016/j.ccell.2016.12.006  0.52
2016 Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC. Erratum: Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. PMID 27706144 DOI: 10.1038/nature19851  1
2016 Mullarky E, Lairson LL, Cantley LC, Lyssiotis CA. A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase. Molecular & Cellular Oncology. 3: e1164280. PMID 27652319 DOI: 10.1080/23723556.2016.1164280  1
2016 Meyer KA, Neeley CK, Baker NA, Washabaugh AR, Flesher CG, Nelson BS, Frankel TL, Lumeng CN, Lyssiotis CA, Wynn ML, Rhim AD, O'Rourke RW. Adipocytes promote pancreatic cancer cell proliferation via glutamine transfer. Biochemistry and Biophysics Reports. 7: 144-149. PMID 27617308 DOI: 10.1016/j.bbrep.2016.06.004  0.84
2016 Lien EC, Lyssiotis CA, Cantley LC. Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer. Recent Results in Cancer Research. Fortschritte Der Krebsforschung. ProgrèS Dans Les Recherches Sur Le Cancer. 207: 39-72. PMID 27557534 DOI: 10.1007/978-3-319-42118-6_3  1
2016 Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC. Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. PMID 27509858 DOI: 10.1038/nature19084  1
2016 Juvekar A, Hu H, Yadegarynia S, Lyssiotis CA, Ullas S, Lien EC, Bellinger G, Son J, Hok RC, Seth P, Daly MB, Kim B, Scully R, Asara JM, Cantley LC, et al. Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion. Proceedings of the National Academy of Sciences of the United States of America. PMID 27402769 DOI: 10.1073/pnas.1522223113  1
2016 Lien EC, Lyssiotis CA, Juvekar A, Hu H, Asara JM, Cantley LC, Toker A. Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer. Nature Cell Biology. PMID 27088857 DOI: 10.1038/ncb3341  1
2016 Mullarky E, Lucki NC, Beheshti Zavareh R, Anglin JL, Gomes AP, Nicolay BN, Wong JC, Christen S, Takahashi H, Singh PK, Blenis J, Warren JD, Fendt SM, Asara JM, DeNicola GM, ... Lyssiotis CA, et al. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proceedings of the National Academy of Sciences of the United States of America. PMID 26831078 DOI: 10.1073/pnas.1521548113  1
2016 Hu H, Juvekar A, Lyssiotis CA, Lien EC, Albeck JG, Oh D, Varma G, Hung YP, Ullas S, Lauring J, Seth P, Lundquist MR, Tolan DR, Grant AK, Needleman DJ, et al. Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton. Cell. 164: 433-446. PMID 26824656 DOI: 10.1016/j.cell.2015.12.042  1
2015 Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin AR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, ... ... Lyssiotis CA, et al. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Seminars in Cancer Biology. 35: S276-304. PMID 26590477 DOI: 10.1016/j.semcancer.2015.09.007  0.04
2015 Chakrabarti G, Moore ZR, Luo X, Ilcheva M, Ali A, Padanad M, Zhou Y, Xie Y, Burma S, Scaglioni PP, Cantley LC, DeBerardinis RJ, Kimmelman AC, Lyssiotis CA, Boothman DA. Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone. Cancer & Metabolism. 3: 12. PMID 26462257 DOI: 10.1186/s40170-015-0137-1  1
2015 Hirschey MD, DeBerardinis RJ, Diehl AM, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, et al. Dysregulated metabolism contributes to oncogenesis. Seminars in Cancer Biology. PMID 26454069 DOI: 10.1016/j.semcancer.2015.10.002  1
2015 Sadanandam A, Wullschleger S, Lyssiotis CA, Grotzinger C, Barbi S, Bersani S, Korner J, Wafy I, Mafficini A, Lawlor RT, Simbolo M, Asara JM, Blaker H, Cantley LC, Wiedenmann B, et al. A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics. Cancer Discovery. PMID 26446169 DOI: 10.1158/2159-8290.CD-15-0068  1
2015 Breitkopf SB, Yuan M, Helenius KP, Lyssiotis CA, Asara JM. Triomics Analysis of Imatinib-Treated Myeloma Cells Connects Kinase Inhibition to RNA Processing and Decreased Lipid Biosynthesis. Analytical Chemistry. 87: 10995-1006. PMID 26434776 DOI: 10.1021/acs.analchem.5b03040  1
2014 Lyssiotis CA, Cantley LC. Acetate fuels the cancer engine. Cell. 159: 1492-4. PMID 25525870 DOI: 10.1016/j.cell.2014.12.009  1
2014 Glick GD, Rossignol R, Lyssiotis CA, Wahl D, Lesch C, Sanchez B, Liu X, Hao LY, Taylor C, Hurd A, Ferrara JL, Tkachev V, Byersdorfer CA, Boros L, Opipari AW. Anaplerotic metabolism of alloreactive T cells provides a metabolic approach to treat graft-versus-host disease. The Journal of Pharmacology and Experimental Therapeutics. 351: 298-307. PMID 25125579 DOI: 10.1124/jpet.114.218099  1
2014 Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sánchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, et al. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature. 514: 628-32. PMID 25119024 DOI: 10.1038/nature13611  1
2014 Lyssiotis CA, Cantley LC. Targeting metabolic scavenging in pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 6-8. PMID 24166909 DOI: 10.1158/1078-0432.CCR-13-2570  1
2013 Lyssiotis CA, Cantley LC. Metabolic syndrome: F stands for fructose and fat. Nature. 502: 181-2. PMID 24108049 DOI: 10.1038/502181a  1
2013 Deshmukh VA, Tardif V, Lyssiotis CA, Green CC, Kerman B, Kim HJ, Padmanabhan K, Swoboda JG, Ahmad I, Kondo T, Gage FH, Theofilopoulos AN, Lawson BR, Schultz PG, Lairson LL. A regenerative approach to the treatment of multiple sclerosis. Nature. 502: 327-32. PMID 24107995 DOI: 10.1038/nature12647  1
2013 Yeo H, Lyssiotis CA, Zhang Y, Ying H, Asara JM, Cantley LC, Paik JH. FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells. The Embo Journal. 32: 2589-602. PMID 24013118 DOI: 10.1038/emboj.2013.186  1
2013 Lyssiotis CA, Son J, Cantley LC, Kimmelman AC. Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance. Cell Cycle (Georgetown, Tex.). 12: 1987-8. PMID 23759579 DOI: 10.4161/cc.25307  1
2013 Bettaieb A, Bakke J, Nagata N, Matsuo K, Xi Y, Liu S, AbouBechara D, Melhem R, Stanhope K, Cummings B, Graham J, Bremer A, Zhang S, Lyssiotis CA, Zhang ZY, et al. Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation. The Journal of Biological Chemistry. 288: 17360-71. PMID 23640882 DOI: 10.1074/jbc.M112.441469  1
2013 Sadanandam A, Lyssiotis CA, Homicsko K, Collisson EA, Gibb WJ, Wullschleger S, Ostos LC, Lannon WA, Grotzinger C, Del Rio M, Lhermitte B, Olshen AB, Wiedenmann B, Cantley LC, Gray JW, et al. A colorectal cancer classification system that associates cellular phenotype and responses to therapy. Nature Medicine. 19: 619-25. PMID 23584089 DOI: 10.1038/nm.3175  1
2013 Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, et al. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature. 496: 101-5. PMID 23535601 DOI: 10.1038/nature12040  1
2013 Lairson LL, Lyssiotis CA, Zhu S, Schultz PG. Small molecule-based approaches to adult stem cell therapies. Annual Review of Pharmacology and Toxicology. 53: 107-25. PMID 23294307 DOI: 10.1146/annurev-pharmtox-011112-140300  1
2013 Shyh-Chang N, Locasale JW, Lyssiotis CA, Zheng Y, Teo RY, Ratanasirintrawoot S, Zhang J, Onder T, Unternaehrer JJ, Zhu H, Asara JM, Daley GQ, Cantley LC. Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science (New York, N.Y.). 339: 222-6. PMID 23118012 DOI: 10.1126/science.1226603  1
2012 Lyssiotis CA, Cantley LC. SIRT6 puts cancer metabolism in the driver's seat. Cell. 151: 1155-6. PMID 23217699 DOI: 10.1016/j.cell.2012.11.020  1
2012 Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis CA, Aldape K, Cantley LC, Lu Z. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature Cell Biology. 14: 1295-304. PMID 23178880 DOI: 10.1038/ncb2629  1
2012 Juvekar A, Burga LN, Hu H, Lunsford EP, Ibrahim YH, Balmañà J, Rajendran A, Papa A, Spencer K, Lyssiotis CA, Nardella C, Pandolfi PP, Baselga J, Scully R, Asara JM, et al. Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer. Cancer Discovery. 2: 1048-63. PMID 22915751 DOI: 10.1158/2159-8290.CD-11-0336  1
2012 Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, et al. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell. 149: 656-70. PMID 22541435 DOI: 10.1016/j.cell.2012.01.058  1
2011 Gao D, Inuzuka H, Tan MK, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S, Lyssiotis CA, Gygi SP, Toker A, Cantley LC, Asara JM, et al. mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Molecular Cell. 44: 290-303. PMID 22017875 DOI: 10.1016/j.molcel.2011.08.030  1
2011 Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nature Genetics. 43: 869-74. PMID 21804546 DOI: 10.1038/ng.890  1
2011 Sadanandam A, Futakuchi M, Lyssiotis CA, Gibb WJ, Singh RK. A cross-species analysis of a mouse model of breast cancer-specific osteolysis and human bone metastases using gene expression profiling. Bmc Cancer. 11: 304. PMID 21774828 DOI: 10.1186/1471-2407-11-304  1
2011 Staerk J, Lyssiotis CA, Medeiro LA, Bollong M, Foreman RK, Zhu S, Garcia M, Gao Q, Bouchez LC, Lairson LL, Charette BD, Supekova L, Janes J, Brinker A, Cho CY, et al. Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells. Angewandte Chemie (International Ed. in English). 50: 5734-6. PMID 21547985 DOI: 10.1002/anie.201101042  1
2011 Lyssiotis CA, Lairson LL, Boitano AE, Wurdak H, Zhu S, Schultz PG. Chemical control of stem cell fate and developmental potential. Angewandte Chemie (International Ed. in English). 50: 200-42. PMID 21184400 DOI: 10.1002/anie.201004284  1
2009 Zhu S, Wurdak H, Wang Y, Galkin A, Tao H, Li J, Lyssiotis CA, Yan F, Tu BP, Miraglia L, Walker J, Sun F, Orth A, Schultz PG, Wu X. A genomic screen identifies TYRO3 as a MITF regulator in melanoma. Proceedings of the National Academy of Sciences of the United States of America. 106: 17025-30. PMID 19805117 DOI: 10.1073/pnas.0909292106  1
2009 Blatt NB, Boitano AE, Lyssiotis CA, Opipari AW, Glick GD. Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax. Biochemical Pharmacology. 78: 966-73. PMID 19481066 DOI: 10.1016/j.bcp.2009.05.025  1
2009 Lyssiotis CA, Foreman RK, Staerk J, Garcia M, Mathur D, Markoulaki S, Hanna J, Lairson LL, Charette BD, Bouchez LC, Bollong M, Kunick C, Brinker A, Cho CY, Schultz PG, et al. Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proceedings of the National Academy of Sciences of the United States of America. 106: 8912-7. PMID 19447925 DOI: 10.1073/pnas.0903860106  1
2009 Zhu S, Wurdak H, Wang J, Lyssiotis CA, Peters EC, Cho CY, Wu X, Schultz PG. A small molecule primes embryonic stem cells for differentiation. Cell Stem Cell. 4: 416-26. PMID 19427291 DOI: 10.1016/j.stem.2009.04.001  1
2008 Blatt NB, Boitano AE, Lyssiotis CA, Opipari AW, Glick GD. Bz-423 superoxide signals apoptosis via selective activation of JNK, Bak, and Bax. Free Radical Biology & Medicine. 45: 1232-42. PMID 18718527 DOI: 10.1016/j.freeradbiomed.2008.07.022  1
2007 Lyssiotis CA, Walker J, Wu C, Kondo T, Schultz PG, Wu X. Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells Proceedings of the National Academy of Sciences of the United States of America. 104: 14982-14987. PMID 17855562 DOI: 10.1073/pnas.0707044104  1
2004 Bednarski JJ, Lyssiotis CA, Roush R, Boitano AE, Glick GD, Opipari AW. A novel benzodiazepine increases the sensitivity of B cells to receptor stimulation with synergistic effects on calcium signaling and apoptosis. The Journal of Biological Chemistry. 279: 29615-21. PMID 15123639 DOI: 10.1074/jbc.M403507200  1
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